The Chalcogen Is In An -oh, -sh, -om Or -sm Group (m Is Group Ia Or Group Iia Light Metal) Patents (Class 546/179)
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Patent number: 10988828Abstract: A method is provided for extracting scandium values from an ore feedstock. The method includes providing a feedstock of a copper ore which contains scandium values; extracting scandium values from the ore with a leaching solution, thereby obtaining a pregnant leachate; contacting the pregnant leachate with an ion exchange resin, thereby extracting scandium values from the pregnant leachate and forming a loaded extractant; stripping the scandium values from the loaded extractant with a stripping solution, thereby forming a loaded stripping solution; and precipitating the scandium values from the loaded stripping solution as a scandium-containing precipitate.Type: GrantFiled: November 21, 2018Date of Patent: April 27, 2021Assignee: Scandium Intrenational Mining CorporationInventor: Willem P. C. Duyvesteyn
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Patent number: 9493419Abstract: Quinoline derivatives showing anticancer activities against cancer cell lines of hepatocellular carcinoma (Hep3B), lung carcinoma (A549), esophageal squamous cell carcinoma (HKESC-1, HKESC-4 and KYSE150).Type: GrantFiled: December 22, 2011Date of Patent: November 15, 2016Assignee: The Hong Kong Polytechnic UniversityInventors: Johnny Cheuk-on Tang, Albert Sun Chi Chan, Kim Hung Lam, Sau Hing Chan
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Publication number: 20150141415Abstract: The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivatives thereof or a pharmaceutical salts thereof.Type: ApplicationFiled: November 7, 2014Publication date: May 21, 2015Inventors: Omonike Arike Olaleye, Sarah Finney John, Adaugo Chimzurum Isichei, Jun O Liu, Rosa Maldonado, Janice Endsley
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Publication number: 20150079304Abstract: A Schiff base compound configured to detoxify a toxic chemical agent. The toxic chemical agent includes at least one leaving group and the Schiff base compound includes an imine having at least one Lewis base and an alkyl substituent or an aryl substituent having an electron acceptor. The at least one Schiff base nitrogen is spaced way from the electron acceptor by a distance that ranges from about 200 pm to about 1000 pm.Type: ApplicationFiled: September 18, 2013Publication date: March 19, 2015Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventors: Jeffery Ray Owens, Wallace Bruce Salter, Katherine Moss Simpson
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Publication number: 20150057278Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein Cy1, Cy2, n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: ApplicationFiled: September 10, 2012Publication date: February 26, 2015Inventors: Dan Littman, Jun R. Huh, Ruili Huang, Wenwei Huang, Erika E. Englund
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Publication number: 20150038493Abstract: The present invention relates to a series of molecules derived from 2,3-diaminopropionic acid (DAP), comprising or not comprising an 8-hydroxyquinoline (8-HQ) motif, and to the use of said molecules for trapping an alpha-oxoaldehyde resulting particularly from the degradation of the glucose or for trapping an alpha-beta-unsaturated aldehyde, resulting particularly from the oxidative degradation of fatty acids. These molecules can have a further application in the fields of cosmetics, food processing, and pharmaceuticals.Type: ApplicationFiled: October 5, 2012Publication date: February 5, 2015Inventors: Guy Potier, André Nobumichi Sasaki, Nicolas Audic
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Publication number: 20150005500Abstract: Disclosed are novel ruthenium compounds of formula (Ia) and (Ib): wherein R1 and the moiety are defined herein. Also disclosed is a process for using these novel ruthenium compounds as catalysts for asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and excellent selectivities.Type: ApplicationFiled: June 24, 2014Publication date: January 1, 2015Applicant: Boehringer Ingelheim International GmbHInventors: Nizar HADDAD, Heewon LEE, Bo QU, Sonia RODRIGUEZ, Chris Hugh SENANAYAKE
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Publication number: 20140296251Abstract: Novel quinoline derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases.Type: ApplicationFiled: April 2, 2013Publication date: October 2, 2014Applicant: Annji Pharmaceutical Co., Ltd.Inventors: Ji-Wang Chern, Chen-Wei Huang, Pei-Teh Chang, Rahul Subhash Talekar
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Publication number: 20140235548Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a JAMM domain, including the JAMM domain of the CSN5 subunit of the COP9-signalsome (CSN), the JAMM domain of the Rpn11/Poh1/Psmd14 subunit of the 26S proteasome, the JAMM domain of AMSH, the JAMM domain of AMSH-LP, the JAMM domain of BRCC36, among other JAMM domains.Type: ApplicationFiled: May 10, 2012Publication date: August 21, 2014Applicant: Cleave Biosciences, Inc.Inventors: Han-Jie Zhou, Francesco Parlati, Matthieu Roufflet, Ethan D. Emberley, Raymond J. Deshaies, Seth Cohen
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Publication number: 20140204457Abstract: The present invention relates to quinolinium-derived single crystals for use in nonlinear optics, which exhibit high molecular orientation and macroscopic optical nonlinearity. When the quinolinium-derived crystals according to the present invention are applied to THz wave light sources, higher THz wave generating efficiency may be obtained as compared with inorganic crystals or existing organic M crystals.Type: ApplicationFiled: February 28, 2014Publication date: July 24, 2014Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventor: O-Pil KWON
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Publication number: 20140206876Abstract: Provided is a 2-(substituted ethynyl)quinoline derivative having an mGluR5 antagonistic activity and pharmaceutically acceptable salts thereof. The compound of the present invention can be useful as a medicament for treating and preventing mGluR5 receptor-mediated diseases such as Alzheimer's disease, senile dementia, Parkinson's disease, L-DOPA-induced dyskinesia, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, anxiety disorder, depression, neuropathic pain, drug dependence, fragile X syndrome, autism, migraine and gastroesophageal reflux disease (GERD).Type: ApplicationFiled: July 16, 2013Publication date: July 24, 2014Inventors: Sun Joon MIN, Yong Seo CHO, Ae Nim PAE, Eun Jeong LIM, Ji Yeong KIM, Myung Hee SON, Jae Kyun LEE
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Patent number: 8653260Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of ?3-adrenoceptor.Type: GrantFiled: June 20, 2012Date of Patent: February 18, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Richard Berger, Lehua Chang, Scott D. Edmondson, Stephen D. Goble, Sookhee Nicole Ha, Nam Fung Kar, Ihor E. Kopka, Bing Li, Gregori J. Morriello, Chris R. Moyes, Ding-Ming Shen, Liping Wang, Cheng Zhu
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Publication number: 20140031388Abstract: Anticancer compounds according to formula I are described herein. wherein R1, R2, R3 and R4 are selected from H, CH3, OH, SH, OCH3, NHR?, halogen, CF3, N-linked pyrrolidine, and SO2NHR?, or any combination thereof; R5 is an alkyl, alkenyl, or alkaryl group including from 4 to 11 carbons, X is selected from CH2, CHOH, C?O, S?O, O?S?O, and an oxetane ring, Y is selected from CH2, O, and NH, and R? is a H, aryl, or a lower alkyl group, or pharmaceutically acceptable salts thereof. The compounds have been shown to facilitate site-specific dephosphorylation of Akt at Ser-473, thereby inactivating Akt and decreasing dysregulation of Akt signaling that can occur in cancer cells.Type: ApplicationFiled: July 26, 2013Publication date: January 30, 2014Inventors: Ching-Shih Chen, Dasheng Wang, Samuel K. Kulp
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Patent number: 8633320Abstract: Disclosed are methods for the preparation of bromo-substituted quinolines of the formula (I) where R is aryl, heteroaryl, alkyl, alkenyl or alkynyl, which are useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections: Formula (I).Type: GrantFiled: May 3, 2010Date of Patent: January 21, 2014Assignee: Boehringer Ingelheim International GmbHInventors: Nitinchandra D. Patel, Chris H. Senanayake, Wenjun Tang, Xudong Wei, Nathan K. Yee
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Publication number: 20130015431Abstract: Invention relates to a single step preparation of alkali metal quinolate of general formula 1 wherein M=Lithium, sodium or potassium; R?H, alkyl (C1-C6), alkoxy, aryl, aryloxy, amino, amido or halogen (Cl, F, Br, I) which is substituted or unsubstituted with direct reaction of metal with 8-hydroxyquinoline. Substituted 8-hydroxyquinoline optionally have at least one substituent selected from the group consisting of alkyl, alkoxy, aryl, aryloxy, amino, amido at 2, 5 or 7 position. Halogen substituted 8-hydroxyquinolates are also prepared from this method in the yield of 90-95% from polar solvents like acetonitrile. These complexes are useful as light emitting and electron injecting materials in organic electronic devices. Also the doping of these materials in electron transport materials improves their electron mobility.Type: ApplicationFiled: June 21, 2012Publication date: January 17, 2013Inventors: Modeeparampil Narayanan Kamalasanan, Ritu Srivastava, Amit Kumar, Ishwar Singh, Sandeep Kumar Dhawan, Sukhwant Singh Bawa
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Publication number: 20120225903Abstract: The invention relates to 2-substituted quinoline derivatives, to a method for preparing same, and to the use thereof for drug production, particularly for treating infections caused by protozoa, such as leishmaniases, trypanosomiases, toxoplasmoses, and/or infections caused by retroviruses such as, for example, HIV or HTLV.Type: ApplicationFiled: May 15, 2009Publication date: September 6, 2012Inventors: Alain Fournet, Bernardin Akagah, Bruno Figadere, Anh Tuan Lormier
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Publication number: 20120165534Abstract: Disclosed are methods for the preparation of bromo-substituted quinolines of the formula (I) where R is aryl, heteroaryl, alkyl, alkenyl or alkynyl, which are useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections: Formula (I).Type: ApplicationFiled: May 3, 2010Publication date: June 28, 2012Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Nitinchandra D. Patel, Chris H. Senanayake, Wenjun Tang, Xudong Wei, Nathan K. Yee
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Publication number: 20120130074Abstract: This invention, which involves “the preparation method of 8-hydroxyquinoline metallic compound”, is a synthetic method of organic electroluminescent materials. The preparation method of compound Mqnqm? is to add solution prepared by Zengshui solvent and industrial ligand into reaction vessel, stir it at a certain temperature, and then achieve high-purity product, as for the Mqnqm?, M stands for Al, Li, n stands for 1-3, m is 0-2, q is 8-hydroxyquinoline and its derivatives, and q? is ligand different from q. Zengshui solvent is adopted in this invention which can react effectively and thus reducing reaction time and avoiding cumbersome operation and the refining process; this invention also increases total yield and purity, the mother liquor obtained can be recycled, which reduces environment pollution and cost as well.Type: ApplicationFiled: March 30, 2010Publication date: May 24, 2012Inventors: Lei Dai, Lifei Cai, Hongyu Zhao
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Publication number: 20110301163Abstract: Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1 and/or angiogenesis, wherein a compound of the invention is administered to a subject.Type: ApplicationFiled: October 6, 2009Publication date: December 8, 2011Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Jun O. Liu, Joong Sup Shim, Curtis R. Chong, Shridhar Bhat
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Publication number: 20110251238Abstract: Method for treating or preventing a PPAR-responsive condition in a subject, comprising administering to the subject a PPAR agonist that comprises a 8-hydroxyquinoline-methylene-N- group in an amount effective to activate a PPAR polypeptide.Type: ApplicationFiled: December 23, 2009Publication date: October 13, 2011Applicant: BIOPHARMEDInventors: Jean-Louis Kraus, Olivier Blin, Frédéric Champavere
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Patent number: 7964729Abstract: Peptidyl sensors comprise a metal-binding peptide and one or two kinase recognition sequences with a hydroxyamino acid that can be phosphorylated in the presence of a kinase.Type: GrantFiled: August 28, 2006Date of Patent: June 21, 2011Assignee: Massachusetts Institute of TechnologyInventors: Barbara Imperiali, Elvedin Lukovic, Dora Carrico-Moniz
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Publication number: 20100279340Abstract: Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.Type: ApplicationFiled: February 11, 2008Publication date: November 4, 2010Applicant: NYUInventors: Thomas Wisniewski, Jaeki Min, Qian Li, Young-Tae CHANG
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Patent number: 7767672Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.Type: GrantFiled: November 3, 2006Date of Patent: August 3, 2010Assignee: Vertex Pharmaceuticals IncorporatedInventors: Hayley Binch, Michael Mortimore, Chris Davis, Dean Boyall, Simon Everitt, Daniel Robinson, Sharn Ramaya, Damien Fraysse, John Studley, Andrew Miller, Michael O'Donnell, Alistair Rutherford, Joanne Pinder
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Publication number: 20100099674Abstract: A means for decreasing bacterial virulence in a mammal including man or in a plant by inhibition of the Type III secretion system at concentrations that do not prevent or substantially reduce bacterial growth comprises an N-substituted 7-quinolylmethyl amine, in particular one that is further substituted in 5- and 8-position on the quinoline ring. A corresponding therapeutic method and a pharmaceutical composition are also disclosed.Type: ApplicationFiled: March 18, 2008Publication date: April 22, 2010Applicant: Innate Pharmaceuticals ABInventor: Mikael Elofsson
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Publication number: 20090227626Abstract: The invention relates to compounds of general formula (I), to the process for the preparation thereof and to the use thereof as a therapeutic agent.Type: ApplicationFiled: August 4, 2006Publication date: September 10, 2009Applicant: PALUMED S.A.Inventors: Céline Deraeve, Marguerite Pitie, Christophe Boldron, Bernard Meunier
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Patent number: 7585976Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.Type: GrantFiled: January 26, 2006Date of Patent: September 8, 2009Assignee: Eisai Co., Ltd.Inventors: Silvio A. Campagna, Francis G. Fang, James J. Kowalczyk, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
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Publication number: 20080194609Abstract: The present application relates to novel tetrahydroquinoline derivatives, to a process for their preparation, to their use on their own or in combination for treating and/or preventing diseases and to their use for preparing medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinemias, dyslipidemias, hypertriglyceridemias, hyperlipidemias, hypercholesterolemias and arteriosclerosis.Type: ApplicationFiled: December 10, 2005Publication date: August 14, 2008Applicant: Bayer HeathCare AGInventors: Hilmar Bischoff, Heike Gielen-Haertwig, Volkhart Li, Carsten Schmeck, Michael Thutewohl, Martina Wuttke, Alexandros Vakalopoulos, Olaf Weber
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Publication number: 20080177075Abstract: The present invention relates to the use of a zinc ion chelating agent for the manufacture of a composition for intra-vaginal administration for the control of egg fertilisation by sperm, for progeny gender determination and/or for reducing the incidence of defective progeny.Type: ApplicationFiled: May 3, 2005Publication date: July 24, 2008Applicant: AQ+PLC Stephen Mabbott AssociatesInventor: Russell Taylor
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Publication number: 20080063599Abstract: The invention relates to compounds having general formulae I, II and III, which can be used to diagnose and monitor diseases associated with the deposit of amyloid proteins in the central nervous system. The invention also relates to the use of the inventive compounds in the diagnosis of the aforementioned diseases, to pharmaceutical compositions containing the compounds and to methods of preparing said compounds.Type: ApplicationFiled: January 14, 2002Publication date: March 13, 2008Inventors: Jorge Setoain Quinquer, Carlos Piera Pena, Isabel Ramirez De Arellan Serna
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Publication number: 20070208079Abstract: The present invention relates to the use of certain novel myriceric acid derivatives of the formula: which are inhibitors of nuclear factor kappa B (NF-?B) and inhibit the activity of the endothelin receptor for use in the treatment of cardiovascular and inflammatory diseases and for cancers susceptible to an NF-?B inhibitor and an endothelin receptor inhibitor. The present invention also relates to compounds and methods useful to inhibit cell proliferation and for the induction of apoptosis.Type: ApplicationFiled: March 1, 2007Publication date: September 6, 2007Applicant: SaviPu PharmaceuticalsInventors: Inderjit Kumar Dev, Ven Subbiah
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Patent number: 7265115Abstract: Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.Type: GrantFiled: April 11, 2003Date of Patent: September 4, 2007Assignee: Abbott LaboratoriesInventors: William H. Bunnelle, Daniela Barlocco Cristina, Jerome F. Daanen, Michael J. Dart, Michael D. Meyer, Keith B. Ryther, Michael R. Schrimpf, Kevin B. Sippy, Richard B. Toupence
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Patent number: 7084276Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, R4, R5, and R6 are as defined in the specification, or a N-oxide thereof or a pharmaceutically acceptable salt thereof or a prodrug thereof.Type: GrantFiled: May 13, 2004Date of Patent: August 1, 2006Assignee: WyethInventors: An Thien Vu, Stephen Todd Cohn, Richard Eric Mewshaw
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Patent number: 7071177Abstract: This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.Type: GrantFiled: April 26, 2001Date of Patent: July 4, 2006Assignee: Syntex (U.S.A.) LLCInventors: Nancy Elisabeth Krauss, Taraneh Mirzadegan, David Bernard Smith, Keith Adrian Walker
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Patent number: 6933301Abstract: A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in a therapeutically effective amount. The cold receptor agonist may be represented by the general formula 1-[R1-phenyl]-4-[R2-phenyl]-1,2,3,6-tetrahydropyrimidine-2-one wherein: R1 is -hydroxy, -chloro, -fluoro, -alkyl, -acetoxy, -trifluoromethyl; and R2 is -nitro, -chloro, -fluoro, -alkyl, -trifluoromethyl. Therapeutic compositions of the invention when formulated for delivery to the mucous membranes of the nose and throat alleviate the sensations of airway obstruction and provide symptomatic relief of upper airway breathing disorders.Type: GrantFiled: October 8, 2002Date of Patent: August 23, 2005Inventor: Edward T. Wei
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Patent number: 6897317Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.Type: GrantFiled: March 31, 2003Date of Patent: May 24, 2005Assignee: Bayer AktiengesellschaftInventors: Gunter Schmidt, Jürgen Stoltefuss, Michael Lögers, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
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Patent number: 6855711Abstract: Use of a compound of formula (I), wherein R1 is H or hydrocarbyl; R2 is a hydrophobic radical; R3 is 3-(C2-C6)acyl-4-hydroxyphenyl, 3-hydroxyimino (C2-C6)-alkyl-4-hydroxyphenyl, or COOZ, wherein Z is H, (C1-C6) alkyl, aryl, aryl or ar(C1-C6) alkyl; and n is 1-20; and of a compound of formula (II), wherein R4 is (C1-C6) alkyl, cyano (C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) alkyl or —CH2NR7R8, wherein R7 and R8, the same or different, is each H or (C1-C6) alkyl, or together with the N atom form a saturated or unsaturated 5-7 membered ring optionally containing a further heteroatom selected from N, O or S, the further N atom being optionally substituted, and either R5 is H and R6 is (C2-C6) acyl or hydroxyimino (C2-C6) alkyl, or R5 and R6 together with the phenyl ring form a quinoline, a 1,2,3,4-tetrahydroquinoline or a perhydroquinoline ring, for the preparation of pharmaceutical compositions for the treatment of Parkinson's disease or stroke.Type: GrantFiled: June 7, 2000Date of Patent: February 15, 2005Assignees: Yeda Research and Development Co. Ltd., Technion Research and Development Foundation Ltd.Inventors: Rivka Warshawsky, Moussa B. H. Youdim, Dorit Ben-Shachar, Abraham Warshawsky
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Patent number: 6855824Abstract: The present invention provides a production method of quinoline derivative (V) wherein each symbol is as defined in the Specification, which includes reacting quinolinecarbaldehyde (I) with any of the compounds (II) to (IV) in the presence of a base, followed by hydrolysis.Type: GrantFiled: February 19, 2001Date of Patent: February 15, 2005Assignees: Kuraray Co., Ltd., Nissan Chemical Industries, Ltd.Inventors: Kuniaki Tatsuta, Shigeki Kikuyama, Yoshin Tamai
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Patent number: 6818767Abstract: Quinoline derivatives are useful as neuropeptide Y (NPY) receptor ligands and are particularly effective as neuropeptide Y (NPY) antagonists. These compounds are useful in pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders, or obesity.Type: GrantFiled: May 20, 2002Date of Patent: November 16, 2004Assignee: Hoffmann-La Roche Inc.Inventors: Werner Mueller, Werner Neidhart, Philippe Pflieger, Jean-Marc Plancher
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Patent number: 6815547Abstract: Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described.Type: GrantFiled: March 14, 2003Date of Patent: November 9, 2004Assignee: Aventis Pharma S.A.Inventors: Eric Bacque, Serge Mignani, Jean-Luc Malleron, Michel Tabart, Michel Evers, Fabrice Viviani, Youssef El Ahmad, Stéphane Mutti, Christophe Daubié
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Patent number: 6806277Abstract: Quinolylpropylpiperidine derivatives of general formula (I) in which: R1 is NH2, alkylamino, dialkylamino, hydroxyamino, alkyl(alkyloxy)amino or alkyloxyamino, R2 is a carboxyl, carboxymethyl or hydroxymethyl radical, R3 is alkyl (1 to 6C) substituted by phenylthio which can itself carry 1 to 3 substituents selected from halogen, OH, alkyl, alkyloxy, CF3, OCF3, COOH, alkyloxycarbonyl, CN and NH2, by cycloalkylthio (3 to 7 members) or by heteroarylthio (5 to 6 members) comprising 1 to 4 heteroatoms selected from N, S and O and optionally itself substituted [by halogen, OH, alkyl, alkyloxy, CF3, OCF3, ═O, COOH, alkyloxycarbonyl, CN or NH2] or R3 is propargyl substituted by phenyl which can itself carry 1 to 3 substituents selected from halogen, OH, alkyl, alkyloxy, CF3, OCF3, COOH, alkyloxycarbonyl, CN and NH2 or substituted by cycloalkyl comprising 3 to 7 members or substituted by 5- to 6-membered heteroaryl comprising 1 to 4 heteroatoms chosen from N, O or S and optionally itself substitutedType: GrantFiled: July 18, 2003Date of Patent: October 19, 2004Assignee: Aventis, Pharma S.A.Inventors: Eric Bacqué, Jean-Luc Malleron, Serge Mignani, Michel Tabart
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Patent number: 6696434Abstract: This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.Type: GrantFiled: December 12, 2002Date of Patent: February 24, 2004Assignee: Aventis Pharmaceuticals Inc.Inventors: Michael R. Myers, Wei He, Alfred P. Spada, Martin P. Maguire
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Patent number: 6620947Abstract: Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.Type: GrantFiled: August 26, 2002Date of Patent: September 16, 2003Assignee: Alcon, Inc.Inventors: Pete Delgado, Raymond E. Conrow, William D. Dean, Michael S. Gaines
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Patent number: 6602884Abstract: Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described.Type: GrantFiled: March 13, 2002Date of Patent: August 5, 2003Assignee: Aventis Pharma S.A.Inventors: Eric Bacqué, Serge Mignani, Jean-Luc Malleron, Michel Tabart, Michel Evers, Fabrice Viviani, Youssef El Ahmad, Stéphane Mutti, Christophe Daubié
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Patent number: 6562750Abstract: A catalyst composition for the polymerization of olefins is provided, comprising a bis(hydroxy aromatic nitrogen ligand) transition metal catalyst precursor and an activating cocatalyst.Type: GrantFiled: January 9, 2002Date of Patent: May 13, 2003Assignee: Univation TechnologiesInventors: Walter Thomas Reichle, Frederick John Karol
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Patent number: 6482834Abstract: This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.Type: GrantFiled: April 6, 2001Date of Patent: November 19, 2002Assignee: Aventis Pharmaceuticals Inc.Inventors: Alfred P. Spada, Wei He, Michael R. Myers
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Patent number: 6387926Abstract: Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.Type: GrantFiled: May 29, 1998Date of Patent: May 14, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Rajeev S. Bhide, Charles Z. Ding, John T. Hunt, Soong-Hoon Kim, Katerina Leftheris
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Patent number: 6380390Abstract: A catalyst composition for the polymerization of olefins is provided, comprising a bis(hydroxy aromatic nitrogen ligand) transition metal catalyst precursor and an activating cocatalyst.Type: GrantFiled: January 13, 2000Date of Patent: April 30, 2002Assignee: Univation Technologies, LLCInventors: Walter Thomas Reichle, Frederick John Karol
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Patent number: 6362339Abstract: A method for making metal (8-quinolinolate) complexes from air and moisture stable reagents is described. For example, the making of aluminum tris(quinolinolates), such as tris(8-hydroxyquinolinato), from aluminum (III) carboxylates, such as aluminum lactate and aluminum stearate, is described. Examples of bis and tris metal (8-quinolinolates) as well as single and mixed ligand complexes are given.Type: GrantFiled: October 6, 1999Date of Patent: March 26, 2002Assignee: 3M Innovative Properties CompanyInventor: Fred Boyle McCormick
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Patent number: 6291477Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.Type: GrantFiled: March 10, 2000Date of Patent: September 18, 2001Assignee: Bayer AktiengesellschaftInventors: Gunter Schmidt, Jürgen Stoltefuss, Michael Lögers, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
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Patent number: 6166041Abstract: Novel compounds which are effective PDE IV inhibitors are disclosed. The present invention is directed to compounds having the general formula I ##STR1## wherein: X is a halogen;Q is --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --, a single or a double bond, or --NR.sub.1 --;R.sub.1 is a C.sub.Type: GrantFiled: November 3, 1997Date of Patent: December 26, 2000Assignee: Euro-Celtique, S.A.Inventors: David J. Cavalla, Mark Chasin, John W F Whitehead, Lesley Walton, Andrew C. Mansfield