Tetracyclo Ring System Having The Five-membered Hetero Ring As One Of The Cyclos Patents (Class 548/420)
  • Patent number: 11053243
    Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: July 6, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Craig A. Coburn, Steven W. Ludmerer, Kun Liu, Hao Wu, Richard Soil, Bin Zhong, Jian Zhu
  • Patent number: 11000533
    Abstract: A method for treating a non-hemorrhoidal tendon injury in a performance animal in need thereof includes administering to the animal a composition comprising a pro-inflammatory cytokine inhibitor, an antioxidant or catechin, and an anti-inflammatory to thereby treat the non-hemorrhoidal tendon injury in the performance animal.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: May 11, 2021
    Assignee: TRACKSIDE TECHNOLOGIES PTY LTD.
    Inventor: John Daffy
  • Patent number: 9889119
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: February 13, 2018
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, N K Peter Samuel, Joseph Paz, Ying Tan, Dennis E. Hruby
  • Patent number: 9670158
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: June 6, 2017
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, N K Peter Samuel, Joseph Paz, Ying Tan, Dennis E. Hruby
  • Patent number: 9353109
    Abstract: The present invention provides methods for chemically synthesizing analogs and derivatives of naturally-occurring Flindersia alkaloids. Generally, the precursor borrerine is synthesized from tryptamine in the presence of an alkylating agent, an acylating agent and a reducing agent and dimerized in the presence of an acid, for example, trifluoroacetic acid, hydrochloric acid or acetic acid to yield the products. Analog and derivative compounds are produced by derivatizing one or more of the tryptamine, alkylating agent or acylating agent. Also provided are the synthetic alkaloids and derivatives and analogs thereof produced by the synthetic methods.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: May 31, 2016
    Assignee: UNIVERSITY OF HOUSTON SYSTEM
    Inventors: Jeremy A. May, Ravikrishna Vallakati
  • Publication number: 20150060833
    Abstract: The present specification provides a novel compound that is capable of largely improving an expected life span, efficiency, electrochemical stability, and thermal stability of an organic electronic device, and an organic electronic device that includes an organic material layer including the compound.
    Type: Application
    Filed: September 24, 2014
    Publication date: March 5, 2015
    Inventors: Hyok Joon KWON, Kidong KOO, Kongkyeom KIM, Minjun KIM, Seong So KIM, Hyoung Seok KIM, Hyoungcheul KIM, Sang Young JEON, Heungwoo CHOI
  • Publication number: 20150053941
    Abstract: A heterocyclic compound and an organic light-emitting diode including the same, the heterocyclic compound being represented by Formula 1, below:
    Type: Application
    Filed: May 22, 2014
    Publication date: February 26, 2015
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Hye-Jin JUNG, Seok-Hwan HWANG, Young-Kook KIM, Jun-Ha PARK, Eun-Young LEE, Jong-Woo KIM, Jin-O LIM, Sang-Hyun HAN, Kwang-Hyun KIM, Eun-Jae JEONG, Soo-Yon KIM
  • Publication number: 20150056554
    Abstract: Compounds of formula (I), (II), and (III), wherein R1, R2, R?2 and R??2 for example are C1-C20alkyl, provided that at least one of R1, R2, R?2 and R??2 carries a specified substituent; R3, R4, and R5 for example independently of one another are hydrogen or a defined substituent provided that at least one of R3, R4 or R5 is other than hydrogen or C1-C20alkyl; R6, R7, R8, R?7, RV, R?8, R?6, R?7, R??6 and R??7 for example independently of one another have one of the meanings as given for R3, R4, and R5; and R9 for example is C1-C20alkyl; exhibit an unexpectedly good performance in photopolymerization reactions.
    Type: Application
    Filed: November 7, 2014
    Publication date: February 26, 2015
    Applicant: CIBA CORPORATION
    Inventors: Akira Matsumoto, Junichi Tanabe, Hisatoshi Kura, Masaki Ohwa
  • Patent number: 8940909
    Abstract: A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: January 27, 2015
    Assignee: Biosynth AG
    Inventors: Urs Spitz, Lukas Wick, Alexander Bayer, Christophe Weymuth, Günter Schabert
  • Publication number: 20150021574
    Abstract: A material for an organic electroluminescence device and an organic electroluminescence device using the same, the material being represented by the following Formula 1:
    Type: Application
    Filed: July 11, 2014
    Publication date: January 22, 2015
    Inventor: Hiroaki ITOI
  • Publication number: 20140377783
    Abstract: A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.
    Type: Application
    Filed: November 4, 2011
    Publication date: December 25, 2014
    Inventors: Lukas Wick, Urs Spitz, Christophe Weymuth, Günter Schabert, Thomas Mayer, Alexander Bayer
  • Publication number: 20140374722
    Abstract: A compound represented by Formula 1. An organic electric element includes a first electrode, a second electrode, and an organic material layer including the compound of Formula 1. The organic material layer include a light emitting layer, a hole transport layer including a compound represented by Formula 2, and an emission-auxiliary layer including the compound represented by Formula 1. When the organic electric element includes the compound in the organic material layer, luminous efficiency, color purity, and life span can be improved.
    Type: Application
    Filed: January 14, 2013
    Publication date: December 25, 2014
    Inventors: Dongha Kim, Sunhee Lee, Yeonhee Choi, Soungyun Mun, Jungcheol Park, Yongwook Park, Heesun Ji, Junghwan Park, Bumsung Lee, Sunpil Hwang
  • Publication number: 20140361267
    Abstract: Provided is a heterocyclic compound represented by Formula 1 below and an organic light-emitting device including the same. In Formula 1, R1 to R8 are each independently a hydrogen atom, a deuterium atom, a substituted or unsubstituted C1 to C60 alkyl group, a substituted or unsubstituted C3 to C60 cycloalkyl group, a substituted or unsubstituted C2 to C60 heteroaryl group, a substituted or unsubstituted C6 to C60 aryl group, or a substituted or unsubstituted C6 to C60 condensed polycyclic group, with the proviso that R2 is not wherein X is O, S, or Se.
    Type: Application
    Filed: April 11, 2014
    Publication date: December 11, 2014
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Soo-Yon KIM, Seok-Hwan HWANG, Young-Kook KIM, Jun-Ha PARK, Hye-Jin JUNG, Eun-Young LEE, Sang-Hyun HAN, Jin-O LIM, Eun-Jae JEONG, Jong-Hyuk LEE
  • Publication number: 20140361255
    Abstract: A heterocyclic compound is represented by Formula 1 below. An organic light-emitting device includes a first electrode, a second electrode and an organic layer between the first electrode and the second electrode. The organic layer includes the heterocyclic compound. Organic light emitting devices including the heterocyclic compound of Formula 1 exhibit high efficiency, low voltages, high brightness, and long lifespans.
    Type: Application
    Filed: September 26, 2013
    Publication date: December 11, 2014
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jun-Ha Park, Eun-Young Lee, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Jong-Hyuk Lee
  • Publication number: 20140353553
    Abstract: A novel compound represented by general formula (1), a carrier system including a carrier having the novel compound fixed thereon, and a photoelectric conversion device having the carrier system. In formula (1), Z is a C1-C50 conjugated group; R1 is a C6-C20 aromatic hydrocarbon group, a C7-C20 aromatic hydrocarbon group substituted by an aliphatic hydrocarbon group, or a C1-C20 aliphatic hydrocarbon group, each substituted by carboxyl, cyano, amino, amide, or nitro, the aliphatic hydrocarbon group being optionally interrupted by —O—, etc.; R2 is hydrogen or an optionally substituted C1-C20 hydrocarbon group; R30, R31, R32, R33, R40, R41, R42, R43, and R44 are each hydrogen or optionally substituted hydrocarbon group, and adjacent two of them may be connected to form a ring; R5 is hydrogen or cyano; and R11 is represented by formula (11-1) or (11-2), wherein n, ring A, and the like are as defined in the description.
    Type: Application
    Filed: February 27, 2013
    Publication date: December 4, 2014
    Applicant: ADEKA Corporation
    Inventors: Hiroyuki Osada, Yohei Aoyama
  • Publication number: 20140334027
    Abstract: Oxime ester compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 independently of each other are hydrogen, C1-C20alkyl, (A), COR14, NO2, or OR15; provided that at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is (A), and provided that at least one of the remaining R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is COR14 or NO2; R11 is for example C1-C20alkyl, M or (B); X and X1 are for example a direct bond; R12 and R?12 are for example hydrogen or C1-C20alkyl; R13 and R?13 are for example C6-C20aryl or C3-C20heteroaryl; M is (X), (Y) or (Z); X3 is O, S or NR19; R14 and R15 are for example phenyl; R20, R21, R22, R23, R24, or R25 for example are hydrogen, COR14, NO2, or (B); provided that at least two oxime ester groups are present in the molecule; are useful as photoinitiators.
    Type: Application
    Filed: December 3, 2012
    Publication date: November 13, 2014
    Applicant: BASF SE
    Inventors: Yuichi Nishimae, Hisatoshi Kura, Kazuhiko Kunimoto, Ryuhei Yamagami, Keita Tanaka
  • Publication number: 20140291638
    Abstract: The present disclosure provides novel compounds containing dibenzo[fg,op]tetracene and larger all-benzenoid moiety that can be used as hosts for phosphorescent emitters providing low-voltage, high-efficiency and high-stability devices.
    Type: Application
    Filed: February 21, 2014
    Publication date: October 2, 2014
    Applicant: Universal Display Corporation
    Inventors: Raymond KWONG, Kit Yee TSANG, Chuanjun XIA
  • Patent number: 8835651
    Abstract: A photoelectric conversion element includes a working electrode having a dye-supported metal oxide electrode in which a dye is supported on a metal oxide layer, a compound having a structure represented by the following general formula (1): is used as the dye. wherein R1 to R4 are each independently a linear alkyl group having 4 to 20 carbon atoms and may be the same or different; A1 and A2 are each any one selected from the following aromatic ring group A (a pyrrole ring in the formula (1) is represented by an arc a to show a condensation position with the pyrrole ring), may be the same or different, and may have a substituent in an aromatic ring; Anp- is a p-valent anion; p is 1 or 2; and q is a coefficient for keeping a charge of the entire dye neutral.
    Type: Grant
    Filed: December 27, 2010
    Date of Patent: September 16, 2014
    Assignee: Adeka Corporation
    Inventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Yohei Aoyama, Kensaku Akimoto, Toru Yano
  • Publication number: 20140231783
    Abstract: The present invention provides a novel compound that is capable of largely improving a life time, efficiency, electrochemical stability, and thermal stability of an organic electronic device, and an organic electronic device that comprises an organic material layer comprising the compound.
    Type: Application
    Filed: April 28, 2014
    Publication date: August 21, 2014
    Applicant: LG CHEM, Ltd.
    Inventors: Jae-Soon BAE, Ji-Eun KIM, Hye-Young JANG, Jeung-Gon KIM, Jun-Gi JANG, Sung-Kil HONG, Tae-Yoon PARK, Dae-Woong LEE
  • Patent number: 8808880
    Abstract: A condensed-cyclic compound represented by Formula 1 below, an organic light-emitting device including the same, and a flat panel display apparatus including the organic light-emitting device: wherein, X, Y, A1, A2, L1, L2, L3, Ar1, R1, R2, R3, R4, R5, R6, a, b, c, d, e, f, and g are described in the detailed description of the invention. The organic light-emitting device including an organic layer including the compound above has low driving voltage, high emission efficiency, and long lifetime.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: August 19, 2014
    Assignee: Samsung Display Co., Ltd.
    Inventors: Hee-Yeon Kim, Seung-Gak Yang, Jeoung-In Yi, Jae-Yong Lee
  • Patent number: 8765738
    Abstract: Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: July 1, 2014
    Assignee: Incuron, LLC
    Inventors: John Tucker, Sergey Sviridov, Leonid Brodsky, Catherine Burkhart, Andrei Purmal, Katerina Gurova, Andrei Gudkov
  • Publication number: 20140167026
    Abstract: A nitrogen-containing aromatic heterocyclic derivative in which a nitrogen atom of an indenocarbazole skeleton optionally having a hetero atom or an indenoindole skeleton optionally having a hetero atom is bonded to a dibenzofuran or a dibenzothiophene directly or indirectly. The derivative realizes an organic EL device with a high emission efficiency and a long lifetime.
    Type: Application
    Filed: July 11, 2012
    Publication date: June 19, 2014
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Tomoki Kato, Nobuhiro Yabunouchi, Takahiro Fujiyama
  • Patent number: 8716493
    Abstract: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: May 6, 2014
    Assignee: Cephalon, Inc.
    Inventors: Sankar Chatterjee, Reddeppa reddy Dandu, James L. Diebold, Derek D. Dunn, Robert L. Hudkins, Gregory J. Wells, Allison L. Zulli
  • Publication number: 20140114068
    Abstract: Disclosed are novel indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
    Type: Application
    Filed: June 18, 2012
    Publication date: April 24, 2014
    Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Young Sik Jung, Chong Kgo Lee, Hae Soo Kim, Hee Chun Jeong, Pil Ho Kim, Soo Bong Han, Jin Soo Shin, Johan Neyts, Hendrik Jan Thibaut
  • Publication number: 20140027747
    Abstract: The present invention relates to a compound, which is represented by one chemical formula among the chemical formulas (1) to (3), an organic electronic element comprising the compound, and an electronic device comprising the organic electronic element. The compound is characterized by comprising at least one phenyl group having at least one substitution with deuterium or tritium.
    Type: Application
    Filed: March 29, 2012
    Publication date: January 30, 2014
    Applicant: DUKSAN HIGH METAL CO., LTD.
    Inventors: Soungyun Mun, Bumsung Lee, Jungcheol Park, Kiwon Kim, Yongwook Park, Jeongkeun Park, Heesun Ji, Junghwan Park
  • Publication number: 20130270524
    Abstract: A compound represented by Formula 1 below may be used in an organic light emitting diode.
    Type: Application
    Filed: October 2, 2012
    Publication date: October 17, 2013
    Applicant: SAMSUNG DISPLAY CO. LTD.
    Inventors: Jun-Ha Park, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Eun-Young Lee, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Se-Jin Cho, Jong-Hyuk Lee
  • Publication number: 20130264547
    Abstract: An organic electroluminescent element including a substrate, a pair of electrodes including an anode and a cathode, disposed on the substrate, and at least one layer of organic layers including a light emitting layer, disposed between the electrodes, in which at least one of the organic layers contains a compound represented by the following general formula: (R1 to R18 each independently represent a hydrogen atom or a substituent, and at least one of R1 to R8 and R10 to R17 represents -L-NR19R20 (R19 and R20 each independently represent any of an alkyl group, an aryl group, a heteroaryl group. R19 and R20 may be combined to each other to form a ring. L represents a single bond or a divalent linking group). X1 to X18 each independently represent a carbon atom or a nitrogen atom, and when X1 to X18 represent nitrogen atoms, R1 to R18 for bonding do not present.
    Type: Application
    Filed: February 4, 2013
    Publication date: October 10, 2013
    Applicant: UDC Ireland Limited
    Inventors: Tetsu Kitamura, Tenka Ouyo, Yuki Hirai, Koji Takaku, Wataru Sotoyama, Masaru Kinoshita, Kuniyuki Kaminaga, Yosuke Yamamoto
  • Publication number: 20130190511
    Abstract: The present invention provides methods for chemically synthesizing naturally-occurring alkaloids, for example, Flindersia alkaloids, and their analogs and derivatives. Generally, the precursor borrerine is synthesized from tryptamine in the presence of an alkylating agent, an acylating agent and a reducing agent and dimerized in the presence of an acid, for example, tetrafluoroacetic acid, hydrochloric acid or acetic acid to yield the products. Analog and derivative compounds are produced by derivatizing one or more of the tryptamine, alkylating agent or acylating agent. Also provided are the synthetic alkaloids and derivatives and analogs thereof produced by the synthetic methods.
    Type: Application
    Filed: January 18, 2013
    Publication date: July 25, 2013
    Inventors: Jeremy A. May, Ravikrishna Vallakati
  • Publication number: 20130188270
    Abstract: Compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 for example independently of each other are hydro-gen, C1-C20alkyl, (II), COR16 or NO2, provided that at least one pair of R1 and R2, R2 and R3, R3 and R4, R5 and R6, R6 and R7, or R7 and R8 is (III); R9, R10, R11 and R12 for example independently of each other are hydrogen, C1-C20alkyl which optionally substituted; or R9, R10, R11, and R12 independently of each other are unsubstituted or substituted phenyl; X is CO or a direct bond; R13 is for example C1-C20alkyl which optionally is substituted, C2-C12alkenyl, C4-C8cycloalkenyl, C2-C12alkinyl, C3-C10-cycloalkyl, phenyl or naphthyl both of which are optionally substituted; R14 is for example hydrogen, C3-C8cycloalkyl, C2-C5alkenyl, C1-C20alkoxy, C1-C20alkyl, phenyl or naphthyl; R15 is for example C6-C20aryl or C5-C20heteroaryl; R16 is for example C6-C20aryl which is unsubstituted or substituted by one or more C1-C20alkoxy or C1-C20alkyl; are in particular suitable as photoinitiators for c
    Type: Application
    Filed: October 4, 2011
    Publication date: July 25, 2013
    Applicant: BASF SE
    Inventors: Yuichi Nishimae, Hisatoshi Kura, Kazuhiko Kunimoto, Ryuhei Yamagami, Keita Tanaka
  • Publication number: 20130026426
    Abstract: A carbazole derivative represented by the following General Formula (1) where at least one aromatic ring has one to three substituents each represented by the following General Formula (2): in General Formula (1), Ar1 and Ar2 each independently represent a substituted or unsubstituted aryl group which may form a ring with a benzene ring, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted arylsilyl group, or a hydrogen atom, and Ar3 represents a substituted or unsubstituted aryl group, —X—Y—Z??(2) in General Formula (2), X represents a methylene group, a carbonyloxy group, an oxycarbonyl group, a carbonyl group, an oxygen atom or a sulfur atom, Y represents a substituted or unsubstituted alkylene group, and Z represents a carboxyl group, a hydroxyl group or a thiol group.
    Type: Application
    Filed: March 29, 2012
    Publication date: January 31, 2013
    Inventors: Shigeyuki HARADA, Masaomi Sasaki
  • Patent number: 8343637
    Abstract: The present invention relates to compounds of the formula (1) and to the use thereof in organic electroluminescent devices, in particular as matrix material in phosphorescent devices.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: January 1, 2013
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Jonas Kroeber, Arne Buessing, Horst Vestweber
  • Patent number: 8338000
    Abstract: Embodiments of the present invention are directed to a heterocyclic compound and an organic light-emitting device including the heterocyclic compound. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltage, high luminance and long lifespan.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: December 25, 2012
    Assignee: Samsung Display Co., Ltd.
    Inventors: Yoon-Hyun Kwak, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jong-Hyuk Lee, Jin-O Lim, Hyung-Jun Song
  • Publication number: 20120286247
    Abstract: A condensed-cyclic compound represented by Formula 1 below, an organic light-emitting device including the same, and a flat panel display apparatus including the organic light-emitting device: wherein, X, Y, A1, A2, L1, L2, L3, Ar1, R1, R2, R3, R4, R5, R6, a, b, c, d, e, f, and g are described in the detailed description of the invention. The organic light-emitting device including an organic layer including the compound above has low driving voltage, high emission efficiency, and long lifetime.
    Type: Application
    Filed: September 23, 2011
    Publication date: November 15, 2012
    Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.
    Inventors: Hee-Yeon Kim, Seung-Gak Yang, Jeoung-In Yi, Jae-Yong Lee
  • Patent number: 8222425
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: July 17, 2012
    Assignee: Novartis AG
    Inventors: Shawn D. Britt, Lech Andrzej Ciszewski, Jiping Fu, Subramanian Karur, Yugang Liu, Peichao Lu, David Thomas Parker, Mahavir Prashad, Prakash Raman, Pascal Rigollier, Mohindra Seepersaud, Aregahegn Yifru, Rui Zheng
  • Publication number: 20120083488
    Abstract: A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
    Type: Application
    Filed: June 9, 2010
    Publication date: April 5, 2012
    Inventors: Kazutomo Kinoshita, Kohsuke Asoh, Noriyuki Furuichi, Toshiya Ito, Hatsuo Kawada, Nobuya Ishii, Hiroshi Sakamoto, WooSang Hong, MinJeong Park, Yoshiyuki Ono, Yashuharu Kato, Kenji Morikami, Takashi Emura, Nobuhiro Oikawa
  • Publication number: 20120070409
    Abstract: The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
    Type: Application
    Filed: February 3, 2011
    Publication date: March 22, 2012
    Applicant: Japan Tobacco Inc.
    Inventors: Takahiro Oka, Kazutaka Ikegashira, Shintaro Hirashima, Hiroshi Yamanaka, Satoru Noji, Yasushi Niwa, Yoko Matsumoto, Toshihiro Sato, Izuru Ando, Yukihiro Nomura
  • Patent number: 8133913
    Abstract: Synthesis of novel substituted indeno[1,2-b]indole derivatives of the type of 5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-diones and 5H-indeno[1,2-b]indole-6,9,10-triones, which show pronounced inhibition of the human protein kinase CK2, and the use thereof as active ingredients in medicaments and/or drug products in particular for the treatment of neoplastic diseases.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: March 13, 2012
    Assignee: Heinrich-Heine Universitat Dusseldof
    Inventors: Hans-Jorg Hemmerling, Claudia Gotz, Joachim Jose
  • Publication number: 20120058503
    Abstract: A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.
    Type: Application
    Filed: May 6, 2010
    Publication date: March 8, 2012
    Applicant: Biosynth AG
    Inventors: Urs Spitz, Lukas Wick, Alexander Bayer, Christophe Weymuth, Günter Schabert
  • Publication number: 20110305661
    Abstract: Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases.
    Type: Application
    Filed: October 5, 2009
    Publication date: December 15, 2011
    Inventors: John Tucker, Sergey Sviridov, Leonid Brodsky, Catherine Burkhart, Andrei Purmal, Katerina Gurova, Andrei Gudkov
  • Publication number: 20110269810
    Abstract: Compositions and methods for treating, preventing, or ameliorating one or more symptoms, disorders, or conditions associated with particular c-Jun N-terminal kinase(s) (JNKs) activity are provided. Compositions contain small molecules such as pyrazoloanthrones.
    Type: Application
    Filed: April 4, 2011
    Publication date: November 3, 2011
    Applicants: Regents of the University of Minnesota, Mayo Foundation for Medical Education and Research
    Inventors: Yuan-Ping Pang, Anuradha Vummenthala, Jewn Giew Park, Shao-Hua Wang, Zigang Dong, Ann M. Bode, Yong Yeon Cho
  • Publication number: 20110210318
    Abstract: The present invention provides a novel compound that is capable of largely improving a life time, efficiency, electrochemical stability, and thermal stability of an organic electronic device, and an organic electronic device that comprises an organic material layer comprising the compound.
    Type: Application
    Filed: August 21, 2009
    Publication date: September 1, 2011
    Applicant: LG CHEM, LTD.
    Inventors: Jae-Soon Bae, Ji-Eun Kim, Hye-Young Jang, Jeung-Gon Kim, Jun-Gi Jang, Sung-Kil Hong, Tae-Yoon Park, Dae-Woong Lee
  • Patent number: 7977331
    Abstract: The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: July 12, 2011
    Assignee: Japan Tobacco Inc.
    Inventors: Takahiro Oka, Kazutaka Ikegashira, Shintaro Hirashima, Hiroshi Yamanaka, Satoru Noji, Yasushi Niwa, Yoko Matsumoto, Toshihiro Sato, Izuru Ando, Yukihiro Nomura
  • Patent number: 7964739
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: June 21, 2011
    Assignee: N.V. Organon
    Inventor: Gerardus Johannes Kemperman
  • Publication number: 20110046378
    Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease
    Type: Application
    Filed: February 17, 2009
    Publication date: February 24, 2011
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Qianwa Liang, Brian A. Duclos, Wei Zhang, Peter J.H. Scott, Kai Chen, Zhiyong Gao, Tieming Zhao, Vani P. Mocharla, Dhanalakshmi Kasi, Gang Chen, Eric Wang, Anjana Sinha, Chunfang Xia, Henry Clifton Padgett, Farhad Karimi
  • Publication number: 20110037060
    Abstract: Embodiments of the present invention are directed to a heterocyclic compound and an organic light-emitting device including the heterocyclic compound. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltage, high luminance and long lifespan.
    Type: Application
    Filed: August 10, 2010
    Publication date: February 17, 2011
    Inventors: Young-Kook Kim, Seok-Hwan Hwang, Yoon-Hyun Kwak, Hye-Jin Jung, Jong-Hyuk Lee, Jin-O Lim, Hee-Joo Ko
  • Publication number: 20110031484
    Abstract: A condensed-cyclic compound represented by Formula 1 and an organic light emitting diode including the same:
    Type: Application
    Filed: August 9, 2010
    Publication date: February 10, 2011
    Applicant: Samsung Mobile Display Co., Ltd.
    Inventors: Kwan-Hee Lee, Mi-Kyung Kim, Seung-Gak Yang
  • Publication number: 20110031483
    Abstract: Embodiments of the present invention are directed to a heterocyclic compound and an organic light-emitting device including the heterocyclic compound. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltage, high luminance and long lifespan.
    Type: Application
    Filed: August 6, 2010
    Publication date: February 10, 2011
    Inventors: Yoon-Hyun Kwak, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jong-Hyuk Lee, Jin-O Lim, Hyung-Jun Song
  • Patent number: 7781476
    Abstract: Tetracyclic 3-substituted indoles having serotonin receptor affinity and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: August 24, 2010
    Assignee: Suven Life Sciences Limited
    Inventors: Venkata Satya Nirogi Ramakrishna, Vikas Shreekrishna Shirsath, Rama Sastri Kambhampati, Venkata Satya Veerabhadra Vadlamudi Rao, Venkateswarlu Jasti
  • Publication number: 20100204239
    Abstract: The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 12, 2010
    Inventors: Zhihua Sui, Xuqing Zhang, Xiaojie Li
  • Patent number: 7750167
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: July 6, 2010
    Assignee: N.V. Organon
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden