Abstract: This invention is directed to compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.6 is hydrogen or lower alkyl;each R.sub.1 is hydrogen, lower alkyl, halogen, nitro, trihaloalkyl, lower alkoxy, formyl, lower alkanoyl, loweralkylamino or diloweralkylamino ##STR2## X is O, S or NR.sub.5 ; R.sub.2 is OR.sub.7 or NR.sub.7 R.sub.8 ;each R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl;R.sub.5 R.sub.7 and R.sub.8 are independently hydrogen or lower alkyl;n is 0-3 andm is 0-6.These compounds are useful for treating glaucoma or assessing corneal function in mammals.

Abstract: This invention relates to a process for preparing useful thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)thioxomethyl]hydrazono]ethyl]-1.alpha. ,4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha.,7a.alpha.-4.alpha.,7.alpha.-meth ano-2H-inden-2-ones.

Abstract: Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful an anti-asthmatic, antiallergic, anti-inflammatory, and cytoprotective agents.

Abstract: Derivatives of 4-((aryloxy)phenoxy)alkenols, their preparation and use as active herbicides for the postemergent control of grassy weeds and especially the control of said weeds in the presence of corn plants are disclosed.

Abstract: Substituted benzyl ethers, benzyl thioethers, and benzylamines of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and represent hydrogen, alkyl, alkenyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, sulphonylalkyl, halogenoalkoxy, halogenoalkylthio, aralkoxy, aralkylthio, halogen, nitro, cyano or hydroxyl, or represent a group of the formula ##STR2## wherein R.sup.4 and R.sup.5 are identical or different and represent hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl or acyl,R.sup.3 represents a group of the formula ##STR3## in which R.sup.6 represents hydrogen, alkyl or acyl,R.sup.7 represents hydrogen or alkyl andn represents a number from 3 to 10,B represents --CH.sub.2 --X-- or --X--CH.sub.2 --,wherein X represents O, S or NR.sup.7,and wherein R.sup.7 has the abovementioned meaning and the group ##STR4## represents a benzo-fused heterocyclic system, A in the heterocyclic radical being 3-, 4- or 5-membered and containing nitrogen, oxygen and/or sulphur as hetero-atoms.

Abstract: A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-amino-2-benzothiazolesulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-amino-2-benzothiazolesulfonamide compound.

Abstract: A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-hydroxyethoxy-2-benzothiazolesulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-hydroxyethoxy-2-benzothiazolesulfonamide compound.

Abstract: A composition useful for incorporation into polymer compositions employed for food packaging or the like comprising a bis- or tris-methine compound having the structural formula ##STR1## wherein A is selected from the radicals ##STR2## wherein R' and R" are each selected from chlorine, bromine, fluorine, alkyl, alkoxy, aryl, aryloxy and arylthio;each n is independently 0, 1, 2;R.sub.1 is selected from a large variety of radicals such as cycloalkyl, phenyl, and straight or branched alkyl which may be substituted;R.sub.2 is alkylene or the like;R.sub.3, R.sub.4, and R.sub.5 are each selected from hydrogen and alkyl; andP and Q and P.sup.1 and Q.sup.1 are selected from cyano, carbalkoxy, carbaryloxy, carbaralkyloxy, or the like.The invention compositions are especially useful in combination with molding or fiber-grade condensation polymer; most preferably such polymer having copolymerized therein a total of from 1.

Abstract: Novel HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed: ##STR1##

Abstract: This invention relates to herbicidally active substituted benzoxazolone (or benzthiazolone) compounds and to the use of such compounds to control the growth of noxious plants, i.e., weeds.

Abstract: An improved work-up of aqueous mother liquors which originate from the oxidative preparation of benzothiazolylsulphenamides and which contain unreacted amine or a low-boiling alcohol employed as solubilizer, or both, the work-up being carried out in such a fashion that the mother liquor is saturated by additives until two phases form, the phases are separated from one another, the aqueous phase is extracted with further alcohol or amine, amine, alcohol and the extracted components are isolated from the combined organic phases, and amine or alcohol dissolved in the aqueous phase is removed therefrom by distillation.

Abstract: Novel substituted phenoxyalkanecarboxylic acid esters of the formula ##STR1## in which R.sup.1 and R.sup.2, independently of one another, are a hydrogen atom, a halogen atom, a lower alkyl group or a nitro group, orR.sup.1 and R.sup.2, together with the benzene ring to which they are bonded, are a naphthalene ring,R.sup.3 and R.sup.4, independently of one another, are a hydrogen atom or a methyl group,n is 1 or 2,m is 0 or 1,X is an oxygen atom, a sulfur atom, a sulfonyl group or a group of the formula ##STR2## in which R.sup.6 is a lower alkyl group, R.sup.5 is a hydrogen atom or a halogen atom, andY is an oxygen atom or a sulfur atom, and the use of the new compounds as herbicides.

Abstract: There are disclosed compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, lower alkyl, aryl or halo, or R.sup.1 and R.sup.2 taken together represent --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --O--, --NH--, ##STR2## where the dotted lines represent optional double bonds; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each, independently, hydrogen, lower alkyl, aryl or halo;R.sup.7 is 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl, 3-pyridazinyl or phenyl or any of the foregoing R.sup.7 moieties substituted by lower alkyl, trifluoromethyl, cyano, nitro or halo, with the proviso that when R.sup.1 and R.sup.2 taken together represent ##STR3## then R.sup.7 is other than 2-pyridinyl, 2-pyrimidinyl or substituted pyrimidin-2-yl;Z is --(CH.sub.2).sub.

Abstract: Derivatives of 4-((aryloxy)phenoxy)alkenols, their preparation and use as active herbicides for the postemergent control of grassy weeds and especially the control of said weeds in the presence of corn plants are disclosed.

Abstract: Novel aryloxyphenoxyalkanoates, alkenoates, R-enantiomers and derivatives thereof possess herbicidal activity selectively in the presence of broadleaf crops with preemergent or postemergent applications.

Abstract: Compounds of the general formula: ##STR1## wherein Ar is naphthyl, biphenylyl, phenyl or substituted phenyl; n is 0, 1 or 2; and Het is a heterocyclic group which may optionally be substituted or fused to a phenyl, substituted phenyl or further heterocyclic ring; and their pharmaceutically acceptable salts are antifungal agents useful in combatting fungal infections in animals, including humans.

Abstract: Novel substituted phenoxyalkanecarboxylic acid esters of the formula ##STR1## in which R.sup.1 and R.sup.2, independently of one another, are a hydrogen atom, a halogen atom, a lower alkyl group or a nitro group, orR.sup.1 and R.sup.2, together with the benzene ring to which they are bonded, are a naphthalene ring,R.sup.3 and R.sup.4, independently of one another, are a hydrogen atom or a methyl group,n is 1 or 2,m is 0 or 1,X is an oxygen atom, a sulfur atom, a sulfonyl group or a group of the formula ##STR2## in which R.sup.6 is a lower alkyl group,R.sup.5 is a hydrogen atom or a halogen atom, andY is an oxygen atom or a sulfur atom,and the use of the new compounds as herbicides.

Abstract: A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H.sub.2 -antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.

Abstract: 3-Alkoxy-4-substituted phenoxy alkanoic acid esters, derivatives thereof, and the use thereof for the control of weeds.

Abstract: 3-Amino-4-substituted phenoxy alkanoic (alkenoic) acid esters, derivatives thereof, and the use thereof for the control of weeds.

Abstract: Novel ethers of hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Abstract: Novel carbonates of 6(or 5)-hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Abstract: 3-Alkylthio (arylthio)-4-substituted phenoxy alkanoic acid esters, derivatives thereof, and the use thereof for the control of weeds.

Abstract: 3-Alkylsulfonyloxy-4-substituted phenoxy alkanoic acid esters and the use thereof as intermediates for and as herbicides.

Abstract: Novel carbamates of 6(or 5)-hydroxy-2- benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Abstract: Novel sulfamates of 6(or 5)-hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Abstract: Novel sulfonates of 6(or 5)-hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Abstract: Substituted phenoxyhydroxyketones, intermediates therefor, synthesis thereof, and the use of said compounds for the control of weeds.

Abstract: N-alkyl (aryl) carbamates and thiocarbamates of 3-hydroxy-4-substituted phenoxy alkanoic acid esters which are useful for the control of weeds.

Abstract: Novel carboxylic acid esters of 5-hydroxy-2-benzothiazolesulfonamide are shown to be useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions including drops and inserts are also disclosed, as well as methods for preparing the novel compounds.

Abstract: Novel carboxylic acid esters of 6-hydroxy-2-benzothiazolesulfonamide are shown to be useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions including drops and inserts are also disclosed, as well as methods for preparing the novel compounds.

Abstract: N-substituted benzothiazole-2-sulfonamide compounds represented by the general formula: ##STR1## wherein R is selected from the group consisting of benzothiazolyl or substituted benzothiazolyl represented by the general formula: ##STR2## wherein X is selected from the group consisting of halogen, lower alkyl, lower alkoxy, acetamido or nitro;R' is selected from the group consisting of hydrogen, alkyl, cycloalkyl, benzyl, phenyl, naphthyl, R"--S--, or substituted aryl represented by the general formula: ##STR3## wherein Y is selected from the group consisting of halogen, lower alkyl, or nitro, or mixtures thereof; andR" being selected from the group consisting of alkyl, cycloalkyl, benzyl, phenyl, naphthyl, trichloromethyl or substituted aryl represented by the general formula: ##STR4## wherein Z is selected from the group consisting of halogen, lower alkyl, nitro or carboxy.Methods of making and using the inventive compounds, including their use as scorch retardants.

Abstract: Process for the purification of mercaptobenzothiazole in which the crude product resulting from the reaction of aniline, sulfur and carbon disulfide according to the known process is treated with aniline.

Abstract: Azole and azoline disulfides useful as corrosion inhibitors and antiwear agents are prepared by the halogen-induced coupling of a thiol reactant e.g., hydrocarbyl mercaptans, with a metal azole thiolate, e.g. the potassium salt of 3,5-bis-mercapto 1,2,4-thiadiazole or 2,5-bis-mercapto 1,3,4 thiadiazole in a 2-phase reaction medium comprising a mixture of a hydrocarbon and water.

Abstract: There is disclosed a novel class of vulcanization accelerators, specifically compounds such as 2-(isopropylsulfinyl)-benzothiazole.

Abstract: 4-Nitro-2-trichloromethylphenyl disulfides, their manufacture, agents containing these compounds as active ingredients for use on microorganisms, and the use of these compounds for protecting substrates against microorganisms.

Abstract: Beta-alkyl (or aryl) beta-hydroxyethyl heterocyclic sulfoxides are prepared by reacting an olefin and 2-mercaptobenzothiazole with oxygen in the presence of a dye sensitizer using visible light as an energy source at a temperature from -10.degree. to 70.degree. C.

Abstract: Azole and azoline disulfides useful as corrosion inhibitors and antiwear agents are prepared by the halogen-induced coupling of a thiol reactant e.g., hydrocarbyl mercaptans, with a metal azole thiolate, e.g. the potassium salt of 3,5-bis-mercapto 1,2,4-thiadiazole or 2,5-bis-mercapto 1,3,4-thiadiazole in a 2-phase reaction medium comprising a mixture of a hydrocarbon and water.

Abstract: A disulfide derivative, having S--S exchange reactivity, of the formulaR.sub.1 --S--S--R.sub.2 --CO--R.sub.3).sub.n R.sub.4 [I]wherein R.sub.1 is 2-benzothiazolyl or 2-pyridyl-N-oxide, R.sub.2 is alkylene having optionally free or protected functional groups, R.sub.3 is the carboxyl residue of an amino acid or lower polypeptide, R.sub.4 is carboxyl or a reactive derivative thereof or protected carboxyl or imidate, and n is 0 or 1.

Abstract: Novel biocidal compounds have the general structural formula ##STR1## wherein n is 0, 1, or 2 and R is alkyl, alkylcarbalkoxy, cyclohexyl, halophenyl, benzyl, N,N-di-lower alkyl carbamoyl, hexamethyleneimino carbonyl, pyrimidyl, lower alkyl substituted pyrimidyl, benzimidazole, lower alkyl substituted imidazole, benzothiazole and O,O-di-lower alkyl thiophosphoryl; with the proviso that when n is 0, R is other than alkyl or cyclohexyl.

Abstract: A disulfide compound of a carrier, having S--S exchange reactivity, of the formulaR--S--S--X.sub.1 --X.sub.2 --A [I]wherein R is 2-benzothiazolyl, X.sub.1 is a spacer group directly bound to the --S--S-- and comprises a plurality of carbon atoms in a straight or branched chain, X.sub.2 is an imide or amide bonding group, and A is an insoluble carrier selected from the group consisting of beads gel agarose residue, gamma-aminopropylated nylon beads residue and a residual group of partially reduced polyacrylonitrile porous granules or fibers.