1,3,5-triazine Ring Patents (Class 544/113)
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Patent number: 4838929Abstract: Sulfonamides such as N-[(4,6-dimethoxypyrimidin-2-aminocarbonyl]-1,3-dihydro-6-methyl-3-oxofuro [3,4-c]pyridine-4-sulfonamide are useful as herbicides and plant growth regulants.Type: GrantFiled: September 14, 1987Date of Patent: June 13, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventor: Mary A. Hanagan
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Patent number: 4837322Abstract: Mixtures of sulfurous triazine compounds and methods of preparing these compounds with the general formula ##STR1## in which R.sup.1, R.sup.2 =H,R.sup.2 =benzyl,R.sup.2, R.sup.3, R.sup.4 =C.sub.1 -C.sub.8 -alkyl, allyl, C.sub.3 -C.sub.8 cycloalkyl, the latter unsubstituted or substituted with 1-3 methyl groups, 2-hydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl orR.sup.3 and R.sup.4 (together): C.sub.4 -C.sub.6 -alkylene, --(CH.sub.2 --CHX).sub.2 Y withX=H, CH.sub.3, Y=O,S,S.sub.a : Polysulfide chain with 2-10 S atoms (i.e. 2.ltoreq.a.ltoreq.10), in which the individual polysulfides are present in such concentrations that the statistical average value of "a" is a whole or fractional numerical value in the range from 2 to 5., characterized in that a triazine compound of the general formula ##STR2## in which R.sup.1, R.sup.2, R.sup.3, R.sup.Type: GrantFiled: August 27, 1987Date of Patent: June 6, 1989Assignee: Degussa AktiengesellschaftInventors: Ulrich Deschler, Georg Hellwig, Rudolf Michel, Peter Kleinschmit, Siegfried Wolff
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Patent number: 4824834Abstract: Pyrazolotriazine compounds of the formula: ##STR1## wherein R.sup.1 is OH or alkanoyloxy; R.sup.2 is H, OH, or SH; R.sup.3 is (1) unsaturated N- or S-containing heterocyclic group optionally having 1-2 substituents of halogen, nitro or phenylthio, (2) naphthyl, (3) phenyl optionally having 1-3 substituents of (i) alkyl, (ii) phenyl, (iii) alkoxycarbonyl, (iv) cyano, (v) nitro, (vi) alkoxy, (vii) phenylalkoxy (viii) phenylthio-alkyl, (ix) phenoxy, (x) ##STR2## R is alkyl, halo-substituted alkyl, phenyl optionally having 1-3 substituents, or pyridyl, and l is 0, 1 or 2, (xi) halogen, (xii) phenylalkyl, (xiii) carboxy, (xiv) alkanoyl, (xv) benzoyl optionally having 1-3 substituents, (xvi) amino, (xvii) OH, (xviii) alkanoyloxy, (xix) ##STR3## or (xx) ##STR4## (A is alkylene), said compounds having a xanthine oxidase inhibitory activity and are useful for the prophylaxis and treatment of gout.Type: GrantFiled: October 8, 1987Date of Patent: April 25, 1989Assignee: Otsuka Pharmaceutical Company, LimitedInventors: Setsuro Fujii, Hiroyuki Kawamura, Hiroshi Kiyokawa, Satoshi Yamada
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Patent number: 4816507Abstract: Compounds of the formula (I) ##STR1## wherein R.sub.1 and R.sub.5 are independently hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl or a group of the formula (II), ##STR2## R.sub.2, R.sub.3 and R.sub.4 are independently C.sub.2 -C.sub.12 -alkylene, R is a group of the formula (III) ##STR3## wherein R.sub.6 is C.sub.2 -C.sub.8 -dialkylamino, C.sub.1 -C.sub.4 -alkoxy, a 5-membered to 7-membered heterocyclic group containing a nitrogen atom which is attached to the triazine residue or a group of the formula (IV), ##STR4## R.sub.7 and R.sub.8 are independently C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, benzyl or a group of the formula (II), subject to the proviso that both, R.sub.1 and R.sub.5 are different from hydrogen, if R is a group ##STR5## are useful as light stabilizers, heat stabilizers and/or oxidation stabilizers for organic materials, in particular synthetic polymers.Type: GrantFiled: August 14, 1987Date of Patent: March 28, 1989Assignee: Ciba-Geigy CorporationInventors: Erfinders G. Cantatore, Francois Gugumus
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Patent number: 4812161Abstract: Thia-diazole derivatives having the following partial structural formula had selective herbicidal activity on some crops.Type: GrantFiled: July 29, 1985Date of Patent: March 14, 1989Assignee: Nippon Soda Co., Ltd.Inventors: Kenji Hagiwara, Hisao Ishikawa, Hideo Hosaka, Hideo Inaba
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Patent number: 4802910Abstract: Novel herbicides of the formula ##STR1## in which R.sup.1 represents an organic radical,R.sup.2 represents hydrogen or an organic radical,R.sup.3 represents an organic radical or an amino radical,R.sup.4 represents hydrogen, an organic radical, an ether radical or an amino radical,X represents N or CH,Y and Z each represent N, CH or a substituted C radical, andM is H, a metal ion or an acyl radical, or a strong acid adduct thereof. Some intermediates are also new.Type: GrantFiled: January 20, 1987Date of Patent: February 7, 1989Assignee: Bayer AktiengesellschaftInventors: Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Theodor Pfister, Hans-Jochem Riebel, Hans-Joachim Santel, Robert R. Schmidt
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Patent number: 4788190Abstract: Novel 1,3-dioxolane compounds useful as antifungal and antiallergy agents and represented by the formula ##STR1## wherein Ar is thienyl, pyridyl, biphenyl, phenyl or phenyl substituted by one or more of halo, nitro, cyano, lower alkyl, lower alkoxy or perhalo(lower)alkyl; Y is CH or N;Q is ##STR2## W is --NR.sub.5 --, --O--, --S(O).sub.n --; X is NO.sub.2, NR.sub.6 R.sub.7 or COR.sub.8 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl or (C.sub.2 -C.sub.6) alkanoyl; R.sub.6 and R.sub.7 are independently hydrogen, lower alkyl, phenyl or phenyl substituted by one or more of halo, perhalo loweralkyl, (C.sub.2 -C.sub.6)alkanoyl lower alkyl, lower alkoxy or 2-loweralkyl-3-oxo-1,2,4-trirazol-4-yl or R.sub.6 and R.sub.7 taken together with the nitrogen atom in NR.sub.6 R.sub.7 form substituted or unsubstituted heterocyclyl, said heterocyclyl substituents being (C.sub.2 -C.sub.Type: GrantFiled: December 24, 1986Date of Patent: November 29, 1988Assignee: Schering CorporationInventors: Anil K. Saksena, Alan B. Cooper, Henry Guzik, Viyoor M. Girijavallabhan, Ashit K. Ganguly
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Patent number: 4786645Abstract: A compound of the general formula I: ##STR1## in which Ar is a pyridyl, quinolinyl, isoquinolinyl, naphthyridinyl, pyrimidyl, quinazolinyl, thiazolyl, benzothiazolyl, imidazolyl, benzimidazolyl, oxazolyl, benzoxazolyl, thienyl, benzothienyl or naphthyl group; optionally substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, alkylcarbonyl, benzoyl, alkyloxycarbonyl, carboxy, phenoxycarbonyl, alkylcabonyloxy, benzoyloxy, alkylcarbonylamino, benzamido, phenyl, benzyl, phenoxy or phenylthio group, provided that (i) when Ar is a pyridyl group, the pyridyl group must be substituted, (ii) an alkyl moiety contains 1 to 4 straight- or branched chain carbon atoms; (iii) a phenyl moiety may be unsubstituted or substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, phenyl or benzyl groupType: GrantFiled: July 2, 1987Date of Patent: November 22, 1988Assignee: Rhone-Poulenc SanteInventors: Jean-Louis Fabre, Claude James, Daniel Lave
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Patent number: 4786315Abstract: N-Arylsulfonyl-N'-(4-mercaptomethyl-pyrimidinyl- and -triazinyl)-ureas of the formula: ##STR1## and the salts of these compounds with amines, alkali metal bases or alkaline-earth metal bases or with ammonium bases, have good pre- and post-emergence-selective, herbicidal and growth-regulating properties.Type: GrantFiled: November 24, 1986Date of Patent: November 22, 1988Assignee: Ciba-Geigy CorporationInventor: Werner Topfl
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Patent number: 4786316Abstract: A class of ortho-sulfamoyl sulfonamides are useful as pre-emergent or post-emergent herbicides and plant growth regulants.Type: GrantFiled: December 12, 1986Date of Patent: November 22, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Chi-Ping Tseng
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Patent number: 4786311Abstract: Tetrazole-substituted benzenesulfonamides are useful as agricultural chemicals and, in particular, as growth regulants and herbicides.Type: GrantFiled: October 30, 1987Date of Patent: November 22, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4786313Abstract: The invention relates to certain pyridine sulfonamide compounds having haloalkenyl substituents ortho to the sulfonylurea linkage.Type: GrantFiled: October 23, 1987Date of Patent: November 22, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: James V. Hay, Barry A. Wexler, Donna F. Zimmerman
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Patent number: 4764205Abstract: This invention relates to herbicidal benzene sulfonamides containing a five or six membered heterocyclic ring consisting of 2-3 heteroatoms and 1-2 carbonyl groups as a substituent on benzene.Type: GrantFiled: June 19, 1987Date of Patent: August 16, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Morris P. Rorer
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Patent number: 4759790Abstract: This invention relates to herbicidally active sulfonamide compounds having a heterocyclic carbonyl group ortho to the sulfonyl bridge.Type: GrantFiled: May 21, 1987Date of Patent: July 26, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Joel R. Christensen
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Patent number: 4755211Abstract: This invention relates to herbicidally active sulfonamide compounds, agriculturally suitable compositions thereof and a method of their use as general and/or selective herbicides or plant growth regulants. More specifically the herbicidally active sulfonamides of this invention have an ortho cyclic saturated or partially saturated group which includes a carbonyl or sulfonyl radical.In the most common situation, the control of undesired vegetation is desired to permit the growth of useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such useful crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides are desired which will control all plant growth. Examples of areas in which complete control of all vegetation is desired and areas around fuel storage tanks, ammunition depots and industrial storage areas.Type: GrantFiled: January 29, 1987Date of Patent: July 5, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Mark E. Thompson
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Patent number: 4754032Abstract: Compounds of formula I ##STR1## can be used as optical brighteners.Type: GrantFiled: February 26, 1986Date of Patent: June 28, 1988Assignee: Sandoz Ltd.Inventors: David L. Connell, John M. Farrar, Jurg Heller, Hans-Rudolf Schmid
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Patent number: 4746356Abstract: This invention relates to novel sulfonylurea herbicidal compounds, agriculturally suitable compositions thereof and a method-of-use of said compounds and compositions as general preemergence and/or postemergence herbicides or their use as plant growth regulants.Type: GrantFiled: April 16, 1987Date of Patent: May 24, 1988Assignee: E. I. DuPont De Nemours and CompanyInventors: David L. Douglass, Marcus P. Moon
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Patent number: 4743294Abstract: A selective herbicide of the formula ##STR1## in which m is 0, 1 or 2,R.sup.5 is an organic radical,R.sup.3 is hydrogen or an organic radical,R.sup.9 is hydrogen or an optionally substituted alkyl radical,R.sup.10 is an organic radical or forms a ring with R.sup.9,R.sup.40 and R.sup.41 are alkyl or alkoxy, andM is hydrogen or a metal or ammonium radical, or an acid adduct thereof.Type: GrantFiled: April 22, 1987Date of Patent: May 10, 1988Assignee: Bayer AktiengesellschaftInventors: Hans-Joachim Diehr, Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Theodor Pfister, Uwe Priesnitz, Hans-Jochem Riebel, Wolfgang Roy, Hans-Joachim Santel, Robert R. Schmidt, Koichi Moriya, Ludwig Eue, Klaus Lurssen
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Patent number: 4743295Abstract: Thiocarbonylsulfonylureas, useful as herbicides and plant growth regulants, herbicidal compositions employing these compounds and methods of applying them to soil or directly to plants have been discovered.Type: GrantFiled: March 20, 1987Date of Patent: May 10, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Wallace C. Petersen
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Patent number: 4743688Abstract: Poly-2,2,6,6 tetramethyl piperidyl amino spiro glycol ether-1,3,5-triazines are provided having the formula: ##STR1## in which: R is selected from the group consisting of hydrogen, alkyl having from one to about eighteen carbon atoms, hydroxyalkyl having from two to about six carbon atoms; epoxyalkyl having from three to about eight carbon atoms; alkylaryl having from seven to about eighteen carbon atoms; acyl having from two to about eight carbon atoms; and oxyl;each of R.sub.1 and R.sub.2 is selected from the group consisting of hydrogen, alkyl having from one to about eighteen carbon atoms; and alkylene forming a heterocyclic ring including the nitrogen atom in the ring and having from four to seven carbon atoms and no or one oxygen atom; andn is a number from 2 to about 40 representing the average number of units enclosed by the brackets; and synthetic resin compositions containing the same as light stabilizers.Type: GrantFiled: September 2, 1986Date of Patent: May 10, 1988Assignee: Adeka Argus Chemical Co., Ltd.Inventors: Motonobu Minagawa, Yutaka Nakahara, Toshihiro Shibata, Etsuo Tobita
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Patent number: 4741765Abstract: Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide, agricultural compositions containing them, and their herbicidal utility are disclosed.Type: GrantFiled: April 3, 1987Date of Patent: May 3, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: Robert J. Pasteris, Ramaurthi Muthukrishnan
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Patent number: 4734413Abstract: Substituted 1,2,4-triazolo[1,5-a]triazines as bronchodilators are disclosed. Pharmaceutical formulations comprising such compounds and pharmacological methods of using such compounds are also described.Type: GrantFiled: March 2, 1987Date of Patent: March 29, 1988Assignee: Riker Laboratories, Inc.Inventor: James J. Wade
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Patent number: 4725305Abstract: Herbicidally active novel N,N'-bis-sulphonyl guanidines of the formula ##STR1## in which M is hydrogen, a metal or an ammonium radical, andR.sup.4, R.sup.5, R.sup.40 and R.sup.41 are various organic radicals.Type: GrantFiled: November 14, 1986Date of Patent: February 16, 1988Assignee: Bayer AktiengesellschaftInventors: Koichi Moriya, Theodor Pfister, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt, Klaus Lurssen, Hans-Joachim Diehr, Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Uwe Priesnitz, Wolfgang Roy, Hans-Joachim Santel
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Patent number: 4723990Abstract: o-Haloalkylbenzene sulfonylureas are useful as herbicides.Type: GrantFiled: January 23, 1987Date of Patent: February 9, 1988Assignee: E. I. DuPont De Nemours and Co.Inventor: William B. Farnham
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Patent number: 4723988Abstract: Thiophenesulfonamides such as N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-3-(isoxazol-3-yl)-2-thiophen esulfonamide are useful as herbicides and plant growth regulants.Type: GrantFiled: March 27, 1987Date of Patent: February 9, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Rafael Shapiro
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Patent number: 4718938Abstract: Ortho-Hydrazinosulfonyl benzenesulfonylureas, such as 2-(2,2-dimethylhydrazinosulfonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocar bonyl]benzenesulfonamide, are useful as pre-emergent and post-emergent herbicides.Type: GrantFiled: December 4, 1986Date of Patent: January 12, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Donald J. Dumas
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Patent number: 4707178Abstract: Herbicidally active pyrazolesulfonamide compounds having an ortho cyclic saturated or partially saturated group which includes a carbonyl or sulfonyl radical having utility as herbicides and plant growth regulants.Type: GrantFiled: December 22, 1986Date of Patent: November 17, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Mark E. Thompson
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Patent number: 4707179Abstract: Herbicidally active pyridinesulfonamide compounds having an ortho cyclic saturated or partially saturated group which includes a carbonyl or sulfonyl radical display utility as herbicides and plant growth regulants.Type: GrantFiled: February 17, 1987Date of Patent: November 17, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Mark E. Thompson
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Patent number: 4698352Abstract: This invention relates to a novel 4-oxo-1,4-dihydronicotinic acid derivative ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen or carboxyl-protecting group;R.sup.2 is substituted phenyl and naphthyl, or a substituted or unsubstituted heterocyclic group; andR.sup.3 is haloalkyl, aminoalkyl, or substituted or unsubstituted alkenyl, phenylalkenyl, naphthylalkenyl, phenylalkyl, naphthylalkyl, phenylalkynyl, naphthylalkynyl, heterocyclic alkyl, heterocyclic alkenyl, phenyl, naphthyl, cycloalkyl, cycloalkenyl, carboxylic acyl, iminoalkyl, heterocyclic or bridged hydrocarbon, which has a broad antibacterial spectrum and a low toxicity, and are useful for treatment of diseases of human beings and animals, to a process for producing the same and to an antibacterial agent containing the same.Type: GrantFiled: October 27, 1983Date of Patent: October 6, 1987Assignee: Toyama Chemical Co., Ltd.Inventors: Hirokazu Narita, Yoshinori Konishi, Jun Nitta, Shunjiro Misumi, Hideyoshi Nagaki, Isao Kitayama, Yoriko Nagai, Yasuo Watanabe, Nobuyuki Matsubara, Shinzaburo Minami, Isamu Saikawa
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Patent number: 4695632Abstract: Quaternary compounds of the formula ##STR1## wherein K.sym. denotes a cationic organic radical,X denotes a linking member,R denotes the radical of a heterocyclic reactive group,m denotes the numbers 1 or 2,n denotes the numbers 1 or 2 andAn.crclbar. denotes an anion,can be used for increasing the affinity of anionic dyestuffs for natural or synthetic fiber materials containing nitrogen or hydroxyl groups.Type: GrantFiled: February 23, 1979Date of Patent: September 22, 1987Assignee: Bayer AktiengesellschaftInventors: Walter Kalk, Karl H. Schundehutte, Manfred Soll
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Patent number: 4690707Abstract: The invention relates to N-pyridylsulfonyl-N'-pyrimidinyl- and -N'-triazinylureas of the formula I ##STR1## wherein A is a C.sub.3 -C.sub.6 alkynyl radical, a C.sub.1 -C.sub.6 alkyl radical which is substituted by halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 haloalkylsulfinyl or C.sub.1 -C.sub.4 haloalkylsulfonyl, or is a C.sub.2 -C.sub.4 alkenyl radical which is unsubstituted or substituted as for C.sub.1 -C.sub.6 alkyl, or is a phenyl radical which is unsubstituted or substituted by halogen, cyano, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, an --X--C.sub.1 --C.sub.4 --alkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, amino, mono- or di-(C.sub.1 -C.sub.4 alkyl)amino, carbamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)carbamoyl, sulfamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)sulfamoyl radical orA--X-- forms an amino radical --NR.sub.6 R.sub.Type: GrantFiled: October 4, 1985Date of Patent: September 1, 1987Assignee: Ciba-Geigy CorporationInventors: Werner Fory, Karl Gass, Willy Meyer
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Patent number: 4689414Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3 or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;R.sub.5 is hydrogen, alkyl, aryl, arylalkyl, cyano, nitro, ##STR2## Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl-(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR3## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR4## amino, or substituted amino; m is 0 or an integer of 1 to 6;n is an integer of 1 to 6; andp is an integer of 2 to 6.Type: GrantFiled: February 24, 1986Date of Patent: August 25, 1987Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Patent number: 4684656Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl--(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl--(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR2## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR3## Y.sub.3 is hydroxyl, alkoxy, aryl--(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl--(CH.sub.2).sub.Type: GrantFiled: March 14, 1986Date of Patent: August 4, 1987Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Patent number: 4683228Abstract: A guanidine derivative of the formula I: ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is substituted by a hydroxy radical and into which is optionally inserted, as part of the backbone of the chain, one or two groups selected from oxygen and sulphur atoms and NH and 1-6C N-alkyl radicals; and the pharmaceutically-acceptable acid additions salts thereof. Pharmaceutical compositions and methods of manufacture are also described. The compound of the formula I is a histamine H-2 antagonist and is therefore useful in ulcer therapy.Type: GrantFiled: January 22, 1985Date of Patent: July 28, 1987Assignees: ICI Americas Inc., Imperial Chemical Industries PLCInventors: Karin M. Kirkland, Derrick M. Mant
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Patent number: 4675353Abstract: Novel hindered 2-keto-1,4-diazacycloalkane-triazine oligomers having the general formula ##STR1## are useful antioxidants and UV stabilizers for various polymers.Type: GrantFiled: January 29, 1985Date of Patent: June 23, 1987Assignee: The BFGoodrich CompanyInventors: Pyong-Nae Son, John T. Lai
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Patent number: 4668281Abstract: Thiophenesulfonamides useful as herbicides and plant growth regulants, herbicidal compositions containing thiophenesulfonamides, and methods of applying the compositions to areas containing undesired vegetation are described.Type: GrantFiled: April 10, 1986Date of Patent: May 26, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4656268Abstract: There are described novel cationic quinophthalone compounds of the formula I ##STR1## wherein the symbols have the meanings defined in claim 1, and also processes for producing them. These novel quinophthalone compounds can be used in particular as dyes for dyeing and printing paper, greenish-yellow dyeings having good fastness to water and to light being obtained.Type: GrantFiled: October 18, 1985Date of Patent: April 7, 1987Assignee: Ciba-Geigy CorporationInventor: Jean-Marie Adam
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Patent number: 4652645Abstract: There are described novel cationic compounds of the formula ##STR1## wherein the symbols B and Z have the meanings defined in claim 1, and also processes for producing them and their use for dyeing and printing textile materials, such as polyacrylonitrile materials, leather and particularly paper, there being obtained greenish to reddish yellow dyeings which are distinguished by good general fastness properties.Type: GrantFiled: November 8, 1984Date of Patent: March 24, 1987Assignee: Ciba-Geigy CorporationInventors: Willy Stingelin, Jean-Marie Adam
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Patent number: 4639479Abstract: A polyalkylenepolyamine ("PAPA") main chain having pendant substituted 2-oxo-piperazinyl-triazines attached to the N atoms of the PAPA main chain are novel compounds which have highly desirable UV-light stabilizing (UV-S) activity coupled with unexpectedly good thermal stability. These compounds, referred to as "pendant piperazinyl triazines" or P[PIP-T] for brevity, are used in polymer recipes to formulate a stabilized polymeric composition comprising a light-degradable organic polymer containing an effective amount of a P[PIP-T] sufficient to stabilize the polymer. A P[PIP-T] is especially effective in a polyolefin in which there is from about 0.1 percent by weight (% by wt), to about 5% by wt, and is also effective in a wide variety of pastel colored and/or transparent commercially significant polymers.Type: GrantFiled: September 20, 1985Date of Patent: January 27, 1987Assignee: The BFGoodrich CompanyInventors: John T. Lai, Pyong N. Son
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Patent number: 4639264Abstract: N-Arylsulfonyl-N'-(4-mercaptomethyl-pyrimidinyl- and -triazinyl)-ureas of the formula ##STR1## (symbols in this formula defined below) and the salts of these compounds with amines, alkali metal bases or alkaline-earth metal bases or with ammonium bases, have good pre- and post-emergence-selective, herbicidal and growth-regulating properties.Type: GrantFiled: August 15, 1984Date of Patent: January 27, 1987Assignee: Ciga-Geigy CorporationInventor: Werner Topfl
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Patent number: 4632695Abstract: N-Phenylsulfonyl-N'-triazinylureas of the general formula I ##STR1## and the salts of these compounds with amines, alkali metal bases or alkaline earth metal bases or with quaternary ammonium bases, have good selective herbicidal and growth regulating properties when applied pre- and postemergence. The symbols in formula I have the following meanings:R.sub.1 is hydrogen, halogen, nitro, cyano, or an alkyl, alkoxy, alkylthio, alkylsulfonyl, alkylcarbonyl, alkylcarbamoyl or alkoxycarbonyl group, each unsubstituted or substituted by halogen or alkoxy,R.sub.2 is hydrogen, halogen, alkyl, or an alkyl, alkoxy or alkylthio group, each unsubstituted or substituted by halogen or alkoxy,R.sub.3 is alkyl, haloalkyl, alkoxy or haloalkoxy,R.sub.4 is hydrogen, halogen, R.sub.3, alkylamino or dialkylamino,R.sub.Type: GrantFiled: December 6, 1985Date of Patent: December 30, 1986Assignee: Ciba-Geigy CorporationInventors: Rolf Schurter, Rudolph C. Thummel, Werner Topfl, Willy Meyer, Dieter Durr
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Patent number: 4629752Abstract: A particular branched chain polyalkylenepolyamine ("PAPA") having plural amine groups including a secondary amine group intermediate terminal free primary amine groups (that is, neither one is hindered), and having at least two C atoms between each group, may be selectively cyclized with a ketoform reaction to form a polysubstituted piperazinone ("PSP"), with specific directivity. Such PSPs are linked to a triazine nucleus to yield piperazinone-triazine ("PIP-T") compounds which are excellent stabilizers for polyolefins and other light-degradable polymers. Certain acyclic polyalkylenepolyamines may have a PIP-T substituent at each N atom forming pendant PIP-Ts ("P[PIP-T]" for brevity) which are also excellent stabilizers, and like some of the PIP-Ts, some P[PIP-T]s provide photostabilization without noticeably interfering with the color of films and fibers provided by even pastel-colored pigments and dyes.Type: GrantFiled: July 22, 1985Date of Patent: December 16, 1986Assignee: The B. F. Goodrich CompanyInventors: Robert W. Layer, John T. Lai, Pyong N. Son
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Patent number: 4627873Abstract: N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g. N-[(4,6-dimethylpyrimidin-2-yl)-aminocarbonyl]-2-methoxycarbonylbenzenesul fonamide or N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-methoxycarbonylbenze nesulfonamide; are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.Type: GrantFiled: July 11, 1985Date of Patent: December 9, 1986Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4624698Abstract: Disclosed herein is a derivative of tetrahydrobenzothiazolyl-1,3,5-triazinone represented by the formula (I): ##STR1## wherein R is a chemical group selected from the group consisting of 1-phenylethyl, 1-methylpropyl, 2-methylpropyl, allyl, 2-propynyl, cyclopropyl, cyclopentyl, phenyl, ethoxycarbonylmethyl, 2-tetrahydrofurylmethyl, 2-acetoxyethyl, 2-chloroethyl, 2-cyanoethyl, 2-hydroxyethyl, 2-methoxyethyl, 2,2-dimethoxyethyl, 2-(propionyloxy)ethyl, 2-(ethoxycarbonyl)ethyl, 2-(4-chlorobenzoyloxy)ethyl, 1-hydroxymethyl)propyl, 3-hydroxypropyl, 3-methoxypropyl, 3-acetoxypropyl, 3-morpholinopropyl and 3-(2-methylpiperidino)propyl, and a herbicidal composition containing the derivative as an active ingredient thereof.Type: GrantFiled: January 25, 1985Date of Patent: November 25, 1986Assignee: Kureha Kagaku Kogyo Kabushiki KaishaInventors: Katsumichi Aoki, Takafumi Shida, Youichi Kanda, Keigo Satake, Shiro Yamazaki, Tsuneaki Chida
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Patent number: 4616002Abstract: Compounds of the formula I ##STR1## in which n represents 1, 2 or 3, Ar represents a carbocyclic or heterocyclic aryl radical, Ac represents the acyl radical of an acid, Z represents a radical --OR.sub.7 or --NR.sub.8 R.sub.9, R.sub.1 represents hydrogen, unsubstituted or substituted lower alkyl, a carbocyclic or heterocyclic aryl radical or free, etherified or esterified hydroxy, R.sub.2 and R.sub.3, independently of one another, each represents hydrogen, unsubstituted or substituted lower alkyl, formyl or functionally modified formyl, carboxy or functionally modified carboxy, a carbocyclic or heterocyclic aryl radical or unsubstituted or mono- or di-substituted amino, R.sub.4 represents hydrogen or lower alkyl, R.sub.5 and R.sub.6, independently of one another, each represents hydrogen, unsubstituted or substituted lower alkyl or a carbocyclic or heterocyclic aryl radical, R.sub.7, R.sub.8 and R.sub.Type: GrantFiled: January 6, 1986Date of Patent: October 7, 1986Assignee: Ciba-Geigy CorporationInventors: Bruno Kamber, Thomas Leutert, Hans Kuhnis, Kurt Eichenberger
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Patent number: 4601746Abstract: New substituted sulfonyl urea are disclosed of the general formula ##STR1## in which R.sub.1 is chlorine, --COOR.sub.5, --S(O).sub.n --R.sub.6 or ##STR2## R.sub.2 is ##STR3## or --CH.sub.2 --C.tbd.C--R.sub.11, R.sub.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkylthio, halogen, halogen-C.sub.1 -C.sub.4 -alkyl, halogen-C.sub.1 -C.sub.4 -alkoxy, Di-C.sub.1 -C.sub.3 -alkyl-amino, C.sub.1 -C.sub.3 -alkyl-amino or C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy,R.sub.4 is hydrogen C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, halogen, halogen-C.sub.1 -C.sub.4 -alkyl, halogen-C.sub.1 -C.sub.4 -alkoxy, Di-C.sub.1 -C.sub.3 -alkyl-amino, C.sub.1 -C.sub.3 -alkyl-amino, or C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy,Z is --CH.dbd. or --N.dbd.,R.sub.5 is C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkyl, phenyl, substituted phenyl, benzene or substituted benzene,R.sub.6 is C.sub.1 -C.sub.6 -alkyl or phenyl,R.Type: GrantFiled: June 18, 1984Date of Patent: July 22, 1986Assignee: Schering AktiengesellschaftInventors: Jurgen Westermann, Gerhard Boroschewski, Ulrich Eder, Friedrich Arndt, Hansjorg Krahmer, Clemens Kotter
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Anti-hypoxic disubstituted polymethylene imine derivatives, compositions, and method of use therefor
Patent number: 4593026Abstract: Disubstituted polymethylene imines of the formula: ##STR1## in which: A is a straight or branched chain (C.sub.3 -C.sub.5) hydrocarbon containing radical optionally containing one or two double bond and optionally substituted by one or more hydroxy;n is zero, one or two;Z is oxygen or NH; andR is:either COR', in which R' is:(a) a straight or branched chain (C.sub.1 -C.sub.6), hydrocarbon containing radical, optionally containing one oxygen or sulfen or a double bond and optionally substituted by phenyl or substituted phenyl; or(b) phenyl, halophenyl, lower alkoxyphenyl, (di-or-tri-methylene) dioxyphenyl or;(c) furyl, thienyl, benzofuryl, benzothienyl or benzodioxannyl; or(d) ##STR2## in which R.sub.1 and R.sub.2 are hydrogen or lower alkyl or ##STR3## is a five or six membered heterocyclic radical which may contain an oxygen;or--SO.sub.2 R" in which R" is (C.sub.1 -C.sub.3) alkyl or phenyl.Type: GrantFiled: April 6, 1984Date of Patent: June 3, 1986Assignee: Adir, S.A.R.L.Inventors: Gilbert Regnier, Alain Dhainaut, Michel Laubie, Jacques Duhault, Francois Roman -
Patent number: 4591378Abstract: N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g. N-[(4,6-dimethylpyrimidin-2-yl)-aminocarbonyl]-2-methoxycarbonylbenzenesul fonamide or N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-methoxycarbonylbenze nesulfonamide; are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.Type: GrantFiled: February 21, 1984Date of Patent: May 27, 1986Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4579583Abstract: The invention relates to N-pyridylsulfonyl-N'-pyrimidinyl- and -N'-triazinylureas of the formula I ##STR1## wherein A is a C.sub.3 -C.sub.6 alkynyl radical, a C.sub.1 -C.sub.6 alkyl radical which is substituted by halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 haloalkylsulfinyl or C.sub.1 -C.sub.4 haloalkylsulfonyl, or is a C.sub.2 -C.sub.4 alkenyl radical which is unsubstituted or substituted as for C.sub.1 -C.sub.6 alkyl, or is a phenyl radical which is unsubstituted or substituted by halogen, cyano, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, an --X--C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, amino, mono- or di-(C.sub.1 -C.sub.4 alkyl)amino, carbamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)carbamoyl, sulfamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)sulfamoyl radical orA--X-- forms an amino radical --NR.sub.6 R.sub.Type: GrantFiled: August 29, 1983Date of Patent: April 1, 1986Assignee: Ciba-Geigy CorporationInventors: Werner Fory, Karl Gass, Willy Meyer
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Patent number: 4576633Abstract: Certain sulfonylurea compounds with oxysulfonyl-, thiosulfonyl- or aminosulfonyl-containing groups are useful as pre- and/or post-emergence herbicides.Type: GrantFiled: February 1, 1985Date of Patent: March 18, 1986Assignee: E. I. Du Pont de Nemours and CompanyInventor: James J. Reap