Plural Chalcogens Attached Directly To The Six-membered Hetero Ring By Nonionic Bonding Patents (Class 546/155)
-
Publication number: 20080026478Abstract: Coumarine/chinolone and Martina-type compounds, compositions, and method of using the compounds and compositions for protein detection, assay, quantitation, etc. are disclosed. The composition, also referred to as a dye, has enhanced sensitivity over commercially available protein stains, and may be used to stain proteins in solution, proteins separated on gels, proteins transferred to solid supports, etc.Type: ApplicationFiled: July 28, 2006Publication date: January 31, 2008Applicant: PIERCE BIOTECHNOLOGY, INC.Inventors: Peter T. Czerney, Surbhi Desai, Frank G. Lehmann, Zakir S. Murtaza, Bernd G. Schweder, Matthias S. Wenzel, Brian David Wolf
-
Patent number: 7253286Abstract: Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—, Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.Type: GrantFiled: April 18, 2003Date of Patent: August 7, 2007Assignee: Eisai Co., LtdInventors: Yasuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken-ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui, Kenji Matsui, Takako Yoshiba, Yasuyuki Suzuki, Itaru Arimoto
-
Patent number: 7220861Abstract: Provided is a process for preparing quinolonecarboxylate derivatives under a mild condition in high yield, so as to be favorably applied to a large-scale mass production thereof.Type: GrantFiled: December 19, 2003Date of Patent: May 22, 2007Assignee: Yuhan CorporationInventors: Tai Au Lee, Nam Jin Park, Ja Heouk Khoo, Seong Ho Song, Ju Young An
-
Patent number: 7179920Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndromeType: GrantFiled: October 13, 2004Date of Patent: February 20, 2007Assignee: Bristol-Myers Squibb CompanyInventors: Kenneth M. Boy, Piyasena Hewawasam, Sing-Yuen Sit
-
Patent number: 7176314Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.Type: GrantFiled: December 4, 2002Date of Patent: February 13, 2007Assignee: Amgen, Inc.Inventors: Timothy D. Cushing, Xiao He, Marie-Louise Smith, Michael R. DeGraffenreid, Jay Powers, Craig S. Tomooka, David L. Clark, Xiaolin Hao, Juan C. Jaen, Marc Labelle, Nigel P. C. Walker, Adrian L. Gill, Francisco X. Talamas, Sharada Labadie
-
Patent number: 7151180Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.Type: GrantFiled: October 13, 2004Date of Patent: December 19, 2006Assignee: Bristol-Myers Squibb CompanyInventors: Piyasena Hewawasam, Sing-Yuen Sit, John E. Starrett, Jr.
-
Patent number: 7132542Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.Type: GrantFiled: October 13, 2004Date of Patent: November 7, 2006Assignee: Bristol-Myers Squibb CompanyInventor: Kenneth M. Boy
-
Patent number: 7071201Abstract: A novel compound of the formula: wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R1, R2, R3, R4, and R5 represent each a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3; and pharmacologically acceptable salts thereof. The compound has a serotonin antagonism and is clinically useful as medicament, in particular, for treating, ameliorating and preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.Type: GrantFiled: May 2, 2001Date of Patent: July 4, 2006Assignee: Eisai Co., Ltd.Inventors: Noritaka Kitazawa, Kohshi Ueno, Keiko Takahashi, Teiji Kimura, Atsushi Sasaki, Koki Kawano, Tadashi Okabe, Makoto Komatsu, Manabu Matsunaga, Atsuhiko Kubota
-
Patent number: 7056917Abstract: A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W1 represents —CH?CH—, —CH2O—, —CH2CH2— or the like; R3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R4 represents hydrogen atom, a group of —OZ0-4R5 (Z0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R5 represents a cyclic alkyl group, an aryl group or the like); W2 represents a single bond or —C(R8)?C(R9)— (R8 and R9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.Type: GrantFiled: April 26, 2001Date of Patent: June 6, 2006Assignees: Daiichi Pharmaceutical Co., Ltd., Trine Pharmaceuticals, Inc.Inventors: Kiyoshi Nakayama, Masami Ohtsuka, Haruko Kawato, William Watkins, Jason Zhang, Monica Palme, Aesop Cho
-
Patent number: 7045627Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.Type: GrantFiled: May 17, 2005Date of Patent: May 16, 2006Assignee: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 7034040Abstract: Compositions of the present invention comprise fluorinated heterocyclic compounds, including monofluoroflosequinan and difluoroflosequinan. The methods of the present invention comprise the synthesis of monofluoroflosequinan and difluoroflosequinan.Type: GrantFiled: May 20, 2004Date of Patent: April 25, 2006Assignee: R.T. Alamo Ventures IInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 7019139Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.Type: GrantFiled: November 17, 2003Date of Patent: March 28, 2006Assignee: ARIAD Pharmaceuticals, Inc.Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
-
Patent number: 7002015Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.Type: GrantFiled: October 13, 2004Date of Patent: February 21, 2006Assignee: Bristol-Myers Squibb CompanyInventor: Kenneth M. Boy
-
Patent number: 6964973Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.Type: GrantFiled: November 18, 2002Date of Patent: November 15, 2005Assignee: Ligand Pharmaceuticals IncorporatedInventors: Lin Zhi, Barbara Pio, Luc Farmer
-
Patent number: 6951870Abstract: Compounds of formula I? wherein the two —OH substituents in the phenyl moiety are in a position ortho to one another and R1 in a position ortho to one of the hydroxy groups; and X, R1 to R6 are as defined in disclosure. The compounds exhibit COMT enzyme inhibiting activity, so are useful as COMT inhibitors.Type: GrantFiled: June 28, 2001Date of Patent: October 4, 2005Assignee: Orion CorporationInventors: Jarmo Pystynen, Martti Ovaska, Jukka Vidgren, Timo Lotta, Marjo Yliperttula-Ikonen
-
Patent number: 6933388Abstract: There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4-quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula: wherein R is alkyl(C1-C3) prepared by reacting a substituted anthranilate with N,N-dimethylformamide dimethyacetal to obtain a N,N-dimethylamidine which is condensed with t-butylcyanoacetate to obtain a N-(2-cyano-2-t-butoxycarbonylvinyl)anthranilate, which is hydrolyzed to yield a N-(2-cyano-2-carboxyvinyl)anthranilate followed by decarboxylating to obtain a N-(2-cyano-2-carboxyvinyl)anthranilate followed by cyclizing to obtain a 3-cyano-6-alkoxy-7-nitro-4-quinolone.Type: GrantFiled: April 7, 2004Date of Patent: August 23, 2005Assignee: Wyeth Holdings CorporationInventors: Scott Mason Duncan, Miguel Angel Pagan, Middleton Brawner Floyd, Jr.
-
Patent number: 6894166Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.Type: GrantFiled: February 18, 2004Date of Patent: May 17, 2005Assignee: R.T. Alamo Ventures IInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6875869Abstract: A process for the preparation of the compounds of general formula (I) wherein R is selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.Type: GrantFiled: June 12, 2003Date of Patent: April 5, 2005Assignee: Active Biotech ABInventor: Karl Jansson
-
Patent number: 6872831Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.Type: GrantFiled: December 31, 2003Date of Patent: March 29, 2005Assignee: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6861528Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.Type: GrantFiled: December 31, 2003Date of Patent: March 1, 2005Assignee: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6852734Abstract: According to this invention, there is provided an indole derivative having the general formula (I) wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) R1 and R2 each stand for a hydrogen atom or an alkyl group, independently, or (ii) R1 and R2 as taken together form a cycloalkyl group or an aromatic ring, or (iii) R1 and R2 as taken together form a heterocyclic ring, and R3 is a hydrogen atom, a (C1-C10)alkyl group or others, R4 is a substituted alkyl group and R5 is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity.Type: GrantFiled: May 1, 2001Date of Patent: February 8, 2005Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yasuo Yamamoto, Kenzo Hariyama, Yumiko Yanagisawa, Sojiro Shiokawa, Takumi Takeyasu, Osami Takenouchi, Hidenori Kasai
-
Patent number: 6844439Abstract: A process for the preparation of 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone which comprises reacting 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone with a C6-8alkyllithium compound, 1-methylimidazole and a tri(C4-6alkyl)silyl halide to obtain better yields of the above product.Type: GrantFiled: March 5, 2002Date of Patent: January 18, 2005Assignee: Jansen Pharmaceutica, NVInventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx, Stefan Marcel Herman Leurs
-
Patent number: 6838527Abstract: As an ?-iminoester derivative that is stable under normal conditions and a method of producing various ?-aminoester derivatives using them, a polymer-immobilized ?-iminoester derivative represented by the following general formula (1): wherein R1 represents an alkyl chain of 1 or more carbons, and R2 represents a hydrogen atom, halogen atom, or an alkyl group, aryl group or alkoxy group that may contain substituents, and a method of producing an ?-iminoester derivative using them are provided.Type: GrantFiled: March 13, 2001Date of Patent: January 4, 2005Assignee: Japan Science and Technology CorporationInventor: Shu Kobayashi
-
Patent number: 6835836Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.Type: GrantFiled: February 18, 2004Date of Patent: December 28, 2004Assignee: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6833370Abstract: Heterocyclic substituted aminoazacyclic compounds of formula I Z—R3 I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.Type: GrantFiled: April 26, 2000Date of Patent: December 21, 2004Assignee: Abbott LaboratoriesInventors: Michael R. Schrimpf, Kevin B. Sippy, Jerome F. Daanen, Keith Brian Ryther, Jianguo Ji
-
Patent number: 6833378Abstract: Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.Type: GrantFiled: January 17, 2001Date of Patent: December 21, 2004Assignee: Pfizer IncInventor: Yuhpyng L. Chen
-
Publication number: 20040242630Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.Type: ApplicationFiled: February 18, 2004Publication date: December 2, 2004Applicant: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Preparation and use of ortho-sulfonamido arylhydroxamic acids as matrix metalloproteinase inhibitors
Patent number: 6825352Abstract: Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.Type: GrantFiled: August 30, 2002Date of Patent: November 30, 2004Assignee: WyethInventors: Frances Christy Nelson, Arie Zask, James Ming Chen, Dominick Mobilio, Ramaswamy Nilakantan -
Patent number: 6822098Abstract: An ester or amide derivative represented by the general formula (I) or a pharmaceutically acceptable salt thereof. Particularly, an ester or amide derivative of 4-oxo-1,4-dihydroqunoline-2-carboxylic acid represented by the general formula (I′) or (I″), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 28, 2003Date of Patent: November 23, 2004Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Jun-ichi Kazami, Masato Watanabe, Takuya Hirata
-
Patent number: 6822097Abstract: Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.Type: GrantFiled: February 6, 2003Date of Patent: November 23, 2004Assignee: Amgen, Inc.Inventors: Mark H. Norman, Hui-Ling Wang, Robert Rzasa, Wenge Zhong, Thomas Nguyen, Matthew Kaller, Hu Liu
-
Publication number: 20040229906Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.Type: ApplicationFiled: February 18, 2004Publication date: November 18, 2004Applicant: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6806371Abstract: A process for preparing substituted pyridine N-oxide compounds of the formula in which R1, R2, R3 and R4 are each H, a carboxyl group or a C1-C12-alkyl radical which may contain atoms from the group of N, O and S, or R1 and R2 and/or R3 and R4 together may each form an optionally substituted C4-C20-alkylene radical which may contain atoms from the group of N, O and S, A is benzyl or a (CH2)m group where m may be an integer from 1 to 12, Z1 and Z2 are each independently O or S, and Y is H, a C1-C12-alkyl radical which may optionally contain atoms from the group of N, O and S, a C6-C20-aryl radical or a C5-C20-heterocycle, and the radicals may optionally be substituted, or Z2 and Y together form an optionally substituted ring or ring system, in which case the ring or ring system may contain atoms from the group of N, O and S, from the corresponding 4-halopyridine N-oxide of the formula in which X is chlorine, bromine or iodine, by reacting the compound of the formula (II)Type: GrantFiled: October 1, 2003Date of Patent: October 19, 2004Assignee: DSM Fine Chemicals Austria Nfg GmbH & Co KGInventors: Thomas Zich, Wolfgang Schiek, Markus Rössler, Christian Seifter
-
Patent number: 6806276Abstract: A 2-oxoquinoline compound or its pharmaceutically acceptable salt of general formula [I]: (wherein each symbol in the formula is as determined in the description), and its pharmaceutical use. The compound [I] of the present invention and its pharmaceutically acceptable salts selectively act on cannabinoid receptors, particularly on peripheral type cannabinoid receptors, and have fewer side effects on the central nervous system, having great immunosuppressive action, anti-inflammatory action or antiallergic action. Therefore, these compounds are useful as cannabinoid receptors (particularly peripheral type cannabinoid receptors) modulator, immunosuppressants, anti-inflammatory agents, and antiallergic agents.Type: GrantFiled: September 16, 2002Date of Patent: October 19, 2004Assignee: Japan Tobacco Inc.Inventors: Takashi Inaba, Tetsudo Kaya, Hiroyuki Iwamura
-
Patent number: 6777427Abstract: Tetrahydroquinoline compounds of general formula (I) or pharmacologically acceptable salts thereof, which have a specific and strong binding affinity for AR, exhibit AR agonism or antagonism, have therapeutic effects on AR-mediated diseases, particularly by not acting excessively on the prostate as AR agonists, but by showing potent action on skeletal muscle tissue and bone tissue; and pharmaceutical compositions comprising the compounds or the salts as active ingredients:Type: GrantFiled: March 13, 2003Date of Patent: August 17, 2004Assignee: Kaken Pharmaceutical Co., Ltd.Inventors: Motonori Miyakawa, Seiji Amano, Misa Kamei, Keigo Hanada, Kazuyuki Furuya, Noriko Yamamoto
-
Patent number: 6774134Abstract: The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatment of respiratory syncytial virus infection.Type: GrantFiled: November 16, 2001Date of Patent: August 10, 2004Assignee: Bristol-Myers Squibb CompanyInventors: Kuo-Long Yu, Rita L. Civiello, Keith D. Combrink, Hatice Belgin Gulgeze, Ny Sin, Xiangdong Wang, Nicholas Meanwell, Brian Lee Venables, Yi Zhang, Bradley C. Pearce, Zhiwei Yin, Jan Willem Thuring
-
Patent number: 6767914Abstract: Compositions of the present invention comprise fluorinated heterocyclic compounds, including monofluoroflosequinan and difluoroflosequinan. The methods of the present invention comprise the synthesis of monofluoroflosequinan and difluoroflosequinan.Type: GrantFiled: October 28, 2002Date of Patent: July 27, 2004Assignee: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6730790Abstract: Compositions of the present invention comprise chlorinated heterocyclic compounds, including racemic monochloroflosequinan, purified enantiomers of monochloroflosequinan and the sulfone derivative of monochloroflosequinan. The methods of the present invention comprise the synthesis of racemic monochloroflosequinan and derivatives thereof, including the sulfone derivative. Intermediates in the synthesis are also provided. The methods further comprise the synthesis of enantiomers of monochloroflosequinan.Type: GrantFiled: October 28, 2002Date of Patent: May 4, 2004Assignee: R.T. Alamo Ventures I. LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6727262Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.Type: GrantFiled: October 28, 2002Date of Patent: April 27, 2004Assignee: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6713462Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.Type: GrantFiled: June 21, 2002Date of Patent: March 30, 2004Assignee: Ariad Pharmaceuticals, Inc.Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
-
Patent number: 6699992Abstract: The present invention provides a process for preparing quinolonecarboxylic acid derivatives having the formula (I): wherein R1 is H, halogen, or amino; R2 is halogen; R3 is H, halogen, C1-4 alkoxyl, or CN; R4 is selected from the group consisting of C3-6cycloalkyl, C1-4alkyl, C1-4alkoxyC1-4alkyl, and C1-4alkylaminoC1-4alkyl. The invention also provides new acetophenones having the formula (II) that are intermediates for preparing the compound of the formula (I).Type: GrantFiled: February 12, 2003Date of Patent: March 2, 2004Assignee: Lynchem Co., Ltd.Inventors: Yuncai Wang, Rongye Chen, Haijun Nan
-
Publication number: 20040034227Abstract: A process for the preparation of the compounds of general formula (I) 1Type: ApplicationFiled: June 12, 2003Publication date: February 19, 2004Applicant: ACTIVE BIOTECH ABInventor: Karl Jansson
-
Patent number: 6689791Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.Type: GrantFiled: October 28, 2002Date of Patent: February 10, 2004Assignee: R. T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: 6686376Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).Type: GrantFiled: December 4, 2002Date of Patent: February 3, 2004Assignee: Eli Lilly and CompanyInventors: Rosanne Bonjouklian, Jeremy Schulenburg York
-
Publication number: 20030232854Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).Type: ApplicationFiled: December 4, 2002Publication date: December 18, 2003Inventors: Rosanne Bonjuklian, Jeremy York
-
Publication number: 20030176703Abstract: A process for preparing 6-hydroxy-3,4-dihydroquinolinone by intramolecular Friedel-Crafts alkylation of N-(4-methoxyphenyl)-3-chloropropionamide in which an equivalent of N-(4-methoxyphenyl)-3-chloropropionamide is contacted with a Lewis acid in DMSO or a high boiling amide or amine at an elevated temperature of from about 150° C. to about 220° C. is provided. The process produces 6-HQ in high yield and a high state of purity such that it may be used in subsequent reactions toward the preparation of cilostazol without intermediate purification. A process for preparing cilostazol from 6-hydroxy-3,4-dihydroquinolinone prepared by the process and improved processes for preparing N-(4-methoxyphenyl)-3-chloropropionamide are also provided.Type: ApplicationFiled: February 25, 2003Publication date: September 18, 2003Inventors: Marioara Mendelovici, Gideon Pilarsky, Tamar Nidam, Ben-Zion Dolitzky
-
Publication number: 20030166679Abstract: Compositions of the present invention comprise fluorinated heterocyclic compounds, including monofluoroflosequinan and difluoroflosequinan. The methods of the present invention comprise the synthesis of monofluoroflosequinan and difluoroflosequinan.Type: ApplicationFiled: October 28, 2002Publication date: September 4, 2003Applicant: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Publication number: 20030166678Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.Type: ApplicationFiled: October 28, 2002Publication date: September 4, 2003Applicant: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Publication number: 20030166676Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.Type: ApplicationFiled: October 28, 2002Publication date: September 4, 2003Applicant: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Publication number: 20030166677Abstract: Compositions of the present invention comprise chlorinated heterocyclic compounds, including racemic monochloroflosequinan, purified enantiomers of monochloroflosequinan and the sulfone derivative of monochloroflosequinan. The methods of the present invention comprise the synthesis of racemic monochloroflosequinan and derivatives thereof, including the sulfone derivative. Intermediates in the synthesis are also provided. The methods further comprise the synthesis of enantiomers of monochloroflosequinan.Type: ApplicationFiled: October 28, 2002Publication date: September 4, 2003Applicant: R.T. Alamo Ventures I, LLCInventors: Stefan Kwiatkowski, Miroslaw Golinski
-
Patent number: RE39265Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: November 9, 2000Date of Patent: September 5, 2006Assignee: Aventis Pharmaceuticals Inc.Inventors: Joseph T. Strupczewski, Kenneth J. Bordeau, Edward J. Glamkowski, Yulin Chiang, Grover C. Helsley