Polycyclo Ring System Having The Thiazole Ring As One Of The Cyclos Patents (Class 548/148)
  • Patent number: 9969887
    Abstract: The present disclosure relates to a novel merocyanine-based compound capable of labeling biomolecules by intercalating biomolecules, and to a dye, kit and contrast medium composition for labelling biomolecules comprising the same.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: May 15, 2018
    Assignee: SFC Co., Ltd.
    Inventors: Su-Jin Kim, Do-Min Lee, Jong-Tae Je
  • Patent number: 9631096
    Abstract: Dye compounds of the formula (1) wherein A is a protective agent group that has a characteristic of modifying the singlet-triplet occupancy of the shown cyanine moiety, and M is a reactive crosslinking group or a group that can be converted to a reactive crosslinking group. Methods for synthesizing the dye compounds and applications for their use are also described.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: April 25, 2017
    Assignee: CORNELL UNIVERSITY
    Inventors: Scott C. Blanchard, Roger Altman, J. David Warren, Zhou Zhou
  • Patent number: 9023964
    Abstract: The present invention relates to conjugated polymers. In various embodiments, the present invention provides a conjugated polymer including a repeating unit including a benzene ring conjugated with the polymer backbone, wherein the benzene ring is fused to two 5-membered rings, wherein each fused 5-membered ring includes N and at least one of O and S. In various embodiments, the present invention provides semiconductor devices including the polymer, and methods of making the polymer.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 5, 2015
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Malika Jeffries-EL, Jeremy J. Intermann, Brian C. Tlach
  • Publication number: 20150034887
    Abstract: A novel photochromic compound which develops a color of a neutral tint (double peak characteristic) and has high color optical density, high fading speed and excellent durability. Like a compound represented by the following formula (20), the photochromic compound having a group (methylthio group in the following formula 20) which has a sulfur atom bonded to the 7-position carbon atom is a photochromic compound having high color optical density, high fading speed and excellent durability.
    Type: Application
    Filed: March 11, 2013
    Publication date: February 5, 2015
    Applicant: TOKUYAMA CORPORATION
    Inventors: Shinobu Izumi, Yasutomo Shimizu, Junji Momoda
  • Publication number: 20140319473
    Abstract: A compound represented by Formula 1 below and an organic light-emitting device including the compound are provided: Substituents in Formula 1 are the same as defined in the specification.
    Type: Application
    Filed: September 13, 2013
    Publication date: October 30, 2014
    Applicant: Samsung Display Co., Ltd.
    Inventor: Jung-Sub Lee
  • Patent number: 8859717
    Abstract: Nitrogen-containing fused ring compound having at least one structural unit selected from the group consisting of a structural unit represented by the formula (1-1) and a structural unit represented by the formula (1-2).
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: October 14, 2014
    Assignees: Sumitomo Chemical Company, Limited, Osaka University
    Inventors: Yutaka Ie, Masashi Ueta, Yoshio Aso, Masato Ueda
  • Patent number: 8841410
    Abstract: It is an object of the present invention to provide a nitrogen-containing condensed ring compound, which can be used as an organic n-type semiconductor having an excellent electron transport property and which is also excellent in terms of solubility in an organic solvent. The nitrogen-containing condensed ring compound of the present invention has a structural unit represented by the following formula (1-1) or formula (1-2): wherein Ar1 represents an aromatic ring; one of Y1 and Y2 represents a single bond, and the other represents —C(R11)(R12)— or —C(?X1)—; one of Y3 and Y4 represents a single bond, and) the other represents —C(R21)(R22)— or —C(?X2)—, and one of Y1 to Y4 represents —C(R11)(R12)— or —C(R21)(R22)—; at least one of W1 and W2 represents —N?; and Z1 and Z2 each represent any one of the groups represented by the formula (i) to the formula (ix).
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: September 23, 2014
    Assignees: Sumitomo Chemical Company, Limited, Osaka University
    Inventors: Yoshio Aso, Yutaka Ie, Masashi Ueta, Masato Ueda
  • Patent number: 8703962
    Abstract: The invention relates to compounds of formula I and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: April 22, 2014
    Assignee: Purdue Pharma L.P.
    Inventors: Donald J. Kyle, Laykea Tafesse
  • Patent number: 8697911
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: April 15, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Brian Nicholas Cook, Jennifer A. Kowalski, Xiang Li, Daniel Richard Marshall, Sabine Schlyer, Robert Sibley, Lana Louise Smith-Keenan, Fariba Soleymanzadeh, Ronald John Sorcek, Erick Richard Roush Young, Yunlong Zhang
  • Publication number: 20130324685
    Abstract: It is an object of the present invention to provide a nitrogen-containing condensed ring compound, which can be used as an organic n-type semiconductor having an excellent electron transport property and which is also excellent in terms of solubility in an organic solvent. The nitrogen-containing condensed ring compound of the present invention has a structural unit represented by the following formula (1-1) or formula (1-2): wherein Ar1 represents an aromatic ring; one of Y1 and Y2 represents a single bond, and the other represents —C(R11)(R12)— or —C(?X1)—; one of Y3 and Y4 represents a single bond, and the other represents —C(R21)(R22)— or —C(?X2)—, and one of Y1 to Y4 represents —C(R11)(R12)— or —C(R21)(R22)—; at least one of W1 and W2 represents —N?; and Z1 and Z2 each represent any one of the groups represented by the formula (i) to the formula (ix).
    Type: Application
    Filed: January 30, 2012
    Publication date: December 5, 2013
    Applicants: OSAKA UNIVERSITY, SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yoshio Aso, Yutaka Ie, Masashi Ueta, Masato Ueda
  • Patent number: 8586550
    Abstract: The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: November 19, 2013
    Assignee: Green Cross Corporation
    Inventors: Jinhwa Lee, Jeongmin Kim, Suk Ho Lee, Junwon Lee, Kwang-Seop Song, Eun-Jung Park, Min Ju Kim, Hee Jeong Seo, Sung-Han Lee, Eun Jung Son, Jong Yup Kim, Suk Youn Kang, Younggyu Kong
  • Patent number: 8586325
    Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: November 19, 2013
    Assignee: Biotium, Inc.
    Inventors: Fei Mao, Hui Cen
  • Publication number: 20130041123
    Abstract: Nitrogen-containing fused ring compound having at least one structural unit selected from the group consisting of a structural unit represented by the formula (1-1) and a structural unit represented by the formula (1-2).
    Type: Application
    Filed: March 3, 2011
    Publication date: February 14, 2013
    Applicants: OSAKA UNIVERSITY, SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yutaka Ie, Masashi Ueta, Yoshio Aso, Masato Ueda
  • Publication number: 20130030027
    Abstract: The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl optionally substituted with one or more of halogen, —OH, or —C1-6alkyl; and R is —CN, a 5- or 6-membered heteroaryl, or halogen; and the pharmaceutically acceptable salt forms thereof, in addition to methods of using these compounds.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 31, 2013
    Applicants: The Regents of the University of California, The Trustes of The University of Pennsylvania
    Inventors: Amos B. Smith, III, Zhuqing Liu, Anne-Marie L. Hogan, Doralyn S. Dalisay, Tadeusz F. Molinski
  • Patent number: 8227470
    Abstract: The present invention relates to a method for treating solid cancers including non-small 5 cell lung cancer, pancreatic, bladder, breast and ovarian cancer as well as advanced biliary tract cancers comprising administering at least one antineoplasticagent such as a nucleotide analog, for example gemcitabine, or an antimitotic such as docetaxel, in combination with a tyrosine kinase inhibitor selected from 2-aminoarylthiazoles and 2-aminoaryloxazoles.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: July 24, 2012
    Assignee: AB Science
    Inventors: Alain Moussy, Jean-Pierre Kinet
  • Publication number: 20120168729
    Abstract: An example embodiment relates to an organic semiconductor compound, represented by Chemical Formula 1 herein, which may be polymerized and used in transistors and electronic devices. The organic semiconductor compound includes a base structure of four fused benzene rings with functional groups R1 to R3 connected to a first benzene ring and with functional groups R4 to R6 connected to a second benzene ring. The base structure's third and fourth benzene rings are connected to X1, X2 and X3, X4 respectfully. At least one of X1 and X2 is a sulfur atom. At least one of X3 and X4 is a sulfur atom. The base structure further includes functional groups R7 and R8.
    Type: Application
    Filed: January 12, 2012
    Publication date: July 5, 2012
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jeong-il Park, Bang Lin Lee, Jong Won Chung
  • Publication number: 20120168726
    Abstract: An example embodiment relates to an organic semiconductor compound, represented by Chemical Formula 1 herein, which may be polymerized and used in transistors and electronic devices. The organic semiconductor compound includes a base structure of four fused benzene rings with functional groups R1 to R3 connected to a first benzene ring and with functional groups R4 to R6 connected to a second benzene ring. The base structure's third and fourth benzene rings are connected to X1, X2 and X3, X4 respectfully. At least one of X1 and X2 is a sulfur atom. At least one of X3 and X4 is a sulfur atom. The base structure further includes functional groups R7 and R8.
    Type: Application
    Filed: July 21, 2011
    Publication date: July 5, 2012
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jeong-Il Park, Bang Lin Lee, Jong Won Chung
  • Patent number: 8148539
    Abstract: Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: April 3, 2012
    Assignees: GE Healthcare UK Limited, Carnegie Mellon University
    Inventors: Richard M. West, Nigel Bosworth, Ratnakar B. Mujumdar
  • Patent number: 8101776
    Abstract: The invention relates to a semiconductor device comprising a compound of the formula I and of the formula XXI, wherein the symbols have the meanings defined in the specification, to the novel compounds of the formula I and XXI and to the use of such a compound as an organic semiconductor for the preparation of an electronic device, and further compounds and devices, as well as other embodiments given in the specification.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: January 24, 2012
    Assignee: BASF SE
    Inventors: Ulrich Berens, Frank Bienewald, Hans Jürg Kirner
  • Patent number: 8003801
    Abstract: A highly active synthetic epothilone compound whose activity exceeds that of either epothilone EpoA or EpoB when assayed as a cytotoxic agent against a cancer cell line is disclosed as is a pharmaceutical composition containing the synthetic epothilone.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: August 23, 2011
    Assignee: The Scripps Research Institute
    Inventors: Kyriacos C. Nicolaou, Benjamin Pratt, Stellios Arseniyadis
  • Patent number: 7947506
    Abstract: A hydroxyquinolone compound formulated as a fluorescent dye for protein detection, assay, quantitation, etc. The hydroxyquinolone compound may be modified, for example, by adding or removing sulfate groups, changing hydrocarbon chain lengths, etc. to result in more desirable properties such as enhanced binding to basic proteins, enhanced solubility, etc. The dye has enhanced sensitivity over commercially available protein stains, and may be used to stain proteins in solution, proteins separated on gels, proteins transferred to solid supports, etc. Methods of using the dyes are also disclosed.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: May 24, 2011
    Assignee: Pierce Biotechnology, Inc.
    Inventors: Brian David Wolf, Surbhi Desai, Peter T. Czerney, Frank G. Lehmann, Bernd G. Schweder, Matthias S. Wenzel
  • Patent number: 7923446
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: April 12, 2011
    Assignee: Wyeth LLC
    Inventors: Jason Shaoyun Xiang, Steve Yikkai Tam, Yonghan Hu, Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini, Thomas Saltmarsh Rush, III, Elisabeth Ann Morris, Katy Evangelia Georgiadis
  • Publication number: 20110006287
    Abstract: A copolymer comprising at least one donor monomer and at least one acceptor monomer is described. The polymer may optionally further comprise, consist or consist essentially of at least one additional comonomer. Various donor monomers, acceptor monomers and additional comonomers are also described. The polymer is useful in the manufacture of microelectronic devices such as optoelectronic devices.
    Type: Application
    Filed: March 18, 2010
    Publication date: January 13, 2011
    Inventors: Wei You, Shengqiang Xiao
  • Publication number: 20100298291
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
    Type: Application
    Filed: July 30, 2010
    Publication date: November 25, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Marlon D. Cowart, Yi-Yin Ku, Sou-Jen Chang, Dilinie P. Fernando, Timothy A. Grieme, Robert J. Altenbach
  • Patent number: 7750163
    Abstract: Disclosed are cyanine dyes that are useful for labeling and detecting biological and other materials. The dyes are of formula (I) in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: July 6, 2010
    Assignees: GE Healthcare U.K. Limited, Carnegie Mellon University
    Inventors: Richard M. West, Nigel Bosworth, Ratnakar B. Mujumdar
  • Patent number: 7749994
    Abstract: The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2, R3 and m are defined herein.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: July 6, 2010
    Assignees: Genentech, Inc., Hoffman-LaRoche, Inc. (US Only), F. Hoffman-LaRoche, AG (EX-US)
    Inventors: Thomas E. Rawson, Brian Safina, Jennafer Dotson, Aihe Zhou, Ignacio Aliagas-Martin, Jason Halladay, Jun Liang, Matthias Rueth, Bing-Yan Zhu, Frederick Brookfield, Michael Prime, Birong Zhang, Jun M. Li
  • Patent number: 7700765
    Abstract: There is provided an oligopeptide compound comprising: (a) at least one nitrogen-containing basic group attached to at least one end of the oligopeptide; and (b) two or more heterocyclic monomers, at least one of which is substituted in the heterocyclic part by a branched, cyclic or part cyclic C3-5 alkyl group, or a pharmaceutically acceptable salt or solvate thereof; which compound, salt or solvate binds to the minor groove of DNA.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: April 20, 2010
    Assignee: University of Strathclyde
    Inventors: Abedawn Khalaf, Roger Waigh, Colin Suckling
  • Patent number: 7655676
    Abstract: Use of the compound of formula (I) and the pharmaceutically acceptable addition salts thereof for the manufacture of a medicament for topical treatment or 5 prevention of acne formula (I) wherein: R represents methoxymethyl, R1 represents methyl, Rz represents methyl, Y represents the group formula (II) The compound of formula (I) and the pharmaceutically acid addition salts thereof show selective activity against propionibacterium acne and are suitable for use in a method of treatment or prevention of acne.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: February 2, 2010
    Assignee: Naicons S.C.A.R.L.
    Inventors: Adriano Malabarba, Marco Cavaleri, Giorgio Mosconi, Daniela Jabes, Gabriela Romano
  • Patent number: 7628938
    Abstract: The present invention provides a photochromic compound that is colored when irradiated with visible light and quickly faded when set in a dark place. The photochromic compound according to the present invention is expressed by the following general formula (I): where each of A1, A2 and A3 is a five-member rings forming a 6?-electron system, the three rings being identical, partially identical or totally different from each other, and each ring may have a substituent; B1 and B2 are functional groups, each having an atomic number of five or larger, including a ring compound, and bonded to the 2-carbon of each of A2 and A3, respectively; and R1, R2 and R3 are substituents identical to or different from each other. This compound is highly colorable and durable even when it is dispersed into plastic macromolecular materials. Therefore, it is suitable as a dye material for sunglasses or similar products.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: December 8, 2009
    Assignee: National University Corporation Nara Institute of Science and Technology
    Inventors: Tsuyoshi Kawai, Takuya Nakajima, Shigekazu Kawai
  • Patent number: 7595398
    Abstract: Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: September 29, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ali Dehghani Mohammad Abadi, Ronald Conrad Griffith, Martin Robert Leivers, Irina Slobodov, Roopa Rai
  • Patent number: 7563901
    Abstract: The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: July 21, 2009
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Toshiro Sasaki, Takashi Ando, Yasuo Yamamoto, Takahiro Imai, Dai Kubota, Katsuhiko Noguchi, Nobuyuki Hori, Eiki Shitara, Kunio Atsumi, Shohei Yasuda
  • Publication number: 20080293747
    Abstract: A highly active synthetic epothilone compound whose activity exceeds that of either epothilone EpoA or EpoB when assayed as a cytotoxic agent against a cancer cell line is disclosed as is a pharmaceutical composition containing the synthetic epothilone.
    Type: Application
    Filed: November 9, 2006
    Publication date: November 27, 2008
    Inventors: Kyriacos C. Nicolaou, Benjamin Pratt, Stellios Arseniyadis
  • Patent number: 7419993
    Abstract: The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B.
    Type: Grant
    Filed: February 9, 2005
    Date of Patent: September 2, 2008
    Assignee: Helmholtz Center of Infection Research GmbH
    Inventors: Gerhard Hoefle, Nicole Glaser
  • Patent number: 7407977
    Abstract: There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: August 5, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Jianping Cai, Adrian Wai-Hing, Fariborz Firooznia, Kevin Richard Guertin, Lida Qi
  • Publication number: 20080006797
    Abstract: The present invention provides a photochromic compound that is colored when irradiated with visible light and quickly faded when set in a dark place. The photochromic compound according to the present invention is expressed by the following general formula (I): where each of A1, A2 and A3 is a five-member rings forming a 6?-electron system, the three rings being identical, partially identical or totally different from each other, and each ring may have a substituent; B1 and B2 are functional groups, each having an atomic number of five or larger, including a ring compound, and bonded to the 2-carbon of each of A2 and A3, respectively; and R1, R2 and R3 are substituents identical to or different from each other. This compound is highly colorable and durable even when it is dispersed into plastic macromolecular materials. Therefore, it is suitable as a dye material for sunglasses or similar products.
    Type: Application
    Filed: March 21, 2007
    Publication date: January 10, 2008
    Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Tsuyoshi Kawai, Takuya Nakajima, Shigekazu Kawai
  • Patent number: 7317107
    Abstract: Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: January 8, 2008
    Assignee: Astellas Pharma Inc.
    Inventors: Kiyoshi Tsuji, Tadashi Terasaka, Nobukiyo Konishi, Takeshi Kato, Katsuya Nakamura
  • Patent number: 7309715
    Abstract: A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: December 18, 2007
    Assignee: Sterix Limited
    Inventors: Nigel Vicker, Su Xiangdong, Dharshini Ganeshapillai, Atul Purohit, Michael John Reed, Barry Victor Lloyd Potter
  • Patent number: 7276611
    Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are useful as intermediates in the preparation of ?-lactamase inhibitors.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: October 2, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
  • Patent number: 7270800
    Abstract: This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: September 18, 2007
    Assignee: University of Pittsburgh
    Inventors: William E. Klunk, Chester A. Mathis, Jr., Yanming Wang
  • Patent number: 7268135
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: September 11, 2007
    Assignee: Wyeth
    Inventors: Jason Shaoyun Xiang, Steve Yikkai Tam, Yonghan Hu, Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini, Thomas Saltmarsh Rush, III
  • Patent number: 7196200
    Abstract: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: March 27, 2007
    Assignee: Abbott Laboratories
    Inventors: David D. Anderson, Bruce A. Beutel, Curt S. Cooper, Yu-Gui Gu, Mira M. Hinman, Douglas M. Kalvin, Robert F. Keyes, Xenia B. Searle, Rolf Wagner
  • Patent number: 7192657
    Abstract: Compounds, compositions, organic electronic devices, and methods for preparing organic electronic devices are described. The compounds of the invention contain at least two carbon-carbon triple bonds and a heteroaromatic ring having at least one —C?N— unit. The compounds can be used as electron transport agents in organic electronic devices such as organic electroluminescent devices.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: March 20, 2007
    Assignee: 3M Innovative Properties Company
    Inventors: Ralph R. Roberts, Yingbo Li, Sergey A. Lamansky
  • Patent number: 7166715
    Abstract: The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labelled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labelled polynucleotides.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: January 23, 2007
    Assignee: Applera Corporation
    Inventors: Linda G. Lee, Ronald J. Graham, Khairuzzaman B. Mullah, Francis T. Haxo
  • Patent number: 7132439
    Abstract: The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: November 7, 2006
    Assignee: Icagen, Inc.
    Inventors: Xiaodong Wang, Alan B. Fulp, Albert M. van Rhee, Kerry L. Spear
  • Patent number: 7041825
    Abstract: The present invention relates to 1,3,4-thiadiazole reaction products useful as accelerators and/or curing agents for halogenated polymers in rubber vulcanization processes, and to halogenated polymer compositions containing the thiadiazole derivatives, as well as a method of preparing the same. The additive is the reaction product of a 1,3,4-thiadiazole compound and a dithiocarbamic acid or an amine, or an isomer thereof.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: May 9, 2006
    Assignee: R.T. Vanderbilt Company, Inc.
    Inventors: Thomas J. Karol, Francis S. Cheng, Ronald J. Tepper
  • Patent number: 6800380
    Abstract: An organometallic luminescent material comprising the compound of formula (I) of the present invention can emit pure blue light and have high thermal stability: wherein, M1 is a monovalent or tetravalent metal selected from the group consisting of Li, Na, K, Zr, Si, Ti, Sn, Cs, Fr, Rb, Hf, Pr, Pa, Ge, Pb, Tm and Md; R is hydrogen or C1-10 alkyl; B is O, S, Se or Te; D is O or S; and n is an integer ranging from 1 to 4.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: October 5, 2004
    Assignee: Nessdisplay Co., Ltd.
    Inventors: Youngkyoo Kim, Jae-Gyoung Lee
  • Patent number: 6756497
    Abstract: Benzoic acid derivatives useful as intermediates for the preparation of drugs and agricultural chemicals, particularly compounds having herbicidal activity; and easy and economical processes for the preparation of the same. The processes are specifically those represented by reaction formula for the preparation of compounds represented by general formulae (1) and (6).
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: June 29, 2004
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Yuuki Nakagawa, Masao Yamaguchi, Hiroyuki Adachi, Hiroyuki Yamanaka, Tomio Yagihara, Masami Hatano
  • Patent number: 6750024
    Abstract: The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labelled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labelled polynucleotides.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: June 15, 2004
    Assignee: Applera Corporation
    Inventors: Linda G. Lee, Ronald J. Graham, Khairuzzaman B. Mullah, Francis T. Haxo
  • Publication number: 20040063820
    Abstract: Additives including dithiocarbamyl derivatives of 2,5-dimercapto-1,3,4-thiadiazole (DMTD) useful as curing agents and accelerators. Curable polymer compositions including at least one halogenated polymer and at least one additive including the dithiocarbamyl DMTD derivatives. A method is also disclosed for preparing a cured polymer by admixing at least one halogenated polymer with at least one additive including the dithiocarbamyl DMTD derivatives and subsequently curing the composition.
    Type: Application
    Filed: July 11, 2003
    Publication date: April 1, 2004
    Applicant: R.T. Vanderbilt Company, Inc.
    Inventors: Thomas J. Karol, Francis S. Cheng
  • Patent number: 6635696
    Abstract: Additives including dithiocarbamyl derivatives of 2,5-dimercapto-1,3,4-thiadiazole (DMTD) useful as curing agents and accelerators. Curable polymer compositions including at least one halogenated polymer and at least one additive including the dithiocarbamyl DMTD derivatives. A method is also disclosed for preparing a cured polymer by admixing at least one halogenated polymer with at least one additive including the dithiocarbamyl DMTD derivatives and subsequently curing the composition.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: October 21, 2003
    Assignee: R.T. Vanderbilt Company, Inc.
    Inventors: Thomas J. Karol, Francis S. Cheng