Having -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Six-membered Hetero Ring (e.g., Lysergic Acid, Etc.) Patents (Class 546/69)
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Patent number: 5441961Abstract: The present invention provides (8.beta.)-N-substituted cyclo or bicycloalkyl-6-(substituted)-ergoline-8-carboxamides useful for occupying 5HT.sub.2 or 5HT.sub.1c receptors in mammals. The invention also provides methods for treating a variety of disorders and conditions related to or affecting these receptors as well as pharmaceutical formulations of the compounds of the invention.Type: GrantFiled: August 27, 1992Date of Patent: August 15, 1995Assignee: Eli Lilly and CompanyInventors: Marlene L. Cohen, David W. Robertson
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Patent number: 5430031Abstract: The present invention provides compounds of the formula (I) ##STR1## wherein A, R.sub.1, R.sub.2 and R.sub.3 are defined as in the specification, or a pharmaceutically acceptable salt thereof. A process for their preparation and the pharmacetical compositions comprising them are also provided.Type: GrantFiled: December 20, 1993Date of Patent: July 4, 1995Assignee: Farmitalia Carlo Erba S.r.l.Inventors: Sergio Mantegani, Enzo Brambilla, Carla Caccia, Nicola Carfagna
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Patent number: 5382669Abstract: The invention provides a process for the preparation of ergoline derivatives of the formula I ##STR1## the process comprising reacting an ergoline amide of the formula II with an isocyanate of formula III ##STR2## in presence of a metal catalyst and of a phosphorus compound. The compounds of the formula I are useful antiprolactinic and antiparkinson agents.Type: GrantFiled: March 9, 1993Date of Patent: January 17, 1995Assignee: Farmitalia Carlo Erba S.r.l.Inventors: Ilaria Candiani, Walter Cabri, Angelo Bedeschi, Franco Zarini
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Patent number: 5288724Abstract: There are disclosed novel ergoline derivatives of 2-propinylamine of the general formula I ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 independently represent a hydrogen atom or a straight-chain or branched-chain C.sub.1 -C.sub.6 alkyl group,X represents a hydrogen or a halogen atom,Z represents a carbonyl or methylene group andC.sub.9 C.sub.10 represents a single or a double bond, diastereomeric forms, racemates and acid addition salts thereof.There are also described a process for the manufacture of the compounds of the general formula I and a pharmaceutical composition containing the same.The compounds of the general formula I can be used in the pharmaceutical industry as active substances for the manufacture of medicaments used in the treatment of hypertension, migraine, anxiety states, depressions, obesity etc.Type: GrantFiled: June 22, 1992Date of Patent: February 22, 1994Assignee: LEK, tovarna farmacevtskihInventors: Rudolf Rucman, Breda Bole-Vunduk, Magdalena Ocvirk, Bogomila Lavric, Igor Krisch
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Patent number: 5274184Abstract: The present invention relates to compounds of the general formula I ##STR1## wherein A.sup..sym. and B.sup..sym. independently of one another denote a proton, with the limitation that they do not both simultaneously denote protons, the equivalent part of the barium ion, an ion of the general formula II ##STR2## or an ion of the general formula III ##STR3## and wherein R.sup.1 to R.sup.8, R.sup.11 to R.sup.16, X and m and n are as defined in the description, processes for their preparation and their use as charge control agents in toners and developers and as charge improving agents in powders and varnishes.Type: GrantFiled: October 2, 1991Date of Patent: December 28, 1993Assignee: Cassella AktiengesellschaftInventors: Gert Nagl, Hans-Tobias Macholdt
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Patent number: 5219862Abstract: Compounds of formula I ##STR1## in which R.sup.2 means optionally substituted C.sub.1-7 alkyl, C.sub.2-7 alkenyl, CH.sub.2 --O--C.sub.1-4 alkyl or CH.sub.2 --S--C.sub.1-4 alkylR.sup.6 means C.sub.2-6 alkyl, C.sub.3-6 alkenyl or C.sub.3-5 -cycloalkyl-C.sub.1-2 alkyl andR.sup.8 means CH.sub.2 --X, ##STR2## in which X stands for CN, OCH.sub.3, SCH.sub.3 or CONH.sub.2 and R.sup.1 stands for hydrogen, halogen, methyl or methoxy, and R.sup.3 and R.sup.4 each mean C.sub.1-4 alkyl or (CH.sub.2).sub.n --N(CH.sub.3).sub.2, in which n=1-4, and their acid addition salts, the process for their production, their use as pharmaceutical agents as well as intermediate compounds are described.Type: GrantFiled: December 21, 1990Date of Patent: June 15, 1993Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Thomas Brumby, Helmut Wachtel, Jonathan Turner, Peter A. Loschmann
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Patent number: 5141944Abstract: This invention provides N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating sexual dysfunction, hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.Type: GrantFiled: June 24, 1991Date of Patent: August 25, 1992Assignee: Eli Lilly and CompanyInventors: Marlene L. Cohen, David W. Robertson
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Patent number: 5097031Abstract: The invention relates to a novel stereoselective process for the preparation of dihdyrolysergol from lysergol by hydrogenation in the presence of solvent and palladium catalyst applied on a carrier, which comprises hydrogenating lysergol in the presence of one or more aprotic solvent(s) containing tertiary nitrogen atom(s) and a palladium catalyst applied on activated carbon, and recovering the product obtained from the reaction mixture in a known manner.Type: GrantFiled: June 22, 1990Date of Patent: March 17, 1992Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Istvan Polgar, Jozsef Foldesi, Janos Kiss, Piroska Major nee Forstner, Karoly Molnar, Andras Sugar, Tamas Szen, Katalin Balogh nee Nemes
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Patent number: 5043341Abstract: This invention provides N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating sexual dysfunction, hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.Type: GrantFiled: April 11, 1990Date of Patent: August 27, 1991Assignee: Eli Lilly and CompanyInventors: Marlene L. Cohen, David W. Robertson
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Patent number: 4980475Abstract: Processes for the preparation of esters of N.sub.1 -methyl-10.alpha.-methoxylumilysergol are described, in which lysergol esters are subjected to N-methylation and subsequently to photochemical reaction with methanol/H.sub.2 SO.sub.4. The esters of N.sub.1 -methyl-10-methoxylumilysergol obtained in this way can then be saponified or converted directly into other esters.Type: GrantFiled: March 26, 1985Date of Patent: December 25, 1990Assignee: I d B Holding S.P.A.Inventors: Ezio Bombardelli, Giuseppe Mustich
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Patent number: 4970314Abstract: 2-bromo-8-ergolinyl compounds of the formula ##STR1## wherein R.sup.8 is NH.sub.2, NH--CONEt.sub.2, CONH.sub.2, ##STR2## and ##STR3## wherein R.sup.1 =C.sub.1-4 -alkyl andR.sup.2 =C.sub.1-4 -alkyl and benzyl,R.sup.9 and R.sup.10 each mean hydrogen or, together, a bond, and the substituent R.sup.8 can be in the .alpha.- or .beta.- position, and their acid addition salts,can be prepared from corresponding 8-ergolinyl compounds and their acid addition salts by bromination with elemental bromine in the presence of hydrogen bromide in a halogenated hydrocarbon.Type: GrantFiled: November 5, 1984Date of Patent: November 13, 1990Assignee: Schering AktiengesellschaftInventors: Helmut Borner, Gregor Haffer, Gerhard Sauer
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Patent number: 4968801Abstract: Ergoline derivatives of general Formula I ##STR1## wherein C.sub.8 C.sub.9 and C.sub.9 C.sub.10 are both CC-single bonds or one is a C.dbd.C-double bond,R.sup.6 is C.sub.1-4 alkyl,R.sup.8 is methyl, hydroxymethyl, carbonylmethoxy, ureido or N,N-diethylureido, each in the .alpha.- or .beta.-position, andR is hydrogen or nitro,are prepared by dehydrogenation of corresponding 2,3-dihydroergoline derivatives using an electrophilic reagent in an apolar solvent and a base.Type: GrantFiled: May 25, 1989Date of Patent: November 6, 1990Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Helmut Biere, Gregor Haffer, Andreas Huth
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Patent number: 4968802Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.Type: GrantFiled: January 10, 1990Date of Patent: November 6, 1990Assignee: Eli Lilly and CompanyInventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
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Patent number: 4939258Abstract: Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.Type: GrantFiled: January 10, 1990Date of Patent: July 3, 1990Assignee: Eli Lilly and CompanyInventors: Kathleen R. Whitten, William L. Garbrecht, Gifford P. Marzoni, C. John Parli
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Patent number: 4931447Abstract: This invention provides (8.beta.)-N-cycloalkyl-1-alkyl-6-(substituted) ergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.Type: GrantFiled: August 14, 1989Date of Patent: June 5, 1990Assignee: Eli Lilly and CompanyInventors: Mark M. Foreman, William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
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Patent number: 4914100Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.Type: GrantFiled: April 24, 1989Date of Patent: April 3, 1990Assignee: Eli Lilly and CompanyInventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
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Patent number: 4908449Abstract: A process for preparing 1-methyllysergol or 10.alpha.-methoxy-1-methyllumilysergol, which comprises adding a base, which is an alkali metal hydride or alcoholate, to a solution of lyergol or 10.alpha.-methoxylumilysergol in a polar aprotic solvent in such a way that the molecular ratio between the base and the lysergol or 10.alpha.-methoxylumilysergol remains less than 0.5:1, and then adding a methylating agent which is methyl iodide, methyl sulphate or trimethylsulphonium iodide.1-methyllysergol and 10.alpha.-methoxy-1-methyllysergol are useful intermediates in the synthesis of pharmacological compounds.Type: GrantFiled: March 27, 1989Date of Patent: March 13, 1990Assignee: Rhone-Poulenc SanteInventor: Christian Gervais
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Patent number: 4906639Abstract: Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.Type: GrantFiled: April 11, 1989Date of Patent: March 6, 1990Assignee: Eli Lilly and CompanyInventors: Kathleen R. Whitten, William L. Garbrecht, Gifford P. Marzoni, C. John Parli
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Patent number: 4902691Abstract: This invention provides (8.beta.)-N-heteroalkyl-1-alkyl-6-(substituted)ergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating sexual dysfunction, hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.Type: GrantFiled: December 19, 1988Date of Patent: February 20, 1990Assignee: Eli Lilly and CompanyInventors: Marlene L. Cohen, David W. Robertson
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Patent number: 4897382Abstract: Organic amide compounds of the formula ##STR1## wherein R.sub.1 --CO is a residue of a carboxylic acid with the proviso that the carboxylic acid is not a natural fatty acid normally bound to nitrogen of nitrogenous lipids, R.sub.2 is a hydrogen atom, a C.sub.1-7 alkyl group, or a C.sub.4-7 cycloalkyl group, and R.sub.3-N is a residue of a nitrogenous lipid. The compounds are useful in increasing or stimulating the in vivo biological activity of in vitro biologically active carboxylic acids.Type: GrantFiled: June 21, 1988Date of Patent: January 30, 1990Assignee: Fidia S.p.A.Inventors: Francesco della Valle, Aurelio Romeo
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Patent number: 4847261Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.Type: GrantFiled: September 29, 1988Date of Patent: July 11, 1989Assignee: Eli Lilly and CompanyInventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
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Patent number: 4845224Abstract: Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.Type: GrantFiled: April 29, 1987Date of Patent: July 4, 1989Assignee: Eli Lilly and CompanyInventors: Kathleen R. Whitten, William L. Garbrecht, Gifford P. Marzoni, C. John Parli
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Patent number: 4835159Abstract: The present invention provides novel bicyclic ergoline esters useful as serotonin antagonists.Type: GrantFiled: August 24, 1988Date of Patent: May 30, 1989Assignee: Eli Lilly and CompanyInventors: William L. Garbrecht, Gifford P. Marzoni, Pawel Fludzinski
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Patent number: 4820713Abstract: Ketoalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.Type: GrantFiled: May 23, 1988Date of Patent: April 11, 1989Assignee: Eli Lilly and CompanyInventors: Gifford P. Marzoni, William L. Garbrecht
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Patent number: 4816587Abstract: The invention relates to a novel process for the halogenation in 2-position of ergot alkaloids. The process is characterized by that as a halogenating agent a system consisting of dimethylsulfoxide, a trialkylhalosilane or triarylhalosilane and optionally a hydrogen halide is used.Type: GrantFiled: June 5, 1987Date of Patent: March 28, 1989Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Gabor Megyeri, Tibor Keve, Lajos Kovacs, Jr., Bela Stefko, Erik Bogsch, Anna Kassia nee Zieger, Ferenc Trischler, Gabor Szepesi, Maria Gazdag
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Patent number: 4810710Abstract: Method of blocking 5HT without effect on alpha receptors with 1-loweralkyl-6-straight chain alkyl-8.beta.-hydroxycycloalkyloxycarbonylergolines.Type: GrantFiled: July 25, 1988Date of Patent: March 7, 1989Assignee: Eli Lilly and CompanyInventors: Marlene L. Cohen, Ray W. Fuller, William L. Garbrecht, Kathleen R. Whitten
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Patent number: 4798834Abstract: A therapeutic method employing 2,3-dihydroergolines is disclosed. Said method enhances serotonergic function in the nervous system of a mammal in need thereof, thereby finding application in serotonin-mediated physiological manifestations including memory, depression, anxiety, pain and appetite. Also disclosed are pharmaceutical compositions containing said 2,3-dihydroergolines in admixture with pharmaceutically acceptable diluents and carriers.Type: GrantFiled: August 31, 1987Date of Patent: January 17, 1989Assignee: Eli Lilly and CompanyInventors: Leander Merritt, John S. Ward
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Patent number: 4782063Abstract: The present invention provides novel bicyclic ergoline esters useful as serotonin antagonists.Type: GrantFiled: May 11, 1987Date of Patent: November 1, 1988Assignee: Eli Lilly and CompanyInventors: William L. Garbrecht, Gifford P. Marzoni, Pawel Fludzinski
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Patent number: 4772709Abstract: Ketoalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful and 5HT receptor antagonists.Type: GrantFiled: October 1, 1985Date of Patent: September 20, 1988Assignee: Eli Lilly and CompanyInventors: Gifford P. Marzoni, William L. Garbrecht
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Patent number: 4757053Abstract: Organic amide compounds of the formula ##STR1## wherein R.sub.1 --CO is a residue of a carboxylic acid with the proviso that the carboxylic acid is not a natural fatty acid normally bound to nitrogen of nitrogenous lipids, R.sub.2 is a hydrogen atom, a C.sub.1-7 alkyl group, or a C.sub.4-7 cycloalkyl group, and R.sub.3-N is a residue of a nitrogenous lipid. The compounds are useful in increasing or stimulating the in vivo biological activity of in vitro biologically active carboxylic acids.Type: GrantFiled: December 11, 1985Date of Patent: July 12, 1988Assignee: Fidia, S.p.A.Inventors: Francesco della Valle, Aurelio Romeo
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Patent number: 4754037Abstract: A process for preparing an N-methyl derivative of ergoline of formula: ##STR1## in which R.sub.1 denotes a carboxy or alkoxycarbonyl group in which the alkyl portion contains 1 to 4 carbon atoms, R.sub.2 denotes a hydrogen atom or a methoxy group and R.sub.3 denotes a hydrogen atom or R.sub.2 and R.sub.3 together form a direct bond, or in which R.sub.1 denotes a hydroxymethyl group, R.sub.2 denotes a hydrogen atom or a methoxy group and R.sub.3 denotes a hydrogen atom, which comprises methylating an ergoline derivative of formula: ##STR2## in which R.sub.1, R.sub.2 and R.sub.3 are defined as above, with methyl carbonate in the presence of a basic agent, in an apolar aprotic solvent in the present of a phase transfer catalyst.Type: GrantFiled: July 10, 1986Date of Patent: June 28, 1988Assignee: Rhone-Poulenc SanteInventor: Christian Gervais
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Patent number: 4748248Abstract: A process for preparing an ergoline of the formula ##STR1## wherein C.sub.9 ----C.sub.10 is a CC single or double bond,R.sup.1 is hydrogen or CONR.sub.2, R being hydrogen, methyl, or ethyl, and wherein NR' is in the .alpha.- or .beta.- position,R.sup.2 is lower alkyl of up to 3 carbon atoms, and the salts thereof,comprises treating the corresponding ergolinyl carboxylic acid amide with lead(IV) acetate in an aprotic polar solvent; reacting the intermediarily formed corresponding isocyanate with water or with a reactive amine of up to 4 carbon atoms, (e.g. a mono- or dialkylamine of up to 4-C atoms); and, optionally, treating the resultant product with an acid to form the corresponding salt.Type: GrantFiled: December 13, 1985Date of Patent: May 31, 1988Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Gregor Haffer
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Patent number: 4739061Abstract: A process for preparing an N-methyl derivative of methyl dihydrolysergate and methyl methoxylumilysergate, of formula: ##STR1## in which R.sub.1 denotes a hydrogen atom or a methoxy group, which comprises reacting a methylating agent with a compound of formula: ##STR2## in which R.sub.1 is defined as above, in the presence of a quaternary salt, in the presence of a solid metal alcoholate of formula CH.sub.3 --OM in which M denotes an alkali metal atom, or an alkali metal hydride, and in the presence of a dehydrating agent of formula R.sub.2 --COO--CH.sub.3 in which R.sub.2 denotes a hydrogen atom or an alkyl, alkyloxy, alkyloxycarbonyl or aryl group or of formula R.sub.3 --C(OCH.sub.3).sub.3 in which R.sub.3 denotes a hydrogen atom, an alkyl group or an aryl group.Type: GrantFiled: July 10, 1986Date of Patent: April 19, 1988Assignee: Rhone-Poulenc SanteInventor: Christian Gervais
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Patent number: 4734501Abstract: The present invention provides a process for N-alkylating dihydrolysergic acid with a substituted benzenesulfonate derivative.Type: GrantFiled: October 1, 1985Date of Patent: March 29, 1988Assignee: Eli Lilly and CompanyInventor: Gifford P. Marzoni
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Patent number: 4731367Abstract: Novel ergoline derivatives, substituted in the 2-position, of the formula ##STR1## wherein C.sub.8 -C.sub.9 and C.sub.9 -C.sub.10 each independently is a CC-single or a C.dbd.C-double bond, but not together a cumulated double bond, and the substituent in the 8-position is in the .alpha.- or .beta.-configuration where C.sub.8 -C.sub.9 is a CC-single bond,R.sup.2 isCN, SR, SOR, ##STR2## wherein n is 2 or 3, ##STR3## and --CH(OH)R, wherein R has the meaning of H or C.sub.1-4 -alkyl, the grouping COR' and CSR' wherein R'.dbd.OH, OC.sub.1-4 -alkyl, benzyl, NH.sub.2 or NHR",the grouping CH.dbd.CH--CO.sub.2 R" and CH.sub.2 --CH.sub.2 --CO.sub.2 R" wherein R".dbd.C.sub.1-4 -alkyl,the grouping C.vertline.C-R'" and HC.dbd.CH--R'" wherein R'".dbd. hydrogen, C.sub.1-4 -alkyl, phenyl, CH.sub.2 OH, CR".sub.2 OH, ##STR4## CO.sub.2 R", CH.sub.2 NR".sub.2 or SiMe.sub.2 R"; C.sub.1-3 -alkyl, or C.sub.1-3 -alkyl substituted by OH or phenyl; or ##STR5## wherein R" is C.sub.1-4 alkyl, R.sup.6 is C.sub.1-4 -alkyl andR.sup.Type: GrantFiled: April 9, 1985Date of Patent: March 15, 1988Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Andreas Huth, Helmut Wachtel, Herbert H. Schneider
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Patent number: 4714704Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.Type: GrantFiled: October 1, 1985Date of Patent: December 22, 1987Assignee: Eli Lilly and CompanyInventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
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Patent number: 4713385Abstract: Alkoxy or dialkoxyalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.Type: GrantFiled: October 1, 1985Date of Patent: December 15, 1987Assignee: Eli Lilly and CompanyInventors: Gifford P. Marzoni, William L. Garbrecht
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Patent number: 4713384Abstract: Method of blocking 5HT without effect on alpha receptors with 1-loweralkyl-6-straight chain alkyl-8.beta.-hydroxycycloalkyloxycarbonylergolines.Type: GrantFiled: October 1, 1985Date of Patent: December 15, 1987Assignee: Eli Lilly and CompanyInventors: Marlene L. Cohen, Ray W. Fuller, William L. Garbrecht, Kathleen R. Whitten
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Patent number: 4704395Abstract: Cyclic ether esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.Type: GrantFiled: December 20, 1985Date of Patent: November 3, 1987Assignee: Eli Lilly and CompanyInventors: Gifford P. Marzoni, William L. Garbrecht
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Patent number: 4704396Abstract: Phenacyl or substituted phenacyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.Type: GrantFiled: December 20, 1985Date of Patent: November 3, 1987Assignee: Eli Lilly and CompanyInventors: Kathleen R. Whitten, William L. Garbrecht
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Patent number: 4697017Abstract: The invention relates to a novel process for the preparation of 2-bromo-.alpha.-ergocryptine and its acid addition salt by brominating .alpha.-ergocryptine in such a way that the bromination is carried out at room temperature by using a dimethylsulphoxide-hydrogen bromide mixture containing no more 0.02% of water and, if desired, converting the thus-obtained 2-bromo-.alpha.-ergocryptine to an acid addition salt in a known manner.Type: GrantFiled: May 30, 1986Date of Patent: September 29, 1987Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Gabor Megyeri, Tibor Keve, Janos Galambos, Lajos Kovacs, Jr., Bela Stefko, Erik Bogsch, Ferenc Trischler
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Patent number: 4695635Abstract: 2-bromoergolines can be reduced in good yields, without dimerization as determined by NMR product analysis, to the corresponding 2,3-dihydroergolines under otherwise conventional reducing conditions by introducing 2-bromoergolines, together with sodium borohydride, into trifluoroacetic acid under cooling to prevent the reaction mixture from rising above ambient temperature.Type: GrantFiled: March 28, 1985Date of Patent: September 22, 1987Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Gregor Haffer
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Patent number: 4690929Abstract: Compounds of formula I: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group; R.sub.2 represents a hydrogen or halogen atom or a methyl, cyano, C.sub.1 -C.sub.4 alkylthio or phenylthio group; R.sub.7 and R.sub.8 represent hydrogen atoms and R.sub.3 represents a hydrogen atom or a methoxy group, or R.sub.7 represents a hydrogen atom and R.sub.3 and R.sub.8 taken together represent a bond, or R.sub.3 represents a hydrogen atom or a methoxy group and R.sub.7 and R.sub.8 taken together represent a bond; R.sub.4 represents a hydrocarbon group having from 1 to 4 carbon atoms; R.sub.5 represents a hydrogen atom or a hydrocarbon group having from 1 to 4 carbon atoms or a phenyl group; X represents an oxygen or sulphur atom or an imino group, R.sub.9 represents a hydrogen atom and B represents a cyano, a C.sub.2 -C.sub.5 alkoxycarbonyl or carbamoyl group, or R.sub.Type: GrantFiled: April 26, 1984Date of Patent: September 1, 1987Assignee: Farmitalia Carlo ErbaInventors: Luigi Bernardi, Laura Chiodini, Sergio Mantegani, Daniela Ruggieri, Aldemio Temperilli, Patricia Salvati
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Patent number: 4684728Abstract: A biologically active compound can be solubilized by reaction in different sequences to form a derivative carrying the active moiety, a linking group such as an optionally substituted diisocyanate radical, a polyether moiety such as a polyoxyethylene radical, and a terminal group such as a butyl radical, e.g. ##STR1## n=1 to 400. The active materials can be agricultural chemicals, pharmaceuticals, and the like.Type: GrantFiled: December 28, 1979Date of Patent: August 4, 1987Assignee: Bayer AktiengesellschaftInventors: Edgar Mohring, Hanns P. Muller, Peter Roessler, Kuno Wagner, Helmut Tietz
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Patent number: 4683237Abstract: Mono, difluoro or trifluoroalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acid, useful as 5HT.sub.2 receptor antagonists.Type: GrantFiled: December 20, 1985Date of Patent: July 28, 1987Assignee: Eli Lilly and CompanyInventors: Gifford P. Marzoni, William L. Garbrecht
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Patent number: 4683236Abstract: Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT.sub.2 receptor antagonists.Type: GrantFiled: October 1, 1985Date of Patent: July 28, 1987Assignee: Eli Lilly and CompanyInventors: Kathleen R. Whitten, William L. Garbrecht, Gifford P. Marzoni, C. John Parli
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Patent number: 4681880Abstract: 9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.Type: GrantFiled: July 2, 1985Date of Patent: July 21, 1987Assignee: Sandoz Ltd.Inventors: Hans Kobel, Jean-Jacques Sanglier, Hans Tscherter, Georg Bolliger
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Patent number: 4675404Abstract: Ergoline derivatives of formula: ##STR1## wherein n=0,1,2; R.sub.1 =H, CH.sub.3 ; R.sub.2 =H, CH.sub.3, halogen; R.sub.3 =H, OCH.sub.3 ; R.sub.4 =hydrocarbon group and R.sub.5 is a residue of general formula II, III, IV, V, VI, VII: ##STR2## wherein R.sub.6 =H, Cl, OCH.sub.3, NR.sub.11 R.sub.12, wherein R.sub.11 and R.sub.12 =H, lower alkyl; phenyl or are bonded together to form a heterocyclic ring, R.sub.7, R.sub.8 and R.sub.9 and R.sub.10 =H or C.sub.1 -C.sub.3 alkyl, with the proviso that if R.sub.5 is of formula II and R.sub.2 =R.sub.7 =R.sub.8 =H, then R.sub.4 is not methyl or n is not 0.Pharmaceutically acceptable acid addition salts are also provided. A method for their preparation is also provided.The compounds have anti-depressive, anti-hypertensive and antiprolactin activity.Type: GrantFiled: July 14, 1986Date of Patent: June 23, 1987Assignee: Farmitala Carlo Erba S.p.A.Inventors: Luigi Bernardi, Aldemio Temperilli, Germano Bosisio, Gabriella Traquandi, Rosanna Eccel, Alessandro Rossi, Patricia Salvati
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Patent number: 4632990Abstract: There are provided ergoline derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, R.sub.2 represents a hydrogen or halogen atom or a methyl group, R.sub.3 represents a hydrogen atom or a methoxy group, R.sub.4 represents a hydrocarbon group having from 1 to 4 carbon atoms; each of X and W independently represents a hydrogen atom, a methyl group, a chlorine atom or a methoxy group, and n is 0, 1 or 2. A method for their preparation is also provided. The compounds have strong antiprolactin activity.Type: GrantFiled: April 13, 1983Date of Patent: December 30, 1986Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Luigi Bernardi, Enzo Brambilla, Laura Chiodini, Enrico di Salle, Daniela Ruggieri, Osvaldo Sapini, Aldemio Temperilli
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Patent number: 4609731Abstract: The present invention provides an improved process for the production of a compound of formula I ##STR1## wherein R.sub.1 is carboxyl, alkoxy(C.sub.1-5)carbonyl, amido, alkyl(C.sub.1-5)amido, di(alkyl(C.sub.1-5)amido or an amido radical of formula II ##STR2## wherein R.sub.a is alkyl(C.sub.1-4),R.sub.b is alkyl(C.sub.1-4) or benzyl, andR.sub.2 is hydrogen or alkyl(C.sub.1-4), andeitherR.sub.3 is hydrogen and R.sub.4 is hydrogen or alkoxy(C.sub.1-4)orR.sub.3 and R.sub.4 together are a single bond,characterized in that a compound of formula III ##STR3## wherein R.sub.1 to R.sub.4 are as defined above,is brominated with a bromine complex of 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine.Type: GrantFiled: April 18, 1980Date of Patent: September 2, 1986Assignee: Sandoz Ltd.Inventors: Milan Jurgec, Rudolf Rucman, Branko Stanovnik, Miha Tisler