Phenanthrolines (including Hydrogenated) Patents (Class 546/88)
  • Patent number: 9074266
    Abstract: The invention relates to novel compounds useful as ligands of actinides and which meet general formula (I) hereinafter: where: R1 and R2=H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; R3, R4, R5 and R6=H; a C1 to C12 hydrocarbon group; a monocyclic aryl or aryl-(C1 to C6)alkyl group; a —NR7R8 or —NR7COR8 group where R7=H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group, while R8=a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; an —OR9 or —SR9 group where R9=a C1 to C12 hydrocarbon group, a monocyclic C6 aryl or aryl-(C1 to C6)alkyl group. A further subject of the invention is a method for synthesizing these compounds and the uses thereof.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: July 7, 2015
    Assignees: Commissariat à l'énergie atomique et aux énergies alternatives, UNIVERSITE DE NANTES
    Inventors: Julia Bisson, Marie-Christine Charbonnel, Nathalie Boubals, Manuel Miguirditchian, Denis Guillaneux, Dominique Guillaumont, Cecile Marie, Didier Dubreuil, Muriel Pipelier, Virginie Blot
  • Publication number: 20150131302
    Abstract: A novel organic compound is provided. Alternatively, an organic compound that can be used as an electron-transport material of a light-emitting element is provided. An organic compound in which heteroaromatic groups each including two pyridine rings are bonded to the 2- and 8-positions of dibenzofuran is provided. The organic compound is an organic compound that can be used as an electron-transport material of a light-emitting element.
    Type: Application
    Filed: November 10, 2014
    Publication date: May 14, 2015
    Inventors: Hideko Inoue, Yui Yamada, Tsunenori Suzuki, Satoshi Seo
  • Publication number: 20150125550
    Abstract: A method of inhibiting cancer cell growth is provided. In some versions, the method includes exposing lung cancer cells or glioma cells to 2,9-di-sec-butyl-1,10-phenanthroline (SBP) or derivatives of SBP in an amount effective to inhibit glioma cell growth. Also, a method of treating a lung cancer or a glioma tumor in a subject in need of such treatment is provided. The method includes administering SBP or derivatives of SBP to the subject in an amount effective to treat the lung cancer or glioma tumor. For either method, the method can further include exposing or administering pseudo five coordinate gold(III) complexes of SBP derivatives.
    Type: Application
    Filed: August 29, 2014
    Publication date: May 7, 2015
    Inventors: Jack F. Eichler, Clement N. David, Emma H. Wilson
  • Publication number: 20150041773
    Abstract: An anthracene-based compound is represented by Formula 1 as below: wherein Ar, R1 to R3, R11 to R13, L1, L2, a1 to a3, b1, b2, n1, n2, m1, m2, o1 and o2 are as defined in the specification. An organic light-emitting device includes the anthracene-based compound.
    Type: Application
    Filed: May 21, 2014
    Publication date: February 12, 2015
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Jun-Ha PARK, Seok-Hwan HWANG, Young-Kook KIM, Hye-Jin JUNG, Eun-Young LEE, Jong-Woo KIM, Jin-O LIM, Sang-Hyun HAN, Kwang-Hyun KIM, Eun-Jae JEONG, Soo-Yon KIM
  • Publication number: 20150018543
    Abstract: The present invention relates to 4H-pyrido[1,2-a]pyrimidin-4-one compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.
    Type: Application
    Filed: April 28, 2014
    Publication date: January 15, 2015
    Applicants: Institut Pasteur Korea, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Priscille BRODIN, Thierry CHRISTOPHE, Zaesung NO, Jaeseung KIM, Auguste GENOVESIO, Denis Philippe Cedric FENISTEIN, Heekyoung JEON, Fanny Anne EWANN, Sunhee KANG, Saeyeon LEE, Min Jung SEO, Eunjung PARK, Monica CONTRERAS DOMINGUEZ, Ji Youn NAM, Eun Hye KIM
  • Publication number: 20140364443
    Abstract: Disclosed are 1,4-dihydro-naphthyridine derivatives and pharmaceutical composition and uses thereof. The 1,4-dihydro-naphthyridine derivatives are a compound capable of inhibiting acetylcholinesterase activity and preventing extracellular calcium from flowing into a cell via a calcium channel, i.e., having a dual-activity, which are of potential importance as a pharmaceutical and can be used to prepare the drugs for treating cardiovascular diseases, cerebrovascular diseases and dementia.
    Type: Application
    Filed: December 7, 2012
    Publication date: December 11, 2014
    Applicant: Jiangsu Simovay Pharmaceutical Co., Ltd.
    Inventors: Rong Chen, Lin Feng, Zhengping Zhang, Fang Fang, Qingli Dong, Fulong Li, Lei Wang, Yao Hua, Shibao Yang, Peng Wang
  • Publication number: 20140319473
    Abstract: A compound represented by Formula 1 below and an organic light-emitting device including the compound are provided: Substituents in Formula 1 are the same as defined in the specification.
    Type: Application
    Filed: September 13, 2013
    Publication date: October 30, 2014
    Applicant: Samsung Display Co., Ltd.
    Inventor: Jung-Sub Lee
  • Publication number: 20140286927
    Abstract: A engineered composition and method of delivery of said composition providing effective therapy for the treatment of ulcerative colitis, and Crohn's disease.
    Type: Application
    Filed: June 19, 2012
    Publication date: September 25, 2014
    Inventor: Peter Edward Smith
  • Publication number: 20140225968
    Abstract: The present invention provides a novel organic compound having a high quantum yield and a high color purity. Provided is an organic compound represented by Formula (1) described in Claim 1. In Formula (1), R1 to R20 are each independently selected from hydrogen atoms, halogen atoms, substituted or unsubstituted alkyl groups, substituted or unsubstituted alkoxy groups, substituted or unsubstituted amino groups, substituted or unsubstituted aryl groups, substituted or unsubstituted heterocyclic groups, substituted or unsubstituted aryloxy groups, substituted or unsubstituted thiol groups, silyl groups, and cyano groups.
    Type: Application
    Filed: September 5, 2012
    Publication date: August 14, 2014
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Jun Kamatani, Naoki Yamada, Akihito Saitoh
  • Publication number: 20140217393
    Abstract: An organic electroluminescence device including an anode and a cathode being opposed, wherein a first organic thin film layer and a second organic thin film layer are provided between the anode and the cathode sequentially from the anode side; the first organic thin film layer including an aromatic heterocyclic derivative A represented by the following formula (1-1) and a phosphorescent emitting material; and the second organic thin film layer including an aromatic heterocyclic derivative B represented by the following formula (2-1):
    Type: Application
    Filed: September 6, 2012
    Publication date: August 7, 2014
    Inventors: Tomoki Kato, Nobuhiro Yabunouchi, Takayasu Sado
  • Publication number: 20140221655
    Abstract: The invention provides methods for substituting polyaromatic hydrocarbons or polyheterocyclic compounds with perfluoroalkyl groups. The methods can include heating a polyaromatic hydrocarbon substrate or a polyheterocyclic compound substrate in the presence of a perfluoroalkyl iodide, typically in a closed system, wherein the heating is sufficient to bring both the polyaromatic hydrocarbons or polyheterocyclic compound, and the perfluoroalkyl iodide, into the gas phase, thereby allowing the substrate to react with the perfluoroalkyl iodide in the gas phase to form polyaromatic hydrocarbons or polyheterocyclic compounds having one or more perfluoroalkyl substituents. The methods allow for the creation of versatile libraries of novel perfluoroalkyl-containing derivatives that can serve as important building blocks and active components in biomedical, electronic, and materials applications.
    Type: Application
    Filed: February 6, 2014
    Publication date: August 7, 2014
    Applicant: Colorado State University Research Foundation
    Inventors: Steven S. Strauss, Olga V. Boltalina, Igor V. Kuvychko
  • Patent number: 8795848
    Abstract: Disclosed is an organic electroluminescent device (organic EL device) that is improved in the luminous efficiency, fully secured of the driving stability, and of a simple structure and also disclosed is a compound for organic EL device useful for the said device. The compound for organic EL device is, for example, an indolocarbazole derivative represented by the following general formula (3). The organic EL device comprises a light-emitting layer disposed between an anode and a cathode piled one upon another on a substrate and the said light-emitting layer comprises a phosphorescent dopant and the aforementioned indolocarbazole derivative as a host material. In general formula (3), L is an aromatic heterocyclic group of a fused-ring structure with a valence of (n+1), Ar1 to Ar3 each is an alkyl group, an aralkyl group, or a substituted or unsubstituted aromatic hydrocarbon or aromatic heterocyclic group, and n is an integer of 0-5.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: August 5, 2014
    Assignee: Nippon Steel & Sumikin Chemical Co., Ltd.
    Inventors: Takahiro Kai, Masaki Komori, Toshihiro Yamamoto
  • Publication number: 20140117289
    Abstract: The present invention describes copolymers containing indenocarbazole derivatives having electron- and hole-transporting properties, in particular for use in the interlayer, emission and/or charge-transport layer of electroluminescent devices, and the monomers which are necessary for the preparation of the copolymers. The invention furthermore relates to a process for the preparation of the copolymers according to the invention, and to electronic devices comprising same.
    Type: Application
    Filed: May 18, 2012
    Publication date: May 1, 2014
    Applicant: Merck Patent GmbH
    Inventors: Junyou Pan, Niels Schulte
  • Publication number: 20140077175
    Abstract: A condensed-cyclic compound and an organic light-emitting diode including the condensed-cyclic compound.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 20, 2014
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Hye-Jin Jung, Seok-Hwan Hwang, Young-Kook Kim, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Jun-Ha Park, Eun-Young Lee, Chang-Ho Lee, Jong-Hyuk Lee
  • Publication number: 20140077191
    Abstract: A compound is represented by a formula (1) below. In the formula (1), X1 to X8 each independently represent a carbon atom to be bonded to a group represented by the following formula (20), CRX or a nitrogen atom. At least one of X1 to X8 is a carbon atom to be bonded to the group represented by the following formula (2). RX is each independently a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 30 carbon atoms, or the like.
    Type: Application
    Filed: September 12, 2013
    Publication date: March 20, 2014
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Sayaka Mizutani, Takayasu Sado
  • Publication number: 20140072517
    Abstract: Compounds and uses of the compounds are provided. The compounds can be used as Fe(II) sequestering compounds. For example, these compounds can be used to sequester Fe(II) in cells, organs, vasculature, or tissues. Also, provided are compositions and methods of using the them for sequestering Fe(II) in an individual. The compounds can be used as MRI paraCEST contrast agents.
    Type: Application
    Filed: May 11, 2012
    Publication date: March 13, 2014
    Applicant: The Research Foundation of State University of New
    Inventors: Janet Morrow, Pavel Tsitovich
  • Publication number: 20140061600
    Abstract: A pyrene compound and an organic light emitting diode device including the same are disclosed. The organic light emitting diode device includes at least two stacks provided between a first electrode and a second electrode, and a charge generation layer provided between the stacks and including an N type charge generation layer and a P type charge generation layer, wherein the N type charge generation layer is made of the pyrene compound.
    Type: Application
    Filed: December 21, 2012
    Publication date: March 6, 2014
    Applicant: LG DISPLAY CO., LTD.
    Inventors: Shinhan Kim, Jeongdae Seo, Hyoseok kim, Youngkwan Jung, Eunju Jeon
  • Patent number: 8664396
    Abstract: A method of staining a poly(amino acid) by contacting a poly(amino acid) with an overall neutral or overall cationic complex of at least one of transition metal ion, and a plurality of donor ligands each of which is fully coordinated to the transition metal ion and is either a nitrogen donor ligand or a cyclometalated donor ligand, such that at least one of the donor ligands is a cyclometalated donor ligand. Nitrogen donor ligands will contain heteroaryl ring systems having from 10 to 40 ring atoms, wherein each nitrogen donor ligand is substituted with from 0 to 4 R1 groups. Cyclometalated donor ligands will likewise contain heteroaryl ring systems having from 10 to 40 ring atoms, such that at least one ring atom is N, wherein each cyclometalated donor ligand is substituted with from 0 to 4 R1 groups. R1, R2, R3 and R4 groups are defined herein.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: March 4, 2014
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Tom Berkelman
  • Publication number: 20140045793
    Abstract: The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein: R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 represents substituted or unsubstituted phenyl or the like; R4 represents halogen or the like; R5 represents hydrogen or the like; R6 represents hydrogen or the like; and R7 represents hydrogen or the like.
    Type: Application
    Filed: October 18, 2013
    Publication date: February 13, 2014
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Kenji OTSUBO, Takahito YAMAUCHI, Yuji OCHI
  • Publication number: 20140045873
    Abstract: The present invention provides compounds of formula (I) wherein A1, A2, R1, D1, D2, Y3 and X are as defined in the claims. The invention further relates to compositions which comprise these compounds and to their use in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
    Type: Application
    Filed: November 10, 2011
    Publication date: February 13, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Stephan Trah, Werner Zambach, Daniel Stierli, Kurt Nebel, Andrea Bortolato
  • Patent number: 8648194
    Abstract: The present invention provides a novel compound having a phenanthroline structure represented by formula (I) or a salt thereof:
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: February 11, 2014
    Assignee: B.R.A.H.M.S GmbH
    Inventors: Mikio Hoshino, Toshisada Yano
  • Publication number: 20140030172
    Abstract: The invention relates to novel compounds useful as ligands of actinides and which meet general formula (I) hereinafter: where: R1 and R2?H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; R3, R4, R5 and R6?H; a C1 to C12 hydrocarbon group; a monocyclic aryl or aryl-(C1 to C6)alkyl group; a —NR7R8 or —NR7COR8 group where R7?H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group, whilst R8=a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; an —OR9 or —SR9 group where R9=a C1 to C12 hydrocarbon group, a monocyclic C6 aryl or aryl-(C1 to C6)alkyl group. A further subject of the invention is a method for synthesizing these compounds and the uses thereof.
    Type: Application
    Filed: March 28, 2012
    Publication date: January 30, 2014
    Applicants: UNIVERSITE DE NANTES, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENE ALT
    Inventors: Julia Bisson, Marie-Christine Charbonnel, Nathalie Boubals, Manuel Miguirditchian, Denis Guillaneux, Dominique Guillaumont, Cecile Marie, Didier Dubreuil, Muriel Pipelier, Virginie Blot
  • Publication number: 20140014925
    Abstract: A compound represented by Formula 1 below and an organic light-emitting device including the compound are provided: Substituents in Formula 1 are the same as defined in the specification.
    Type: Application
    Filed: June 21, 2013
    Publication date: January 16, 2014
    Inventors: Hye-Jin Jung, Seok-Hwan Hwang, Young-Kook Kim, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Jun-Ha Park, Eun-Young Lee, Chang-Ho Lee, Jong-Hyuk Lee
  • Patent number: 8628863
    Abstract: Provided is an organic light-emitting device having an optical output with high luminance and high color purity with extremely high efficiency. The organic light-emitting device includes an organic layer between the anode and the cathode, in which one of the anode and the cathode is a transparent electrode or a semi-transparent electrode and at least one layer of the organic layer contains at least one kind of indenopyrene compound having a specific structure.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: January 14, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventors: Takeshi Sekiguchi, Hiroshi Tanabe, Hiroki Ohrui, Masanori Seki
  • Publication number: 20130292653
    Abstract: Embodiments of the present invention are directed to a condensed-cyclic compound represented by Formula 1, and to an organic light-emitting diode including the same.
    Type: Application
    Filed: November 27, 2012
    Publication date: November 7, 2013
    Applicant: Samsung Display Co. Ltd.
    Inventors: Bum-Woo Park, Yoon-Hyun Kwak, Sun-Young Lee, Se-Jin Cho
  • Publication number: 20130274471
    Abstract: A compound for an organic photoelectric device, an organic photoelectric device including the same, and a display device including the same the compound being represented by the following Chemical Formula 1:
    Type: Application
    Filed: June 12, 2013
    Publication date: October 17, 2013
    Inventors: Kyu-Yeon IN, Myeong-Soon KANG, Ho-Kuk JUNG, Nam-Soo KIM, Eui-Su KANG, Mi-Young CHAE, Jin-Seong PARK
  • Patent number: 8557401
    Abstract: To provide a novel chrysene compound and an organic light-emitting device having high emission efficiency and excellent driving durability, provided is a novel triaryl-substituted chrysene compound represented by the general formula [1]: wherein Ar1 to Ar3 each represent a substituent selected from the group consisting of a substituted or unsubstituted naphthyl group, a substituted or unsubstituted phenanthryl group, and a substituted or unsubstituted fluorenyl group.
    Type: Grant
    Filed: October 3, 2010
    Date of Patent: October 15, 2013
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tetsuya Kosuge, Jun Kamatani, Yosuke Nishide, Kengo Kishino
  • Publication number: 20130267708
    Abstract: Provided are a process for preparing an N ortho acyl substituted nitrogen-containing heterocyclic compound and an aminal iron (II) complex thereof, and the use of the complexes obtained by the process in an olefin oligomerization catalyst. The N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is for example 2-acyl-1,10-phenanthroline or 2,6-diacetyl pyridine as shown in formula b, and the N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is produced by a reaction of a precursor thereof in a substituted or unsubstituted nitrobenzene. Preferably the precursor shown in formula I in the present invention is produced by 1,10-phenanthroline reacting with trialkyl aluminum, or a halogenoalkyl aluminum RnAlXm, or a substituted or unsubstituted benzyl lithium 2Li, followed by hydrolysis.
    Type: Application
    Filed: December 1, 2011
    Publication date: October 10, 2013
    Inventors: Jun Liu, Mingfang Zheng, Weizhen Li, Haiying Zhang, Huaijie Wang, Yu Zhou, Tonglin Li, Lan Zhao, Hongfei Wu, Wingjun Xie, Chunhong Wu, Zhiguang Jia, Qi Yanping, Jilong Wang
  • Publication number: 20130217135
    Abstract: Disclosed is a compound suitable for use as a fluorescent probe for the detection of uranium. The compound enables the qualitative and quantitative analysis of uranium present in waste samples using less expensive apparatuses. The compound of the present invention has the structure shown by the following formula.
    Type: Application
    Filed: January 24, 2013
    Publication date: August 22, 2013
    Applicant: JAPAN ATOMIC ENERGY AGENCY
    Inventor: JAPAN ATOMIC ENERGY AGENCY
  • Patent number: 8512878
    Abstract: An organic EL device is provided that includes an emitting layer provided between an anode and a cathode. The emitting layer contains a diaminopyrene derivative represented by the following formula (1) as an emitting material for the organic EL device. The diaminopyrene derivative emits light with electrical energy.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: August 20, 2013
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventor: Masakazu Funahashi
  • Publication number: 20130180590
    Abstract: A compound represented by the following formula (1), wherein L is a single bond or a divalent group, and is bonded at any one of the 6th, 8th and the 9th positions indicated by * of 1,10-phenanthroline; Rg is a substituted or unsubstituted benzene ring or a substituted or unsubstituted naphthalene ring; and X is an oxygen atom or N—R4.
    Type: Application
    Filed: July 27, 2011
    Publication date: July 18, 2013
    Inventors: Keiichi Yasukawa, Ryoji Maeda, Hiroshi Tokailin
  • Publication number: 20130140544
    Abstract: This invention relates to deuterated indolocarbazole compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a deuterated compound.
    Type: Application
    Filed: January 24, 2013
    Publication date: June 6, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: E I DU PONT DE NEMOURS AND COMPANY
  • Patent number: 8455866
    Abstract: A heterocyclic compound of formula 1 and an organic light-emitting device including an organic layer containing the heterocyclic compound. The heterocyclic compound of Formula 1 may be suitable as a material for an emission layer, an electron transport layer or an electron injection layer of an organic light-emitting device. Due to the inclusion of the heterocylic group in its molecular structure, the heterocyclic compound of Formula 1 may have a high glass transition temperature (Tg) or a high melting point, and may prevent crystallization. An organic light-emitting device manufactured using the heterocyclic compound of Formula 1, which has a symmetrical structure in which a chrysene group and an indole group are fused, has excellent durability when stored or operated.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: June 4, 2013
    Assignee: Samsung Display Co., Ltd.
    Inventors: Hye-Jin Jung, Seok-Hwan Hwang, Young-Kook Kim, Yoon-Hyun Kwak, Jin-O Lim, Jong-Hyuk Lee
  • Publication number: 20130116272
    Abstract: The present invention is directed to heterocyclic fused phenanthrolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
    Type: Application
    Filed: June 10, 2011
    Publication date: May 9, 2013
    Inventors: Scott D. Kuduk, Jason W. Skudlarek
  • Publication number: 20130098770
    Abstract: Copper plating baths containing a leveling agent that is a reaction product of one or more of certain pyridine compounds with one or more epoxide-containing compounds, that deposit copper on the surface of a conductive layer are provided. Such plating baths deposit a copper layer that is substantially planar on a substrate surface across a range of electrolyte concentrations. Methods of depositing copper layers using such copper plating baths are also disclosed.
    Type: Application
    Filed: October 24, 2011
    Publication date: April 25, 2013
    Applicant: Rohm and Haas Electronic Materials LLC
    Inventors: Zuhra I. NIAZIMBETOVA, Maria Anna Rzeznik
  • Publication number: 20130072485
    Abstract: The present invention relates to small molecule modulators of mTORC1 and mTORC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases. Novel small molecules are provided that inhibit one or more of mTORC1, mTORC2, and PI3K-related proteins. Novel methods of providing soluble mTORC1 and mTORC2 complexes are discussed, as well as methods of using the soluble complexes in a high-throughput manner to screen for inhibitory compounds.
    Type: Application
    Filed: November 6, 2012
    Publication date: March 21, 2013
    Applicants: Dana-Farber Cancer Institute, Inc., Whitehead Institute for Biomedical Research
    Inventors: Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Inc.
  • Publication number: 20130001524
    Abstract: A heterocyclic compound represented by Formula 1 below and an organic light-emitting device including an organic layer that includes the following heterocyclic compound: wherein R1 to R13 are each independently a hydrogen atom, a heavy hydrogen atom, a substituted or unsubstituted C1-C60 alkyl group, a substituted or unsubstituted C2-C60 alkenyl group, a substituted or unsubstituted C2-C60 alkynyl group, a substituted or unsubstituted C3-C60 cycloalkyl group, a substituted or unsubstituted C1-C60 alkoxy group, a substituted or unsubstituted C5-C60 aryloxy group, a substituted or unsubstituted C5-C60 arylthio group, a substituted or unsubstituted C5-C60 aryl group, an amino group substituted with a C5-C60 aryl group or a C3-C60 heteroaryl group, a substituted or unsubstituted C3-C60 heteroaryl group, a substituted or unsubstituted C6-C60 condensed polycyclic group, a halogen atom, a cyano group, a nitro group, a hydroxy group, or a carboxy group.
    Type: Application
    Filed: December 8, 2011
    Publication date: January 3, 2013
    Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.
    Inventors: Jin-O Lim, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Sang-Hyun Han, Chang-Ho Lee, Jong-Hyuk Lee, Hee-Joo Ko
  • Publication number: 20130005675
    Abstract: The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein: R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 represents substituted or unsubstituted phenyl or the like; R4 represents halogen or the like; R5 represents hydrogen or the like; R6 represents hydrogen or the like; and R7 represents hydrogen or the like.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 3, 2013
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Kenji OTSUBO, Takahito YAMAUCHI, Yuji OCHI
  • Publication number: 20120328599
    Abstract: The present invention provides moieties that bind to the asymmetric contact interface of a receptor tyrosine kinase (RTK), wherein the moieties inhibit ligand induced trans autophosphorylation of the RTK. The present invention also provides methods of treating or preventing an RTK-associated disease and methods for identifying moieties that bind to an asymmetric contact interface of an RTK.
    Type: Application
    Filed: January 13, 2011
    Publication date: December 27, 2012
    Applicant: YALE UNIVERSITY
    Inventors: Jae Hyun Bae, Irit Lax, Joseph Schlessinger
  • Patent number: 8309731
    Abstract: There is provided an organic electronic device having an anode, a hole injection layer, a photoactive layer, an electron transport layer, and a cathode. At least one of the photoactive layer and the electron transport layer includes a compound having Formula I where: R1 is the same or different and can be phenyl, biphenyl, naphthyl, naphthylphenyl, triphenylamino, or carbazolylphenyl; and one of the following conditions is met: (i) R2=R3 and is H, phenyl, biphenyl, naphthyl, naphthylphenyl, arylanthracenyl, phenanthryl, triphenylamino, or carbazolylphenyl; or (ii) R2 is H or phenyl; and R3 is phenyl, biphenyl, naphthyl, naphthylphenyl, arylanthracenyl, phenanthryl, triphenylamino, and carbazolylphenyl; When both R1 are phenyl, R2 and R3 can be 2-naphthyl, naphthylphenyl, arylanthracenyl, 9-phenanthryl, triphenylamino, or m-carbazolylphenyl.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: November 13, 2012
    Assignee: E I du Pont de Nemours and Company
    Inventors: Norman Herron, Mark A. Guidry, Vsevolod Rostovtsev, Weiying Gao, Ying Wang, Yulong Shen, Jeffrey A. Merlo
  • Publication number: 20120270141
    Abstract: To provide nitrogen-containing aromatic compounds with excellent oxygen reduction activity, metal complexes containing them, and catalysts and electrodes employing the same, the present invention provides an aromatic compound satisfying the following conditions (a) and (b): (a) It has 2 or more structures surrounded by at least 4 coordinatable nitrogen atoms (which structures may be the same or different), (b) At least one of the nitrogen atoms composing the structure is a nitrogen atom in a 6-membered nitrogen-containing heterocyclic ring.
    Type: Application
    Filed: October 29, 2010
    Publication date: October 25, 2012
    Applicants: Max Planck Gesellschaft zur Foerderung der Wissenschaften e.V., SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Nobuyoshi Koshino, Hideyuki Higashimura, Klaus Muellen, Christian von Malotki, Qi Su, Martin Baumgarten, Hassan Norouzi-Arasi, Lena Arnold, Ruili Liu
  • Publication number: 20120238748
    Abstract: The present invention provides a novel compound having a phenanthroline structure represented by formula (I) or a salt thereof:
    Type: Application
    Filed: September 13, 2010
    Publication date: September 20, 2012
    Applicant: B.R.A.H.M.S GmbH
    Inventors: Mikio Hoshino, Toshisada Yano
  • Patent number: 8268856
    Abstract: The sponges were collected from a variety of locations in the Florida Keys and separated based on morphology and color. The samples were identified as three species, two of which are well known: V. rigida (Esper, 1794) (order Verongida, family Aplysinidae) and S. aurea (Hyatt, 1875) (order Dictyoceratida, family Thorectidae), and a third S. cerebriformis (Duchassaing & Michelotti, 1864), is less common and separated based on subtle differences of morphology and coloration, from the other two species. Several compounds were isolated and were evaluated in established animal models predictive of neurological related drug function, namely, the rodent FST and the chick anxiety-depression model.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: September 18, 2012
    Inventors: Mark T. Hamann, Anna J. Kochanowska, Abir El-Alfy, Rae R. Matsumoto, Angelo Boujos
  • Patent number: 8257981
    Abstract: Novel chemical compounds, with application in fluorometric analytical methods, for qualitative and quantitative determination of biomolecules. The aim of the invention is to identify and prove the suitability of such compounds. Said aim is achieved with compounds of formula (1) where R1 is an antenna function, R2 is a chelate forming agent, containing a coordinated lanthanide(III)ion, X is —OH or a group with affinity for the biomolecule, bonded to a carboxylate group of the chelate forming agent by means of an amide bond and Y is —H or a group with affinity for the biomolecule, coupled to the antenna function.
    Type: Grant
    Filed: April 30, 2005
    Date of Patent: September 4, 2012
    Assignee: Sensient Imaging Technologies GmbH
    Inventors: Jörg Marx, Frank Schumer, Regina Lischewski, Kornelia Zeckert, Hans-Joachim Böhme, Horst Hennig
  • Publication number: 20120211743
    Abstract: A benzo[k]fluoranthene derivative represented by the following formula (1): wherein R1 to R12 are as defined in the specification. The benzo[k]fluoranthene derivative represented by the formula (1) reduces a driving voltage of an organic electroluminescence device and makes it possible to realize light emission with high efficiency and long lifetime.
    Type: Application
    Filed: October 7, 2011
    Publication date: August 23, 2012
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Hirokatsu Ito, Masahiro Kawamura, Yuichiro Kawamura, Yumiko Mizuki, Hiroyuki Saito
  • Publication number: 20120208989
    Abstract: Fluorinated aromatic materials, their synthesis and their use in optoelectronics. In some cases, the fluorinated aromatic materials are perfluoroalkylated aromatic materials that may include perfluoropolyether substituents.
    Type: Application
    Filed: August 20, 2010
    Publication date: August 16, 2012
    Applicant: THE UNIVERSITY OF SOUTH DAKOTA
    Inventor: Haoran Sun
  • Publication number: 20120165532
    Abstract: This invention, which belongs to the field of organic synthesis, involves “One-step synthetic method of 2,9-dimethyl-1,7-diphenyl-1,10-phenanthroline”. This method uses O-phenylenediamine and formula III to react under the condition of mixed-shrinking agent, the synthesis can be completed in one step, the stated mixed-shrinking agent is mixture of hydrochloric acid and organic acid. The organic acid serves as phase transfer catalyst and shrinking agent, meanwhile, as buffer reagent, organic acid reduces polymerization of III, and side products as well. The products gained are of high purity and the reaction is mild and easy to control. Since there is no polluting material added and generated, the waste is safe to discharge. In the after treatment of reaction, ketone solvent is used to reduce separation step and product lost, thus improving yield.
    Type: Application
    Filed: March 30, 2010
    Publication date: June 28, 2012
    Inventors: Lifei Cai, Weilong Zhang, Hongyu Zhao, Lei Dai
  • Publication number: 20120129849
    Abstract: The present invention provides deuterated compounds having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. The deuterated compounds of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such deuterated compounds as therapeutic agents.
    Type: Application
    Filed: September 23, 2011
    Publication date: May 24, 2012
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Mustapha HADDACH, David M. Ryckman
  • Publication number: 20120108581
    Abstract: The present invention provides a low molecular weight compound having EPO production-promoting action and/or hemoglobin production-promoting action. The present invention relates to a fused piperidine compound represented by the following general formula (1): (wherein, ring A represents a C10-14 aryl group or 5- to 10-membered heterocyclic group, X represents N—R7, a sulfur atom or an oxygen atom, R1, R2, R2?, R3 and R3? independently represent a hydrogen atom, C1-6 alkyl group or C3-6 cycloalkyl group, and R4, R5 and R6 independently represent a hydrogen atom or halogen atom), or a salt thereof, or a solvate thereof.
    Type: Application
    Filed: March 25, 2010
    Publication date: May 3, 2012
    Applicant: Kowa Company, Ltd
    Inventors: Masanori Ashikawa, Toshiharu Morimoto, Hajime Yamada, Shunji Takemura, Tatsuaki Nishiyama, Takeshi Doi, Hiroyuki Ishiwata
  • Publication number: 20120100628
    Abstract: Platinum (II) terdentate or bidentate complexes with non-linear optical properties are provided. The complexes have a broadband spectral and temporal response, and strong reverse saturable absorption and two-photon absorption in the visible and the near-IR region. As such, the complexes are useful for organic light-emitting diodes and optical-switching or sensing devices.
    Type: Application
    Filed: October 21, 2011
    Publication date: April 26, 2012
    Applicant: NDSU RESEARCH FOUNDATION
    Inventors: Wenfang Sun, Bingguang Zhang, Rui Liu, Pin Shao, Zhiqiang Ji, Zhongjing Li