Phenanthridines (including Hydrogenated) Patents (Class 546/108)
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Patent number: 6723733Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.Type: GrantFiled: May 15, 2001Date of Patent: April 20, 2004Assignee: Guilford Pharmaceuticals, Inc.Inventors: Jia-He Li, Vincent J. Kalish, Jie Zhang, Larisa E. Serdyuk, Dana Victor Ferraris, Ge Xiao, Paul W. Kletzly
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Publication number: 20040053923Abstract: This invention relates to compounds represented by the general formula [I] 1Type: ApplicationFiled: April 8, 2003Publication date: March 18, 2004Applicant: Banyu Pharmaceutical Co., Ltd.Inventors: Toshio Nagase, Tomoharu Iino, Yoshiyuki Sato, Teruyuki Nishimura, Jun-Ichi Eiki
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Publication number: 20040034223Abstract: The present invention relates to the preparation of synthons that are used to form modules that, in turn, are used to form two-dimensional close-packed planar arrays, referred to as nanomembranes. In a presently preferred embodiment, a nanomembrane herein constitutes a filter.Type: ApplicationFiled: February 7, 2002Publication date: February 19, 2004Applicant: CoValent Partners, LLC.Inventors: Timothy B. Karpishin, Josh Kriesel, Grant Merrill, Donald B. Bivin, Thomas H. Smith, Martin Stuart Edelstein
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Publication number: 20040034023Abstract: The invention concerns the use of aromatic compounds capable of binding with G-quadruplex structures to produce medicines with anti-telomerase effect. Said compounds correspond to formula (I) wherein: R1, R2 and R3, identical or different, represent a hydrogen atom, or a —CH2—NH—(CH2)n—X group, wherein n is an integer from 2 to 4, and X is selected among —NH2—, —N(CH3)2 radicals, a heterocyclic radical such as piperidyl, imidazolyl, morpholinyl radical, or an indole-type condensed heterocyclic radical, —Z represents CH or N, each compound comprising two nitrogen atoms in the Z positions. The invention is useful for producing anticancer medicines.Type: ApplicationFiled: July 15, 2003Publication date: February 19, 2004Inventors: Jean-Louis Mergny, Laurent Lacroix, Marie-Paule Teulade-Fichou, Jean-Pierre Vigneron, Jean-Marie Lehn, Claude Helene
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Publication number: 20030158191Abstract: The invention provides cannabinol derivatives and pharmaceutical preparations thereof.Type: ApplicationFiled: December 22, 2002Publication date: August 21, 2003Inventor: Craig R. Travis
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Patent number: 6608066Abstract: The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treating or prophylaxis of undesired thrombosis.Type: GrantFiled: October 27, 2000Date of Patent: August 19, 2003Assignee: Sunol Molecular CorporationInventors: Jin-An Jiao, Lawrence K. Luepschen, Esperanza L. Nieves, Hing C. Wong, Dean P. Taylor
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Publication number: 20030149069Abstract: The present invention provides methods for synthesizing novel tetrahydroquinoline derivatives that are useful for cancer chemotherapy and anti-viral applications. The present invention provides compounds useful for cancer chemotherapy and methods for the preparation of these compounds. The present invention also includes cancer chemotherapy methods.Type: ApplicationFiled: September 24, 2002Publication date: August 7, 2003Inventors: Chao-Jun Li, Jianheng Zhang
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Patent number: 6573379Abstract: The present invention relates to a method for preparing 5- and 6-halomethyl quinoxalines. The method comprises contacting a 5- or 6-methyl quinoxaline with a halogenating agent in the presence of a radical initiator in a solvent selected from the group consisting of fluorobenzene, difluorobenzenes, trifluorobenzenes, chlorobenzene, dichlorobenzenes, trichlorobenzenes, &agr;, &agr;, &agr;-trifluorotoluene and &agr;, &agr;, &agr;-trichlorotoluene. The invention also relates to preparing 6-bromomethyl quinoxaline with N-bromosuccinimide in the presence of a radical initiator in 1,2-dichloroethane. The method for halogenating benzylic methyl groups may also be employed to halogenate a wide variety of halomethyl heterocyclic compounds.Type: GrantFiled: September 19, 2002Date of Patent: June 3, 2003Assignee: Air Products and Chemicals, Inc.Inventor: Juan Jesus Burdeniuc
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Publication number: 20030096999Abstract: The invention provides polyflurinated aromatic or heterocyclic compounds comprising at least three ring sustitutents, at least one of which comprises a sulphurpentafluoride group and at least one of which comprises a labile group; methods for their preparation are also disclosed. Preferably, the compounds comprise either two sulphurpentafluoride groups or one sulphurpentafluoride group and one other polyflurinated group, such as a trifluoromethyl group. Said labile group preferably comprises an amino, bromo or nitro group. Said compounds are useful in the preparation of medicaments.Type: ApplicationFiled: November 15, 2002Publication date: May 22, 2003Inventors: Roy Dennis Bowden, Martin Paul Greenhall
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Patent number: 6562972Abstract: The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous alkaline suspension of a 5- or 6-halomethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.Type: GrantFiled: July 19, 2001Date of Patent: May 13, 2003Assignee: Air Products and Chemicals, Inc.Inventor: Juan Jesus Brudeniuc
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Patent number: 6538005Abstract: The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics.Type: GrantFiled: July 12, 2001Date of Patent: March 25, 2003Assignee: ALTANA Pharma AGInventor: Beate Gutterer
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Patent number: 6534518Abstract: Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics.Type: GrantFiled: July 12, 2001Date of Patent: March 18, 2003Assignee: Altana Pharma AGInventor: Beate Gutterer
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Patent number: 6534519Abstract: The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics.Type: GrantFiled: July 12, 2001Date of Patent: March 18, 2003Assignee: Altana Pharma AGInventor: Beate Gutterer
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Patent number: 6534135Abstract: The invention relates to a process of preparing a discotic liquid crystalline compound by intramolecular oxidative cyclisation of a diaryl compound in an organic solvent in the presence of a strong acid, characterized in that an oxidative agent comprising a chrom(VI)oxide derivative is used, to discotic liquid crystalline compounds obtainable from said process, to liquid crystalline media, (co)polymers or polymer networks with columnar phases comprising said discotic liquid crystalline compounds, and to the use of said discotic liquid crystalline compounds, liquid crystalline media or liquid crystalline (co)polymers with columnar phases for liquid crystal displays, optical elements like polarizers, compensators or colour filters, chemical sensors, charge transport materials, optical storage media, nonlinear optics, decorative pigments, adhesive or synthetic resins with anisotropic mechanical properties.Type: GrantFiled: September 14, 2000Date of Patent: March 18, 2003Assignee: Merck Patent GesellschaftInventor: Mohammed Cherkaoui
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Patent number: 6514988Abstract: A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, pplycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g.Type: GrantFiled: September 29, 2000Date of Patent: February 4, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuichi Furuya, Nobuo Choh, Koichi Kato, Shuji Hinuma
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Publication number: 20020192670Abstract: A compound represented by the formula 1, a salt, hydrate, solvate or stereoisomer thereof.Type: ApplicationFiled: January 11, 2002Publication date: December 19, 2002Applicant: TOSOH CORPORATIONInventors: Takumi Tokunaga, Takahiko Ishiguro, Ryuichi Horie
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Patent number: 6492517Abstract: The present invention relates to a method for preparing 5- and 6-halomethyl quinoxalines. The method comprises contacting a 5- or 6-methyl quinoxaline with a halogenating agent in the presence of a radical initiator in a solvent selected from the group consisting of fluorobenzene, difluorobenzenes, trifluorobenzenes, chlorobenzene, dichlorobenzenes, trichlorobenzenes, &agr;, &agr;, &agr;-trifluorotoluene and &agr;, &agr;, &agr;-trichlorotoluene. The method for halogenating benzylic methyl groups may also be employed to halogenate a wide variety of halomethyl heterocyclic compounds.Type: GrantFiled: July 19, 2001Date of Patent: December 10, 2002Assignee: Air Products and Chemicals, Inc.Inventor: Juan Jesus Burdeniuc
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Patent number: 6479505Abstract: Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics.Type: GrantFiled: July 12, 2001Date of Patent: November 12, 2002Assignee: Altana Pharma AGInventor: Beate Gutterer
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Patent number: 6476025Abstract: Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeuticsType: GrantFiled: July 12, 2001Date of Patent: November 5, 2002Assignee: Altana Pharma AGInventor: Beate Gutterer
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Patent number: 6476048Abstract: This invention provides a novel class of substituted 6(5H)phenanthridinone compounds. Pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable salt, hydrate, prodrug, or mixture thereof are also described.Type: GrantFiled: June 22, 2000Date of Patent: November 5, 2002Assignee: Inotek Pharamaceuticals CorporationInventors: Csaba Szabo, Prakash Jagtap, Garry Southan, Andrew Salzman
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Patent number: 6458950Abstract: A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R1 is hydrogen, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; A is an optionally substituted lower alkylene, an optionally substituted lower alkenylene or a single bond; B is an optionally substituted imino or a single bond; or A and B taken together may form a single bond; and D is a single bond or a group of the formula (a):Type: GrantFiled: August 3, 2000Date of Patent: October 1, 2002Assignee: Shionogi & Co., Ltd.Inventors: Yasuhiro Nishitani, Koji Ishikura
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Publication number: 20020115855Abstract: The instant invention discloses a process for the preparation of compounds of formula I 1Type: ApplicationFiled: July 5, 2001Publication date: August 22, 2002Inventors: Michele Gerster, Paul Dubs
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Publication number: 20020103169Abstract: Novel anticancer agents of the phenanthridine class having a specific mechanism of action and cancer therapy methods are described, including the novel chemical compounds and their therapeutic use thereof in humans.Type: ApplicationFiled: August 8, 2001Publication date: August 1, 2002Inventors: Patrick Mailliet, Jean-Francois Riou, Jean-Louis Mergny, Abdelazize Laoui
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Patent number: 6417358Abstract: Process for the preparation of compounds of formula (I), wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula (V), wherein the general symbols are as defined in claim 1, with carbon monoxide in the presence of a catalyst.Type: GrantFiled: December 22, 2000Date of Patent: July 9, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Michael Tinkl, Samuel Evans, Peter Nesvadba
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Publication number: 20020012917Abstract: A compound of the following formula:Type: ApplicationFiled: December 8, 2000Publication date: January 31, 2002Applicant: Fuji Photo Film Co., Ltd.Inventors: Yoshihiko Makino, Kazunobu Takahashi, Makoto Takagi, Shigeori Takenaka, Kenichi Yamashita
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Publication number: 20020006927Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.Type: ApplicationFiled: May 15, 2001Publication date: January 17, 2002Inventors: Jia-He Li, Vincent J. Kalish, Jie Zhang, Larisa E. Serdyuk, Dana Victor Ferraris, Ge Xiao, Paul W. Kletzly
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Patent number: 6248884Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.Type: GrantFiled: June 3, 1999Date of Patent: June 19, 2001Assignee: The Perkin-Elmer CorporationInventors: Joe Y. L. Lam, Scott C. Benson, Steven M. Menchen
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Patent number: 6214839Abstract: Compounds of formula I pharmaceutically acceptable salts thereof and compositions of either are useful for treating conditions amenable to treatment with a phosphodiesterase inhibitor type 4.Type: GrantFiled: January 24, 2000Date of Patent: April 10, 2001Assignee: Byk Gulden Lomberg Chemische Fabrik GmbHInventor: Beate Gutterer
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Patent number: 6187788Abstract: A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g.Type: GrantFiled: October 1, 1998Date of Patent: February 13, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuichi Furuya, Nobuo Choh, Koichi Kato, Shuji Hinuma
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Patent number: 6147088Abstract: There are disclosed compounds of formula (I) and pharmaceutical acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions.Type: GrantFiled: November 12, 1998Date of Patent: November 14, 2000Assignee: Merck & Co., Inc.Inventors: Mark Goulet, Eric E Allen, Matthew J. Wyvratt, Jr., Jinlong Jiang, Roy G. Smith, Thomas F Walsh, Yi Tien Yang, Jonathan R Young, Robert J. Devita
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Patent number: 6127378Abstract: Compounds of the formula I in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics.Type: GrantFiled: September 3, 1998Date of Patent: October 3, 2000Assignee: Byk Gulden Lomberg Chemische Fabrik GmbHInventor: Beate Gutterer
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Patent number: 6120703Abstract: 5-Fluorophenanthridine derivatives and their use in liquid-crystalline mixtures 6-Fluorophenanthridine derivatives of the formula (I) ##STR1## in which G is --CF.dbd.N--,E.sup.1, E.sup.2, E.sup.3, E.sup.4, E.sup.5 and E.sup.6 are identical or different and are --CH--, --CF-- or --N--and R.sup.1 (--A.sup.1 --M.sup.1).sub.a (--A.sup.2 --M.sup.2).sub.b, (M.sup.3 --A.sup.3 --).sub.c (M.sup.4 --A.sup.4 --).sub.d R.sup.2 denote mesogenic radicalsare suitable as components for liquid-crystalline mixtures, especially ferroelectric mixtures.Type: GrantFiled: August 30, 1999Date of Patent: September 19, 2000Assignee: Aventis Research & Technologies Deutschland GmbH & Co. KGInventors: Wolfgang Schmidt, Javier Manero
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Patent number: 6071929Abstract: The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula: ##STR1## wherein: A is arylR.sup.1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, R--CO-- or R--COO--, wherein R is lower alkyl;R.sup.2 is hydrogen, lower alkyl or cycloalkylR.sup.3 -R.sup.7 are independently hydrogen, lower alkyl, lower alkoxy, hydroxy orR.sup.3 and R.sup.4 taken together are --(CH.sub.2).sub.n -- orR.sup.6 and R.sup.7 taken together are --OCH.sub.2 O-- andn is 3 or 4,as well as pharmaceutically acceptable salts for the manufacture of medicaments for the control or treatment of diseases which represent therapeutic indications for NMDA receptor subtype specific blockers.Type: GrantFiled: May 26, 1999Date of Patent: June 6, 2000Assignee: Hoffman-La Roche Inc.Inventors: Alexander Alanine, Anne Bourson, Bernd Buttelmann, Gunther Fischer, Marie-Paule Heitz Neidhart, Vincent Mutel, Emmanuel Pinard, Stephan Rover, Gerhard Trube, Rene Wyler
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Patent number: 6054448Abstract: Compounds of the formula ##STR1## in which R.sup.1 is Y or Y--C.sub.1-6 alkyl, where Y is carboxy, tetrazolyl, --SO.sub.2 H, --SO.sub.3 H, --OSO.sub.3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' where R' is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or optionally substituted phenyl-C.sub.1-6 alkyl,and R.sup.2, R.sup.3, R.sup.4, X and Z are as defined in the specification, possess affinity for metabotropic glutamate receptors and are useful in the treatment of disorders of the central nervous system.Type: GrantFiled: October 17, 1997Date of Patent: April 25, 2000Assignee: Eli Lilly and Company LimitedInventors: Barry Peter Clark, John Richard Harris
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Patent number: 6015902Abstract: Intercalator compounds of formula I-T.sub.m as defined herein are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the DNA molecule and show reduced self-quenching, while providing superior transport kinetics. The compounds have been found to provide enhanced fluorescence when bound to a DNA molecule within a fluorescent flow cytometry environment which is about eight to ten times brighter in fluorescence than "bis" structure conventional intercalating agents and other known intercalating agents utilized in flow cytometry environment.Type: GrantFiled: October 21, 1996Date of Patent: January 18, 2000Assignee: Abbott LaboratoriesInventors: Christopher Bieniarz, Jeffrey Bruce Huff, Denis R. Henrard
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Patent number: 5925527Abstract: The present invention relates to novel tricyclic tetrahydroquinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, n, and Y have the meanings provided.Type: GrantFiled: February 5, 1997Date of Patent: July 20, 1999Assignee: Trega Biosciences, Inc.Inventors: Thomas K. Hayes, John S. Kiely
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Patent number: 5919928Abstract: A phenanthridine derivative metal complex of formula 1 having a large absorption in the near-infrared range and a reduced absorption in the visible range, which phenanthridine derivative metal complex is used in a transparent recording medium: ##STR1## where M is a metal atom, and X is a negative ion.Type: GrantFiled: September 18, 1997Date of Patent: July 6, 1999Assignee: Nippon Paper Industries, Co., Ltd.Inventors: Reiji Ohashi, Yukiko Ryu, Tomoaki Nagai, Hidetoshi Yoshioka
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Patent number: 5888422Abstract: Fluorinated phenanthrene derivatives of the formula (I) ##STR1## in which the symbols and indices have the following meanings: E.sup.1, E.sup.2, E.sup.3, E.sup.4, E.sup.5 and E.sup.6 are identical or different and are --N--, --CF-- or --CH--;G is --CF.sub.2 CF.sub.2 -- or --CF.dbd.CF--;R.sup.1 and R.sup.2 are, for example, alkyl or alkoxy;M.sup.1, M.sup.2, M.sup.3 and M.sup.4 are, for example, O, --CO--O--, --O--CO-- or a single bond;A.sup.1 and A.sup.2 are, for example, 1,4-phenylene or pyrimidine-2,5-diyl;m and n are zero or one, but in total are not more than one,are suitable as components of liquid-crystalline mixtures.Type: GrantFiled: December 31, 1997Date of Patent: March 30, 1999Assignee: Hoechst AktiengesellschaftInventors: Javier Manero, Rainer Wingen
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Patent number: 5859255Abstract: A method of fluorinating a heterocyclic organic compound comprises the step of reacting a heterocyclic compound with elemental fluorine in the presence of another halogen. The reaction may be conducted in the presence of a base.Type: GrantFiled: June 20, 1997Date of Patent: January 12, 1999Assignee: F2 Chemicals Ltd.Inventors: Richard Dickinson Chambers, Graham Sandford
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Patent number: 5849750Abstract: Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.Type: GrantFiled: March 5, 1997Date of Patent: December 15, 1998Assignee: California Institute of TechnologyInventor: Andrew Gordon Myers
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Patent number: 5843952Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.Type: GrantFiled: July 8, 1997Date of Patent: December 1, 1998Assignee: American Cyanamid CompanyInventors: Jay Donald Albright, Fuk-Wah Sum
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Patent number: 5702638Abstract: Phenanthridine derivatives, and their use in liquid-crystalline mixturesA ferroelectric liquid-crystal mixture containing one or more phenanthridine derivatives of the formula (I) ##STR1## E.sup.1 and E.sup.2 are identical or different and are --N--, --CF-- or --CH--;R.sup.1 and R.sup.2 are identical or different and are, for example, a straight-chain or branched alkyl radical having 1 to 20 carbon atoms;Q is --CH.sub.2 --O--, --CO--O-- or a single bond;M.sup.1 and M.sup.2 are identical or different and are --CO--O--, --O--CO--, --CH.sub.2 --O--, --O--CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --C.tbd.C--, or a single bond;A.sup.1 and A.sup.Type: GrantFiled: July 17, 1996Date of Patent: December 30, 1997Assignee: Hoechst AktiengesellschaftInventors: Rainer Wingen, Barbara Hornung
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Patent number: 5656426Abstract: Novel acridinium esters that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays (e.g., immunoassays and gene probe assays) with improved-sensitivity are disclosed. In addition, the synthesis of these esters and their use in assays for detecting an analyte is described. In particular, assays for testosterone and the Rubella virus are disclosed.Type: GrantFiled: April 8, 1994Date of Patent: August 12, 1997Assignee: Chiron Diagnostics CorporationInventors: Say-Jong Law, Chariklia Sotiriou-Leventis, Anand Natrajan, Qingping Jiang, Peter B. Connolly, John P. Kilroy, Constance R. McCudden, Stephen M. Tirrell
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Patent number: 5629007Abstract: A series of benzoquinolin-3-ones are pharmaceuticals effective in preventing the development of prostatic cancer, or preventing or treating the metastasis to bone of prostatic cancer.Type: GrantFiled: March 21, 1995Date of Patent: May 13, 1997Assignee: ELi Lilly and CompanyInventors: James E. Audia, Blake L. Neubauer
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Patent number: 5622958Abstract: A quinone imine enediyne possessing cytotoxic activity towards cancer cells having the general structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently the same or different and are H, Br, Cl, F, NH.sub.2, CO.sub.2 H, or OH or a linear or branched alkyl, etc.; wherein R.sub.4 is H, OH or a linear or branched alkoxy, linear or branched alkoxycarbonyl, etc.; wherein R.sub.5 is H, Br, Cl, F, O.dbd., OH or S--SR, or a linear or branched alkyl, etc.; wherein R.sub.6 is H, Br, Cl, F, CO.sub.2 H, OH or S--SR', or a linear or branched alkyl, etc; wherein R.sub.7 is H, OH or S--SR", or a linear or branched alkyl, linear or branched alkoxycarbonyl, linear or branched alkoxy or linear or branched hydroxyalkyl group; and wherein R, R' and R" are independently the same or different and are a linear or branched alkyl, linear or branched acyl or linear or branched alkoxyalkyl group.Type: GrantFiled: December 1, 1994Date of Patent: April 22, 1997Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Matthew D. Shair, Taeyoung Yoon, T.-C. Chou
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Patent number: 5621104Abstract: The present invention provides for the preparation of compounds,namely, 3-phenanthridinones and their derivatives and their unique ability to inhibit 5-alpha-reductase or their isozymes thereof in mammals enabling said compounds for treating hyperandrogenic conditions of acne, androgenic alopecia, male pattern baldness,female hirsutism,benign prostatic hyperplasia, prostatitis and prostatic cancer.Type: GrantFiled: September 15, 1995Date of Patent: April 15, 1997Assignee: Merck & Co., Inc.Inventors: Donald W. Graham, William K. Hagmann
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Patent number: 5605906Abstract: Disclosed are novel cannabinoid (CB2) receptor agonists, their compositions, and the methods of their preparation. The compounds are useful for lowering ocular intra ocular pressure, treating glaucoma, useful as antiinflammatory, immunosuppressive, analgesics agents, and as agents for treatment and prevention of emesis and nausea because of the activity on the cannabinoid receptor.Type: GrantFiled: March 24, 1995Date of Patent: February 25, 1997Assignee: Merck Frosst Canada, Inc.Inventor: Cheuk K. Lau
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Patent number: 5599932Abstract: Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the DNA molecule and show reduced self-quenching, while providing superior transport kinetics. The compounds have been found to provide enhanced fluorescence when bound to a DNA molecule within a fluorescent flow cytometry environment which is about eight to ten times brighter in fluorescence than "bis" structure conventional intercalating agents and other known intercalating agents utilized in flow cytometry environment.Type: GrantFiled: June 5, 1995Date of Patent: February 4, 1997Assignee: Abbott LaboratoriesInventors: Christopher Bieniarz, Jeffrey B. Huff, Denis R. Henrard
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Patent number: 5565570Abstract: Acridinium sulfonylamides and isomers, such as phenanthridinium sulfonylamides, may be employed in applications including chemiluminmescent immunoassays. Methods for synthesis of these compounds include contacting an amine with a sulfonylhalide to form a sulfonamide and acylating with an activated carboxylic acid of an acridine or isomer thereof. The N-sulfonyl-9-acridinium carboxamide and isomers may be conjugated to antigens, haptens, antibodies, and nucleic acids for use in chemiluminescent assays.Type: GrantFiled: May 16, 1995Date of Patent: October 15, 1996Assignee: Abbott LaboratoriesInventors: Phillip G. Mattingly, Larry G. Bennett
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Patent number: 5545739Abstract: Acridinium sulfonylamides and isomers, such as phenanthridinium sulfonylamides, may be employed in applications including chemiluminmescent immunoassays. Methods for synthesis of these compounds include contacting an amine with a sulfonylhalide to form a sulfonamide and acylating with an activated carboxylic acid of an acridine or isomer thereof. The N-sulfonyl-9-acridinium carboxamide and isomers may be conjugated to antigens, haptens, antibodies, and nucleic acids for use in chemiluminescent assays.Type: GrantFiled: May 16, 1995Date of Patent: August 13, 1996Assignee: Abbott LaboratoriesInventors: Phillip G. Mattingly, Larry G. Bennett