Hexacyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos Patents (Class 546/38)
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Patent number: 7307170Abstract: The epindolidione compounds of the general formula (I) in which A?, R2 and A have the meanings given in claim 1, are outstanding pigments which are notable in particular for better migration, light and solvent fastnesses, better heat stability and enhanced colouring power and also better dispersibility and capability to be brought into pigment form. The invention also relates to a process for preparing these epindolidione compounds and to their use a colorants for colouring polymer compositions or paper pulps, as colorants in electrophotographic toners and developers, as colorants in ink-jet inks, as colorants in the coatings industry, as colorants for textile printing or as a printing ink in the graphical industry, as colorants in cosmetics.Type: GrantFiled: February 6, 2002Date of Patent: December 11, 2007Assignee: Clariant Finance (BVI) LimitedInventors: Bansi Lal Kaul, Bruno Piastra, Valérie Wolf, Frank Prokschy, Martin Ulrich Schmidt
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Patent number: 7115743Abstract: The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204.Type: GrantFiled: December 10, 2004Date of Patent: October 3, 2006Assignee: Pharma Mar, S.A.Inventors: Kenneth L. Rinehart, Jose J. Morales, Joel Reid, Isabel Reymundo, Pablo Floriano, Lola Garcia Gravalos
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Patent number: 6986811Abstract: The present invention relates to substituted perylene derivatives in which the substituent has a sterically stabilizing and/or electrostatically stabilizing effect. The perylene derivatives of the invention are particularly suitable as pigment dispersants. The present invention additionally relates to pigment preparations in which the perylene derivatives of the invention are used.Type: GrantFiled: January 20, 2004Date of Patent: January 17, 2006Assignee: BASF AktiengesellschaftInventors: Martin Könemann, Ulrike Hees, Valerie Pierre
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Patent number: 6916982Abstract: The present invention provides methods, compounds, and compositions for the synthesis of light harvesting arrays, such arrays comprising: (a) a first substrate comprising a first electrode; and (b) a layer of light harvesting rods electrically coupled to said first electrode, each of said light harvesting rods comprising a polymer of Formula I: X1?Xm+1)m??(I) wherein m is at least 1; X1 is a charge separation group, and X2 through Xm+1 are chromophores. At least one of X2 through Xm+1 has at least one perylene group coupled thereto.Type: GrantFiled: June 6, 2002Date of Patent: July 12, 2005Assignee: North Carolina State UniversityInventors: Robert S. Loewe, Kin-ya Tomizaki, Jonathan S. Lindsey
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Patent number: 6890377Abstract: Rylene dyes of the general formula I where R is hydrogen; unsubstituted or substituted C1-C30-alkyl, aryl or hetaryl; R? is unsubstituted or substituted C2-C30-alkyl or C5-C8-cycloalkyl, or substituted methyl; n is 0 or 1, their preparation and use for coloring high-molecular-weight organic and inorganic materials, and aminorylene-3,4-dicarboximide of the formula IV as their intermediates.Type: GrantFiled: February 14, 2002Date of Patent: May 10, 2005Assignees: BASF Aktiengesellschaft, Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Arno Böhm, Matthias Krieger, Stefan Becker, Klaus Müllen
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Patent number: 6838584Abstract: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.Type: GrantFiled: May 6, 2002Date of Patent: January 4, 2005Assignee: Merck & Co., Inc.Inventors: Timothy Allen Blizzard, Milton Lloyd Hammond, Jerry Dwain Morgan, Ralph Troy Mosley
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Publication number: 20040266803Abstract: Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.Type: ApplicationFiled: June 27, 2003Publication date: December 30, 2004Applicant: Research Triangle InsituteInventors: Mansukh C. Wani, Govindarajan Manikumar, Monroe E. Wall, Michael A. Wall
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Publication number: 20040266804Abstract: Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.Type: ApplicationFiled: June 30, 2003Publication date: December 30, 2004Applicant: Research Triangle InstituteInventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Michael A. Wall
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Publication number: 20040266753Abstract: A compound selected from those of formula (I): 1Type: ApplicationFiled: June 18, 2004Publication date: December 30, 2004Inventors: Michel Koch, Francois Tillequin, Sylvie Michel, John Hickman, Alain Pierre, Stephane Leonce, Bruno Pfeiffer, Pierre Renard
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Publication number: 20040194665Abstract: The present invention relates to substituted perylene derivatives in which the substituent has a sterically stabilizing and/or electrostatically stabilizing effect. The perylene derivatives of the invention are particularly suitable as pigment dispersants. The present invention additionally relates to pigment preparations in which the perylene derivatives of the invention are used.Type: ApplicationFiled: January 20, 2004Publication date: October 7, 2004Applicant: BASF AktiengesellschaftInventors: Martin Konemann, Ulrike Hees, Valerie Pierre
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Publication number: 20030216419Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.Type: ApplicationFiled: April 24, 2003Publication date: November 20, 2003Applicant: Cephalon, Inc.Inventor: Robert L. Hudkins
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Patent number: 6559306Abstract: This invention relates to new fluorescent or non-fluorescent dye compounds having a terminal hydroxy, carboxylic acid/ester or amino group and a process for their preparation. The new fluorescent or non-fluorescent dye compounds are useful as colorants for preparing colored synthetic polymer resins with pigmentary properties, for dyeing or printing homo- or mixed synthetic, semi-synthetic or natural polymers or substrates or for preparing inks. The dye compounds provide excellent properties, especially high temperature stability and easy applicability.Type: GrantFiled: July 13, 2001Date of Patent: May 6, 2003Assignee: Clariant Finance (BVI) LimitedInventors: Bansi Lal Kaul, Jean-Christophe Graciet
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Patent number: 6486319Abstract: The invention relates to rylene dyes of the general formula (I), wherein the variables have the following meanings: R represents hydrogen; optionally substituted C1-C30 alkyl-C5-C8-cycloalkyl, aryl or hetaryl; R′ represents optionally substituted C2-C30 alkyl or C5-C8 cycloalkyl, substituted methyl; and n is 0 or 1. The invention also relates to the preparation and use of said dyes for coloring highly molecular organic and inorganic materials and to 9-amino-perylene-3,4-dicarboxylic acid imides (Va) as their intermediate products.Type: GrantFiled: February 27, 2002Date of Patent: November 26, 2002Assignees: BASF Aktiengesellschaft, Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Arno Böhm, Heinrich Schmeisser, Stefan Becker, Klaus Müllen
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Patent number: 6383666Abstract: Disclosed are new organometallic complex molecules having light-emitting and electron-transporting characteristics. Also disclosed is organic EL (electroluminescent) devices using these organometallic complex molecules as electron-transporting materials. The organometallic complex molecules are used to form a light-emitting layer with or without doping of another light-emitting material. The organometallic complex molecules can also be used in an electron-transporting layer of the organic EL device. The organic EL devices incorporating the organometallic complex molecules have high thermal stability.Type: GrantFiled: March 31, 2000Date of Patent: May 7, 2002Assignee: LG Chem, Ltd.Inventors: Kongkyeom Kim, Sehwan Son, Okhee Kim, Seok-Hee Yoon, Hyo-Seok Kim, Jaesoon Bae, Youn-Gu Lee
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Publication number: 20010034446Abstract: Disclosed are a process for the preparation of a compound represented by the formula (1), which comprises treating a compound represented by the formula (2) with methanesulfonic acid and then subjecting the thus-treated compound to recrystallization; and Compound (1) so obtained.Type: ApplicationFiled: June 11, 2001Publication date: October 25, 2001Applicant: DAIICHI PHARMACEUTICAL CO., LTD.Inventors: Shinji Kaminhara, Kazuaki Kanai, Shigeru Noguchi, Hirofumi Terasawa, Hiroaki Kitaoka
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Patent number: 6274728Abstract: Compounds of formula A(B)x (I), wherein x is an integer from 1 to 8, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, indanthrone, isoindolinone, isoindoline, dioxazine, azo, phthalocyanine or diketopyrrolopyrrole series that is bonded to x groups B via one or more hetero atoms, those hetero atoms being selected from the group consisting of N, O and S and forming part of the radical A, each group B independently of any other(s) is hydrogen or a group of the formula at least one group B being a group of the formula The compounds according to the invention are used in high-molecular-weight organic materials, thermo-, photo- or chemo-sensitive recording materials, light-sensitive negative or positive resist compositions, ink compositions for ink-jet printing and color tapes for thermal transfer printing.Type: GrantFiled: December 16, 1999Date of Patent: August 14, 2001Assignee: Ciba Specialty Chemicals Corp.Inventors: Véronique Hall-Goulle, Aline Bize
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Patent number: 6124458Abstract: Quaterrylenetetracarboxylic diimides I whereR is hydrogen;C.sub.1 -C.sub.30 -alkyl whose carbon chain may be interrupted by one or more of --O--, --S--, --NR.sup.1 --, --CO-- and/or --SO.sub.2 -- and which may be monosubstituted or polysubstituted by cyano, C.sub.1 -C.sub.6 -alkoxy or a 5-, 6- or 7-membered heterocyclic radical which is attached via a nitrogen atom and which may contain further heteroatoms and may be aromatic, whereR.sup.1 is hydrogen or C.sub.1 -C.sub.6 -alkyl;C.sub.5 -C.sub.8 -cycloalkyl whose carbon skeleton may be interrupted by one or more of --O--, --S-- and/or --NR.sup.1 --;aryl or hetaryl, which may each be monosubstituted or poly-substituted by C.sub.1 -C.sub.18 -alkyl, C.sub.1 -C.sub.6 -alkoxy, cyano, --CONHR.sup.2, --NHCOR.sup.2 and/or aryl- or hetaryl-azo, which may each be substituted by C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.6 -alkoxy or cyano, whereR.sup.2 is hydrogen; C.sub.1 -C.sub.18 -alkyl; aryl or hetaryl, which may each be substituted by C.sub.1 -C.sub.6 -alkyl, C.sub.Type: GrantFiled: June 18, 1999Date of Patent: September 26, 2000Assignees: BASF Aktiengesellschaft, Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V. BerlinInventors: Klaus Muellen, Heribert Quante, Arno Bohm
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Patent number: 6013777Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.Type: GrantFiled: June 10, 1998Date of Patent: January 11, 2000Assignee: Ciba Specialty Chemicals CorporationInventors: Zhimin Hao, John S. Zambounis, Abul Iqbal
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Patent number: 5981773Abstract: A process for forming perylene-3, 4-dicarboxylic anhydrides by reacting a corresponding perylene-3,4:9, 10-tetracarboxylic dianhydride with a sterically hindered amine, as a base, at an elevated temperature.Type: GrantFiled: January 14, 1998Date of Patent: November 9, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Heinz Langhals, Petra Christa Von Unold, Markus Speckbacher
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Patent number: 5886160Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.Type: GrantFiled: June 12, 1998Date of Patent: March 23, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Zhimin Hao, John S. Zambounis, Abul Iqbal
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Patent number: 5874580Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2,3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m und n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.Type: GrantFiled: June 2, 1998Date of Patent: February 23, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Zhimin Hao, John S. Zambounis, Abul Iqbal
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Patent number: 5861411Abstract: A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.Type: GrantFiled: April 10, 1996Date of Patent: January 19, 1999Assignee: Mitsubishi Chemical CorporationInventors: Kunihiro Ninomiya, deceased, Ken-ichi Saito, Mamoru Sugano, Akihiro Tobe, Yasuhiro Morinaka, Tomoko Bessho, Haruko Harada
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Patent number: 5679671Abstract: The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibition activity.This amino acid derivative is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or an acyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an ary group which may have a substituent, a heteroaryl group which may have a substituent, an arylalkyl group which may have a substituent or a heteroarylalkyl group which may have a substituent;m and n represent each independently an integer of 0, 1 or 2 andJ represents a cyclic group having an angiotensin I-converting enzyme inhibition activity.Type: GrantFiled: January 25, 1995Date of Patent: October 21, 1997Assignee: Eisai Co., Ltd.Inventors: Hitoshi Oinuma, Shinji Suda, Naoki Yoneda, Makoto Kotake, Kenji Hayashi, Kazutoshi Miyake, Nobuyuki Mori, Mamoru Saito, Toshiyuki Matsuoka, Masayuki Namiki, Takeshi Sudo, Shigeru Souda
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Patent number: 5650513Abstract: Reacting the industrially readily available perylene-3,4,9,10-tetracarboxylic dianhydride (3) with specific primary amines in the presence of water gives perylene-3,4-dicarboxylic bisimides (2). Their hydrolysis affords the perylene-3,4-dicarboxylic anhydride on a preparative scale, and this anhydride is reacted with any primary amines to give likewise the corresponding imides 2. Condensation of the anhydride with diamines results in novel types of dyes, namely perylene-3,4-dicarboxamidines which have very good fastness properties. Also claimed are specific perylene-3,4-dicarboxylic diesters, perylene-3,4-dicarboxylic ester amides, perylene-3,4-dicarboxamidines and perylene-3,4-dicarbonyl derivatives, processes for preparing these compounds and their use.Type: GrantFiled: November 10, 1994Date of Patent: July 22, 1997Assignee: Ciba-Geigy CorporationInventors: Heinz Langhals, Leonhard Feiler
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Patent number: 5561232Abstract: Compounds of formulaA(B).sub.x, (I),whereinx is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1. These carbamate group-containing soluble chromophores am distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.Type: GrantFiled: October 6, 1994Date of Patent: October 1, 1996Assignee: Ciba-Geigy CorporationInventors: Zhimin Hao, John S. Zambounis, Abul Iqbal
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Patent number: 5536728Abstract: A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.Type: GrantFiled: December 8, 1994Date of Patent: July 16, 1996Assignee: Mitsubishi Chemical CorporationInventors: Kunihiro Ninomiya, deceased, Ken-ichi Saito, Mamoru Sugano, Akihiro Tobe, Yasuhiro Morinaka, Tomoko Bessho, Haruko Harada
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Patent number: 5397785Abstract: A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.Type: GrantFiled: September 2, 1993Date of Patent: March 14, 1995Assignee: Mitsubishi Kasei CorporationInventors: Kunihiro Ninomiya, deceased, Ken-ichi Sato, Mamoru Sugano, Akihiro Tobe, Yasuhiro Morinaka, Tomoko Bessho, Haruko Harada
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Patent number: 5302589Abstract: The present invention relates to certain substituted 17 .beta.-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 arei) independently hydrogen or lower alkyl and the bond between the carbons bearing R.sup.1 and R.sup.2 is a single or a double bond, orii) taken together are a --CH.sub.2 -- group to form a cyclopropane ring, and the bond between the carbons bearing R.sup.1 and R.sup.2 is a single bond;X is ##STR2## wherein R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently hydrogen or lower alkyl,p and q are independently either 0 or 1;R.sup.3 is lower alkyl, lower alkenyl, lower cycloalkyl, lower alkoxy, thiopyridyl, adamantyl, --NR.sup.9 R.sup.10 or --Ar--NR.sup.9 R.sup.10whereinR.sup.9 and R.sup.Type: GrantFiled: August 7, 1992Date of Patent: April 12, 1994Assignee: Glaxo, Inc.Inventors: Stephen V. Frye, David Middlemiss, Francis G. Fang
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Patent number: 5232915Abstract: 9.alpha.-Hydroxy-19,11.beta.-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R.sup.1, R.sup.2, G, Z, R.sup.4 --Y and R.sup.4' --Y' follows from the description. The steroids of general formula I have antigestagen and/or antiglucocorticoidal action and can be used for the production of pharmaceutical agents.Type: GrantFiled: January 14, 1992Date of Patent: August 3, 1993Assignee: Schering AktiengesellschaftInventors: Eckhard Ottow, Gunter Neef, Rudolf Wiechert, Walter Elger, Sybille Beier, Karl-Heinrich Fritzemeier
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Patent number: 4739063Abstract: Selective hydrogenation of the unsaturated nitrogen-containing ring in heterocyclic aromatic compounds is promoted by the use of hydrogenation catalysts selected from the group consisting of iridium, iridium dioxide, rhenium, molybdenum oxide, tungsten oxide, chromium trioxide, ferric oxide, iron pentacarbonyl, cobalt oxide-molybdenum oxide and copper chromite.Type: GrantFiled: December 4, 1985Date of Patent: April 19, 1988Assignee: Phillips Petroleum CompanyInventor: James E. Shaw
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Patent number: 4739064Abstract: Selective hydrogenation of the unsaturated nitrogen-containing ring in heterocyclic aromatic compounds is promoted by the use of at least one hydrogenation catalyst selected from the group consisting of nickel, cobalt, palladium, platinum, ruthenium and rhodium in the presence of reaction modifiers exemplified by carbon monoxide, carbon disulfide and hydrogen sulfide.Type: GrantFiled: December 4, 1985Date of Patent: April 19, 1988Assignee: Phillips Petroleum CompanyInventor: James E. Shaw