Plural Pyridine Or Partially Hydrogenated Pyridine Rings Patents (Class 546/255)
  • Patent number: 10563120
    Abstract: Electrochromic compounds and optical articles containing them The present invention relates to a group of novel electrochromic compounds. More specifically, it relates to electrochromic compounds comprising one or several pyridinium rings and the use of these compounds as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: February 18, 2020
    Assignee: Essilor International
    Inventors: Samuel Archambeau, Claudine Biver, Fabien Berit-Debat, Stuart Aiken, Christopher David Gabbutt, Bernard Mark Heron, Thomas David Broadbent
  • Patent number: 10023583
    Abstract: The problem to be solved by the present invention is to provide a compound suitable for a pharmaceutical composition, specifically a pharmaceutically composition for treating nocturia. The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, would maintain and/or increase an endogenous AVP level to enhance the antidiuretic effect, which would contribute to a decreased number of nocturnal voids, and have extensively studied compounds which inhibit P-LAP. As a result, the inventors have found that (2R)-3-amino-2-(bi-cyclic pyridylmethyl)-2-hydroxy-propanoic acid derivatives have excellent P-LAP inhibitory activity. The inventors have evaluated antidiuretic effects in water-loaded rats and have found that the compounds increase endogenous AVP levels by inhibiting P-LAP and consequently reduce urine production.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: July 17, 2018
    Assignees: Astellas Pharma Inc., KOTOBUKI PHARMACEUTICAL CO., LTD.
    Inventors: Kenichi Kawaguchi, Akihiro Ishihata, Akira Kanai, Yusuke Inagaki, Masashi Hiramoto, Kentaro Enjo, Hajime Takamatsu
  • Patent number: 9718804
    Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: August 1, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Guanglin Luo, Ling Chen, Gene M. Dubowchik, Swanee E. Jacutin-Porte, Vivekananda M. Vrudhula, Senliang Pan, Prasanna Sivaprakasam, John E. Macor
  • Patent number: 9357783
    Abstract: A method for inhibiting hatching of an ectoparasite egg, the method comprising exposing the ectoparasite egg to at least one metal chelating agent and/or metalloprotease inhibitor, wherein the metal chelating agent is a compound comprising at least two heteroatoms able to simultaneously coordinate with a metal ion, at least one of the two heteroatoms being selected from nitrogen, sulfur, oxygen and phosphorus, wherein the compound comprises at least one carbocyclic ring substituted with at least one heteroatom and/or with a substituent containing at least one heteroatom, or the compound comprises at least one heterocyclic ring containing at least one heteroatom, wherein said heterocyclic ring is optionally substituted with at least one heteroatom and/or with a substituent containing at least one heteroatom is provided. Methods of treating ectoparasite infestations and compositions for use in such methods are also provided.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: June 7, 2016
    Assignee: HatchTech Pty Ltd.
    Inventor: Vernon Morrison Bowles
  • Patent number: 9212171
    Abstract: The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3?, R4, R4?, R5, R6, R6?, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: December 15, 2015
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Georg Jaeschke, Synese Jolidon, Lothar Lindemann, Heinz Stadler, Eric Vieira
  • Patent number: 9115066
    Abstract: Provided herein are trisubstituted methyl alcohols, preferably pH indicators that are substituted with optionally substituted aryl and or optionally substituted heteroaryl groups, and optionally include one or more polymerizable substituents.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 25, 2015
    Assignee: Indicator Systems International, Inc.
    Inventors: Gerald F. Swiss, Photon Rao, Ram W. Sabnis
  • Publication number: 20150137084
    Abstract: Triptycene derivatives having symmetric or asymmetric substituents are provided. The triptycene derivatives of the present invention may be applied in phosphorescent lighting devices ranging from deep blue to red and may be applied as a host material, an electron transporting material or a hole transporting material. An OLED device is also herein disclosed.
    Type: Application
    Filed: May 19, 2014
    Publication date: May 21, 2015
    Applicant: National Tsing Hua University
    Inventors: Chien-Hong CHENG, Ho-Hsiu CHOU, Cheng-Chang LAI
  • Patent number: 9005778
    Abstract: There is provided a novel organic compound suitably used for a blue light-emitting device and an organic light-emitting device including the novel organic compound. The organic compound is an acephenanthryleno[4,5-k]benzo[e]acephenanthrylene derivative.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: April 14, 2015
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tomonari Horikiri, Hiroyuki Tomono, Jun Kamatani
  • Publication number: 20150084016
    Abstract: An organic electroluminescent element including a luminescent compound represented by the following formula (in which R1 to R14 each independently represent a hydrogen atom, a deuterium atom, an alkyl group, an aryl group, a heteroaryl group, a fluorine atom, a cyano group, an amino group, an alkoxy group, an aryloxy group, a thio group, or a silyl group, and 8 to 13 groups out of R1 to R14 each represent a hydrogen atom or a deuterium atom.) in a light emitting layer has high durability and excellent chromaticity.
    Type: Application
    Filed: October 5, 2012
    Publication date: March 26, 2015
    Applicant: UDC IRELAND LIMITED
    Inventors: Toru Watanabe, Yuki Hirai, Tianhua Ouyang, Koji Takaku, Wataru Sotoyama, Tetsu Kitamura, Yasunori Yonekuta
  • Patent number: 8974919
    Abstract: The present invention relates to a novel anthracene derivative and an organic electronic device using the same. The anthracene derivative can act as a hole injecting, hole transporting, electron injecting and transporting, or light emitting material in an organic light emitting device and an organic electronic device. In particular, the anthracene derivative can act as a light emitting host. The organic electronic device according to the present invention has excellent characteristics in views of efficiency, the driving voltage, and the stability.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: March 10, 2015
    Assignee: LG Chem, Ltd.
    Inventors: Hye-Young Jang, Se-Hwan Son, Jae-Soon Bae, Jun-Gi Jang, Tae-Yoon Park
  • Patent number: 8968889
    Abstract: A novel organic compound suitable for emitting green light and an organic light-emitting device including the organic compound are provided. The organic compound is represented by general formula (1). In general formula (1), R1 to R18 are each independently selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: March 3, 2015
    Assignee: Canon Kabushiki Kaisha
    Inventors: Jun Kamatani, Kengo Kishino, Naoki Yamada, Akihito Saitoh
  • Patent number: 8962529
    Abstract: The present invention relates to novel, herbicidally active picolinic acid derivatives of the formula (I) and to processes for preparation thereof. The present invention further provides for the use thereof as a herbicide, especially as a herbicide for selective control of weed plants in useful plant crops, and as a plant growth regulator alone or in combination with safeners and/or in a mixture with other herbicides.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: February 24, 2015
    Assignee: Bayer Cropscience AG
    Inventors: Harmut Ahrens, Marco Brünjes, Hansjörg Dietrich, Elmar Gatzweiler, Isolde Häuser-Hahn, Stefan Lehr, Dirk Schmutzler
  • Patent number: 8957213
    Abstract: The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3?, R4, R4?, R5, R6, R6?, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: February 17, 2015
    Assignee: Hoffman-La Roche Inc.
    Inventors: Georg Jaeschke, Synese Jolidon, Lothar Lindemann, Heinz Stadler, Eric Vieira
  • Patent number: 8940774
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and/or gastrointestinal tract disorders.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: January 27, 2015
    Inventors: Peter Crooks, Linda Dwoskin, Roger Papke, Guangrong Zheng, Sangeetha Sumithran
  • Publication number: 20150014671
    Abstract: This organic electroluminescent element is manufactured by using an anthracene derivative having a pyridyl aryl group substituted with an alkyl represented by formula (1) as an electron transport material, and satisfies characteristics such as the following in an adequate and well-balanced manner: improves the external quantum efficiency of the light-emitting element, which is generally required by the electron transport material; reduces the drive voltage of the light-emitting element; and increases the life of the element. (In formula (1), Ar is a divalent or trivalent benzene or naphthalene; R is hydrogen or an alkyl with a carbon number of 1 to 6, but all of the Rs never simultaneously form hydrogen; and R1 to R4 are, individually, hydrogen, an alkyl with a carbon number of 1 to 6, a cycloalkyl with a carbon number of 3 to 6, or an aryl with a carbon number of 6 to 20.
    Type: Application
    Filed: January 15, 2013
    Publication date: January 15, 2015
    Applicant: JNC CORPORATION
    Inventors: Toshihiro Koike, Yohei Ono
  • Patent number: 8921564
    Abstract: The invention relates to basic bisazo compounds according to formula (I) wherein all substituents are defined as in Claim 1, their production, their use as dyestuffs as well as material dyed with these dyestuffs.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: December 30, 2014
    Assignee: Clariant Finance (BVI) Ltd.
    Inventors: Ludwig Hasemann, Friedrich Lehr, Martin Oberholzer, Heidrun Schene
  • Publication number: 20140374738
    Abstract: Provided is an acenaphtho[1,2-k]benzo[e]acephenanthrene derivative represented by general formula (1): wherein R1 to R16 are each independently selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group; and at least one of R1 to R8 and R10 to R15 is selected from a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 25, 2014
    Inventors: Jun Kamatani, Takayuki Horiuchi, Naoki Yamada, Akihito Saitoh
  • Publication number: 20140371266
    Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 18, 2014
    Inventors: Peter CROOKS, Linda P. DWOSKIN, Guangrong ZHENG, Sangeetha SUMITHRAN, Zhenfa ZHENG
  • Patent number: 8912208
    Abstract: The present invention provides (4-{4-[5-(Benzooxazol-2-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid which is useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: December 16, 2014
    Assignee: Novartis AG
    Inventors: Michael H. Serrano-Wu, Young-shin Kwak, Wenming Liu
  • Patent number: 8895585
    Abstract: An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: November 25, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Hideyasu Fujiwara, Kimihiko Sato, Shinsuke Mizumoto, Yuichiro Sato, Hideki Kurihara, Yohei Kubo, Hiyoku Nakata, Yasutaka Baba, Takashi Tamura, Hidenobu Kuniyoshi, Shinji Hagiwara, Mari Yamamoto
  • Patent number: 8890131
    Abstract: This invention relates to deuterated aryl-anthracene compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a deuterated compound.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: November 18, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Daniel David Lecloux, Adam Fennimore, Weiying Gao, Nora Sabina Radu, Weishi Wu, Vsevolod Rostovtsev, Michael Henry Howard, Jr., Hong Meng, Yulong Shen, Jeffrey A Merlo, Eric Maurice Smith
  • Publication number: 20140320578
    Abstract: To provide a condensed polycyclic compound shown in the following General Formula [1], in which X1 to X16 each are independently selected from a hydrogen atom, an aryl group, a heterocyclic group, an alkyl group, an alkoxy group, and an amino group and the aryl group, the heterocyclic group, the alkyl group, the alkoxy group, and the amino group may have a substituent.
    Type: Application
    Filed: April 25, 2014
    Publication date: October 30, 2014
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Naoki Yamada, Jun Kamatani, Kengo Kishino
  • Patent number: 8865905
    Abstract: A compound of formula IV: wherein R1, R2, and R3 are, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; Ar is heteroaryl, aryl, alkyl or cycloalkyl; b and c are, independently at each occurrence, an integer ranging from 0-4; a is an integer ranging from 0-3; and n is an integer ranging from 2 to 4.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 21, 2014
    Assignee: General Electric Company
    Inventors: Yangang Liang, Shengxia Liu, Rui Wang, Jie Liu, Kelly Scott Chichak
  • Publication number: 20140306190
    Abstract: Disclosed are a novel organic compound and an organic light emitting diode device using the same. More particularly, a novel organic compound having electrical stability, high charge transport capability, and light emitting performance, high glass transition temperature and being capable of preventing crystallization, and an organic light emitting diode device including an organic layer including the same are disclosed.
    Type: Application
    Filed: August 2, 2013
    Publication date: October 16, 2014
    Applicant: Samsung Display Co., Ltd.
    Inventors: Eun-Young LEE, Seok-Hwan HWANG, Young-Kook KIM, Hye-Jin JUNG, Jun-Ha PARK, Jin-O LIM, Sang-Hyun HAN, Eun-Jae JEONG, Soo-Yon KIM, Jong-Hyuk LEE
  • Publication number: 20140303206
    Abstract: The invention provides certain 3-pyridyl carboxamide-containing compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
    Type: Application
    Filed: October 1, 2012
    Publication date: October 9, 2014
    Inventors: Michael D. Altman, Kaleen Konrad Childers, Anthony Donofrio, John Michael Ellis, Sandra Lee Knowles, Alan B. Northrup
  • Publication number: 20140299192
    Abstract: The present disclosure provides a novel compound capable of greatly improving the lifetime, efficiency, electrochemical stability and thermal stability of an organic electronic device, and an organic electronic device including an organic compound layer containing the compound.
    Type: Application
    Filed: May 13, 2013
    Publication date: October 9, 2014
    Inventors: Sangbin Lee, Dong Hoon Lee, Hoyong Lee, Kongkyeom Kim, Jungi Jang, Sung Kil Hong, Changhwan Shin, Hyungjin Lee
  • Publication number: 20140299851
    Abstract: An organic electroluminescence element that uses a compound expressed by the following general formula has low inter-molecular interaction and high orientation during vapor deposition, and by using compounds that are resistant to aggregation, luminous efficiency is high, and there is little change in chromaticity accompanying drive deterioration (either V1 or W1 and either V2 or W2 form rings, the rings formed by V1 and V2 are six-membered rings, and the rings formed by W1 and W2 are five-membered rings; A2 to A4 and A6 to A8 represent CRZ or N, and RZ represents a hydrogen atom or a substituent; and R2, R3, R7, and R8 represent a hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, a fluorine atom, a hydrogen atom [sic], or a deuterium atom.).
    Type: Application
    Filed: April 11, 2012
    Publication date: October 9, 2014
    Applicant: UDC Ireland Limited
    Inventors: Koji Takaku, Tetsu Kitamura, Toru Watanabe, Yasunori Yonekuta
  • Patent number: 8841457
    Abstract: The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: September 23, 2014
    Assignee: Virdev Intermediates Pvt. Ltd.
    Inventors: Dharmesh Mahendra Shah, Sanjay Amratlal Solanki, Viral Narendra Jariwala, Ashok Vasantray Vyas, Ashokkumar Bhikhubhai Mistry
  • Publication number: 20140264312
    Abstract: The present invention relates to a novel stable benzo[h]hexaphene compound and an organic light-emitting device including the compound. The present invention provides a benzo[h]hexaphene shown in Claim 1.
    Type: Application
    Filed: October 2, 2012
    Publication date: September 18, 2014
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Hirokazu Miyashita, Jun Kamatani, Tetsuya Kosuge, Akihito Saitoh
  • Patent number: 8829194
    Abstract: The present invention relates to novel crystalline forms of (4-{4-[5-(6-Trifluoromethyl-pyridin-3-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid, sodium and their use in the treatment or prevention of a condition or a disorder associated with DGAT1 activity in animals, particularly humans. It also relates to processes for making such novel crystalline forms.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: September 9, 2014
    Assignee: Novartis AG
    Inventors: Paul Allen Sutton, Michael J. Girgis, Jessica Liang, Mahavir Prashad, Edwin Bernard Villhauer
  • Patent number: 8822683
    Abstract: Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: September 2, 2014
    Assignee: G1 Therapeutics, Inc.
    Inventors: Francis X. Tavares, Jay C. Strum
  • Patent number: 8809371
    Abstract: An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: August 19, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Hideyasu Fujiwara, Kimihiko Sato, Shinsuke Mizumoto, Yuichiro Sato, Hideki Kurihara, Yohei Kubo, Hiyoku Nakata, Yasutaka Baba, Takashi Tamura, Hidenobu Kuniyoshi, Shinji Hagiwara, Mari Yamamoto
  • Publication number: 20140225968
    Abstract: The present invention provides a novel organic compound having a high quantum yield and a high color purity. Provided is an organic compound represented by Formula (1) described in Claim 1. In Formula (1), R1 to R20 are each independently selected from hydrogen atoms, halogen atoms, substituted or unsubstituted alkyl groups, substituted or unsubstituted alkoxy groups, substituted or unsubstituted amino groups, substituted or unsubstituted aryl groups, substituted or unsubstituted heterocyclic groups, substituted or unsubstituted aryloxy groups, substituted or unsubstituted thiol groups, silyl groups, and cyano groups.
    Type: Application
    Filed: September 5, 2012
    Publication date: August 14, 2014
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Jun Kamatani, Naoki Yamada, Akihito Saitoh
  • Patent number: 8796461
    Abstract: A 1,2,4,5-substituted phenyl compound represented by the formula (1): wherein one of X1-X5 is nitrogen and the remainders of X1-X5 are carbon; R1 and R2 represent hydrogen, C1-6 alkyl or C1-6 alkoxy; R3 and R4 represent C1-6 alkyl or C1-6 alkoxy; and m is an integer of 0-4, and n is an integer of 0-5. This compound is useful as a constituent for an organic electroluminescent device.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: August 5, 2014
    Assignee: Tosoh Corporation
    Inventors: Tsuyoshi Tanaka, Mayumi Abe, Nobumichi Arai, Naoki Uchida, Takashi Iida
  • Publication number: 20140203252
    Abstract: An organic electroluminescent element which has a substrate, a pair of electrodes disposed on this substrate and composed of an anode and a cathode, and at least one organic layer disposed between these electrodes and including a light-emitting layer, and in which a compound expressed by General Formula 1-1 is contained in at least one layer of the aforementioned light-emitting layer(s) exhibits high luminous efficiency, excellent blue color purity, and little change in chromaticity accompanying drive deterioration.
    Type: Application
    Filed: June 5, 2012
    Publication date: July 24, 2014
    Applicant: UDC Ireland Limited
    Inventors: Tetsu Kitamura, Koji Takaku, Wataru Sotoyama, Yasunori Yonekuta, Toshihiro Ise, Saki Takada, Toru Watanabe
  • Patent number: 8779133
    Abstract: Provided are novel ligands for transition metal complexes which exhibit high coordination power with respect to metals by being free of substituents at the positions ortho to phosphorus or arsenic and which have electron-withdrawing power comparable to the highest level known in conventional ligands. One ligand includes a compound represented by General Formula (1): R1R2R3A or General Formula (2): R1R2A-Y-AR3R4 and having a total of 15 to 110 carbon atoms. In the formulae, A is phosphorus or arsenic; R1, R2, R3 and R4 are each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C2-20, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: July 15, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Toshinobu Korenaga, Takashi Sakai, Aram Ko
  • Publication number: 20140194605
    Abstract: A SERS tag comprising a core comprising at least two aggregated particles of a SERS enhancing material wherein the contact point between the particles defines a crevice; and a reporter molecule having a length sufficiently short to fit into the crevice and a conjugated path length which is as large as possible, provided the overall reporter molecule length is maintained sufficiently short to fit into the crevice.
    Type: Application
    Filed: March 13, 2014
    Publication date: July 10, 2014
    Applicant: Cabot Security Materials, Inc.
    Inventors: Felicia Tam, Marcelo E. Piotti, Richard G. Freeman
  • Patent number: 8772300
    Abstract: The present invention relates to ethynyl derivatives of formula I wherein Y is N or C—R3; R3 is hydrogen, methyl, halogen or nitrile; R1 is phenyl or pyridinyl, each of which is optionally substituted by halogen, lower alkyl or lower alkoxy; R2/R2? are each independently hydrogen, lower alkyl or lower alkyl substituted by halogen, or R2 and R2? together with the N-atom to which they are attached form a morpholine ring, a piperidine ring or an azetidine ring, each of which is unsubstituted or substituted one or more substituents selected from lower alkoxy, halogen, hydroxy and methyl; R4/R4? are each independently hydrogen or lower alkyl, or R4 and R4? together form a C3-5 cycloalkyl-, tetrahydrofuran- or an oxetane-ring; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: July 8, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Jaeschke, Synese Jolidon, Lothar Lindemann, Antonio Ricci, Daniel Rueher, Heinz Stadler, Eric Vieira
  • Patent number: 8772320
    Abstract: An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: July 8, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Hideyasu Fujiwara, Kimihiko Sato, Shinsuke Mizumoto, Yuichiro Sato, Hideki Kurihara, Yohei Kubo, Hiyoku Nakata, Yasutaka Baba, Takashi Tamura, Hidenobu Kuniyoshi, Shinji Hagiwara, Mari Yamamoto
  • Publication number: 20140183463
    Abstract: A condensed cyclic compound is represented by Formula 1, and an organic light-emitting device includes the condensed cyclic compound. The organic light-emitting device may include an organic layer containing the condensed-cyclic compound of Formula 1 and has low driving voltage, high emission efficiency, and long lifespan characteristics.
    Type: Application
    Filed: August 21, 2013
    Publication date: July 3, 2014
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Eun-Young Lee, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jun-Ha Park, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Jong-Hyuk Lee
  • Patent number: 8759818
    Abstract: This invention relates to deuterated aryl-anthracene compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a deuterated compound.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: June 24, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Daniel David LeCloux, Adam Fennimore, Weiying Gao, Nora Sabina Radu, Weishi Wu, Vsevolod Rostovtsev, Michael Henry Howard, Jr., Hong Meng, Yulong Shen, Jeffrey A. Merlo, Eric Maurice Smith
  • Publication number: 20140167007
    Abstract: A pyrene-based compound and an organic light-emitting diode including the pyrene-based compound are provided.
    Type: Application
    Filed: October 8, 2013
    Publication date: June 19, 2014
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Hye-Jin Jung, Seok-Hwan Hwang, Young-Kook Kim, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Jun-Ha Park, Eun-Young Lee, Chang-Ho Lee, Jong-Hyuk Lee
  • Publication number: 20140155407
    Abstract: The present invention relates to compounds which selectively inhibit CYP11B1. Preferably, the compounds of the present invention do not substantially inhibit CYP11B2. Moreover, the compounds of the present invention do not substantially inhibit CYP17 and/or CYP19, either. Amongst other applications of the compounds of the present invention, they can be used for the treatment of Cushing's syndrome or metabolic disease.
    Type: Application
    Filed: October 21, 2011
    Publication date: June 5, 2014
    Inventors: Rolf Hartmann, Ulrike Hille, Christina Zimmer, Carsten A. Vock, Qingzhong Hu
  • Publication number: 20140148487
    Abstract: The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 29, 2014
    Applicant: James Madison Innovations, Inc,
    Inventors: Kevin P. Minbiole, Kevin l Caren, Kyle n Seifert
  • Patent number: 8735591
    Abstract: An organic amine dimmer and a method for synthesizing the same are disclosed. The method comprises the following steps: (A) mixing an iron-containing compound (e.g., Fe2O3, FeCl3), a nitrate-containing compound, oxalate acid, 4,4?-trimethylenedipiperidine (TMDP), H3PO4, and 2 to 8 ml of water to form a mixture; (B) heating the mixture and maintaining the mixture at 160° C. or above for a first predetermined time; (C) cooling the mixture; and (D) placing the mixture at room temperature for a second predetermined time, to obtain an organic amine dimmer, wherein Fe(NO3)3 can serve as the iron-containing compound as well as the nitrate-containing compound.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: May 27, 2014
    Assignee: National Tsing Hua University
    Inventors: Sue-Lein Wang, Yu-Chuan Chang
  • Patent number: 8729107
    Abstract: Embodiments of the present disclosure provide a novel pyridine, pharmaceutical compositions comprising such pyridine, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In at least one embodiment of the method, the method comprises the step of administering to the mammal in need thereof with a pharmaceutical composition, or pharmaceutically acceptable salt, comprising 4-aminopyridine-3-methanol.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: May 20, 2014
    Assignee: Purdue Research Foundation
    Inventors: Richard B. Borgens, Riyi Shi, Stephen R. Byrn, Daniel T. Smith
  • Patent number: 8722208
    Abstract: Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of high driving stability, and of a simple structure. The organic EL device is constituted of an anode, organic layers containing a phosphorescent light-emitting layer, and a cathode piled one upon another on a substrate and a phosphine oxide derivative represented by general formula (1) is contained in a phosphorescent light-emitting layer, an electron-transporting layer, a hole-blocking layer, or an exciton-blocking layer. In general formula (1), L1 is a direct bond or an aromatic group with a valence of 1-3 and Ar1 is an aromatic group. The two Ar1 groups linked to the same nitrogen atom may form a nitrogen heterocycle and may further form a fused ring together with the said nitrogen heterocycle.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: May 13, 2014
    Assignee: Nippon Steel & Sumikin Chemical Co., Ltd.
    Inventors: Takahiro Kai, Hideki Tanaka, Mitsuru Suda, Toshihiro Yamamoto, Megumi Matsumoto
  • Patent number: 8716472
    Abstract: A tri-podal compound according to formula (I) wherein, each Z is the same and is a substituted or unsubstituted N-heteroaromatic single-, multiple-, or fused-ring; and each A is the same, and can represent a direct bond between the cyclohexane ring and Z, or a carboxamide group (—C(O)—N(H)—). Use of the compounds in combinatorial libraries, methods of making the tripodal compounds, sensor devices for detecting carbohydrate targets, and methods of using the tripodal compounds to detect carbohydrate targets in a sample are also disclosed.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: May 6, 2014
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Prakash B. Palde, Peter C. Gareiss
  • Patent number: 8703803
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and or gastrointestinal tract disorders.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: April 22, 2014
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Roger Papke, Guangrong Zheng, Sangeetha Sumithran
  • Patent number: 8691399
    Abstract: Compounds of formula I may be used in optoelectronic devices wherein R1 and R2 are, independently at each occurrence, H, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is an integer ranging from 0-2; b is 1 or 2; c is an integer ranging from 0-4; and Ar1 and Ar2 are independently heteroaryl.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: April 8, 2014
    Assignee: General Electric Company
    Inventors: Kelly Scott Chichak, Qing Ye