Metal Containing Catalyst Utilized Patents (Class 546/260)
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Patent number: 11014886Abstract: Disclosed is a method for preparing 2,2?-dipyridine and derivatives thereof. The method includes: using pyridine represented by formula I or a derivative thereof as a raw material to generate 2,2?-dipyridine represented by formula II by performing dehydrogenative coupling under the action of a supported catalyst in the presence of additives, where R is H, C1-C2 alkyl, Cl, or Br. The method of the present invention features wide adaptability to raw materials, high atomic utilization rate, high catalyst activity, long service life, and fewer by-products.Type: GrantFiled: April 4, 2018Date of Patent: May 25, 2021Assignee: NANJING REDSUN BIOCHEMISTRY CO., LTD.Inventors: Chaoran Luo, Wenkui Wang, Yi Xue, Xinchun Chen, Dianhai Zhou, Jianhua Jiang, Fujun Wang
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Patent number: 10265307Abstract: The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.Type: GrantFiled: November 16, 2017Date of Patent: April 23, 2019Assignees: Incyte Corporation, Incyte Holdings CorporationInventors: Chu-Biao Xue, Hao Feng, Yun-Long Li, Ke Zhang
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Patent number: 10017520Abstract: The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc inhibitors) and may be useful in treating in a subject in need thereof diseases associated with Myc and proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.Type: GrantFiled: December 10, 2015Date of Patent: July 10, 2018Assignee: Massachusetts Institute of TechnologyInventors: Angela N. Koehler, Eric Stefan, Francisco Caballero
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Patent number: 8742118Abstract: Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.Type: GrantFiled: October 18, 2012Date of Patent: June 3, 2014Assignee: F.I.S.—Fabbrica Italiana Sintetici S.p.A.Inventors: Francesco Fontana, Paolo Stabile
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Publication number: 20130109862Abstract: Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.Type: ApplicationFiled: October 18, 2012Publication date: May 2, 2013Applicant: F.I.S. FABRICA ITALIANA SINTETICI S.p.A.Inventor: F.I.S. FABRICA ITALIANA SINTETICI S.p.A.
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Patent number: 8293905Abstract: A bipyridine compound represented by the formula (1): wherein R1, R2 and R3 each independently represent a C1-C10 alkyl group which may be substituted etc., and R4, R5, R6, R7 and R8 each independently represent a hydrogen atom etc., a transition metal complex obtained by contacting a bipyridine compound represented by the formula (1) with a compound of a transition metal belonging to Group 9, 10 or 11, and a method for production of a conjugated aromatic compound comprising reacting an aromatic compound (A) wherein one or two leaving groups are bonded to an aromatic ring with an aromatic compound (A) having the same structure as that of the above-mentioned aromatic compound (A) or an aromatic compound (B) being structurally different from the above-mentioned aromatic compound (A) and having one or two leaving groups bonded to an aromatic ring, in the presence of the transition metal complex.Type: GrantFiled: June 18, 2008Date of Patent: October 23, 2012Assignee: Sumitomo Chemical Company, LimitedInventors: Taku Asaumi, Takashi Kamikawa
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Publication number: 20120245348Abstract: Disclosed herein are phosphine compounds represented by the general formula (4): and corresponding phosphonium salts represented by the general formula (4a): Also disclosed are processes for the preparation of these phosphines and phosphonium salts as well as their use as ligands in catalytic reactions.Type: ApplicationFiled: April 2, 2012Publication date: September 27, 2012Inventors: Herbert PLENIO, Christoph FLECKENSTEIN, Renat KADYROV, Juan ALMENA, Axel MONSEES, Thomas RIERMEIER
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Patent number: 8227614Abstract: The invention relates to the formation of synthesized fractal constructs and the methods of chemical self-assembly for the preparation of a non-dendritic, nano-scale, fractal constructs or molecules. More particularly, the invention relates to fractal constructs formed by molecular self-assembly, to create synthetic, nanometer-scale fractal shapes. In an embodiment, a nanoscale Sierpinski hexagonal gasket is formed. This non-dendritic, perfectly self-similar fractal macromolecule is comprised of bisterpyridine building blocks that are bound together by coordination to 36 Ru and 6 Fe ions to form a nearly planar array of increasingly larger hexagons around a hollow center.Type: GrantFiled: May 10, 2007Date of Patent: July 24, 2012Assignee: The University of AkronInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 7985830Abstract: Methods for synthesizing dimeric or polymeric reaction products of nitrogen aromatics comprise contacting a composition comprising the nitrogen aromatic with a catalyst composition. The catalyst comprises a first metal substrate having a second reduced metal coated on the substrate.Type: GrantFiled: December 30, 2009Date of Patent: July 26, 2011Assignee: GM Global Technology Operations LLCInventors: Andrew M. Mance, Tao Xie, Belabbes Merzougui, Charlene A. Hayden
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Patent number: 7906651Abstract: The present invention presents a catalyst that allows asymmetric hydroxymethylation reactions to progress with excellent asymmetric selectivity and a production method for optically active hydroxymethylated compounds using the catalyst. Optically active hydroxymethylated compounds are obtained with excellent asymmetric selectivity by using a catalyst obtained by mixing chiral ligands (for example, chemical formula 4) with scandium triflate and the like.Type: GrantFiled: January 27, 2005Date of Patent: March 15, 2011Assignee: Japan Science and Technology AgencyInventors: Shu Kobayashi, Kei Manabe
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Patent number: 7655749Abstract: Methods for synthesizing dimeric or higher polymeric reaction products of nitrogen aromatics comprise contacting a composition comprising the nitrogen aromatic with a catalyst composition. The catalyst is in particulate form and comprises a first metal substrate having a second reduced metal coated on the substrate.Type: GrantFiled: September 19, 2005Date of Patent: February 2, 2010Assignee: GM Global Technology Operations, Inc.Inventors: Andrew M. Mance, Tao Xie, Belabbes Merzougui, Charlene A. Hayden
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Publication number: 20070249683Abstract: The invention is concerned with dicarboxamide derivatives of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used in pharmaceutical compositions.Type: ApplicationFiled: April 11, 2007Publication date: October 25, 2007Inventors: Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
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Patent number: 6452014Abstract: Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are methods for assaying or screening for inhibitors of telomerase activity.Type: GrantFiled: December 22, 2000Date of Patent: September 17, 2002Assignee: Geron CorporationInventors: Tsutomu Akama, Ryan Holcomb, Richard L. Tolman
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Patent number: 6392047Abstract: Biaryls, e,g,. biphenyls, phenylpyridines, phenylfurans, phenylpyrroles, phenylthiophenes, bipyridines, pyridylfurans or pyridylpyrroles are prepared in high yields by coupling aromatics with an aromatic boric acid or boric ester in the presence of a palladaphosphacyclobutane catalyst.Type: GrantFiled: July 13, 2000Date of Patent: May 21, 2002Assignee: Clariant GmbHInventors: Holger Geissler, Steffen Haber, Andreas Meudt, Frank Vollmueller, Stefan Scherer
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Patent number: 6211242Abstract: This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by the general formula (I): wherein R1 is aryl optionally substituted with lower alkyl, etc., R2 is lower alkyl, etc., R3 is hydrogen, etc., R4 is aryl, etc., X is CH or N, and Y is CH or N, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.Type: GrantFiled: January 30, 1998Date of Patent: April 3, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Keiji Hemmi, Hirokazu Tanaka
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Patent number: 5824288Abstract: Novel precursors of ligands or use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.2-R.sub.10 are defined herein.Type: GrantFiled: August 21, 1997Date of Patent: October 20, 1998Assignee: Hoechst Celanese CorporationInventors: Wei-Jen Peng, Humberto Ramos, Jr., Daniel A. Aguilar
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Patent number: 5559214Type: GrantFiled: May 28, 1993Date of Patent: September 24, 1996Assignee: Sterling Winthrop Inc.Inventors: Daniel J. Delecki, Ashis K. Saha, Robert A. Snow
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Patent number: 5416217Abstract: Processes for the preparation of 2,2'-bipyridyls by reacting a pyridine base in the presence of an elemental nickel catalyst, along with an effective amount of borohydride salt and ammonium hydroxide to reduce the inactivation of the nickel catalyst during the reactions.Type: GrantFiled: June 22, 1993Date of Patent: May 16, 1995Assignee: Reilly Industries Inc.Inventors: Gerald R. Goe, Charles K. McGill, Angela R. sherman
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Patent number: 5221747Abstract: Processes for the preparation of 2,2'-bipyridyls by reacting a pyridine base in the presence of a nickel catalyst which comprises a significant amount of elemental nickel bound on a suitable support. In one embodiment the coupling reaction takes place in several reactor designs at a temperature of about 200.degree.-240.degree. C. and a pressure sufficient to maintain at least some of the base in a liquid state during the reaction. In other preferred embodiments, processes for preparing 2,2'-bipyridyls are conducted at a temperature between about 175.degree.-240.degree. C. These latter processes require that the nickel have a high specific Ni surface area.Type: GrantFiled: June 9, 1992Date of Patent: June 22, 1993Assignee: Reilly Industries, Inc.Inventors: Gerald R. Goe, Charles K. McGill, Angela R. Sherman
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Patent number: 5028712Abstract: The invention comprises cyclobutarene ketoanhydride monomers and the process for preparing them, and cyclobutarene ketocarboxy monomers. The monomers can be copolymerized with suitable difunctional monomers and subsequently processed to prepare highly crosslinked structures. The monomers can also be used to endcap oligomers with the cyclobutarene functionality. The endcapped oligomer can subsequently be processed to prepare a highly crosslinked network.Type: GrantFiled: May 24, 1990Date of Patent: July 2, 1991Assignee: The Dow Chemical CompanyInventor: Kenneth J. Bruza
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Patent number: 4996288Abstract: The invention comprises cyclobutarene ketoanhydride monomers and the process for preparing them, and cyclobutarene ketocarboxy monomers. The monomers can be copolymerized with suitable difunctional monomers and subsequently processed to prepared highly crosslinked structures. The monomers can also be used to endcap oligomers with the cyclobutarene functionality. The endcapped oligomer can subsequently be processed to prepare a highly crosslinked network.Type: GrantFiled: February 8, 1989Date of Patent: February 26, 1991Assignee: The Dow Chemical CompanyInventor: Kenneth J. Bruza
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Patent number: 4966972Abstract: A process for the preparation of 2,2'-bipyridyls by reacting a pyridine base in the presence of a nickel catalyst which comprises a significant amount of elemental nickel bound on a suitable support. The coupling reaction takes place in several reactor designs at a temperature of about 200.degree.-240.degree. C. and a pressure sufficient to maintain at least some of the base in a liquid state during the reaction.Type: GrantFiled: January 19, 1989Date of Patent: October 30, 1990Assignee: Reilly Industries, Inc.Inventors: Gerald L. Goe, Charles K. McGill, Angela R. Sherman
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Patent number: 4798894Abstract: Compounds containing at least one N,N-dialkylatable amino or amido group (e.g., aniline, dodecylamine, acetamide) are converted in a highly efficient manner into gem cyclodialkylated compounds by reaction with an unstrained cyclic ether (e.g., tetrahydrofuran) or a polyol (e.g., 1,4-butane diol) cyclizable to an unstrained ether using titanium dioxide catalysts that have prior to use:(1) a surface area of at least 70 square meters per gram (as determined by the BET method), and(2) the capability of chemically adsorbing at 100.degree. C. at least 35.times.10.sup.4 millimoles of gaseous ammonia per square meter of surface area.Type: GrantFiled: May 11, 1987Date of Patent: January 17, 1989Assignee: Ethyl CorporationInventor: Duane C. Hargis
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Patent number: 4560506Abstract: Compounds of the formula ##STR1## wherein A is a cycloalkyl ring, a substituted cycloalkyl ring, a phenyl ring, or a substituted phenyl ring and ##STR2## are various dipeptide groups are disclosed. The compounds possess angiotensin converting enzyme inhibition activity and depending upon the terminal amino acid may also possess enkephalinase inhibition activity.Type: GrantFiled: May 25, 1984Date of Patent: December 24, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: Harold N. Weller, III, Eric M. Gordon, Norma G. Delaney
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Patent number: 4474978Abstract: Process for the preparation of carbamates and/or derivatives thereof by reacting an organic compound containing at least one hydroxyl group with carbon monoxide and an organic nitrogeneous compound in the presence of a catalytic system based on palladium and a ligand according to the general formula: ##STR1## wherein L=N, P, As or Sb; R, R.sup.1, R.sup.2 and R.sup.3 are (un)substituted alkyl, aryl, alkaryl or aralkyl or R and R.sup.1 and/or R.sup.2 and R.sup.3 may form a ring together with the atom L to which they are attached; R.sup.4 and R.sup.5 are H or lower alkyl and n=2, 3 or 4, whereas carbon atoms between the groups L may be part of cyclic or non-cyclic unsaturated structures, and in the presence of an acid promoter.Type: GrantFiled: October 17, 1983Date of Patent: October 2, 1984Assignee: Shell Oil CompanyInventors: Eit Drent, Petrus W. N. M. Van Leeuwen
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Patent number: 4194046Abstract: 4,4'-Dipyridyls are produced by electrolysis of 4-unsubstituted pyridines in liquid ammonia containing a conducting salt, e.g., salts of tetraalkylammonium, alkali metal and alkaline earth metals, for example potassium chloride.Type: GrantFiled: March 15, 1979Date of Patent: March 18, 1980Assignee: Schering AktiengesellschaftInventor: Klaus Junghans
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Patent number: 4174447Abstract: A decarboxylation process for coupling aromatic compounds wherein cyclic hydrocarbons and heterocyclic compounds having at least one labile ring hydrogen are reacted with the mono silver salts of aromatic carboxylic acids, or mono silver salts of unsaturated compounds such as .alpha.,.beta.-ethylenically unsaturated acid compounds, or silver trifluoroacetate, or the mono silver salts are reacted with themselves, by heating to temperatures of 100.degree. to 500.degree. C. at pressures of 0.1 to 10 atmospheres, or by irradiating the reactants with ultraviolet light of 200 to 400 nanometers at temperatures of -30.degree. to 150.degree. C. The resulting dimers, trimers, polysubstituted polyphenyls, polyheterocyclics and trifluoromethylated aromatics are useful as heat transfer media, as intermediates for high molecular weight polymers, pesticides and petroleum additives, and as scintillation counters.Type: GrantFiled: February 26, 1975Date of Patent: November 13, 1979Assignee: Standard Oil Company (Indiana)Inventor: Ellis K. Fields