Abstract: This invention relates to novel derivatives of imino diacetic acid of the formula: ##STR1## wherein R.sup.1 is selected from the group consisting of: ##STR2## wherein X is halo (chloro, bromo or iodo) and R.sup.2 is lower alkyl of from 1-5 carbon atoms. It also relates to a novel diagnostic kit for hepatobiliary imaging comprising ingredients employed in the intravenous injection of a complex of technetium 99m, and an imino diacetic acid of the above formula. It also relates to a process for preparing said compounds by reaction of nitrilotriacetic acid anhydride and an amine of the formula R.sup.1 NH.sub.2 wherein R.sup.1 is as defined hereinabove.
Abstract: Novel N-substituted imido-dicarboxylic acid diaryl ester compounds of the general formula ##STR1## in which R.sup.1 represents an optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic, heterocyclic radical andR.sup.2 and R.sup.3 can be identical or different and represent an optionally substituted aryl radical, and a process for their preparation characterized in that a carbamic acid aryl ester of the general formulaR.sup.1 --NH--CO--OR.sup.2 (II)in which R.sup.1 and R.sup.2 have the abovementioned meanings, is reacted with a carbonic acid aryl ester halide of the general formulaX--CO--OR.sup.3 (III)in whichR.sup.3 has the abovementioned meaning andX represents a halogen atom, optionally in the presence of a diluent, optionally at a temperature between 100.degree. and 300.degree. C.The new compounds (I) can be used as intermediate products for the preparation of known herbicidal active compounds from the 1,3,5-triazine,2,4-(1H,3H)-dione series.
Abstract: A process for the preparation of substituted urea derivatives, and compositions and concentrates for the same purpose are disclosed. According to the process the substituted urea derivatives of formula (I) ##STR1## wherein R is hydrogen, alkyl, aryl, cycloalkyl or aralkyl, R.sup.1 and R.sup.2 are hydrogen, alkyl, alkenyl, alkinyl, alkoxy, oxyalkyl, cycloalkyl, aralkyl, alkoxycarbonylalkyl, aryl or heteroaryl, or R.sup.1 and R.sup.
Type:
Grant
Filed:
December 28, 1981
Date of Patent:
March 6, 1984
Assignee:
Chinoin Gyogyszer es Vesgyeszeti Termekek Gyara R. T.
Inventors:
Gyorgy Lugosi, Antal Simay, Janos Bodnar, Laszlo Simandi, Eva Somfai
Abstract: Novel compounds of the formula ##STR1## wherein X and Y are the same or different and are hydrogen, fluora, chloro, bromo, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, nitro, cyano, amino, trifluoromethyl, ##STR2## wherein R.sub.1 is alkyl of one to six carbon atoms, inclusive, ##STR3## wherein R.sub.2 and R.sub.3 are the same or different and are hydrogen or alkyl of one to three carbon atoms inclusive, or CO.sub.2 Q where Q is alkyl of one to six carbon atoms, inclusive, hydrogen or a physiologically acceptable metal or amine cation; and R is hydrogen, alkyl of one to eight carbon atoms, inclusive, --CH.sub.2).sub.m phenyl wherein m is 0, 1 or 2 or (CH.sub.2).sub.n NR.sub.4 R.sub.5 wherein n is 1 or 2, and R.sub.4 and R.sub.
Abstract: A process for the preparation of N,O-disubstituted urethanes. Primary amines and alcohols are reacted with organic compounds having carbonyl groups at 120.degree. to 350.degree. C. Suitable carbonyl-containing compounds include N-unsubstituted urethanes. N-mono-substituted, N,N'-disubstituted ureas, or polyureas may be used in combination with the N-unsubstituted urethane. The product urethanes are particularly suitable for the preparation of isocyanates.
Type:
Grant
Filed:
October 15, 1980
Date of Patent:
June 14, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Peter Heitkamper, Klaus Konig, Rudolf Fauss, Kurt Findeisen
Abstract: The invention relates to certain urea derivatives of the formula R.sub.1 CH.sub.2 S(CH.sub.2).sub.2 NHCONHR.sub.2 where R.sub.1 are certain furanyls, imidazoles and thiazolyls and R.sub.2 are certain imidazoles and thiazolyls. These compounds are H-2 histamine receptor inhibitors and therefore useful in the treatment of ulcers.
Type:
Grant
Filed:
August 25, 1981
Date of Patent:
May 31, 1983
Assignee:
G. D. Searle & Co.
Inventors:
Richard E. L. Henderson, Barnett S. Pitzele
Abstract: The invention discloses novel herbicidally active and plant growth-regulating benzthiazolylurea derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 -alkylnyl or C.sub.3 -C.sub.6 cycloalkyl; R.sub.2 has the same meaning as R.sub.1 or is C.sub.1 -C.sub.6 alkoxy; R.sub.1 and R.sub.2, together with the nitrogen atom to which they are attached, also form a 5- to 6-membered heterocyclic ring which can be substituted by C.sub.1 -C.sub.3 alkyl; R.sub.3 is hydrogen, C.sub.1 -C.sub.6 alkyl, an alkali metal cation or an alkaline earth metal cation or a C.sub.1 -C.sub.4 alkylammonium radical, the alkyl moieties of which can be substituted by OH, NH.sub.2, CN or C.sub.1 -C.sub.4 alkoxy; R.sub.5 to R.sub.9 are preferably hydrogen or C.sub.1 -C.sub.4 alkyl, but can also have one of the other meanings defined more closely in the specification; X.sub.1 and X.sub.2, each independently of the other, is a C.sub.1 -C.sub.8 alkoxy or C.sub.1 -C.sub.
Abstract: 2-Amino-6-nitrobenzothiazole is obtained with a high selectivity if, instead of unprotected 2-aminobenzothiazole, acylation products thereof are nitrated and the acyl groups are then split off. 2-Amino-6-nitrobenzothiazole is an important intermediate product for the preparation of valuable azo dyestuffs.
Type:
Grant
Filed:
April 23, 1981
Date of Patent:
January 18, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Walter Horstmann, Richard Sommer, Hans Trautwein, Gerhard Wolfrum
Abstract: A method for preparing image-forming color couplers containing a thioether group at the coupling active position is disclosed which comprises reacting a compound of the formula A-H where A is a cyan, magenta or yellow coupler residue in which a hydrogen atom at the coupling off position is removed with a disulfide of the formula (IIa) or (IIb): ##STR1## where R is a straight chain, branched chain or cyclic alkyl group, a cyclic alkenyl group, or an aralkyl group or a ##STR2## group, B is Y, -D-Y or ##STR3## where D is an oxygen atom or >N--R.sub.4, R.sub.4 is a hydrogen atom, an alkyl group or an aryl group, Y is a straight chain, branched chain or cyclic alkyl group, a straight chain, branched chain or cyclic alkenyl group, an aralkyl group, an aryl group, or a heterocyclic group, Q is a non-metallic atomic group necessary for completing a 5- or 6-membered nitrogen-containing heterocyclic group and R.sub.1, R.sub.2 and R.sub.
Abstract: Dyestuffs of the formula ##STR1## wherein R.sub.1 represents hydrogen, alkyl or aralkyl,R.sub.2 represents R.sub.1 or aryl,A represents C.sub.2 -C.sub.6 -alkylene,X represents R.sub.2 or acyl,n represents 1-7,m represents 1 or 2 andthe rings B and D can contain customary radicals,with the proviso that n is at least 2 if X represents acyl,give, when mixed with emulsifiers, dyestuff preparations which are in the liquid or dissolved form under dyeing conditions. The use of additional dispersing agents, protective colloids, levelling agents and carriers when dyeing polyester fibres thereby becomes superfluous.
Type:
Grant
Filed:
August 13, 1979
Date of Patent:
September 29, 1981
Assignee:
Bayer Aktiengesellschaft
Inventors:
Winfried Kruckenberg, Karl H. Schundehutte
Abstract: 2-(dimethylcarbamoylimino)-benzthiazoline-3-id-salts of the formula ##STR1## in which B.sup.(+) is a univalent metal equivalent. The compounds have herbicidal activity and may be used in herbicidal compositions.
Abstract: Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a heterocyclic ring which may be substituted with one or more loweralkyl groups. The urea is also substituted with loweralkyl and a lower-alkylamino loweralkyl group. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
Abstract: New compounds which are herbicide antagonists that are useful for protection of plants from various herbicides are members of the group having the general structural formulas: ##STR1## in which R is hydrogen or C.sub.1 to C.sub.4 alkyl, alkenyl or alkynyl, branched or straight chain, R.sup.1 is C.sub.1 to C.sub.3 alkyl, alkenyl or alkynyl, branched or straight chain, with the total number of carbon atoms in R and R.sup.1 being less than six, preferably less than four, on compounds with both R and R.sup.1 substituents. The novel plant protection agents may be applied both to seeds and to the soil.
Abstract: Crystalline monohydrate (Form III) and anhydrate (Form IV) of N-2-(6-methoxy)benzothiazolyl-N'-phenylurea (frentizole) are stable, have a greater bulk density, are less electrostatic and more freely flowing than previous crystalline forms.
Type:
Grant
Filed:
February 9, 1979
Date of Patent:
September 16, 1980
Assignee:
Eli Lilly and Company
Inventors:
Lewis C. Lappas, Leslie J. Lorenz, James H. Wikel
Abstract: 2-(Dimethylcarbamoylimino)-benzthiazoline-3-carboxylic acid ester of the formula ##STR1## in which R is an aliphatic hydrocarbon, a substituted aliphatic hydrocarbon, an aromatic hydrocarbon or a substituted aromatic hydrocarbon and X is oxygen or sulfur.The compounds have an excellent selectivity action in regard to agricultural plants and also possess a superior herbicidal activity against mono- and di-cotyl weeds.