Chalcogen Attached Indirectly To The Polycyclo Ring System By Nonionic Bonding Patents (Class 548/260)
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Patent number: 7825257Abstract: The synthesis of benzotriazole monomers and the use of the benzotriazole monomers and one or more other monomers to prepare ultraviolet (UV) light absorbing polymer compositions. The synthetic methods described in this application provide a significant improvement over the previous methods used to prepare benzotriazole monomers.Type: GrantFiled: October 17, 2008Date of Patent: November 2, 2010Assignee: Bausch & Lomb IncorporatedInventors: Keshav Deo, Chandrakant Chunilal Shah, Kalpesh Patel, Nilpesh Patel, Viral Parekh, Ronak Patel, Jignesh Soni, Hiral Shah, David E. Seelye, Mahendra P. Nandu
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Publication number: 20100249367Abstract: This invention is about a material which provides to observe all colors necessary for display technologies in a very small potential range. The material is a derivative of benzotriazole containing donor acceptor type conducting polymer which is soluble, fluorescent and can be used in LEDs, solar cells, electrochromic devices, smart windows and many other technologies.Type: ApplicationFiled: March 30, 2010Publication date: September 30, 2010Inventors: Levent Kamil Toppare, Abidin Balan, Derya Baran
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Publication number: 20100210854Abstract: Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.Type: ApplicationFiled: February 19, 2010Publication date: August 19, 2010Inventors: Vladimir V. Popik, Andrei A. Poloukhtine
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Patent number: 7763184Abstract: A light stabilizing liquid matter, that can be added to a composition to be stabilized and that has a storage stability high enough for storage before being added to the composition, includes a product formed by mixing: (A) 2-(2-hydroxy-3-?-cumyl-5-tert-octylphenyl)-2H-benzotriazole with (B) at least one benzotriazole compound other than 2-(2-hydroxy-3-?-cumyl-5-tert-octylphenyl)-2H-benzotriazole plus a hindered amine compound, or with (B?) at least one compound selected from the group consisting of a benzotriazole compound other than 2-(2-hydroxy-3-?-cumyl-5-tert-octylphenyl)-2H-benzotriazole, and a hindered amine compound, and (C) an anti-oxidant including at least one compound selected from the group consisting of a phosphite compound and a phenolic compound.Type: GrantFiled: July 19, 2007Date of Patent: July 27, 2010Assignee: Double Bond Chem. Ind. Co., Ltd.Inventors: Ching-Yie Su, Ming-Ho Chiu, Maw-Der Tsay
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Patent number: 7655805Abstract: A method for synthesizing benzotriazole comprises acts of: preparing a first solvent comprising 2-(2-hydroxy-5-methylphenyl) benzotriazole, a basic agent and molecular sieves and a second solvent comprising 3-chloro-2-alkyl propylene; mixing the solvents; and heating the solvents. This method requires only one reaction vessel and produces few by-products, therefore is simpler and cheaper to produce. Furthermore, the molecular sieves are cheaper than catalysts in conventional reactions and may be recycled, giving even greater economic benefits.Type: GrantFiled: April 24, 2008Date of Patent: February 2, 2010Assignee: UFC CorporationInventors: Ling Lu, Po-Hsuan Wei, Chung-Ning Fan, Yu-Cheng Lee, Hui-Ling Yang, Yu-Chin Lee
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Publication number: 20100012889Abstract: Dihydroxybenzotriazole UV absorbing compounds that are particularly useful in ophthalmic devices are disclosed.Type: ApplicationFiled: July 10, 2009Publication date: January 21, 2010Applicant: Alcon, Inc.Inventor: David L. Jinkerson
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Patent number: 7625889Abstract: The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I): Wherein X, Y, Z, A, B, D, Ar, R1 and R2 are as defined herein. The compounds of this invention are selective 5HT2A antagonists, and are therefore, useful in treating a variety of diseases including but not limited to a wide variety of sleep disorders as disclosed and claimed herein.Type: GrantFiled: July 25, 2007Date of Patent: December 1, 2009Assignee: Aventis Pharmaceuticals Inc.Inventors: Paul Robert Eastwood, Hazel Hunt, David Mark Fink, Helen Katherine Smith, Richard Simon Todd
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Publication number: 20090270632Abstract: A method for synthesizing benzotriazole comprises acts of: preparing a first solvent comprising 2-(2-hydroxy-5-methylphenyl) benzotriazole, a basic agent and molecular sieves and a second solvent comprising 3-chloro-2-alkyl propylene; mixing the solvents; and heating the solvents. This method requires only one reaction vessel and produces few by-products, therefore is simpler and cheaper to produce. Furthermore, the molecular sieves are cheaper than catalysts in conventional reactions and may be recycled, giving even greater economic benefits.Type: ApplicationFiled: April 24, 2008Publication date: October 29, 2009Inventors: Ling Lu, Po-Hsuan Wei, Chung-Ning Fan, Yu-Cheng Lee, Hui-Ling Yang, Yu-Chin Lee
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Publication number: 20090264657Abstract: Described is the use of specific merocyanine derivatives for protecting body-care and household products from photolytic and oxidative degradation. These compounds perform outstanding UV absorber properties.Type: ApplicationFiled: July 19, 2006Publication date: October 22, 2009Inventors: Barbara Wagner, Oliver Reich
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Patent number: 7511034Abstract: Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.Type: GrantFiled: January 11, 2006Date of Patent: March 31, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Eu-Gene Oh, Sung-Bo Ko, Kyung-Hwa Kim, In-Kyu Chang, Dennis W. Choi, Laura L. Dugan, Jae-Young Koh, In-Jae Shin, Moo-Ho Won
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Publication number: 20090042875Abstract: The present invention relates to substituted heterocyclic compounds and compositions comprising a substituted heterocyclic compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more substituted heterocyclic compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more substituted heterocyclic compounds. The present invention further relates to articles of manufacture and kits comprising one or more substituted heterocyclic compounds.Type: ApplicationFiled: September 29, 2008Publication date: February 12, 2009Inventors: George W. Muller, Hon-Wah Man
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Patent number: 7388006Abstract: The present invention relates to non-steroidal progestins of the general formula (I) wherein R1 and R2 are independently of each other —H or —F, R3 is —CH3 or —CF3, and Ar is or a pharmaceutically acceptable derivative or analogue thereof. These progestins are suitable for selectively modulating progesterone receptor mediated effects in different target tissues, particularly in uterine tissue versus breast tissue. Therefore, the progestins of the present invention, optionally in combination with estrogens, may be used for contraception (in particular in estrogen-free oral contraceptives), hormone replacement therapy and the treatment of gynecological disorders. The present invention furthermore relates to methods for selectively modulating progesterone receptor mediated effects in different target tissues or organs.Type: GrantFiled: March 11, 2003Date of Patent: June 17, 2008Assignee: Bayer Schering Pharma AGInventors: Norbert Schmees, Manfred Lehmann, Ulrike Fuhrmann, Peter Muhn, Christa Hegele-Hartung, Michael Klotzbuecher
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Publication number: 20080139566Abstract: Oxetane-containing nucleosides, particularly non-reducing psiconucleoside oxetanes are described herein. Therapeutic application of these oxetane compounds toward the treatment of nucleoside analog related disorders such as disorders involving cellular proliferation and infection are also described.Type: ApplicationFiled: January 24, 2008Publication date: June 12, 2008Inventors: Amy R. Howell, Rosa C. Taboada, Stewart K. Richardson
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Patent number: 7381762Abstract: Hydroxybenzotriazole-based compounds are useful for ultraviolet light absorbing additives for a variety of applications. Such compounds have particular usefulness in various applications, including plastics, automotive, coatings, and food packaging applications. Such inventive compound exhibit excellent UV radiation absorbing activity, high thermal stability, excellent low fogging, low extraction/low migration rates, and high lightfastness levels, particularly when incorporated within certain media and/or on the surface of certain substrates, particularly polyesters, polyolefins, and polyurethanes. Block copolymer chain or chains consisting of poly(oxyalkylene) and/or aliphatic polyester segments can be conveniently tailored to increase the solubility or compatibility in different solvents or resins thereby permitting the introduction of such excellent UV absorbing chromophores within diverse media and/or or diverse substrates.Type: GrantFiled: August 20, 2004Date of Patent: June 3, 2008Assignee: Milliken & CompanyInventor: Jusong Xia
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Patent number: 7368479Abstract: The invention relates to ?-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally substituted aryl or heteroaryl group, R1, and R2 stand independently of each other for hydrogen, optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R3 designates hydrogen, C3-C5alkenyl, C3-C5alkynyl or optionally substituted C1,-C5alkyl; R4 is optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R5 and R6 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R7, and R8 are independently of each other hydrogen or optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally suType: GrantFiled: June 18, 2003Date of Patent: May 6, 2008Assignee: Syngenta Crop Protection, Inc.Inventors: Martin Eberle, Daniel Stierli, Urs Müller
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Patent number: 7326744Abstract: The present invention relates to a low dusting crystalline 2,2?-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol] type I crystal transformation which exhibits diffraction peaks at diffraction angles (2?±0.1°) of 7.1°, 8.6°, 14.3°, 16.1°, 18.1° and 23.0° in powder X-ray diffraction analysis with Cu-K? radiation; a low dusting 2,2?-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol] type II crystal transformation which does not exhibit a distinct diffraction peak but an amorphous halo in powder X-ray diffraction analysis with Cu-K? radiation; a mixture thereof; a method for preparing them; and a UV light absorber, an emulsion composition and a polymer material using them.Type: GrantFiled: June 5, 2002Date of Patent: February 5, 2008Assignee: Chempiro Kaei Kaisha, LimitedInventors: Naohiko Fukuoka, Yoshinori Ohmae, Yuichi Kaneko, Masayuki Nishimatsu
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Publication number: 20080027226Abstract: Disclosed are electroluminescent devices that comprise organic layers that contain certain 2H-benzotriazole compounds. The 2H-benzotriazole compounds are suitable components of blue-emitting, durable, organo-electroluminescent layers. The electroluminescent devices may be employed for full color display panels in, for example, mobile phones, televisions and personal computer screens.Type: ApplicationFiled: November 26, 2004Publication date: January 31, 2008Inventors: Jonathan Rogers, Francois Maike, Norihisa Dan
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Patent number: 7229988Abstract: The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds of the invention have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.Type: GrantFiled: June 5, 2003Date of Patent: June 12, 2007Assignee: Samsung Electronics Co., Ltd.Inventors: Eu-Gene Oh, Sung-Bo Ko, Kyung-Hwa Kim, In-Kyu Chang, Dennis W. Choi, Laura L. Dugan, Jae-Young Koh, In-Jae Shin, Moo-Ho Won
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Patent number: 7157586Abstract: Benzotriazole UV absorbers substituted with a ultra long ester or amide moiety wherein the ester or amide group is a hydrocarbyl group of 25 to 100 carbon atoms or is a group of alkyl of 25 to 100 carbon atoms interrupted by 5 to 39 oxygen atoms and terminated with an omega-OH or an omega-OR group exhibit excellent stabilization efficacy while they concomitantly do not bloom when incorporated into polyolefin films. These benzotriazole UV absorbers also provide excellent protection to white, dyed, dipped, unscented and/or scented candle wax from discoloration and degradation.Type: GrantFiled: February 11, 2002Date of Patent: January 2, 2007Assignee: Ciba Specialty Chemcials CorporationInventors: Mervin Wood, Ramanathan Ravichandran, Douglas Wayne Horsey, Anunay Gupta, Deborah DeHessa, Luther A. R. Hall, Andrea Smith, Stephen Mark Andrews
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Patent number: 7129198Abstract: The use of benzotriazole UV absorbers of formula wherein A is a radical of formula B is a radical of formula R1, R2, R3, R4, R5 and R6 are each independently of the others hydrogen, C1–C16alkyl; C5–C7cycloalkyl; halogen; R9 is hydrogen, C1–C12alkyl; or C5–C7cycloalkyl; R7, R8 and R10 are each independently of the others hydrogen, C1–C12alkyl, C5–C7cycloalkyl, C1–C12hydroxyalkyl; X is halogen; a radical of formula sulfate, phosphate, lactate, citrate, tartrate; R11 is C1–C12alkyl; or C5–C7cycloalkyl; R12 and R13 are each independently of the other hydrogen; or C1–C5alkyl; x is from 0 to 10; and y is from 1 to 20; in the cosmetic treatment of human hair for protection against UV radiation is described.Type: GrantFiled: June 30, 2005Date of Patent: October 31, 2006Assignee: Ciba Specialty Chemicals CorporationInventor: Thomas Ehlis
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Patent number: 7119210Abstract: Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization.Type: GrantFiled: January 8, 2004Date of Patent: October 10, 2006Assignee: Alcon, Inc.Inventor: Douglas C. Schlueter
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Patent number: 7078421Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.Type: GrantFiled: March 19, 2003Date of Patent: July 18, 2006Assignee: Metabolex, Inc.Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
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Patent number: 7074906Abstract: Provided is a novel one-pot, organic solvent-free process for the preparation of 2-(2-nitrophenylazo) substituted phenols. The 2-(2-nitrophenylazo) substituted phenols are precursors for hydroxyphenylbenzotriazole UV absorbers.Type: GrantFiled: November 26, 2002Date of Patent: July 11, 2006Assignee: Ciba Specialty Chemicals CorporationInventors: Stephen Daniel Pastor, Joseph Suhadolnik, Deborah Judd, Mervin Gale Wood
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Patent number: 7066184Abstract: The use of benzotriazole UV absorbers of formula (1), wherein A is a radical of formula (1a); (1b); or (1c); B is a radical of formula (1d); (1e); (1f), (1g); (1h); (1i); (1k); (1l); (1m); or (1n); R1, R2, R3, R4, R5 and R6 are each independently of the others hydrogen, C1–C16alkyl; C5–C7cycloalkyl; halogen; R9 is hydrogen, C1–C12alkyl; or C5–C7cycloalkyl; R7, R8 and R10 are each independently of the others hydrogen, C1–C12alkyl C5–C7cycloalky, C1–C12hydroxyalkyl; X is halogen; a radical of formula (1s); (1t); or (1u); sulfate, phosphate, lactate, citrate, tartrate; R11 is C1–C12alkyl; or C5–C7cycloalkyl; R12 and R13 are each independently of the other hydrogen; or C1–C5alkyl; x is from 0 to 10; and y is from 1 to 20; in the cosmetic treatment of human hair for protection against UV radiation is described.Type: GrantFiled: November 7, 2000Date of Patent: June 27, 2006Assignee: Ciba Specialty Chemicals CorporationInventor: Thomas Ehlis
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Patent number: 6946468Abstract: The present invention relates to inhibitors of ras farnesylation of the Formula I wherein: R1 is for example H and further values as defined in the specification; R2 is for example H and further values as defined in the specification; R3 is for example H or a substituent having values as defined in the specification; p is 0-3 in which R3 values can be the same or different; L is a linking moiety for example —CH2—NH— and further values as defined in the specification; A is selected from phenyl; naphthyl; a 5-10 membered monocyclic or bicyclic heteroaryl ring containing upto 5 heteroatoms where the heteroatoms are independently selected from O, N & S; or a —S—S— dimer thereof when R2?H; or a N-oxide or a pharmaceutically-acceptable salt, prodrug or solvate thereof. Processes for their preparation their use as therapeutic agents and pharmaceutical compositions containing them.Type: GrantFiled: August 13, 1997Date of Patent: September 20, 2005Assignee: Zeneca LimitedInventors: Francis Thomas Boyle, James Michael Wardleworth
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Patent number: 6930136Abstract: Benzotriazole adducts contain a benzotriazole segment and a segment with a curable and polymerizable functionality, or an adhesion promoting functionality, particularly suitable for use on metal substrates or in adhesive, sealant or coating compositions for use in proximity to metal substrates.Type: GrantFiled: September 28, 2001Date of Patent: August 16, 2005Assignee: National Starch and Chemical Investment Holding CorporationInventors: Osama M. Musa, Harry Richard Kuder
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Patent number: 6908936Abstract: The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the treatment of respiratory syncytial virus infection.Type: GrantFiled: November 7, 2002Date of Patent: June 21, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Kuo-Long Yu, Rita Lee Civiello, Mark R. Krystal, Kathleen F. Kadow, Nicholas A. Meanwell
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Patent number: 6864254Abstract: An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular diseases, or circulatory diseases. The novel hydroxyformamidine derivative or pharmacologically acceptable salt thereof is also provided.Type: GrantFiled: November 1, 2000Date of Patent: March 8, 2005Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masakazu Sato, Noriyuki Miyata, Takaaki Ishii, Yuko Kobayashi, Hideaki Amada
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Patent number: 6858607Abstract: The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: or pharmaceutically acceptable salts or prodrugs thereof, wherein: wherein A, R1, R2, R5, X, Y, and Z, are defined herein and B is a fused thiazole, oxazole, 2-imino-imidazole, 2,1,3-thiadiazo-2-one, thiazol-2-one, oxazol-2-one, imidazol-2-thione, thiazol-2-thione, oxazol-2-thione, imidazoline, oxazoline, thiazoline, triazole, oxazine, oxazine-2,3-dione, or piperazine ring. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.Type: GrantFiled: May 16, 2002Date of Patent: February 22, 2005Assignee: Cytovia, Inc.Inventors: Sui Xiong Cai, Lifen Xu, Richard Storer, Giorgio Attardo
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Patent number: 6818206Abstract: The invention relates to the use of at least one amphiphilic copolymer comprising at least one hydrophilic block and at least one hydrophobic block to stabilize dispersions of insoluble organic compounds comprising at least one group that absorbs UV radiation, which is in the form of particles with a mean size of between 10 nm and 5 &mgr;m, and also to dispersions stabilized with these amphiphilic copolymers and to cosmetic compositions for topical application, in particular antisun compositions, containing them.Type: GrantFiled: October 10, 2002Date of Patent: November 16, 2004Assignee: L'OrealInventors: Didier Candau, Fabien Aubert
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Patent number: 6815550Abstract: Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzoic ring, for example a trifluoromethyl group, which involves digitizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.Type: GrantFiled: December 10, 2002Date of Patent: November 9, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin G. Wood, Deborah DeHessa, Joseph Suhadolnik, Andrew B. Naughton, Jerome Sanders, Jacqueline Lau, Rong Xiong, Joseph Babiarz
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Patent number: 6800676Abstract: 2H-Benzotriazole UV absorbers substituted at the 3-position and/or the 5-position of the phenyl ring by a phenyl moiety which is substituted by a heteroatom are particularly photostable in automotive coatings, and are of low color and exhibit low volatility in thermoplastic compositions.Type: GrantFiled: February 13, 2002Date of Patent: October 5, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin G. Wood, Stephen D. Pastor, Jacqueline Lau, Michael DiFazio, Joseph Suhadolnik
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Patent number: 6777433Abstract: The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.Type: GrantFiled: June 28, 2002Date of Patent: August 17, 2004Assignee: Merck Frosst Canada & Co.Inventors: Yves Leblanc, Claude Dufresne, Jacques Yves Gauthier, Robert Young
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Patent number: 6774238Abstract: Compounds of formula I or II where R is an aryl moiety, such as phenyl, naphthyl or biphenylyl, or is phenyl substituted by one or more trifluoromethyl, bromo or cyano, and E1 and E2 are independently hydrogen, alkyl, aralkyl and the like are prepared by reaction of a benzotriazole substituted on the 5-position of the benzo ring by a halogen atom with a arylboronic acid or ester in the presence of a transition-metal catalyst, such as palladium(II) diacetate. The benzotriazole compounds of formula I are particularly efficacious as stabilizers for automotive coatings and candle wax.Type: GrantFiled: April 17, 2003Date of Patent: August 10, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Stephen D. Pastor, Andrew B. Naughton, Robert Detlefsen, Mervin G. Wood, Joseph Suhadolnik, Anthony DeBellis, Deborah DeHessa
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Patent number: 6756499Abstract: The invention pertains to a process for the preparation of a novel UV absorbing diol of the general formula: wherein R1 is hydrogen, tert-butyl; X1 is selected the group consisting of hydrogen, halogen, tert-butyl and C1 to C12 alkoxy; R2 is C1 to C8 linear or branched alkyl.Type: GrantFiled: December 27, 2000Date of Patent: June 29, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Paragkumar Nathalal Thanki, Raj Pal Singh
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Patent number: 6703510Abstract: Compounds of formula I or II where R is an aryl moiety, such as phenyl, naphthyl or biphenylyl, or is phenyl substituted by one or more trifluoromethyl, bromo or cyano, and E1 and E2 are independently hydrogen, alkyl, aralkyl and the like are prepared by reaction of a benzotriazole substituted on the 5-position of the benzo ring by a halogen atom with a arylboronic acid or ester in the presence of a transition-metal catalyst, such as palladium (II) diacetate. The benzotriazole compounds of formula I are particularly efficacious as stabilizers for automotive coatings and candle wax.Type: GrantFiled: April 17, 2003Date of Patent: March 9, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Stephen D. Pastor, Andrew B. Naughton, Robert Detlefsen, Mervin G. Wood, Joseph Suhadolnik, Anthony DeBellis, Deborah DeHessa
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Patent number: 6677392Abstract: Photostable, silylated benzotriazole compounds of formula (I) or (II) where at least one of E1, E2, E5, E8, E9, G2 and G7 is a silylated group; and G2 and/or G7 is an electron withdrawing moiety or E1 is &agr;-cumyl, are both photostable and particularly compatible in high performance coatings such as organopolysiloxanes.Type: GrantFiled: August 1, 2001Date of Patent: January 13, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Ramanathan Ravichandran, Joseph Suhadolnik, Mervin G. Wood, Rong Xiong
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Publication number: 20030236418Abstract: A crosslinkable UV absorbing agent prepared by the following steps: (1) preparing a mixture of reactants comprising a UV absorbing compound (A) with multiple pendant hydroxyl groups and an unsaturated monoglycidyl compound (B) with both reactive glycidyl and vinyl groups; (2) mixing a base catalyst (C) with the mixture of reactants; (3) initiating a synthesis reaction of the crosslinkable UV absorbing agent under heating; and (4) recovering the resulting product after the synthesis reaction is completed. The crosslinkable UV absorbing agent is directly applicable in the lens formulation to replace conventional crosslinking agent and UV absorber used in the production of the soft contact lens without any purification or modification.Type: ApplicationFiled: June 24, 2003Publication date: December 25, 2003Inventor: Shinn-Gwo Hong
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Patent number: 6664395Abstract: The present invention relates to novel benzotriazoles of the formula I wherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of said heteroatoms atoms must be nitrogen; R2 is selected from the group consisting of hydrogen, (C1-C6)alkyl or other suitable substituents; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl or other suitable substituents; s is an integer from 0-5; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.Type: GrantFiled: April 4, 2002Date of Patent: December 16, 2003Assignee: Pfizer IncInventors: Michael A. Letavic, Mark A. Dombroski, Kim F. McClure, Ellen R. Laird
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Patent number: 6653484Abstract: Triazine, benzotriazole and benzophenone derivatives which are substituted or bridged with polyoxyalkylene groups, according to claim 1, and their use as UV absorbers, especially in photographic materials, in inks, including inkjet inks and printing inks, in transfer prints, in paints and varnishes, organic polymeric materials, plastics, rubber, glass, packaging materials, in sunscreens of cosmetic preparations and in skin protection compositions.Type: GrantFiled: November 8, 2001Date of Patent: November 25, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Vien Van Toan, Andreas Valet, Pascal Hayoz
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Patent number: 6649770Abstract: Compounds of formula I or II where R is an aryl moiety, such as phenyl, naphthyl or biphenylyl, or is phenyl substituted by one or more trifluoromethyl, bromo or cyano, and E1 and E2 are independently hydrogen, alkyl, aralkyl and the like are prepared by reaction of a benzotriazole substituted on the 5-position of the benzo ring by a halogen atom with a arylboronic acid or ester in the presence of a transition-metal catalyst, such as palladium (II) diacetate. The benzotriazole compounds of formula I are particularly efficacious as stabilizers for automotive coatings and candle wax.Type: GrantFiled: November 27, 2000Date of Patent: November 18, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Stephen D. Pastor, Andrew B. Naughton, Robert Detlefsen, Mervin G. Wood, Joseph Suhadolnik, Anthony DeBellis, Deborah DeHessa
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Publication number: 20030176704Abstract: The present invention relates to a photo-stabilizer of the general formula (I): 1Type: ApplicationFiled: May 16, 2003Publication date: September 18, 2003Inventors: Shroj Al Mohitkumar Desai, Raj Pal Singh
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Patent number: 6610856Abstract: The present invention relates to a photo-stabilizer of the general formula (I): wherein R1 is hydrogen, halogen, C1 to C12 alkyl, alkoxy (linear and branched), R2 is hydrogen, C1-C8 alkyl, cyclopentyl, cyclohexyl or cumyl, R3 is hydrogen, C1-C4 alkyl, R4 is methyl or ethyl, R5 is C1-C8 alkyl, alkyl phenyl, alkoxy, acyl, cycloalkyl and allyl, X is O, NH, C1-C8 alkyloxy and alkylamino (linear or branched), to derivatives and intermediates thereof.Type: GrantFiled: July 25, 2002Date of Patent: August 26, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Shroj Al Mohitkumar Desai, Raj Pal Singh
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Patent number: 6605727Abstract: Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzo ring, for example a trifluoromethyl group, which involves diazotizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.Type: GrantFiled: December 10, 2002Date of Patent: August 12, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin G. Wood, Deborah DeHessa, Joseph Suhadolnik, Andrew B. Naughton, Jerome Sanders, Jacqueline Lau, Rong Xiong, Joseph Babiarz
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Publication number: 20030130524Abstract: Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzo ring, for example a trifluoromethyl group, which involves diazotizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.Type: ApplicationFiled: December 10, 2002Publication date: July 10, 2003Inventors: Mervin G. Wood, Deborah DeHessa, Joseph Suhadolnik, Andrew B. Naughton, Jerome Sanders, Jacqueline Lau, Rong Xiong, Joseph Babiarz
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Publication number: 20030120083Abstract: Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzo ring, for example a trifluoromethyl group, which involves diazotizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.Type: ApplicationFiled: December 10, 2002Publication date: June 26, 2003Inventors: Mervin G. Wood, Deborah DeHessa, Joseph Suhadolnik, Andrew B. Naughton, Jerome Sanders, Jacqueline Lau, Rong Xiong, Joseph Babiarz
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Publication number: 20030092913Abstract: The present invention relates to a photo-stabilizer of the general formula (I): 1Type: ApplicationFiled: July 25, 2002Publication date: May 15, 2003Inventors: Shroj Almohitkumar Desai, Raj Pal Singh
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Patent number: 6559311Abstract: The present invention relates to a process for the preparation of a photo-stabilizer of the general formula (I): wherein R1 is hydrogen, halogen, C1 to C12 alkyl, alkoxy (linear and branched), R2 is hydrogen, C1-C8 alkyl, cyclopentyl, cyclohexyl or cumyl, R3 is hydrogen, C1-C4 alkyl, R4 is methyl or ethyl, R5 is C1-C8 alkyl, alkyl phenyl, alkoxy, acyl, cycloalkyl and allyl, X is O, NH, C1-C8 alkyloxy and alkylamino (linear or branched), and derivatives and intermediates thereof.Type: GrantFiled: October 30, 2001Date of Patent: May 6, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Shroj Al Mohitkumar Desai, Raj Pal Singh
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Patent number: 6559316Abstract: This invention provides a method for preparing 2-(2-hydroxyphenyl)-2H-benzotriatzole of formula (I) below, consisting of steps of: a) performing a first reduction in which hydrazine hydrate is added to a compound of formula (II) below with or without a phase transition catalyst in the presence of solvents which include a nonpolar solvent, water, and an alkaline compound, thereby preparing a compound of formula (III) below; and b) performing a second reduction in which water is added to the compound of formula (III) prepared in step a), and then zinc powder and sulfuric acid are added thereto with or without the phase transition catalyst, wherein, X is halogen or hydrogen; R is hydrogen, C1-C12 alkyl, C5-C8 cycloalkyl, phenyl, or phelyl-C1-C4 alkyl; and R′ is C1-C12 alkyl, C5-C8 cycloalkyl, phenyl, or phenyl-C1-C4 alkyl.Type: GrantFiled: September 5, 2002Date of Patent: May 6, 2003Assignee: LG Chem, Ltd.Inventors: Jeong-Kyu Kim, Chul-Hwan Choi
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Patent number: 6548678Abstract: Disclosed is a method for producing 5-phenoxycarbonylbenzotriazole (I): by reacting 1H-benzotriazole-5-carboxylic acid (II): with diphenyl carbonate (III):Type: GrantFiled: September 24, 2002Date of Patent: April 15, 2003Assignee: Sumitomo Chemical Company, LimitedInventors: Keiko Yamamoto, Takashi Kamikawa