Bicyclo Ring System Having The Diazole Ring As One Of The Cyclos Patents (Class 548/302.7)
At least three ring hetero atoms in the bicyclo ring system (e.g., furo- imidazole, (1,2-a) imidazole, pyrazo (1,2-a) imidazolidine, etc.) (Class 548/303.1)
The other ring is a benzene ring (Class 548/304.4)
  • Ligands for pnicogen chelate complexes with a metal of subgroup VIII and use of the complexes as catalysts for hydroformylation, carbonylation, hydrocyanation or hydrogenation
    Publication number: 20040110960
    Abstract: Pnicogen chelate compounds which have two pnicogen-containing groups joined to one another via a xanthene-like or triptycene-like molecular skeleton and in which at least one pyrrole group is covalently bound via its nitrogen atom to each pnicogen atom form complexes with metals of transition group VIII which are useful as catalysts for the hydroformylation of olefins.
    Type: Application
    Filed: September 29, 2003
    Publication date: June 10, 2004
    Inventors: Wolfgang Ahlers, Rocco Paciello, Dieter Vogt, Peter Hofmann
  • Hydantoin compounds useful as anti-inflammatory agents
    Patent number: 6710064
    Abstract: Compounds having the formula (I): and pharmaceutically-acceptable salts thereof, are useful for treating inflammatory or immune diseases, in which A is a four to seven membered heterocyclic or carbocyclic saturated ring; L and K are O or S; M is N or CH; Y is N or CH; Z is hydrogen, alkyl or substituted alkyl; and R1-R4 are as defined in the specification.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: March 23, 2004
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, T. G. Murali Dhar, Edwin J. Iwanowicz
  • Sulfamides as gamma-secretase inhibitors
    Publication number: 20040049038
    Abstract: Novel sulfamides of formula (1) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: May 1, 2003
    Publication date: March 11, 2004
    Inventors: Ian James Collins, Joanne Claire Hanam, Timothy Harrison, Stephen John Lewis, Andrew Madin, Timothy Jason Sparey, Brian John Williams
  • Cyclic aminothioureas as additives for lubricating oils
    Publication number: 20040029746
    Abstract: A composition comprising: (a) from 0.
    Type: Application
    Filed: August 7, 2003
    Publication date: February 12, 2004
    Inventor: Ravindranath Mukkamala
  • Small molecules useful in the treatment of inflammatory disease
    Patent number: 6689804
    Abstract: A method for treating inflammatory and immune cell-mediated diseases by the administration of compounds of the formula I Exemplary are:
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: February 10, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jiang-Ping Wu, Terence Alfred Kelly, Rene Lemieux, Daniel R. Goldberg, Jonathan Emilian Emeigh, Ronald John Sorcek
  • Bicyclic imidazo-5-yl-amine derivatives
    Publication number: 20040023927
    Abstract: A novel bicyclic imidazo-5-yl-amine derivative of Formula I, 1
    Type: Application
    Filed: August 5, 2003
    Publication date: February 5, 2004
    Applicant: Gruenenthal GmbH
    Inventors: Matthias Gerlach, Corinna Maul
  • Bicyclic modulators of androgen receptor function
    Patent number: 6670386
    Abstract: The invention provides compounds of the formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: December 30, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chongqing Sun, Jeffrey A. Robl, Mark E. Salvati, Tammy Wang, Lawrence Hamann, David Augeri
  • Small molecules useful for the treatment of inflammatory disease
    Publication number: 20030232817
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: February 24, 2003
    Publication date: December 18, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventor: Roman Wolfgang Fleck
  • Pharmaceuticals for neurogenic pain
    Patent number: 6664283
    Abstract: This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: December 16, 2003
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Masamichi Okada, Yukinori Nagakura, Tetsuo Kiso, Takashi Toya, Satoshi Hayashibe
  • Imidazo heterocyclic compounds
    Patent number: 6610721
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: August 26, 2003
    Assignee: Novo Nordisk A/S
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald
  • Cyclic somatostatin analogs
    Patent number: 6602849
    Abstract: The present invention is directed to cyclic derivatives containing an imidazole cis amide bond mimetic which bind selectively to somatostatin receptor subtypes and the use thereof in treating conditions which can be treated by eliciting an agonist or antagonist effect from the somatostatin subtype receptors. This invention is also directed to methods for making the compounds of the instant invention.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: August 5, 2003
    Assignee: Societe de Conseils de Recherche et d'Applications Scientifiques, S.A.S.
    Inventor: Thomas D. Gordon
  • Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines
    Publication number: 20030119842
    Abstract: Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: 1
    Type: Application
    Filed: October 18, 2002
    Publication date: June 26, 2003
    Applicant: GRUENENTHAL GmbH.
    Inventors: Matthias Gerlach, Corinna Sundermann
  • CAK inhibitors and uses thereof
    Publication number: 20030119793
    Abstract: The present invention relates to compounds useful as inhibitors of CAK, compositions thereof. The present invention also relates to methods using the compositions for treating CAK-mediated diseases, such as fungal infections.
    Type: Application
    Filed: June 6, 2002
    Publication date: June 26, 2003
    Inventors: Brian Ledford, Cameron Stuver Moody, Michael Mullican, Mark Namchuk
  • Bridged bicyclic serine protease inhibitors
    Publication number: 20030119752
    Abstract: The present invention relates to peptidomimetic compounds which inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The compounds of this invention have a bridged bicyclic moiety at the P2 position. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.
    Type: Application
    Filed: July 11, 2002
    Publication date: June 26, 2003
    Inventors: Luc J. Farmer, Janos Pitlik, Robert B. Perni, Lawrence F. Courtney, John van Drie
  • Immunotherapeutic agents
    Patent number: 6518281
    Abstract: Novel amides and imides are inhibitors of tumor necrosis factor&agr; and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: February 11, 2003
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Mary Shire
  • Small molecules useful in the treatment of inflammatory disease
    Patent number: 6492408
    Abstract: Compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases.
    Type: Grant
    Filed: June 27, 2000
    Date of Patent: December 10, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jiang-Ping Wu, Terence Alfred Kelly, Rene Lemieux, Daniel R. Goldberg, Jonathan Emilian Emeigh, Ronald John Sorcek
  • Angiogenesis inhibitors
    Patent number: 6465484
    Abstract: The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tryrosine kinase-dependent diseases/conditions such as angiogenenesis, cancer, atherosclerosis, diabetic retinopathy or autoimmune diseases, in mammals.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: October 15, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Mark T. Bilodeau, Randall W. Hungate, April M. Cunningham, Timothy J. Koester
  • Heterocyclic compounds, materials for light emitting devices and light emitting devices using the same
    Patent number: 6461747
    Abstract: Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): L&Parenopenst;A)m  (I) wherein A represents a heterocyclic group in which two or more aromatic heterocycles are condensed; m represents an integer of 2 or more, and the heterocyclic groups represented by A may be the same or different; and L represents a connecting group.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: October 8, 2002
    Assignee: Fuji Photo Co., Ltd.
    Inventors: Hisashi Okada, Toshihiro Ise
  • Hydantoin compounds useful as anti-inflammatory agents
    Publication number: 20020143035
    Abstract: Compounds having the formula (I): 1
    Type: Application
    Filed: November 30, 2001
    Publication date: October 3, 2002
    Inventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, T.G. Murali Dhar, Edwin J. Iwanowicz
  • Imidazole compounds
    Patent number: 6437147
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: August 20, 2002
    Assignees: Novo Nordisk, Boehringer Ingelheim International GmbH
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald, Bernd Peschke, Ulla Grove Sidelmann, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Muller, Bernd Krist, Birgitte Eriksen
  • Quinone derivatives
    Patent number: 6433199
    Abstract: The invention relates to a quinone derivative of the following formula: which is capable of converting into two alkylating agents upon bioreduction. Substituents A, B, C, and D are as described herein.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: August 13, 2002
    Assignee: Shionogi BioResearch Corporation
    Inventors: Mitsunori Ono, Keizo Koya, Lijun Sun, Yumiko Wada, Wojciech Wrona, Natalie Dales, Xueliang Tao, Sylvia Holden
  • Process for the synthesis of an endothelin receptor antagonist
    Publication number: 20020107391
    Abstract: The present invention relates to a practical and efficient way to synthesize the compound for the endothelin receptor antagonist involving a Grignard addition and a cyclization reaction to give a desired compound of the general formula shown below: 1
    Type: Application
    Filed: October 18, 2001
    Publication date: August 8, 2002
    Inventors: Lisa F. Frey, Cheng Y. Chen, Jing Li, Zhiguo J. Song, Lushi Tan, Richard D. Tillyer, David M. Tschaen, Matthew M. Zhao
  • Bicyclic amine derivatives
    Publication number: 20020061913
    Abstract: The present invention provides compounds of formula (I): 1
    Type: Application
    Filed: June 22, 2001
    Publication date: May 23, 2002
    Inventors: Christopher John Urch, Terence Lewis, Raymond Leo Sunley, Roger Salmon, Christopher Richard Ayles Godfrey, Christopher Ian Brightwell, Matthew Brian Hotson
  • Hydantoin derivative compounds, pharmace utical compositions, and methods of using same
    Publication number: 20020058685
    Abstract: The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating neurological disorders, including physically damaged nerves and neurodegenerative diseases; for treating alopecia and promoting hair growth; for treating vision disorders and/or improving vision; for treating memory impairment and/or enhancing memory performance; and for treating sensorineural hearing loss by administering such compounds.
    Type: Application
    Filed: December 21, 2000
    Publication date: May 16, 2002
    Inventor: Gregory S. Hamilton
  • Inhibitors of prenyl-protein transferase
    Patent number: 6380228
    Abstract: The present invention is directed to peptidomimetic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: April 30, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Craig A. Stump, Theresa M. Williams
  • Small molecules useful in the treatment of inflammatory disease
    Patent number: 6365615
    Abstract: Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 2-(3,5-Dichlorophenyl)-7-(R*)-phenyl-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; 2-(3,5-Dichlorophenyl)-7a-(R*)-methyl-7-(R*)-phenyl-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; and, 7-(R*)-(4-Bromophenyl)-2-(3,5-dichlorophenyl)-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: April 2, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Terence Alfred Kelly, Jiang-Ping Wu, Daniel Kuzmich
  • Substituted phenylheterocyclic herbicides
    Patent number: 6358885
    Abstract: This invention relates to certain phenylheterocyclic compounds, herbicidal compositions thereof and a method for their use as general and selective preemergent or postemergent herbicides or plant growth regulants.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: March 19, 2002
    Assignees: Mississippi State University, Research Technology Corporation Mississippi State
    Inventors: Thomas P. Selby, Thomas M. Stevenson
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
    Patent number: 6358980
    Abstract: Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: March 19, 2002
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, James M. Chen, Arie Zask, Vincent P. Sandanayaka, Mila T. Du, Jannie L. Baker
  • Bicyclic amidines, process for their preparation, and their use as catalyst
    Publication number: 20020028939
    Abstract: The process for the preparation of bicyclic amidines of the general formula: 1
    Type: Application
    Filed: May 24, 2001
    Publication date: March 7, 2002
    Inventors: Oleg Werbitzky, Ulrich Daum, Rachel Bregy
  • Methoxymino-phenylacetamide derivatives and their utilization as pesticides
    Patent number: 6350909
    Abstract: The invention relates to new imides, to a plurality of processes for their preparation and to their use as fungicides.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: February 26, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Heinemann, Herbert Gayer, Peter Gerdes, Martin Vaupel, Astrid Mauler-Machnik, Gerd Hänssler, Klaus Stenzel, Martin Kugler, Thomas Jaetsch, Peter Wachtler
  • p38 map kinase inhibitors
    Publication number: 20020013354
    Abstract: The present invention relates to compounds of Formula (I) 1
    Type: Application
    Filed: April 19, 2001
    Publication date: January 31, 2002
    Inventors: Soan Cheng, David Michael Goldstein, Teresa Alejandra Trejo Martin, Eric Brian Sjogren
  • Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same
    Patent number: 6339082
    Abstract: A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically acceptable acids and bases useful for treating loss of bone matrix.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: January 15, 2002
    Assignees: Aventis Pharma S.A., Genetech, Inc.
    Inventors: Denis Carniato, Thomas R. Gadek, Jean-Francois Gourvest, Jochen Knolle, Robert S. McDowell, Anurschirwan Peyman
  • Method for preparing cycloheptimidazoles
    Patent number: 6316634
    Abstract: A method for preparation of a cycloheptimidazole compound having formula (5), wherein: R4 is a lower alkyl group, comprising reacting a compound of formula (1), with an alkylamidine hydrochloride.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: November 13, 2001
    Assignee: Kotobuki Pharmaceutical Co Ltd
    Inventors: Tsuyoshi Tomiyama, Akira Tomiyama, Naoto Ueyama, Akira Ohno
  • Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
    Patent number: 6297260
    Abstract: The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: October 2, 2001
    Assignee: NitroMed, Inc.
    Inventors: Upul K. Bandarage, Qing Dong, Xinqin Fang, David S. Garvey, Gregory J. Mercer, Stewart K. Richardson, Joseph D. Schroeder, Tiansheng Wang
  • Hydrazono-benzazulene derivatives, pharmaceutical compositions and intermediates
    Patent number: 6277845
    Abstract: Compounds of the formula wherein the substituents are as defined in the application and their pharmaceutically acceptable acid and base salts thereof which are useful for preventing loss of bone matrix.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: August 21, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Denis Carniato, Thomas R. Gadek, Francois Goubet, Jean-Francois Gourvest, Jochen Knolle, Robert S. McDowell, Karl-Heinz Scheunemann
  • Method for preparing cycloheptimidazoles
    Publication number: 20010008944
    Abstract: The present invention relates to novel compounds of formula(1).
    Type: Application
    Filed: March 14, 2001
    Publication date: July 19, 2001
    Inventors: Tsuyoshi Tomiyama, Akira Tomiyama, Naoto Ueyama, Akira Ohno