Abstract: Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

Abstract: Product, method of making product, and technique for using product to separate oil from water via a filter, such as cotton, polyester, or leather, coated with a chemical that blocks oil while allowing water to pass therethrough.

Abstract: A process recovers of pyridine and/or its derivatives from their aqueous mass and/or manufacturing reaction mass by liquid-liquid extraction employing an alkyl acetate. The process further involves effective recovering and recycling of solvents from the aqueous phase and other waste obtained during the process.

Abstract: A method of purifying crude pyridine on an industrial scale at low cost and in a simple manner is provided. More specifically, a pyridine purification method including subjecting crude pyridine to an alkali treatment and then to distillation, or a pyridine purification method including adding an acid or water to crude pyridine, and subjecting the resulting mixture to an alkali treatment and then to distillation is provided. According to the purification method of the present invention, crude pyridine can be purified on an industrial scale at low cost and in a simple manner. Moreover, the pyridine purified by this method is useful as a starting material for various organic syntheses because of its high purity. For example, the pyridine can be reacted with chlorine to produce a chlorinated pyridine in a high yield.

Abstract: Disclosed herein is a process for recovery of pyridine and/or its derivatives from their aqueous mass and/or manufacturing reaction mass by liquid-liquid extraction employing an environmentally non-hazardous organic solvent. The process further comprising effective recovering and recycle of solvents from the aqueous phase and the other waste obtained during the process.

Abstract: The present invention relates to a method of continuously separating pyridine or pyridine derivatives from aqueous solutions by extraction, wherein supercritical fluid is employed to extract the pyridine material from liquid media. The method of the invention, in particular, extracts pyridine or pyridine derivatives from aqueous solutions with pressurized carbon dioxide, which is used under pressure, or in the liquid state, or in the near critical state or in the supercritical state. The operating system is a continuously operating extraction system, so that a part, or all, of the pyridine and/or pyridine derivatives are transferred from the aqueous phase to the carbon dioxide phase, and thereafter the aqueous phase and carbon dioxide phase are separated from each other; and the pyridine and/or pyridine derivatives are separated from carbon dioxide; and the extract containing pyridine and/or pyridine derivatives is thereby obtained.

Abstract: The deazauracil containing probes of the invention are able to withstand higher temperatures, thereby allowing unmatched probes and mismatched probes to be washed off at higher hybridization stringency, thereby eliminating background readings and improving ease and accuracy of probe use.

Abstract: The invention relates to optically active homo- and copolymers made from optically active (meth)acrylamides, the polymers being immobilized on silica gel, a process for their preparation, and their use as adsorbents, in particular as the stationary phase for chromatographic racemate resolution.

Abstract: A method of preparing UV-grade synthetic pyridine from a pyridine-containing reaction product mixture which also contains at least one other compound which is UV absorbing to a sufficient extent that said pyridine mixture is not UV grade, said mixture being obtained from the condensation reaction, over an effective catalyst, of one of more aldehydes and/or ketones with one or more amines and/or ammonia, comprises recovering from said mixture a pyridine-water azeotrope effective to separate pyridine therefrom sufficiently free of UV-absorbing compounds to be UV grade.

Abstract: In a countercurrent extraction process for extracting at least one alkylpyridine (preferably 2-methyl-5-ethylpyridine) from a liquid feed stream also comprising at least one alkylenepyridine (preferably 2-methyl-5-vinylpyridine) by means of an aqueous acid solution (preferably aqueous H.sub.2 SO.sub.4), the improvement comprises the presence of a gas stream, preferably flowing in the same direction as the liquid feed stream.

Abstract: Aqueous solutions which are obtained in the carbalkoxylation of olefinically unsaturated compounds and contain heterocyclic aromatic nitrogen bases, their transformation products and lower fatty acids and/or their salts are treated by a process in which (a) the aqueous solution is heated to 150.degree.-300.degree. C. under from 10 to 300 bar and (b) heterocyclic aromatic nitrogen bases which are formed again from the transformation products are then separated off.

Abstract: Pyridine or methylpyridines or mixtures thereof are recovered from methyl butanedicarboxylate containing reaction mixtures obtained by reaction of methyl pentenoate with carbon monoxide and methanol in the presence of pyridine, methylpyridines or mixtures thereof and also cobalt catalysts at elevated temperatures and under superatmospheric pressure and subsequent treatment with molecular oxygen containing gases in aqueous acetic acid by(a) separating the reaction mixture on the one hand into an aqueous phase containing cobalt acetate, pyridine, methylpyridines or mixtures thereof, acetic acid and methanol and on the other an organic phase containing methyl butanedicarboxylate, by-products, unconverted methyl pentenoate, acetic acid and also pyridine, methylpyridines or mixtures thereof,(b) extracting the organic phase obtained in step (a) with aqueous acetic acid to obtain an aqueous extract containing pyridine or methylpyridines or mixtures thereof as well as acetic acid,(c) combining the aqueous extract obt

Abstract: A process for separating alpha or gamma-picoline from a feed mixture comprising alpha-picoline or gamma-picoline and at least one other picoline isomer from which the alpha or gamma isomer is to be separated. The feed mixture is contacted at adsorption conditions with an adsorbent comprising a type Y zeolite having alkaline earth or iron group cations at exchangeable cationic sites, which exclude the alpha isomer, or with a potassium exchanged type X zeolite or calcium exchanged type Y zeolite which are selective for the gamma isomer. The high purity alpha or gamma isomer is recovered as a raffinate or extract product, respectively. Pyridine is a preferred desorbent material.

Abstract: Methylnaphthalenes, indole and other tar bases are recovered from a base-extracted coal tar distillation fraction. In one form, an aqueous salt solution of pH 0.5-3 extracts other tar bases from the starting material, and thereafter both products are recovered from the raffinate by several alternate methods including ethylene glycol extraction and extractive distillation. In other forms, the starting material is extracted with ethylene glycol and the extract is distilled to recover several products including indole. The raffinate of ethylene glycol extraction contains methylnaphthalenes and other hydrocarbons and can be purified to solvent-grade material.

Abstract: Isothiochromans are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.