Benzene Ring Is Cyclo In The Tetracyclo Ring System Patents (Class 548/425)
  • Patent number: 5817766
    Abstract: Novel benzpyran derivatives and the use of these derivatives in producing novel anti-cannabinoid antibodies are disclosed. Also disclosed is the use of these antibodies as reagents in improved immunoassays for tetrahydrocannabinol metabolites in biological fluid samples.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: October 6, 1998
    Assignee: Roche Diagnostic Systems, Inc.
    Inventors: Raymond Albert Hui, Steven Mark Rosen, Salvatore Joseph Salmone
  • Patent number: 5629430
    Abstract: Trifluoromethylpyrroloindolecarboxylic acid ester derivatives, and optical isomers and pharmaceutically acceptable salts thereof are provided which are represented by the general formula (1): ##STR1## or the general formula (2): ##STR2## The compounds are antineoplastic agents which are selective to cancer cells, effective also to solid cancer, and less toxic.
    Type: Grant
    Filed: June 14, 1995
    Date of Patent: May 13, 1997
    Assignees: Kyorin Pharmaceutical Co., Ltd., Sagami Chemical Research Center
    Inventors: Shiro Terashima, Yasumichi Fukuda, Yasuo Oomori
  • Patent number: 5457119
    Abstract: New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: October 10, 1995
    Assignee: Eli Lilly and Company
    Inventors: Roseanne Bonjouklian, Richard E. Moore, Gregory M. L. Patterson, Tim A. Smitka
  • Patent number: 5292650
    Abstract: New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: March 8, 1994
    Assignees: Eli Lilly and Company, University of Hawaii
    Inventors: Roseanne Bonjouklian, Richard E. Moore, Gregory M. L. Patterson, Tim A. Smitka
  • Patent number: 5245028
    Abstract: Processes for the preparation of a series of tetracyclic amines useful in the treatment and/or prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: September 14, 1993
    Assignee: Warner-Lambert Company
    Inventor: Thomas C. Malone
  • Patent number: 5212319
    Abstract: New intermediates, and processes therefor, provide an efficient method for deriving 4-amino-1,2,-2a,3,4,5-hexahydrobenz[cd]indoles, which are themselves intermediates to useful CNS agents, from the Kornfeld-Woodward ketone and like compounds. Preferred embodiments provide means for the preparation of substantially pure enantiomers of the desired 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indole.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: May 18, 1993
    Assignee: Eli Lilly and Company
    Inventors: Thomas J. Kress, M. Robert Leanna, Michael J. Martinelli, Barry C. Peterson
  • Patent number: 5109136
    Abstract: A novel series of tetracyclic amines, methods of preparation, compositions containing the amines, and methods for using them in the treatment and/or prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: August 9, 1990
    Date of Patent: April 28, 1992
    Assignee: Warner-Lambert Company
    Inventor: Thomas C. Malone
  • Patent number: 5070093
    Abstract: A novel series of tetracyclic amines, methods of preparation, compositions containing the amines, and methods for using them in the treatment and/or prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: December 3, 1991
    Assignee: Warner-Lambert Company
    Inventor: Thomas C. Malone
  • Patent number: 4870185
    Abstract: New alkaloids called hapalindoles J-Q and T-V, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.
    Type: Grant
    Filed: September 18, 1986
    Date of Patent: September 26, 1989
    Assignees: Eli Lilly and Company, University of Hawaii
    Inventors: Rosanne Bonjouklian, Richard E. Moore, Jon S. Mynderse, Gregory M. L. Patterson, Tim A. Smitka
  • Patent number: 4755610
    Abstract: New alkaloids called hapalindoles, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: July 5, 1988
    Assignee: University of Hawaii
    Inventors: Richard E. Moore, Gregory M. L. Patterson
  • Patent number: 4616035
    Abstract: Combating pests such as insects, arachnids and nematodes with novel N-oxalyl-N-methylcarbamic acid esters of the formula ##STR1## in which R represents alkyl, alkenyl, alkinyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenalkylthio, halogen, nitro, dialkylamino, alkylsulphinyl, alkylsulphonyl, cycloalkyl or a saturated, optionally substituted heterocyclic radical with one or more hetero-atoms from the group comprising O, S and N, or forms a ring which is fused onto the phenyl radical, optionally contains one or more hetero-atoms from the group comprising O, S and N and is optionally substituted.
    Type: Grant
    Filed: October 15, 1984
    Date of Patent: October 7, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Heywang, Engelbert Kuhle, Bernhard Homeyer
  • Patent number: 4602032
    Abstract: A 2-alkyl-9,10-dioxy-4,5,5a,6-tetrahydro-dibenz[cd,f]indole or an acid addition salt thereof is a useful anti-parkinson agent.
    Type: Grant
    Filed: December 19, 1984
    Date of Patent: July 22, 1986
    Assignee: Sandoz Ltd.
    Inventor: Rudolf K. A. Giger
  • Patent number: 4477635
    Abstract: Polymeric and copolymeric aminotriarylmethane dyes having polyester, polyethyleneimine, or polyurethane backbones, and a process for their preparation, are disclosed. The novel dyes are highly colored and resistant to leaching by solvents.
    Type: Grant
    Filed: January 4, 1982
    Date of Patent: October 16, 1984
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Smarajit Mitra
  • Patent number: 4470990
    Abstract: Herein is disclosed compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 each is hydrogen or lower alkyl or R.sup.1 and R.sup.2 together form an alkylene of the formula (CH.sub.2).sub.n wherein n is an integer from 4 to 6, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the compounds and pharmaceutical compositions. The compounds exhibit dopamine-receptor stimulating activity in a mammal and are useful for treating hyperprolactinemia, galactorrhea, amenorrhea, impotence, Parkinsonism, diabetes, acromegaly, hypertension and other central nervous system disorders.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: September 11, 1984
    Assignee: Ayerst, McKenna & Harrison Inc.
    Inventors: Andre A. Asselin, Leslie G. Humber
  • Patent number: 4454325
    Abstract: Novel N-(substituted) derivatives of 2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.0.sup.1,8.0.sup.4,11 ] undecane of the formula: ##STR1## are centrally acting analgesics effective in the relief of pain.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: June 12, 1984
    Assignee: Merck Sharp & Dohme I.A. Corp.
    Inventor: Robert N. Young
  • Patent number: 4376779
    Abstract: Novel N-(substituted) derivatives of 2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.0.sup.1,8.0.sup.4,11 ] undecane of the formula: ##STR1## are centrally acting analgesics effective in the relief of pain.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: March 15, 1983
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Patrice C. Belanger, Robert N. Young