Chalcogen Or Halogen Containing Substituent Patents (Class 544/215)
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Patent number: 5962683Abstract: A description is given of compounds of the formula I ##STR1## where r is 0 or 1 and y is a number from the range 1-3; X is a direct bond or --NR.sub.8 --, --CO--, --CONH-- or --COO-- or a divalent aliphatic or mixed aromatic-aliphatic C.sub.1 -C.sub.18 hydrocarbon radical;Z is an aromatic, aliphatic or mixed aromatic-aliphatic C.sub.3 -C.sub.18 hydrocarbon radical which is interrupted in the aliphatic moiety by one or more divalent functional groups, in each case in a carbon-carbon single bond, and/or in the aromatic or aliphatic moiety by one or more divalent functional groups, in each case in a carbon-hydrogen bond, possible functional groups being --O--, --NR.sub.8 --, --S--, --SO--, --SO.sub.Type: GrantFiled: June 17, 1997Date of Patent: October 5, 1999Assignee: Ciba Specialty Chemicals Corp.Inventors: Alfred Steinmann, Rolf Mulhaupt
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Patent number: 5962452Abstract: Resorcinyl-triazines of formula ##STR1## are described. The compounds according to the invention are suitable especially as sunscreens in cosmetic, pharmaceutical and veterinary compositions.Type: GrantFiled: May 14, 1998Date of Patent: October 5, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Jurg Haase, Helmet Luther
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Patent number: 5959106Abstract: N-(substituted aryl)?1,2,4!triazoloazinesulfonamide compounds, such as N-(2,6-difluorophenyl)-8-fluoro-5-methoxy?1,2,4!triazolo?1,5-c!pyrimidine- 2-sulfonamide, were prepared at a good reaction rate and in good yield by the reaction of a chlorosulfonyl?1,2,4!triazoloazine compound, such as 2-chlorosulfonyl-8-fluoro-5-methoxy?1,2,4!triazolo?1,5-c!pyrimidine, and an arylamine compound, such as 2,6-difluoroaniline, in an organic medium containing a relatively acidic alcohol, such as propylene glycol or 2,2,2-trifluoroethanol.Type: GrantFiled: January 25, 1999Date of Patent: September 28, 1999Assignee: Dow AgroSciences LLCInventors: Douglas L. Pearson, Timothy J. Adaway
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Patent number: 5945396Abstract: The present invention provides a compound having the formula: ##STR1## in which each R.sub.d is the same or different and each is --NH--Z--N(R.sub.a)(R.sub.b) or --N--?Z--N(R.sub.a)(R.sub.b)!.sub.2 in which Z is C.sub.2 -C.sub.14 alkylene or optionally substituted arylene, R.sub.a and R.sub.b are the same or different and each is C.sub.1 -C.sub.12 alkyl, or R.sub.a and R.sub.b, together with the nitrogen atom to which they are each attached, form a morpholino, piperidino or piperazino ring; each R.sub.c is the same or different and is NH.sub.2, NH(C.sub.1 -C.sub.4 alkyl), N(C.sub.1 -C.sub.4 alkyl).sub.2, N(CH.sub.2 CH.sub.2 OH).sub.2, O--C.sub.1 -C.sub.4 alkyl, ##STR2## alkali metal atom, ammonium or a cation formed from an amine; or a quaternized form thereof.Type: GrantFiled: December 23, 1997Date of Patent: August 31, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Claude Eckhardt, Georges Metzger, Dieter Reinehr, Hanspeter Sauter, Mario Dubini
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Patent number: 5892032Abstract: A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: ##STR1## in which each A.sup.n is nitrogen or CR.sup.n (n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two nitrogen atoms are not bonded directly to one another; R.sup.1 to R.sup.5, if present, independently of one another are hydrogen, C.sub.1-4 -alkyl or aryl, one of the substituents R.sup.1 to R.sup.5 being a group of the formula --OR, in which R is an optionally substituted aromatic or heteroaromatic radical; R.sup.6 is hydrogen or C.sub.1-4 -alkyl; and R.sup.7 is an optionally substituted aromatic or heteroaromatic radical. The amides are obtained from the corresponding heteroaromatic halogen compounds, the corresponding aromatic amines and carbon monoxide in the presence of a palladium phosphine complex. Compounds of this class are important herbicides.Type: GrantFiled: May 2, 1997Date of Patent: April 6, 1999Assignee: Lonza AGInventors: Jean-Paul Roduit, Georges Kalbermatten
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Patent number: 5889006Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula with acetylcholinesterase inhibitors.Type: GrantFiled: August 8, 1996Date of Patent: March 30, 1999Assignee: Schering CorporationInventors: Derek B. Lowe, Wei K. Chang, Joseph A. Kozlowski, Joel G. Berger, Robert McQuade, Allen Barnett, Margaret Sherlock, Wing Tom, Sundeep Dugar, Lian-Yong Chen, John W. Clader, Samuel Chackalamannil, Yuguang Wang, Stuart W. McCombie, Jayaram R. Tagat, Susan F. Vice, Wayne Vaccaro, Michael J. Green, Margaret E. Browne, Theodros Asberom, Craig D. Boyle
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Patent number: 5886176Abstract: The invention relates to a novel process for preparing herbicidal sulphonylurea salts of the formula (I) ##STR1## in which M.sup.+ represents an alkali metal ion or an alkaline earth metal ion equivalent,Z represents N, CH or C-halogen,R.sup.1 represents in each case optionally substituted aryl, aralkyl or heteroaryl,(where R.sup.2, X and Y have the meanings given in the description).Type: GrantFiled: March 1, 1993Date of Patent: March 23, 1999Assignee: Bayer AktiengesellschaftInventor: Klaus-Helmut Muller
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Patent number: 5883096Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds of formula I ##STR1## wherein one of Y and Z is N and the other is N, CH, or C-alkyl;X is --O--, --SO.sub.0-2 --, amino, substituted amino, --CO--, --CH.sub.2 --, mono or di-substituted methylene, --CS--, --CONR.sup.20 --, --NR.sup.20 --SO.sub.2 --, --NR.sup.20 CO--, --SO.sub.2 NR.sup.20 --, --CH.dbd.CH--, --C.tbd.C-- or --NHC(O)NH--;R is optionally substituted phenyl, aryl or cycloalkyl, or other substituents as defined in the specification;R.sup.1 and R.sup.21 are H, CN or optionally substituted alkyl, or other substituents as defined in the specification;R.sup.2 is optionally substituted cycloalkyl or piperidyl, or other substituents as defined in the specification; andR.sup.3, R.sup.4, R.sup.5, R.sup.20, R.sup.27 and R.sup.Type: GrantFiled: February 16, 1996Date of Patent: March 16, 1999Assignee: Schering CorporationInventors: Derek Lowe, Wei Chang, Joseph Kozlowski, Joel G. Berger, Robert McQuade, Allen Barnett, Margaret Sherlock, Wing Tom, Sundeep Dugar, Lian-Yong Chen, John W. Clader, Samuel Chackalamannil, Wang Yuguang, Stuart W. McCombie, Jayaram R. Tagat, Susan F. Vice, Wayne Vaccaro, Michael J. Green, Margaret E. Browne, Theodros Asberom
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Patent number: 5830243Abstract: The present invention is directed to a composition made by reacting A) an aldehyde of 1 to 12 carbon atoms or a reactive equivalent thereof; and B) at least one etheramine represented by the formulaR.sup.2 ?O(CH.sub.2 CH(R)O).sub.n --R.sup.1 --NH.sub.2 !.sub.y(I)wherein each n is a number from 0 to about 50; each R is selected from the group consisting of hydrogen, hydrocarbyl groups of 1 to about 16 carbon atoms, and mixtures thereof; each R.sup.1 is selected from the group consisting of a hydrocarbylene group containing 2 to about 18 carbon atoms and a group represented by the formula ##STR1## wherein both R.sup.6 and R.sup.7 are hydrocarbylene groups of about 3 to about 10 carbon atoms and p is a number from 1 to 4; y is 1, 2, or 3; and each R.sup.2 is a hydrocarbyl group having a valence of y and containing 1 to about 50 carbon atoms when y is 1 and 1 to about 18 carbon atoms when y is 2 or 3; y is 1, 2, or 3; provided that when n is zero, y is 1.Type: GrantFiled: September 11, 1997Date of Patent: November 3, 1998Assignee: The Lubrizol CorporationInventors: Thomas J. Wolak, Daniel T. Daly, Kurt F. Wollenberg, William D. Abraham, Paul E. Adams, Mitchell M. Jackson
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Patent number: 5824677Abstract: Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocyle. R.sub.3 may be either hydrogen or C.sub.13. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.Type: GrantFiled: June 7, 1995Date of Patent: October 20, 1998Assignee: Cell Therapeutics, Inc.Inventors: J. Peter Klein, Gail E. Underiner, Anil M. Kumar
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Patent number: 5814633Abstract: Iminooxymephyleneanilides of the formula I ##STR1## where the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4;R is nitro, cyano, halogen, unsubst. or subst. alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy or an unsubst. or subst. bridge bonded to two adjacent ring atoms;X is a direct bond or CH.sub.2, O or NR.sup.a ;R.sup.a is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl;R.sup.1 is hydrogen,unsubst. or subst. alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkylcarbonyl or alkoxycarbonyl;R.sup.2 is alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, or in the case where X is NR.sup.a, additionally hydrogen;R.sup.3 is hydrogen, cyano, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio or cycloalkyl;R.sup.4 is a 6- to 10-membered mono- or bicyclic, substituted heteroaromatic ring system,and process and intermediates for their preparation and their use.Type: GrantFiled: May 20, 1997Date of Patent: September 29, 1998Assignee: BASF AktiengesellschaftInventors: Bernd Muller, Hubert Sauter, Franz Rohl, Eberhard Ammermann, Gisela Lorenz, Norbert Gotz
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Patent number: 5804583Abstract: Derivatives of bicyclic heterocycles comprising a pyrimidone ring fused to another 5, 6, or 7 membered nitrogen heterocycle which is C-substituted, through a methylene bridge, by a biphenyl group.Type: GrantFiled: December 18, 1996Date of Patent: September 8, 1998Assignee: Istituto Luso Farmaco D'ItaliaInventors: Aldo Salimbeni, Davide Poma, Anna Renzetti, Carlo Scolastico
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Patent number: 5786477Abstract: Polymers are stabilized against degradation by the addition of a liquid composition comprising an organic solvent and at least 40% by weight of a triaryl triazine of the formula (I): ##STR1## wherein X, Y, and Z are each the same or different aromatic carbocyclic radicals, and at least one of X, Y, and Z is substituted by a hydroxy group ortho to the point of attachment to the triazine ring, and at least one of R1 to R9 is an alkoxy radical of the formula, --O--(mixed alkyl) substituted at a point para to the point of attachment to the triazine ring, and the remainder of R1 to R9 are selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, sulfonic, carboxy, halo, haloalkyl, and acylamino; with the proviso that --O--(mixed alkyl) is an alkoxy radical formed from an mixture of isomeric C.sub.6 to C.sub.12 alkyl halides containing at least 10% each of at least three different isomers.Type: GrantFiled: May 31, 1995Date of Patent: July 28, 1998Assignee: Cytec Technology Corp.Inventor: Paul Sheldon Waterman
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Patent number: 5741905Abstract: New compounds having the formula ##STR1## in which m is 1 or 2; when m is 1, A is a residue selected from those of the formulae ##STR2## and, when m is 2, A is a residue of the formula ##STR3## B is --O--, --NH-- or --SO.sub.2 --, and D is as defined herein, are useful as ultraviolet absorbing agents (UVAs) and a method of improving the sun protection factor of textile fibre material by treating the material with the new compounds.Type: GrantFiled: June 6, 1995Date of Patent: April 21, 1998Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Pierre Bacher, Werner Kaufmann, Dieter Reinehr
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Patent number: 5723411Abstract: Compounds of Formula I, and their N-oxides and agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein Q, W, R.sup.1, R.sup.2 and R.sup.3 are as defined in the disclosure.Also disclosed are compositions containing the compounds of Formula I and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective mount of a compound of Formula I.Type: GrantFiled: October 16, 1996Date of Patent: March 3, 1998Assignee: E. I. du Pont de Nemours and CompanyInventor: Thomas Martin Stevenson
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Patent number: 5714637Abstract: Fluoropolyethers having functional groups, consisting of randomly distributed sequences of perfluoropolyoxyalkylene units selected from: ##STR1## and included in one of the following formulas: ##STR2##T'--O--(CF.sub.2 CF.sub.2 O).sub.p (CF.sub.2 O).sub.s --CRR'--Y(II) ##STR3## where X is F or CF.sub.3 T, T', T"=a perfluoroalkyl group containing from 1 to 3 carbon atoms and one or two atoms of Cl, Br or I;R, R'=halogen atoms;Y=a functional group;o, q=numbers, zero included, such that o+q=1-20;n=a number ranging from 1 to 15;m/n=a number ranging from 0.01 to 0.5;p=a number ranging from 1 to 20;s/p=a number ranging from 0.5 to 2; andz/o+p=a number ranging from 0.01 to 0.05.Type: GrantFiled: June 2, 1995Date of Patent: February 3, 1998Assignee: Ausimont S.R.L.Inventors: Giuseppe Marchionni, Piero Gavezotti, Ezio Strepparola
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Patent number: 5705643Abstract: Novel dihydrotriazine compounds corresponding to formula (2') ##STR1## wherein R'.sub.1, R'.sub.2 and R'.sub.3 are each independently of one another hydrogen, halogen, C.sub.1 -C.sub.18 alkyl, C.sub.1 -C.sub.18 alkoxy or --C.tbd.N, with the proviso that R'.sub.1, R.sub.'2 and R'.sub.3 are not simultaneously hydrogen. The above dihydrotriazines are useful as starting compounds for the preparation of UV absorbers.Type: GrantFiled: September 25, 1995Date of Patent: January 6, 1998Assignee: Ciba Specialty Chemicals CorporationInventors: Dieter Reinehr, Jean Pierre Bacher
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Patent number: 5696154Abstract: Provided are brefeldin A derivatives of the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 is H and the other of R.sub.1 and R.sub.2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A.Type: GrantFiled: June 29, 1994Date of Patent: December 9, 1997Assignees: The United States of America as represented by the Department of Health and Human Services, Starks Associates, Inc.Inventors: Louis Malspeis, B. Rao Vishnuvajjala, Jeffrey G. Supko, Charles Theodore Kane, Jr.
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Patent number: 5684070Abstract: Tris-aryl-s-triazines of formula VI ##STR1## which contain from one to three resorcinol derived moieties have UV spectra which are red-shifted to the near UV range and provide excellent stabilization to polymeric substrates against the deleterious effects of actinic light.Type: GrantFiled: July 15, 1996Date of Patent: November 4, 1997Assignee: Ciba Specialty Chemicals CorporationInventor: Tyler Arthur Stevenson
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Patent number: 5681955Abstract: Tris-aryl-s-triazines of formula VI ##STR1## which contain one or more resorcinol derived moieties have UV spectra which are red-shifted to the near UV range and provide excellent stabilization to polymeric substrates against the deleterious effects of actinic light.Type: GrantFiled: July 15, 1996Date of Patent: October 28, 1997Assignee: Ciba Specialty Chemicals CorporationInventor: Tyler Arthur Stevenson
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Patent number: 5677450Abstract: Disclosed are an organic acid salt of melamine represented by the following general formula (1) and a thermosetting and a photocurable and thermosetting coating compositions containing the salt mentioned above. ##STR1## wherein Z represents ##STR2## wherein R.sup.1 represents a hydrogen atom or an alkyl group, alkylene group, alicyclic hydrocarbon, or aromatic hydrocarbon severally having from 1 to 18 carbon atoms, or any of said groups or hydrocarbons whose hydrogen atom is substituted by carboxyl group, hydroxyl group, or a halogen atom, R.sup.2 represents a hydrogen atom or an alkyl group or alkylene group severally having from 1 to 9 carbon atoms, or any of said groups whose hydrogen atom is substituted by acryloyl group or methacryloyl group, R.sup.3 represents an alkyl group or alkylene group severally having from 1 to 9 carbon atoms, or any of said groups whose hydrogen atom is substituted by acryloyl group or methacryloyl group, and R.sup.Type: GrantFiled: November 5, 1996Date of Patent: October 14, 1997Assignee: Taiyo Ink Manufacturing Co., Ltd.Inventors: Nobuyuki Suzuki, Kazunobu Fukushima, Kyo Ichikawa, Teruo Saito, Hitoshi Inagaki
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Patent number: 5675004Abstract: Tris-aryl-s-triazines of formula V ##STR1## which contain from one one to three resorcinol derived moieties with at least one of said moieties substituted in the 5-position with a group such as, for example, alkyl or phenylalkyl have UV spectra which are red-shifted to the near UV range and provide excellent stabilization to polymeric substrates against the deleterious effects of actinic light.Type: GrantFiled: June 2, 1995Date of Patent: October 7, 1997Assignee: Ciba-Geigy CorporationInventor: Tyler Arthur Stevenson
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Patent number: 5674894Abstract: The current invention discloses novel amidine derivatives with nitric oxide donating property that can inhibit platelet aggregation and promote vasodilation in a single compound.Type: GrantFiled: May 15, 1995Date of Patent: October 7, 1997Assignee: G.D. Searle & Co.Inventors: Mark G. Currie, Foe S. Tjoeng, Mark E. Zupec
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Patent number: 5674811Abstract: A cyanoketone derivatives of the following formula (1) ##STR1## which are characterized by excellent herbicidal activity and effectiveness against a variety of broad leafed weeds, including barnyard grass, green foxtail, velvet leaf, livid amaranth and hairy beggar ticks.Type: GrantFiled: October 6, 1994Date of Patent: October 7, 1997Assignee: Tokuyama CorporationInventors: Toshio Kitajima, Tadashi Kobutani, Shozo Kato, Masao Yamaguchi, Masahiko Ishizaki, deceased
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Patent number: 5672704Abstract: s-Triazine UV absorbers of formula I ##STR1## where R.sub.1 is ##STR2## --CH.sub.2 --C(.dbd.CH.sub.2)--R.sub.10, --(CH.sub.2).sub.p --SiR.sub.11 R.sub.11 '--CH.dbd.CH.sub.2, --C(.dbd.O)--(CH.sub.2).sub.q --CH.dbd.CH.sub.2 or --C(.dbd.O)--O--CH.sub.2 --C(.dbd.CH.sub.2)--R.sub.10 ; and E.sub.1 and E.sub.2 are phenyl groups which may be unsubstituted or substituted with a variety of substituents including inter alia alkyl, OH and R.sub.1 ; are polymerizable and are effective stabilizers for a variety of polymeric and other organic substrates.Type: GrantFiled: September 28, 1995Date of Patent: September 30, 1997Assignee: Ciba-Geigy CorporationInventors: Vien Van Toan, David George Leppard, Gerhard Rytz, Norbert Wurms, Pascal Hayoz
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Patent number: 5670613Abstract: N-Vinyl-containing glycoluril derivatives I ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.8 -cycloalkyl, phenyl, tolyl or C.sub.7 -C.sub.12 -phenylalkyl orR.sup.1 and R.sup.2 together form a tri-, tetra- or pentamethylene group,R.sup.3 to R.sup.6 are each C.sub.1 -C.sub.4 -alkyl,R.sup.7 is hydrogen, C.sub.1 -C.sub.8 -alkyl, cyano or a radical of the formula COOR.sup.9,R.sup.8 is cyano or a radical of the formula COOR.sup.9 andR.sup.9 is C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.8 -cycloalkyl, phenyl, tolyl or C.sub.7 -C.sub.12 -phenylalkyl,are suitable as light stabilizers and stabilizers for organic material, in particular for plastics and coatings.Type: GrantFiled: August 7, 1995Date of Patent: September 23, 1997Assignee: BASF AktiengesellschaftInventors: Alfred Krause, Alexander Aumueller, Eckhard Korona, Hubert Trauth
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Patent number: 5665885Abstract: Esters or phenol ethers of the formula I or II ##STR1## in which m and n are each an integer from the range from 1 to 6; A.sup.1 is an m-valent hydrocarbon radical having 1 to 30 carbon atoms; or an m-valent hydrocarbon radical having 2 to 30 carbon atoms, which contains the heteroatoms oxygen, nitrogen and/or sulfur and the free valencies of which are located on carbon atoms and in which A.sup.1, in the case where m=2, additionally is a direct bond;A.sup.2 is an n-valent aromatic or araliphatic hydrocarbon radical having 6 to 30 carbon atoms; or an n-valent aromatic or araliphatic hydrocarbon radical having 5 to 30 carbon atoms, which contains the heteroatoms oxygen, nitrogen and/or sulfur and n free valencies of which are located on those carbon atoms which are a constituent of aromatic rings;R.sup.1 is hydrogen; a hydrocarbon or hydrocarbonoxy radical having 1 to 36 carbon atoms, which is unsubstituted or substituted by --CO--N(R.sup.3).sub.2 or interrupted by --CO--N(R.sup.3)-- or --N(R.sup.Type: GrantFiled: June 7, 1995Date of Patent: September 9, 1997Assignee: Ciba-Geigy CorporationInventor: Alfred Steinmann
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Patent number: 5648488Abstract: Tris-aryl-s-triazines of formula V ##STR1## which contain from one one to three resorcinol derived moieties with at least one of said moieties substituted in the 5-position with a group such as, for example, alkyl or phenylalkyl have UV spectra which are red-shifted to the near UV range and provide excellent stabilization to polymeric substrates against the deleterious effects of actinic light.Type: GrantFiled: June 2, 1995Date of Patent: July 15, 1997Assignee: Ciba-Geigy CorporationInventor: Tyler Arthur Stevenson
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Patent number: 5641783Abstract: Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocycle. R.sub.3 may be either hydrogen or C.sub.1-3. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.Type: GrantFiled: September 8, 1994Date of Patent: June 24, 1997Assignee: Cell Therapeutics, Inc.Inventors: J. Peter Klein, Gail E. Underiner, Anil M. Kumar
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Patent number: 5637714Abstract: Esters or phenol ethers of the formula I or II ##STR1## in which m and n are each an integer from the range from 1 to 6; A.sup.1 is an m-valent hydrocarbon radical having 1 to 30 carbon atoms; or an m-valent hydrocarbon radical having 2 to 30 carbon atoms, which contains the heteroatoms oxygen, nitrogen and/or sulfur and the free valencies of which are located on carbon atoms; and in which A.sup.1, in the case where m=2, additionally is a direct bond;A.sup.2 is an n-valent aromatic or araliphatic hydrocarbon radical having 6 to 30 carbon atoms; or an n-valent aromatic or araliphatic hydrocarbon radical having 5 to 30 carbon atoms, which contains the heteroatoms oxygen, nitrogen and/or sulfur and n free valencies of which are located on those carbon atoms which are a constituent of aromatic rings;R.sup.1 is hydrogen; a hydrocarbon or hydrocarbonoxy radical having 1 to 36 carbon atoms, which is unsubstituted or substituted by --CO--N(R.sup.3).sub.2 or interrupted by --CON(R.sup.3)-- or --N(R.sup.Type: GrantFiled: June 7, 1995Date of Patent: June 10, 1997Assignee: Ciba-Geigy CorporationInventor: Alfred Steinmann
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Patent number: 5637706Abstract: Tris-aryl-s-triazines of formula I, II or III ##STR1## which contain from one one to three resorcinol derived moieties with at least one of said moieties substituted in the 5-position with a phenylalkyl group have UV spectra which are red-shifted to the near UV range and provide excellent stabilization to polymeric substrates against the deleterious effects of actinic light.Type: GrantFiled: June 2, 1995Date of Patent: June 10, 1997Assignee: Ciba-Geigy CorporationInventors: Tyler A. Stevenson, Ramanathan Ravichandran, Mark S. Holt, Thuy N. Phan, Jean-Luc Birbaum, Vien V. Toan
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Patent number: 5633371Abstract: Catechol derivatives of the formula ##STR1## wherein Ra, Rb and Rc have the significance given herein, the ester and ether derivatives thereof which are hydrolyzable under physiological conditions and the pharmaceutically acceptable salts thereof are described and possess valuable pharmacological properties. In particular, they inhibit the enzyme catechol-O-methyltransferase (COMT), a soluble, magnesium-dependent enzyme which catalyses the transference of the methyl group of S-adenosylmethionine to a catechol substrate, whereby the corresponding methyl ethers are formed. Suitable substrates which can be O-methylated by COMT and which can thus be deactivated are, for example, extraneuronal catecholamines and exogeneously-administered therapeutically active substances having a catechol structure.Formula Ia above embraces not only compounds which form part of the invention, but also known compounds: the compounds which form part of the invention can be prepared according to known methods.Type: GrantFiled: September 15, 1995Date of Patent: May 27, 1997Assignee: Hoffmann-La Roche Inc.Inventors: Karl Bernauer, Janos Borgulya, Hans Bruderer, Mos e Da Prada, Gerhard Z urcher
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Patent number: 5629265Abstract: Disclosed herein are cyanoketone derivatives of the following formula (1) ##STR1## such as 1-cyano-1-piperidinocarbonyl-3-[4-(2-chloro-4-trifluoromethylphenoxy)pheno xy]-2-butanone, 1-cyano-1-piperidinocarbonyl-3-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy )phenoxy]-2-butanone, 1-cyano-1-(N-methyl-N-dichlorophenyl)aminocarbonyl-3-[4-(2-quinoxalyloxy)p henoxy]-2-butanone, 1-cyano-1-(N,N-dibutyl)aminocarbonyl-3-[4-(3-chloro-5-trifluoromethyl-2-py ridyloxy)phenoxy-2-butanone, and the like, which are characterized by excellent herbicidal activity and effectiveness against a variety of gramineous weeds.Type: GrantFiled: June 22, 1994Date of Patent: May 13, 1997Assignee: Tokuyama CorporationInventors: Masahiko Ishizaki, Seiji Nagata, Junji Takenaka
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Patent number: 5616708Abstract: Compounds of the following formula are provided: ##STR1## in which R.sup.1 represents a hydrogen atom or an optionally substituted alkyl, cycloalkyl, haloalkyl, alkenyl, alkynyl, aryl or aralkyl group,A and B both represent a nitrogen atom, or represents a group CR.sup.5 and B represents a nitrogen atom or a group CR.sup.6 ;R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each independently represent a hydrogen or halogen atom, a hydroxy or cyano group or an optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, aralkyl, aryl, alkylamino, alkylthio or alkoxy group; andl represents an integer from 1 to 3.Type: GrantFiled: May 30, 1995Date of Patent: April 1, 1997Assignee: Shell Research LimitedInventor: Waldemar F. A. Pfrengle
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Patent number: 5599815Abstract: Compounds represented by the formula (I) and pharmacologically acceptable salts thereof: ##STR1## These compounds have little extrapyramidal effect and thus are effective as an anti-psychotic agent having few side effects.Type: GrantFiled: December 20, 1994Date of Patent: February 4, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Yoshimasa Fukuda, Toshiro Sasaki, Yuuko Nakatani, Yasuyuki Ichimaru, Taiichiro Imanishi
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Patent number: 5597854Abstract: The invention relates to compounds of the formula I ##STR1## in which n is 1 or 2, A is CH or a nitrogen atom, and the other radicals R.sup.1 to R.sup.25 are as defined in claim 1.The compounds of the formula I can advantageously be employed for stabilizing organic material against the harmful effect of light, oxygen and/or heat.Type: GrantFiled: November 9, 1995Date of Patent: January 28, 1997Assignee: Ciba-Geigy CorporationInventors: Jean-Luc Birbaum, Gerhard Rytz, Vien Van Toan, Andreas Valet, Norbert W urms
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Patent number: 5585486Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is (CR.sub.5 R.sub.6).sub.n, (CR.sub.5 R.sub.6).sub.n,-aryl, (CR.sub.5 R.sub.6).sub.n -heteroaryl, X-(CR.sub.5 R.sub.6).sub.n, X-(CR.sub.5 R.sub.6).sub.n -aryl or X-(CR.sub.5 R.sub.6).sub.n -heteroaryl wherein aryl and heteroaryl may be optionally substituted;X is 0 or NR.sub.5 ;R.sub.5 and R.sub.6 are independently H or lower alkyl;R.sub.2 is H, halo, lower alkyl or (CR.sub.5 R.sub.6).sub.n -aryl;R.sub.3 and R.sub.4 are independently H or alkyl;A is a D or L isomer of an amino acid selected from the group consisting of alanine, valine, leucine, isoleucine, proline, phenylalanine, glycine, tyrosine, methionine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine, histidine and .beta.-thienylalanine;Z is CH.sub.2 or O; andn is 0-4;pharmaceutical compositions containing the compounds; and a method for inhibiting interleukin-1.beta.Type: GrantFiled: May 12, 1995Date of Patent: December 17, 1996Assignee: Sterling Winthrop Inc.Inventors: Roland E. Dolle, Todd L. Graybill, Gary J. Speier, Catherine P. Prouty, Stanley J. Schmidt
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Patent number: 5585422Abstract: s-Triazine UV absorbers substituted by a benzotriazolyl or benzophenonyl moiety exhibit unexpectedly improved UV absorption characteristics and outstanding efficacy in protecting organic substances from the deleterious effects of actinic radiation as well as good resistance to loss by volatilization during processing of stabilized compositions at elevated temperatures.Type: GrantFiled: September 20, 1995Date of Patent: December 17, 1996Assignee: Ciba-Geigy CorporationInventors: Robert A. Falk, Tyler A. Stevenson, Gregory R. Coughlin
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Patent number: 5580868Abstract: Novel pyridyloxy-acrylic acid esters of the formula ##STR1## in which Ar represents optionally substituted aryl or represents optionally substituted heteroaryl,a process for preparing the novel compounds and their use as agents for combating pests.Novel intermediates, processes for their preparation and their use for the synthesis of pyridyloxy-acrylic acid esters.Type: GrantFiled: August 13, 1993Date of Patent: December 3, 1996Assignee: Bayer AktiengesellschaftInventors: Winfried Lunkenheimer, Lutz Assmann, Stefan Dutzmann, Heinz-Wilhelm Dehne, Gerd H anssler
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Patent number: 5571773Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.Type: GrantFiled: June 2, 1995Date of Patent: November 5, 1996Assignee: American Cyanamid CompanyInventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
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Patent number: 5556973Abstract: Tris-aryl-s-triazines which contain from one to three resorcinol derived moieties with at least one of said moieties substituted at the 5-position with an alkyl, phenylalkyl, halogen, thio or sulfonyl group have UV spectra which are red-shifted to the near UV range and provide excellent stabilization to polymeric substrates against the deleterious effects of actinic light.Type: GrantFiled: July 27, 1994Date of Patent: September 17, 1996Assignee: Ciba-Geigy CorporationInventors: Tyler A. Stevenson, Ramanathan Ravichandran, Mark S. Holt, Thuy N. Phan, Jean-Luc Birbaum, Vien V. Toan
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Patent number: 5545835Abstract: There are provided 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds, a method for the preparation thereof and the use thereof for the preparation of 5-(substituted methyl)-2,3-pylidinedicarboxylic acids.Type: GrantFiled: November 4, 1994Date of Patent: August 13, 1996Assignee: American Cyanamid CompanyInventor: Henry L. Strong
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Patent number: 5543518Abstract: Tris-aryl-s-triazines which contain from one to three resorcinol derived moieties with at least one of said moieties substituted at the 5-position with an alkyl, phenylalkyl, halogen, thio or sulfonyl group have UV spectra which are red-shifted to the near UV range and provide excellent stabilization to polymeric substrates against the deleterious effects of actinic light.Type: GrantFiled: June 2, 1995Date of Patent: August 6, 1996Assignee: Ciba-Geigy CorporationInventors: Tyler A. Stevenson, Ramanathan Ravichandran, Mark S. Holt, Thuy N. Phan, Jean-Luc Birbaum, Vien V. Toan
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Patent number: 5523379Abstract: A high molecular weight stabilizer compound formed as an ester of 3-(2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxy-benzene-propanoic acid, or structural variants thereof, to impart improved resistance to the effects of ultraviolet radiation to polycarbonate comprising polymers, a process for the preparation of said compound, and articles of manufacture comprising said compound.Type: GrantFiled: December 21, 1994Date of Patent: June 4, 1996Assignee: General Electric PlasticsInventor: Niles R. Rosenquist
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Patent number: 5510379Abstract: .beta.-Carboxy sulfonates of the formula ##STR1## wherein R.sub.1 is aryl, R.sub.3 and R.sub.4 are hydrogen or alkyl, Y is -O-, -S-, or -NR.sub.2 -, and R.sub.5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia and atherosclerosis.Type: GrantFiled: December 19, 1994Date of Patent: April 23, 1996Assignee: Warner-Lambert CompanyInventors: Helen T. Lee, Joseph A. Picard, Drago R. Sliskovic
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Patent number: 5502189Abstract: Compounds which comprise at least one group of the formula I or II ##STR1## and at least one polyalkylpiperidine group of the formula III ##STR2## in which R and R.sub.1 to R.sub.6 have the meaning indicated in claim 1, are effective stabilisers for organic materials against damage by light, oxygen and heat.Type: GrantFiled: October 6, 1994Date of Patent: March 26, 1996Assignee: Ciba-Geigy CorporationInventors: Mario Slongo, Jean-Luc Birbaum, Jean Rody, Andreas Valet
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Patent number: 5489632Abstract: Novel imino ether compounds, processes for their production and methods for their use are provided. These novel imino ether compounds are particularly useful as light stabilizers for polymeric compositions, particularly for lacquer coating compositions.Type: GrantFiled: July 28, 1993Date of Patent: February 6, 1996Assignee: Sandoz Ltd.Inventor: Lajos Avar
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Patent number: 5484919Abstract: A chromophore-substituted halomethyl-1,3,5-triazine photopolymerization initiator. The initiator preferably comprises three moleties--a residue of a hydroxyl-substituted, chromophore-substituted, halomethyl-1,3,5-triazine compound; a residue of a diisocyanate compound having isocyanato groups of dissimilar reactivities; a residue of a hydroxyl-substituted compound, e.g., the residue of a polyoxyethylene alkylphenol.Type: GrantFiled: February 1, 1994Date of Patent: January 16, 1996Assignee: Minnesota Mining and Manufacturing CompanyInventor: James A. Bonham
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Patent number: 5457204Abstract: Esters or phenol ethers of the formula I or II ##STR1## in which m and n are each an integer from the range from 1 to 6; A.sup.1 is an m-valent hydrocarbon radical having 1 to 30 carbon atoms; or an m-valent hydrocarbon radical having 2 to 30 carbon atoms, which contains the heteroatoms oxygen, nitrogen and/or sulfur and the free valencies of which are located on carbon atoms; and in which A.sup.1, in the case where m=2, additionally is a direct bond;A.sup.2 is an n-valent aromatic or araliphatic hydrocarbon radical having 6 to 30 carbon atoms; or an n-valent aromatic or araliphatic hydrocarbon radical having 5 to 30 carbon atoms, which contains the heteroatoms oxygen, nitrogen and/or sulfur and n free valencies of which are located on those carbon atoms which are a constituent of aromatic rings;R.sup.1 is hydrogen; a hydrocarbon or hydrocarbonoxy radical having 1 to 36 carbon atoms, which is unsubstituted or substituted by --CO--N(R.sup.3).sub.2 or interrupted by --CO--N(R.sup.3)-- or --N(R.sup.Type: GrantFiled: July 7, 1994Date of Patent: October 10, 1995Assignee: Ciba-Geigy CorporationInventor: Alfred Steinmann
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Patent number: 5447904Abstract: The invention relates to new 3-aryl-triazine-2,4-diones of the general formula (I) ##STR1## in which Het represents a radical of the formula ##STR2## R.sup.1 represents hydrogen or halogen, R.sup.2 represents halogen, cyano or nitro andR.sup.3 represents a radical of the formula --X--R.sup.6 or --CO--X--R.sup.7, in whichR.sup.4 represents hydrogen, cyano, alkyl, alkenyl, alkinyl or halogenoalkyl,R.sup.5 represents alkyl, alkenyl or alkinyl,R.sup.6 represents hydrogen or optionally substituted alkyl,R.sup.7 represents hydrogen or optionally substituted alkyl,X represents oxygen or sulphur andZ represents oxygen or sulphur, to a process for their preparation, to new intermediates, and to their use as herbicides.Type: GrantFiled: August 17, 1993Date of Patent: September 5, 1995Assignee: Bayer AktiengesellschaftInventors: Otto Schallner, Klaus Lurssen, Hans-Joachim Santel, Robert R. Schmidt, Renate Vosswinkel