Tricyclo Ring System Having The Thiazole Ring As One Of The Cyclos Patents (Class 548/150)
  • Patent number: 4556411
    Abstract: Benzothiazole compounds of the following structural formula modify the growth and development of plants: ##STR1## wherein U is selected from -hydrogen, -halogen, -lower alkyl, -lower haloalkyl, -lower alkoxy, -phenyl, and -phenoxy optionally carrying -halogen and -lower haloalkyl substituents;V is selected from -hydrogen and -halogen, or U and V taken together are --C.sub.4 H.sub.4 -- joining adjacent ring positions;Y is selected from -hydrogen and -lower alkoxy;Z is cyclic and either (a) -phenyl optionally carrying 1 or 2 substituents independently selected from -halogen, -nitro, or two substituents taken together are --C.sub.4 H.sub.4 -- joining adjacent ring positions, or (b) Z may be a saturated or partially unsaturated carbocycle, optionally carrying a bicyclic --CH.sub.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: December 3, 1985
    Assignee: FMC Corporation
    Inventors: Jonathan S. Baum, Tsong M. Chen
  • Patent number: 4547579
    Abstract: There are described novel dyes of the formulae ##STR1## in which R.sub.1 and R.sub.2 independently of one another are each hydrogen, unsubstituted or substituted alkyl, cycloalkyl, aralkyl or aryl, and R.sub.1 and R.sub.2 together with the nitrogen atom, and optionally with the inclusion of further hetero atoms, can also form a 5- to 7-membered heterocycle, or one of the radicals R.sub.1 or R.sub.2 can be linked with the carbon atoms, in the o-position with respect to the amino group, of the ring A to form a fused-on, saturated, unsubstituted or substituted 5- or 6- membered ring,X is .dbd.NR.sub.3, .dbd.NCOR.sub.4, ##STR2## .dbd.NH or .dbd.O, wherein R.sub.3 is alkyl or unsubstituted or substituted phenyl,R.sub.4 is unsubstituted or substituted alkyl, aralkyl, aryl, vinyl, alkoxy, phenoxy or amino, andR.sub.5 is cyano, carbalkoxy, or unsubstituted or substituted carbonamide, andR.sub.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: October 15, 1985
    Assignee: Ciba-Geigy Corporation
    Inventor: Peter Mockli
  • Patent number: 4539408
    Abstract: Quaternary sulfoalkyl or sulfoalkenyl salts of tertiary amine bases are prepared by reacting the tertiary amine bases at elevated temperatures with a hydroxy alkane sulfonic acid or a hydroxyalkene sulphonic acid.
    Type: Grant
    Filed: April 28, 1978
    Date of Patent: September 3, 1985
    Assignee: Agfa-Gevaert Aktiengesellschaft
    Inventors: Helmut Kampfer, Marie Hase, Max Glass
  • Patent number: 4517196
    Abstract: Thiazolyloxamic acids and their derivatives of the general formula I ##STR1## processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful as drugs for treating allergic disorders.
    Type: Grant
    Filed: August 26, 1982
    Date of Patent: May 14, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Rainer Schlecker, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4515955
    Abstract: Isoindoline derivatives monosubstituted in the 1-position corresponding to the general formula ##STR1## in which the cyclic radical R is an aromatic ring, a substituted aromatic ring, a tetrahydrogenated aromatic ring, a nitrogen-containing heterocyclic ring, or a sulfur-containing heterocyclic ring, and R.sub.1 is a substituent represented by the general formula ##STR2## where Y is an atom of oxygen, nitrogen, sulfur, or carbon, Z is the atom or atoms necessary to form a 5-membered or 6-membered heterocyclic ring which may have a fused-on aromatic ring selected from phenyl and naphthyl groups, R.sub.2 is an alkyl, sulfoalkyl, or carboxyalkyl radical, and X.sup.- is the anion for the cationic quaternary nitrogen. The derivatives are dyes having hydrophilic properties. They are useful for dyeing and printing textile fibers and for photographic applications.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: May 7, 1985
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Robert F. Coles
  • Patent number: 4504668
    Abstract: Tertiary amines may be quaternized by heating them with a sulfoalkylating agent of this invention to a temperature of from 100.degree. to 250.degree. C. The sulfoalkylating agents which are believed to be hydroxy alkane sulfonic acid sulfoalkyl esters are free from sultone and are prepared by heating a hydroxy alkane sulfonic acid of propane or butane or the corresponding sultone to a temperature in the region of from 80.degree. to 180.degree. C. in the presence of water in an amount of 1 to 4 moles per mole of hydroxy alkane sulfonic acid or alkane sultone.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: March 12, 1985
    Assignee: Agfa-Gevaert Aktiengesellschaft
    Inventors: Helmut Kampfer, Marie Hase, Max Glass
  • Patent number: 4497817
    Abstract: A novel 2-phenylimidazo[2,1-b]benzothiazole derivative shown by the following formula ##STR1## or a salt thereof which possesses an immunoregulatory action and is useful as an antiallergic agent, an antiasthmatic, and a suppressant of rejection at tissue transplantation and skin graft.
    Type: Grant
    Filed: April 26, 1983
    Date of Patent: February 5, 1985
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kiyoshi Murase, Toshiyasu Mase, Kenichi Tomioka
  • Patent number: 4443610
    Abstract: Bicyclothiazoles having the structure: ##STR1## wherein n is 3, 4, or 5R.sub.1 is hydrogen or alkyl,R.sub.2 is hydrogen, alkyl, hydroxyl, alkoxy, cyano, phenyl, carboxyl, tetrazole, or halogen,R.sub.3 is tetrazole, carboxamide or ##STR2## wherein Z is oxygen, sulfur, or NH andR.sub.4 is H, alkali metal, ammonium, alkyl, alkoxyalkyl, aryl, or aralkyl,are novel and useful as antiallergic agents. The compounds are formulated with a pharmaceutical carrier for oral, parental, inhalational, or rectal means of administration.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: April 17, 1984
    Assignee: USV Pharmaceutical Corporation
    Inventor: Fu-chih Huang
  • Patent number: 4440935
    Abstract: Bicycloimidazoles having the structure: ##STR1## wherein n is 3, 4, or 5R.sub.1 is hydrogen or alkyl,R.sub.2 is hydrogen, alkyl, hydroxyl, alkoxy, cyano, phenyl, carboxyl, tetrazole, or halogen,R.sub.3 is tetrazole, carboxamide or ##STR2## wherein Z is oxygen, sulfur, or NH andR.sub.4 is H, alkali metal, ammonium, alkyl, alkoxyalkyl, aryl, or aralkyl,are novel and useful as antiallergic agents. The compounds are formulated with a pharmaceutical carrier for oral, parental, inhalational, or rectal means of administration.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: April 3, 1984
    Assignee: USV Pharmaceutical Corporation
    Inventor: Fu-chih Huang
  • Patent number: 4429134
    Abstract: A process for the manufacture of a 2(3H)-benzothiazolone compound substituted in 3-position, or of a 2(3H)-naphthothiazolone compound substituted in 3-position which comprises treating a 2(3H)-iminobenzothiazoline compound substituted in 3-position or a 2(3H)-naphthothazoline compound substituted in 3-position with an alkali metal hydroxide or alkaline earth metal hydroxide in a solvent or diluent stable to alkalis, in the absence of water or with substantial exclusion of water, and cyclizing the alkali metal or alkaline earth metal salt of the ortho-mercapto-N-phenyl- or -naphthyl-urea compound substituted at the nitrogen atom so formed, optionally without intermediate isolation, by treatment with an acid to give the 2(3H)-benzothiazolone compound substituted in 3-position or the 2(3H)-naphthothiazolone compound substituted in 3-position. The process furnishes the final products with high yield and purity; waste water problems are excluded by this process.
    Type: Grant
    Filed: May 18, 1981
    Date of Patent: January 31, 1984
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Theodor Papenfuhs
  • Patent number: 4380629
    Abstract: Styryl-like compounds showing improved stability and prolonged lifetime on repetition of the coloration and bleaching cycle and represented by the general formula ##STR1## in which R represents an alkyl or phenyl group, R.sub.1 and R.sub.2 independently represent a lower alkyl group, a hydroxyalkyl group, or an alkoxyalkyl group, R.sub.3 represents hydrogen, an alkyl group, a halogen, a nitrile group, an aromatic group or a phenoxy group, Y represents O or S, Z represents an alkylene radical of 2 to 4 carbon atoms, with or without alkyl substituent(s), necessary for forming a ring structure together with ##STR2## A represents a residue of an aromatic aldehyde, a heterocyclic aldehyde, an aromatic nitroso compound or a heterocyclic nitroso compound, and n is an integer of 2 or 3.
    Type: Grant
    Filed: April 20, 1981
    Date of Patent: April 19, 1983
    Assignee: Matsushita Electric Industrial Company, Limited
    Inventors: Akio Yamashita, Masaaki Hayami
  • Patent number: 4368201
    Abstract: Compounds having the structure: ##STR1## are novel and useful as antiallergic agents. The compounds are formulated with a pharmaceutical carrier for oral, parental, inhalational, or rectal means of administration.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: January 11, 1983
    Assignee: USV Pharmaceutical Corporation
    Inventor: Fu-chih Huang
  • Patent number: 4314058
    Abstract: This invention relates to color-changing stryl-like compounds and the preparing of the same. A compound according to the present invention has, as its principal ring, an indoline ring of 2nd position, and has, at stimulation reversible or irreversible change(s) between a closed ring structre of a non-plane molecular structure indicated by the following chemical formula(1) showing white or pale color, and an open ring structure of a plane molecular structure indicated by the following chemical formula(2) showing vivid visible color: ##STR1## Wherein Q represents benzene ring with or without substituted radicals and/or condensed ring(s); R.sub.1 and R.sub.2 represent lower alkyl radicals hydroxyalkyl radicals or alkoxyalkyl radicals of the same or different kinds,; R.sub.
    Type: Grant
    Filed: February 6, 1980
    Date of Patent: February 2, 1982
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Masaaki Hayami, Seiko Torikoshi
  • Patent number: 4242513
    Abstract: Chromogenic compounds of normally colorless form are disclosed having the following structural formula: ##STR1## wherein E represents a six-membered aromatic or heterocyclic ring which may have an aromatic condensed ring and both the E ring and the condensed ring may be substituted, A represents an optionally substituted aminophenyl, indolyl, benzoindolyl, julolidinyl or kairolyl radical or the radical represented by B, and B represents a family of heterocyclic radicals. The compounds of this invention are eligible for use in pressure-sensitive and heat sensitive record materials and manifold marking systems.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: December 30, 1980
    Assignee: Appleton Papers Inc.
    Inventors: Troy E. Hoover, Sheldon Farber, William J. Becker
  • Patent number: 4174321
    Abstract: The invention relates to polychromophoric dibenzoxazole compounds which have been found to be effective ultraviolet stabilizers. The invention also relates to ultraviolet degradable organic compositions containing a stabilizing amount of the polychromophoric dibenzoxazole composition to prevent such degradation. These stabilizers are effective in the presence of other additives commonly employed in polymeric compositions including, for example, pigments, colorants, fillers, reinforcing agents and the like. These ultraviolet stabilizers may also be incorporated into the organic compositions in the polymer melt or dissolved in the polymer dope, coated on the exterior of the molded article, film or extruded fiber.
    Type: Grant
    Filed: September 1, 1977
    Date of Patent: November 13, 1979
    Assignee: Eastman Kodak Company
    Inventors: Richard H. S. Wang, Joseph S. Zannucci
  • Patent number: 4174397
    Abstract: Thiazolidine derivatives of the formula I ##STR1## in which the substituents R.sup.1 to R.sup.7 have the meanings as indicated in the following and which have in the free form or in the form of their non toxic acid addition salts valuable pharmaceutical properties, processes for preparing them, pharmaceutical preparations on the basis of these compounds and their use as medicines.
    Type: Grant
    Filed: September 6, 1977
    Date of Patent: November 13, 1979
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Bernd Knabe, Hans-Jochen Lang, Ernold Granzer