The Tricyclo Ring System Consists Of A Five-membered Carbocyclic Ring Ortho Fused To Both A Six-membered Carbocyclic Ring And The Six-membered Hetero Ring (e.g., Indenopyridines, Etc.) Patents (Class 546/111)
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Patent number: 11963949Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).Type: GrantFiled: March 1, 2021Date of Patent: April 23, 2024Assignee: UNM RAINFOREST INNOVATIONSInventors: Eric R. Prossnitz, Geetanjali Sharma, Matthias Barton, Matthias R. Meyer
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Patent number: 11342506Abstract: An organic electroluminescent element includes a light emitting layer containing a polycyclic aromatic compound represented by (1) or its multimer having plural structures represented by (1) and an anthracene-based compound represented by (3). In (1) and (3), rings A to C represent optionally substituted aryl rings or heteroaryl rings, X1 and X2 represent >O, >N—R, >C(—R)2, >S, or >Se, R in >N—R represents aryl etc., R in >C(—R)2 represents hydrogen etc., R in >N—R and/or R in >C(—R)2 may be bonded to ring A, B, and/or C via linking group or single bond, X's and Ar4's represent hydrogen or optionally substituted aryls, not all X's and Ar4's represent hydrogen simultaneously, and at least one hydrogen in compound represented by (1) or (3) may be substituted by halogen etc. In the light emitting layer, concentration of the polycyclic aromatic compound or its multimer changes from a positive electrode layer to a negative electrode layer.Type: GrantFiled: June 17, 2019Date of Patent: May 24, 2022Assignees: KWANSEI GAKUIN EDUCATIONAL FOUNDATION, SK MATERIALS JNC CO., LTD.Inventors: Takuji Hatakeyama, Yukihiro Fujita
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Publication number: 20150141651Abstract: This application relates methods of making compounds A and B: Compounds A and B are useful as intermediates for the preparation of pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.Type: ApplicationFiled: November 19, 2014Publication date: May 21, 2015Inventors: Jean-Nicolas DESROSIERS, Zhibin LI, Bo QU, Jolaine SAVOIE, Chris Hugh SENANAYAKE, Xudong WEI, Xingzhong ZENG
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Patent number: 8975405Abstract: Disclosed is a compound of formula (I) and salts thereof. Also disclosed are methods of making the compound of formula (I) and the use of the compound as an intermediate for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.Type: GrantFiled: December 13, 2013Date of Patent: March 10, 2015Assignee: Boehringer Ingelheim International GmbHInventors: Bo Qu, Anjan Saha, Jolaine Savoie, Xudong Wei, Nathan K. Yee
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Publication number: 20150060808Abstract: Provided are an indenopyridine-based compound and an organic light-emitting device including the same.Type: ApplicationFiled: August 12, 2014Publication date: March 5, 2015Inventors: Soung-Wook KIM, Myeong-Suk KIM, Jae-Hong KIM, Sam-Il KHO, Seung-Soo YOON
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Publication number: 20140353650Abstract: A compound represented by the following formula (1).Type: ApplicationFiled: December 5, 2012Publication date: December 4, 2014Applicant: Idemitsu Kosan Co., Ltd.Inventors: Takushi Shiomi, Ryohei Hashimoto, Hideaki Nagashima
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Patent number: 8871934Abstract: The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.Type: GrantFiled: November 5, 2012Date of Patent: October 28, 2014Assignee: Japan Tobacco Inc.Inventors: Takahisa Motomura, Hironobu Nagamori, Koichi Suzawa, Hirotsugu Ito, Toru Morita, Satoru Kobayashi, Hisashi Shinkai
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Publication number: 20140315889Abstract: The present invention relates to a novel hydroxamate derivatives, more specifically, to novel hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC), isomers thereof, pharmaceutically acceptable salts thereof, hydrates or solvates thereof, use for preparing pharmaceutical compositions, pharmaceutical compositions comprising the same, treatment method using said composition, and a preparing method of novel hydroxamate derivatives. The novel selective hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC) compositions can be used for treatment of inflammatory disease, rheumatoid arthritis, or degenerative disease.Type: ApplicationFiled: October 26, 2012Publication date: October 23, 2014Applicant: CHONG KUN DANG PHARMACEUTICAL CORP.Inventors: Yuntae Kim, Changsik Lee, Hyun-mo Yang, Hojin Choi, Jaeki Min, Soyoung Kim, Dal-Hyun Kim, Nina Ha, Jung-Min Kim, Hyojin Lim, Eunhee Ko
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Publication number: 20140249174Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.Type: ApplicationFiled: February 26, 2014Publication date: September 4, 2014Inventors: Matthias Eckhardt, Hans-Juergen Martin, Martin Schuehle, Sandra Sick, Bing Shiou Yang
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Patent number: 8735585Abstract: Disclosed is a compound of formula (I) and salts thereof. Also disclosed are methods of making the compound of formula (I) and the use of the compound as an intermediate for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.Type: GrantFiled: August 14, 2012Date of Patent: May 27, 2014Assignee: Boehringer Ingelheim International GmbHInventors: Bo Qu, Anjan Saha, Jolaine Savoie, Xudong Wei, Nathan K. Yee
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Publication number: 20140107343Abstract: Disclosed is a compound of formula (I) and salts thereof. Also disclosed are methods of making the compound of formula (I) and the use of the compound as an intermediate for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.Type: ApplicationFiled: December 13, 2013Publication date: April 17, 2014Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Bo QU, Anjan SAHA, Jolaine SAVOIE, Xudong WEI, Nathan K. YEE
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Patent number: 8686149Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.Type: GrantFiled: November 4, 2011Date of Patent: April 1, 2014Assignee: Boehringer-Ingelheim International GmbHInventors: Matthias Eckhardt, Hans-Juergen Martin, Martin Schuehle, Sandra Sick
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Publication number: 20140031544Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.Type: ApplicationFiled: June 20, 2013Publication date: January 30, 2014Applicants: Boehringer Ingelheim International GmbH, Vitae Pharmaceuticals, Inc.Inventors: Matthias Eckhardt, Frank Himmelsbach, Linghang Zhuang, Stefan Peters, Herbert Nar
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Publication number: 20130274283Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.Type: ApplicationFiled: February 11, 2013Publication date: October 17, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Richard A. GATTI, Liutao DU, Robert DAMOISEAUX, Chih-Hung LAI, Michael JUNG, Jin-Mo KU, Carmen BERTONI
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Publication number: 20130274240Abstract: The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.Type: ApplicationFiled: November 5, 2012Publication date: October 17, 2013Inventor: JAPAN TOBACCO INC.
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Publication number: 20130274473Abstract: The current invention relates to novel platinum(II) based organometallic materials. These materials show high emission quantum efficiencies and low self-quenching constant. Also provided are high efficiency, green to orange emitting organic light-emitting diode (OLED) that are fabricated using platinum(II) based organometallic materials as the light-emitting material. The organometallic materials of the invention are soluble in common solvents; therefore, solution process methods such as spin coating and printing can be used for device fabrication. The devices fabricated from these materials show low efficiency roll-off.Type: ApplicationFiled: April 11, 2013Publication date: October 17, 2013Applicant: The University of Hong KongInventors: Chi Ming CHE, Chi Fai KUI, Chi Chung KWOK
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Patent number: 8541113Abstract: A pyrene compound is provided. The pyrene compound is represented by Formula 1: wherein A1 and A2 are as defined in the specification. Further provided is an organic electroluminescent device using the pyrene compound. The organic electroluminescent device has high color purity of blue light and shows long life characteristics. Therefore, the organic electroluminescent device is suitable for use in displays and lighting systems.Type: GrantFiled: August 21, 2009Date of Patent: September 24, 2013Assignee: SFC Co., Ltd.Inventors: Jong-Tae Je, Se-jin Lee, Bo-Kyoung Song, Sang-Hae Lee, Jin-Woo Park
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Publication number: 20130211089Abstract: Disclosed is a compound of formula (I) and salts thereof. Also disclosed are methods of making the compound of formula (I) and the use of the compound as an intermediate for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.Type: ApplicationFiled: August 14, 2012Publication date: August 15, 2013Applicant: Boehringer Ingelheim International GmbHInventors: Bo QU, Anjan Saha, Jolaine Savoie, Xudong Wei
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Patent number: 8497281Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.Type: GrantFiled: November 5, 2010Date of Patent: July 30, 2013Assignees: Vitae Pharmaceuticals, Inc., Boehringer Ingelheim International GmbHInventors: Matthias Eckhardt, Stefan Peters, Herbert Nar, Frank Himmelsbach, Linghang Zhuang
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Publication number: 20130126857Abstract: A novel organic compound suitably used for a green-light-emitting device and an organic light-emitting device are provided. An organic light-emitting device and an image display apparatus containing a naphtho[2?,3?:5,6]indeno[1,2,3-cd]pyrene derivative represented by general formula (1) as a dopant: wherein in general formula (1), R1 to R16 are each independently selected from a hydrogen atom, a halogen atom, substituted or unsubstituted alkyl groups, substituted or unsubstituted alkoxy groups, substituted or unsubstituted amino groups, substituted or unsubstituted aryl groups, and substituted or unsubstituted heterocyclic groups, and at least one of R3, R4, R9, and R10 is selected from substituted or unsubstituted aryl groups and substituted or unsubstituted heterocyclic groups.Type: ApplicationFiled: July 26, 2011Publication date: May 23, 2013Applicant: CANON KABUSHIKI KAISHAInventors: Tomonari Horikiri, Jun Kamatani, Masanori Muratsubaki
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Publication number: 20130105767Abstract: In an embodiment, a carbazole derivative is provided. The carbazole derivative has formula (I): In formula (I), Ar1 and Ar2 are, independently, substituted or unsubstituted phenyl, naphthalenyl or heteroaryl containing nitrogen, oxygen or sulfur, and R is hydrogen, methyl or t-butyl. In another embodiment, an organic light emitting diode including the carbazole derivative is provided.Type: ApplicationFiled: April 16, 2012Publication date: May 2, 2013Inventors: Jin-Sheng LIN, Mei-Rurng TSENG, Miao-Tsai CHU
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Patent number: 8343994Abstract: The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.Type: GrantFiled: October 9, 2009Date of Patent: January 1, 2013Assignee: Japan Tobacco Inc.Inventors: Takahisa Motomura, Hironobu Nagamori, Koichi Suzawa, Hirotsugu Ito, Toru Morita, Satoru Kobayashi, Hisashi Shinkai
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Patent number: 8273762Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.Type: GrantFiled: June 2, 2010Date of Patent: September 25, 2012Assignee: Janssen Pharmaceutica NVInventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
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Publication number: 20120175599Abstract: [Problem] An organic compound of excellent characteristics is provided that exhibits excellent hole-injecting/transporting performance with electron blocking ability, and that has high stability in the thin-film state and high luminous efficiency, the organic compound being provided as material for an organic electroluminescent device having high efficiency and high durability. The invention also provides a high-efficient, high-durable organic electroluminescent device using the compound. [Means for Resolution] The compound is of the following general formula having a carbazole ring structure. The organic electroluminescent device includes a pair of electrodes, and one or more organic layers sandwiched between the pair of electrodes, and the compound is used as a constituent material of at least one organic layer.Type: ApplicationFiled: August 25, 2010Publication date: July 12, 2012Applicant: Hodogaya Chemical Co., Ltd.Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi, Shigeru Kusano
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Publication number: 20120157488Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.Type: ApplicationFiled: November 4, 2011Publication date: June 21, 2012Applicant: Boehringer-Ingelheim International GmbHInventors: Matthias Eckhardt, Hans-Juergen Martin, Martin Schuehle, Sandra Sick, Bing-Shiou Yang
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Patent number: 8110685Abstract: A novel azafluorene derivative and an organic light-emitting device having the derivative are provided. The organic light-emitting device includes a pair of electrodes composed of an anode and a cathode one of which is a transparent or semi-transparent electrode, and an organic compound layer interposed between the pair of electrodes.Type: GrantFiled: December 20, 2007Date of Patent: February 7, 2012Assignee: Canon Kabushiki KaishaInventors: Tetsuya Kosuge, Akihiro Senoo, Hiroki Ohrui, Masanori Muratsubaki
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Publication number: 20120025183Abstract: Provided is an acenaphtho[1,2-k]benzo[e]acephenanthrene derivative represented by general formula (1): wherein R1 to R16 are each independently selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group; and at least one of R1 to R8 and R10 to R15 is selected from a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group.Type: ApplicationFiled: April 22, 2010Publication date: February 2, 2012Applicant: CANON KABUSHIKI KAISHAInventors: Jun Kamatani, Takayuki Horiuchi, Naoki Yamada, Akihito Saitoh
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Publication number: 20120012824Abstract: Disclosed is a metal complex compound represented by the following Chemical Formula 1, and an organic light emitting diode device including the same. In Chemical Formula 1, M, R1 to R8, A1 to A6, and y are the same as defined in the detailed description.Type: ApplicationFiled: June 24, 2011Publication date: January 19, 2012Applicant: Samsung Mobile Display Co., Ltd.Inventors: Hamada Yuji, Kwan-Hee Lee
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Patent number: 8076348Abstract: [Problem] To provide a compound which can be used in the prevention and/or treatment of diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in the treatment of irritable bowel syndrome (IBS) and/or prevention of migraine. [Means for Resolution] It was found that an acylguanidine derivative having a tricyclic structure or a pharmaceutically acceptable salt thereof has a strong antagonism to 5-HT2B receptor and 5-HT7 receptor. In addition, the compound of the present invention having antagonism to both of the receptors showed superior pharmacological action in comparison with the case of the single use of an antagonist selective for either one of the receptors. Based on the above, the compound of the present invention is useful in preventing and/or treating diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in treating irritable bowel syndrome (IBS) and/or preventing migraine.Type: GrantFiled: August 7, 2006Date of Patent: December 13, 2011Assignee: Astellas Pharma Inc.Inventors: Hiroyoshi Yamada, Hirotsune Itahana, Ayako Moritomo, Takaho Matsuzawa, Eisuke Nozawa, Shinobu Akuzawa, Koichiro Harada
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Patent number: 8034944Abstract: There are provided a novel benzofluoranthene compound and an organic light-emitting device which uses the benzofluoranthene compound, gives a blue emission hue with extremely good purity, and has an optical output with a high efficiency, a high luminance, and a long life. Specifically, there are provided a benzofluoranthene compound represented by the general formula shown below and an organic light-emitting device including a pair of electrodes including an anode and a cathode one of which is a transparent or translucent electrode material, and an organic compound layer disposed between the pair of electrodes and including a material for an organic light-emitting device containing the benzofluoranthene compound. In the general formula (1), one of X1, X2, X3, X4, X5, and X6 represents a substituted or unsubstituted fused heterocyclic group having four or less rings, and the others of X1, X2, X3, X4, X5, and X6 each represent a hydrogen atom.Type: GrantFiled: December 12, 2007Date of Patent: October 11, 2011Assignee: Canon Kabushiki KaishaInventors: Hiroki Ohrui, Akihito Saitoh, Chika Negishi, Hironobu Iwawaki, Masanori Muratsubaki, Hiroyuki Tomono, Tetsuya Kosuge, Akihiro Senoo
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Publication number: 20110136800Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.Type: ApplicationFiled: November 5, 2010Publication date: June 9, 2011Inventors: Matthias Eckhardt, Stefan Peters, Herbert Nar, Frank Himmelsbach, Linghang Zhuang
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Publication number: 20110112098Abstract: The present invention relates to the C-13 molecule (methyl 2-{5-[(3-benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}-benzoate) and to organic molecules functionally equivalent to the C-13 molecule, capable of inhibiting the binding of an antibody or antibody fragment with the human Syk protein tyrosine kinase, to the use of these molecules for the production of medicaments for the prevention or treatment of diseases dependent on metabolic pathways involving Syk, and also to a method for identifying such molecules.Type: ApplicationFiled: April 8, 2009Publication date: May 12, 2011Inventors: Piona Dariavach, Pierre Emile Ulysse Martineau, Bruno Villoutreix
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Publication number: 20110028445Abstract: The present invention relates to compounds defined by formula (I) wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 ?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.Type: ApplicationFiled: February 10, 2009Publication date: February 3, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Matthias Eckhardt, Frank Himmelsbach, Bradford S. Hamilton, Stefan Peters
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Publication number: 20100267695Abstract: [Problems] To provide a compound which is useful as an NMDA receptor antagonist. [Means for Solution] The present inventors have studied a compound having an NMDA receptor antagonistic action, and confirmed that the fused indane compound of the present invention has an excellent NMDA receptor antagonistic action, thereby completed the present invention. The fused indane compound of the present invention has an excellent NMDA receptor antagonistic action and can be used as a prophylactic and/or therapeutic agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, intractable depression, attention deficit hyperactivity disorder, migraines, or the like.Type: ApplicationFiled: November 26, 2008Publication date: October 21, 2010Applicant: ASTELLAS PHARMA INC.Inventors: Satoshi Hayashibe, Shingo Yamasaki, Nobuyuki Shiraishi, Hiroaki Hoshii, Takahiko Tobe
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Publication number: 20100240634Abstract: The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.Type: ApplicationFiled: October 9, 2009Publication date: September 23, 2010Applicant: JAPAN TOBACCO INC.Inventors: Takahisa Motomura, Hironobu Nagamori, Koichi Suzawa, Hirotsugu Ito, Toru Morita, Satoru Kobayashi, Hisashi Shinkai
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Publication number: 20100168096Abstract: [Problem] To provide a compound which can be used in the prevention and/or treatment of diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in the treatment of irritable bowel syndrome (IBS) and/or prevention of migraine. [Means for Resolution] It was found that an acylguanidine derivative having a tricyclic structure or a pharmaceutically acceptable salt thereof has a strong antagonism to 5-HT2B receptor and 5-HT7 receptor. In addition, the compound of the present invention having antagonism to both of the receptors showed superior pharmacological action in comparison with the case of the single use of an antagonist selective for either one of the receptors. Based on the above, the compound of the present invention is useful in preventing and/or treating diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in treating irritable bowel syndrome (IBS) and/or preventing migraine.Type: ApplicationFiled: August 7, 2006Publication date: July 1, 2010Inventors: Hiroyoshi Yamada, Hirotsune Itahana, Ayako Moritomo, Takaho Matsuzawa, Eisuke Nozawa, Shinobu Akuzawa, Koichiro Harada
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Publication number: 20100127618Abstract: There is provided an organic light-emitting device having an optical output with a high efficiency, a high luminance, and a long life.Type: ApplicationFiled: May 16, 2008Publication date: May 27, 2010Applicant: CANON KABUSHIKI KAISHAInventors: Hiroki Ohrui, Akihito Saitoh, Chika Negishi, Hironobu Iwawaki, Masanori Muratsubaki, Shinjiro Okada
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Publication number: 20100052526Abstract: A pyrene compound is provided. The pyrene compound is represented by Formula 1: wherein A1 and A2 are as defined in the specification. Further provided is an organic electroluminescent device using the pyrene compound. The organic electroluminescent device has high color purity of blue light and shows long life characteristics. Therefore, the organic electroluminescent device is suitable for use in displays and lighting systems.Type: ApplicationFiled: August 21, 2009Publication date: March 4, 2010Inventors: Jong-Tae Je, Se-jin Lee, Bo-Kyoung Song, Sang-Hae Lee, Jin-Woo Park
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Publication number: 20090278118Abstract: There are provided a novel benzofluoranthene compound and an organic light-emitting device which uses the benzofluoranthene compound, gives a blue emission hue with extremely good purity, and has an optical output with a high efficiency, a high luminance, and a long life. Specifically, there are provided a benzofluoranthene compound represented by the general formula shown below and an organic light-emitting device including a pair of electrodes including an anode and a cathode one of which is a transparent or translucent electrode material, and an organic compound layer disposed between the pair of electrodes and including a material for an organic light-emitting device containing the benzofluoranthene compound. In the general formula (1), one of X1, X2, X3, X4, X5, and X6 represents a substituted or unsubstituted fused heterocyclic group having four or less rings, and the others of X1, X2, X3, X4, X5, and X6 each represent a hydrogen atom.Type: ApplicationFiled: December 12, 2007Publication date: November 12, 2009Applicant: CANON KABUSHIKI KAISHAInventors: Hiroki Ohrui, Akihito Saitoh, Chika Negishi, Hironobu Iwawaki, Masanori Muratsubaki, Hiroyuki Tomono, Tetsuya Kosuge, Akihiro Senoo
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Publication number: 20090238760Abstract: Hexahydroindenopyridine compounds are disclosed which act as contraceptive agents by disrupting spermatogenesis, acting as spermicides or sperm motility inhibitors and/or act as antifungals; antispermatogenic, sperm motility inhibitors, spermicidal or antifungal compositions containing the compounds; and methods for disrupting spermatogenesis, inhibiting sperm motility, killing motile sperm or treating fungi using the compounds and compositions. Also disclosed are radioactive compounds which may be used to study the binding of antifertility compounds to specific sites in the body and the use of such compounds for that purpose.Type: ApplicationFiled: April 19, 2007Publication date: September 24, 2009Applicant: Research Triangle InstituteInventors: Clarence Edgar Cook, Kevin M Cook, Clyde Ray Tallent, Brian Frazier Thomas, Hernan Andres Navarro
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Patent number: 7544696Abstract: Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions.Type: GrantFiled: January 24, 2003Date of Patent: June 9, 2009Assignee: Research Triangle InstituteInventors: Clarence Edgar Cook, Carol Delta Sloan, Brian Frazier Thomas, Hernan Andres Navarro
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Publication number: 20090137558Abstract: The present invention relates to substituted pyridine compounds of Formula (I) and derivatives thereof, and to a process for preparing these substituted pyridines. The invention also relates to the use of the substituted pyridines as intermediates in the production of pharmaceutical, chemical and agro-chemical products.Type: ApplicationFiled: December 1, 2005Publication date: May 28, 2009Applicant: PEAKDALE MOLECULAR LIMITEDInventors: Raymond Fisher, Andrew Lund
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Publication number: 20090118267Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.Type: ApplicationFiled: February 13, 2006Publication date: May 7, 2009Inventors: Dirk Finsinger, David Bruge, Hans-Peter Buchstaller, Ulrich Emde, Kai Schiemann, Wolfgang Staehle, Christiane Amendt, Nina Heiss, Frank Zenke
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Patent number: 7528144Abstract: The present invention provides molecules and methods for fluorescent microscopy and visualization of biomolecules, such as cholesterol. In a preferred embodiment, the present invention provides a compound having the structure: wherein R1 and R2 are selected from the group consisting of H, CnH2n+1, (CH2)mNH2, (CH2)mNH—SO2—R?, and CH2CH2OCH2CH2NH2 wherein n has a value between 4 and 18, wherein m has a value between 2 and 8, and wherein R? is selected from the group consisting of CH3, C6H5, C6H4CH3, C6H4CO2H and its cyclic imide, C6H4Br, anthraquinon-2-yl, and 5-formyl-2-furyl, 2-carboxyphenyl.Type: GrantFiled: March 14, 2005Date of Patent: May 5, 2009Assignee: WiSys Technology Foundation, Inc.Inventors: Scott C. Hartsel, David E. Lewis
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Publication number: 20090054429Abstract: This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant compounds and pharmaceutical compositions.Type: ApplicationFiled: October 23, 2008Publication date: February 26, 2009Inventors: Geoffrey R. Heintzelman, James Lawrence Bullington, Kenneth C. Rupert
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Publication number: 20080318996Abstract: The present invention relates to 6-amino(aza)indane compound of the formula (I) Wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R6 and wherein Ar may also carry I or 2 radicals Rb; X is N or CH; E is CR6R7 or NR3; R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl; R1a is H or R1a and R2 or R1a and R2a together are (CH2)n with n being 1, 2, 3 or 4; R2 and R2a each independently are H, CH3, CH2F, CHF2 or CF3; R3 is H or C,-C4-alkyl; and the physiologically tolerated acid addition salts of these compounds.Type: ApplicationFiled: October 14, 2005Publication date: December 25, 2008Inventors: Karla Drescher, Andreas Haupt, Liliane Unger, Sean C. Turner, Wilfried Braje, Roland Grandel
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Publication number: 20080154040Abstract: A novel azafluorene derivative and an organic light-emitting device having the derivative are provided. The organic light-emitting device includes a pair of electrodes composed of an anode and a cathode one of which is a transparent or semi-transparent electrode, and an organic compound layer interposed between the pair of electrodes.Type: ApplicationFiled: December 20, 2007Publication date: June 26, 2008Applicant: CANON KABUSHIKI KAISHAInventors: Tetsuya Kosuge, Akihiro Senoo, Hiroki Ohrui, Masanori Muratsubaki
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Patent number: 7351711Abstract: The present invention is directed to substituted indanyl compounds of Formula (I): Useful for treating integrin-mediated disorders such as, but not limited to unstable angina, thromboemboic disorders, osteoporosis, growth and metastasis of malignant tumors, diabetic retinopathy, arthritis, viral disease and surgical adhesions.Type: GrantFiled: July 28, 2004Date of Patent: April 1, 2008Assignee: Janssen Pharmaceutical, N.V.Inventors: William A. Kinney, Diane K. Luci, Bruce E. Maryanoff
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Patent number: 7345052Abstract: This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant compounds and pharmaceutical compositions.Type: GrantFiled: June 29, 2005Date of Patent: March 18, 2008Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Geoffrey R. Heintzelman, James Lawrence Bullington, Kenneth C. Rupert
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Patent number: 7241810Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.Type: GrantFiled: March 21, 2005Date of Patent: July 10, 2007Assignee: Pfizer IncInventors: Alan Daniel Brown, Mark Edward Bunnage, Charlotte Alice Louise Lane, Russell Andrew Lewthwaite, Paul Alan Glossop, Kim James, David Anthony Price