Abstract: Heterocyclylcarbonyl derivatives of urea having the formula ##STR1## wherein R is a heterocyclyl group; and R.sub.1 and R.sub.2 when taken together with the nitrogen to which they are attached are morpholino, thiomorpholino or a 6-8 membered nitrogen containing heterocyclic ring; methods for their preparation and use as agents for dissolving gallstones.
Abstract: This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yields. The process involves reacting an alkylating agent and an activated methylene compound in the presence of an onium compound, an alkali metal compound and water, which while only necessary in trace amounts can be present in substantial quantities.
Type:
Grant
Filed:
August 20, 1979
Date of Patent:
February 24, 1981
Assignee:
Emery Industries, Inc.
Inventors:
Richard G. Fayter, Jr., John F. White, Eugene G. Harris
Abstract: Novel substituted-alkylidene-aminooxyalkylcarboxylic acid esters of the formula I and their acid addition salts have a strong antiinflammatory and a potent analgetic activity and a low toxicity. The substances may be used for treating rheumatic affections. They may be synthetized and formulated into preparations by known methods.
Type:
Grant
Filed:
December 26, 1978
Date of Patent:
December 30, 1980
Assignee:
Duphar International Research B.V.
Inventors:
Jan van Dijk, Johannes M. A. Zwagemakers
Abstract: Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.
Type:
Grant
Filed:
June 29, 1978
Date of Patent:
December 9, 1980
Assignee:
Boehringer Mannheim GmbH
Inventors:
Kurt Stach, deceased, Elmar Bosies, Ruth Heerdt, Hans-Frieder Kuhnle, Felix H. Schmidt
Abstract: The invention relates to copper complexes of 5,6,7,8-tetrahydroquinoline-8-thiocarboxamides. The copper complexes are of value in the treatment of ulcers and hypersecretion in mammals.