Bonded To Triazine Ring Carbon Patents (Class 544/216)
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Publication number: 20080217580Abstract: The present invention relates to compounds of formula (I) a process for their production and to their use for coloring high molecular weight organic materials, as fluorescent tracers, in solid dye lasers, EL lasers, in EL devices and lighting. The compounds of formula I show unique broadband luminescence in visible region.Type: ApplicationFiled: April 11, 2005Publication date: September 11, 2008Inventors: Junichi Tanabe, Hiroshi Yamamoto, Norihisa Dan
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Publication number: 20080142429Abstract: Membranes comprising functional polyarylether having structural units of formula II are useful for hemodialysis and hemofiltration: wherein X is selected from Br, NR4R5, OOCR6, OR7, NR4COR5, NR4CONR5R6, NR4COOR5R6 and combinations thereof; R1, R2 and R3 are independently at each occurrence H, X, halo, cyano, nitro, a C1-C12 aliphatic radical, a C3-C12 cycloaliphatic radical, a C3-C12 aromatic radical or a combination thereof; R4 and R5 are independently H, a C1-10 aliphatic radical, a C3-C12cycloaliphatic radical, a C3-C12 aromatic radical, or a combination thereof; R6 is H, a C2-10 aliphatic radical, a C3-C12 cycloaliphatic radical, a C3-C12 aromatic radical or a combination thereof; R7 is OCH2CH2(OCH2CH2)nOH or OOCCH2(OCH2CH2)nCH3; Q is a direct bond, O, S, CH2, alkenyl, alkynyl, a C1-C12 aliphatic radical, a C3-C12 cycloaliphatic radical, a C3-C12 aromatic radical or a combination thereof; Z is a direct bond, O, S, CH2, SO, SO2, CO, phenylphospinyl oxide, alkenyl, alkynyl, a C1-C12aliphatic radical,Type: ApplicationFiled: December 15, 2006Publication date: June 19, 2008Applicant: GENERAL ELECTRIC COMPANYInventors: Yanshi Zhang, Daniel Steiger, Joseph Anthony Suriano, Gary William Yeager
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Patent number: 7294714Abstract: The present invention relates to highly compatible hydroxyphenyltriazine UV-absorbers and to their use in protecting plants in green houses and the protection of foodstuffs, beverages, pharmaceuticals, cosmetics, personal care products, shampoos and the like from the deleterious effects of ultraviolet radiation. It has been found that certain highly compatible tris-aryl-s-triazines are especially effective towards this end when incorporated in the containers or films in which such materials are stored.Type: GrantFiled: September 22, 2006Date of Patent: November 13, 2007Assignee: Ciba Specialty Chemicals Corp.Inventors: Dario Lazzari, David George Leppard, Massimiliano Sala, Manuele Vitali, Graziano Zagnoni, Gianluca Ferri
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Patent number: 7291616Abstract: The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor cells.Type: GrantFiled: October 30, 2002Date of Patent: November 6, 2007Assignee: Cell Therapeutics, Inc.Inventors: Rama Bhatt, Baoqing Gong, Feng Hong, Scott A. Jenkins, J. Peter Klein, Anil M. Kumar, John Tulinsky
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Patent number: 7220732Abstract: The present invention relates to compounds of the formula or a salt, metal complex or hydrate or other solvate thereof, wherein: M is a chelating agent; R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of: H; a substituted or unsubstituted, saturated or unsaturated, cyclic, moiety; a substituted or unsubstituted, saturated or unsaturated, heterocyclic moiety; or a substituted or unsubstituted, saturated or unsaturated, straight or branched chain alkyl or acyl moiety; and R2and R5 may also be independently a heavy atom or a water-solubilizing group. The present invention also relates to use of these compounds in the therapy in vivo or in vitro of a photosensitive target biological cell by irradiation, as well as methods of treating a photosensitive target biological cell in vivo or in vitro. Finally, the present invention relates to pharmaceutical compositions, comprising these compounds, in association with a pharmaceutically acceptable diluent or carrier.Type: GrantFiled: March 24, 2003Date of Patent: May 22, 2007Inventors: Donal O'Shea, John Killoran, William Gallagher
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Patent number: 7205302Abstract: The present invention provides a compound which is useful as a PGI2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]: (R1 and R2 are the same or different and each represents optionally substituted aryl, Y represents N or CH, Z represents N or CH, A represents NH, NR5, O, S, or ethylene, R5 represents alkyl, D represents alkylene or alkenylene, E represents phenylene or single bond, G represents O, S, or CH2, R3 and R4 are the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, or N-(alkylsulfonyl)carbamoyl), or a pharmaceutically acceptable salt thereof as an active ingredient.Type: GrantFiled: April 25, 2002Date of Patent: April 17, 2007Assignee: Nippon Shinyaku Co., Ltd.Inventors: Tetsuo Asaki, Taisuke Hamamoto, Keiichi Kuwano
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Patent number: 7189719Abstract: The present invention relates to a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels.Type: GrantFiled: April 21, 2004Date of Patent: March 13, 2007Assignee: Parion Sciences, Inc.Inventor: Michael R. Johnson
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Patent number: 7179907Abstract: The present invention provides methods for identifying (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity. The method involves the selection of RNA biocatalysts that promote the formation of (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity from component reactants. The invention also provides novel (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity identified by these methods. The invention also provides RNA biocatalysts that are capable of catalyzing the formation of (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives from component reactants.Type: GrantFiled: December 18, 2002Date of Patent: February 20, 2007Inventors: Bruce Eaton, Theodore M. Tarasow, Dan Nieuwlandt, Torin Dewey
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Patent number: 7173032Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.Type: GrantFiled: March 17, 2003Date of Patent: February 6, 2007Assignee: Reddy US Therapeutics, Inc.Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Karen A. Campbell
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Patent number: 7132418Abstract: The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.Type: GrantFiled: July 25, 2002Date of Patent: November 7, 2006Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Michael J. Costanzo, Bruce E. Maryanoef, Stephen C. Yabut
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Patent number: 7125920Abstract: The present invention relates to an ultraviolet absorber for synthetic resins composed of a triazine compound represented by the general formula (I) shown below (wherein R represents an alkyl group having 1 to 4 carbon atoms, n is 0 or an integer of up to 2, and X represents a group selected from the consisting of group (a) to (d) shown below) (wherein R1 represents an aliphatic group having 5 to 60 carbon atoms, which is an alicyclic group, an alkyl group having an alicyclic group at the terminal or in the chain thereof, an alkyl group having a branch, or a linear alkyl group, depending on the number of carbon atoms; R2 represents an alkyl group having 1 to 18 carbon atoms or a (poly)alkyleneoxyalkyl group; R? represents an aliphatic diyl group having 5 to 60 carbon atoms; R and n have the same meanings as those described in the general formula (I) above).Type: GrantFiled: April 8, 2002Date of Patent: October 24, 2006Assignee: Asahi Denka Kogyo K.K.Inventors: Yoshinori Negishi, Etsuo Tobita, Takashi Ayabe
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Patent number: 7030117Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.Type: GrantFiled: October 27, 2004Date of Patent: April 18, 2006Assignee: Parion Sciences, Inc.Inventor: Michael R. Johnson
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Patent number: 7026478Abstract: A process for the production of compounds Ar—R1 by means of a cross-coupling reaction of an organometallic reagent R1-M with an aromatic or heteroaromatic substrate Ar—X catalyzed by one or several iron salts or iron complexes as catalysts or pre-catalysts, present homogeneously or heterogeneously in the reaction mixture. This new invention exhibits substantial advantages over established cross coupling methodology using palladium- or nickel complexes as the catalysts. Most notable aspects are the fact that (i) expensive and/or toxic nobel metal catalysts are replaced by cheap, stable, commercially available and toxicologically benign iron salts or iron complexes as the catalysts or pre-catalysts, (ii) commercially attractive aryl chlorides as well as various aryl sulfonates can be used as starting materials, (iii) the reaction can be performed under “ligand-free” conditons, and (iv) the reaction times are usually very short.Type: GrantFiled: May 10, 2002Date of Patent: April 11, 2006Assignee: Studiengesellschaft Kohle mbHInventors: Alois Fürstner, Andreas Leitner, María Méndez
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Patent number: 6943161Abstract: Compounds that selectively inhibit inappropriate kinase activities and methods for their preparation are disclosed. In one embodiment, the compounds are represented by Formula I, As selective inhibitors of inappropriate kinase activities, the compounds of the present invention are useful in the treatment of conditions associated with such activity, including, but not limited to, inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting inappropriate kinase activities and methods of treating conditions associated with such activities.Type: GrantFiled: June 28, 2002Date of Patent: September 13, 2005Assignee: Pharmacopela Drug Discovery, Inc.Inventors: Shawn David Erickson, James Inglese, Jeffrey John Letourneau, Christopher Mark Riviello
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Patent number: 6924330Abstract: A compound of the formula (I) wherein G1, G2, G3 and G4 are independently of one another C1-C18alkyl or C5-C12cycloalkyl or the radicals G1 and G2 and the radicals G3 and G4 form independently of one another, together with the carbon atom they are attached to, C5-C12cycloalkyl; R is hydrogen, C1-C18alkyl, oxyl, —OH, —CH2CN, C3-C6alkenyl, C3-C8alkynyl, C7-C12phenylalkyl unsubstituted or substituted on the phenyl radical by C1-C4alkyl and/or C1-C4alkoxy; C1-C8acyl, C1-C18alkoxy, C1-C18hydroxyalkoxy, C2-C18alkenyloxy, C5-C12cycloalkoxy, C7-C12phenylalkoxy unsubstituted or substituted on the phenyl radical by C1-C4alkyl and/or C1-C4alkoxy; C1-C18alkanoyloxy, (C1-C18alkoxy)carbonyl, glycidyl or a group —CH2CH(OH)(G) with G being hydrogen, methyl or phenyl; n is 1, 2, 3 or 4; and X is an organic radical of a valency equal to n; and when n is 2, 3 or 4, each of the radicals G1, G2, G3, G4 and R can have the same or a different meaning in the units of the formula (II), is useful for stabilizing an organic material agType: GrantFiled: February 19, 2001Date of Patent: August 2, 2005Assignee: Ciba Specialty Chemicals Corp.Inventors: Dario Lazzari, Graziano Zagnoni
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Patent number: 6919454Abstract: Biphenyl-substituted triazines of the formula which are notable for high thermal stability, are used as stabilizers for organic polymers to counter damage thereto caused by light, oxygen and heat, as light stabilizers for textile fiber materials and as sunscreens for the human skin.Type: GrantFiled: August 18, 2004Date of Patent: July 19, 2005Assignee: Ciba Specialty Chemicals Corp.Inventors: Ian John Fletcher, Jürgen Kaschig, Georges Metzger, Dieter Reinehr, Pascal Hayoz
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Patent number: 6900314Abstract: It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoters are combined to form a complex. 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.Type: GrantFiled: April 30, 2004Date of Patent: May 31, 2005Assignee: Cytec Technology Corp.Inventors: Ram B. Gupta, Dennis J. Jakiela, Sampath Venimadhavan, Russell C. Cappadona, Venkatrao K. Pai
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Patent number: 6867250Abstract: The invention relates generally to pyrimidines and triazines ultraviolet light absorbers containing a phenolic aromatic group(s) and a non-phenolic aromatic group(s) and the use thereof to protect against degradation by environmental forces, inclusive of ultraviolet light, actinic radiation, oxidation, moisture, atmospheric pollutants, and combinations thereof. The new class of pyrimidines and triazines includes two (one) non-phenolic aromatic groups with hydrocarbyl groups that are ortho to each other and one (two) resorcinol or substituted resorcinol group attached to a triazine or pyrimidine ring. The pyrimidines and triazines may be included in a polymeric structure. A method for stabilizing a material by incorporating the novel pyrimidines and triazines is also disclosed.Type: GrantFiled: October 30, 2000Date of Patent: March 15, 2005Assignee: Cytec Technology Corp.Inventors: Ram B. Gupta, Hargurpreet Singh, Russell C. Cappadona, Mark Paterna, Al Wagner
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Patent number: 6855269Abstract: This invention relates generally to phenyl ether substituted triazines compounds and compositions containing same and their use to protect against degradation by environmental forces. A method for stabilizing a material by incorporating such triazines is also disclosed.Type: GrantFiled: November 9, 2001Date of Patent: February 15, 2005Assignee: Cytec Technology Corp.Inventors: Ram Baboo Gupta, Hargurpreet Singh, Russell C. Cappadona
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Patent number: 6841670Abstract: Biphenyl-substituted triazines of the formulae which are notable for high thermal stability, are used as stabilizers for organic polymers to counter damage thereto caused by light, oxygen and heat, as light stabilizers for textile fiber materials and as sunscreens for the human skin.Type: GrantFiled: July 31, 2002Date of Patent: January 11, 2005Assignee: Ciba Specialty Chemicals CorporationInventors: Ian John Fletcher, Jürgen Kaschig, Georges Metzger, Dieter Reinehr
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Publication number: 20040162290Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.Type: ApplicationFiled: November 10, 2003Publication date: August 19, 2004Applicant: Neurocrine Biosciences, Inc.Inventors: Zhiqiang Guo, Dongpei Wu, Chen Chen, Fabio Tucci, Collin Regan
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Patent number: 6730785Abstract: It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoters are combined to form a complex. 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.Type: GrantFiled: February 9, 2001Date of Patent: May 4, 2004Assignee: Cytec Technology Corp.Inventors: Ram B. Gupta, Dennis J. Jakiela, Sampath Venimadhavan, Russell C. Cappadona, Venkatrao K. Pai
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Patent number: 6730668Abstract: The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: wherein R comprises ethers or amines; R1 is: a) substituted or unsubstituted aryl; or b) substituted or unsubstituted heteroaryl; each R2 unit is independently selected from the group consisting of: a) hydrogen; b) —(CH2)jO(CH2)nR8; c) —(CH2)jNR9aR9b; d) —(CH2)jCO2R10; e) —(CH2)jOCO2R10 f) —(CH2)jCON(R10)2; g) —(CH2)jOCON(R10)2; h) two R2 units can be taken together to form a carbonyl unit; i) and mixtures thereof; R8, R9a, R9b, and R10 are each independently hydrogen, C1-C4 alkyl, and mixtures thereof; R9a and R9b can be taken together to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms; two R10 units can be take together to form a carbocyclic or heterocyclic ringType: GrantFiled: September 18, 2002Date of Patent: May 4, 2004Assignee: The Procter & Gamble CompanyInventors: Michael Philip Clark, Matthew John Laufersweiler, Jane Far-Jine Djung, Michael George Natchus, Biswanath De
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Patent number: 6710177Abstract: It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoters are combined to form a complex. 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.Type: GrantFiled: February 9, 2001Date of Patent: March 23, 2004Assignee: Cytec Technology Corp.Inventors: Ram B. Gupta, Dennis J. Jakiela, Sampath Venimadhavan, Russell C. Cappadona, Venkatrao K. Pai
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Patent number: 6706743Abstract: The instant invention provides &bgr;3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, wherein Ar, R, R1, R2, R3, R4, R5, R6, R7, R8, X, and Y, are as defined herein.Type: GrantFiled: March 5, 2003Date of Patent: March 16, 2004Assignee: Pfizer IncInventors: Robert F. Day, Jennifer A. Lafontaine
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Publication number: 20040002599Abstract: The invention relates to novel substituted benzoylcyclohexenones of the formula (I), 1Type: ApplicationFiled: October 21, 2002Publication date: January 1, 2004Inventors: Klaus-Helmut Muller, Hans-Georg Schwarz, Stefan Herrmann, Dorothee Hoischen, Stefan Lehr, Otto Schallner, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Akihiko Yanagi, Shinichi Narabu, Toshio Goto, Seishi Ito, Chieko Ueno
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Patent number: 6664391Abstract: Novel N-fluorotriazinium electrophilic fluorinating agents have the Formula I: wherein three A moieties are independently CR, where each R is, independently, hydrogen, halogen, hydroxyl, (primary, secondary or tertiary) amino, amino, cyano, perfluorothio, hydroxysulfonyl, halosulfonyl, hydrocarbyloxysulfonyl, or a carbon-containing substituent selected from the group consisting of optionally substituted hydrocarbyl, hydrocarbyloxy, hydrocarbyloxycarbonyl, and hydrocarbylthio groups, and at least one R is neither hydrogen nor halogen; two A moieties are independently Z, where each Z is independently nitrogen or a quaternary nitrogen atom and Y is a counterion or group of counterions which are inert to chemical attack by fluorine, or adjacent triazinium moieties are linked by a common R substituent to provide an oligomer or polymer.Type: GrantFiled: October 23, 2001Date of Patent: December 16, 2003Assignee: Air Products and Chemicals, Inc.Inventors: Ronald Eric Banks, Mohamed Khalifa Besheesh
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Patent number: 6635760Abstract: Aromatic compounds having one or more electron-withdrawing substituents are fluorinated, preferably in a nitromethane solvent, by contact with tri(halo- or trifluoromethyl) substituted N-fluorotriazinium salts of the following Formula I: wherein three A moieties are independently CR, where each R is independently halogen or trifluoromethyl; two A moieties are independently Z, where each Z is independently nitrogen or a quaternary nitrogen atom and Y is a counterion or group of counterions which are inert to chemical attack by fluorine. Preferably the cation of the salt is 2,4,6-trichloro-1,3,5-triazinium.Type: GrantFiled: October 23, 2001Date of Patent: October 21, 2003Assignee: Air Products and Chemicals, Inc.Inventors: Ronald Eric. Banks, Mohamed Khalifa Besheesh
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Patent number: 6632817Abstract: The invention relates to novel fluoromethoximino compounds, to a process for their preparation and to their use as pesticides, and also to novel intermediates and to a plurality of processes for their preparation.Type: GrantFiled: August 20, 2001Date of Patent: October 14, 2003Inventors: Ulrich Heinemann, Herbert Gayer, Peter Gerdes, Albrecht Marhold, Uwe Stelzer, Reinhard Lantzsch, Ralf Tiemann, Klaus Stenzel, Astrid Mauler-Machnik, Stefan Dutzmann, Martin Kugler, Hans-Ulrich Buschhaus
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Patent number: 6632944Abstract: This invention relates to a novel, efficient, economic and general-purpose process for isolating monophenolic-bisaryl triazine compounds from polyphenolic-triazines compounds and other impurities. More specifically, this invention relates to a process for isolating the monophenolic-bisaryl triazine compounds by contacting it with a base, an alcohol or a hydrocarbon solvent.Type: GrantFiled: June 22, 2001Date of Patent: October 14, 2003Assignee: Cytec Technology Corp.Inventors: Ram Baboo Gupta, Hargurpreet Singh, Russell C. Cappadona
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Publication number: 20030158197Abstract: The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY1 receptor.Type: ApplicationFiled: November 8, 2002Publication date: August 21, 2003Applicant: NEUROGEN CORPORATIONInventors: Raymond F. Horvath, Jennifer N. Tran, Stephane De Lombaert, Kevin J. Hodgetts, Philip A. Carpino, David A. Griffith
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Patent number: 6608122Abstract: o-Hydroxyphenyl-s-triazines of the formula I in which n is 1 to 4 and R1 to R7 are as defined in claim 1, can be used, in combination with sterically hindered amines of the polyalkylpiperidine type, for stabilizing organic polymers. Some of these compounds are novel and can also be used without polyalkylpiperidine.Type: GrantFiled: October 5, 2000Date of Patent: August 19, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Luc Birbaum, Jean Rody, Mario Slongo, Andreas Valet, Roland A. E. Winter
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Patent number: 6608061Abstract: A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1—S—R1—S—Ar2 wherein R1 represents a nonmetal bridging group; Ar1 and Ar2 independently represent a group selected from the group consisting of an aryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group and said aryl group may have one to three substituents other than hydroxyl group on its ring; and a heteroaryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group, and said heteroaryl group may have one to three substituents other than hydroxyl group on its ring.Type: GrantFiled: February 14, 2000Date of Patent: August 19, 2003Assignees: Kyoma Hakko Kogyo Co., Ltd., Fuji Photo Film Co., Ltd.Inventors: Yoshiyuki Yonetani, Takeshi Takahashi, Yuko Kanda, Tamio Mizukami, Tatsuya Tamaoki, Shun-ichi Ikeda, Masanobu Takashima, Naoki Asanuma, Tadashi Inaba, Hiroshi Takeuchi, Hiroshi Kawamoto, Yoshihisa Tsukada, Masato Satomura, Hiroshi Kitaguchi
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Patent number: 6582624Abstract: A method and composition for reducing the levels of hydrogen sulphide and mercaptans in hydrocarbon streams. The method comprises contacting the gas stream with a composition comprising the reaction product of mixing monoethanolamine, diglycolamine and formaldehyde. The use of the method and composition alleviates problems associated with crystalline dithiazine depost build-up associated with the use of triazine based scavengers.Type: GrantFiled: February 1, 2001Date of Patent: June 24, 2003Assignee: Canwell Enviro-Industries, Ltd.Inventors: Clive Willaim Titley, Peter Hans Wieninger
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Publication number: 20030100759Abstract: The present invention relates to dideoxynucleoside analog compounds containing a dideoxy ribofuranosyl moiety that exhibit selective anti-viral activity coupled with substantially low toxicity toward the host cells. In particular, the compounds according to the present invention show potent inhibition of the replication of the human immunodeficiency virus (HIV), while remaining substantially inert toward host cell DNA. Compounds according to the present invention exhibit primary utility as agents for inhibiting the growth or replication of retroviruses, particularly HIV. The compounds of the invention comprise a (2,3 ′-dideoxy-&bgr;-ribofuranosyl) ring coupled to a heterocyclic nucleobase that lacks an “O2 carbonyl”, that enables them to selectively react with and inhibit viral reverse transcriptase, while remaining substantially unreactive toward human DNA polymerases.Type: ApplicationFiled: March 13, 2002Publication date: May 29, 2003Inventors: Larry W. McLaughlin, Andrew W. Fraley, DongLi Chen, Tao Lan
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Patent number: 6559147Abstract: This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: wherein Z1, Z2, R1, R2, R3, R4, R5, R6, and R7 are defined herein. These compounds are useful as anti-coagulants.Type: GrantFiled: May 4, 2001Date of Patent: May 6, 2003Assignee: Berlex Laboratories, Inc.Inventor: Gary B. Phillips
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Patent number: 6528455Abstract: Phenoxy- and thiophenoxyacrylic acid compounds of the formula I in which Het, R1, R2, R3, V, W and Z are as defined in claim 1 and processes for their preparation, intermediates for their preparation, herbicidally active compositions comprising the compounds of the formula I and a method for controlling harmful fungi are described.Type: GrantFiled: June 5, 2002Date of Patent: March 4, 2003Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, Michael Puhl, Robert Reinhard, Ingo Sagasser, Cyrill Zagar, Karl-Otto Westphalen, Matthias Witschel, Helmut Walter
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Patent number: 6509400Abstract: Compounds of the formula in which Z, Z′ and Z″ independently of one another are a group of the formula II and R7 is a radical of the formula III, IV or V in which n is 1 or 2; R4, R5 and R6 independently of one another are C1-C18alkyl; C5-C12cycloalkyl; C2-C18alkenyl; phenyl; C7-C11phenylalkyl; C7-C11alkylphenyl; C1-C18alkyl substituted by phenyl, OH, C1-C18alkoxy, C5-C12cycloalkoxy, C3-C18alkenyloxy, COOH, COOR11, O—COR12, CONH2, CONHR13, CONR13R14, CN, NH2, NHR13, NR13R14, NHCOR12, C6-C15bicycloalkyl, C6-C16bicycloalkyl-alkoxy, C6-C16bicycloalkenyl-alkoxy or C6-C15tricycloalkoxy; C5-C12cycloalkyl substituted by OH, C1-C4alkyl, C2-C6alkenyl or O—COR12; or COR15; CO—X—R11; or SO2—R16; or C3-C50alkyl interrupted by O and/or substituted by OH, phenoxy or C7-C18alkylphenoxy; or R5 and R6 together form a ring structure; X and Y independently of one another are O, NH, NR13 or S; and the other symbols are as defined in cType: GrantFiled: October 9, 2001Date of Patent: January 21, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Thomas Schäfer, Thomas Bolle, Pascal Hayoz
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Patent number: 6495684Abstract: This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formula: wherein Z1, Z2, R1, R2, R3, R4, R5, R6, and R7 are defined herein. These compounds are useful as anti-coagulants.Type: GrantFiled: May 4, 2001Date of Patent: December 17, 2002Assignee: Berlex Laboratories, Inc.Inventor: Gary B. Phillips
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Patent number: 6486317Abstract: The invention provides new processes for preparing compositions containing at least one triazine compound, including new compounds for use in these processes to form the compositions and the new compositions that are formed.Type: GrantFiled: October 18, 2000Date of Patent: November 26, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Ram B. Gupta, Dennis J. Jakiela, Sampath Venimadhavan, Russell C. Cappadona, Venkatrao K. Pai
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Patent number: 6486316Abstract: It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoters are combined to form a complex. 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.Type: GrantFiled: November 17, 1999Date of Patent: November 26, 2002Assignee: Cytec Technology Corp.Inventors: Ram B. Gupta, Dennis J. Jakiela, Sampath Venimadhavan, Russell C. Cappadona, Venkatrao K. Pai
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Publication number: 20020158352Abstract: The present invention relates to a triazine type monomer, and more particularly, to a 1,3,5-triazine type monomer characterized by having at least one amine group and at least two sulfur atoms, which can be used in manufacturing transparent optical resins having excellent refractive index, surface hardness and absorbance as well as an improved workability and the ability to control a wide range of refractive index according to the change in composition by the monomer itself at room temperature or by polymerizing the monomer with a comonomer in the presence of an organic solvent or an initiator.Type: ApplicationFiled: August 10, 2001Publication date: October 31, 2002Inventor: Eun Kyoung Kim
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Patent number: 6469006Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.Type: GrantFiled: May 16, 2000Date of Patent: October 22, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Wade S. Blair, Milind Deshpande, Haiquan Fang, Pin-Fang Lin, Timothy P. Spicer, Owen B. Wallace, Hui Wang, Tao Wang, Zhongxing Zhang, Kap-Sun Yeung
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Patent number: 6468958Abstract: Biphenyl-substituted triazines of the formulae which are notable for high thermal stability, are used as stabilizers for organic polymers to counter damage thereto caused by light, oxygen and heat, as light stabilizers for textile fiber materials and as sunscreens for the human skin.Type: GrantFiled: May 3, 2001Date of Patent: October 22, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Ian John Fletcher, Jürgen Kaschig, Georges Metzger, Dieter Reinehr, Pascal Hayoz
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Patent number: 6458758Abstract: Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxide free radicals for use in cell-free hemoglobin solutions, encapsulated hemoglobin solutions, stabilized hemoglobin solutions, polymerized hemoglobin solutions, conjugated hemoglobin solutions, nitroxide-labelled albumin, and nitroxide-labelled immunoglobulin. Formulations are described herein that interact with free radicals, acting as antioxidant enzyme-mimics, which preserve nitroxides in their active form in vivo. Applications are described including blood substitutes, radioprotective agents, imaging agents, agents to protect against ischemia and reperfusion injury, particularly in cerebral ischemia in stroke, and in vivo enzyme mimics among others.Type: GrantFiled: March 26, 1997Date of Patent: October 1, 2002Assignee: Synzyme Technologies, Inc.Inventor: Jen-Chang Hsia
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Patent number: 6437123Abstract: A compound of the present invention is a triazine compound of the general formula: Ar, Ar′ and Ar″ are aromatic moieties which are conjugated to the triazine core and are the same or different. Each of R1, R1′, R1″ to Rn, Rn′, Rn″, which may be the same or different, is an elongated flexible, at least partly aliphatic chain such as to impart liquid-crystalline or columnar crystalline properties to the compound or its mixtures. —(R1, . . . , Rn), —(R1′, . . . , Rn′) and —(R1″, . . . , Rn″) indicate that there are up to n, n′ and n″ substituent groups R on respective Ar, Ar′, Ar″ moieties, where n, n′ and n″ are integers which do not exceed a number of available substituent positions on the respective Ar, Ar′, Ar″ moieties.Type: GrantFiled: April 27, 1999Date of Patent: August 20, 2002Assignee: Sharp Kabushiki KaishaInventors: Harald Reinhart Bock, Sally Anderson, Yoshimasa Fujita, Andrew James Hudson, Judy Megan Rorison, Michael Stuart Weaver
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Patent number: 6426346Abstract: The present application describes 6-membered aromatics of formula I: or pharmaceutically acceptable salt forms thereof, wherein D may be CH2NH2 or C(═NH)NH2, which are useful as inhibitors of factor Xa.Type: GrantFiled: February 15, 2000Date of Patent: July 30, 2002Assignee: Bristol - Myers Squibb Pharma CompanyInventors: James Russell Pruitt, Donald Joseph Phillip Pinto, Mimi Lifen Ouan, Ruth Richmond Wexler
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Patent number: 6423842Abstract: The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.Type: GrantFiled: October 5, 2001Date of Patent: July 23, 2002Assignee: UCB, S.A.Inventors: Gurmit Grewal, Anna Toy-Palmer, Xiong Cai, George Mark Latham
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Patent number: 6417357Abstract: This invention relates to a novel, inventive process for the preparation of biphenyls or aromatic olefins by coupling reactions of the Suzuki coupling and Heck coupling type, using allylpalladium catalysts of the &mgr;-halo(triisopropylphosphine)(&eegr;3-allyl)palladium(II) type.Type: GrantFiled: September 14, 2000Date of Patent: July 9, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Michael Tinkl, Andreas Hafner
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Patent number: 6399620Abstract: There are described cycloalkyl derivatives of the formula (I) R1—Y—A—B—D—E—F—G (I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin receptor antagonists and as inhibitors of bone resorption.Type: GrantFiled: June 29, 2000Date of Patent: June 4, 2002Assignee: Aventis Pharma S.A.Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Jean-Francois Gourvest, Denis Carniato, Thomas Richard Gadek, Robert McDowell, Robert Maurice Pitti, Sarah Catherine Bodary