Chalcogen Attached Indirectly To The Five-membered Hetero Ring By Acyclic Nonionic Bonding Patents (Class 548/547)
  • Patent number: 5962504
    Abstract: Compounds of formula I: ##STR1## wherein R.sub.1 and R.sub.2 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are PKC activators and are useful for treating diseases, such as, for example, cancer. Also disclosed are pharmaceutical compositions comprising compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: October 5, 1999
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Shaomeng Wang, Lixin Qiao
  • Patent number: 5959122
    Abstract: A process for making derivatized polymers of maleic anhydride containing maleamic acid and its corresponding cyclic imide repeat units, in alcohol solution, at a temperature of about 60-160.degree. C., during a reaction period of about 1-25 hours. The product is a polymer having a predetermined ratio of the above repeat units.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: September 28, 1999
    Assignee: ISP Investments Inc.
    Inventors: Herbert W. Ulmer, John A. Katirgis, Timothy Gillece
  • Patent number: 5954843
    Abstract: Aminocarbamates of polyalkyl or polyalkenyl N-hydroxyalkyl succinimides having the formula: ##STR1## or a fuel soluble salt thereof; wherein R is a polyalkyl or polyalkenyl group having an average molecular weight in the range of about 450 to about 5,000;n is an integer from 2 to 5; andA is a polyamine moiety having at least one basic nitrogen atom, wherein the polyamine is connected to he carbonyl group through one of its nitrogen atoms to form a carbamate linkage.The compounds of formula I are useful as fuel additives for the prevention and control of engine deposits.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: September 21, 1999
    Assignee: Chevron Chemical Company LLC
    Inventor: Richard E. Cherpeck
  • Patent number: 5948922
    Abstract: Compounds containing two cyclic hydrocarbon moieties which are substituted to provide crosslinking functionality and which are linked to each other by secondary or tertiary oxycarbonyl containing moiety are basis for compositions which are cured to provide cured thermosets for encapsulation and underfill for electronic components that are thermally decomposable to allow repair, replacement, recovery or recycling of operative electronic components from assemblies that are inoperative.
    Type: Grant
    Filed: February 20, 1997
    Date of Patent: September 7, 1999
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Christopher K. Ober, Hilmar Koerner
  • Patent number: 5929251
    Abstract: Process for the preparation of carboxylic acid succinimidyl esters by reaction of N-hydroxysuccinimide with a carboxylic acid and a halophosphoric acid ester of the formula ##STR1## in which R.sub.1 and R.sub.2 are identical or different and are a C.sub.2 - to C.sub.6 -alkyl radical or a phenyl radical, or R.sub.1 and R.sub.2 together form a C.sub.6 -aryl radical, in the presence of a base in a diluent at a temperature of 0.degree. C. up to 100.degree. C. and isolation of the corresponding carboxylic acid succinimidyl ester.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: July 27, 1999
    Assignee: DSM Fine Chemicals Austria GmbH
    Inventors: Peter Pochlauer, Wolfram Hendel, Christian Burger, Anita Lamplmayr, Harald Poschko, Antonia Praus, Gerald Summer
  • Patent number: 5912359
    Abstract: The invention relates to novel dimaleinimido-substituted dihydroxyalkanes, to a process for their preparation as well as to their use as cross-linking reagents, e.g. in analytical methods. A disadvantage of the cleavable bismaleinimido derivatives used so far, which react with SH groups, is that the subsequent cleavage of the cross-linking reagents from the proteins must take place in acidic or alkaline media. The objective of the invention is to prepare novel cleavable cross-linking reagents which react with SH groups or proteins and which form cross-links which can be cleaved under mild conditions not requiring strongly acidic or basic media. This objective is sought through the preparation and use of dimaleinimido-substituted dihydroxyalkanes having the general formula I ##STR1## where n=1 to 6, preferably 1 or 2.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: June 15, 1999
    Assignees: Forschungszentrum Julich GmbH, Forschungsverbund Berlin E.V.
    Inventors: Paul J. Bauer, Volker Hagen
  • Patent number: 5892057
    Abstract: The salt of a sulfonated succinic acid is cyclized, then converted to novel sulfonated hydroxamic acids by reaction with hydroxylamine (which is added or formed in situ), and the novel hydroxamic acid is then cyclized to the sulfo-N-hydroxysuccinimide salt. This synthetic procedure is simple, direct, and more rapid than present procedures for synthesis of the succinimide. Novel sulfo-hydroxamic acid intermediates are formed during this procedure.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: April 6, 1999
    Assignee: Pierce Chemical Company
    Inventors: Marty Carey Wilkes, Martin Lee Bremmer
  • Patent number: 5886194
    Abstract: This invention describes hydroxyamino-derivatized polymers of .alpha.-olefin-maleic anhydride in the form of their maleimide, maleamic acid and .alpha.-olefin-maleic anhydride half-acid/half ester or full acid repeat units process for making same. The polymers are made by reacting an .alpha.-olefin-maleic anhydride, half-acid/half-ester or full acid with a hydroxy containing .alpha.-unsubstituted primary amine in aqueous or aqueous alcoholic solution at a temperature of about 60.degree.-160.degree. C. during a reaction period of about 1-25 hours.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: March 23, 1999
    Assignee: ISP Investments Inc.
    Inventors: Herbert W. Ulmer, Timothy Gillece, John A. Katirgis
  • Patent number: 5877297
    Abstract: Boron compound completing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents. These reagents, including those shown as General Formula CII may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain up to about 0 to 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide and disulfide moieties, and a polyethylene glycol chain of from 3 to 12 carbon equivalents in length; group R.sub.2 is one of an alkyl and a methylene with an electronegative moiety; and BAS is a biologically active species.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: March 2, 1999
    Assignee: Prolinx, Inc.
    Inventors: Mark L. Stowolitz, Robert J. Kaiser, Kevin P. Lund
  • Patent number: 5872261
    Abstract: A process is described for rapid preparation of pure sulfo-N-hydroxysuccinimides. The process may comprise the steps of:a) esterifying a sulfo-succinic acid to form a diester first product, andb) reacting said diester first product with hydroxylamine to form a sulfo-N-hydroxy succinimide.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: February 16, 1999
    Assignee: Pierce Chemical Company
    Inventors: Martin Lee Bremmer, Marty Carey Wilkes
  • Patent number: 5872224
    Abstract: Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula CIV, and General Formula CVI. In one embodiment, the reagent of General Formula CIV may be used to form a complex with a boron compound, such as a complex shown in General Formula CVI. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain of up to about 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide and disulfide moieties, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; group R.sub.3 is selected from one of an H, an alkyl, and a methylene or ethylene moiety with an electronegative substituent; and BAS and BAS* are biologically active species.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 16, 1999
    Assignee: Prolinx, Inc.
    Inventors: Mark L. Stolowitz, Robert J. Kaiser, Kevin P. Lund
  • Patent number: 5869623
    Abstract: Boron compound complexing reagents, intermediate reagents of those reagents, and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula II may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain of up to about 6 carbon equivalents in length, an unbranched saturated or unsaturated chain from about 6 to 18 carbon equivalents in length with at least one intermediate amide or disulfide moieties, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; group R.sub.2 is one of an alkyl and a methylene group with an electronegative moiety; and BAS is a biologically active species.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 9, 1999
    Assignees: Systemix, Prolinx, Inc.
    Inventors: Mark L. Stolowitz, Robert J. Kaiser, Kevin P. Lund, Steven M. Torkelson
  • Patent number: 5869695
    Abstract: A process for making derivatized polymers of maleic anhydride containing maleamic acid and its corresponding cyclic imide repeat units, in alcohol solution, at a temperature of about 60.degree.-160.degree. C., during a reaction period of about 1-25 hours. The product is a polymer having a predetermined ratio of the above repeat units.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: February 9, 1999
    Assignee: ISP Investments Inc.
    Inventors: Herbert W. Ulmer, John A. Katirgis
  • Patent number: 5859210
    Abstract: Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula IV and General Formula VI. In one embodiment, the reagent of General Formula IV may be used to form a complex with a boron compound, such as a complex shown in General Formula VI. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain of up to about 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide or disulfide moieties, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; group R.sub.3 is selected from one of an H, an alkyl, and a methylene or ethylene moiety with an electronegative substituent; and BAS and BAS* are biologically active species.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: January 12, 1999
    Assignees: Prolinx, Inc., Systemix
    Inventors: Mark L. Stowolitz, Robert J. Kaiser, Kevin P. Lund, Steven M. Torkelson
  • Patent number: 5851966
    Abstract: Compositions of matter for use in oils and fuels are disclosed. The compositions arise from reaction products (C) formed by reacting substituted carboxylic acylating agents (A) with carboxylic reactants (B). The reactant (A) is usually a polyolefin substituted succinic anhydride or acid which is reacted with (B). (B) is usually a glyoxylic compound. Carboxylic reaction products (C) may further be reacted to form succinimide dispersants, esters or other derivatives. Products (C) may also be reacted with an .alpha.-.beta. unsaturated compound to form second carboxylic reaction products.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: December 22, 1998
    Assignee: The Lubrizol Corporation
    Inventors: Mark R. Baker, Paul E. Adams, Jeffry G. Dietz
  • Patent number: 5847192
    Abstract: Boron compound complexing reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula I and General Formula II may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: December 8, 1998
    Assignees: Prolinx, Inc., Systemix
    Inventors: Mark L. Stolowitz, Robert J. Kaiser, Kevin P. Lund, Steven M. Torkelson
  • Patent number: 5837878
    Abstract: Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula CIII, General Formula CIV, and General Formula CVI. In one embodiment, the reagents of General Formula CIII may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula CIV. The reagent of General Formula CIV may be used to form a complex with a boron compound, such as a complex shown in General Formula CVI.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: November 17, 1998
    Assignee: Prolinx, Inc.
    Inventors: Mark L. Stolowitz, Robert J. Kaiser, Kevin P. Lund
  • Patent number: 5824805
    Abstract: Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: October 20, 1998
    Inventors: Dalton King, Raymond A. Firestone, Pamela Trail
  • Patent number: 5789491
    Abstract: Fluorinated imides useful for imparting repellency of low surface tension fluids to thermoplastic polymers of formulae ##STR1## wherein R.sub.1 is F(CF.sub.2).sub.x --(CH.sub.2).sub.m, or F(CF.sub.2).sub.x SO.sub.2 N(R.sub.5)(CH.sub.2)p wherein x is from about 4 to about 20, m is from about 2 to about 6, p is from 1 to about 12, and R.sub.5 is an alkyl radical of from 1 to about 4 carbons;R.sub.2 is a linear, branched or cyclic alkylene or poly(oxyalkylene) hydrocarbon group having from about 2 to about 15 carbons;R.sub.3 is selected from the group consisting of F(CF.sub.2).sub.x --(CH.sub.2).sub.m, F(CF.sub.2).sub.x --(CH.sub.2).sub.m --OC(O)--(CH.sub.2).sub.n, and F(CF.sub.2).sub.x SO.sub.2 N(R.sub.5)(CH.sub.2).sub.p OC(O)(CH.sub.2).sub.nwherein x is from about 4 to about 20, m is from about 2 to about 6, n is about 2 to about 12, p is from 1 to about 12, and R.sub.5 is an alkyl radical of from 1 to about 4 carbons;R.sub.4 is an alkyl or alkenyl group of from about 4 to about 20 carbons, andR.sub.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: August 4, 1998
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Theodor Arthur Liss, Kimberly Gheysen Raiford, Edward James Greenwood
  • Patent number: 5780645
    Abstract: A process for the alkylation of imides wherein the imides are reacted with a dialkyl carbonate, in the liquid state, at a temperature of between 100.degree. C. and 250.degree. C. and at a pressure of between 0 and 60 atmospheres in the presence of a basic catalyst. The dialkyl carbonate reagents are not very toxic and are thermally stable and their use as alkylation agents makes it possible to produce waste products with a negligible saline content.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: July 14, 1998
    Assignee: Enichem S.p.A.
    Inventors: Marcello Notari, Franco Mizia, Franco Rivetti
  • Patent number: 5777148
    Abstract: Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula I and General Formula II may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: July 7, 1998
    Assignee: Prolinx, Inc.
    Inventors: Mark L. Stowolitz, Robert J. Kaiser, Kevin P. Lund
  • Patent number: 5770731
    Abstract: A prodrug of the general formula FTLi-(PRT)m, where m is an integer from 1 to 5; FTLi is a ras inhibitor such as a farnesyltransferase inhibitor compound, such as Ia, Ib, Ic; and PRT represents m protecting groups or a precursor thereof, such as compound XVI, which are capable of being cleaved from the ras inhibitor by the action of a enzyme.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: June 23, 1998
    Assignee: Cancer Research Campaign Technology Limited
    Inventors: Caroline Joy Springer, Richard Marais
  • Patent number: 5756762
    Abstract: The present invention relates to a novel enantiospecific processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and pharmaceutically acceptable salts thereof, which is useful as an irreversible inhibitor of GABA-T, to novel intermediates thereof, and a process for preparing an intermediate thereof.
    Type: Grant
    Filed: January 9, 1997
    Date of Patent: May 26, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventor: H. Michael Kolb
  • Patent number: 5744627
    Abstract: Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula III, General Formula IV, and General Formula VI. In one embodiment, the reagents of General Formula III may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula IV. The reagent of General Formula IV may be used to form a complex with a boron compound, such as a complex shown in General Formula VI.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: April 28, 1998
    Assignees: Prolinx, Inc., Systemix
    Inventors: Mark L. Stowolitz, Robert J. Kaiser, Kevin P. Lund, Steven M. Torkelson
  • Patent number: 5734063
    Abstract: The present invention provides a method for preparation of a compound of the formula (I) useful as a fog restrainer for a silver halide light-sensitive material, especially for a heat-developing light-sensitive material and a synthetic intermediate for the fog restrainer. The method makes it possible to obtain the fog restrainer in good yield and in short steps. ##STR1## wherein, R.sup.1 is alkyl, cycloalkyl, or aryl, R.sup.2 and R.sup.3 are hydrogen atom or alkyl, R.sup.4 is hydrogen atom or acyl, and R.sup.1 and R.sup.4 may be bonded together to form 5- or 6-membered ring.
    Type: Grant
    Filed: October 24, 1996
    Date of Patent: March 31, 1998
    Assignee: Fuji Photo Film Co.,Ltd.
    Inventors: Katsuyoshi Yamakawa, Tadahisa Sato
  • Patent number: 5728588
    Abstract: A surface of specific reactivity is formed by adsorbing a modified block polymeric surfactant of the Pluronic-type, i.e., containing pendant poly(ethylene oxide) blocks attached at an end to poly(propylene oxide) center blocks and with specifically reactive groups at the unattached ends of the poly(ethylene oxide) blocks, upon a hydrophobic surface.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: March 17, 1998
    Inventors: Karin Maria Elisabet Caldwell, Per Jan Erik Carlsson, Jenq-Thun Li
  • Patent number: 5703208
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 30, 1997
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Robert John Ardecky, Ruth Foelsche Nutt, William Charles Ripka, David C. Rowley, Marguerita S. L. Lim-Wilby, Terence Kevin Brunck
  • Patent number: 5688825
    Abstract: Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. The disclosed method and novel compounds can be used to reduce pain in an individual or animal suffering from pain, reducing nausea in an individual undergoing chemotherapy, for example cancer chemotherapy, suppressing appetite in an individual, reducing intraocular pressure in the eye of an individual or animal suffering from glaucoma and suppressing the immune system in an individual with an organ transplant.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: November 18, 1997
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Sonyan Lin, William Adam Hill
  • Patent number: 5681963
    Abstract: Fluorinated imides useful for imparting repellency of low surface tension fluids to thermoplastic polymers of formulae ##STR1## wherein R.sub.1 is F(CF.sub.2).sub.x --(CH.sub.2).sub.m, or F(CF.sub.2).sub.x SO.sub.2 N(R.sub.5) (CH.sub.2) .sub.p wherein x is from about 4 to about 20, m is from about 2 to about 6, p is from 1 to about 12, and R.sub.5 is an alkyl radical of from 1 to about 4 carbons;R.sub.2 is a linear, branched or cyclic alkylene or poly(oxyalkylene) hydrocarbon group having from about 2 to about 15 carbons;R.sub.3 is selected from the group consisting of F(CF.sub.2).sub.x --(CH.sub.2).sub.m, F(CF.sub.2).sub.x --(CH.sub.2).sub.m --OC(O)--(CH.sub.2).sub.n, and F(CF.sub.2).sub.x SO.sub.2 N(R.sub.5)(CH.sub.2).sub.p OC(O)(CH.sub.2).sub.n wherein x is from about 4 to about 20, m is from about 2 to about 6, n is about 2 to about 12, p is from 1 to about 12, and R.sub.5 is an alkyl radical of from 1 to about 4 carbons;R.sub.4 is an alkyl or alkenyl group of from about 4 to about 20 carbons, andR.sub.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: October 28, 1997
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Theodor Arthur Liss
  • Patent number: 5658940
    Abstract: Novel succinimides and maleimides are inhibitors of tumor necrosis factor .alpha. and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is methyl 3-(3',4',5',6'-tetrahydrophthalimido)-3-(3",4"-dimethoxyphenyl)propionate.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: August 19, 1997
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Mary Shire
  • Patent number: 5654477
    Abstract: The present invention relates to a novel enantiospecific processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and pharmaceutically acceptable salts thereof, which is useful as an irreversible inhibitor of GABA-T, to novel intermediates thereof, and a process for preparing an intermediate thereof.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: August 5, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventor: H. Michael Kolb
  • Patent number: 5620486
    Abstract: A fuel composition comprising a major amount of hydrocarbons boiling in the gasoline or diesel range and an effective detergent amount of a compound of the formula: ##STR1## wherein R is a hydrocarbyl group having an average molecular weight of about 400 to 5,000; andR.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, hydroxy, --CO.sub.2 H, --NO.sub.2, and --NR.sub.3 R.sub.4, wherein R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl of 1 to 6 carbon atoms; provided that R.sub.1 and R.sub.2 cannot both be hydrogen.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: April 15, 1997
    Assignee: Chevron Chemical Company
    Inventor: Richard E. Cherpeck
  • Patent number: 5614638
    Abstract: New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, ##STR2## --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-- or ##STR3## R.sub.1, R.sub.1 ' and R.sub.2 are the same or different and are hydrogen, alkyl or hydroxyalkyl.Hydroxyalkyl refers to such alkyl groups having 1 or more hydroxy groups. Preferred hydroxyalkyl groups include: ##STR4## R.sub.3 and R.sub.4 are the same or different and are hydrogen, methyl or --CH.sub.2 CH.sub.2 OH; R.sub.5 is hydrogen, alkyl, --CH.sub.2 CH.sub.2 OH, CH.sub.2 OH or OH and R.sub.6 is alkyl, --CH.sub.2 CH.sub.2 OH, CH.sub.2 OH, OH or hydrogen and may be the same or different than R.sub.5 and m is zero or one, with the proviso that no methylene or methine carbon atom of the heterocyclic ring is attached to both a nitrogen and an oxygen atom with the additional proviso that when Y is a single bond, m is not zero.
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: March 25, 1997
    Assignee: Bracco International B.V.
    Inventors: Ramachandran S. Ranganathan, Thangavel Arunchalam, Edmund R. Marinelli, Radhakrishna K. Pillai
  • Patent number: 5607963
    Abstract: Maleimide pesticides having enhanced efficacy represented by the formula (I), ##STR1## wherein X represents a halogen atom or a hydrogen atom, and R represents an alkyl group a cycloalkyl or haloalkyl group, a pesticidal composition containing the same as an active ingredient, and a process for producing the same.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 4, 1997
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Kazunori Tsushima, Takashi Furukawa, Tomonori Iwasaki, Takao Ishiwatari, Mikako Nakamachi
  • Patent number: 5608057
    Abstract: Proposed are an N-(.alpha.-acyloxyethyl) compound, e.g., (N-(.alpha.-acetoxyethyl)-2-pyrrolidone, which is a novel compound and can be converted into an industrially very important N-vinyl compound, e.g., N-vinyl-2-pyrrolidone, by a thermal decomposition reaction under relatively mild conditions as well as a method for the preparation of such an N-(.alpha.-acyloxyethyl) compound. The N-(.alpha.-acyloxyethyl) compound can be synthesized in a high yield by the addition reaction of an NH group-containing compound, e.g., 2-pyrrolidone, with a vinyl carboxylate, e.g., vinyl acetate, in the presence of an alkaline compound such as alkali metal hydroxides.
    Type: Grant
    Filed: August 23, 1995
    Date of Patent: March 4, 1997
    Assignee: Shin-Etsu Vinyl Acetate Co., Ltd.
    Inventors: Yoshihiro Honma, Shozo Tanaka, Mitsuyoshi Oshima, Soji Tanioka, Fumiaki Kawamoto
  • Patent number: 5602134
    Abstract: The present invention relates to novel positive inotropic and lusitropic compounds of formula ##STR1## the pharmaceutical acceptable acid addition salts thereof and the stereochemically isomeric forms thereof wherein L is a radical of formula --O-Alk-(NH).sub.p -C(.dbd.O)-R.sup.1, pharmaceutical compositions thereof, methods of preparing said compounds and intermediates in the preparation thereof.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: February 11, 1997
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Eddy J. E. Freyne, Alfons H. M. Raeymaekers
  • Patent number: 5594089
    Abstract: Thermomechanical and thermo-oxidative stabilities in heterocycle or heterocycle sulfone resin composites are improved by forming four crosslinks at each addition polymerization site in the backbone of the resin using crosslinking functionalities.
    Type: Grant
    Filed: October 21, 1994
    Date of Patent: January 14, 1997
    Assignee: The Boeing Company
    Inventors: Hyman R. Lubowtiz, Clyde H. Sheppard
  • Patent number: 5554769
    Abstract: The solvent-resistance and thermal stability of polyamideimides of the general formulae: ##STR1## is improved by capping the amideimides with a crosslinking functionality (Y) containing a residue selected from the group of: ##STR2## wherein R.sub.1 =lower alkyl, lower alkoxy, aryl, aryloxy, substituted alkyl, substituted aryl (either including hydroxyl or halo-substituents), halogen, or mixtures thereof;j=0, 1, or 2;G=--CH.sub.2 --, --O--, --S--, --SO.sub.2 --, --SO--, --CO--, --CHR--, or --C(R).sub.2 --;R=hydrogen, lower alkyl, or phenyl;T=methallyl or allyl;Me=methyl;R.sub.2 =a trivalent organic radical; andR.sub.3 =a divalent organic radical.The amideimide oligomers may be linear or multidimensional, and can be processed into blends, prepregs, or composites. Methods of making these amideimides and intermediates useful in the syntheses are also described. One such intermediate has the general formula:Y.sub.i --CONH--R.sub.3 --NH.sub.2and is the focus of the present application.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 10, 1996
    Assignee: The Boeing Company
    Inventors: Clyde H. Sheppard, Hyman R. Lubowitz
  • Patent number: 5541341
    Abstract: The present invention relates to a new class of carbohydrate based nonionic surfactant, i.e., alkyl and alkenyl glycasuccinimide, and a process for their manufacture.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: July 30, 1996
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventors: Robert Vermeer, Van Au, Bijan Harichian
  • Patent number: 5536434
    Abstract: This invention relates to imido-derivative peroxycarboxylic acids having the formula I: ##STR1## wherein R and R.sub.1, which may be the same or different, represent hydrogen atoms, alkyl groups, or, taken together with the carbon atoms to which they are linked, give rise to a cyclic aliphatic ring, all of them being optionally substituted; the . . . symbol indicates a simple or an olefinic bond; R.sub.2 represents a hydrogen atom, an alkyl group, or an OH group, and n is an integer different from 0; the process for their preparation and their use as bleaching agents.
    Type: Grant
    Filed: October 20, 1989
    Date of Patent: July 16, 1996
    Assignee: Ausimont S.p.A.
    Inventors: Carlo Venturello, Claudio Cavallotti, Elena Bencini, Maria A. Sasso
  • Patent number: 5514815
    Abstract: Novel succinimide derivatives of formula I!: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula:>N--R.sup.3or one of R.sup.1 and R.sup.2 is lower alkoxy, and the other is group of the formula: --NHR.sup.3, in which R.sup.3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.
    Type: Grant
    Filed: March 18, 1993
    Date of Patent: May 7, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Tameo Iwasaki, Takashi Nishitani, Akio Ohtani, Masanori Inamasu
  • Patent number: 5507843
    Abstract: The present invention is directed to the use of multiple cyclic nitrogen-containing alkoxylate compounds as additives in fuel compositions. The invention is also directed to the use of these multiple cyclic nitrogen-containing alkoxylate compounds for decreasing intake valve deposits, controlling octane requirement increases and reducing octane requirement. The invention is further directed to a class of multiple cyclic nitrogen-containing alkoxylate compounds.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: April 16, 1996
    Assignee: Shell Oil Company
    Inventors: Jiang-Jen Lin, Pen-Chung Wang, Sarah L. Weaver
  • Patent number: 5502206
    Abstract: The liquid-crystalline organosiloxanes containing, per molecule, at least one Si--C-bonded chiral tartarimide radical of the formula ##STR1## in which M, A.sup.5 and k are as defined in claim 1, can be employed as chiral filter materials, for decorative purposes and in optical elements.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: March 26, 1996
    Assignee: Consortium fu/ r elektrochemische Industrie GmbH
    Inventors: Ingo P. Zahn, Franz-Heinrich Kreuzer, Hans-Peter Weitzel
  • Patent number: 5491262
    Abstract: Bis{[1-(2-A-2-B)ethenyl]} [2-R.sup.2 -4-X-phenyl- or 1-(2-R.sup.2 -4-X-phenyl) ethenyl]methanes useful as color formers, particularly in transfer imaging, pressure sensitive and thermal-responsive carbonless duplicating systems, are prepared by the interaction of two molecular proportions of the corresponding 1-A-1-B-ethene with the appropriate 2-R.sup.2 -4-X-phenyl-(CH.dbd.CH).sub.n --CHO presence of an acidic catalyst.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: February 13, 1996
    Assignee: Hilton Davis Chemical Co.
    Inventor: William M. Hung
  • Patent number: 5475021
    Abstract: The present invention includes N-substituted maleimides (1(H)-Pyrrole-2,5-dione (Maleimide) analogs and succinimides which act as potent nonsteroidal anti-inflammatory drugs and are capable of dual inactivation or selective inactivation of the cyclooxygenase and the peroxidase activities of prostaglandin endoperoxide synthase (PGHS).
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: December 12, 1995
    Assignee: Vanderbilt University
    Inventors: Lawrence J. Marnett, Amit S. Kalgutkar
  • Patent number: 5464549
    Abstract: The dispersants are formed by reacting (a) at least one dispersant having at least one primary or secondary amino group and/or at least one hydroxyl group, with (b) at least one polyolefinic compound substituted at each terminal position by a succinic group. Suitable substances for use as reactant (b) include compounds derived from at least one telechelic compound having up to 5000 carbon atoms and at least two terminal methylene groups by reaction with maleic anhydride or the like. The products are deemed to be effective dispersant/detergents for use in fuels and lubricants. In fuels the products are deemed to exhibit the property of inhibiting and/or reducing deposit formation such as intake valve deposits. In crankcase lubricants, the products are deemed to provide desirable viscosity index improving properties.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: November 7, 1995
    Assignee: Ethyl Corporation
    Inventor: John F. Sieberth
  • Patent number: 5453517
    Abstract: The invention relates to fluorescent and/or reactive derivatives of 1,2-bis-(2-aminophenoxyethane)-N,N,N',N'-tetraacetic acid (BAPTA) according to the formula: ##STR1## where at least one of W and X is a functional group, with or without a spacer, that terminates in an alcohol or phenol, a thiol, a haloacetamide, an alkyl halide, an amine or aniline, a carboxylic acid, an anhydride, an isocyanate, an isothiocyanate, a maleimide, or an activated ester. The BAPTA-like molecule may be further substituted, one or more times, by additional functional groups with or without spacers or by CH.sub.3, NO.sub.2, CF.sub.3, F, Cl, Br, I, or carboxylic acid derivatives or pharmaceutically acceptable salts thereof, or by indolyl or benzofuran fluorophores. The functional groups allow for subsequent covalent attachment of one or more oxygen heterocycle fluorophores (e.g. fluorescein, coumarin, rhodamine); or polymolecular assemblies (e.g.
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: September 26, 1995
    Assignee: Molecular Probes, Inc.
    Inventors: Michael A. Kuhn, Richard P. Haugland
  • Patent number: 5453516
    Abstract: A process for preparing 5-membered ring heterocycles of the general formula I ##STR1## where R.sup.1 is methyl or hydroxyethyl,R.sup.2,R.sup.3,R.sup.4,R.sup.5 and R.sup.6 are hydrogen, C.sub.1 - to C.sub.12 -alkyl, C.sub.2 - to C.sub.12 -alkenyl, aryl, C.sub.3 - to C.sub.8 -cycloalkyl, C.sub.1 - to C.sub.12 -alkoxy, halogen, C.sub.2 - to C.sub.20 -alkoxycarbonylalkyl, C.sub.2 - to C.sub.20 -alkylcarbonyloxy, formyl, C.sub.2 - to C.sub.20 -formylalkyl, benzoyl or --CH(OR.sup.3)(OR.sup.5), or R.sup.3 and R.sup.5 together are a C.sub.2 - to C.sub.7 -alkylene chain which is unsubstituted or monosubstituted to pentasubstituted by R.sup.4 or a .dbd.CH--CH.dbd.CH--CH.dbd. unit which is unsubstituted or monosubstituted to tetrasubstituted by R.sup.4,X is oxygen or N--R.sup.4by reacting 5-membered ring heterocycles of the general formula II ##STR2## where R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and X have the abovementioned meanings and Y is hydrogen, acetyl or C.sub.2 - to C.sub.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: September 26, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Rolf Fischer, Rolf Pinkos
  • Patent number: 5439603
    Abstract: A lubricating oil soluble compound suitable for use as a dispersant additive is obtainable by reacting at elevated temperature an epoxyacrylate with a dispersant having at least one reactive nitrogen-containing moiety.Intermediates of the general formula IV ##STR1## where Y' is a group derived from the reaction of the epoxyacrylate with reactive nitrogen-containing moieties (ie primary or secondary amines) are novel.The process for preparing the lubricating oil soluble compounds can be a one step or multistep process.Lubricating oil compositions comprise a major proportion of lubricating oil and a minor proportion of the lubricating oil soluble compounds.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: August 8, 1995
    Assignee: BP Chemicals (Additives) Limited
    Inventor: William D. Carlisle
  • Patent number: 5415926
    Abstract: In a process for the preparation of N-alkylol amide monomers wherein a polymerizable amide is reacted with an aldehyde, the improvement which comprises adjusting the pH of the resulting N-alkylol amide monomer to pH 10-11 and adding thereto an alkali or alkali earth metal borohydride at a temperature of -10.degree. to 20.degree. C. so as to convert the residual free aldehyde in the equilibrium mixture to the corresponding alcohol.
    Type: Grant
    Filed: February 25, 1993
    Date of Patent: May 16, 1995
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: John C. Leighton, Rama S. Chandran