1,3,5-triazine Ring Patents (Class 544/113)
  • Publication number: 20040077515
    Abstract: The present invention relates to novel compounds represented by the formula (1): wherein R1 and R2, independently, represent —NH2, NH(C1-C4alkyl), —N(C1-C4alkyl)2, —NH(C2-C4hydroxyalkyl), —N(C2-C4hydroxyalkyl)2, —N(C1-C4alkyl)(C2-C4hydroxyalkyl), —NH(C1-C4alkoxy-C2-C4hydroxyalkyl), —N(C1-C4alkoxy-C2-C4hydroxyalkyl)2, —N(C1-C4alkoxy-C2-C4hydroxyalkyl)(C1-C4alkyl), —N(C1-C4alkkoxy-C2-C4hydroxyalkyl)(C2-C4hydroxyalkyl), NH(C1-C4alkoxy-C1-C4-alkoxy-C1-C4alkyl), —N(C1-C4alkoxy-C1-C4alkkoxy-C1-C4-alkyl)2, —N(C1-C4alkoxy-C1-C4alkoxy-C1-C4-alkyl)(C1-C4alkyl), —N(C1-C4alkoxy-C1-C4alkoxy-C2-C4-alkyl)(C2-C4hydroxyalkyl) —NH(C5-C7cycloalkyl), —N(C5-C7cycloakyl)2, —NH(C6-C10aryl), NH(C7-C13-aralkyl) or a morpholino, piperidino or pyrrolidino residue; halogen or —OC1-C4alkyl, which is unsubstituted or substituted by hydroxy or —C1-C4alkoxy, a process for their preparation and their use as fluorescent whitening agents (FWA'
    Type: Application
    Filed: August 18, 2003
    Publication date: April 22, 2004
    Inventors: Georges Metzger, Serge Hauger, Fabienne Cuesta
  • Patent number: 6673922
    Abstract: A high yield process for preparing 4,6-dialkoxy-1,3,5-triazine-2-halide by reacting a cyanuric halide with an alcohol compound such as methanol in the presence of an alkali such as sodium hydrogencarbonate, wherein the water content present in the reaction system at the beginning of the reaction is controlled to not more than 0.5 mol based on 1 mol of the cyanuric halide or the water content present in the reaction system during the period of the reaction is controlled to not more than 2.5 mol based on 1 mol of the cyanuric halide.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: January 6, 2004
    Assignee: Tokuyama Corporation
    Inventors: Masako Saijo, Naoki Hirano
  • Publication number: 20040002424
    Abstract: The compounds of the formula (I) and salts thereof 1
    Type: Application
    Filed: February 18, 2003
    Publication date: January 1, 2004
    Inventors: Klemens Minn, Hartmut Ahrens, Hansjorg Dietrich, Lothar Willms, Thomas Auler, Hermann Bieringer, Hubert Menne
  • Publication number: 20040002496
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: March 14, 2003
    Publication date: January 1, 2004
    Inventors: David Bebbington, Hayley Binch, Jean-Damien Charrier, Simon Everitt, Julian M. C. Golec, David Kay, Ronald Knegtel, Andrew Miller, Francoise Pierard
  • Publication number: 20030225073
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: March 14, 2003
    Publication date: December 4, 2003
    Inventors: David Bebbington, Hayley Binch, Jean-Damien Charrier, Simon Everitt, Julian M.C. Golec, David Kay, Ronald Knegtel, Andrew Miller, Francoise Pierard, Albert C. Pierce
  • Patent number: 6645916
    Abstract: This invention provides for 2,4-diamino-1,3,5-triazines, their preparation and their use as herbicides or plant growth regulators.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: November 11, 2003
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Jürgen Zindel, Jens Hollander, Klemens Minn, Lothar Willms, Hermann Bieringer, Christopher Rosinger
  • Publication number: 20030203820
    Abstract: This invention provides for 2,4-diamino-1,3,5-triazines, their preparation and their use as herbicides or plant growth regulators.
    Type: Application
    Filed: January 24, 2003
    Publication date: October 30, 2003
    Inventors: Jurgen Zindel, Jens Hollander, Klemens Minn, Lothar Willms, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6638926
    Abstract: This invention provides novel pyrazole compounds that are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3. The compounds may be used to treat abnormal physiological function leading to diseases such as cancer, diabetes and Alzheimer's disease.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: October 28, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Robert J. Davies, Pan Li, Jean-Damien Charrier, David Bebbington
  • Publication number: 20030195210
    Abstract: The invention relates to novel imidazo[1,3,5]triazinones of the general formula (I), to a method for their production and to their use as medicaments, in particular as inhibitors of cyclic GMP metabolising phosphodiesterases.
    Type: Application
    Filed: November 4, 2002
    Publication date: October 16, 2003
    Inventors: Ulrich Niewhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Publication number: 20030191125
    Abstract: The present invention provides novel compounds, and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsey, irritable bowl syndrome, immune supression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems.
    Type: Application
    Filed: March 17, 2003
    Publication date: October 9, 2003
    Inventors: Robert John Chorvat, Parthasarathi Rajagopalan
  • Patent number: 6624160
    Abstract: This invention provides compounds of formula I; which are useful as antiviral agents.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: September 23, 2003
    Assignee: Pharmacia & Upjohn Co.
    Inventors: Valerie A. Vaillancourt, Scott D. Larsen, Sajiv K. Nair
  • Publication number: 20030171374
    Abstract: This invention concerns HIV replication inhibitors of formula 1
    Type: Application
    Filed: November 8, 2002
    Publication date: September 11, 2003
    Inventors: Michael Joseph Kukla, Donald William Ludovici, Robert William Kavash, Bart Lieven Daniel De Corte, Jan Heeres, Paul Adriaan Jan Janssen, Lucien Maria Henricus Koymans, Marc Rene de Jonge, Koen Jeanne Alfons Van Aken, Alain Krief, Ruben Gerardus George Leenders
  • Patent number: 6610677
    Abstract: This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula VIII: wherein Z1 is N or C—R9, Z2 is N or CH, and Z3 is N or C—Rx, provided that one of Z1 and Z3 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and Rx, R1, R2, R2′, R3, and R9 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: August 26, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Robert Davies, Pan Li, Julian M. C. Golec, Jean-Damien Charrier, Ronald Knegtel, David Bebbington
  • Publication number: 20030109530
    Abstract: The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in claim 1. Said compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome.
    Type: Application
    Filed: July 15, 2002
    Publication date: June 12, 2003
    Inventors: Gerard Moinet, Daniel Cravo, Liliane Doare, Micheline Kergoat, Didier Mesangeau
  • Publication number: 20030100557
    Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-&bgr; activity.
    Type: Application
    Filed: September 6, 2002
    Publication date: May 29, 2003
    Applicant: Cell Therapeutics, Inc.
    Inventors: Robert Finney, David Leung, J. Peter Klein, David M. Hollenback, Lynn Bonham, Scott A. Shaffer, Norina M. Tang, Thayer H. White, John Tulinsky, Baoqing Gong
  • Publication number: 20030096991
    Abstract: The invention relates to the preparation of compounds (I) 1
    Type: Application
    Filed: November 5, 2002
    Publication date: May 22, 2003
    Inventors: Gerhard Schnabel, Jan Vermehren, Lothar Willms
  • Publication number: 20030045444
    Abstract: Biphenyl-substituted triazines of the formulae 1
    Type: Application
    Filed: July 31, 2002
    Publication date: March 6, 2003
    Inventors: Ian John Fletcher, Jurgen Kaschig, Georges Metzger, Dieter Reinehr, Pascal Hayoz
  • Patent number: 6509338
    Abstract: The present invention describes novel pyrazolo[1,5-a]triazines of formula: wherein R3 is an alkyl, alkenyl, alkynyl, or cycloalkyl group, or pharmaceutically acceptable salt forms thereof, which are useful as CRF antagonists.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: January 21, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Richard Eric Olson, William Eric Frietze
  • Publication number: 20030013879
    Abstract: This invention relates to a novel, efficient, economic and general-purpose process for isolating monophenolic-bisaryl triazine compounds from polyphenolic-triazines compounds and other impurities. More specifically, this invention relates to a process for isolating the monophenolic-bisaryl triazine compounds by contacting it with a base, an alcohol or a hydrocarbon solvent.
    Type: Application
    Filed: June 22, 2001
    Publication date: January 16, 2003
    Inventors: Ram Baboo Gupta, Hargurpreet Singh, Russell C. Cappadona
  • Publication number: 20020147181
    Abstract: This invention concerns the compounds of formula 1
    Type: Application
    Filed: November 15, 2001
    Publication date: October 10, 2002
    Inventors: Paul A.J. Janssen, Jan Heeres, Henri E.L. Moereels, Michael Joseph Kukla, Donald W. Ludovici
  • Patent number: 6458950
    Abstract: A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R1 is hydrogen, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; A is an optionally substituted lower alkylene, an optionally substituted lower alkenylene or a single bond; B is an optionally substituted imino or a single bond; or A and B taken together may form a single bond; and D is a single bond or a group of the formula (a):
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 1, 2002
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yasuhiro Nishitani, Koji Ishikura
  • Patent number: 6458788
    Abstract: Certain novel 4-hydroxycinnoline-3-carboxyamides. The compounds are particularly effective in the treatment or prevention of viral infections, particularly infections caused by herpes viruses including herpes simplex virus types 1 and 2, human herpes virus types 6, 7 and 8, varicello zoster virus, human cytomegalovirus or Epstein-Barr virus.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: October 1, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Valerie A. Vaillancourt, Scott D. Larsen, Sajiv K. Nair
  • Publication number: 20020103195
    Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-&bgr; activity.
    Type: Application
    Filed: October 31, 2001
    Publication date: August 1, 2002
    Applicant: CELL THERAPEUTICS,INC.
    Inventors: Lynn Bonham, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung
  • Publication number: 20020082259
    Abstract: This invention relates to triazine compounds of formula (I): 1
    Type: Application
    Filed: November 30, 2001
    Publication date: June 27, 2002
    Inventors: M Ono, Lijun Sun, Shijie Zhang, Teresa Przewloka, David A. James, Wenli Ding, Yumiko Wada
  • Publication number: 20020049207
    Abstract: CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke.
    Type: Application
    Filed: November 27, 2001
    Publication date: April 25, 2002
    Inventor: James R. McCarthy
  • Patent number: 6365737
    Abstract: A process for the preparation of a 4,4′-bis-(triazinylamino)-stilbene-2,2′-disulphonic acid compound of formula (1) is disclosed, characterized in that (a) in a first reaction step cyanurchloride is reacted with the disodium salt of 4,4′-diaminostilbene-2,2′-disulfonic acid to give the intermediate of formula (2); (b) in a second reaction step the compound of formula (2) is reacted with a compound of formula R1—H and/or R2—H to give the compound of formula (3); (c) in a third step the compound of formula (3) is reacted with the compound of the formula R3H, and reaction step (a) and/or (c) are carried out in a medium consisting of a mixture of water and a polyglycol to give the compound of formula (1), wherein R1, R2 and R3, independently, are phenylamino; phenylamino substitued by C1-C3alkyl, halogen, cyano, COOR or COR; CONH—R; SO2NH—R; NH—COR; mono- or disulphonated phenylamino; morpholino; piperidino; pyrrolidino; —NH2; —NH
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: April 2, 2002
    Assignee: Ciba Specialty Chemical Corporation
    Inventors: Georges Metzger, Fabienne Cuesta, Peter Rohringer, Dieter Reinehr, René Schlatter
  • Patent number: 6352987
    Abstract: 8,8a-Dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments The invention relates to polycyclic dihydrothiazoles and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of formula I, in which the radicals are as defined above, and their physiologically acceptable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: March 5, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Jaehne, Hans Jochen Lang, Matthias Gossel, Martin Bickel
  • Patent number: 6335450
    Abstract: This invention provides cyclic-bridged dyes, particularly cyclic-bridged cyanine dyes, of the general formula: In this formula, each dotted line represents carbon atoms necessary to form a fused substituted or unsubstituted aromatic ring; n=1-18; m=1-18, selected independently from n. X and Y are selected independently from the group consisting of S, O, N, CH2 and C(CH3)2; at least one of said R1 and R2 comprises a sulfonic acid or sulfonate group attached to the aromatic ring; and R3 and R4 are independently selected from the group consisting of carboxyl, activated carboxyl and methyl, wherein at least one of said R3 and R4 groups is carboxylate or activated carboxylate. Methods of making and using the cyclic-bridged dyes are also provided.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: January 1, 2002
    Assignee: Beckman Coulter, Inc.
    Inventors: Firdous Farooqui, Maged A. Michael, M. Parameswara Reddy
  • Patent number: 6331632
    Abstract: This invention provides dye phosphoramidites, particularly phosphoramidites of cyanine and related dyes, of the general formula: In this formula, each dotted line represents carbon atoms necessary to form a fused substituted or unsubstituted aromatic ring; m is an integer from 1 to 18; Y and Z are independently selected from the group consisting of S, O, N, CH2 and C(CH3)2; R1 is an alkyl; (PAM) is a phosphoramidite group; X⊖ is a negative ion; and Q is or wherein n is 1, 2 or 3. Methods of making and using the dye phosphoramidites are also provided.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: December 18, 2001
    Assignee: Beckman Coulter, Inc.
    Inventors: M. Parameswara Reedy, Firdous Farooqui, Maged A. Michael
  • Patent number: 6326368
    Abstract: The present invention provides novel compounds, and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsey, irritable bowl syndrome, immune supression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R5, Q, Z, Y, V, X and X′ are as defined herein.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: December 4, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Robert John Chorvat, Parthasarathi Rajagopalan
  • Patent number: 6313124
    Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: November 6, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Liqi He, Paul Gilligan, Robert Chorvat, Argyrios Georgios Arvanitis
  • Patent number: 6265348
    Abstract: Compounds of the formula (I) and salts thereof in which R1 to R6, W, X, Y and Z are defined as in claim 1, have herbicidal or plant growth-regulatory properties. They can be prepared by processes analogous to known processes (cf. claim 5), in some cases via novel intermediate products (cf.
    Type: Grant
    Filed: February 17, 1999
    Date of Patent: July 24, 2001
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Heinz Kehne, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6235738
    Abstract: The invention relates to novel diphenyl-substituted heterocycles with 6-membered ring of general formula (I) in which A, X and the residues R1, R2, R3, R4 and R5 are as defined in the claims, processes for the preparation thereof and the use thereof as medicaments.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: May 22, 2001
    Assignees: Boehringer Ingelheim Pharma KG, Boehringer Ingelheim Italia S.p.A.
    Inventors: Michael Brenner, Rainer Palluk, Marion Wienrich, Thomas Weiser, Enzo Cereda, Maura Bignotti, Carlo Maria Pellegrini, Giovanni Battista Schiavi, Raffaele Cesana
  • Patent number: 6225050
    Abstract: Cyanine and related dyes, such as merocyanine, styryl and oxonol dyes, are strongly light-absorbing and highly luminescent. Cyanine and related dyes having functional groups make them reactive with amine, hydroxy and sulfhydryl groups are covalently attached to proteins, nucleic acids, carbohydrates, sugars, cells and combinations thereof, and other biological and nonbiological materials, to make these materials fluorescent so that they can be detected. The labeled materials can then be used in assays employing excitation light sources and luminescence detectors. For example, fluorescent cyanine and related dyes can be attached to amine, hydroxy or sulfhydryl groups of avidin and to antibodies and to lectins. Thereupon, avidin labeled with cyanine type dyes can be used to quantify biotinvlated materials and antibodies conjugated with cyanine-type dyes can be used to detect and measure antigens and haptens. In addition, cyanine-conjugated lectins can be used to detect specific carbohydrate groups.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: May 1, 2001
    Assignee: Carnegie Mellon University
    Inventor: Alan S. Waggoner
  • Patent number: 6194413
    Abstract: The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: February 27, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Pradip Kumar Bhatnagar, Dirk Andries Heerding
  • Patent number: 6190923
    Abstract: The present invention relates to the field of immunoassays for metal ions. The invention presents: chelators, chelates, antibodies specific for the chelates, tracers comprising chelates conjugated to detectable labels, and immunoassays utilizing the foregoing.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: February 20, 2001
    Inventor: David K. Johnson
  • Patent number: 6191131
    Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: February 20, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Liqi He, Paul Gilligan, Robert Chorvat, Argyrios Georgios Arvanitis
  • Patent number: 6177491
    Abstract: Compounds of formula (I), wherein n is a number from 2 to 14; R1 is for example C1-C18alkyl or C5-C12cycloalkyl; R2 is for example C2-C12alkylene; A is for example acetyl, (C1-C4alkoxy)carbonyl, (C1-C4alkyl)aminocarbonyl or C1-C4alkyl; B is —OR3, —N(R4(R5) or a group of formula (II); R3, R4 and R5, which are identical or different, are for example hydrogen or C1-C18alkyl, or —N(R4)(R5) is additionally a group of formula (III) with Y being —O—, —CH2—, —CH2CH2— or >N—CH3; X is —O— or >N—R6; R6 is for example hydrogen or C1-C18alkyl; and R is preferably a group of formula (IV); with the proviso that in the individual recurrent units of formula (I), each of the radicals B, R, R1 and R2 has the same or a different meaning. The indicated compounds are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: January 23, 2001
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: James Peter Galbo, Dario Lazzari, Fabrizio Guizzardi
  • Patent number: 6174940
    Abstract: The present invention relates to mixtures comprising the compound I in a proportion of 65-95% by weight, the compound II in a proportion of 5-35% by weight and the compound III in a proportion of 0-10% by weight wherein the substituents are as defined in the description, and to mixtures with other compounds. The mixtures are suitable for stabilizing organic material against the effect of light and heat.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: January 16, 2001
    Assignee: Clariant GmbH
    Inventors: Thomas St{umlaut over (a)}hrfeldt, Mathias Mehrer, Matthias Z{umlaut over (a)}h, Gerhard Pfahler
  • Patent number: 6150360
    Abstract: This invention concerns the use of the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR.sup.4 or N; n is 0, 1, 2, 3 or 4; R.sup.1 and R.sup.2 are each independently selected from hydrogen, hydroxy, C.sub.1-12 alkyl, C.sub.1-12 alkyloxy, C.sub.1-12 alkylcarbonyl, C.sub.1-12 -alkyloxycarbonyl, aryl, amino, mono- or di(C.sub.1-12 alkyl)amino, mono- or di(C.sub.1-12 alkyl)aminocarbonyl wherein each of the aforementioned C.sub.1-12 alkyl groups may optionally and each individually be substituted; or R.sup.1 and R.sup.2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C.sub.1-12 alkyl)aminoC.sub.1-4 alkylidene; R.sup.3 is hydrogen, aryl, C.sub.1-6 alkylcarbonyl, optionally substituted C.sub.1-6 alkyl; and each R.sup.4 independently is hydroxy, halo, C.sub.1-6 alkyl, C.sub.1-6 -alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is --X--R.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: November 21, 2000
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frederik Frans Desire Daeyaert, Bart De Corte, Marc Rene De Jonge, Jan Heeres, Chih Yung Ho, Paul Adriaan Jan Janssen, Robert W. Kavash, Lucien Maria Henricus Koymans, Michael Joseph Kukla, Donald William Ludovici
  • Patent number: 6080208
    Abstract: The present invention provides new stilbene compounds which are useful as fluorescent whitening agents (FWAs), imparting high whiteness levels to textile fibre material treated with them, and which also impart a high sun protection factor (SPF) to textile fibre material treated with them. The present invention also concerns a method of imparting a high whiteness level and a high sun protection factor to textile fibre material, especially cotton, polyamide and wool, comprising treating the textile material with the new compounds.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: June 27, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Dieter Reinehr, Georges Metzger, Hanspeter Sauter
  • Patent number: 6071860
    Abstract: Compounds of the formula (I) and salts thereof ##STR1## where R.sup.1 to R.sup.5, A, Z, X, X', n and m are as defined in claim 1 are suitable as herbicides and plant growth regulators.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: June 6, 2000
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Wolfgang Giencke, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6069114
    Abstract: Compounds of the formula (I) and their salts ##STR1## in which R.sup.1 to R.sup.6, Y.sup.1, to Y.sup.2, Y.sup.3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepared analogously to known processes using intermediates of the formula (V) (cf. claim 6).
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: May 30, 2000
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Klaus Lorenz, Klemens Minn, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6036767
    Abstract: The present invention provides an aqueous pigment dispersion composition for electro-deposition color coating of an aluminum or aluminum alloy oxide film, the composition comprising an organic white pigment as an essential component thereof. The organic white pigment comprises large-diameter particles which are insoluble in a water-soluble organic liquid and/or water and exhibit a non-skinning property and a sufficient concealing power on an aluminum or aluminum alloy oxide film. More specifically, the organic white pigment particles preferably have an average particle diameters of at least 0.3 .mu.m and a reflective index of at least 1.4. The use of the aqueous pigment dispersion composition for electro-deposition coating ensures formation of a less lustrous, less transparent and highly weather-resistant coating film for coloration of an aluminum or aluminum alloy oxide film.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: March 14, 2000
    Assignee: Sakura Color Products Corporation
    Inventors: Shigeyasu Inoue, Tadaaki Ito
  • Patent number: 5925597
    Abstract: Compounds of the formula (I) and their salts as defined in claim 1, ##STR1## in which R.sup.1 is CO--Q--R.sup.8, where R.sup.8 =H or RR.sup.2 and R.sup.3 are H or (C.sub.1 -C.sub.4)alkyl,R.sup.4 is H, R, RO, OH, RCO, RSO.sub.2, PhSO.sub.2R.sup.5 is RSO.sub.2, PhSO.sub.2, PhCO, RNHSO.sub.2, R.sub.2 NSO.sub.2, RCO, CHO, COCOR', CW--T--R.sup.9, CW--NR.sup.10 R.sup.11, CW--N(R.sup.12).sub.2 orR.sup.4 and R.sup.5 together are the chain (CH.sub.2).sub.m B or --B.sup.1 --(CH.sub.2).sub.m1 B-- where B=SO.sub.2, CO; m=3, 4; m.sup.1 =2, 3;T and W=O, S; Q=O, S, NR.sup.13 where R.sup.13 =H, R;R.sup.6 =H, R, RO, RCO, ROCO, Hal, NO.sub.2, CN;R.sup.7 =H, CH.sub.3 ; R.sup.9 =R; R.sup.10, R.sup.11 =H, R; N(R.sup.12).sub.2 =heterocycleA=pyrimidinyl and triazinyl radical or an analog thereof,where R=(substituted) aliphatic hydrocarbon radical, are suitable as selective herbicides. They are prepared by analogous processes via sulfonamides, some of which are new, of the formula (II).
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: July 20, 1999
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Klaus Lorenz, Lothar Willms, Klaus Bauer, Hermann Bieringer
  • Patent number: 5922648
    Abstract: Compounds of the formula (I) and salts thereof ##STR1## in which R.sup.1 to R.sup.9, X, Y n and m are as defined in the claim 1 are suitable as herbicides and plant growth regulators.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: July 13, 1999
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Klaus Lorenz, Klemens Minn, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 5892031
    Abstract: The present invention provides new stilbene compounds which are useful as fluorescent whitening agents (FWAs), imparting high whiteness levels to textile fibre material treated with them, and which also impart a high sun protection factor (SPF) to textile fibre material treated with them. The present invention also concerns a method of imparting a high whiteness level and a high sun protection factor to textile fibre material, especially cotton, polyamide and wool, comprising treating the textile material with the new compounds.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: April 6, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Dieter Reinehr, Georges Metzger, Hanspeter Sauter
  • Patent number: 5837869
    Abstract: An asymmetric dioxazine compound represented, when shown in free acid form, by the general formula (I): ##STR1## wherein T.sub.1 and T.sub.2 represent a hydrogen atom, a chlorine atom, a bromine atom, a lower alkyl group, a phenoxy group or others, A.sub.1 represents an alkyl group, a chlorine atom, a carboxyl group or others, A.sub.2 represents a hydrogen atom, an alkyl group, a chlorine atom, a carboxyl group or others, R represents a hydrogen atom or a lower alkyl group, X and Y represent a halogen atom, a fiber-reactive group or others, respectively, with the proviso that at least one of X and Y is a fiber-reactive group is provided.The compound is suitable for dyeing or printing of a fiber material or the like which has a hydroxy group and/or an amide group, and provides a blue-dyed product with various fastness, including particularly chlorine fastness.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: November 17, 1998
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masato Inoue, Junya Hada, Toshiyuki Araki
  • Patent number: 5776858
    Abstract: 1-Azinyl-tetraozolinones of the following formulae (I) and (II): ##STR1## wherein R.sup.1 and R.sup.2 are independently represent alkyl, haloalkyl, cycloalkyl, alkenyl, haloalkenyl, alkynyl or optionally substituted phenyl, orR.sup.1 and R.sup.2, together with the nitrogen atom to which they are bonded, may form a 5- or 6-membered heterocyclic ring which may optionally contain a further heteroatom, and said heterocyclic ring may optionally be benzo-condensed and/or be substituted by one or more of C.sub.1-4 alkyl(s), andR.sup.3 is a 6-membered heterocyclic aromatic group consisting of carbon atoms and 2 or 3 nitrogen atoms, which may optionally be substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, di(C.sub.1-4 alkyl)amino or phenyl.The compounds of the formula (I) exhibit an excellent herbicidal activity and the compounds of the formula (II) are useful as starting materials in the production of the compounds of the formula (I).
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: July 7, 1998
    Assignee: Nihon Bayer Agrochem K.K.
    Inventors: Toshio Goto, Seishi Ito, Natsuko Minegishi, Tatsuya Yamaoka, Chieko Ueno, Koichi Moriya, Fritz Maurer, Ryo Watanabe
  • Patent number: 5777113
    Abstract: The invention relates to novel compounds of formula I ##STR1## wherein the general symbols are as defined in claim 1, as stabilizers for organic materials against oxidative, thermal or light-induced degradation.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: July 7, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Rita Pitteloud