The Chalcogen, X, Is In A -c(=x)- Group Patents (Class 548/170)
  • Publication number: 20140357864
    Abstract: The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament.
    Type: Application
    Filed: December 6, 2012
    Publication date: December 4, 2014
    Inventors: Ben De Lange, Dennis Heemskerk, Karin Henderika Maria Bessembinder
  • Publication number: 20140343292
    Abstract: The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament.
    Type: Application
    Filed: December 6, 2012
    Publication date: November 20, 2014
    Inventors: Ben De Lange, Dennis Heemskerk, Karin Henderika Maria Bessembinder
  • Publication number: 20140329989
    Abstract: The present invention relates to the preparation of compounds, in particular to the preparation of compounds of formula (I), which may be used with a compound of formula (VI), or a salt thereof as intermediates for the preparation of antifungal agents, preferably micafungin (MICA) or a salt thereof.
    Type: Application
    Filed: September 7, 2012
    Publication date: November 6, 2014
    Applicant: SANDOZ AG
    Inventors: Roland Barth, Kerstin Knepper, Hubert Sturm
  • Patent number: 8865623
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: October 21, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20140199239
    Abstract: The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided.
    Type: Application
    Filed: May 16, 2011
    Publication date: July 17, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Carolyn Ruth Bertozzi, Andreas Stahl, Amy Helene Henkin, Elena A. Dubikovskaya, Allison Cohen
  • Patent number: 8637496
    Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: January 28, 2014
    Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique
    Inventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Hélène Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
  • Publication number: 20130231333
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: September 15, 2011
    Publication date: September 5, 2013
    Applicant: ARAGON PHARMACEUTICALS, INC.
    Inventors: Nicholas D. Smith, Mehmet Kahraman, Steven P. Govek, Johnny Y. Nagasawa, Andiliy G. Lai, Jackaline D. Julien, Mark R. Herbert, Celine Bonnefous, Karensa L. Douglas
  • Publication number: 20130040999
    Abstract: The present invention provides novel compounds of Chemical Formula I, a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, a preparation thereof and a composition for the alleviation, prevention or treatment of osteoporosis, comprising thereof in an effective amount, and a method for alleviating, preventing or treating osteoporosis.
    Type: Application
    Filed: June 14, 2012
    Publication date: February 14, 2013
    Applicant: Ewha University-Industry Collaboration Foundation
    Inventors: Hea-Young PARKCHOO, Kyung-Eun Doh, Mijung Yim, Jung-Min Lee
  • Patent number: 8349994
    Abstract: Disclosed is an electrode electrolyte for solid polymer fuel cells, which uses a polymer electrolyte containing a polyarylene copolymer containing a nitrogen-containing aromatic ring having a substituent represented by —SO3H, —(O(CH2)hSO3H or —O(CF2)hSO3H (wherein h represents an integer of 1-12). By having such a constitution, the electrode electrolyte for solid polymer fuel cells can be produced at a low cost, while being excellent in proton conductivity, dimensional stability, hydrothermal resistance and mechanical strength. In addition, this electrode electrolyte for solid polymer fuel cells enables to recover a catalyst metal.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: January 8, 2013
    Assignees: JSR Corporation, Honda Motor Co., Ltd.
    Inventors: Toshiaki Kadota, Yoshitaka Yamakawa, Fusao Nakagawa, Nagayuki Kanaoka, Takaki Nakagawa
  • Patent number: 8309678
    Abstract: Provided is a solid polymer electrolyte having increased heat resistance and high proton conductivity and a proton conductive membrane composed of the electrolyte. Also provided is a copolymer having a sulfonic acid group.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: November 13, 2012
    Assignee: JSR Corporation
    Inventors: Toshiaki Kadota, Yoshitaka Yamakawa
  • Publication number: 20120165541
    Abstract: The present invention relates to method for the preparation of an ?-amino-alkane(thio)amide having the general formula (6) Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.
    Type: Application
    Filed: July 30, 2010
    Publication date: June 28, 2012
    Inventors: Martin Albert, Dominic De Souza
  • Publication number: 20120136151
    Abstract: The present invention relates to novel intermediate compounds used in preparing Rosuvastatin or the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a method for preparing Rosuvastatin or the pharmaceutically acceptable salts thereof from the intermediates. The preparation method of the present invention has the effect of providing Rosuvastatin hemi-calcium salts with an excellent yield rate.
    Type: Application
    Filed: April 8, 2010
    Publication date: May 31, 2012
    Inventors: Hongwoo Lee, Daejong Park, Choongleol Yoo, Donghyuk Nam, Hohyung Ryu, Dongjin Kim
  • Publication number: 20120021912
    Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: January 18, 2010
    Publication date: January 26, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20120021909
    Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: January 25, 2010
    Publication date: January 26, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20120021907
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: January 6, 2010
    Publication date: January 26, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20120004165
    Abstract: Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments The invention relates to heterocyclically substituted methoxyphenyl derivatives with an oxo group, and to physiologically compatible salts thereof. The invention relates to compounds of the formula I in which R1, R2, R3, R4, R10, X, n, B1, B2, B3 and B4 are each defined as specified, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
    Type: Application
    Filed: June 7, 2011
    Publication date: January 5, 2012
    Applicant: SANOFI
    Inventors: Stefanie KEIL, Elisabeth DEFOSSA, Viktoria DIETRICH, Siegfried STENGELIN, Andreas HERLING, Guido HASCHKE, Thomas KLABUNDE
  • Patent number: 7932277
    Abstract: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: April 26, 2011
    Assignees: InterMune, Inc., Array Biopharma Inc.
    Inventors: Scott Seiwert, Steven W. Andrews, Leonid Beigelman, Lawrence M. Blatt, Brad Buckman, Kevin R. Condroski, Yutong Jiang, Robert J. Kaus, April L. Kennedy, Timothy S. Kercher, Michael A. Lyon, Bin Wang
  • Patent number: 7906608
    Abstract: A nitrogen-containing aromatic compound is represented by Formula (1). A polymer is obtained by polymerizing the compound. wherein X is an atom or a group selected from halogen atoms other than fluorine and —OSO2Rb (wherein Rb is an alkyl group, a fluorine-substituted alkyl group or an aryl group); Y is at least one structure selected from the group consisting of —CO—, —SO2—, —SO—, —CONH—, —COO—, —(CF2)1— (wherein l is an integer of 1 to 10) and —C(CF3)2—; Z is at least one structure selected from the group consisting of a direct bond, —O— and —S—; R20 is a nitrogen-containing heterocyclic group; q is an integer of 1 to 5; and p is an integer of 0 to 4.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: March 15, 2011
    Assignee: JSR Corporation
    Inventors: Makoto Higami, Igor Rozhanskii, Yoshitaka Yamakawa
  • Publication number: 20110009448
    Abstract: A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 13, 2011
    Inventors: Nigel Vicker, Su Xiangdong, Dharshini Ganeshapillai, Atul Purohit, Michael John Reed, Barry Victor Lloyd Potter
  • Publication number: 20100292285
    Abstract: A pharmaceutical composition of fungicide including at least a compound represented by Formula (I). The pharmaceutical composition of fungicide can further include an emulsifier, a cosolvent, a stabilizer, and a solvent. The fungicide can prevent and treat powdery mildew, downy mildew, gray mold, brown spot, scab of vegetables and fruits, southern leaf blight of corn, rice false smut, citrus stem-end rot, and rape sclerotinia rot, with high efficiency, low toxicity, and relative environmental friendliness. A method of preparing the fungicide and a method of using thereof are also provided.
    Type: Application
    Filed: July 27, 2010
    Publication date: November 18, 2010
    Inventors: Guangfu YANG, Peiliang ZHAO, Wei HUANG, Zuming LIU, Hualong WU
  • Publication number: 20100098634
    Abstract: Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
    Type: Application
    Filed: July 24, 2009
    Publication date: April 22, 2010
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Wei Zhang, Umesh B. Gangadharmath, Dhanalakshmi Kasi, Kai Chen, Anjana Sinha, Eric Wang, Gang Chen, Peter J.H. Scott, Henry Clifton Padgett, Qianwa Liang, Zhiyong Gao, Tieming Zhao, Chunfang Xia
  • Publication number: 20090239917
    Abstract: Compounds of formula (I): wherein: R1 represents a (C3-C8)cycloalkyl group, R2 represents a group of formula (II) as defined in the description, X represents an oxygen atom or an N—OR? group wherein R? represents a hydrogen atom, a linear or branched (C1-C6)alkyl group, an aryl group or an aryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched. Medicinal products containing the same which are useful as hypoglycaemic and hypolipaemic agents.
    Type: Application
    Filed: March 5, 2007
    Publication date: September 24, 2009
    Applicant: Les Laboratoires Servier
    Inventors: Aurelie Hurtevent, Jean-Martial L'Helgoual'ch, Pascal Carato, Nicolas Lebegue, Veronique Leclerc, Morgan Le Naour, Pascal Berthelot, Catherine Dacquet, Alain Ktorza, Daniel-Henri Caignard
  • Publication number: 20090149623
    Abstract: A nitrogen-containing aromatic compound is represented by Formula (1). A polymer is obtained by polymerizing the compound. wherein X is an atom or a group selected from halogen atoms other than fluorine and —OSO2Rb (wherein Rb is an alkyl group, a fluorine-substituted alkyl group or an aryl group); Y is at least one structure selected from the group consisting of —CO—, —SO2—, —SO—, —CONH—, —COO—, —(CF2)l— (wherein l is an integer of 1 to 10) and —C(CF3)2—; Z is at least one structure selected from the group consisting of a direct bond, —O— and —S—; R20 is a nitrogen-containing heterocyclic group; q is an integer of 1 to 5; and p is an integer of 0 to 4.
    Type: Application
    Filed: June 30, 2006
    Publication date: June 11, 2009
    Applicant: JSR Corporation
    Inventors: Makoto Higami, Igor Rozhanskii, Yoshitaka Yamakawa
  • Publication number: 20080319032
    Abstract: This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells.
    Type: Application
    Filed: November 13, 2007
    Publication date: December 25, 2008
    Inventors: Nigel H Greig, Mark Mattson, Xiaoxiang Zhu, Qian-Sheng Yu, Harold Wayne Holloway
  • Publication number: 20080293684
    Abstract: The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
    Type: Application
    Filed: July 26, 2005
    Publication date: November 27, 2008
    Inventors: Anthony B Pinkerton, Jean-Michel Vernier, Rowena V. Cube, John H. Hutchinson, Dehua Huang, Celine Bonnefous, Steven P. Govak, Theodore Kamenecka
  • Patent number: 7230020
    Abstract: A compound having Formula I R1—Z—R2Formula I wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is —X—Y—L— or —Y—X—L— wherein either X is selected from —S(?O)(?O)— and —C(?O)—; and Y is —NR3—; or X is selected from —S(?O)(?O)— and —S—, and Y is —C(R4)(R5)—; L is an optional linker; and R3, R4 and R5 are each independently selected from H and hydrocarbyl; and wherein when R2 comprises the following structural moiety wherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R1—C(?O)—NR3—L—R2; R1—S(?O)(?O)—C(R4)(R5)—L—R2; R1—S—C(R4)(R5)—L—R2; R1—NR3—S(?O)(?O)—L—R2; R1—NR3—C(?O)—L—R2; R1—C(R4)(R5)—S(?O)(?O)—L—R2; and R1—C(R4)(R5)—S—L—R2.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: June 12, 2007
    Assignee: Sterix Limited
    Inventors: Nigel Vicker, Su Xiangdong, Dharshini Ganeshapillai, Atul Purohit, Michael John Reed, Barry Victor Lloyd Potter
  • Patent number: 6995262
    Abstract: The invention relates to a novel polymethine dyes containing at least one acylsulfonamido group of the formula (I) in which n, Y, A and R have the meaning given in the claims, and at least one compound of the formulae (a) to (n) given in the claims. The polymethine dyes according to the invention are suitable for use as dyes and/or labels, in particular for staining or labeling biomolecules.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: February 7, 2006
    Assignee: Bayer CropScience AG
    Inventors: Geert Deroover, Michael Missfeldt, Lydia Simon
  • Patent number: 6939967
    Abstract: Process for production of non-proteinogenic L-amino acids by direct fermentation of a microorganism strain known per se having a deregulated cysteine metabolism in a manner known per se, which comprises adding, during the fermentation, a nucleophilic compound to the fermentation batch in a manner such that this leads to the production of non-proteinogenic L-amino acids by the microorganism strain.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: September 6, 2005
    Assignee: Consortium für elektrochemische Industrie GmbH
    Inventor: Thomas Maier
  • Patent number: 6777418
    Abstract: The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: August 17, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Jean-Marc Lapierre, David Mark Rotstein, Eric Brian Sjogren
  • Patent number: 6696456
    Abstract: Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where R1, R2, R3, R4, R5, R6, G and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: February 24, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Stanislaw Pikul, Norman Eugene Ohler, Kelly Michelle Solinsky, Neil Gregory Almstead, Biswanath De, Michael George Natchus
  • Patent number: 6586463
    Abstract: Compounds having the general structure: which are useful for the treatment of a variety of diseases and conditions, such as bone disorders.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: July 1, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Mitchell Anthony deLong, David Lindsey Soper, John August Wos, Biswanath De
  • Publication number: 20030105088
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Application
    Filed: January 17, 2002
    Publication date: June 5, 2003
    Applicant: GUILFORD PHARMACEUTICALS INC.
    Inventors: Takashi Tsukamoto, Pavel Majer, Doris Stoermer, Barbara S. Slusher
  • Publication number: 20030055263
    Abstract: The present application relates to the use of the carboxylic acid derivatives of general formula
    Type: Application
    Filed: July 10, 2002
    Publication date: March 20, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Iris Kauffmann-Hefner, Norbert Hauel, Klaus Damm, Andreas Schnapp
  • Publication number: 20030018199
    Abstract: A process is provided for preparing chiral diol sulfones of the structure 1
    Type: Application
    Filed: May 30, 2002
    Publication date: January 23, 2003
    Inventors: Paul R. Brodfuehrer, Thomas R. Sattelberg, Joydeep Kant, Xinhua Qian
  • Patent number: 6362138
    Abstract: This invention relates to compounds which are suitable as ash-free antiwear additives and antioxidants, to lubricant compositions comprising said compounds as well as to their use. are particularly preferred. In the preferred compounds I′, R2 is isooctyloxycarbonylmethyl, R3 is isooctyloxycarbonylmethylthiomethyl and R4 is hydrogen; or R2 is tert-nonyl and R3 is tert-nonylthiomethyl and R4 is hydrogen; or R2 is isooctyloxycarbonylmethyl, R3 is hydrogen and R4 is isooctyloxycarbonylmethylthiomethyl; or R2 is tert-nonyl, R3 is hydrogen and R4 I is tert-nonylthiomethyl.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: March 26, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hugo Camenzind, Samuel Evans, Alfred Dratva, Peter Hänggi
  • Publication number: 20010044454
    Abstract: A thrombin receptor antagonist having the formula 1
    Type: Application
    Filed: January 30, 2001
    Publication date: November 22, 2001
    Inventors: Philippe G. Nantermet, James C. Barrow, Harold G. Selnick
  • Patent number: 6319925
    Abstract: Oxime ethers of formula (I) in which a) X is an N atom and Y is an oxygen atom or NH, or b) X is CH and Y is an oxygen atom, in which furthermore R1 is C1-C4alkyl; R2 is hydrogen, C1-C4alkyl or cyclopropyl; and in which R3 and R4 are as defined herein, are fungicidal, acaricidal and insecticidal active ingredients for agriculture. They can be employed as formulated crop protection compositions.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: November 20, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventor: Hugo Ziegler
  • Patent number: 6313289
    Abstract: Crystalline 2-(amninothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid with an amine of formula N(R1)(R2)(R3), wherein R1, R2, and R3 have various meanings, a crystalline sulphuric acid addition salt of a 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid; and the use of these salts in the production of cefixime, e.g. in form of a trihydrate.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: November 6, 2001
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Ludwig Miller, Hubert Sturm, Werner Veit, Martin Decristoforo, Siegfried Wolf
  • Patent number: 6255480
    Abstract: Aminothiazole derivatives having the carboxyl activated by means of thioesters, said derivatives being condensable with &bgr;-lactam nuclei to yield &bgr;-lactam antibiotics
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: July 3, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Maurizio Zenoni, Mario Leone, Maurizio Serra, Mauro Filippi
  • Patent number: 6204380
    Abstract: Carboxylic acid ester derivatives of formula (1): wherein R is C1-C6 alkyl, R2 and R3 are independently hydrogen or C1-C3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): wherein R3 and Q are as defined above, with malonic acid monoester derivatives of formula (6): wherein R and R2 are as defined above, in the presence of a base.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: March 20, 2001
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Takashi Furukawa
  • Patent number: 6150307
    Abstract: This invention relates to compounds which are suitable as ash-free antiwear additives and antioxidants, to lubricant compositions comprising said compounds as well as to their use. Compounds of formulae ##STR1## are particularly preferred. In the preferred compounds I',R.sub.2 is isooctyloxycarbonylmethyl, R.sub.3 is isooctyloxycarbonylmethylthiomethyl and R.sub.4 is hydrogen; orR.sub.2 is tert-nonyl and R.sub.3 is tert-nonylthiomethyl and R.sub.4 is hydrogen; orR.sub.2 is isooctyloxycarbonylmethyl, R.sub.3 is hydrogen and R.sub.4 is isooctyloxycarbonylmethylthiomethyl; orR.sub.2 is tert-nonyl, R.sub.3 is hydrogen and R.sub.4 I is tert-nonylthiomethyl.In the preferred compounds II',R.sub.2 and R.sub.2 ' are isooctyloxycarbonylmethyl, R.sub.3 and R.sub.3 ' are isooctyloxycarbonylmethylthiomethyl and R.sub.4 and R.sub.4 ' are hydrogen; orR.sub.2 and R.sub.2 ' are tert-nonyl, R.sub.3 and R.sub.3 ' are tert-nonylthiomethyl and R.sub.4 and R.sub.4 ' are hydrogen; orR.sub.2 and R.sub.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: November 21, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hugo Camenzind, Samuel Evans, Alfred Dratva, Peter Hanggi
  • Patent number: 6100406
    Abstract: Suitable lubricant additives are the compounds of formulae wherein the substituents and groups have the following preferred meanings:R.sub.1 =H; R.sub.2 =methyl or tert-butyl; R.sub.3 =tert-butyl;s=0, 1 or 2;R.sub.4 =--A--[(C.sub.6 H.sub.2)(methyl or tert-butyl)(OH)(tert-butyl)];A=--CH.sub.2 CH.sub.2 O--(C.dbd.O)--CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH(CH.sub.3)--O--(C.dbd.O)--CH.sub.2 CH.sub.2.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: August 8, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hugo Camenzind, Alfred Dratva, Peter Hanggi
  • Patent number: 6020339
    Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: February 1, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Helene Perrier, Yongxin Han, Christopher Bayly, Dwight Mac Donald, Andre Giroux, Robert N. Young
  • Patent number: 5980779
    Abstract: A process for producing a liquid crystalline compound represented by the following general formula (A): ##STR1##
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: November 9, 1999
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Junichi Hanna, Masahiro Funahashi, Masanori Akada, Masayuki Ando, Yozo Kosaka
  • Patent number: 5942535
    Abstract: The present invention relates to heterocyclic compounds of the formula ##STR1## in which R.sup.1 -R.sup.7, B, a and X have the meanings recited in the specification. These compounds are usable in the treatment of diseases of the rheumatoid group and for the prevention of allergically induced diseases.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: August 24, 1999
    Assignee: Merckle GmbH
    Inventors: Stefan Laufer, Hans Gunther Striegel, Gerd Dannhardt
  • Patent number: 5777162
    Abstract: Described herein are compounds of Formula (XX) and Formula (XXIV), shown below, and processes of making same. ##STR1## wherein p is 0 ##STR2## wherein p is 1, and Y is chlorine or bromine.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: July 7, 1998
    Assignee: Zeneca Limited
    Inventors: Ian Richard Matthews, Christopher Richard Ayles Godfrey, John Martin Clough
  • Patent number: 5700819
    Abstract: Unique benzothiazole derivatives which exert superior aldose redactase inhibiting actions are unexpectedly and advantageously useful in the prophylactic and therapeutic treatment of diabetic complications. A benzothiazole derivative compound of the formula (1): ##STR1## wherein X is halogen, R.sup.1 and R.sup.2, which are the same or different, are each independently hydrogen or halogen, A is a methylene group or a sulfur atom, and --B--COOR.sup.3 is a group as defined in the specification; or a pharmaceutically acceptable salt and a pharmaceutical composition comprising the same which is a useful prophylactic or therapeutic agent for the treatment of diabetic complications.
    Type: Grant
    Filed: November 22, 1995
    Date of Patent: December 23, 1997
    Assignee: Grelan Pharmaceutical Co., Ltd.
    Inventors: Tomoji Aotsuka, Naoki Abe, Naoki Ashizawa
  • Patent number: 5674811
    Abstract: A cyanoketone derivatives of the following formula (1) ##STR1## which are characterized by excellent herbicidal activity and effectiveness against a variety of broad leafed weeds, including barnyard grass, green foxtail, velvet leaf, livid amaranth and hairy beggar ticks.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: October 7, 1997
    Assignee: Tokuyama Corporation
    Inventors: Toshio Kitajima, Tadashi Kobutani, Shozo Kato, Masao Yamaguchi, Masahiko Ishizaki, deceased
  • Patent number: 5648370
    Abstract: There are disclosed compounds of formula I,Ar--CH.sub.2 CH.sub.2 --NH--CR.sup.1 R.sup.2 --X--Y Iin whichAr represents a group, ##STR1## X represents a C.sub.1-12 alkylene chain optionally interrupted or terminated by one or more groups selected from --S(O).sub.n --, --O--, --C(Z)--, CR.sup.6 R.sup.7, phenylmethyne, --NR.sup.8 --, --CONH--, --NHCO-- and --NHCONH--,Y represents an optionally substituted aryl or cycloalkyl group,Z represents O or S,R.sup.1, R.sup.2, R.sup.5 and R.sup.9 each independently represent hydrogen or alkyl C.sub.1-6,R.sup.3 and R.sup.4 represent hydrogen, or R.sup.3 and R.sup.4 together form a group --S--, --NR.sup.9 -- or --CH.sub.2 --,R.sup.6 and R.sup.7 independently represent hydrogen, alkyl C.sub.1-6, fluoro, cyano, or CF.sub.3, provided that at least one of R.sup.6 and R.sup.7 is other than hydrogen,R.sup.8 represents hydrogen or alkyl C.sub.1-6, or when X is interrupted or terminated by more than one --NR.sup.8 -- group may together with another R.sup.8 group form the chain --CH.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: July 15, 1997
    Assignee: Astra Pharmaceuticals Limited
    Inventors: Roger V. Bonnert, Roger C. Brown, David R. Cheshire, Francis Ince, John Dixon
  • Patent number: 5629265
    Abstract: Disclosed herein are cyanoketone derivatives of the following formula (1) ##STR1## such as 1-cyano-1-piperidinocarbonyl-3-[4-(2-chloro-4-trifluoromethylphenoxy)pheno xy]-2-butanone, 1-cyano-1-piperidinocarbonyl-3-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy )phenoxy]-2-butanone, 1-cyano-1-(N-methyl-N-dichlorophenyl)aminocarbonyl-3-[4-(2-quinoxalyloxy)p henoxy]-2-butanone, 1-cyano-1-(N,N-dibutyl)aminocarbonyl-3-[4-(3-chloro-5-trifluoromethyl-2-py ridyloxy)phenoxy-2-butanone, and the like, which are characterized by excellent herbicidal activity and effectiveness against a variety of gramineous weeds.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: May 13, 1997
    Assignee: Tokuyama Corporation
    Inventors: Masahiko Ishizaki, Seiji Nagata, Junji Takenaka