Azide Or Acyclic Nitrogen Containing Patents (Class 548/109)
  • Patent number: 10464908
    Abstract: Described are methods for purifying a 5-nitrotetrazolate solution with a copper(II) modified cation exchange resin. The method can be performed as a stand-alone system or as a system integrated into a continuous flow reactor.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: November 5, 2019
    Assignee: Pacific Scientific Energetic Materials Company
    Inventors: John W. Fronabarger, Jason B. Pattison, Lily F. W. Walsh
  • Patent number: 9440934
    Abstract: A method of manufacture of the primary explosive material copper(I) 5-nitrotetazolate (DBX-1) by a synthesis starting with 5-aminotetrazolate (5-AT); wherein, the synthesis provides intermediates acid copper salt of 5-NT and sodium 5-nitrotetrazolate (NaNT) sodium 5-nitrotetrazolate (NaNT)—that are both, free of any 5-aminotetrazolate (5-AT) starting material—such that the subsequent production of the DBX-1 is not inhibited. Further, this method utilizes an internal filter within the reactor—to minimize handling of explosively dangerous intermediates.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: September 13, 2016
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Neha Mehta, Karl Oyler, Gartung Cheng, Jerry Salan, Shannon Lenahan
  • Publication number: 20150104367
    Abstract: According to one embodiment, a catalyst includes a metal ion, and an acyclic ligand having at least one aza-containing moiety, where the ligand is complexed to the metal ion.
    Type: Application
    Filed: October 10, 2013
    Publication date: April 16, 2015
    Applicant: Lawerence Livermore National Security, LLC
    Inventors: William C. Floyd, III, Carlos A. Valdez, Roger Aines, Sarah Baker, Joe H. Satcher, JR.
  • Publication number: 20150065688
    Abstract: A method for generating layered structures is disclosed. The method comprises reacting an azide-functionalized material with an alkyne-functionalized material, one of which can be a nanoparticle or a microparticle and the other can be a substrate or another nanoparticle or microparticle. The method also includes generating layered structures having multiple layers which can be built up in multiple azide-alkyne reaction steps.
    Type: Application
    Filed: August 29, 2014
    Publication date: March 5, 2015
    Inventors: Regina Ragan, Sri Sivakumar, Raj Ganesh S. Pala, Arun Prakash Upadhyay
  • Publication number: 20150065723
    Abstract: The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to generate a catalytically active species, often under mild conditions and in high yields. In some cases, a wide variety of catalysts may be synthesized from a single catalyst precursor. Methods of the invention may also include the preparation of catalysts which, under reaction conditions known in the art, may have been difficult or impossible to prepare and/or isolate due to, for example, steric crowding at the metal center. The present invention also provides catalyst compositions, and precursors thereof, which may be useful in various chemical reactions including olefin metathesis. In some cases, methods of the invention may reduce the number of synthetic and purification steps required to produce catalysts and/or other reaction products, as well as reducing time, cost, and waste production.
    Type: Application
    Filed: September 8, 2014
    Publication date: March 5, 2015
    Inventors: Adam S. Hock, Richard R. Schrock
  • Patent number: 8927733
    Abstract: A sensor that includes a) a silicon (Si) substrate having a surface; and b) a monolayer of oligoethylene glycol (OEG) bonded to the surface via silicon-carbon bonds. Regions of the OEG monolayer distal to the surface are functionalized with a molecular probe serving as a recognition element for a bioanalyte. A method of making a silicon surface that recognizes a biological specimen includes 1) hydrosilylating with a mixture that includes an oligoethylene glycol (OEG) substituted with an alkene at one end of the OEG and capped at the opposing end of the OEG and an oligoethylene glycol (OEG) substituted with an alkene at one end of the OEG and an alkyne having a protecting group at the opposing end of the OEG and 2) removing the protecting group from the alkyne; and 3) reacting the alkyne with a reagent in a 1,3-dipolar cycloaddition.
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: January 6, 2015
    Assignee: University of Houston
    Inventors: Chengzhi Cai, Chi Ming Yam, Jianhua Gu
  • Publication number: 20140341805
    Abstract: A method of imaging a region in a subject includes administering to the subject a complex of a metal chelated to a compound, and obtaining an image of the region in the subject.
    Type: Application
    Filed: July 29, 2014
    Publication date: November 20, 2014
    Applicant: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
    Inventors: John W. BABICH, Craig ZIMMERMAN, John JOYAL, Kevin P. MARESCA, John MARQUIS, Genliang LU, Jian-cheng WANG, Shawn HILLIER
  • Publication number: 20140315079
    Abstract: A method for preparing an imidazole compound with the following formula: wherein Rf is a fluorinated alkyl group comprising between 1 and 5 carbon atoms, said method including: (a) the reaction of the diaminomaleonitrile with the following formula: with the compound with the following formula: wherein Y represents a chlorine atom or the OCORf group to form the salified amide compound with the following formula: at temperature T1, and (b) the dehydration of the salified amide compound with formula (IVa) and/or the corresponding amino (IVb) to form the imidazole compound with formula (III), at temperature T2 higher than T1.
    Type: Application
    Filed: October 29, 2012
    Publication date: October 23, 2014
    Inventors: Gregory Schmidt, Miguel Flasque
  • Publication number: 20140220349
    Abstract: The present invention discloses a metal nickel-imidazolate chiral nano clathrate complex and preparation method thereof. The new type of metal nickel-imidazolate chiral nano clathrate complex of the present invention has the following chemical formula: [Ni14(Im)24].4NO3, in which Im is N-1-methyl-(4-imidazole) methylene imine. The complex can be obtained directly from a reaction of starting materials or prepared through first initiating a reaction between the compound ligand Im and a nickel salt under solvothermal conditions, and the complex obtained is of higher purity. The nano clathrate complex of the present invention has single chirality, and higher thermal stability, and thus has potential application in chiral catalytic materials.
    Type: Application
    Filed: September 14, 2011
    Publication date: August 7, 2014
    Applicant: Golight, Inc.
    Inventors: Dan LI, Xiaoping Zhou, Jie Liu
  • Publication number: 20140221645
    Abstract: N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 7, 2014
    Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LP
    Inventors: Orson L. Sydora, Michael Carney, Brooke L. Small, Jeffery C. Gee, Steven Hutchison
  • Publication number: 20140200348
    Abstract: A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.
    Type: Application
    Filed: September 20, 2012
    Publication date: July 17, 2014
    Applicant: Dow Corning Corporation
    Inventors: Kurt Brandstadt, Simon Cook, Avril Surgenor, Richard Taylor, Ming-Shin Tzou, Binh Nguyen
  • Patent number: 8753743
    Abstract: The invention relates to a material composed of nanoparticles essentially comprising a spin transition compound. The compound corresponds to the formula [ ( Fe 1 - y ? M y ? L 3 ) w ? L 3 ] [ X 2 x ? ( 1 - z x ? ) ? Y 2 ? ? z x ? ] w in which L represents a 1,2,4-triazole ligand carrying an R substituent on the nitrogen in the 4 position; X is an anion having the valency x, 1?x?2; Y is an anion other than X having the valency x?, 1?x??2; R is an alkyl group or an R1R2N— group in which R1 and R2 represent, each independently of the other, H or an alkyl radical; M is a metal having a 3d4, 3d5, 3d6 or 3d7 configuration, other than Fe; 0?y?1; 0?z?2; 3?w?1500. Applications: thermochromic pigment, data storage, optical limiters, contrast agent.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 17, 2014
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Francois Letard, Olivier Nguyen, Nathalie Daro
  • Publication number: 20140127138
    Abstract: Composition and method for surface-functionalized SPION-based agents. Such agents can provide highly pH-sensitive MRI contrast in tissue.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 8, 2014
    Applicant: Board of Trustees of Southern Illinois University
    Inventors: Yong Gao, Boyd Goodson
  • Patent number: 8709599
    Abstract: A material is composed of at least one spin transition compound that corresponds to the formula Fe1-mMm(R-Trz)3XbYc (I) in which M is a metal having a 3d4, 3d5, 3d6 or 3d7 configuration, other than Fe; 0?m?1; R-Trz represents a 1,2,4-triazole ligand carrying an R substituent on the nitrogen in the 4 position; R is an alkyl group or an R1R2N— group in which R1 and R2 represent, each independently of the other, H or an alkyl radical; X represents at least one noncoloring monovalent or divalent anion; Y represents at least one anion which has a coloring group; and b and c are chosen so that the electrical neutrality of the compound (I) is adhered to. A process for the preparation of this material and to its use as thermochromic pigment, as support for data storage or as optical limiter.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: April 29, 2014
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-François Letard, Nathalie Daro, Sandie Auffret
  • Publication number: 20140088312
    Abstract: The present invention discloses zeolite metal bis(imidazole) coordination polymers and preparation method thereof. The new class of zeolite coordination polymers of the present invention is a chemical compound with the following general chemical formula {[M(Blm)]×xDMF×yC2H6O×zH2O}?, in which when M=Zn, x=0.9, y=0, z=0; when M=Cu, x=1.2, y=0, z=0; when M=Mn, x=2.0, y=0, z=0; when M=Ni, x=0.4, y=1.2, z=1.0, Blm is 1,2-bis((5H-imidazol-4-yl)methylene)hydrazine, DMF is N,N-dimethyl formamide, H2O is water. A solvothermal method or slow diffusion is used on the compounds to obtain crystals of high purity. The coordination polymers of the present invention have good thermal stability, and have strong adsorption performance for CO2 under conditions of 0° C. and normal pressure as adsorbent materials.
    Type: Application
    Filed: September 14, 2011
    Publication date: March 27, 2014
    Inventors: Dan Li, Xiaoping Zhou, Jie Liu
  • Patent number: 8680003
    Abstract: N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: March 25, 2014
    Assignee: Chevron Phillips Chemical Company LP
    Inventors: Orson L. Sydora, Michael Carney, Brooke L. Small, Jeffery C. Gee, Steven Hutchison
  • Publication number: 20140058106
    Abstract: Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes. Also described herein are compositions and kits containing compounds and palladium complexes described herein.
    Type: Application
    Filed: July 29, 2013
    Publication date: February 27, 2014
    Inventors: Tobias Ritter, Takeru Furuya, Hanns M. Kaiser
  • Publication number: 20130296574
    Abstract: A sensor that includes a) a silicon (Si) substrate having a surface; and b) a monolayer of oligoethylene glycol (OEG) bonded to the surface via silicon-carbon bonds. Regions of the OEG monolayer distal to the surface are functionalized with a molecular probe serving as a recognition element for a bioanalyte. The molecular probe is covalently bonded in these regions as a cycloadduct of a 1,3-dipolar cycloaddition reaction. A composition having use as a catalyst for a 1,3-dipolar cycloaddition reaction includes Cu(I) and a triazole ligand having an oligoethylene glycol substituent.
    Type: Application
    Filed: March 25, 2013
    Publication date: November 7, 2013
    Inventors: Chengzhi Cai, Chin Ming Yam, Jianhua Gu
  • Patent number: 8563739
    Abstract: The invention relates to a novel class of ruthenium complexes containing phosphine and hybrid amine ligands, their preparation and use as catalysts in the reduction of simple ketones to alcohols by molecular hydrogenation. The reactivity and enantioselectivity of such complexes in the asymmetric hydrogenation of simple ketones could be enhanced by the addition of some selective additives.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: October 22, 2013
    Assignees: Enantiotech Corporation Limited, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    Inventors: Christian A Sandoval, Yue-hui Li
  • Publication number: 20130224225
    Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.
    Type: Application
    Filed: April 29, 2013
    Publication date: August 29, 2013
    Applicant: Yeda Research and Development Co., Ltd.
    Inventor: Yeda Research and Development Co., Ltd.
  • Publication number: 20130213822
    Abstract: The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.
    Type: Application
    Filed: September 25, 2012
    Publication date: August 22, 2013
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Roche Diagnostics Operations, Inc.
  • Publication number: 20130204005
    Abstract: Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matter provide methods for preparing lead-free primary explosives. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. Certain embodiments of the present subject matter also provide methods for preparing copper(I) nitrotetrazolate. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture.
    Type: Application
    Filed: September 13, 2012
    Publication date: August 8, 2013
    Applicant: PACIFIC SCIENTIFIC ENERGETIC MATERIALS COMPANY
    Inventors: John W. Fronabarger, Michael D. Williams, William B. Sanborn
  • Publication number: 20130127947
    Abstract: The invention relates to a treatment for printing a surface with an ink that comprises a compound that exhibits a change of electronic spin state as a function of temperature, imparting optical properties such that the ink is visible in a temperature range that includes an ambient temperature of around 20° C. and is transparent in the visible spectrum when the ink is brought to a temperature above said range and then brought back down to a temperature within the range.
    Type: Application
    Filed: July 21, 2011
    Publication date: May 23, 2013
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventor: Jean-Francois Letard
  • Publication number: 20130090472
    Abstract: The invention provides compounds of the Formula (I), in which W is independently selected from W1, W2, W3, W4, W5, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Zn—Zn bonds (n=4-17; n?=n+1) are optionally of any whole or partial bond order, Y is Y1 or Y represents a pair of substituents independently selected from H, C-1-C6 alkyl, Z5 or Z6 aryl, or Y is optionally a bridging structure that may comprise one or more C-1-C6 amide, C-1-C6 ether, or C-1-C6 ester groups, R-R39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C5-C6 aryl, C1- C-12 alkyl, amine, C-1-C6 alkylamine, C-1-C6 amide, nitro, cyano, carboxyl, C-1-C6 ester, phosphane, thiol, C-1-C6 thioether, OR?, and suitable pairs of adjacent R groups (R-R39) may optionally together form part of a C5 or C6 aryl ring, a Z5 or Z6 ring, R? is independently selected from H, C-1-C6 alkyl, Z5 or Z6 aryl, C-1-C6 ester,
    Type: Application
    Filed: June 14, 2011
    Publication date: April 11, 2013
    Applicant: UNIVERSITY OF KWAZULU-NATAL
    Inventors: Orde Quentin Munro, Kate Julie Akerman, Piers Akerman
  • Publication number: 20130090478
    Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
    Type: Application
    Filed: November 30, 2012
    Publication date: April 11, 2013
    Inventor: Jannsen Pharmaceutica, N.V.
  • Publication number: 20130066128
    Abstract: The present invention describes a novel catalytic composition comprising at least one nickel complex, said complex being obtained from a mixture comprising at least one nickel precursor A with at least one imino-imidazole ligand B and a method of oligomerization of olefins using said catalytic composition.
    Type: Application
    Filed: September 5, 2012
    Publication date: March 14, 2013
    Applicant: IFP Energies nouvelles
    Inventors: Pierre-Alain BREUIL, Adrien BOUDIER, Lionel MAGNA, Helene OLIVIER-BOURBIGOU
  • Patent number: 8383673
    Abstract: The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: February 26, 2013
    Assignees: City University of Hong Kong, Versitech Limited
    Inventors: Tai Chu Lau, Yun Wah Lam, Wai Lun Man, Wen Xiu Ni, Chi-Ming Che
  • Publication number: 20130011680
    Abstract: The invention relates to a material composed of nanoparticles essentially comprising a spin transition compound. The compound corresponds to the formula [ ( Fe 1 - y ? M y ? L 3 ) w ? L 3 ] [ X 2 x ? ( 1 - z x ? ) ? Y 2 ? ? z x ? ] w in which L represents a 1,2,4-triazole ligand carrying an R substituent on the nitrogen in the 4 position; X is an anion having the valency x, 1?x?2; Y is an anion other than X having the valency x?, 1?x??2; R is an alkyl group or an R1R2N— group in which R1 and R2 represent, each independently of the other, H or an alkyl radical; M is a metal having a 3d4, 3d5, 3d6 or 3d7 configuration, other than Fe; 0?y?1; 0?z?2; 3?w?1500. Applications: thermochromic pigment, data storage, optical limiters, contrast agent.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Centre National De La Recherche Scientifique
    Inventors: Jean-François LETARD, Olivier NGUYEN, Nathalie DARO
  • Publication number: 20120309965
    Abstract: N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.
    Type: Application
    Filed: December 29, 2010
    Publication date: December 6, 2012
    Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LP
    Inventors: Orson L. Sydora, Michael Carney, Brooke L. Small, Jeffery C. Gee, Steven Hutchison
  • Publication number: 20120271018
    Abstract: The present invention provides imino carbene compounds and their derivatives, catalyst compositions containing these compounds in combination with an activator, and polymerization processes using these catalyst compositions to polymerize one or more olefins.
    Type: Application
    Filed: April 10, 2012
    Publication date: October 25, 2012
    Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LP
    Inventors: Rex E. Murray, LeGrande Mancel Slaughter, III, Dipesh Prema, Jinhui Chen
  • Publication number: 20120215004
    Abstract: Described are compounds and materials that may be used as a lead-free primary explosive,such as copper(I) nitrotetrazolate. Copper(I) nitrotetrazolate may he prepared by a process comprising the steps of: combining cupric salt, water and 5-nitrotetrazolate salt to form a mixture, heating the mixture, adding a reducing agent and stirring with continued heating. The method may also include combining cupric chloride, sodium 5-nitrotetrazolate and sodium ascorbate.
    Type: Application
    Filed: March 14, 2012
    Publication date: August 23, 2012
    Applicant: PACIFIC SCIENTIFIC ENERGETIC MATERIALS COMPANY
    Inventors: JOHN W. FRONABARGER, Michael D. Williams
  • Publication number: 20120172566
    Abstract: A metal cyanide complex catalyst and its preparation and application are disclosed. The formula of this catalyst is M1a[M2(CN)bL1c]d(X)m(L2)n·xSu·yL3·zH2O and its preparation method comprises: (A) adjusting pH of a mixed solution I? of L3, M3e[M2(CN)bL1c]f, de-ionized water I, alcohol and/or ether solvent to less than 7.0, and adding it into a mixed solution II? of M1(X)g salt, Su or Su precursor, de-ionized water II, stirring for reaction under 20° C.-120° C. for 0.5-200 hours, separating and drying to obtain a solid product; and (B) repeatedly dispersing the solid into an anhydrous organic solvent containing L2 to form a slurry, distilling, separating and drying to obtain the metal cyanide complex catalyst. The catalyst is useful in preparing polyethers, polycarbonates and polyesters by homopolymerization of epoxides, or copolymerization of epoxides with carbon dioxide or anhydrides.
    Type: Application
    Filed: December 13, 2010
    Publication date: July 5, 2012
    Applicant: ZHEJIANG University
    Inventors: Xinghong Zhang, Guorong Qi, Binyang Du, Renjian Wei, Xueke Sun
  • Patent number: 8211402
    Abstract: A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus, pharmaceutical compositions may be prepared with one or more of the compounds of Formula I, II, III, or IV.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: July 3, 2012
    Assignee: Molecular Insight Pharmaceuticals, Inc.
    Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
  • Patent number: 8211401
    Abstract: A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof: complexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, particularly where the metal is radioactive. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: July 3, 2012
    Assignee: Molecular Insight Pharmaceuticals, Inc.
    Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
  • Publication number: 20120108820
    Abstract: Novel chemical compounds of the general formula K+A? useful as industrial solvents, especially as ligands, for efficient catalyst recycling.
    Type: Application
    Filed: December 16, 2011
    Publication date: May 3, 2012
    Inventors: Paul Dyson, Dongbin Zhao, Zhaofu Fei
  • Publication number: 20120034165
    Abstract: The present invention provides novel compounds which may be used as in vivo imaging agents. The compounds of the invention are useful in a method to image the expression of P2X7 receptors in a subject, as a means to facilitate the diagnosis of a range of disease states.
    Type: Application
    Filed: April 6, 2010
    Publication date: February 9, 2012
    Inventors: ALexander Jackson, Véronique Morisson-Iveson
  • Publication number: 20110319630
    Abstract: This disclosure relates to porous frameworks for gas separation, sensing and drug/biomolecule delivery. More particularly, the disclosure relates to reactive porous frameworks for functionalization.
    Type: Application
    Filed: December 18, 2009
    Publication date: December 29, 2011
    Applicants: BASF SE, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Omar M. Yaghi, Alexader U. Czaja, William Morris, Joseph R. Hunt, David Kyle Britt, Chain Lee
  • Publication number: 20110311884
    Abstract: The invention relates to a pentacyclic anion salt and to the use thereof in electrolyte compositions. The compound comprises an inorganic, organic or organometallic cation M of valency m (1?m?3) and m anions corresponding to the formula (I) in which Rf is a —CFZ?Z? group in which Z? is F or a perfluoroalkyl group having from 1 to 3 carbon atoms, and Z? is an H, F or Cl group, an optionally fluorinated or perfluorinated alkoxy group having from 1 to 5 carbon atoms, an optionally fluorinated or perfluorinated oxaalkoxy group having from 1 to 5 carbon atoms or an optionally fluorinated or perfluorinated alkyl group having from 1 to 5 carbon atoms; Z? being other than F when Z? is F. An electrolyte composition comprises said salt in solution in a liquid solvent or a polymer solvent.
    Type: Application
    Filed: August 28, 2009
    Publication date: December 22, 2011
    Inventors: Michel Armand, Sylvie Grugeon, Stephane Laruelle, Maria Bukowska, Przemyslaw Szczecinski, Wladyslaw Wieczorek, Leszek Niedzicki, Bruno Scrosati, Stefania Panero, Priscilla Realle
  • Publication number: 20110301354
    Abstract: Lead-free primary explosives of the formula [MII(A)R(BX)S](CY)T, where A is 1,5-diaminotetrazole, and syntheses thereof are described. Substantially stoichiometric equivalents of the reactants lead to high yields of pure compositions thereby avoiding dangerous purification steps.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 8, 2011
    Applicant: LOS ALAMOS NATIONAL SECURITY, LLC
    Inventor: My Hang V. Huynh
  • Patent number: 8017599
    Abstract: The present invention relates to sequence selective compounds for targeting therapeutic or diagnostic groups to polynucleotides. More particularly, the present invention relates to sequence selective targeting of metallocomplexes, such as metallodrugs and metallodiagnostics, to polynucleotides.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: September 13, 2011
    Assignee: University of Western Sydney
    Inventors: David Jaramillo, Craig Brodie, Warren Howard, Robin Taleb, Janice Aldrich-Wright
  • Publication number: 20110207902
    Abstract: The present invention generally relates to metal-ligand complexes, catalysts comprising or prepared from the metal-ligand complexes, processes of catalyzing olefin polymerization reactions with the catalysts to prepare polyolefins, polyolefins prepared thereby, processes of making the metal-ligand complexes and catalysts, and intermediate compounds useful therefor.
    Type: Application
    Filed: February 8, 2011
    Publication date: August 25, 2011
    Inventors: Jerzy Klosin, Ruth Figueroa, Philip P. Fontaine
  • Patent number: 7812042
    Abstract: Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, N-acetyl-L-cysteinylcobalamin (NACCbl) to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as NACCbl, in lieu of current, commercially available forms of vitamin B12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: October 12, 2010
    Assignees: Kent State University, University of Chester
    Inventors: Nicola E. Brasch, Catherine Stephanie Birch, John Henry Howatson Williams
  • Publication number: 20100233188
    Abstract: The present invention relates to a compound having the general Formula (I): wherein: m and n are each independently an integer from 1 to 6; X1-X3 and Y1-Y3 are each independently O or S; R1-R3 are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and R is (CH2)x—C(?O)NR?—(CH2)y—NR?R? whereas: x and y are each independently an integer from 1 to 6; and R? and R? are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and to an antibody comprising an antigen recognition region capable of specifically binding the above compound.
    Type: Application
    Filed: February 21, 2008
    Publication date: September 16, 2010
    Inventors: Irit Sagi, Tamar Danon, Netta Sela, Abraham Shanzer, Rina Arad-Yellin, Raghavendra Kikkeri
  • Publication number: 20100228031
    Abstract: The invention provides ruthenium-comprising catalysts, and methods of making and using them, for conjugating double bonds in polyunsaturated hydrocarbons, including polyunsaturated fatty acid derivatives, such as natural fats and oils which comprise (contain) more than one carbon to carbon double bond—where the double bonds are separated by, e.g., a methylene, ethylene or propylene or longer group. The invention provides compositions and methods for treating fats and oils comprising “interrupted” (e.g., “methylene-, ethylene- or propylene-interrupted”) double bonds to generate isomers with “conjugated” double bonds. The invention also provides compositions, and methods of making and using them, for making catalysts on a solid support. In one aspect, these catalysts are for alkene isomerization or exchange of alkene hydrogens for other isotopes.
    Type: Application
    Filed: July 25, 2008
    Publication date: September 9, 2010
    Applicant: SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION
    Inventor: Douglas Grotjahn
  • Publication number: 20100178246
    Abstract: A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof: complexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, particularly where the metal is radioactive. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.
    Type: Application
    Filed: December 4, 2009
    Publication date: July 15, 2010
    Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
  • Publication number: 20100178247
    Abstract: A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus, pharmaceutical compositions may be prepared with one or more of the compounds of Formula I, II, III, or IV.
    Type: Application
    Filed: December 4, 2009
    Publication date: July 15, 2010
    Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
  • Publication number: 20100152154
    Abstract: A series of platinum compounds and methods of treating cancer by said platinum compounds are disclosed.
    Type: Application
    Filed: December 12, 2009
    Publication date: June 17, 2010
    Inventors: Jiajiu Shaw, Fenlai Tan
  • Patent number: 7687490
    Abstract: An objective of the present invention is to provide compounds that are effective against various resistant bacteria which cause current clinical problems, for example, pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP), Haemophilus influenzae including bata-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: March 30, 2010
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Takahisa Maruyama, Yuko Kano, Takashi Ando, Takehiko Sawabe, Nobuyoshi Baba, Hiromi Takata, Hisashi Suzuki, Kazuhiro Aihara, Toshiki Fujita
  • Publication number: 20100063295
    Abstract: The present invention provides a compound of the formula (Cat)+z[M++(5-nitro-1H-tetrazolato-N2)?x(H2O)y] where x is 3 or 4, y is 2 or 3, x+y is 6, z is 1 or 2, and M++ is selected from the group consisting of iron, cobalt, nickel, copper, zinc, chromium, and manganese, and (Cat)+ is selected from the group consisting of ammonium, sodium, potassium, rubidium and cesium. A method of preparing the compound of that formula is also disclosed.
    Type: Application
    Filed: February 26, 2009
    Publication date: March 11, 2010
    Inventors: Michael A. Hiskey, My Hang V. Huynh
  • Publication number: 20090206245
    Abstract: It is an object of the present invention to provide a novel mass spectrometry method which overcomes the conventional problems mentioned above, which can analyze at a high sensitivity and high accuracy a chemical reaction on a surface of a self-organized membrane bound to a metal, and which can be applied to analysis of structures of a sugar chain in future. According to the present invention, a method for performing mass spectrometry of sulfur atom-containing derivatives of an organic residue, characterized in that the method includes ionizing a metal-organic residue complex into the derivatives, wherein the complex has the organic residue bound through a sulfur atom to the metal is provided, thereby solving the above problems.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 20, 2009
    Applicant: Shionogi CO., Ltd
    Inventors: Noriko Nagahori, Kenichi Niikura, Shinichiro Nishimura