Phenothiazines (including Hydrogenated) Patents (Class 544/35)
  • Patent number: 10537578
    Abstract: This disclosure pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). Also disclosed resulting (high purity) compounds, compositions comprising them (e.g.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 21, 2020
    Inventors: John Mervyn David Storey, James Peter Sinclair, Colin Marshall, Han Wan Tan, Claude Michel Wischik
  • Patent number: 10333078
    Abstract: An organic light-emitting element which emits delayed fluorescence comprising specifically substituted 1,2,4-triazole derivatives, 1,2,4-oxadiazole derivatives or 1,2,4-thiadiazole derivatives in the light-emitting layer, a light-emitting layer comprising the specifically substituted 1,2,4-triazole derivatives, 1,2,4-oxadiazole derivatives or 1,2,4-thiadiazole derivatives, specific specifically substituted 1,2,4-triazole derivatives, 1,2,4-oxadiazole derivatives and 1,2,4-thiadiazole derivatives and an organic light emitting element comprising the specific 1,2,4-azole derivatives as well as a light emitting layer comprising the specific 1,2,4-azole derivatives; the use of the specifically substituted 1,2,4-triazole derivatives, 1,2,4-oxadiazole derivatives and 1,2,4-thiadiazole derivatives for electrophotographic photoreceptors, photoelectric converters, sensors, dye lasers, solar cell devices and organic light emitting elements, and the use of the specifically substituted 1,2,4-triazole derivatives, 1,2,4-ox
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: June 25, 2019
    Assignee: UDC IRELAND LIMITED
    Inventors: Junichi Tanabe, Christian Lennartz
  • Patent number: 10173968
    Abstract: Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: January 8, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, David S. Watt
  • Patent number: 9935272
    Abstract: A compound represented by the following general formula (1) is useful as a light-emitting material. Y1 and Y2 each independently represent N or C(R7); and R1 to R7 each independently represent a hydrogen atom or a substituent, provided that at least one of R1 and R2, and at least one of R5 and R6 represent a group represented by the following general formula (2). Z represent a divalent linking group having a linking chain length of 1 atom; L1 represents a single bond or a substituted or unsubstituted arylene group; and R11 to R18 each independently represent a hydrogen atom or a substituent.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: April 3, 2018
    Assignee: KYULUX, INC.
    Inventors: Hirokazu Kuwabara, Chihaya Adachi
  • Patent number: 9632034
    Abstract: The present invention provides near-infrared fluorogenic and/or chromogenic formulations, methods, systems and kits. Upon contacting an azine with an oxidant and a peroxidase, the azine is converted to an azine derivative which is both visibly colored and fluorescent. This invention also provides high sensitive methods to detect biological molecules, showing better sensitivity than chemiluminescence methods. Advantageously, the formulation and reaction is free of luminol or luminol derivatives.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 25, 2017
    Assignee: LI-COR, Inc.
    Inventors: Ying Wang, Xinshe Xu, Nisha Padhye
  • Patent number: 9555043
    Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallization (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: January 31, 2017
    Assignee: WisTa Laboratories Ltd.
    Inventors: John Mervyn David Storey, James Peter Sinclair, Colin Marshall, Han Wan Tan, Claude Michel Wischik
  • Patent number: 9504692
    Abstract: The invention relates to a compound for use in treating a cancer, wherein the cancer depends on the proteolytic activity of the MALT1 protease, and wherein the compound has the general formula (I) wherein X is N or C; Y is S, O, SO2, SO, NH, CO, CH2, CH?CH, or CH2—CH2; ( )z is a C1-C5 linear or branched alkyl chain; A is NR3R4, or OR5, or HET; R1 and R2 in each occurrence are independently selected from —H, —CH3, —OH, —OCH3, —SCH3, —F, —Cl, —CF3, —NH2, and —COOH; R3, R4, and R5 are H, or C1-C5 linear or branched alkyl groups, and HET is a heterocyclic ring of 5, 6, or 7 members, wherein the ring atoms can be C, O, N, or S, the ring can be saturated or aromatic, and the ring can be substituted with H or C1-C5 linear or branched alkyl groups; or a pharmaceutically acceptable salt, prodrug, enantiomer, diastereomer, racemic mixture, crystalline form, amorphous form, unsolvated form or solvate of said compound.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: November 29, 2016
    Assignee: HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)
    Inventors: Daniel Krappmann, Daniel Nagel, Dolores Schendel, Stefani Spranger
  • Publication number: 20150087754
    Abstract: A condensed heterocyclic compound which is shown by the following formula (I) and a composition containing an (a) organic material and (b) at least one type of the condensed heterocyclic compound are provided. (Y indicates a chemical single bond, —S(?O)—, or —SO2—. Ra and Rb indicate substitutable C1 to C30 organic groups. Za and Zb indicate chemical single bonds or —SO2—. X1 and X2 indicate hydrogen atoms etc. n and m respectively independently indicate integers of 0 to 2, where one of n and m is not 0).
    Type: Application
    Filed: December 4, 2014
    Publication date: March 26, 2015
    Applicant: ZEON CORPORATION
    Inventors: Kei SAKAMOTO, Satoshi KIRIKI, Tomonori OGAWA, Masanobu SHINOHARA
  • Patent number: 8937121
    Abstract: A condensed heterocyclic compound which is shown by the following formula (I) and a composition containing an (a) organic material and (b) at least one type of the condensed heterocyclic compound are provided. (Y indicates a chemical single bond, —S(?O)—, or —SO2—. Ra and Rb indicate substitutable C1 to C30 organic groups. Za and Zb indicate chemical single bonds or —SO2—. X1 and X2 indicate hydrogen atoms etc. n and m respectively independently indicate integers of 0 to 2, where one of n and m is not 0).
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: January 20, 2015
    Assignee: Zeon Corporation
    Inventors: Kei Sakamoto, Satoshi Kiriki, Tomonori Ogawa, Masanobu Shinohara
  • Publication number: 20140272707
    Abstract: A sulfonium salt having formula (1a) is provided wherein R1 is H, F, CH3 or CF3, R1a to R1m are each independently H or a monovalent hydrocarbon group, L is a single bond or divalent hydrocarbon group, X is a divalent alkylene group optionally substituted with fluorine, and n is 0 or 1. The sulfonium salt having a polymerizable anion provides for efficient scission of acid labile groups in a chemically amplified resist composition, and it is a very useful monomer from which a base resin for resist use is prepared.
    Type: Application
    Filed: February 4, 2014
    Publication date: September 18, 2014
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Masahiro Fukushima, Jun Hatakeyama, Masaki Ohashi, Teppei Adachi
  • Publication number: 20140275045
    Abstract: Disclosed herein are phenazine-3-one and phenothiazine-3-one derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: EDISON PHARMACEUTICALS, INC.
    Inventors: Andrew W. HINMAN, Dana Davis, William D. Shrader
  • Patent number: 8828986
    Abstract: Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: September 9, 2014
    Assignee: Prosetta Antiviral Inc.
    Inventors: Clarence Hurt, Andy Atuegbu, Anatoliy Kitaygorodskyy, Beverly Freeman, Vishwanath Lingappa
  • Patent number: 8809317
    Abstract: Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: August 19, 2014
    Assignee: Prosetta Antiviral Inc.
    Inventors: Clarence R. Hurt, Vishwanath Lingappa, Beverly Freeman, Andy Atuegbu, Anatoliy Kitaygorodskyy
  • Patent number: 8796448
    Abstract: Novel methods and compounds for treating Alzheimer's Disease are provided. In one aspect, the invention provides methods for treating Alzheimer's Disease by administering certain phenothiazine derivatives. In one embodiment, the methods include administering an effective amount of a 3-oxo-7-dialkyl-amino-phenothiazine derivative, or 3-oxo-7-dialkyl-amino-phenothiazine. In another embodiment, the invention provides methods for treating Alzheimer's Disease by administering an effective amount of a 3,7-diazetidin-1-yl-phenothiazine or a derivative thereof. In another aspect, the invention provides novel azetidinyl phenothiazine compounds.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: August 5, 2014
    Assignee: Prosetta Antiviral Inc.
    Inventors: Vishwanath Lingappa, Clarence R. Hurt
  • Publication number: 20140070146
    Abstract: The present application relates to a compound of a formula (I), to the use of this compound in an electronic device, and to an electronic device comprising one or more compounds of the formula (I). The invention furthermore relates to the preparation of the compound of the formula (I) and to a formulation comprising one or more compounds of the formula (I).
    Type: Application
    Filed: April 12, 2012
    Publication date: March 13, 2014
    Applicant: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Arne Buesing, Christof Pflumm, Teresa Mujica-Fernaud, Philipp Stoessel, Thomas Eberle
  • Publication number: 20140058099
    Abstract: The compounds represented fey the following general formula is is thermally stable and has excellent characteristics as a charge transport material [Ar1 represents a single bond, a benzene ring, etc.; X1 represents a linking group that links via an oxygen atom, a sulfur atom, a carbon atom, a nitrogen atom, a phosphorus atom or a silicon atom; either one of L1 and L2, and L3 and L4 bond to each other to represent a linking group that links via an oxygen atom, a sulfur atom, a carbon atom, a nitrogen atom, a phosphorus atom or a silicon atom; the other of L1 and L2, and L3 and L4 represent a hydrogen atom or a substituent; Y1 represents a linking group that links via a nitrogen atom, a boron atom or a phosphorus atom; R1, R2, R5 to R7 and R10 to R12 represent a hydrogen atom or a substituent; and n1 indicates an integer of 2 or more.].
    Type: Application
    Filed: March 2, 2012
    Publication date: February 27, 2014
    Applicant: KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION
    Inventors: Atsushi Wakamiya, Hidetaka Nishimura, Yasujiro Murata, Tatsuya Fukushima, Hironori Kaji
  • Patent number: 8637602
    Abstract: A stable viscosity coating composition, a method of forming the stable viscosity coating composition and a method for using the stable viscosity coating composition in a micro-molding imprint lithographic process, such as Step and Flash Imprint Lithography is disclosed. The stable viscosity coating composition may include at least one vinyl ether having at least one vinyl ether group (—OCR?CR2), and a stabilizer, wherein the stabilizer may be 9-anthracenemethanol, a substituted 9-anthracenemethanol, phenothiazine, or a substituted phenothiazine. The coating composition may include a radiation sensitive photoacid generator (PAG). The method of forming the coating composition comprises combining at least one vinyl ether having at least one vinyl ether group (—OCR?CR2), and at least one stabilizer.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: January 28, 2014
    Assignee: International Business Machines Corporation
    Inventors: Frances Anne Houle, Hiroshi Ito
  • Patent number: 8629269
    Abstract: The present invention relates to a dye for a dye-sensitized solar cell. The dye according to the present invention has a high degree of light absorbency and can improve the photoelectric current conversion efficiency when employed in a light-absorbing layer for a solar cell. Chemical Formula 1 illustrates the present invention. wherein X1, X2, N, Z1, and A1 are described herein.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: January 14, 2014
    Assignee: Solarsys Co., Ltd.
    Inventors: Kwang-Yol Kay, Kang-Jin Kim, Jong-Hyung Kim, Young-Jin Kwon
  • Publication number: 20130324716
    Abstract: The composition described here comprises at least one hole-transporting compound, wherein the hole-transporting compound comprises a core covalently bonded to at least two arylamine groups, wherein the arylamine group optionally comprises one or more intractability groups. The composition can provide good film formation and stability when coated onto hole injection layers. Solution processing of hole transporting layers of OLEDs can be achieved with the composition described here. Good mobility can be achieved.
    Type: Application
    Filed: May 14, 2013
    Publication date: December 5, 2013
    Applicant: Plextronics, Inc.
    Inventors: Christopher T. BROWN, Jing WANG, Christophe Rene Gaston GRENIER, Christopher R. KNITTEL, Victor MIRANDA, Amanda GAVIN
  • Publication number: 20130315825
    Abstract: Derivatives of phenothiazine, phenoxazine, and phenazine compounds and their use as ?-synuclein ligands are described. Also described are methods of using these compounds and their radiolabeled analogs for the detection, monitoring, and treatment of synucleinopathies, including Parkinson's disease.
    Type: Application
    Filed: May 3, 2013
    Publication date: November 28, 2013
    Applicant: Washington University
    Inventors: Zhude Tu, Robert Mach, Lihai Yu, Paul Kotzbauer
  • Publication number: 20130313532
    Abstract: [Problem] To provide a charge transporting material which allows for a low driving voltage and is superior in luminous efficiency and durability. [Means for resolution] A charge transporting material comprising a compound represented by any one of the following general formula (1-1) to general formula (1-3): wherein R111 to R114, R121 to R125 and R131 to R135 each independently represent a hydrogen atom or a substituent, and may be bound together to form a ring; L111 to L113 each independently represent O or S; L121 to L123 each independently represent a single bond or a divalent linking group; and Ar111 to Ar113 each independently represent an aryl group or a heteroaryl group.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 28, 2013
    Applicant: UDC IRELAND LIMITED
    Inventors: Kousuke WATANABE, Yosuke YAMAMOTO, Wataru SOTOYAMA
  • Publication number: 20130303521
    Abstract: Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
    Type: Application
    Filed: October 26, 2012
    Publication date: November 14, 2013
    Applicant: HYDRA BIOSCIENCES, INC
    Inventor: HYDRA BIOSCIENCES, INC
  • Publication number: 20130289004
    Abstract: A method of treating infection by Staphylococcus in a subject by administering a pharmaceutical composition including a celecoxib derivative of formula I or a pharmaceutically acceptable salt thereof is described. The preparation of numerous celecoxib derivatives for testing as potential anti-staphylococcal agents is also described.
    Type: Application
    Filed: October 31, 2011
    Publication date: October 31, 2013
    Applicant: The Ohio State University Research Foundation
    Inventors: Ching-Shih Chen, Hao-Chieh Chiu, Dasheng Wang, Samuel K. Kulp
  • Publication number: 20130230771
    Abstract: A rechargeable metal ion cell comprising: an anode comprising at least one metal; a charge-carrying electrolyte comprising a charge carrying medium and at least one metal salt; and an organic polymer cathode, wherein such cathode comprises at least one N-substituted polyphenothiazine polymer [polymer (P)], such polymer (P) comprising at least one N-substituted phenothiazine recurring unit of formula: wherein R? is an electron-withdrawing group comprising at least one heteroatom selected from the group consisting of O, S, P, and N.
    Type: Application
    Filed: November 16, 2011
    Publication date: September 5, 2013
    Applicants: UNIVERSITE JOSEPH FOURIER, SOLVAY SA
    Inventors: Alain Deronzier, Thibault Godet-Bar, Jean-Claude Lepretre, Jean-Yves Sanchez
  • Publication number: 20130109681
    Abstract: A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is —CF3, Ar is selected from and R is selected from where R? is L-Lys, D-Lys, ?-Ala, L-Lue, L-Ile, Phe, SO2CH2CH2NH2, SO2NH2, Asn, Glu or Gyl, and R? is methyl, ethyl, allyl, CH2CH2OH, CH2CN, CH2CH2CN, CH2CONH2,
    Type: Application
    Filed: October 7, 2011
    Publication date: May 2, 2013
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Ching-Shih Chen, Hao-Chieh Chiu, Dasheng Wang, John S. Gunn, Larry S. Schlesinger
  • Publication number: 20120302675
    Abstract: A condensed heterocyclic compound which is shown by the following formula (I) and a composition containing an (a) organic material and (b) at least one type of the condensed heterocyclic compound are provided. (Y indicates a chemical single bond, —S(?O)—, or —SO2—. Ra and Rb indicate substitutable C1 to C30 organic groups. Za and Zb indicate chemical single bonds or —SO2—. X1 and X2 indicate hydrogen atoms etc. n and m respectively independently indicate integers of 0 to 2, where one of n and m is not 0).
    Type: Application
    Filed: January 28, 2011
    Publication date: November 29, 2012
    Inventors: Kei Sakamoto, Satoshi Kiriki, Tomonori Ogawa, Masanobu Shinohara
  • Patent number: 8273341
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: September 25, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Michael Graupe, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Evan S. Krygowski, Scott E. Lazerwith, Qi Liu, Richard Mackman, Hyung-Jun Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, Randall W. Vivian, Scott D. Schroeder, William J. Watkins, Lianhong Xu
  • Publication number: 20120238543
    Abstract: Novel compounds, methods, and compositions for treating various viral infections are described. In some embodiments the novel compounds of the invention are 3-oxo-phenothiazine derivatives; more specific embodiments include 3-oxo-phenothiazine derivatives having substituents at the 1-, 7-, and 9-positions of the phenothiazine parent ring. In other embodiments, the invention provides compositions and methods for treating viral infections, especially HIV.
    Type: Application
    Filed: March 16, 2012
    Publication date: September 20, 2012
    Applicant: Prosetta Antiviral, Inc.
    Inventors: Clarence Hurt, Beverly Freeman, Vishwanath Lingappa, Andy Atuegbu, Anatoliy Kitaygorodskyy
  • Publication number: 20120053237
    Abstract: The invention relates to (among other things) oligomer-amino acid conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated amino acid compounds.
    Type: Application
    Filed: February 24, 2010
    Publication date: March 1, 2012
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Xuyuan Gu, Jennifer Riggs-Sauthier
  • Patent number: 8088368
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: January 3, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Scott E. Lazerwith, Richard L. Mackman, Hyung-Jung Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, William J. Watkins, Lianhong Xu
  • Publication number: 20110288292
    Abstract: The present invention relates to substituted benzo[c]phenanthrene derivatives and to the production and to the use thereof in electronic devices, and to the electronic devices themselves. The present invention relates in particular to benzo[c]phenanthrene derivatives substituted with at least one aromatic unit or at least one diarylamino unit.
    Type: Application
    Filed: December 22, 2009
    Publication date: November 24, 2011
    Applicant: Merck Patent GmbH
    Inventors: Amir H. Parham, Arne Buesing, Holger Heil, Philipp Stoessel
  • Patent number: 8022204
    Abstract: A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: September 20, 2011
    Assignee: Bayer Healthcare LLC
    Inventors: Karen L. Marfurt, Henry C. Arndt
  • Publication number: 20110212173
    Abstract: There is described a pharmaceutical composition for controlled release of an active compound wherein the active compound is selected from the group comprising tramadol, resveratrol, acetaminophen, xorphanol, cinfenoac, furcloprofen, bismuth subsalicylate, enofelast, triflusal, ketorfanol, indriline, furofenac, cizolirtine, dacemazine, demelverine, and fenethazine, and derivatives and/or combinations thereof for the treatment or alleviation of depression. More particularly, there is described an abuse resistant pharmaceutical composition for the treatment of inter alia, depression and controlled release pharmaceutical compositions of related thereto.
    Type: Application
    Filed: June 17, 2009
    Publication date: September 1, 2011
    Applicant: e-Therapeutics Ple
    Inventors: Malcolm Philip Young, Olusola Clement Idowu, Philip McKeown
  • Patent number: 8008037
    Abstract: A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: August 30, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christopher D. Wilsey, Mitali Ghoshal, Herbert Wieder
  • Publication number: 20110177007
    Abstract: The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include dyes, and derivatives thereof, having a fused ring backbone structure having dithienopyrrole core. In some embodiments, dyes of the present invention are dithienopyrrole dyes having a dithienopyrrole core optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties.
    Type: Application
    Filed: September 29, 2009
    Publication date: July 21, 2011
    Inventors: Raghavan Rajagopalan, William L. Neumann, Amruta Poreddy, John N. Freskos, Richard B. Dorshow
  • Publication number: 20110177006
    Abstract: The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include dyes, and derivatives thereof, having a fused ring backbone structure having dithienofuran core. In some embodiments, dyes of the present invention are dithienofuran dyes having a dithienofuran core optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties.
    Type: Application
    Filed: September 29, 2009
    Publication date: July 21, 2011
    Inventors: Raghavan Rajagopalan, William L. Neumann, Amruta Poreddy, John N. Freskos, Richard B. Dorshow
  • Publication number: 20110152246
    Abstract: The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 23, 2011
    Applicant: InterMune, Inc.
    Inventors: Brad Buckman, John B. Nicholas, Vladimir Serebryany, Scott D. Seiwert
  • Publication number: 20110118199
    Abstract: The present invention relates to the treatment of protozoal diseases by administering cytotoxic and/or cytostatic compounds, in particular those used in anticancer therapy, to patients. In particular, the invention relates to the use of anticancer agents that can penetrate into the CNS for treatment of late stage African sleeping sickness or cerebral malaria.
    Type: Application
    Filed: January 11, 2007
    Publication date: May 19, 2011
    Inventor: Matthias Dormeyer
  • Patent number: 7902197
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: March 8, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Todd Richard Elworthy, Robert Than Hendricks, Rama K. Kondru, Yan Lou, Timothy D. Owens, Michael Soth, Hanbiao Yang
  • Publication number: 20110028716
    Abstract: The present invention relates to a dye for a dye-sensitised solar cell. The dye according to the present invention has a high degree of light absorbency and can improve the photoelectric current conversion efficiency when employed in a light-absorbing layer for a solar cell.
    Type: Application
    Filed: February 5, 2009
    Publication date: February 3, 2011
    Applicant: SOLARSYS CO., LTD.
    Inventors: Kwang-Yol Kay, Kang-Jin Kim, Jong-Hyung Kim, Young-Jin Kwon
  • Patent number: 7879995
    Abstract: An organic electroluminescent device, which has, between a pair of electrodes, at least one organic layer including a light-emitting layer, in which the organic layer contains a specific tetraphenylene compound, and in which the light-emitting layer contains a phosphorescent material; and a specific tetraphenylene compound that can be used in the device.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: February 1, 2011
    Assignee: Fujfilm Corporation
    Inventors: Jun Ogasawara, Tatsuya Igarashi, Satoshi Sano
  • Publication number: 20110009523
    Abstract: A polymerisable ethylenically unsaturated macromonomer being the reaction product of: i) an adduct formed from the reaction of an unsaturated non-mineral oil reacted with an enophile having an acid, ester or anhydride moiety and ii) an ethylenically unsaturated monomer having a moiety reactive with the acid, ester or anhydride moiety of the enophile and iii) a chain extender material having at least two moieties reactive with the acid, ester or anhydride moiety of the enophile.
    Type: Application
    Filed: December 16, 2008
    Publication date: January 13, 2011
    Inventors: Neal Willams, Chris Lampard
  • Publication number: 20100331540
    Abstract: A method for producing a compound having a deuterated aromatic ring or heterocyclic ring according to the invention includes heating a compound having an aromatic ring or heterocyclic ring in the presence of heavy water, a transition metal and a metal which generates deuterium. As the metal which generates deuterium, at least one metal selected from the group consisting of aluminum, magnesium, zinc, iron, lead and tin is preferred. As the transition metal, at least one metal selected from the group consisting of platinum, palladium, ruthenium and rhodium is preferred. The heating is preferably carried out by microwave irradiation.
    Type: Application
    Filed: January 30, 2009
    Publication date: December 30, 2010
    Inventors: Haruki Shimodaira, Toshifumi Abe, Akira Miyazawa, Yuji Kawanishi, Taichi Abe
  • Patent number: 7855287
    Abstract: A process is described for preparing, efficiently and with a high degree of purity N-alkylsulfonates of phenothiazine. The process consists in (a) the preparation of the phenothiazine anion, and (b) the reaction of said anion with cyclic alkyl sulfonates, such as 1,3-propane sultone and 1,4-butane sultone. This process is simpler, more direct, and more efficient than the procedures currently used for the synthesis of N-alkylsulfonates derivatives of phenothiazine. In addition, the products obtained with this process are far more pure than those obtained through current procedures and therefore ideal for bioanalytical applications that require high sensitivity, such as assays based on the measurement of peroxidase activity using chemiluminescence.
    Type: Grant
    Filed: January 23, 2008
    Date of Patent: December 21, 2010
    Assignee: Cyanagen Srl
    Inventor: Leopoldo Della Ciana
  • Publication number: 20100308714
    Abstract: The use of phenoxazine, phenothiazine, phenothiazine S-oxide or phenothiazine S,S-dioxide derivatives as emitter substances in organic light-emitting diodes, an organic light-emitting diode comprising a light-emitting layer, the light-emitting layer comprising at least one phenoxazine, phenothiazine, phenothiazine S-oxide or phenothiazine S,S-dioxide derivative as an emitter substance, and a light-emitting layer comprising or consisting of the aforementioned phenoxazine, phenothiazine-phenothiazine, phenothiazine S-oxide or phenothiazine S,S-dioxide derivative as an emitter substance, a hole- and exciton-blocking layer comprising or consisting of the aforementioned phenoxazine derivative, phenothiazine derivative, phenothiazine S-oxide derivative or phenothiazine S,S-dioxide derivative, and a device which comprises an inventive organic light-emitting diode.
    Type: Application
    Filed: November 25, 2005
    Publication date: December 9, 2010
    Applicant: BASF Aktiengesellschaft
    Inventors: Thomas Gessner, Hans-Werner Schmidt, Mukundan Thelakkat, Markus Baete
  • Publication number: 20100310512
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: May 12, 2010
    Publication date: December 9, 2010
    Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Michael Graupe, Evan S. Krygowski, Scott E. Lazerwith, Qi Liu, Richard L. Mackman, Hyung-Jun Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, Randall W. Vivian, Scott D. Schroeder, William J. Watkins, Lianhong Xu
  • Patent number: 7833635
    Abstract: A cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, color stability, and thermal stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, an emitting layer, in an organoelectroluminescent device, and as an organic dye or an electronic material such as a nonlinear optical material.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: November 16, 2010
    Assignee: Samsung Mobile Display Co., Ltd.
    Inventors: Sang-Hoon Park, Yu-Jin Kim, O-Hyun Kwon, Byoung-Ki Choi, Jhun-Mo Son
  • Publication number: 20100261643
    Abstract: The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.
    Type: Application
    Filed: March 16, 2010
    Publication date: October 14, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Stefanie KEIL, Elisabeth DEFOSSA, Dieter SCHMOLL, Axel DIETRICH, Johanna KUHLMANN-GOTTKE, Karl-Christian ENGEL
  • Publication number: 20100254910
    Abstract: The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.
    Type: Application
    Filed: June 11, 2010
    Publication date: October 7, 2010
    Applicant: Vanderbilt University
    Inventors: Lawrence J. Marnett, Md. Jashim Uddin, Brenda C. Crews
  • Patent number: 7790881
    Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: September 7, 2010
    Assignee: Wista Laboratories Ltd.
    Inventors: John Mervyn David Storey, James Peter Sinclair, Colin Marshall, Han Wan Tan