Having -c(=x)-, Wherein X Is Chalcogen Bonded Directly To The Diazole Ring Patents (Class 548/369.4)
  • Publication number: 20150031536
    Abstract: The invention relates to sulfmimidoyl- and sulfonimidoylbenzoyl derivatives of the general formula (I). In said formula (I), R, R?, X, W and Z represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogens. Q represents a cyclohexandionyl-, pyrazolyl-oder isoxazolyl radical.
    Type: Application
    Filed: February 18, 2013
    Publication date: January 29, 2015
    Inventors: Hartmut Ahrens, Simon Doerner-Rieping, Stefan Lehr, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler
  • Patent number: 8901315
    Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: December 2, 2014
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Hidekazu Inoue, Hidenobu Murafuji, Yasuhiro Hayashi
  • Patent number: 8883689
    Abstract: A herbicide composition includes a fenoxaprop ester and a weak acid buffer system. The buffer system maintains the herbicidal composition at a pH in the range of 4 to 8. In one non-limiting embodiment, the fenoxaprop ester is fenoxaprop ethyl. The buffer system can include an amine-containing material, such as a tertiary amine. The herbicide composition can include other herbicides, such as weak acid herbicides, for example pyrasulfotole, bromoxynil, and/or bromoxynil esters and can include one or more safeners.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: November 11, 2014
    Assignee: Bayer CropScience LP
    Inventors: Tai-Teh Wu, Karen L. Eagles
  • Publication number: 20140235446
    Abstract: The compounds of the formula (I) in which L represents a radical of the formula and A1, B1 and A2 and B2 are as defined in Claim 1, are suitable as herbicides for the control of harmful plants or as plant growth regulators. The compounds can be prepared by the process of Claim 12.
    Type: Application
    Filed: July 11, 2012
    Publication date: August 21, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Marc Mosrin, Harald Jakobi, Alfred Angermann, Elmar Gatzweiler, Isolde Häuser-Hahn, Ines Heinemann, Christopher Hugh Rosinger, Stefan Lehr, Stefan Schnatterer
  • Patent number: 8802713
    Abstract: To provide pesticides such as insecticides, miticides and nematicides, which are excellent in the safety, pesticidal effects, residual effectiveness, etc., which further have infiltration, and which can be applied by soil treatment. A pesticide comprising a 3-alkoxy-1-phenyl-pyrazole derivative represented by the formula [I] or an agriculturally acceptable salt thereof as an active ingredient: wherein, for example, R1 is a C1-C10 alkyl group or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or the like, and each of R4, R5, R6 and R8 which are independent of one another, is a hydrogen atom or the like, and R7 is a C2-C4 haloalkylthio group or the like.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: August 12, 2014
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Satoru Ohata, Katsuya Kato, Keiji Toriyabe, Yoshihiro Ito, Ryuji Hamaguchi, Yuki Nakano
  • Publication number: 20140213449
    Abstract: The present invention is directed to the discovery, isolation, identification and methods of synthesis of a novel chemical complex that can be used to stabilize mixtures of different chemical compounds, and in particular mixtures of different herbicidal compounds.
    Type: Application
    Filed: December 13, 2013
    Publication date: July 31, 2014
    Applicant: BAYER CROPSCIENCE LP
    Inventors: Tai-Teh WU, Karen L. EAGLES, Michael W. EDENFIELD
  • Publication number: 20140073799
    Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].
    Type: Application
    Filed: August 29, 2013
    Publication date: March 13, 2014
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Hidekazu INOUE, Hidenobu Murafuji, Yasuhiro Hayashi
  • Publication number: 20140012013
    Abstract: Disclosed is a process for producing a pyrazole carboxylic acid derivative which is useful as a significant intermediate of an 11?HSD-1 inhibitor. A compound represented by the Formula (XI): is useful as a significant intermediate of an 11?HSD-1 inhibitor, wherein R1 and R2 are each independently hydrogen or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl and R4 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl.
    Type: Application
    Filed: March 15, 2012
    Publication date: January 9, 2014
    Applicant: SHIONOGI & CO., LTD.
    Inventors: Masaaki Uenaka, Shuji Yonezawa, Akira Iida, Mutsumi Takaki, Tomoyuki Ogawa, Satoshi Goda, Yoshikatsu Hirose, Tomohiro Fukuda
  • Patent number: 8598078
    Abstract: Compounds of Formula I wherein the substituents are as defined in Claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as agrochemical active ingredients and can be prepared in a manner known per se.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: December 3, 2013
    Assignee: Syngenta Crop Protection, LLC
    Inventors: Olivier Loiseleur, Roger Graham Hall, André Denis Stoller, Gerald Wayne Craig, André Jeanguenat, Andrew Edmunds
  • Patent number: 8536097
    Abstract: A description is given of 4-(4-haloalkyl-3-thiobenzoyl)pyrazoles of the formula (I) and of their use as herbicides. In this formula (I), X, Y, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: September 17, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Elmar Gatzweiler, Isolde Haeuser-Hahn, Christopher Hugh Rosinger
  • Publication number: 20130143879
    Abstract: The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).
    Type: Application
    Filed: January 31, 2013
    Publication date: June 6, 2013
    Applicant: GENKYOTEX SA
    Inventor: Genkyotex Sa
  • Patent number: 8329880
    Abstract: The invention relates to a process for preparing naphthalen-2-yl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: December 11, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Jordi Corbera Arjona, Maria Rosa Cuberes-Altisent
  • Patent number: 8288319
    Abstract: 4-(3-Alkylthiobenzoyl)pyrazoles of the formula (I) are described as herbicides. In this formula (I), X, Y, R1, R2, R3 and R4 represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: October 16, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Andreas Almsick, Jan Dittgen, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Stefan Lehr, Dieter Feucht
  • Patent number: 8282721
    Abstract: An arylidene-pyrazolone dye of the following formula (1): wherein R1, R2, R3, R4 and R5 each independently represent a monovalent substituent; n indicates an integer of from 0 to 4; when n is 2 or more, plural R3's may be the same or different; and R1 and R2 may bond to each other to form a cyclic structure.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: October 9, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Yoshihiko Fujie, Shinichi Ichikawa, Takashi Hoshimiya, Hisashi Mikoshiba, Naotsugu Muro
  • Publication number: 20120165540
    Abstract: A process is described for the preparation of 3-alkylsulfinylbenzoyl derivatives of the formula (IIIa) by reaction of 3-alkylsulfinylbenzoic acids of the formula (Ib) with compounds of the formula (II) in the presence of a chlorinating agent and a base. In the formulae specified above, Y is a radical such as pyrazolyl and cyclohexanedionyl. R1, R2 and R3 are radicals such as halogen, nitro, cyano and alkyl.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 28, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Mark James FORD, Jan Peter SCHMIDT, Helmut KOHLHEPP
  • Patent number: 8178695
    Abstract: What is described are 4-(3-aminobenzoyl)-1,3-dimethylpyrazoles of the general formula (I) and their use as herbicides. In this general formula (I), R1 and R2 are radicals such as hydrogen and organic radicals, such as alkyl, alkenyl and alkynyl. Y is hydrogen or a protective group, such as tosyl.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: May 15, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Ines Heinemann, Andreas van Almsick, Lothar Willms, Monika Schmitt, Jan Dittgen, Martin Hills, Heinz Kehne, Christopher Rosinger, Dieter Feucht
  • Patent number: 8119569
    Abstract: The present invention provides a novel herbicide showing excellent herbicidal effects, which has a wide application range including agricultural fields and non-agricultural fields and various application methods including soil treatment and foliage treatment. A benzoylpyrazole compound represented by the formula (I) or its salt: wherein R1 is alkyl, R2 is a hydrogen atom or alkyl, R3 is alkyl, R4 is alkyl or halogen, R5 is alkyl substituted by one Y1, haloalkoxy, alkoxy substituted by one Y2, or alkoxycarbonyl, R6 is alkylsulfonyl, A is alkylene substituted by at least one alkyl, Y1 is alkoxy or haloalkoxy, and Y2 is alkoxy; a process for its production; a herbicide containing it as an active ingredient; and a method for controlling undesired plants or inhibiting their growth, which comprises applying a herbicidally effective amount thereof to the undesired plants or to a place where they grow.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: February 21, 2012
    Assignee: Ishihara Sangyo Kaisha, Ltd.
    Inventors: Terumasa Komyoji, Masamitsu Tsukamoto, Hiroshi Kikugawa, Hiroshi Hata
  • Patent number: 8114816
    Abstract: 4-(3-Alkylsulfinylbenzoyl)pyrazoles of the formula (I) are described as herbicides. In this formula (I), R1 to R4, X and Y are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: February 14, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Andreas Almsick, Jan Dittgen, Simon Dörner, Dieter Feucht, Isolde Häuser-Hahn, Stefan Lehr, Christopher Hugh Rosinger
  • Publication number: 20120028800
    Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: January 25, 2010
    Publication date: February 2, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20120029192
    Abstract: This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).
    Type: Application
    Filed: October 7, 2011
    Publication date: February 2, 2012
    Inventors: Lyn Howard Jones, Charles Eric Mowbray, David Anthony Price, Matthew Duncan Selby, Paul Anthony Stupple
  • Publication number: 20120021903
    Abstract: A description is given of 4-(4-haloalkyl-3-thiobenzoyl)pyrazoles of the formula (I) and of their use as herbicides. In this formula (I), X, Y, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl.
    Type: Application
    Filed: July 20, 2011
    Publication date: January 26, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: HARTMUT AHRENS, ELMAR GATZWEILER, ISOLDE HÄEUSER-HAHN, CHRISTOPHER HUGH ROSINGER
  • Patent number: 8084398
    Abstract: Benzoylpyrazoles represented by the following formula (I), and use thereof as herbicides. R1 represents alkyl; R2 represents alkyl or cycloalkyl; R3 represents hydrogen, alkyl, alkenyl, alkynyl, aralkyl, alkylsulfonyl, optionally substituted phenylsulfonyl, acyl or acylalkyl; X represents halogen or alkyl; Y represents halogen; n represents 2 or 3, and T represents the above group T1 or T2, wherein R4 represents hydrogen, alkyl, alkoxy or alkylthio.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: December 27, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Shinichi Narabu, Yasushi Yoneta, Akihiko Yanagi, Shinichi Shirakura, Seiji Ukawa, Teruyuki Ichihara, Shin Nakamura, Martin Hills, Heinz Kehne, Jan Dittgen, Dieter Feucht, Christopher Rosinger
  • Publication number: 20110282070
    Abstract: A benzoylpyrazole compound represented by the formula (I) or its salt: wherein R1 is alkyl or cycloalkyl, R2 is a hydrogen atom or alkyl, R3 is alkyl; cycloalkyl; haloalkyl; alkoxyalkyl; alkoxycarbonylalkyl; alkenyl; or arylalkyl which may be substituted by R8, R4 is alkyl; haloalkyl; alkoxy; halogen; nitro; cyano; alkylthio; alkylsulfinyl; or alkylsulfonyl, R5 is a hydrogen atom; alkyl; alkenyl; alkynyl; halogen; cyano; cyanoalkyl; cyanoalkeny; haloalkyl; alkoxyalkyl; haloalkoxyalkyl; amino(thiocarbonyl)alkyl which may be substituted by at least one substituent selected from alkyl, cyano, is cyanoalkyl, (alkylthio)carbonylalkyl, alkyl(thiocarbonyl)alkyl, —C(O)OR7 and —C(O)SR7; thiocyanatoalkyl; alkoxy; alkenyloxy; alkynyloxy; haloalkoxy; alkoxyalkoxy; haloalkoxyalkoxy; alkoxyhaloalkoxy; haloalkoxyhaloalkoxy; alkoxyalkoxyalkyl; alkylthio; alkoxyalkylthio; haloalkoxyalkylthio; alkoxyhaloalkylthio; haloalkoxyhaloalkylthio; alkylthioalkylthio; haloalkylthioalkylthio; alkylthiohaloalkylthio; haloalkylthiohalo
    Type: Application
    Filed: July 21, 2011
    Publication date: November 17, 2011
    Applicant: ISHIHARA SANGYO KAISHA, LTD.
    Inventors: Hiroshi SHIMOHARADA, Masamitsu Tsukamoto, Masahiko Ikeguchi, Hiroshi Kikugawa, Makiko Sano, Yoshinori Kitahara, Hidemasa Kominami, Tatsuya Okita
  • Publication number: 20110269757
    Abstract: The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).
    Type: Application
    Filed: September 22, 2009
    Publication date: November 3, 2011
    Applicant: GENKYOTEX SA
    Inventors: Patrick Page, Mike Orchard, Benoit Laleu, Francesca Gaggini
  • Patent number: 8039640
    Abstract: The invention relates to new morphine compounds of the formula: where R1 represents a C1-6 alkyl radical and the radicals R2 and R3 are independently selected from the group consisting of hydrogen atoms, methyl groups and acetyl groups.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: October 18, 2011
    Assignee: Universitätsklinikum Freiburg
    Inventor: Rainer Trittler
  • Publication number: 20110178081
    Abstract: The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).
    Type: Application
    Filed: September 22, 2009
    Publication date: July 21, 2011
    Applicant: Genkyotex SA
    Inventors: Patrick Page, Mike Orchard, Benoit Laleu, Francesca Gaggini
  • Publication number: 20110166343
    Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].
    Type: Application
    Filed: March 14, 2011
    Publication date: July 7, 2011
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Hidekazu Inoue, Hidenobu Murafuji, Yasuhiro Hayashi
  • Publication number: 20110144345
    Abstract: The benzoyl derivative of the present invention is represented by formula (I) (in the formula, E represents an alkoxy group, an alkoxycarbonyl group or the like, R1 represents a halogen atom, an organic group or the like, p represents an integer of 0 to 3, R2 and R3 each independently represents an alkyl group or the like, Q represents a group selected from the groups represented by the following formulas Q1 to Q8: (in the formula, * represents binding site, G represents oxygen atom or the like), R4 to R5, R8 to R13 represents hydrogen atom, an alkyl group or the like), R6 represents cyano group or the like, X represents —C(R12)(R13)— or —N(R12)—, Y represents oxo group, an alkyl group or the like, m represents an integer of 0 to 4)) or salt thereof.
    Type: Application
    Filed: August 3, 2009
    Publication date: June 16, 2011
    Applicant: NIPPON SODA CO., LTD.
    Inventors: Tetsuo Tamai, Kazuaki Tsukuda, Shigeo Yamada, Yasuhiro Miyashita, Shingo Hirai
  • Patent number: 7943551
    Abstract: What is described are 3-cyclopropyl-4-(3-thiobenzoyl)pyrazoles of the general formula (I) and their use as herbicides In this formula (I), R1, R2, R3, X and Y are radicals such as hydrogen and organic radicals, such as alkyl. R4 is hydrogen or a protective group, such as tosyl.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: May 17, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Andreas van Almsick, Stefan Lehr, Monika Schmitt, Jan Dittgen, Dieter Feucht, Martin Hills, Heinz Kehne, Christopher Rosinger
  • Patent number: 7943550
    Abstract: What is described are 4-(3-aminobenzoyl)pyrazoles of the general formula (I) and their use as herbicides. In this formula (I), R1 and R2 are radicals such as hydrogen and organic radicals, such as alkyl, alkenyl and alkynyl. Y is hydrogen or a protective group, such as tosyl.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: May 17, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Ines Heinemann, Andreas van Almsick, Lothar Willms, Monika Schmitt, Jan Dittgen, Martin Hills, Heinz Kehne, Christopher Rosinger, Dieter Feucht
  • Patent number: 7939467
    Abstract: What is described are 4-(3-aminobenzoyI)-1-ethylpyrazoles of the general formula (I) and their use as herbicides. In this general formula (I), R1 and R2 are radicals such as hydrogen and organic radicals, such as alkyl, alkenyl and alkynyl. Y is hydrogen or a protective group, such as tosyl.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: May 10, 2011
    Assignee: Bayer CropScience AG
    Inventors: Ines Heinemann, Andreas van Almsick, Lothar Willms, Monika Schmitt, Jan Dittgen, Martin Hills, Heinz Kehne, Christopher Rosinger, Dieter Feucht
  • Patent number: 7932211
    Abstract: What is described are 4-(4-trifluoromethyl-3-thiobenzoyl)pyrazoles of the general formula (I) and their use as herbicides. In this formula (I), R1, R2, R3 and R4 are radicals such as hydrogen and organic radicals, such as alkyl. Y is hydrogen or a protective group, such as tosyl.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: April 26, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Andreas van Almsick, Monika Schmitt, Jan Dittgen, Martin Hills, Heinz Kehne, Christopher Rosinger, Stefan Lehr, Dieter Feucht
  • Publication number: 20110045980
    Abstract: 4-(3-Alkylthiobenzoyl)pyrazoles of the formula (I) are described as herbicides. In this formula (I), X, Y, R1, R2, R3 and R4 represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
    Type: Application
    Filed: July 27, 2010
    Publication date: February 24, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Hartmut Ahrens, Andreas Almsick, Jan Dittgen, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Stefan Lehr, Dieter Feucht
  • Publication number: 20100317528
    Abstract: To provide a novel herbicide which has a wide range of applications to agricultural or non-agricultural fields and various methods for application such as soil treatment and foliage treatment and which exhibits excellent herbicidal effects. A herbicide containing a benzoylpyrazole compound represented by the formula (I) or its salt, as an active ingredient: wherein R1 is alkyl or cycloalkyl, R2 is a hydrogen atom or alkyl, R3 is hydroxy, R4 is alkyl, haloalkyl or the like, R5 is halogen, cyano, cyanoalkyl or the like, and R6 is haloalkyl, halogen or the like.
    Type: Application
    Filed: December 27, 2007
    Publication date: December 16, 2010
    Applicant: ISHIHARA SANGYO KAISHA, LTD.
    Inventors: Hiroshi Shimoharada, Masamitsu Tsukamoto, Masahiko Ikeguchi, Hiroshi Kikugawa, Souichiro Nagayama, Makiko Sano, Yoshinori Kitahara, Tatsuya Okita, Hiroshi Hata
  • Publication number: 20100305095
    Abstract: The present invention relates to, inter alia, the use of a compound capable of inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD) in an animal in the manufacture of a medicament for use in the treatment and/or prevention of depression. The invention also provides for the use of a compound capable of inhibiting HPPD in an animal in the manufacture of a medicament for use in the treatment of the withdrawal symptoms associated with an addictive drug which causes dopamine dependant associative learning disorders in said animal. In a particular embodiment said HPPD inhibitor is selected from the group consisting of the compound depicted as compound 1; 2; and 3.22.
    Type: Application
    Filed: August 18, 2006
    Publication date: December 2, 2010
    Inventors: Kim Zachary Travis, John Posner
  • Patent number: 7834186
    Abstract: A method is disclosed for preparing a 2-substituted-5-oxo-3-pyrazolidinecarboxylate compound of Formula I The method comprises contacting a succinic acid derivative of the formula R1OC(O)C(H)(X)C(R2a)(R2b)C(O)Y (i.e. Formula II) wherein X and Y are leaving groups and L, R1, R2a and R2b are as defined in the disclosure, with a substituted hydrazine of the formula LNHNH2 (i.e. Formula III) in the presence of a suitable acid scavenger and solvent. Also disclosed is the preparation of compounds of Formula IV wherein X1, R6, R7, R8a, R8b, R9, and n are as defined in the disclosure. Also disclosed is a composition comprising on a weight basis about 20 to 99% of the compound of Formula II wherein R1, R2a, R2b, R3, R4 and R5 are as defined in the disclosure; X is Cl, Br or I; and Y is F, Cl, Br or I; provided that when R2a and R2b are each H, and X and Y are each Cl then R1 is other than benzyl and when R2a and R2b are each phenyl, and X and Y are each Cl, then R1 is other than methyl or ethyl.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: November 16, 2010
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Gary David Annis
  • Patent number: 7834012
    Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: November 16, 2010
    Assignee: Abbott Laboratories
    Inventors: Zhonghua Pei, Thomas von Geldern, David J. Madar, Xiaofeng Li, Fatima Basha, Hong Yong, Kenton L. Longenecker, Bradley J. Backes, Andrew S. Judd, Mathew M. Mulhern, Kent D. Stewart
  • Patent number: 7816361
    Abstract: Compounds of formula (IA) or (IB) are inhibitors of CD80 and useful in immunomodulation therapy: wherein Ar represents an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group having from 5 to 10 ring atoms; R1 and R2 independently represent H, or C1-C6 alkyl; R3 represents H; F; CI; Br, —NO2; —CN; C1-C6 alkyl optionally substituted by F or CI; or C1-C6 alkoxy optionally substituted by F; R4 represents a carboxylic acid group (—COOH) or an ester thereof, or —C(?O)NR6R7, —NR7C(?O)R6, —NR7C(?O)OR6, —NHC(?O)NR7R6 or —NHC(?S)NR7R6 wherein R6 represents H, or a radical of formula -(Alk)m-Q wherein m is 0 or 1, Alk is an optionally substituted divalent straight or branched C1-C12 alkylene, or C2-C12 alkenylene, or C2-C12 alkynylene radical or a divalent C3-C12 carbocyclic radical, any of which radicals may be interrupted by one or more —O—, —S— or —N(R8)— radicals wherein R8 represents H or C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, or C3-C6 cycloalkyl, and Q represents H; —CF3; —OH; —SH; —
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: October 19, 2010
    Assignee: Medigene Limited
    Inventor: Ian Richard Matthews
  • Patent number: 7807703
    Abstract: The invention relates to novel aryl ketones of the formula (I) in which Z represents the groups and A1, A2, A3, R1, R2, R3, R4, R5, R6, R7, X, Y, and m are as defined in the disclosure, to their use as pesticides, in particular herbicides, and to processes and intermediates for their preparation.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: October 5, 2010
    Assignee: Bayer CropScience AG
    Inventors: Dorothee Hoischen, Stefan Herrmann, Kristian Kather, Klaus-Helmut Müller, Hans-Georg Schwarz, Otto Schallner, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Publication number: 20100210704
    Abstract: To provide pesticides such as insecticides, miticides and nematicides, which are excellent in the safety, pesticidal effects, residual effectiveness, etc., which further have infiltration, and which can be applied by soil treatment. A pesticide comprising a 3-alkoxy-1-phenyl-pyrazole derivative represented by the formula [I] or an agriculturally acceptable salt thereof as an active ingredient: wherein, for example, R1 is a C1-C10 alkyl group or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or the like, and each of R4, R5, R6 and R8 which are independent of one another, is a hydrogen atom or the like, and R7 is a C2-C4 haloalkylthio group or the like.
    Type: Application
    Filed: October 17, 2008
    Publication date: August 19, 2010
    Applicants: KUMIAI CHEMICAL INDUSTRY CO., LTD., IHARA CHEMICAL INDUSTRY CO., LTD.
    Inventors: Satoru Ohata, Katsuya Kato, Keiji Toriyabe, Yoshihiro Ito, Ryuji Hamaguchi, Yuki Nakano
  • Publication number: 20100094023
    Abstract: Benzoylpyrazoles represented by the following formula (I), and use thereof as herbicides. R1 represents alkyl; R2 represents alkyl or cycloalkyl; R3 represents hydrogen, alkyl, alkenyl, alkynyl, aralkyl, alkylsulfonyl, optionally substituted phenylsulfonyl, acyl or acylalkyl; X represents halogen or alkyl; Y represents halogen; n represents 2 or 3, and T represents the above group T1 or T2, wherein R4 represents hydrogen, alkyl, alkoxy or alkylthio.
    Type: Application
    Filed: October 2, 2007
    Publication date: April 15, 2010
    Applicant: Bayer CropScience AG
    Inventors: Shinichi Narabu, Ysushi Yoneta, Akihiko Yanagi, Shinichi Shirakura, Seiji Ukawa, Teruyuki Ichihara, Shin Nakamura, Martin Hills, Heinz Kehne, Jan Dittgen, Dieter Feucht, Christopher Rosinger
  • Publication number: 20100075855
    Abstract: The present invention provides a novel herbicide showing excellent herbicidal effects, which has a wide application range including agricultural fields and non-agricultural fields and various application methods including soil treatment and foliage treatment. A benzoylpyrazole compound represented by the formula (I) or its salt: wherein R1 is alkyl, R2 is a hydrogen atom or alkyl, R3 is alkyl, R4 is alkyl or halogen, R5 is alkyl substituted by one Y1, haloalkoxy, alkoxy substituted by one Y2, or alkoxycarbonyl, R6 is alkylsulfonyl, A is alkylene substituted by at least one alkyl, Y1 is alkoxy or haloalkoxy, and Y2 is alkoxy; a process for its production; a herbicide containing it as an active ingredient; and a method for controlling undesired plants or inhibiting their growth, which comprises applying a herbicidally effective amount thereof to the undesired plants or to a place where they grow.
    Type: Application
    Filed: November 9, 2007
    Publication date: March 25, 2010
    Applicant: Ishihara Sangyo Kaisha, Ltd.
    Inventors: Terumasa Komyoji, Masamitsu Tsukamoto, Hiroshi Kikugawa, Hiroshi Hata
  • Publication number: 20100004129
    Abstract: 4-(3-Alkylsulfinylbenzoyl)pyrazoles of the formula (I) are described as herbicides. In this formula (I), R1 to R4, X and Y are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
    Type: Application
    Filed: May 27, 2009
    Publication date: January 7, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Hartmut Ahrens, Andreas Almsick, Jan Dittgen, Simon Dörner, Dieter Feucht, Isolde Häuser-Hahn, Stefan Lehr, Christopher Hugh Rosinger
  • Publication number: 20090286683
    Abstract: A benzoylpyrazole compound represented by the formula (I) or its salt, useful as herbicides and intermediates thereof.
    Type: Application
    Filed: December 13, 2006
    Publication date: November 19, 2009
    Applicant: ISHIHARA SANGYO KAISHA, LTD.
    Inventors: Hiroshi Shimoharada, Masamitsu Tsukamoto, Masahiko Ikeguchi, Hiroshi Kikugawa, Makiko Sano, Yoshinori Kitahara, Hidemasa Kominami, Tatsuya Okita
  • Publication number: 20090131413
    Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].
    Type: Application
    Filed: July 1, 2005
    Publication date: May 21, 2009
    Applicant: ASUBIO PHARMA CO., LTD.
    Inventors: Hidekazu Inoue, Hidenobu Murafuji, Yasuhiro Hayashi
  • Patent number: 7507833
    Abstract: A compound having a structure and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: March 24, 2009
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Danny T. Dinh
  • Publication number: 20090069184
    Abstract: What is described are 4-(4-trifluoromethyl-3-thiobenzoyl)pyrazoles of the general formula (I) and their use as herbicides. In this formula (I), R1, R2, R3 and R4 are radicals such as hydrogen and organic radicals, such as alkyl. Y is hydrogen or a protective group, such as tosyl.
    Type: Application
    Filed: April 10, 2008
    Publication date: March 12, 2009
    Applicant: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Andreas van Almsick, Monika Schmitt, Jan Dittgen, Martin Hills, Heinz Kehne, Christopher Rosinger, Stefan Lehr, Dieter Feucht
  • Publication number: 20090042730
    Abstract: The invention relates to novel aryl ketones of the formula (I) in which A1, A2, Q, R1, R2, X, Y and Z are as defined in the description, their use as herbicides and processes and intermediates for their preparation.
    Type: Application
    Filed: September 4, 2008
    Publication date: February 12, 2009
    Inventors: Stefan Herrmann, Dorothee Hoischen, Kristian Kather, Klaus-Helmut Muller, Otto Schallner, Hans-Georg Schwarz, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Publication number: 20090029050
    Abstract: A heat-sensitive transfer recording ink sheet, containing a base material sheet and a dye-providing layer formed, wherein at least one kind of yellow dye contained in the dye-providing layer is an arylidenepyrazolone dye represented by formula (1): wherein X represents a substituted or unsubstituted alkoxy group having 1 to 6 carbon atoms; Y represents a halogen atom; R1 represents a substituted or unsubstituted aryl group having 6 to 10 carbon atoms; R2, R5 and R6 each represent a hydrogen atom, an unsubstituted alkyl group having 1 to 4 carbon atoms, an unsubstituted alkoxy group having 1 to 4 carbon atoms, or a halogen atom; and R3 and R4 each represent a substituted or unsubstituted alkyl group having 1 to 5 carbon atoms, or an allyl group.
    Type: Application
    Filed: July 28, 2008
    Publication date: January 29, 2009
    Applicant: FUJIFILM Corporation
    Inventors: Kimihiko SATO, Yoshihiko Fujie, Shinichi Ichikawa, Takashi Hoshimiya, Naotsugu Muro
  • Publication number: 20080305956
    Abstract: What is described are 3-cyclopropyl-4-(3-thiobenzoyl)pyrazoles of the general formula (I) and their use as herbicides In this formula (I), R1, R2, R3, X and Y are radicals such as hydrogen and organic radicals, such as alkyl. R4 is hydrogen or a protective group, such as tosyl.
    Type: Application
    Filed: June 9, 2008
    Publication date: December 11, 2008
    Applicant: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Andreas van Almsick, Stefan Lehr, Monika Schmitt, Jan Dittgen, Dieter Feucht, Martin Hills, Heinz Kehne, Christopher Rosinger