Acyclic Nitrogen Bonded Directly To A -c(=x)- Group, Wherein X Is Chalcogen Patents (Class 546/224)
  • Patent number: 4138492
    Abstract: The invention relates to aromatic amides N-substituted by heterocyclic groups. More particularly, the invention relates to substituted benzoic acid amides of 1-arylalkylamino or aminoalkyl-N-heterocyclic rings and to pharmaceutical compositions thereof, which have the ability to antagonize the effects of dopamine or dopaminergic agents of endogenous or exogenous origin and which may be used for the treatment of nausea and vomiting resulting from gastrointestinal disorders, congestive heart failure, post operative conditions, etc., other gastrointestinal disorders such as dyspepsia, flatulence, bile regurgitations, hiatus hernia, peptic ulcer, reflux aerophagitis, gastritis, duodenitis, and cholethiasis, and a variety of conditions affecting the central nervous system such as acute and chronic psychoses, maniacal psychosis, schizophrenias, serious disturbances of behavior and non-melancholic depressive state and migraine.
    Type: Grant
    Filed: March 17, 1975
    Date of Patent: February 6, 1979
    Assignee: Anphar, S.A.
    Inventors: Armando V. Noverola, Jose P. Soto, R. G. W. Spickett
  • Patent number: 4126689
    Abstract: Novel N-aryl-N-(1-L-4-piperidinyl)arylacetamides useful as antiarrhythmic agents, a method of treating arrhythmia which comprises the systemic administration of such compounds to warm-blooded animals and pharmaceutical compositions to be used therefor.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: November 21, 1978
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Stefan Sanczuk, Hubert K. F. Hermans