Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(dimethylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.

Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(di-methylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.

Abstract: A process for the preparation of diaminophenothiazinium compounds is described, which allows achieving quickly and effectively a high degree of purity of the same.

Abstract: Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue) are provided.

Abstract: A process for the purification of diaminophenothiazinium compounds, and particularly of methylene blue, is described. The process provides for simple and effective purification by reduction of the post-synthesis or commercially available diaminophenothiazinium compound to form a reduced complex thereof. This can then be purified in a more straightforward manner than the original compound by, for example, recrystallization before being allowed to oxidize back to the diaminophenothiazinium compound.

Abstract: Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue) are provided.

Abstract: Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue) are provided.

Abstract: A process for the purification of diaminophenothiazinium compounds, and particularly of methylene blue, is described. The process provides for simple and affective purification by reduction of the post-synthesis or commercially available diaminophenothiazinium compound to form a reduced complex thereof. This can then be purified in a more straightforward manner than the original compound by, for example, recrystallization before being allowed to oxidize back to the diaminophenothiazinium compound.

Abstract: Process for preparing compounds of the diaminophenothiazinium type of formula (II) below. The products have a high degree of purity and are useful for the preparation of medicaments. In which the R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 groups having the same definition as in formula (I), and R representing a group chosen from: a phenyl or benzyl group, optionally substituted with one or more functions chosen from: a C1-C4 alkyl, a halogen atom, a C1-C4 haloalkyl and a nitro group, a linear, branched or cyclic C1-C8 alkyl group, a C1-C8 alkylamino group, a C1-C8 alkoxy group, a phenyloxy or benzyloxy group optionally substituted on the aromatic nucleus with one or more functions chosen from: a C1-C4 alkyl, a halogen atom, a C1-C4 haloalkyl and a nitro group, Z representing an atom chosen from O and S.

Abstract: Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209° C.). Also disclosed are a process of preparing perphenazine 4-aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.

Abstract: A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.

Abstract: Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209° C.). Also disclosed are a process of preparing perphenazine 4-aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.

Abstract: Described are compositions and methods of making high purity diaminophenothiazinium compounds of the following formula which are characterised by: a purity of greater than 98%; less than 1% Azure B as impurity; less than 0.15% Azure A as impurity; less than 0.15% Azure C as impurity; and less than 0.05% Methylene Violet Bernthsen (MVB) as impurity. Examples include methylthioninium chloride (MTC), also known as Methylene Blue (MB).

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.

Abstract: A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.

Abstract: Photochemical demethylation reactions in solutions of thiazine dyes, in which the dye molecules act as both sensitizer and substrate, are reduced by quenching triple-state dye molecules, returning them to the unreactive ground state.

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.

Abstract: Methods for the preparation of 7-(dipropylamino)pheno-thiazin-3-ylidene]-dipropylamine.

Abstract: A process for producing a phenothiazinium compound comprising the step of: reacting phenothiazine, in the presence of a halogen, with at least one amine selected from the group consisting of: wherein Z is CH2, O, S, SO2, NH, NCH3, NC2H5, NCH2CH2OH or NCOCH3, and R1 and R2 are each independently linear or branched CnH2nY.

Abstract: This invention relates to a novel, technically advantageous process for the preparation of a mixture of alkylated phenothiazines and diphenylamines. Starting from diphenylamine, this is reacted with elemental sulfur in the presence of iodine, and the substance mixture of diphenylamine and phenothiazine is treated with an olefin in the presence of an acid catalyst.

Abstract: The present invention relates to novel spherical agglomerates of 10-phenothiazinylpropanoic acid. The invention also relates to a process for obtaining those agglomerates.The process for preparing the spherical agglomerates of 10-phenothiazinylpropanoic acid is characterized by stirring a suspension of 10-phenothiazinylpropanoic acid in water in the presence of a binder liquid which is not miscible with water selected from esters of aliphatic or cycloaliphatic acids, aliphatic or cycloaliphatic alcohols, and aliphatic or cycloaliphatic ketones.

Abstract: Compounds of formula (I), where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have defined meanings ##STR1## are useful as surfactants especially in agrochemical formulations, pigment dispersions and domestic detergent formulations. Compounds where one of R.sup.1 and R.sup.2 is hydrogen and the other is C.sub.8 to C.sub.18 straight chain alkenyl group, the group --NR.sup.3 R.sup.4 is the residue of a glycamine, especially a glucamine, and R.sup.5 is --NR.sup.3 R.sup.4 as defined (especially a glycamine residue) or a group O.(AO).sub.n.R.sup.6 where AO is an alkylene oxide, especially an ethylene oxide, residue, n is especially from 3 to 50 and R.sup.6 is a C.sub.1 to C.sub.6 alkyl group, are particularly desirable.

Abstract: Method of preparation of 6-fluoro-2-halogen quinoline of general formula (I) wherein R is a hydrogen atom or an alkyl radical and Hal and Hal' are identical or different halogen atoms. The invention is characterized in that a halogenating agent is made to act on hydroxy-1 quinoline of general formula (II) wherein Hal is defined as above and R.sub.1 is defined as R excepting a hydrogen atom, the acid function being optionally released if a 6-fluoro-2-halogen quinoline is to be obtained for which R is a hydrogen atom.

Abstract: A mixture containing phenothiazines which is obtainable by reacting a mixture of diphenylamines comprising______________________________________ 1 to 5% by weight of a) diphenylamine 8 to 18% by weight of b) 4-tert-butyldiphenylamine 21 to 31% by weight of c) one or more compounds selected from i) 4-tert-octyldiphenylamine ii) 4,4'-di-tert-butyldiphenylamine iii) 2,4,4'-tris-tert-butyldiphenylamine 20 to 31% by weight of d) one or more compounds selected from i) 4-tert-butyl-4'-tert-octyldiphenylamine ii) 2,2'- or 2,4'-di-tert- octyldiphenylamine iii) 2,4-di-tert-butyl-4'-tert- octyldiphenylamine, and 15 to 29% by weight of e) the compound i) 4,4'-di-tert-octyldiphenylamine, or the compounds i) 4,4'-di-tert-octyldiphenylamine and ii) 2,4-di-tert-octyl-4'-tert- butyldiphenylamine, ______________________________________with 1 to 200 mol % of elemental sulfur, in the presence of 0.

Abstract: An ammonium salt of an alkenylsuccinic half-amide of formula (I) below ##STR1## in which R.sup.1 denotes H or a C.sub.6 -C.sub.18 -alkenyl radical, provided that the radicals R.sup.1 are not both H or both C.sub.6 -C.sub.18 -alkenyl,X denotes a group of the formula --NHR.sup.2 or --NR.sup.2 R.sup.3, in whichR.sup.2 and R.sup.3 denote C.sub.1 -C.sub.6 -alkyl, cycloalkyl or a heterocyclic ring attached to the nitrogen atom via an alkylene chain,andA denotes XH or a different primary, secondary, or tertiary amine, for example an alkanolamine or a polyamine,and the use thereof as a corrosion inhibitor in oil and/or gas production technology.

Abstract: A process for the direct and regioselective functionalization of phenothiazine which allows to introduce an SH group in position 2 by reaction with sulfur dioxide (SO.sub.2) and aluminum trichloride (AlCl.sub.3) with subsequent reduction is described.The thus obtained 2-mercapto-phenothiazine is easy transformed into 2-methylthio-phenothiazine, an important intermediate for the preparation of pharmacological active compounds.

Abstract: The present invention provides a process for inversion of the absolute stereochemistry at the .alpha.-carbon atom of a C-6 substituent of a bicyclic carbapenem antibiotic via a phosphorus - azodicarboxylate mediated reaction. Novel azides, amines and formates are described as useful intermediates and as antibacterial agents.

Abstract: New sulphur dyestuffs are prepared by reacting sulphur with a 4-hydroxydiphenylamine of the formula ##STR1## wherein R and R.sup.1 denote hydrogen or alkyl having 1 to 4 carbon atoms and the nucleus A has at least one free ortho-position in relation to the imino group, in a first stage at an elevated temperature to form a thiazine compound which is then sulphurized in a second stage in a water-soluble solvent at an elevated temperature to produce the sulphur dyestuff, and wherein a molar ratio of first stage reactants of 1:(2 to 2.4) between the 4-hydroxydiphenylamine compound and sulphur is maintained.