The Five-membered Hetero Ring Shares Ring Members With One Other Cyclo Only Patents (Class 548/426)
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Organic compounds and electronic device comprising an organic layer comprising the organic compounds
Patent number: 10005729Abstract: Organic compounds suitable for organic layers of electronic devices that show improved luminescent properties.Type: GrantFiled: December 25, 2015Date of Patent: June 26, 2018Assignees: ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD, DOW GLOBAL TECHNOLOGIES LLCInventors: Zhengming Tang, Chong Xing, Shaoguang Feng, Hong-Yeop Na, Minrong Zhu, Robert J. Wright, David D. Devore -
Patent number: 9424999Abstract: A photoelectric conversion device that includes a work electrode, an opposed electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided. The dye contains a cyanine compound that has a methine chain, an indolenine skeleton bonded with both ends of the methine chain, and anchor groups introduced to a nitrogen atom included in the indolenine skeleton. Electron injection efficiency to the metal oxide semiconductor layer is improved, and the dye is hardly exfoliated from the metal oxide semiconductor layer.Type: GrantFiled: September 18, 2014Date of Patent: August 23, 2016Assignee: ADEKA CORPORATIONInventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Mitsuhiro Okada, Toru Yano, Yohei Aoyama, Yusuke Kubota
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Publication number: 20150079625Abstract: The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.Type: ApplicationFiled: March 5, 2012Publication date: March 19, 2015Applicants: DALIAN CHROMAS BIOSCIENCE CO., LTD, DALIAN UNIVERSITY OF TECHNOLOGYInventors: Xiaojun Peng, Hua Zhang, Jiangli Fan, Jingyun Wang
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Publication number: 20140374722Abstract: A compound represented by Formula 1. An organic electric element includes a first electrode, a second electrode, and an organic material layer including the compound of Formula 1. The organic material layer include a light emitting layer, a hole transport layer including a compound represented by Formula 2, and an emission-auxiliary layer including the compound represented by Formula 1. When the organic electric element includes the compound in the organic material layer, luminous efficiency, color purity, and life span can be improved.Type: ApplicationFiled: January 14, 2013Publication date: December 25, 2014Inventors: Dongha Kim, Sunhee Lee, Yeonhee Choi, Soungyun Mun, Jungcheol Park, Yongwook Park, Heesun Ji, Junghwan Park, Bumsung Lee, Sunpil Hwang
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Patent number: 8912344Abstract: A photoelectric conversion device capable of improving conversion efficiency is provided. The photoelectric conversion device includes a work electrode, a counter electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided. The dye contains a cyanine compound. The cyanine compound has heterocyclic skeletons containing indolenine skeletons bonded with both ends of a methine chain, an anchor group introduced to a nitrogen atom contained in the indolenine skeletons, and a phenanthrene skeleton contained in one of the heterocyclic skeletons. In the case where light enters the dye, electron injection efficiency to the metal oxide semiconductor layer is improved.Type: GrantFiled: December 25, 2009Date of Patent: December 16, 2014Assignee: Adeka CorporationInventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Toru Yano, Yukiko Mae, Yohei Aoyama
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Publication number: 20140361259Abstract: An arylamine-based compound is represented by Formula 1 below. The arylamine-based compound is included in an organic light emitting diode.Type: ApplicationFiled: October 23, 2013Publication date: December 11, 2014Applicant: SAMSUNG DISPLAY CO., LTD.Inventors: Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jun-Ha Park, Eun-Young Lee, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Jong-Hyuk Lee
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Publication number: 20140200353Abstract: Disclosed are compounds of formula (I) and salts, hydrates, or solvates thereof, where R1 and R2 are defined herein, compositions containing these compounds, and methods of using these compounds in a variety of applications, such as a surfactant or performance additive.Type: ApplicationFiled: August 16, 2012Publication date: July 17, 2014Applicant: DOW GLOBAL TECHNOLOGIES ,LLCInventors: Brad C. Bailey, Sze-Sze Ng, Cynthia Pierre, Cynthia L. Rand
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Patent number: 8697690Abstract: The present invention is directed to isoindolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.Type: GrantFiled: June 27, 2011Date of Patent: April 15, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Douglas C. Beshore, Scott D. Kuduk, Youheng Shu, Zhi-Qiang Yang
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Patent number: 8614333Abstract: The present invention relates to acenaphtho heterocyclic compounds and their uses in manufacturing the BH3 mimetics as Bcl-2-like protein inhibitors. Structures are shown in the following: Statistical analysis of their bio-activities showed these compounds exhibit better BH3 mimicking property than the reported compounds. These compounds can simulate BH3-only protein, competitively bind and antagonizing Bcl-2 and Mcl-1 proteins in vitro and in cells, and then induce apoptosis. Therefore, they all can be used in the manufactures of anticancer compounds.Type: GrantFiled: July 27, 2011Date of Patent: December 24, 2013Assignee: Dalian University of TechnologyInventors: Zhichao Zhang, Guiye Wu
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Patent number: 8466189Abstract: The present invention relates to a compound of formula (I) where T, Q1, R1 to R6 and R30 are each as defined in claim 1, to their preparation and to their use.Type: GrantFiled: August 20, 2009Date of Patent: June 18, 2013Assignee: Clariant (Produkte) Deutschland GmbHInventors: Gunter Görlitz, Carsten Harfmann, Roxana Barbieru
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Publication number: 20130109686Abstract: The present invention is directed to isoindolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.Type: ApplicationFiled: June 27, 2011Publication date: May 2, 2013Inventors: Douglas C. Beshore, Scott D. Kuduk, Youheng Shu, Zhi-Qiang Yang
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Patent number: 8415347Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: GrantFiled: August 5, 2010Date of Patent: April 9, 2013Assignee: Janssen Pharmaceutica, NVInventors: José Maria Cid-Núñez, Antonius Adrianus Hendrikus Petrus Megens, Andrés Avelino Trabanco-Suárez, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernández-Gadea
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Publication number: 20130037782Abstract: A heterocyclic compound represented by Formula 1 below and an organic light-emitting diode (OLED) including the same: wherein R1 through R12, Ar1, Ar2, A, B, a, and b are the same as defined above. An OLED including an organic layer including the heterocyclic compound has low driving voltage, high luminous efficiency, and a long lifetime.Type: ApplicationFiled: January 9, 2012Publication date: February 14, 2013Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Sang-Hyun Han, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jin-O Lim, Soo-Yon Kim, Il-Soo Oh, Jong-Hyuk Lee
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Patent number: 8362276Abstract: The present invention provides a novel ?-sulfonimide compound having at least one imide group and at least one sulfonyl group and a method for preparing the same.Type: GrantFiled: April 5, 2006Date of Patent: January 29, 2013Assignee: INKTEC Co., Ltd.Inventors: Kwang-Choon Chung, Hyun-Nam Cho, Myoung-Seon Gong, Yun-Ho Jung
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Patent number: 8242162Abstract: Aromatic molecules that can be used as sensors are described. The aromatic sensors include a polycyclic aromatic hydrocarbon core with a five-membered imide rings fused to the core and at least two pendant aryl groups. The aromatic sensor molecules can detect target analytes or molecular strain as a result of changes in their fluorescence, in many cases with on-off behavior. Aromatic molecules that fluoresce at various frequencies can be prepared by altering the structure of the aromatic core or the substituents attached to it. The aromatic molecules can be used as sensors for various applications such as, for example, the detection of dangerous chemicals, biomedical diagnosis, and the detection of damage or strain in composite materials. Methods of preparing aromatic sensor molecules are also described.Type: GrantFiled: December 14, 2007Date of Patent: August 14, 2012Assignees: Ohio Aerospace Institute, The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Michael A. Meador, Daniel S. Tyson, Ulvi F. Ilan
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Patent number: 8222425Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.Type: GrantFiled: July 19, 2011Date of Patent: July 17, 2012Assignee: Novartis AGInventors: Shawn D. Britt, Lech Andrzej Ciszewski, Jiping Fu, Subramanian Karur, Yugang Liu, Peichao Lu, David Thomas Parker, Mahavir Prashad, Prakash Raman, Pascal Rigollier, Mohindra Seepersaud, Aregahegn Yifru, Rui Zheng
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Publication number: 20110272681Abstract: A light-emitting element has high luminous efficiency and excellent durability. The light-emitting element includes at least a light-emitting layer between a positive electrode and a negative electrode, and emits light by electrical energy. The light-emitting element is characterized by containing a naphthacene compound that has a specific structure and organic fluorescent substance that has a fluorescence peak wavelength of not less than 500 nm but not more than 690 nm.Type: ApplicationFiled: January 19, 2010Publication date: November 10, 2011Applicant: TORAY INDUSTRIES, INC.Inventors: Kazunori Sugimoto, Tsuyoshi Tominaga
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Publication number: 20110253218Abstract: A photoelectric conversion device capable of improving conversion efficiency is provided. The photoelectric conversion device includes a work electrode, a counter electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided. The dye contains a cyanine compound. The cyanine compound has heterocyclic skeletons containing indolenine skeletons bonded with both ends of a methine chain, an anchor group introduced to a nitrogen atom contained in the indolenine skeletons, and a phenanthrene skeleton contained in one of the heterocyclic skeletons. In the case where light enters the dye, electron injection efficiency to the metal oxide semiconductor layer is improved.Type: ApplicationFiled: December 25, 2009Publication date: October 20, 2011Applicants: ADEKA CORPORATION, TDK CORPORATIONInventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Toru Yano, Yukiko Mae, Yohei Aoyama
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Patent number: 8022228Abstract: The invention relates to an orthorhombic crystal form of compound trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole(Z)-2-butenedioate, to methods for the preparation of this crystal form and to pharmaceutical compositions comprising an orthorhombic crystal form.Type: GrantFiled: November 13, 2007Date of Patent: September 20, 2011Assignee: N.V. OrganonInventor: Gerhardus Johannes Heeres
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Publication number: 20110224334Abstract: A near-infrared-ray absorbing material which contains a cyanine compound represented by general formula (I), shows a narrow peak of light absorption in the range of wavelengths of 800-1,000 nm, and has excellent light resistance. In formula (I), R1 to R4, Y1, and Y2 each represents a hydrogen atom, a group of formula (II) or (II?), etc., and Anq? represents a q-valent anion, provided that at least R1 is a group of formula (II) or (II') or Anq? is an ion of formula (III); R11 to R13 each represents a hydrogen atom, hydroxy, etc.; and Z1 and Z2 each represents a C1-10 alkyl, etc. In formula (II?), the bond between G? and T? is a double bond or a conjugated double bond; G? represents a carbon atom; T? represents a carbon atom or a nitrogen atom; the ring including G? and T? represents a 6-membered ring, etc.; w? is 0-4; and R01? represents a hydrogen atom, hydroxy, etc. In formula (III), R5 and R6 each represents a C1-8 haloalkyl.Type: ApplicationFiled: November 18, 2009Publication date: September 15, 2011Applicant: ADEKA CORPORATIONInventors: Yosuke Maeda, Ryoya Otsuki, Koichi Shigeno
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Publication number: 20110218276Abstract: The present invention relates to a compound of formula (I) where T, Q1, R1 to R6 and R30 are each as defined in claim 1, to their preparation and to their use.Type: ApplicationFiled: August 20, 2009Publication date: September 8, 2011Applicant: DyStar Colours Deutschland GmbHInventors: Gunter Görlitz, Carsten Harfmann, Roxana Barbieru
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Publication number: 20110049486Abstract: Embodiments of the present invention are directed to a heterocyclic compound and an organic light-emitting device including the heterocyclic compound. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltages, high brightness and long lifespans.Type: ApplicationFiled: August 12, 2010Publication date: March 3, 2011Inventors: Yoon-Hyun Kwak, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jong-Hyuk Lee, Jin-O Lim
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Publication number: 20100331325Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: ApplicationFiled: August 5, 2010Publication date: December 30, 2010Inventors: José Maria CID-NÚÑEZ, Antonius Adrianus Hendrikus Petrus MEGENS, Andrés Avelino TRABANCO-SUÁREZ, Mohamed KOUKNI, Georges Joseph Cornelius HOORNAERT, Frans Josef Cornelius COMPERNOLLE, Tomasz KOZLECKI, Hua MAO, Sushil Chandra JHA, Francisco Javier FERNÁNDEZ-GADEA
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Patent number: 7799785Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: GrantFiled: December 6, 2005Date of Patent: September 21, 2010Assignee: Janssen Pharmaceutica NVInventors: José Maria Cid-Núñez, Antonius Andrianus Hendrikus Petrus Megens, Andrés Avelino Trabanco-Suárez, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernández-Gadea
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Publication number: 20090023721Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: ApplicationFiled: May 24, 2006Publication date: January 22, 2009Inventors: Antonius Adrianus Hendrikus Petrus Megens, Andres Avelino Trabanco-Suarez, Jose Maria Cid-Nunez, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernandez-Gadea, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki
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Publication number: 20080318331Abstract: The use of compounds of the general formula (I) as markers for liquids, methods for detecting markers in liquids, methods for identifying liquids and selected compounds of the general formula (I).Type: ApplicationFiled: December 12, 2007Publication date: December 25, 2008Applicant: BASF SEInventors: Rüdiger Sens, Thomas Gessner, Sophia Ebert, Christos Vamvakaris, Wolfgang Ahlers
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Publication number: 20080287450Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: ApplicationFiled: December 6, 2005Publication date: November 20, 2008Inventors: Jose Maria Cid-Nunez, Antonius Adrianus Hendrikus Petrus Megens, Andres Avelino Trabanco-Suarez, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernandez-Gadea
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Publication number: 20080262243Abstract: The present invention provides a novel ?-sulfonimide compound having at least one imide group and at least one sulfonyl group and a method for preparing the same.Type: ApplicationFiled: April 5, 2006Publication date: October 23, 2008Applicant: INKTEC CO., LTD.Inventors: Kwang-Choon Chung, Hyun-Nam Cho, Myoung-Seon Gong, Yun-Ho Jung
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Patent number: 7345034Abstract: Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.Type: GrantFiled: April 1, 2005Date of Patent: March 18, 2008Assignee: Abbott LaboratoriesInventors: Chen Zhao, Minghua Sun, Marlon D. Cowart, Youssef L. Bennani
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Patent number: 6828159Abstract: The invention relates to the use of carbopyronine compounds of general formula (I) as marker groups in methods for detecting analytes. The invention also relates to novel carbopyronine compounds and to a method for producing same.Type: GrantFiled: October 26, 2001Date of Patent: December 7, 2004Inventors: Karl-Heinz Drexhage, Jutta Arden-Jacob, Jörg Frantzeskos, Alexander Zilles
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Patent number: 6291679Abstract: The present invention relates to a novel process for the preparation of benzoperhydroisindole compounds.Type: GrantFiled: July 26, 1999Date of Patent: September 18, 2001Assignee: Rhone-Poulenc Rorer S.A.Inventors: Patrick Mailliet, Christophe Salagnad
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Patent number: 6130101Abstract: The present invention describes xanthene dyes, including rhodamines, rhodols and fluoresceins that are substituted one or more times by a sulfonic acid or a salt of a sulfonic acid. The dyes of the invention, including chemically reactive dyes and dye-conjugates are useful as fluorescent probes, particularly in biological samples.Type: GrantFiled: September 23, 1997Date of Patent: October 10, 2000Assignee: Molecular Probes, Inc.Inventors: Fei Mao, Wai-Yee Leung, Richard P. Haugland
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Patent number: 5977379Abstract: The invention relates to the preparation of halogenated imides derived from hydrazine, a halogen and a dicarboxylic acid anhydride and capable of being employed as fireproofing agents for plastics.A dicarboxylic acid anhydride is halogenated with bromine, chlorine or a mixture thereof and then the product thus obtained is subsequently reacted with hydrazine. No prior purification or isolation of the intermediate halogenated anhydride is required.Type: GrantFiled: March 19, 1992Date of Patent: November 2, 1999Assignee: AtochemInventors: Evelyne Bonnet, Bernard Gurtner
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Patent number: 5936097Abstract: Novel products of formula (I): ##STR1## preparation thereof and pharmaceutical compositions containing said products are disclosed. In formula (I), R is a group of formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z, where X.sub.1 is a simple bond or O or S, n is 0 or 1 and n is 0, 1 or 2, the CH.sub.2 groups being optionally substituted by carboxy, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, amino, alkylamino or dialkylamino, and Z is carboxy, COOR.sub.4, where R.sub.4 is alkyl, or CON(R.sub.5)(R.sub.6), where R.sub.5 hydrogen or alkyl and R.sub.6 is hydrogen or optionally substituted alkyl, or else R.sub.5 is hydrogen or alkyl and R.sub.6 is hydroxy, optionally substituted alkoxy or amino, or PO(OR.sub.7).sub.2, where R.sub.7 is hydrogen or alkyl; or a group --NH--CO--T where T is hydrogen or optionally substituted alkyl; or else a group (a); R.sub.1 and R.sub.2 are hydrogen or halogen or optionally substituted alkyloxy or alkyl, or else R.sub.1 and R.sub.Type: GrantFiled: July 23, 1998Date of Patent: August 10, 1999Assignee: Rhone-Poulenc Rorer, S.A.Inventors: Alain Commer.cedilla.on, Alain Le Brun, Patrick Mailliet, Jean-Fran.cedilla.ois Peyronel, Fabienne Sounigo-Thompson, Alain Truchon, Martine Zucco
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Patent number: 5869691Abstract: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.Type: GrantFiled: April 8, 1997Date of Patent: February 9, 1999Assignee: Eli Lilly and CompanyInventors: James E. Audia, Stephen Richard Baker, Jesus Ezquerra Carrera, Carlos Lamas Peteira, Concepcion Pedregal Tercero
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Patent number: 5854273Abstract: A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino,Z represent a linear or branched C.sub.4 to C.sub.12 alkylene chain in which one or more --CH.sub.2 -- are optionally replaced by any one of the following atoms or groups: --NR--, --O--, --S--, --SO--, --SO.sub.2 --, or --CONH--,A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, ##STR2## represents any one of the groups as defined in the description, its optical isomers and its addition salts with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as anticancer agents.Type: GrantFiled: July 23, 1997Date of Patent: December 29, 1998Assignee: ADIR et CompagnieInventors: Gilbert Lavielle, Patrick Hautefaye, Ghanem Atassi, Alain Pierre, Laurence Kraus-Berthier, Stephane Leonce
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Patent number: 5852204Abstract: The present invention relates to heterocyclic compounds which have been found to have anti-tumor activity. More specifically, the invention concerns pyrrolo?3,2-b!carbazoles and 1H-?1! benzothieno ?2,3-f! indoles, methods for their preparation, pharmaceutical formulations containing them and their use as anti-tumor agents. The compounds have low toxicity against normal cell lines while exhibiting anti-tumor cell activity.Type: GrantFiled: August 16, 1996Date of Patent: December 22, 1998Assignee: University College Cardiff Consultants LimitedInventors: David Drysdale Miller, Sadie Vile, Patrick Vivian Richard Shannon, Laddawan Chunchatprasert, Alan Thomas Hudson
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Patent number: 5708186Abstract: This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the .alpha.-halo acid with an aryloxy group.Type: GrantFiled: December 6, 1996Date of Patent: January 13, 1998Inventors: Paul N. Devine, David M. Tschaen, Richard M. Heid, Jr.
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Patent number: 5612356Abstract: A heterocycle-containing carbonic acid derivative represented by the following general formula (I): ##STR1## or a physiologically acceptable salt thereof which exhibits an excellent preventive and therapeutic effect against various diseases, and an intermediate which is useful for the production of the heterocycle-containing carbonic acid derivative.Type: GrantFiled: April 25, 1995Date of Patent: March 18, 1997Assignee: Eisai Co., Ltd.Inventors: Hiroyuki Yoshimura, Mitsuo Nagai, Shigeki Hibi, Koichi Kikuchi, Ieharu Hishinuma, Junichi Nagakawa, Makoto Asada, Norimasa Miyamoto, Takayuki Hida, Aichi Ogasawara, Isao Yamatsu
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Patent number: 5389141Abstract: Pigment compositions comprisinga) at least one pyrrolo[3,4-c]pyrrole pigment of the formula ##STR1## in which A and B, independently of one another, are isocyclic or heterocyclic aromatic radicals, and D is an oxygen or sulfur atom, andb) from 1 to 100% by weight, based on the pigment, of a nitroxyl compound or of an acid-addition salt thereof.These pigment compositions are distinguished by excellent light stability and weathering resistance.Type: GrantFiled: December 22, 1993Date of Patent: February 14, 1995Assignee: Ciba-Geigy CorporationInventor: Laurent Chassot
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Patent number: 5378276Abstract: Diketopyrrolopyrroles of formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently of one another hydrogen, chloro, C.sub.1 -C.sub.4 alkyl, methoxy, phenyl, cyano or a group--X.sub.1 --V--X.sub.2 --T--A,in which at least one of R.sub.1, R.sub.2, R.sub.3 or R.sub.Type: GrantFiled: February 17, 1994Date of Patent: January 3, 1995Assignee: Ciba-Geigy CorporationInventors: Laurent Chassot, Gary Wooden
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Patent number: 5322944Abstract: Process for preparing enantiomers of general formula (I): ##STR1## where Z, R.sub.1, R.sub.2, R.sub.3 and n are defined in the description. The compounds obtained according to the invention are useful as medicinal products.Type: GrantFiled: June 30, 1992Date of Patent: June 21, 1994Assignee: Adir et CompagnieInventors: Gerald Guillaumet, Claude Fugier, Jean-Claude J. Souvie, Gerard Adam, Pierre Renard, Daniel-Henri Caignard
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Patent number: 5276053Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.Type: GrantFiled: October 6, 1992Date of Patent: January 4, 1994Assignee: Warner-Lambert CompanyInventor: Graham Johnson
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Patent number: 5219879Abstract: The present invention relates to novel substituted 15-oxa-, 15-thia-, and 15-aza- dihydrolanosterols, to pharmaceutical compositions containing such compounds, and to methods of using these compounds to suppress the activity of 3-hydroxy-3- methylglutaryl coenzyme A reductase (HMGR), an enzyme which is important in cholesterol biosynthesis. The overall effect of these heterocyclic lanosterol analogs is to decrease cholesterol formation, thereby resulting in lower serum cholesterol levels in mammals, and impaired ergosterol synthesis in fungi.Type: GrantFiled: March 1, 1991Date of Patent: June 15, 1993Assignee: Du Pont Merck Pharmaceutical CompanyInventors: Soo S. Ko, James M. Trzaskos
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Patent number: 5204467Abstract: Photopolymerizable compositions containing photoinitiator systems that absorb in the visible are disclosed.Type: GrantFiled: December 20, 1991Date of Patent: April 20, 1993Assignee: E. I. Du Pont de Nemours and CompanyInventor: William K. Smothers
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Patent number: 5180736Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.Type: GrantFiled: May 17, 1991Date of Patent: January 19, 1993Assignee: Warner-Lambert CompanyInventor: Graham Johnson
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Patent number: 5162545Abstract: Malonic acid dyes capable of forming polycondensation products have the formula ##STR1## where R.sup.1 and R.sup.2 are each independently of the other hydroxyl, C.sub.1 -C.sub.6 -alkoxy, chlorine or bromine,R.sup.3 is hydrogen or C.sub.1 -C.sub.6 -alkyl,A is C.sub.1 -C.sub.20 -alkylene which may be interrupted by oxygen atoms or by imino or C.sub.1 -C.sub.4 -alkylimino groups, andChr is the radical of a chromophore derived from an anthraquinone, perylene, disazo or trisazo dye or else, when R.sup.3 is C.sub.1 -C.sub.6 -alkyl, from a monoazo dye.Type: GrantFiled: October 12, 1990Date of Patent: November 10, 1992Assignee: BASF AktiengesellschaftInventors: Karl-Heinz Etzbach, Karin H. Beck, Gerhard Wagenblast
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Patent number: 5116958Abstract: Disperse dyes, which produce dyeings of excellent thermomigration fastness, consisting of a chromophore and a lactam or oxime radical which detaches on heating to leave an isocyanate or isothiocyanate group, which reacts with a suitable group in the environment. The disclosed dyes are described by the formula ##STR1## where F is the radical of a dye which is free of water-solubilizing groups,B is a bridge member or a direct bond,Z is O or S andV is the radical of a group H--V, where H--V is an oxime of the formula ##STR2## or a lactam of the formula ##STR3## in which R.sup.1 and R.sup.2 are each independently of the other substituted or unsubstituted alkyl or aryl, orR.sup.1 and R.sup.2 together with the carbon atom linking them form a cycloaliphatic ring,R is hydrogen or alkyl andn is an integer from 4 to 11.Type: GrantFiled: January 5, 1990Date of Patent: May 26, 1992Assignee: Ciba-Geigy CorporationInventors: Peter Liechti, Martin Trottmann
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Patent number: 5071853Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.Type: GrantFiled: February 27, 1990Date of Patent: December 10, 1991Inventors: Christopher F. Bigge, Sheryl J. Hays, Graham Johnson, Perry M. Novak, Daniel F. Ortwine
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Patent number: 4904796Abstract: Blue anthraquinonoid disperse dyes are prepared by reacting a 1-amino-4-nitroanthraquinonecarboxamide (II) with a cyanide in an aqueous medium in the presence of hydroxyl ion acceptors at above 20.degree. C. by a process in which the reaction is carried out in water at a pH of from 7.5 to 10.5 and in the presence of one or more quaternary ammonium salts at from 60.degree. to 100.degree. C.The process gives disperse dyes which are similar to C.I. Disperse Blue 87 and have similar color properties in high yields by an environmentally compatible process, the said disperse dyes having excellent properties.Type: GrantFiled: February 10, 1988Date of Patent: February 27, 1990Assignee: BASF AktiengesellschaftInventors: Eberhard Michaelis, Helmut Hoch