Acyclic Nitrogen Bonded Directly To The -c(=x)- Group Patents (Class 546/169)
  • Patent number: 4252957
    Abstract: Heterocyclylcarbonyl derivatives of urea having the formula ##STR1## wherein R is a heterocyclyl group; and R.sub.1 and R.sub.2 when taken together with the nitrogen to which they are attached are morpholino, thiomorpholino or a 6-8 membered nitrogen containing heterocyclic ring; methods for their preparation and use as agents for dissolving gallstones.
    Type: Grant
    Filed: September 14, 1979
    Date of Patent: February 24, 1981
    Assignee: Pfizer Inc.
    Inventor: Gerald F. Holland
  • Patent number: 4252739
    Abstract: This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yields. The process involves reacting an alkylating agent and an activated methylene compound in the presence of an onium compound, an alkali metal compound and water, which while only necessary in trace amounts can be present in substantial quantities.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: February 24, 1981
    Assignee: Emery Industries, Inc.
    Inventors: Richard G. Fayter, Jr., John F. White, Eugene G. Harris
  • Patent number: 4242348
    Abstract: Novel substituted-alkylidene-aminooxyalkylcarboxylic acid esters of the formula I and their acid addition salts have a strong antiinflammatory and a potent analgetic activity and a low toxicity. The substances may be used for treating rheumatic affections. They may be synthetized and formulated into preparations by known methods.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: December 30, 1980
    Assignee: Duphar International Research B.V.
    Inventors: Jan van Dijk, Johannes M. A. Zwagemakers
  • Patent number: 4238506
    Abstract: Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: December 9, 1980
    Assignee: Boehringer Mannheim GmbH
    Inventors: Kurt Stach, deceased, Elmar Bosies, Ruth Heerdt, Hans-Frieder Kuhnle, Felix H. Schmidt
  • Patent number: 4191761
    Abstract: The invention relates to copper complexes of 5,6,7,8-tetrahydroquinoline-8-thiocarboxamides. The copper complexes are of value in the treatment of ulcers and hypersecretion in mammals.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: March 4, 1980
    Assignee: John Wyeth & Brother Ltd.
    Inventor: Roger Crossley
  • Patent number: 4147694
    Abstract: 8-(1H-Tetrazol-5-ylcarbamoyl)quinolines and pharmaceutically acceptable salts thereof are potent anti-allergic agents.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: April 3, 1979
    Assignee: Riker Laboratories, Inc.
    Inventor: Edward H. Erickson