Stabilized Alkenyl Pyridines Patents (Class 546/351)
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Patent number: 6797805Abstract: Organic polymers having water contact angles of 20° or smaller, preferably 7° or smaller and equipped with both high wettability and high transparency. The organic polymers may contain as partial structures polar structures of about 3 debyes or higher in dipole moment and are available especially from polymerization of polymerizable compounds having alkylene(thio)urea structures.Type: GrantFiled: June 28, 2002Date of Patent: September 28, 2004Assignee: Mitsui Chemicals, Inc.Inventors: Koju Okazaki, Ryouichi Seki, Shiro Nakatsuka
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Publication number: 20030166808Abstract: Organic polymers having water contact angles of 20° or smaller, preferably 7° or smaller and equipped with both high wettability and high transparency. The organic polymers may contain as partial structures polar structures of about 3 debyes or higher in dipole moment and are available especially from polymerization of polymerizable compounds having alkylene(thio)urea structures.Type: ApplicationFiled: June 28, 2002Publication date: September 4, 2003Inventors: Koju Okazaki, Ryouichi Seki, Shiro Nakatsuka
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Patent number: 6372693Abstract: The invention relates to 2-(3-alkenylbenzoyl)cyclohexane-1,3-diones of the formula I where the variables have the following meanings: R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, —OR6, —OCOR7, —OSO2R7, —SH, —S(O)nR8, —SO2OR6, —SO2NR6R9, —NR9SO2R7 or —NR9COR7; R3 is hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl; R4, R5 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, alkoxy, alkylthio, haloalkoxy, —COR10, —CO2R10, —COSR10, —CONR10R11, —C(R12)═NR13, —PO(OR10)(OR11); unsubstituted or substituted alkyl, heterocyclyl, heterocyclylalkyl, phenyl, phenylalkyl, hetaryl or hetarylalkyl; or R4 and R5 together form an alkanediyl chain which can be substituted and/or can be interrupted by a hetero atom; Q is an unsubstituted or substituted cyclohexane-1,3-dione ring whType: GrantFiled: November 2, 1999Date of Patent: April 16, 2002Assignee: BASF AktiengesellschaftInventors: Ernst Baumann, Wolfgang von Deyn, Stefan Engel, Regina Luise Hill, Uwe Kardorff, Guido Mayer, Martina Otten, Michael Rack, Joachim Rheinheimer, Matthias Witschel, Karl-Otto Westphalen, Ulf Misslitz, Helmut Walter
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Patent number: 6197966Abstract: A method for producing an optically active amino alcohol compound of the formula [3], an enantiomer thereof or a salt thereof, comprising reacting a mesoepoxide compound of the formula [1] with a compound of the formula [2] in the presence of a mixed catalyst comprising a Lewis acid and a proton donor: wherein R1, R2 and R3 are each H, an optionally substituted lower alky, and the like, or R1 and R1 or R2 and R3 may form an optionally substituted ring; and R4 and R5 are each H, an optionally substituted lower alkyl, and the like, or R4 and R5 may form an optionally substituted ring together with the adjacent N, or an imide group or azide group together with the adjacent N, and R6 is H or a silyl group. The present invention enables stereoselective production of a desired intermediate compound, which is an HIV protease inhibitor, extremely efficiently as compared to conventional methods.Type: GrantFiled: January 15, 1999Date of Patent: March 6, 2001Assignees: Japan Tobacco Inc., Agouron Pharmaceuticals, Inc.Inventors: Takashi Inaba, Shoichi Sagawa, Hiroyuki Abe
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Patent number: 6030803Abstract: Dibenzodihydropyridinecarboxylic esters are provided which comply with formula (1) or (2), wherein: R.sub.1 is substituted alkyl or cyano; R.sub.2 and R.sub.3 are independently hydrogen, alkyl, substituted alkyl, aryl or substituted aryl; R.sub.4 is hydrogen, alkyl, substituted alkyl, aryl or substituted aryl; R.sub.5 and R.sub.6 are independently alkyl, alkoxy or another substituent which is relatively resistant to oxidation; m and n are integers from 0 to 4; wherein, if m or n is at least 2, two groups R.sub.5 or R.sub.6 may be linked together; and Z is oxygen or sulphur. The new compounds are used in a method as chemiluminogenic reagents for detecting the presence of peroxidase activity at extremely low levels (10.sub.-20 moles). A kit containing the dibenzodihydropyridine-carboxylic esters for use in assaying peroxidase activity has also been described.Type: GrantFiled: January 7, 1999Date of Patent: February 29, 2000Assignee: De Staat der Nederlanden, vertegenwoordigd door de Minister van Welzijn, Volksgeszonheid en CultuurInventors: Marjorie Jacquemijns, Gijsbert Zomer
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Patent number: 6008364Abstract: There is provided a process for producing an alkenyl-substituted pyridine derivative using, a solid base catalyst which is obtained by heating a metal oxide selected from the group consisting of alumina, an alkaline earth metal oxide and a hydrotalcite withan alkali metal,an alkali compound and an alkali metal oran alkali compound and an alkali metal hydride under an inert gas atmosphere at a temperature within the range of 100-700.degree. C.Type: GrantFiled: July 10, 1998Date of Patent: December 28, 1999Assignee: Sumitomo Chemical Company, LimitedInventors: Michio Yamamoto, Gohfu Suzukamo
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Patent number: 5674883Abstract: Products of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent:--a hydrogen atom, a halogen atom, one of the following radicals: hydroxyl, mercapto, cyano, nitro, sulpho, formyl, benzoyl, acyl, carboxy, cycloalkyl, acyloxy,--an alkyl, alkenyl, alkynyl, alkyloxy or alkythio radical,--an alkyl, alkenyl, alkynyl, alkyloxy or alkylthio radical,--an aryl, arylalkyl, arylalkenyl, aryloxy or arylthio radical,--a radical: ##STR2## --a--(CH.sub.2).sub.m1 --S(O).sub.m2 --Z'--R'.sub.14 radical in which m1 represents an integer from 0 to 4, m2 represents an integer from 0 to 2, R.sub.5 represents a divalent alkylene radical, Y represents the --Y.sub.1 --B--Y.sub.2 radical.These products have useful pharmacological properties, which justify their use as medicaments.Type: GrantFiled: July 31, 1996Date of Patent: October 7, 1997Assignee: Roussel UclafInventors: Michel Fortin, Jean Luc Haesslein, Bertrand Heckmann
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Patent number: 4898455Abstract: There is described compounds of the formula ##STR1## wherein X stands for CH and Y stands for N or X stands for N and Y stands for CH; A.sup.1 and A.sup.2 signify single covalent bonds or one of the groups A.sup.1 and A.sub.2 also signifies trans-1,4-cyclohexylene, cis-4-cyano-trans-1,4-cyclohexylene or 1,4-phenylene optionally substituted with halogen or methyl; ring B represents trans-1,4-cyclohexylene, 1,4-phenylene optionally substituted with halogen or methyl or, when A.sup.2 signifies a single covalent bond, also cis-4-cyano-trans-1,4-cyclohexylene; R.sup.1 denotes an optionally halogen-substituted alkyl or alkenyl group in which optionally one CH.sub.2 group or two non-adjacent CH.sub.2 groups is/are replaced by --O--, --COO-- and/or --OOC--; R.sup.2 signifies an optionally halogen-substituted alkyl or alkenyl group in which optionally one CH.sub.2 group or two non-adjacent CH.sub.2 groups is/are replaced by --O--, --COO-- and/or --OOC-- or R.sup.Type: GrantFiled: April 16, 1987Date of Patent: February 6, 1990Assignee: Hoffmann-La Roche Inc.Inventors: Richard Buchecker, Alfred Germann, Stephen Kelly, Martin Schadt
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Patent number: 4552880Abstract: This invention relates to certain substituted aroylimidazolones, their acid and base addition salts thereof, and to their use as cardiotonic agents.Type: GrantFiled: December 21, 1983Date of Patent: November 12, 1985Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Richard C. Dage, Richard A. Schnettler