1,3,5-triazine Ring Patents (Class 544/113)
  • Patent number: 4838929
    Abstract: Sulfonamides such as N-[(4,6-dimethoxypyrimidin-2-aminocarbonyl]-1,3-dihydro-6-methyl-3-oxofuro [3,4-c]pyridine-4-sulfonamide are useful as herbicides and plant growth regulants.
    Type: Grant
    Filed: September 14, 1987
    Date of Patent: June 13, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Mary A. Hanagan
  • Patent number: 4837322
    Abstract: Mixtures of sulfurous triazine compounds and methods of preparing these compounds with the general formula ##STR1## in which R.sup.1, R.sup.2 =H,R.sup.2 =benzyl,R.sup.2, R.sup.3, R.sup.4 =C.sub.1 -C.sub.8 -alkyl, allyl, C.sub.3 -C.sub.8 cycloalkyl, the latter unsubstituted or substituted with 1-3 methyl groups, 2-hydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl orR.sup.3 and R.sup.4 (together): C.sub.4 -C.sub.6 -alkylene, --(CH.sub.2 --CHX).sub.2 Y withX=H, CH.sub.3, Y=O,S,S.sub.a : Polysulfide chain with 2-10 S atoms (i.e. 2.ltoreq.a.ltoreq.10), in which the individual polysulfides are present in such concentrations that the statistical average value of "a" is a whole or fractional numerical value in the range from 2 to 5., characterized in that a triazine compound of the general formula ##STR2## in which R.sup.1, R.sup.2, R.sup.3, R.sup.
    Type: Grant
    Filed: August 27, 1987
    Date of Patent: June 6, 1989
    Assignee: Degussa Aktiengesellschaft
    Inventors: Ulrich Deschler, Georg Hellwig, Rudolf Michel, Peter Kleinschmit, Siegfried Wolff
  • Patent number: 4824834
    Abstract: Pyrazolotriazine compounds of the formula: ##STR1## wherein R.sup.1 is OH or alkanoyloxy; R.sup.2 is H, OH, or SH; R.sup.3 is (1) unsaturated N- or S-containing heterocyclic group optionally having 1-2 substituents of halogen, nitro or phenylthio, (2) naphthyl, (3) phenyl optionally having 1-3 substituents of (i) alkyl, (ii) phenyl, (iii) alkoxycarbonyl, (iv) cyano, (v) nitro, (vi) alkoxy, (vii) phenylalkoxy (viii) phenylthio-alkyl, (ix) phenoxy, (x) ##STR2## R is alkyl, halo-substituted alkyl, phenyl optionally having 1-3 substituents, or pyridyl, and l is 0, 1 or 2, (xi) halogen, (xii) phenylalkyl, (xiii) carboxy, (xiv) alkanoyl, (xv) benzoyl optionally having 1-3 substituents, (xvi) amino, (xvii) OH, (xviii) alkanoyloxy, (xix) ##STR3## or (xx) ##STR4## (A is alkylene), said compounds having a xanthine oxidase inhibitory activity and are useful for the prophylaxis and treatment of gout.
    Type: Grant
    Filed: October 8, 1987
    Date of Patent: April 25, 1989
    Assignee: Otsuka Pharmaceutical Company, Limited
    Inventors: Setsuro Fujii, Hiroyuki Kawamura, Hiroshi Kiyokawa, Satoshi Yamada
  • Patent number: 4816507
    Abstract: Compounds of the formula (I) ##STR1## wherein R.sub.1 and R.sub.5 are independently hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl or a group of the formula (II), ##STR2## R.sub.2, R.sub.3 and R.sub.4 are independently C.sub.2 -C.sub.12 -alkylene, R is a group of the formula (III) ##STR3## wherein R.sub.6 is C.sub.2 -C.sub.8 -dialkylamino, C.sub.1 -C.sub.4 -alkoxy, a 5-membered to 7-membered heterocyclic group containing a nitrogen atom which is attached to the triazine residue or a group of the formula (IV), ##STR4## R.sub.7 and R.sub.8 are independently C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, benzyl or a group of the formula (II), subject to the proviso that both, R.sub.1 and R.sub.5 are different from hydrogen, if R is a group ##STR5## are useful as light stabilizers, heat stabilizers and/or oxidation stabilizers for organic materials, in particular synthetic polymers.
    Type: Grant
    Filed: August 14, 1987
    Date of Patent: March 28, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Erfinders G. Cantatore, Francois Gugumus
  • Patent number: 4812161
    Abstract: Thia-diazole derivatives having the following partial structural formula had selective herbicidal activity on some crops.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: March 14, 1989
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Kenji Hagiwara, Hisao Ishikawa, Hideo Hosaka, Hideo Inaba
  • Patent number: 4802910
    Abstract: Novel herbicides of the formula ##STR1## in which R.sup.1 represents an organic radical,R.sup.2 represents hydrogen or an organic radical,R.sup.3 represents an organic radical or an amino radical,R.sup.4 represents hydrogen, an organic radical, an ether radical or an amino radical,X represents N or CH,Y and Z each represent N, CH or a substituted C radical, andM is H, a metal ion or an acyl radical, or a strong acid adduct thereof. Some intermediates are also new.
    Type: Grant
    Filed: January 20, 1987
    Date of Patent: February 7, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Theodor Pfister, Hans-Jochem Riebel, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4788190
    Abstract: Novel 1,3-dioxolane compounds useful as antifungal and antiallergy agents and represented by the formula ##STR1## wherein Ar is thienyl, pyridyl, biphenyl, phenyl or phenyl substituted by one or more of halo, nitro, cyano, lower alkyl, lower alkoxy or perhalo(lower)alkyl; Y is CH or N;Q is ##STR2## W is --NR.sub.5 --, --O--, --S(O).sub.n --; X is NO.sub.2, NR.sub.6 R.sub.7 or COR.sub.8 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl or (C.sub.2 -C.sub.6) alkanoyl; R.sub.6 and R.sub.7 are independently hydrogen, lower alkyl, phenyl or phenyl substituted by one or more of halo, perhalo loweralkyl, (C.sub.2 -C.sub.6)alkanoyl lower alkyl, lower alkoxy or 2-loweralkyl-3-oxo-1,2,4-trirazol-4-yl or R.sub.6 and R.sub.7 taken together with the nitrogen atom in NR.sub.6 R.sub.7 form substituted or unsubstituted heterocyclyl, said heterocyclyl substituents being (C.sub.2 -C.sub.
    Type: Grant
    Filed: December 24, 1986
    Date of Patent: November 29, 1988
    Assignee: Schering Corporation
    Inventors: Anil K. Saksena, Alan B. Cooper, Henry Guzik, Viyoor M. Girijavallabhan, Ashit K. Ganguly
  • Patent number: 4786645
    Abstract: A compound of the general formula I: ##STR1## in which Ar is a pyridyl, quinolinyl, isoquinolinyl, naphthyridinyl, pyrimidyl, quinazolinyl, thiazolyl, benzothiazolyl, imidazolyl, benzimidazolyl, oxazolyl, benzoxazolyl, thienyl, benzothienyl or naphthyl group; optionally substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, alkylcarbonyl, benzoyl, alkyloxycarbonyl, carboxy, phenoxycarbonyl, alkylcabonyloxy, benzoyloxy, alkylcarbonylamino, benzamido, phenyl, benzyl, phenoxy or phenylthio group, provided that (i) when Ar is a pyridyl group, the pyridyl group must be substituted, (ii) an alkyl moiety contains 1 to 4 straight- or branched chain carbon atoms; (iii) a phenyl moiety may be unsubstituted or substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, phenyl or benzyl group
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: November 22, 1988
    Assignee: Rhone-Poulenc Sante
    Inventors: Jean-Louis Fabre, Claude James, Daniel Lave
  • Patent number: 4786315
    Abstract: N-Arylsulfonyl-N'-(4-mercaptomethyl-pyrimidinyl- and -triazinyl)-ureas of the formula: ##STR1## and the salts of these compounds with amines, alkali metal bases or alkaline-earth metal bases or with ammonium bases, have good pre- and post-emergence-selective, herbicidal and growth-regulating properties.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: November 22, 1988
    Assignee: Ciba-Geigy Corporation
    Inventor: Werner Topfl
  • Patent number: 4786316
    Abstract: A class of ortho-sulfamoyl sulfonamides are useful as pre-emergent or post-emergent herbicides and plant growth regulants.
    Type: Grant
    Filed: December 12, 1986
    Date of Patent: November 22, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Chi-Ping Tseng
  • Patent number: 4786311
    Abstract: Tetrazole-substituted benzenesulfonamides are useful as agricultural chemicals and, in particular, as growth regulants and herbicides.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: November 22, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: George Levitt
  • Patent number: 4786313
    Abstract: The invention relates to certain pyridine sulfonamide compounds having haloalkenyl substituents ortho to the sulfonylurea linkage.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: November 22, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: James V. Hay, Barry A. Wexler, Donna F. Zimmerman
  • Patent number: 4764205
    Abstract: This invention relates to herbicidal benzene sulfonamides containing a five or six membered heterocyclic ring consisting of 2-3 heteroatoms and 1-2 carbonyl groups as a substituent on benzene.
    Type: Grant
    Filed: June 19, 1987
    Date of Patent: August 16, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Morris P. Rorer
  • Patent number: 4759790
    Abstract: This invention relates to herbicidally active sulfonamide compounds having a heterocyclic carbonyl group ortho to the sulfonyl bridge.
    Type: Grant
    Filed: May 21, 1987
    Date of Patent: July 26, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Joel R. Christensen
  • Patent number: 4755211
    Abstract: This invention relates to herbicidally active sulfonamide compounds, agriculturally suitable compositions thereof and a method of their use as general and/or selective herbicides or plant growth regulants. More specifically the herbicidally active sulfonamides of this invention have an ortho cyclic saturated or partially saturated group which includes a carbonyl or sulfonyl radical.In the most common situation, the control of undesired vegetation is desired to permit the growth of useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such useful crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides are desired which will control all plant growth. Examples of areas in which complete control of all vegetation is desired and areas around fuel storage tanks, ammunition depots and industrial storage areas.
    Type: Grant
    Filed: January 29, 1987
    Date of Patent: July 5, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Mark E. Thompson
  • Patent number: 4754032
    Abstract: Compounds of formula I ##STR1## can be used as optical brighteners.
    Type: Grant
    Filed: February 26, 1986
    Date of Patent: June 28, 1988
    Assignee: Sandoz Ltd.
    Inventors: David L. Connell, John M. Farrar, Jurg Heller, Hans-Rudolf Schmid
  • Patent number: 4746356
    Abstract: This invention relates to novel sulfonylurea herbicidal compounds, agriculturally suitable compositions thereof and a method-of-use of said compounds and compositions as general preemergence and/or postemergence herbicides or their use as plant growth regulants.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: May 24, 1988
    Assignee: E. I. DuPont De Nemours and Company
    Inventors: David L. Douglass, Marcus P. Moon
  • Patent number: 4743294
    Abstract: A selective herbicide of the formula ##STR1## in which m is 0, 1 or 2,R.sup.5 is an organic radical,R.sup.3 is hydrogen or an organic radical,R.sup.9 is hydrogen or an optionally substituted alkyl radical,R.sup.10 is an organic radical or forms a ring with R.sup.9,R.sup.40 and R.sup.41 are alkyl or alkoxy, andM is hydrogen or a metal or ammonium radical, or an acid adduct thereof.
    Type: Grant
    Filed: April 22, 1987
    Date of Patent: May 10, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Joachim Diehr, Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Theodor Pfister, Uwe Priesnitz, Hans-Jochem Riebel, Wolfgang Roy, Hans-Joachim Santel, Robert R. Schmidt, Koichi Moriya, Ludwig Eue, Klaus Lurssen
  • Patent number: 4743295
    Abstract: Thiocarbonylsulfonylureas, useful as herbicides and plant growth regulants, herbicidal compositions employing these compounds and methods of applying them to soil or directly to plants have been discovered.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: May 10, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Wallace C. Petersen
  • Patent number: 4743688
    Abstract: Poly-2,2,6,6 tetramethyl piperidyl amino spiro glycol ether-1,3,5-triazines are provided having the formula: ##STR1## in which: R is selected from the group consisting of hydrogen, alkyl having from one to about eighteen carbon atoms, hydroxyalkyl having from two to about six carbon atoms; epoxyalkyl having from three to about eight carbon atoms; alkylaryl having from seven to about eighteen carbon atoms; acyl having from two to about eight carbon atoms; and oxyl;each of R.sub.1 and R.sub.2 is selected from the group consisting of hydrogen, alkyl having from one to about eighteen carbon atoms; and alkylene forming a heterocyclic ring including the nitrogen atom in the ring and having from four to seven carbon atoms and no or one oxygen atom; andn is a number from 2 to about 40 representing the average number of units enclosed by the brackets; and synthetic resin compositions containing the same as light stabilizers.
    Type: Grant
    Filed: September 2, 1986
    Date of Patent: May 10, 1988
    Assignee: Adeka Argus Chemical Co., Ltd.
    Inventors: Motonobu Minagawa, Yutaka Nakahara, Toshihiro Shibata, Etsuo Tobita
  • Patent number: 4741765
    Abstract: Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide, agricultural compositions containing them, and their herbicidal utility are disclosed.
    Type: Grant
    Filed: April 3, 1987
    Date of Patent: May 3, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Robert J. Pasteris, Ramaurthi Muthukrishnan
  • Patent number: 4734413
    Abstract: Substituted 1,2,4-triazolo[1,5-a]triazines as bronchodilators are disclosed. Pharmaceutical formulations comprising such compounds and pharmacological methods of using such compounds are also described.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: March 29, 1988
    Assignee: Riker Laboratories, Inc.
    Inventor: James J. Wade
  • Patent number: 4725305
    Abstract: Herbicidally active novel N,N'-bis-sulphonyl guanidines of the formula ##STR1## in which M is hydrogen, a metal or an ammonium radical, andR.sup.4, R.sup.5, R.sup.40 and R.sup.41 are various organic radicals.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: February 16, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Koichi Moriya, Theodor Pfister, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt, Klaus Lurssen, Hans-Joachim Diehr, Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Uwe Priesnitz, Wolfgang Roy, Hans-Joachim Santel
  • Patent number: 4723990
    Abstract: o-Haloalkylbenzene sulfonylureas are useful as herbicides.
    Type: Grant
    Filed: January 23, 1987
    Date of Patent: February 9, 1988
    Assignee: E. I. DuPont De Nemours and Co.
    Inventor: William B. Farnham
  • Patent number: 4723988
    Abstract: Thiophenesulfonamides such as N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-3-(isoxazol-3-yl)-2-thiophen esulfonamide are useful as herbicides and plant growth regulants.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: February 9, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Rafael Shapiro
  • Patent number: 4718938
    Abstract: Ortho-Hydrazinosulfonyl benzenesulfonylureas, such as 2-(2,2-dimethylhydrazinosulfonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocar bonyl]benzenesulfonamide, are useful as pre-emergent and post-emergent herbicides.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: January 12, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Donald J. Dumas
  • Patent number: 4707178
    Abstract: Herbicidally active pyrazolesulfonamide compounds having an ortho cyclic saturated or partially saturated group which includes a carbonyl or sulfonyl radical having utility as herbicides and plant growth regulants.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: November 17, 1987
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Mark E. Thompson
  • Patent number: 4707179
    Abstract: Herbicidally active pyridinesulfonamide compounds having an ortho cyclic saturated or partially saturated group which includes a carbonyl or sulfonyl radical display utility as herbicides and plant growth regulants.
    Type: Grant
    Filed: February 17, 1987
    Date of Patent: November 17, 1987
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Mark E. Thompson
  • Patent number: 4698352
    Abstract: This invention relates to a novel 4-oxo-1,4-dihydronicotinic acid derivative ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen or carboxyl-protecting group;R.sup.2 is substituted phenyl and naphthyl, or a substituted or unsubstituted heterocyclic group; andR.sup.3 is haloalkyl, aminoalkyl, or substituted or unsubstituted alkenyl, phenylalkenyl, naphthylalkenyl, phenylalkyl, naphthylalkyl, phenylalkynyl, naphthylalkynyl, heterocyclic alkyl, heterocyclic alkenyl, phenyl, naphthyl, cycloalkyl, cycloalkenyl, carboxylic acyl, iminoalkyl, heterocyclic or bridged hydrocarbon, which has a broad antibacterial spectrum and a low toxicity, and are useful for treatment of diseases of human beings and animals, to a process for producing the same and to an antibacterial agent containing the same.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: October 6, 1987
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Hirokazu Narita, Yoshinori Konishi, Jun Nitta, Shunjiro Misumi, Hideyoshi Nagaki, Isao Kitayama, Yoriko Nagai, Yasuo Watanabe, Nobuyuki Matsubara, Shinzaburo Minami, Isamu Saikawa
  • Patent number: 4695632
    Abstract: Quaternary compounds of the formula ##STR1## wherein K.sym. denotes a cationic organic radical,X denotes a linking member,R denotes the radical of a heterocyclic reactive group,m denotes the numbers 1 or 2,n denotes the numbers 1 or 2 andAn.crclbar. denotes an anion,can be used for increasing the affinity of anionic dyestuffs for natural or synthetic fiber materials containing nitrogen or hydroxyl groups.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: September 22, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Kalk, Karl H. Schundehutte, Manfred Soll
  • Patent number: 4690707
    Abstract: The invention relates to N-pyridylsulfonyl-N'-pyrimidinyl- and -N'-triazinylureas of the formula I ##STR1## wherein A is a C.sub.3 -C.sub.6 alkynyl radical, a C.sub.1 -C.sub.6 alkyl radical which is substituted by halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 haloalkylsulfinyl or C.sub.1 -C.sub.4 haloalkylsulfonyl, or is a C.sub.2 -C.sub.4 alkenyl radical which is unsubstituted or substituted as for C.sub.1 -C.sub.6 alkyl, or is a phenyl radical which is unsubstituted or substituted by halogen, cyano, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, an --X--C.sub.1 --C.sub.4 --alkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, amino, mono- or di-(C.sub.1 -C.sub.4 alkyl)amino, carbamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)carbamoyl, sulfamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)sulfamoyl radical orA--X-- forms an amino radical --NR.sub.6 R.sub.
    Type: Grant
    Filed: October 4, 1985
    Date of Patent: September 1, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Karl Gass, Willy Meyer
  • Patent number: 4689414
    Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3 or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;R.sub.5 is hydrogen, alkyl, aryl, arylalkyl, cyano, nitro, ##STR2## Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl-(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR3## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR4## amino, or substituted amino; m is 0 or an integer of 1 to 6;n is an integer of 1 to 6; andp is an integer of 2 to 6.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: August 25, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Patent number: 4684656
    Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl--(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl--(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR2## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR3## Y.sub.3 is hydroxyl, alkoxy, aryl--(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl--(CH.sub.2).sub.
    Type: Grant
    Filed: March 14, 1986
    Date of Patent: August 4, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Patent number: 4683228
    Abstract: A guanidine derivative of the formula I: ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is substituted by a hydroxy radical and into which is optionally inserted, as part of the backbone of the chain, one or two groups selected from oxygen and sulphur atoms and NH and 1-6C N-alkyl radicals; and the pharmaceutically-acceptable acid additions salts thereof. Pharmaceutical compositions and methods of manufacture are also described. The compound of the formula I is a histamine H-2 antagonist and is therefore useful in ulcer therapy.
    Type: Grant
    Filed: January 22, 1985
    Date of Patent: July 28, 1987
    Assignees: ICI Americas Inc., Imperial Chemical Industries PLC
    Inventors: Karin M. Kirkland, Derrick M. Mant
  • Patent number: 4675353
    Abstract: Novel hindered 2-keto-1,4-diazacycloalkane-triazine oligomers having the general formula ##STR1## are useful antioxidants and UV stabilizers for various polymers.
    Type: Grant
    Filed: January 29, 1985
    Date of Patent: June 23, 1987
    Assignee: The BFGoodrich Company
    Inventors: Pyong-Nae Son, John T. Lai
  • Patent number: 4668281
    Abstract: Thiophenesulfonamides useful as herbicides and plant growth regulants, herbicidal compositions containing thiophenesulfonamides, and methods of applying the compositions to areas containing undesired vegetation are described.
    Type: Grant
    Filed: April 10, 1986
    Date of Patent: May 26, 1987
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: George Levitt
  • Patent number: 4656268
    Abstract: There are described novel cationic quinophthalone compounds of the formula I ##STR1## wherein the symbols have the meanings defined in claim 1, and also processes for producing them. These novel quinophthalone compounds can be used in particular as dyes for dyeing and printing paper, greenish-yellow dyeings having good fastness to water and to light being obtained.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: April 7, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Jean-Marie Adam
  • Patent number: 4652645
    Abstract: There are described novel cationic compounds of the formula ##STR1## wherein the symbols B and Z have the meanings defined in claim 1, and also processes for producing them and their use for dyeing and printing textile materials, such as polyacrylonitrile materials, leather and particularly paper, there being obtained greenish to reddish yellow dyeings which are distinguished by good general fastness properties.
    Type: Grant
    Filed: November 8, 1984
    Date of Patent: March 24, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Willy Stingelin, Jean-Marie Adam
  • Patent number: 4639479
    Abstract: A polyalkylenepolyamine ("PAPA") main chain having pendant substituted 2-oxo-piperazinyl-triazines attached to the N atoms of the PAPA main chain are novel compounds which have highly desirable UV-light stabilizing (UV-S) activity coupled with unexpectedly good thermal stability. These compounds, referred to as "pendant piperazinyl triazines" or P[PIP-T] for brevity, are used in polymer recipes to formulate a stabilized polymeric composition comprising a light-degradable organic polymer containing an effective amount of a P[PIP-T] sufficient to stabilize the polymer. A P[PIP-T] is especially effective in a polyolefin in which there is from about 0.1 percent by weight (% by wt), to about 5% by wt, and is also effective in a wide variety of pastel colored and/or transparent commercially significant polymers.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: January 27, 1987
    Assignee: The BFGoodrich Company
    Inventors: John T. Lai, Pyong N. Son
  • Patent number: 4639264
    Abstract: N-Arylsulfonyl-N'-(4-mercaptomethyl-pyrimidinyl- and -triazinyl)-ureas of the formula ##STR1## (symbols in this formula defined below) and the salts of these compounds with amines, alkali metal bases or alkaline-earth metal bases or with ammonium bases, have good pre- and post-emergence-selective, herbicidal and growth-regulating properties.
    Type: Grant
    Filed: August 15, 1984
    Date of Patent: January 27, 1987
    Assignee: Ciga-Geigy Corporation
    Inventor: Werner Topfl
  • Patent number: 4632695
    Abstract: N-Phenylsulfonyl-N'-triazinylureas of the general formula I ##STR1## and the salts of these compounds with amines, alkali metal bases or alkaline earth metal bases or with quaternary ammonium bases, have good selective herbicidal and growth regulating properties when applied pre- and postemergence. The symbols in formula I have the following meanings:R.sub.1 is hydrogen, halogen, nitro, cyano, or an alkyl, alkoxy, alkylthio, alkylsulfonyl, alkylcarbonyl, alkylcarbamoyl or alkoxycarbonyl group, each unsubstituted or substituted by halogen or alkoxy,R.sub.2 is hydrogen, halogen, alkyl, or an alkyl, alkoxy or alkylthio group, each unsubstituted or substituted by halogen or alkoxy,R.sub.3 is alkyl, haloalkyl, alkoxy or haloalkoxy,R.sub.4 is hydrogen, halogen, R.sub.3, alkylamino or dialkylamino,R.sub.
    Type: Grant
    Filed: December 6, 1985
    Date of Patent: December 30, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Rolf Schurter, Rudolph C. Thummel, Werner Topfl, Willy Meyer, Dieter Durr
  • Patent number: 4629752
    Abstract: A particular branched chain polyalkylenepolyamine ("PAPA") having plural amine groups including a secondary amine group intermediate terminal free primary amine groups (that is, neither one is hindered), and having at least two C atoms between each group, may be selectively cyclized with a ketoform reaction to form a polysubstituted piperazinone ("PSP"), with specific directivity. Such PSPs are linked to a triazine nucleus to yield piperazinone-triazine ("PIP-T") compounds which are excellent stabilizers for polyolefins and other light-degradable polymers. Certain acyclic polyalkylenepolyamines may have a PIP-T substituent at each N atom forming pendant PIP-Ts ("P[PIP-T]" for brevity) which are also excellent stabilizers, and like some of the PIP-Ts, some P[PIP-T]s provide photostabilization without noticeably interfering with the color of films and fibers provided by even pastel-colored pigments and dyes.
    Type: Grant
    Filed: July 22, 1985
    Date of Patent: December 16, 1986
    Assignee: The B. F. Goodrich Company
    Inventors: Robert W. Layer, John T. Lai, Pyong N. Son
  • Patent number: 4627873
    Abstract: N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g. N-[(4,6-dimethylpyrimidin-2-yl)-aminocarbonyl]-2-methoxycarbonylbenzenesul fonamide or N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-methoxycarbonylbenze nesulfonamide; are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.
    Type: Grant
    Filed: July 11, 1985
    Date of Patent: December 9, 1986
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: George Levitt
  • Patent number: 4624698
    Abstract: Disclosed herein is a derivative of tetrahydrobenzothiazolyl-1,3,5-triazinone represented by the formula (I): ##STR1## wherein R is a chemical group selected from the group consisting of 1-phenylethyl, 1-methylpropyl, 2-methylpropyl, allyl, 2-propynyl, cyclopropyl, cyclopentyl, phenyl, ethoxycarbonylmethyl, 2-tetrahydrofurylmethyl, 2-acetoxyethyl, 2-chloroethyl, 2-cyanoethyl, 2-hydroxyethyl, 2-methoxyethyl, 2,2-dimethoxyethyl, 2-(propionyloxy)ethyl, 2-(ethoxycarbonyl)ethyl, 2-(4-chlorobenzoyloxy)ethyl, 1-hydroxymethyl)propyl, 3-hydroxypropyl, 3-methoxypropyl, 3-acetoxypropyl, 3-morpholinopropyl and 3-(2-methylpiperidino)propyl, and a herbicidal composition containing the derivative as an active ingredient thereof.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: November 25, 1986
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Katsumichi Aoki, Takafumi Shida, Youichi Kanda, Keigo Satake, Shiro Yamazaki, Tsuneaki Chida
  • Patent number: 4616002
    Abstract: Compounds of the formula I ##STR1## in which n represents 1, 2 or 3, Ar represents a carbocyclic or heterocyclic aryl radical, Ac represents the acyl radical of an acid, Z represents a radical --OR.sub.7 or --NR.sub.8 R.sub.9, R.sub.1 represents hydrogen, unsubstituted or substituted lower alkyl, a carbocyclic or heterocyclic aryl radical or free, etherified or esterified hydroxy, R.sub.2 and R.sub.3, independently of one another, each represents hydrogen, unsubstituted or substituted lower alkyl, formyl or functionally modified formyl, carboxy or functionally modified carboxy, a carbocyclic or heterocyclic aryl radical or unsubstituted or mono- or di-substituted amino, R.sub.4 represents hydrogen or lower alkyl, R.sub.5 and R.sub.6, independently of one another, each represents hydrogen, unsubstituted or substituted lower alkyl or a carbocyclic or heterocyclic aryl radical, R.sub.7, R.sub.8 and R.sub.
    Type: Grant
    Filed: January 6, 1986
    Date of Patent: October 7, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Bruno Kamber, Thomas Leutert, Hans Kuhnis, Kurt Eichenberger
  • Patent number: 4601746
    Abstract: New substituted sulfonyl urea are disclosed of the general formula ##STR1## in which R.sub.1 is chlorine, --COOR.sub.5, --S(O).sub.n --R.sub.6 or ##STR2## R.sub.2 is ##STR3## or --CH.sub.2 --C.tbd.C--R.sub.11, R.sub.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkylthio, halogen, halogen-C.sub.1 -C.sub.4 -alkyl, halogen-C.sub.1 -C.sub.4 -alkoxy, Di-C.sub.1 -C.sub.3 -alkyl-amino, C.sub.1 -C.sub.3 -alkyl-amino or C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy,R.sub.4 is hydrogen C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, halogen, halogen-C.sub.1 -C.sub.4 -alkyl, halogen-C.sub.1 -C.sub.4 -alkoxy, Di-C.sub.1 -C.sub.3 -alkyl-amino, C.sub.1 -C.sub.3 -alkyl-amino, or C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy,Z is --CH.dbd. or --N.dbd.,R.sub.5 is C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkyl, phenyl, substituted phenyl, benzene or substituted benzene,R.sub.6 is C.sub.1 -C.sub.6 -alkyl or phenyl,R.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: July 22, 1986
    Assignee: Schering Aktiengesellschaft
    Inventors: Jurgen Westermann, Gerhard Boroschewski, Ulrich Eder, Friedrich Arndt, Hansjorg Krahmer, Clemens Kotter
  • Patent number: 4593026
    Abstract: Disubstituted polymethylene imines of the formula: ##STR1## in which: A is a straight or branched chain (C.sub.3 -C.sub.5) hydrocarbon containing radical optionally containing one or two double bond and optionally substituted by one or more hydroxy;n is zero, one or two;Z is oxygen or NH; andR is:either COR', in which R' is:(a) a straight or branched chain (C.sub.1 -C.sub.6), hydrocarbon containing radical, optionally containing one oxygen or sulfen or a double bond and optionally substituted by phenyl or substituted phenyl; or(b) phenyl, halophenyl, lower alkoxyphenyl, (di-or-tri-methylene) dioxyphenyl or;(c) furyl, thienyl, benzofuryl, benzothienyl or benzodioxannyl; or(d) ##STR2## in which R.sub.1 and R.sub.2 are hydrogen or lower alkyl or ##STR3## is a five or six membered heterocyclic radical which may contain an oxygen;or--SO.sub.2 R" in which R" is (C.sub.1 -C.sub.3) alkyl or phenyl.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: June 3, 1986
    Assignee: Adir, S.A.R.L.
    Inventors: Gilbert Regnier, Alain Dhainaut, Michel Laubie, Jacques Duhault, Francois Roman
  • Patent number: 4591378
    Abstract: N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g. N-[(4,6-dimethylpyrimidin-2-yl)-aminocarbonyl]-2-methoxycarbonylbenzenesul fonamide or N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-methoxycarbonylbenze nesulfonamide; are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.
    Type: Grant
    Filed: February 21, 1984
    Date of Patent: May 27, 1986
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: George Levitt
  • Patent number: 4579583
    Abstract: The invention relates to N-pyridylsulfonyl-N'-pyrimidinyl- and -N'-triazinylureas of the formula I ##STR1## wherein A is a C.sub.3 -C.sub.6 alkynyl radical, a C.sub.1 -C.sub.6 alkyl radical which is substituted by halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 haloalkylsulfinyl or C.sub.1 -C.sub.4 haloalkylsulfonyl, or is a C.sub.2 -C.sub.4 alkenyl radical which is unsubstituted or substituted as for C.sub.1 -C.sub.6 alkyl, or is a phenyl radical which is unsubstituted or substituted by halogen, cyano, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, an --X--C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, amino, mono- or di-(C.sub.1 -C.sub.4 alkyl)amino, carbamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)carbamoyl, sulfamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)sulfamoyl radical orA--X-- forms an amino radical --NR.sub.6 R.sub.
    Type: Grant
    Filed: August 29, 1983
    Date of Patent: April 1, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Karl Gass, Willy Meyer
  • Patent number: 4576633
    Abstract: Certain sulfonylurea compounds with oxysulfonyl-, thiosulfonyl- or aminosulfonyl-containing groups are useful as pre- and/or post-emergence herbicides.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: March 18, 1986
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: James J. Reap