The Chalcogen Or The Acyclic Nitrogen Is Bonded Directly To The Six Membered Hetero Ring Patents (Class 546/292)
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Patent number: 4863936Abstract: Various substituted aminoalkylamino-2-pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.Type: GrantFiled: October 21, 1986Date of Patent: September 5, 1989Assignee: Smith Kline & French Laboratories LimitedInventor: George S. Sach
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Patent number: 4861799Abstract: A benzoylurea compound having the formula: ##STR1## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a methyl group, provided that X.sub.1 and X.sub.2 are not simultaneously hydrogen atoms, Y is independently a hydrogen atom, a halogen atom, an alkyl group which may be substituted by halogen, a --CO.sub.2 R.sub.1 group wherein R.sub.1 is a hydrogen atom, a cation or an alkyl group, or a --OR.sub.1 group wherein R.sub.1 is as defined above, A.sub.1 is .dbd.N--or ##STR2## wherein Y is as defined above, W is an oxygen atom, a sulfur atom or ##STR3## wherein R.sub.1 is as defined above, k is an integer of from 1 to 3, l is 0 or 1, and Ar is ##STR4## wherein Z is independently a hydrogen atom, a halogen atom, an alkyl group which may be substituted by halogen, an alkoxy group which may be substituted by halogen, a nitro group, a cyano group or a --S(O).sub.n R.sub.2 group wherein R.sub.2 is an alkyl group which may be substituted by halogen and n is 0, 1 or 2, A.sub.Type: GrantFiled: September 30, 1987Date of Patent: August 29, 1989Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Tadaaki Toki, Toru Koyanagi, Yasuhiro Fujii, Kiyomitsu Yoshida, Osamu Imai
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Patent number: 4853395Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.Type: GrantFiled: November 17, 1987Date of Patent: August 1, 1989Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
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Patent number: 4845107Abstract: Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula ##STR1## wherein R is selected from the group consisting of C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkoxy and halogen; and R.sub.1 is C.sub.1 -C.sub.6 haloalkyl; and fungicidally acceptable organic and inorganic salts thereof.Type: GrantFiled: October 29, 1987Date of Patent: July 4, 1989Assignee: ICI Americas Inc.Inventors: Don R. Baker, Keith H. Brownell
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Patent number: 4840953Abstract: 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula: ##STR1## wherein n is 0 or 1, R is --COR.sup.1, --CONR.sup.4 R.sup.5 or --CH.sub.2 R.sup.6, R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl, allythio, styryl, phenoxymethyl, thienylmethyl, C.sub.6 -C.sub.10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R.sup.2 and R.sup.3 each is hydrogen, C.sub.1 -C.sub.5 alkyl, carboxy, C.sub.2 -C.sub.5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R.sup.4 and R.sup.5 each is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl or phenyl optionally substituted, and R.sup.8 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.Type: GrantFiled: June 15, 1988Date of Patent: June 20, 1989Assignee: Shionogi & Co., Ltd.Inventors: Shigeru Matsutani, Yukio Mizushima, Masami Doteuchi, Yasunobu Ishihara
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Patent number: 4833143Abstract: Compounds of formula I ##STR1## in which R.sub.1 is a heterocyclic ring containing one or more heteroatoms selected from N, O and S;in which R.sub.2 is H, a straight or branched chain alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 3 to 6 carbon atoms, an alkynyl group containing 3 to 6 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms;in which R.sub.3, is H, a straight chain alkyl group containing 1 to 3 carbon atoms or a formyl groupin which R.sub.4, R.sub.5 and R.sub.6 which may be the same or different, are H, halo, trifluoromethyl, hydroxy, an alkyl group containing 1 to 3 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms, phenyl or R.sub.4 and R.sub.5, together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring;and their pharmaceutically acceptable salts have utility in the treatment of depression. Pharmaceutical compositions and processes for the preparation of compounds of formula I are disclosed.Type: GrantFiled: September 28, 1983Date of Patent: May 23, 1989Assignee: The Boots Company PLCInventors: Bernard J. Armitage, John R. Housley, James E. Jeffery, David N. Johnston
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Patent number: 4826531Abstract: Acrylic acid derivatives having the formula (I): ##STR1## and stereoisomers thereof, wherein W is R.sup.1 O.sub.2 C--C.dbd.CH--ZR.sup.2, R.sup.1 and R.sup.2 are alkyl or fluoroalkyl groups, and Z is oxygen or sulphur; A, B, D and E are hydrogen, halogen, hydroxy or optionally substituted alkyl, alkoxy, aralkyl, arylalkoxy, alkenyl, alkynyl, aryl, aryloxy, arylthio, heteroaryloxy, heteroarylthio, acyloxy, amino, arylazo or acylamino, nitro, cyano, --CO.sub.2 R.sup.3, --CONR.sup.3 R.sup.4, --COR.sup.3, --CR.sup.3 .dbd.NR.sup.4, --N.dbd.CR.sup.3 R.sup.4 or --S(O).sub.n R.sup.3 groups; any two of the groups A, B, D and E, when they are in adjacent positions on the ring, optionally join to form a fused ring, n is 0, 1 or 2; and R.sup.3 and R.sup.4 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl or optionally substituted aryl or aralkyl; and metal complexes thereof. These compounds are useful as fungicides, insecticides, nematicides or plant growth regulators.Type: GrantFiled: April 17, 1987Date of Patent: May 2, 1989Assignee: Imperial Chemical Industries PLCInventors: Vivienne M. Anthony, John M. Clough, Paul DeFraine, Christopher R. A. Godfrey, Patrick J. Crowley, Kenneth Anderton
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Patent number: 4824854Abstract: Novel fungicidal pyridyl iminocarbonates having the general structural formula ##STR1## wherein R is selected from the group consisting of C.sub.1 -C.sub.16 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 substituted alkenyl, C.sub.3 -C.sub.4 carboalkoxyalkyl, aryl, arylalkyl having C.sub.1 -C.sub.3 alkyl , substituted aryl and arylalkyl wherein the substituents are --Cl, --Br, --F and --NO.sub.2 ; furfuryl, pyridyl, C.sub.1 -C.sub.6 alkyl substituted phosphorus, alkanoyl, alkoxycarbonyl, aroyl, preferably benzoyl, alkylthioarbonyl, alkylthioalkyl, alkoxyalkyl, alkoxybenzyl and ##STR2## wherein R.sub.3 and R.sub.4 are C.sub.1 -C.sub.10 alkyl and can form a heterocyclic ring;R.sub.1 is selected from the group consisting of halogen, C.sub.1 --C.sub.3 alkoxy, C.sub.3 -C.sub.4 alkenyloxy and C.sub.1 --C.sub.3 haloalkoxy;R.sub.2 is selected from the group consisting of C.sub.1 -C.sub.Type: GrantFiled: October 29, 1987Date of Patent: April 25, 1989Assignee: ICI Americas Inc.Inventors: Don R. Baker, Keith H. Brownell
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Patent number: 4818426Abstract: A bleach precursor compound, its peroxygen acid derivative, and detergent compositions containing these materials are disclosed herein. The bleach precursor structurally comprises a quaternized ammonium or phosphonium group linked to a carbonate moiety having a leaving group. Upon perhydrolysis in the presence of hydrogen peroxide and a basic aqueous media, there is generated a peroxycarbonic acid bleach.Type: GrantFiled: March 30, 1988Date of Patent: April 4, 1989Assignee: Lever Brothers CompanyInventors: Robert W. R. Humphreys, Stephen A. Madison
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Patent number: 4818271Abstract: Pyridinylurea compounds of the formula ##STR1## and acid addition salts thereof; wherein R is cyclo alkyl, alkenyl, or an alkyl group optionally substituted with halogen, hydroxy, cycloalkyl, alkoxy, dialkylamino or phenyl; R.sup.1 is hydrogen or alkyl; R and R.sup.1 together with the nitrogen atom of the NRR.sup.1 group optionally define a heterocycle containing 4 to 6 ring carbon atoms; X is hydrogen, halogen, haloalkyl, alkoxy, alkylthio or alkylsulfonyl; Y is hydrogen, halogen, haloalkyl, alkoxy, alkylthio or alkylsulfonyl; and wherein the NHCONRR.sup.1 group is bonded to the pyridinyl ring in the 3- or 4-position; provided that at least one of X and Y is other than hydrogen and when both R and R.sup.1 are alkyl, R is 1,1-dimethylethyl or cyclopentyl and R.sup.1 is methyl. The compounds are useful in agriculture as plant growth regulators.Type: GrantFiled: October 31, 1985Date of Patent: April 4, 1989Assignee: FMC CorporationInventor: Robert N. Henrie, II
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Patent number: 4808600Abstract: Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula ##STR1## in which R is selected from the group halogen C.sub.1 -C.sub.3 alkoxy and C.sub.1 C.sub.3 haloalkoxy, R.sub.1 is selected from the group of --H and --C.tbd.N; and R.sub.2 is selected from the group of --H, 1--CH.sub.3 and 2--CH.sub.3 ; X is O or S; and fungicidal acceptable organic and inorganic salts thereof. These compounds provide excellent control of fungal growth.Type: GrantFiled: May 13, 1988Date of Patent: February 28, 1989Assignee: Stauffer Chemical Co.Inventors: Don R. Baker, Keith H. Brownell
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Patent number: 4808722Abstract: Pyridinylurea N-oxides of the formula ##STR1## and acid addition salts thereof; wherein R is cycloalkyl (C.sub.3 -C.sub.8), alkenyl (C.sub.3 -C.sub.8), or an alkyl (C.sub.1 -C.sub.6) group optionally substituted with halogen, hydroxy, cycloalkyl (C.sub.3 -C.sub.8) alkoxy (C.sub.1 -C.sub.6), dialkyl (C.sub.1 -C.sub.6)amino or phenyl; R.sup.1 is hydrogen or alkyl (C.sub.1 -C.sub.6); R and R.sup.1 together with the nitrogen atom of the NRR.sup.1 group optionally define a nonaromatic heterocycle containing 4 to 6 ring carbon atoms; each X independently is halogen, alkyl (C.sub.1 -C.sub.6), haloalkyl (C.sub.1 -C.sub.6), alkoxy (C.sub.1 -C.sub.6), hydroxy, 2-pyridinyl, alkyl(C.sub.1 -C.sub.6)thio or alkyl (C.sub.1 -C.sub.6)sulfonyl; A is 1 to 4; and wherein the NHCONRR.sup.1 group is bonded to the pyridinyl ring in the 3- or 4-position. The compounds are useful in agriculture as plant growth regulators.Type: GrantFiled: October 31, 1985Date of Patent: February 28, 1989Assignee: FMC CorporationInventor: Robert N. Henrie, II
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Patent number: 4800205Abstract: Novel fungicidal pyridyl sulfenyl carbamates having the formula ##STR1## wherein R is selected from the group consisting of haloalkyl, C.sub.1 -C.sub.8 alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, alkanoyl, alkylamino, arylamino, arylalkylamino and substituted pyridylcarbamoyl;R.sub.1 is C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 haloalkoxy or halomethoxy; alkenyloxy; and halogen;R.sub.2 is C.sub.1 -C.sub.3 alkyl;X is oxygen or sulfur; andY is oxygen or sulfurand fungicidally acceptable organic and inorganic salts thereof which are highly effective fungicides for use both as preventive and curative fungicides are disclosed herein.Type: GrantFiled: October 29, 1987Date of Patent: January 24, 1989Inventors: Don R. Baker, Francis H. Walker, Keith H. Brownell
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Patent number: 4798893Abstract: A method for the synthesis of the 2-propanone (I) is described starting from alkoxide (II) through the lactone (IV). ##STR1## Excellent control of the location of the substitution on the phenyl ring is achieved and the reaction proceeds in high yield.Type: GrantFiled: September 21, 1987Date of Patent: January 17, 1989Assignee: McNeilab, Inc.Inventors: David A. Cherry, Cynthia A. Maryanoff, John E. Mills, Roy A. Olofson, James D. Rodgers
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Patent number: 4797407Abstract: Novel fungicidal pyridyl carbamates having the formula ##STR1## wherein R is selected from the group consisting of halogen such as chlorine, fluorine and bromine, C.sub.1 -C.sub.3 alkoxy such as propoxy, ethoxy and methoxy, preferably methoxy, --CF.sub.3, C.sub.3 -C.sub.4 alkenyloxy and C.sub.1 -C.sub.3 haloalkoxy;R.sub.1 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, preferably methyl; C.sub.3 -C.sub.6 cycloalkyl, benzyl, C.sub.1 -C.sub.3 haloalkyl and C.sub.3 -C.sub.8 cyclic, straight or branched alkoxyalkyl;X is either oxygen or sulfur; Y is either oxygen or sulfur; and fungicidally acceptable organic and inorganic salts thereof. These compounds provide excellent control of fungal growth.Type: GrantFiled: October 29, 1987Date of Patent: January 10, 1989Assignee: ICI Americas Inc.Inventors: Don R. Baker, Keith H. Brownell
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Patent number: 4791123Abstract: There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A have the meanings given in the description, processes for their preparation and insecticidal and acaricidal compositions containing these compounds.Type: GrantFiled: January 22, 1987Date of Patent: December 13, 1988Assignee: Schering Akt.Inventors: Helga Franke, Heinrich Franke, Hans-Rudolf Kruger, Hartmut Joppien, Dietrich Baumert, David Giles
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Patent number: 4789395Abstract: Disclosed herein are compounds of the general formula ##STR1## which are useful as herbicides.Type: GrantFiled: May 12, 1986Date of Patent: December 6, 1988Assignee: Monsanto CompanyInventors: Len F. Lee, Kerry L. Spear, Mark G. Dolson
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Patent number: 4783535Abstract: A process for the preparation of 1,4-oxazepinones and thiones having the formula: ##STR1## wherein A is an aromatic ring selected from benzene, naphthalene, quinoline or pyridine; n is 1 to 3; Z is an amino radical; R is hydrogen, loweralkyl, cycloalkyl or phenylloweralkyl; and R.sup.4 and R.sup.5 are hydrogen and loweralkyl starting from chloroaromatic carboxylates and alkanolamines is disclosed. The oxazepinones and oxazepinethiones prepared by the process have utility as antihistaminics with low sedative potential. Novel intermediate compounds are also disclosed.Type: GrantFiled: March 18, 1986Date of Patent: November 8, 1988Assignee: A. H. Robins Company, IncorporatedInventors: Young S. Lo, Albert D. Cale, Jr.
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Patent number: 4767772Abstract: Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula ##STR1## wherein R is selected from the group consisting of cycloalkyl, preferably cyclopropyl, hydrogen, alkyl, haloalkyl, substituted alkyl, aryl, substituted aryl, heteroalkyl, alkenyl, OR.sub.1, SR.sub.1 and ##STR2## wherein n is 0-10, preferably 0-2, and R.sub.1 is C.sub.1 -R.sub.4 alkyl, and R.sub.2 is selected from the group consisting of halogen such as chlorine, fluorine and bromine, preferably chlorine, C.sub.1 -C.sub.3 alkoxy such as propoxyethoxy and methoxy, preferably methoxy and C.sub.1 -C.sub.3 haloalkoxy, R.sub.3 is selected from the group consisting of hydrogen and methyl, X is --O or --S and Y is --O or --S; and fungicidally acceptable organic and inorganic salts thereof which are highly effective fungicides for use both as preventive and curative fungicides are disclosed herein.Type: GrantFiled: April 15, 1987Date of Patent: August 30, 1988Assignee: Stauffer Chemical Co.Inventors: Don R. Baker, Charles Kezerian, Keith H. Brownell
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Patent number: 4766135Abstract: Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula ##STR1## wherein R is selected from the group consisting of haloalkyl, preferably C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.8 alkyl, aryl, substituted aryl, and arylalkyl wherein the preferred aryl is phenyl, the alkyl is C.sub.1 -C.sub.3 alkyl and the preferred substitutions are Cl, Br, F and nitro, alkanoyl, preferably C.sub.1 -C.sub.4 alkanoyl, ##STR2## wherein R.sub.3 and R.sub.4 can be alkyl, alkanoyl, alkoxycarbanoyl, benzyl pyridyl and substituted pyridyl, R.sub.1 is C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 haloalkoxy, preferably methoxy or halomethoxy and halogen wherein the halogen is chlorine, bromine or fluorine, R.sub.2 is hydrogen or methyl, and fungicidally acceptable organic and inorganic salts thereof which are highly effective fungicides for use both as preventive and curative fungicides are disclosed herein. These compounds provide excellent control of fungal growth.Type: GrantFiled: April 15, 1987Date of Patent: August 23, 1988Assignee: Stauffer Chemical Co.Inventors: Don R. Baker, Keith H. Brownell
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Patent number: 4766134Abstract: Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula ##STR1## in which R is selected from the group halogen C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 haloalkoxy, R.sub.1 is selected from the group of --H and --C.tbd.N; and R.sub.2 is selected from the group of --H, 1-CH.sub.3 and 2-CH.sub.3 ; X is O or S; and fungicidally acceptable organic and inorganic salts thereof. These compounds provide excellent control of fungal growth.Type: GrantFiled: April 15, 1987Date of Patent: August 23, 1988Assignee: Stauffer Chemical Co.Inventors: Don R. Baker, Keith H. Brownell
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Patent number: 4762848Abstract: Heterocyclic sulfides of the general formula heterocycle-S-R, a process for their preparation and, in particular, their use for immunostimulation, immunorestoration and cytostatic treatment, and pharmaceutical agents, which contain a sulfide of this type, for these indications.Type: GrantFiled: March 10, 1986Date of Patent: August 9, 1988Assignee: Hoechst AktiengesellschaftInventors: Karl-Heinz Scheunemann, Walter Durckheimer, Jurgen Blumbach, Michael Limbert, Hans-Ulrich Schorlemmer, Gerhard Dickneite, Hans-Harald Sedlacek
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Patent number: 4751015Abstract: A bleach precursor compound, its peroxygen acid derivative, and detergent compositions containing these materials are disclosed herein. The bleach precursor structurally comprises a quaternized ammonium or phosphonium group linked to a carbonate moiety having a leaving group. Upon perhydrolysis in the presence of hydrogen peroxide and a basic aqueous media, there is generated a peroxycarbonic acid bleach.Type: GrantFiled: March 17, 1987Date of Patent: June 14, 1988Assignee: Lever Brothers CompanyInventors: Robert W. Humphreys, Stephen A. Madison
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Patent number: 4730050Abstract: A derivative of a fibrinolytic enzyme in which the catalytic site on the enzyme which is responsible for fibrinolytic activity is blocked by a human protein attached thereto by way of a reversible linking group.Type: GrantFiled: April 3, 1987Date of Patent: March 8, 1988Assignee: Beecham Group p.l.c.Inventor: Richard A. G. Smith
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Patent number: 4677205Abstract: New chemical compounds having the generic formula: ##STR1## wherein X is one equivalent of an anion selected from the group consisting of monovalent or polyvalent anions, and having utility as incapacitating agents and in munitions.Type: GrantFiled: March 29, 1967Date of Patent: June 30, 1987Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Harold Z. Sommer, George E. Wicks, Jr.
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Patent number: 4675411Abstract: Novel toxic compounds being useful as chemical warfare agents in various itions.The compound having the following structure: ##STR1## where n is an integer from 6 to 16 and where X is halide, sulfate, nitrate, hydrogenoxalate or perchlorate forming a stable salt.Type: GrantFiled: June 10, 1966Date of Patent: June 23, 1987Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Harold Z. Sommer, Jacob I. Miller
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Patent number: 4672122Abstract: New chemical compounds having the generic formula: ##STR1## wherein X is one equivalent of a monovalent or polyvalent anion; R and R' re methyl or ethyl radicals; R.sub.1, R.sub.1 ', R.sub.2, R.sub.2 ' are hydrogen or a methyl radical; and Z is a radical selected from methyl, ethyl, propyl, butyl, or pentyl and having utility as incapacitating agents and in munitions.Type: GrantFiled: January 21, 1972Date of Patent: June 9, 1987Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Harold Z. Sommer, George E. Wicks, Jr.
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Patent number: 4672124Abstract: New chemical compounds, bis quaternary carbamates, having the generic fora: ##STR1## wherein X is one equivalent of an anion selected from monovalent or polyvalent anions, wherein n is 1 to 8, and wherein R, R' are aliphatic radicals selected from the group consisting of methyl, ethyl, propyl, and butyl, and having utility as toxic agents.Type: GrantFiled: August 2, 1967Date of Patent: June 9, 1987Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Harold Z. Sommer, George E. Wicks, Jr.
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Patent number: 4672123Abstract: New chemical compounds having the generic formula: ##STR1## wherein X is one equivalent of an anion selected from monovalent and pollent anions, and R,R' and Z are aliphatic radicals selected from the group consisting of ethyl, propyl, and butyl, with the provision that when Z is a radical selected from the group of octyl, dodecyl, and cyclohexyl, R,R' are selected from methyl and ethyl groups, and having utility as incapacitating agents and in munitions.Type: GrantFiled: April 28, 1967Date of Patent: June 9, 1987Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Harold Z. Sommer, George E. Wicks, Jr.
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Patent number: 4666927Abstract: Compounds in which two or more rings, being a 3-hydroxypypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.Type: GrantFiled: September 18, 1984Date of Patent: May 19, 1987Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4661502Abstract: Anticholinesterase and antihypercholesterolemic pyridine derivatives of the formula (I) ##STR1## are provided as well as processes for preparing same, and composition and methods of treatment employing such pyridine derivatives as the active drug components thereof.Type: GrantFiled: February 10, 1984Date of Patent: April 28, 1987Assignee: Otsuka Pharmaceutical Co. Ltd.Inventors: Nicholas S. Bodor, Yasuo Ohshiro
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Patent number: 4655816Abstract: There are disclosed novel 2,6-substituted-3-pyridinecarboxylic acids, esters, and salts useful as herbicides, and as intermediates which provide herbicides.Type: GrantFiled: August 27, 1985Date of Patent: April 7, 1987Assignee: Monsanto CompanyInventors: Len F. Lee, Maria L. Miller
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Patent number: 4647569Abstract: Pyridylaminoethene derivatives of the formula: ##STR1## wherein R.sup.1 is pyridyl, unsubstituted or substituted by one or more substituents R.sup.4 selected from halogen, amino, carboxy, cyano nitro, hydroxy, formyl, trifluoromethyl, aryl, aryloxy, arylthio, benzyloxycarbonylamino, sulphamoyl, tetrazol-5-yl, carbamoyl, thiocarbamoyl, arylcarbamoyl, aroyl, alkyl, alkoxy, alkylthio, alkylsulphonyl, alkylamino, alkylsulphamoyl, arylalkyl, alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl, alkanoylamino, N-benzyloxycarbonyl-N-alkylamino, or dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl, wherein the alkyl groups may together form a ring, and R.sup.2 and R.sup.3 each represents phenyl, unsubstituted or substituted by one or more substituents R.sup.4 as hereinbefore defined, possess antiarthritic properties.Type: GrantFiled: September 19, 1985Date of Patent: March 3, 1987Assignee: May & Baker LimitedInventors: Raymond F. Collins, Philip Knowles, Libert C. Saunders, Francis J. Tierney, Peter J. Warne
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Patent number: 4608081Abstract: Novel compounds in the form of 2-[4-(4-cyanophenoxy)-phenoxy]-propionic or acetic acid amide derivatives and selective herbicides containing the same as an active ingredient.Type: GrantFiled: June 22, 1984Date of Patent: August 26, 1986Assignees: Kanesho Company Limited, Toyo Soda Manufacturing Company LimitedInventors: Shinzo Someya, Rokuro Akahira, Yuji Nonaka, Akira Nakanishi, Mikio Ito
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Patent number: 4602944Abstract: Herbicidally-active compounds of the formula: ##STR1## where: Y represents halo or trifluoromethyl;Z represents hydrogen, halo, trifluoromethyl or nitro;A represents --N.dbd. or ##STR2## where X is as defined above for Z; and R represents --N.sup.- Q.sup.+ or --NH--Q.sup.+ An.sup.- where Q.sup.+ is a quaternized heterocyclic group bonded through a nitrogen atom thereof, and An.sup.- is a suitable anion,methods for their preparation and compositions containing them.Type: GrantFiled: September 27, 1984Date of Patent: July 29, 1986Assignee: FBC LimitedInventor: Peter J. West
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Patent number: 4594352Abstract: There are described compounds of formula: ##STR1## in which one of R and R.sup.1 is F or Cl and the other is H, F or Cl;X is a 1,4-phenylene or pyridyl bound in positions 2 and 5, optionally substituted;Y is a phenyl, 2- or 3-pyridyl, optionally substituted.The compounds of formula I are endowed with a high insecticide activity which is mainly directed against insect larvae and eggs.Type: GrantFiled: April 19, 1984Date of Patent: June 10, 1986Assignee: Montedison S.p.A.Inventors: Pietro Massardo, Franco Bettarini, Gabriele Giovarruscio, Paolo Piccardi, Franca Reggiori, Vincenzo Caprioli, Angelo Longoni
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Patent number: 4581365Abstract: The invention relates to new trichloroacryloyl oxime compounds of the general formula (I) ##STR1## wherein each of R.sup.1 and R.sup.2 represents a hydrogen atom, a lower alkyl group, a benzyl group, a benzylthio group, a lower alkylthio group, a cycloalkyl group, a halogen atom, a styryl group, a halogenophenylthio group, a naphthyl group, or a phenyl group which may optionally be substituted by at least one substituent selected from the class consisting of a halogen atom, a nitro group, a lower alkyl group, a lower alkoxy group, a phenoxy group, a benzyloxy group, a lower alkylthio group, a thiocyanato group, a di-lower alkylamino group, a halogenopyridyloxy group and a methylenedioxy group, or R.sup.1 and R.sup.2, together with the carbon atom to which they are bonded, may form an aliphatic ring, said ring being optionally substituted by at least one methyl group, and their use as fungicides.Type: GrantFiled: December 2, 1983Date of Patent: April 8, 1986Assignee: Nihon Tokushu Noyaku Seizo K.K.Inventors: Yasuo Yamada, Junichi Saito, Toshio Gotoh, Osamu Katsumata, Shinji Sakawa
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Patent number: 4568751Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.Type: GrantFiled: April 29, 1983Date of Patent: February 4, 1986Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
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Patent number: 4560762Abstract: 2-Alkylaminopyridine derivatives represented by a general formula of ##STR1## wherein R denotes a lower alkyl group and Y denotes a methoxy group or a halogen atom, and method for producing the same.Type: GrantFiled: May 23, 1983Date of Patent: December 24, 1985Assignee: Toyo Soda Manufacturing Co. Ltd.Inventors: Kenji Tsuzuki, Hideo Morinaka
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Patent number: 4558155Abstract: N-(Aryloxyalkyl)-N'-(aminoalkyl)ureas and thioureas having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen, loweralkyl, cycloalkyl, phenyl or phenyllower alkyl, and R.sup.3 and R.sup.4 are hydrogen, loweralkyl, phenyl and phenylalkyl or R.sup.3 and R.sup.4 taken together with the adjacent nitrogen form a heterocyclic residue are disclosed in a method of suppressing cardiac arrhythmias.Type: GrantFiled: November 13, 1984Date of Patent: December 10, 1985Assignee: A. H. Robins Company, IncorporatedInventors: James R. Shanklin, Jr., Christopher P. Johnson, III
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Patent number: 4547218Abstract: Novel compounds having a pyridinyl radical positioned adjacent to the propanoic acid portion, e.g., ethyl 2-((6-(2-chloro-4-(trifluoromethyl)-phenoxy)-3-nitro-2-pyridinyl)oxy)propi onate, which are selective herbicides useful for controlling weeds in valuable crops.Type: GrantFiled: October 7, 1983Date of Patent: October 15, 1985Assignee: The Dow Chemical CompanyInventors: Sudarshan K. Malhotra, B. Clifford Gerwick, III
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Patent number: 4530842Abstract: The compounds of formula I ##STR1## wherein R, R.sub.1 and R.sub.2 have various significances, are useful as agents against heart insufficiency.Type: GrantFiled: May 12, 1983Date of Patent: July 23, 1985Assignee: Sandoz Ltd.Inventor: Gerhard Bormann
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Patent number: 4447256Abstract: N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids represented by the formula: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is independently hydrogen or lower alkyl, and each of X and Y is independently hydrogen, halogen, nitro, acetamino, carboxyl, lower alkyl, methoxycarbonyl, hydroxyl or methoxy,and salts thereof, have effective herbicidal effects on postemergence of plants and selective inactivity against cotton plants.Type: GrantFiled: July 29, 1980Date of Patent: May 8, 1984Assignee: Nissan Chemical Industries, Ltd.Inventors: Fumio Suzuki, Yoshihiro Fujikawa, Susumu Yamamoto, Hidemi Mizutani, Tunehiko Ohya, Takashi Ikai, Toshihiko Oguchi
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Patent number: 4436911Abstract: This invention relates to a novel class of heterocyclic amidinourea and heterocylic amidinothiourea compounds wherein the heterocyclic substitution is at the 1-N urea nitrogen atom. These compounds exhibit pharmaceutical activity and may be incorporated into pharmaceutical preparations for producing anti-ulcerogenic, antisecretory, antispasmodic, antimotility, cardiovascular, antidiarrheal or antiparasitic action.Type: GrantFiled: May 12, 1981Date of Patent: March 13, 1984Assignee: William H. Rorer, Inc.Inventors: William L. Studt, Harry K. Zimmerman, George H. Douglas
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Patent number: 4435207Abstract: Oxime ester compounds of the formula ##STR1## wherein A is one of the groups ##STR2## wherein B is --CH.dbd. or nitrogen and R.sub.1 is one of the groups ##STR3## wherein R.sub.2 -R.sub.7, m and n are as hereinafter set forth, processes for their preparation, herbicidal compositions containing these compounds as the active ingredient and methods of use of the herbicidal compositions are disclosed.Type: GrantFiled: November 23, 1981Date of Patent: March 6, 1984Assignee: Hoffmann-La Roche Inc.Inventors: Georg Frater, Milos Suchy, Jean Wenger, Paul Winternitz
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Patent number: 4432994Abstract: Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are described. Methods of making the compounds, and novel intermediates, are also described.Type: GrantFiled: February 10, 1982Date of Patent: February 21, 1984Assignee: The Boots CompanyInventors: David P. Giles, John C. Kerry, Antonin Kozlik, Bryan H. Palmer, Stephen W. Shutler, Robert J. Willis
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Patent number: 4419363Abstract: Novel 1-aryloxy-3-amidoamidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. Representative of the compounds disclosed is 1-(o-cyanophenoxy)-3-.beta.-(2-thenamidoacetamido)ethylaminopropan-2-ol.Type: GrantFiled: June 4, 1982Date of Patent: December 6, 1983Assignee: Imperial Chemical Industries PLCInventor: Leslie H. Smith
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Patent number: 4418198Abstract: The invention is directed to the novel 2-(((substituted pyridinyl)carbonyl)amino)ethyl esters of 2-methyl-2-propenoic acid and their method of preparation. The compounds are prepared by reacting an appropriately substituted pyridinol, pyridinethiol, aminopyridine, or hydroxyalkyloxypyridine with isocyanatoethyl methacrylate in an appropriate solvent in the presence of an activating agent. These compounds may be utilized as herbicides, fungicides, or both.Type: GrantFiled: November 16, 1981Date of Patent: November 29, 1983Assignee: The Dow Chemical CompanyInventor: Chester E. Pawloski
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Patent number: 4412856Abstract: The novel compounds of the formula I are useful selective herbicides for postemergence application in crops of cereals, maize and rice.In formula I, ##STR1## A is an unsubstituted or substituted amino group, Q is a C.sub.2 -C.sub.6 alkylene bridge, Y is an oxygen or sulfur atom or an unsubstituted or substituted nitrogen atom, and Z is an unsubstituted or substituted phenyl, naphthyl or heterocyclic radical, which phenyl radical, containing the bridge member Y, can additionally carry one to four further substituents.Type: GrantFiled: May 22, 1981Date of Patent: November 1, 1983Assignee: Ciba-Geigy CorporationInventors: Hans-Georg Brunner, Rolf Schurter, Henry Szczepanski
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Patent number: 4379785Abstract: What are disclosed are sulfonyl ureas of the formula ##STR1## in which R.sup.1, X and Y are as defined in the specification, and their physiologically acceptable salts, pharmaceutical formulations on the basis of these compounds, and their use in the treatment of diabetes.Type: GrantFiled: December 17, 1980Date of Patent: April 12, 1983Assignee: Hoechst AktiengesellschaftInventors: Rudi Weyer, Volker Hitzel, Karl Geisen, Gunter Regitz