Chalcogen Attached Indirectly To The Five-membered Hetero Ring By Acyclic Nonionic Bonding Patents (Class 548/547)
  • Patent number: 5410069
    Abstract: A polymerzable compound represented by the general formula (1) X--R.sub.1 --Y where X is un unsaturated imide group having substituents R.sub.2 and R.sub.3, or an itacon imide group where R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, a lower alkyl group and an aromatic group having a substituent p which is hydrogen, a lower alkyl group, or an alkoxy group, and Y is a styryl group, and R.sub.1 is a divalent organic group.The polymerizable compounds is excellent in formability, and find a wide variety of applications because they have functional groups different in reactivity from each other and hence allow the curing conditions to control. The cured polymers are excellent in thermal durability, mechanical properties and electrical properties, making it possible to achieve higher performance, higher reliability, highly compact and lower weight of electric apparatuses and electronic parts.
    Type: Grant
    Filed: December 8, 1992
    Date of Patent: April 25, 1995
    Assignee: Hitachi, Ltd.
    Inventors: Shin Nishimura, Yoshinori Kawai, Satoru Amou, Akira Nagai, Masahiro Suzuki, Akio Takahashi, Akio Mukoh
  • Patent number: 5399673
    Abstract: Compounds containing at least one alkenyl group, at least one maleimide group and at least one rodlike mesogenic moiety are prepared by reacting one or more aminophenols containing one or more rodlike mesogenic moieties with a stoichiometric quantity of a maleic anhydride per amine group of said aminophenol and then alkenylating the resulting phenolic functional maleimide.
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: March 21, 1995
    Assignee: The Dow Chemical Company
    Inventor: Robert E. Hefner, Jr.
  • Patent number: 5384055
    Abstract: A lubricant additive composition and method for production is disclosed comprising the adduct of an olefinic oligomer and an enophile, said olefinic oligomer comprising the product of the oligomerization of C.sub.2 to C.sub.24 alpha-olefin feedstock, or mixtures thereof, under oligomerization conditions in contact with a reduced valence state Group VIB metal catalyst on porous support. Maleic anhydride is a preferred enophile. The maleic anhydride adduct is reacted with polyamines such as tetraethylene pentamine to form the corresponding alkenyl bis-succinimide.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: January 24, 1995
    Assignee: Mobil Oil Corporation
    Inventor: Henry Ashjian
  • Patent number: 5376529
    Abstract: This invention relates to novel methods for the release of nucleic acids from cells in complex biological samples or specimens to prepare and make available the nucleic acid material present for a hybridization assay or for extraction. Novel methods for hybridization of nucleic acids are also presented. In particular methods are described for isolating nucleic acid from a sample containing a complex biological mixture of nucleic acid and non-nucleic acids wherein the sample is combined with a hybridization medium comprising a lactam which promotes and enables nucleic acid pairing when complementary nucleic acid is introduced. The lactam is preferably about 5 to about 70% of the hybridization medium and is most preferably 2-pyrrolidone, N-ethyl-2-pyrrolidone, N-cyclohexyl-2-pyrrolidone, N-dodecyl-2-pyrrolidone, N-methyl-2-pyrrolidone, N-hydroxyethyl-2-pyrrolidone, N-methyl-2-piperidone, 2-.epsilon.-caprolactam, N-methyl-2-caprolactam, 2-piperidone or N-(4-hydroxybenzyl)pyrrolidone.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: December 27, 1994
    Assignee: MicroProbe Corporation
    Inventors: Jeffrey Van Ness, Nicolaas M. J. Vermeulen
  • Patent number: 5362884
    Abstract: Maleimidic derivatives containing acrylic residues having the general formula (I): ##STR1## wherein R is equal to H, CH.sub.3 ; A represents a cycloalkyl radical containing from 5 to 10 carbon atoms or an aryl radical containing from 6 to 12 carbon atoms and with the acryloxy residue --[--OCOC(R).dbd.CH.sub.2 ] in an ortho, meta or para position. The compounds are useful as thermostabilizing agents in structural adhesives with an acrylic base.
    Type: Grant
    Filed: October 27, 1992
    Date of Patent: November 8, 1994
    Assignee: Ministero Dell'Universita' E Della Ricerca Scientifica E Tecnologica
    Inventors: Vittorio Di Ruocco, Liliana Gila, Fabio Garbassi
  • Patent number: 5360913
    Abstract: Salicylic acid derivatives of the formula I ##STR1## (R.sup.1 is succinimidoxy; unsubstituted or substituted hetaryl; OR.sup.5 where R.sup.5 is substituted or unsubstituted cycloalkyl, alkyl, alkenyl, alkynyl, phenyl or substituted methyleneamino; OR.sup.8 where R.sup.8 is hydrogen, alkali metal or alkaline earth metal cation, ammonium or organic ammonium;R.sup.2 and R.sup.3 are each C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.2 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.2 -haloalkoxy and/or C.sub.1 -C.sub.4 -alkylthio;R.sup.4 is ethynyl or unsubstituted or substituted vinyl;X is oxygen or sulfur;Z is nitrogen or methine)are used as herbicides and bioregulators.
    Type: Grant
    Filed: May 24, 1993
    Date of Patent: November 1, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Joachim Rheinheimer, Karl Eicken, Uwe J. Vogelbacher, Karl-Otto Westphalen, Matthias Gerber, Helmut Walter
  • Patent number: 5360914
    Abstract: Provided are novel superoxide dismutase derivatives represented by the following general formula (I) ##STR1## wherein [SOD] is a superoxide dismutase residue derived by removal of two mercapto groups, and W is a divalent long chain hydrocarbon residue which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of -N(R)- (R being a lower alkyl group). The SOD derivatives retain most of the enzymatic activities of unmodified SOD and have much longer plasma half-life than unmodified SOD. They are effective for treating various diseases caused by active oxygen species.Also provided are chemical modifiers to prepare the above SOD derivatives.
    Type: Grant
    Filed: May 11, 1993
    Date of Patent: November 1, 1994
    Assignees: Kuraray Co., Ltd., Masayasu Inoue
    Inventors: Masayasu Inoue, Iwao Ebashi, Tetsuo Takigawa
  • Patent number: 5358651
    Abstract: Succinimide derivatives represented by the formula: ##STR1## wherein X is selected from the group consisting of M, ##STR2## wherein R is a hydrocarbon-based group containing from about 8 up to about 35 carbon atoms, R.sub.1 and R.sub.2 are each independently hydrogen or an alkyl group containing up to 8 carbon atoms; R.sub.4 is a hydrocarbon-based group containing up to about 28 carbon atoms; R.sub.4 and R.sub.5 are each independently hydrogen or a hydrocarbon-based group containing up to about 25 carbon atoms; and M is a metal cation.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: October 25, 1994
    Assignee: The Lubrizol Corporation
    Inventor: Reed H. Walsh
  • Patent number: 5359085
    Abstract: A fulgimide derivative of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are independently alkyl cycloalkyl aryl etc.; R.sup.4 is thienyl, indolyl, furyl, etc.; X is a divalent organic residue; and R is amino, OH, etc., or a vinyl group, has a photochromic action and can be used for producing photochromic polymers and copolymers.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: October 25, 1994
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Osamu Iwamoto, Taizo Hara, Haruhiko Sugiyama
  • Patent number: 5359090
    Abstract: There is provided a safe and effective means of introducing an alkoxymethyl group onto the ring Nitrogen atom of a wide variety of pyrrole compounds via the reaction of the appropriate pyrrole precursor sequentially with dialkoxymethane, Vilsmeier reagent and a tertiary amine. The product 1-(alkoxymethyl)pyrroles are useful as insecticidal, acaricidal, nematocidal and molluscicidal agents.
    Type: Grant
    Filed: December 29, 1993
    Date of Patent: October 25, 1994
    Assignee: American Cyanamid Company
    Inventors: Robert F. Doehner, Jerry M. Barton
  • Patent number: 5329028
    Abstract: The invention is from the field of heterobifunctional cross-linking reagents. More particularly, the invention concerns cross-linking reagents which combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, thereby allowing coupling of aldehydes to free thiols.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: July 12, 1994
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Steven M. Chamow, Timothy P. Kogan
  • Patent number: 5326488
    Abstract: Disclosed is a substance useful as a detergent-dispersant which has excellent stability at high temperatures and has an oxidation stability, a detergent-dispersant containing the same, a process of producing it, and fuel oil and lubricating oil composition comprising it.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: July 5, 1994
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Tomiyasu Minokami, Hiroaki Koshima, Hirotaka Yamasaki, Masahisa Gotoh
  • Patent number: 5324709
    Abstract: A tetrahydrofuran derivative represented by the following general formula [I]: ##STR1## wherein A represents direct bonding or a group represented by --B--CHR.sup.1 --(wherein B represents oxygen atom, sulfur atom or imino group; R.sup.1 represents hydrogen atom or an alkyl group); R represents hydrogen atom, halogen atom, hydroxyl group, an alkoxy group, benzyloxy group, an alkylsulfonyloxy group or a group represented by --O--COR.sup.2 (wherein R.sup.2 represents an alkyl group, a haloalkyl group, an alkenyl group, a cycloalkyl group, phenyl group, benzyl group, an alkoxy group, an alkylamino group or a dialkylamino group; X represents halogen atom; Y represents hydrogen atom or halogen atom) and the herbicide containing the same as the effective ingredient. The compounds of the present invention have exceedingly high herbicidal activity, and furthermore, the compounds are superior to the known similar compounds in terms of safety on crops. Thus, the compounds are useful as herbicides.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: June 28, 1994
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Natsume Bunji, Kyomura Nobuo, Suzuki Seiichi, Takahashi Yoji, Jikihara Tetsuo
  • Patent number: 5312929
    Abstract: A herbicidal 2-oxo-3-pyrroline derivative having the formula: ##STR1## wherein X is a hydrogen atom or a halogen atom, Z is an oxygen atom or a group of the formula .dbd.N--OR.sup.1 (wherein R.sup.1 is a hydrogen atom, an alkyl group, a benzyl group or a phenyl group which is substituted by halogen atoms); and R is a hydrogen atom, an alkyl group, a benzyl group, a chloro-substituted benzyl group, a benzylidene methyl group, a group of the formula ##STR2## wherein Y is a hydrogen atom, a halogen atom, an alkyl group, a haloalkyl group or an alkoxy group, and n is an integer of from 1 to 3, or a group of the formula ER.sup.2 wherein E is an oxygen atom, a sulfur atom or a group of the formula >N--R.sup.3, wherein R.sup.3 is a hydrogen atom, an alkyl group or an alkenyl group, and R.sup.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: May 17, 1994
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Nobuyuki Ohba, Toshihiro Nagata, Akira Takeuchi, Shigehiko Tachikawa, Yasunori Ogawa
  • Patent number: 5306827
    Abstract: Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole compounds which are effective for the control of insects and acarids are described. A method for the insecticidal and acaricidal use of said compounds and methods for the preparation of said compounds are presented.
    Type: Grant
    Filed: December 4, 1991
    Date of Patent: April 26, 1994
    Assignee: American Cyanamid Company
    Inventors: Keith D. Barnes, Victor M. Kamhi, Robert E. Diehl
  • Patent number: 5296607
    Abstract: In chemical structure of a fulgide type photochromic compound having the following general formula; ##STR1## introduction of electron donative groups into its heteroaromatic structure is effective in improving the long wave length sensitivity without any lowering in its thermal stability. Thanks to such combined functional properties, the products are advantageously used for optical recording media, copying media, printing media, optical filters and display materials.
    Type: Grant
    Filed: June 23, 1992
    Date of Patent: March 22, 1994
    Assignee: Yamaha Corporation
    Inventors: Akihiko Tomoda, Hisao Suzuki, Akira Kaneko, Hideki Tsuboi
  • Patent number: 5292873
    Abstract: A sequence directed reagent is constructed by conjugating a methyl naphthoquinone derivative to a hexamethylamino linker attached to the 5' terminus of an oligonucleotide. Annealing this modified fragment of DNA to its complementary sequence allows for target modification subsequent to photochemical activation. The product of this reaction is a covalent crosslink between the reagent and target strands resulting from an alkylation of DNA by the photoexcited quinone. The modified sequence is not labile to acid, base or reductants, and blocks the exonuclease activity of the Klenow fragment of DNA polymerase I. In another embodiment, a highly reactive moiety, such as Br is attached to the methyl group of the naphthoquinone derivative. This reagent is similarly linked to an oligonucleotide probe. Activation of this probe linked alkylating agent is by a reductive signal which may either naturally occur within the cell, such as an enzyme, or introduced into the media containing the target molecule.
    Type: Grant
    Filed: November 29, 1989
    Date of Patent: March 8, 1994
    Assignee: The Research Foundation of State University of New York
    Inventors: Steven E. Rokita, Moneesh Chatterjee
  • Patent number: 5290937
    Abstract: Novel compounds, useful as radiolabeling reagents, including an alkoxy group on the phenyl ring and having the formula ##STR1## wherein X is a radionuclide are disclosed. The invention further includes novel radiohalogenated proteins as well as processes for preparing such reagents and radiohalogenated proteins.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: March 1, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Frank P. Tomasella
  • Patent number: 5286875
    Abstract: A process for preparing a 5-hydroxyethylpyrrolidone of the general formula I ##STR1## where R.sup.1 is hydrogen, C.sub.1 - to C.sub.12 -alkyl, C.sub.3 - to C.sub.8 -cycloalkyl, aryl or C.sub.7 - to C.sub.12 -aralkyl, by reactinga) a caprolactone of the general formula II ##STR2## or b) a butyrolactone of the general formula III ##STR3## where R.sup.2 is C.sub.1 to C.sub.12 -alkyl, ##STR4## R.sup.3 has the meaning of R.sup.2 and is additionally hydrogen and R.sup.4 is C.sub.1 - to C.sub.8 -alkyl or phenyl,with ammonia or a primary amine of the general formula IVR.sup.1 --NH.sub.2 (IV)where R.sup.1 has the abovementioned meanings, at from 150.degree. to 450.degree. C. and at from 10 to 350 bar, and the preparation of the caprolactones II and the butyrolactones III from the cyclohexanones V.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: February 15, 1994
    Assignee: BASF Aktiengesellschaft
    Inventor: Rolf Fischer
  • Patent number: 5281698
    Abstract: The present invention is a process for preparing an activated ester of polyethylene glycol or a polyoxyethylated polyol. After the activated ester is prepared, it can be reacted with a protein to form a polymer/protein conjugate. Conjugation with a polymer can reduce the protein's immunogenicity, increase its solubility, and increase its circulating in vivo half-life. Preferred proteins are IL-2, CSFs, and interferons.
    Type: Grant
    Filed: July 23, 1991
    Date of Patent: January 25, 1994
    Assignee: Cetus Oncology Corporation
    Inventor: Danute E. Nitecki
  • Patent number: 5273668
    Abstract: The present invention is directed to an oil-soluble lubricating oil additive comprising at least one adduct of (A) a polyolefin of 700 to 5,000 number average molecular weight substituted nitrogen- or ester-containing ashless dispersant and (B) a bis-keto/thioketo compound.
    Type: Grant
    Filed: January 25, 1993
    Date of Patent: December 28, 1993
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Jacob Emert, Antonio Gutierrez, Robert D. Lundberg
  • Patent number: 5256324
    Abstract: Preconditioned automatic transmission fluids are made by using a preblend formed by heating an alkenyl succinimide or succinamide dispersant with a phosphorus ester and water to partially hydrolyze the ester and then mixing the preblend and other additives with a base oil.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: October 26, 1993
    Assignee: Ethyl Petroleum Additives, Inc.
    Inventor: Andrew G. Papay
  • Patent number: 5256692
    Abstract: Novel sulfur-containing compounds which inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, having a sulfur-containing side-chain bonded to a hydrophobic anchor group through an acetylenic or ethylenic linkage. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atheroschlerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.
    Type: Grant
    Filed: January 7, 1992
    Date of Patent: October 26, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Jelka Pluscec
  • Patent number: 5234894
    Abstract: A cyanoketone derivative of the following formula (1) ##STR1## wherein A.sub.1 is a substituted or unsubstituted phenyl or naphthyl group or a substituted or unsubstituted heterocyclic group;each of X.sub.1, X.sub.2 and X.sub.3 is independently an oxygen or sulfur atom;each of B.sub.1, B.sub.2 and B.sub.3 is independently a hydrogen atom or C.sub.1 -C.sub.6 -alkyl group;each of Y.sub.1, Y.sub.2, Y.sub.3 and Y.sub.4 is independently a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.6 -alkyl group; andA.sub.2 is a substituted or unsubstituted group selected from the group consisting of a C.sub.1 -C.sub.6 -alkyl group, a C.sub.2 -C.sub.6 -alkenyl group, a C.sub.2 -C.sub.6 -alkynyl group, a C.sub.1 -C.sub.4 -alkoxy group, a C.sub.1 -C.sub.4 -alkylthio group, a C.sub.1 -C.sub.6 -alkoxycarbonyl group, an unsubstituted benzoyl group, a halogen-substituted benzoyl group, a cyano group or a group as defined in A.sub.1 ;provided that when B.sub.1 is a hydrogen atom and B.sub.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: August 10, 1993
    Assignee: Tokuyama Soda Kabushiki Kaisha
    Inventors: Masahiko Ishizaki, Seiji Nagata, Tadashi Kobutani
  • Patent number: 5234476
    Abstract: Polynitrogen compound having two terminal cycles of the imide type, its preparation by conventional organic chemistry methods and its use as an additive for engine fuel. This compound complies with the general formula (I): ##STR1## in which R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as set forth in the specification.
    Type: Grant
    Filed: July 30, 1992
    Date of Patent: August 10, 1993
    Assignees: Institut Francais du Petrole, Elf France
    Inventors: Jacques Garapon, Roger Bregent, Remi Touet, Philippe Mulard, Pierre Schmelzle
  • Patent number: 5229020
    Abstract: The present invention is directed to branched amido-amine dispersant additives useful in oleaginous compositions formed by (a) reacting a first nitrogen-containing compound (e.g., ammonia or an organic amine) with an alpha, beta-unsaturated compound of the formula: ##STR1## wherein W.sup.1 is sulfur or oxygen, Y is --OR.sup.4, --SR.sup.4, or --NR.sup.4 (R.sup.5), and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are hydrogen or substituted or unsubstituted hydrocarbyl, to form a first adduct containing unreacted --C(W.sup.1)--Y groups; (b) reacting the first adduct with a polyamine (e.g., a polyalkylene polyamine) to form a second adduct containing unreacted --NH-- groups (preferably primary amine groups) and comprising a branched amido-amine oligomer; and (c) reacting the second adduct with a long chain hydrocarbyl substituted mono- or dicarboyxlic acid material comprising a polyolefin of 300 to 10,000 number average molecular weight substituted with at least 0.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: July 20, 1993
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Antonio Gutierrez, Robert D. Lundberg
  • Patent number: 5221491
    Abstract: The invention relates to a two-cycle oil additive, compositions and concentrates containing said two-cycle oil additive and methods of preparing and using the two-cycle oil additive which comprises the reaction product of (A) at least one high molecular weight acylating agent (B) at least one polyalkylenpolyamine and (C) at least one monocarboxylic second acylating agent, wherein the molar ratio of the carboxylic acid acylating agent to the high molecular weight acylating agent is at least 3:1 and wherein the tertiary amine to total amine ratio of the reaction product is at least 0.7:1. The two-cycle oil additive of the invention are dispersant additives which will improve engine cleanliness and which will substantially avoid the formation of insoluble gel agglomerants at low temperatures which can adversely affect engine performance.
    Type: Grant
    Filed: August 9, 1991
    Date of Patent: June 22, 1993
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Renee M. Roper, George M. Tiffany, III, William H. Stover, William R. Thompson
  • Patent number: 5204366
    Abstract: 2,5-Dioxo-3-pyrroline-1-acetanilide compounds which are effective for the control or prevention of phytopathogenic fungi are described. A method for the fungicidal use of said compounds, fungicidal compositions containing said compounds and a method for the preparation of said compounds are also presented.
    Type: Grant
    Filed: June 10, 1991
    Date of Patent: April 20, 1993
    Assignee: American Cyanamid Company
    Inventors: Jerome M. Lavanish, Bomi Patel
  • Patent number: 5200529
    Abstract: A new monomer is used to prepare homo or copolymers containing blocked imide groups which are characterized by deblocking in two stages, first when acid catalyzed and thereafter in aqueous alkaline solutions. Such polymers are, therefore, especially useful in formulating positive photoresist compositions. The polymers are combined with a latent photoacid, which when exposed to actinic radiation removes the acid sensitive blocking moiety, preferably an acetal or ketal group, leaving a methylol group or substituted methylol group remaining attached to the nitrogen atom, which groups are subsequently removed by exposure to aqueous alkaline developing solutions, leaving only imide groups. ##STR1## The new monomer is a derivative of maleimide in which the imide hydrogen has been replaced with a methylol group, which is subsequently reacted to form an acetal or ketal. Preferred monomers include N-(2,4-dioxa-3,3-dimethylpentyl)-2H,5H-2,5-dioxopyrrole and related compounds.
    Type: Grant
    Filed: October 25, 1991
    Date of Patent: April 6, 1993
    Assignee: Hoechst Celanese Corporation
    Inventors: Christopher E. Osuch, Michael J. McFarland
  • Patent number: 5198526
    Abstract: Linear or multidimensional, crosslinking, solvent resistant oxazole, thiazole, or imidazole (i.e., heterocycle) oligomers and blends of the crosslinking oligomers and noncrosslinking comparable polymers are described. The oligomers are prepared by reacting tetraamines, diaminodiols, or diaminothiols (i.e. four-functional compounds) with poly-carboxylic acid halides, and crosslinking phenylimide end cap monomers in a suitable solvent under an inert atmosphere.
    Type: Grant
    Filed: June 26, 1992
    Date of Patent: March 30, 1993
    Assignee: The Boeing Company
    Inventors: Hyman R. Lubowitz, Clyde H. Sheppard
  • Patent number: 5198133
    Abstract: Preconditioned automatic transmission fluids are made by using a preblend formed by heating an alkenyl succinimide or succinamide dispersant with a phosphorus ester and water to partially hydrolyze the ester and then mixing the preblend and other additives with a base oil.
    Type: Grant
    Filed: June 22, 1992
    Date of Patent: March 30, 1993
    Assignee: Ethyl Petroleum Additives, Inc.
    Inventor: Andrew G. Papay
  • Patent number: 5180418
    Abstract: Cycloalkanecarboxylic acid derivatives of formula I ##STR1## wherein W is ##STR2## and A is CO--R.sub.3 or CN; R.sub.1 is hydrogen or fluorine; R.sub.2 is halogen or cyano; R.sub.3 is chlorine, X--R.sub.5, amino, C.sub.1 -C.sub.4 alkylamino, d-C.sub.1 -C.sub.4 alkylamino, C.sub.2 -C.sub.4 haloalkylamino, di-C.sub.2 -C.sub.4 haloalkylamino, C.sub.1 -C.sub.4 hydroxyalkylamino, di-C.sub.1 -C.sub.4 hydroxyalkylamino, C.sub.3 -C.sub.4 alkenylamino, diallylamino, --N-pyrrolidino, --N-piperidino, --N-morpholino, --N-thiomorpholino, --N-piperidazino, the group --O--N.dbd.C--(R.sub.9)R.sub.10 or the group --N--R.sub.6 (OR.sub.6); each of R.sub.4 and R.sub.14, independently of the other, is hydrogen, fluorine, chlorine, bromine, C.sub.1 -C.sub.4 alkyl or trifluoromethyl; R.sub.5 is hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.10 alkylthio-C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 alkylamino-C.sub.1 -C.sub.4 alkyl, cyano-C.sub.1 -C.sub.
    Type: Grant
    Filed: July 19, 1991
    Date of Patent: January 19, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Georg Pissiotas, Hans Moser, Hans-Georg Brunner, Eginhard Steiner
  • Patent number: 5169409
    Abstract: Reaction products which provide antioxidant properties to lubricants and fuels while serving as effective dispersants and detergents in these mediums. These products, of the reaction of a hydroxyalkylene substituted polyamines and substituted succinic anhydrides, contain mixtures of esters, amides and imides. Furthermore, preferred embodiments of the reaction products have pendent alcohol groups which provide extra dispersancy and detergency over traditional dispersants which typically do not have alcohol groups.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: December 8, 1992
    Assignee: Mobil Oil Corp.
    Inventors: David A. Blain, Angeline B. Cardis
  • Patent number: 5162571
    Abstract: Novel phenol derivatives of the general formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X, Y and n are as defined in the specification, which have therapeutic and prophylactic activities against cerebral, cardiac, renal and pulmonary circulatory system diseases, respiratory diseases, allergy, anaphylactic shock, endotoxin shock, inflammation and the like as well as inhibiting activities against vascularization by oncocytes.
    Type: Grant
    Filed: June 8, 1988
    Date of Patent: November 10, 1992
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Mitsuru Shiraishi, Kohei Mishikawa
  • Patent number: 5124444
    Abstract: This invention relates to novel methods for the extraction of nucleic acid. In particular methods are described for isolating nucleic acid from a sample containing a complex biological mixture of nucleic acid and non-nucleic acids wherein the sample is combined with an extraction solution comprising a lactam and then the nucleic acid material is isolated from the resulting combined solution. The resulting combined solution is mixed and becomes biphasic and the nucleic acid material is isolated from the aqueous phase by precipitation with ethanol. The lactam is preferably about 5 to about 70% of the extraction solution and is most preferably 2-pyrrolidone, N-ethyl-2-pyrrolidone, N-cyclohexyl-2-pyrrolidone, N-dodecyl-2-pyrrolidone, N-methyl-2-pyrrolidone, N-hydroxyethyl-2-pyrrolidone, N-methyl-2-piperidone, 2-.epsilon.-caprolactam, N-methyl-2-caprolactam, 2-piperidone or N-(4-hydroxybenzyl)pyrrolidone. Methods for selectively isolating DNA, ribosomal RNA and plasmid DNA are also disclosed.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: June 23, 1992
    Assignee: MicroProbe Corporation
    Inventors: Jeffrey Van Ness, Nicolaas Vermuelen, B. Melina Cimler
  • Patent number: 5112507
    Abstract: Novel copolymers of unsaturated acidic reactants and high molecular weight olefins wherein at least 20 percent of the total high molecular weight olefin comprises the alkylvinylidene isomer are useful as dispersants in lubricating oils and fuels and also may be used to prepare polysuccinimides and other post-treated additives useful in lubricating oils and fuels.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: May 12, 1992
    Assignee: Chevron Research and Technology Company
    Inventor: James J. Harrison
  • Patent number: 5106730
    Abstract: This invention relates to novel methods for the release of nucleic acids from cells in complex biological samples or specimens to prepare and make available the nucleic acid material present for a hybridization assay or for extraction. Novel methods for hybridization of nucleic acids are also presented. In particular methods are described for isolating nucleic acid from a sample containing a complex biological mixture of nucleic acid and non-nucleic acids wherein the sample is combined with a hybridization medium comprising a lactam which promotes and enables nucleic acid pairing when complementary nucleic acid is introduced. The lactam is preferably about 5 to about 70% of the hybridization medium and is most preferably 2-pyrrolidone, N-ethyl-2-pyrrolidone, N-cyclohexyl-2-pyrrolidone, N-dodecyl-2-pyrrolidone, N-methyl-2-pyrrolidone, N-hydroxyethyl-2-pyrrolidone, N-methyl-2-piperidone, 2-.epsilon.-caprolactam, N-methyl-2-caprolactam, 2-piperidone or N-(4-hydroxybenzyl)pyrrolidone.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: April 21, 1992
    Assignee: MicroProbe Corporation
    Inventors: Jeffrey Van Ness, Nicolaas M. J. Vermeulen
  • Patent number: 5102570
    Abstract: A lubricating oil composition having improved dispersancy and antioxidancy. The dispersant being prepared by coupling mono- and/or bis-alkenyl succinimides with an aldehyde and hydroxyaromatic amine. The resulting coupled succinimide is then acylated with an acylating agent to form a Mannich hydroxyaromatic amine coupled acylated mono and/or bis-alkenyl succinimide.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: April 7, 1992
    Assignee: Texaco Inc.
    Inventors: Cyril A. Migdal, Richard A. Abramshe, Theodore E. Nalesnik
  • Patent number: 5101059
    Abstract: This invention relates to compounds of the formula a compound of the formula ##STR1## wherein X is O, CR.sub.7 R.sub.8, S or NR.sub.9 wherein R.sub.7 and R.sub.8 are independently hydrogen, or lower alkyl, and R.sub.9 is lower alkyl;n is 0 or 1;R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, monoorganosilyl, diorganosilyl, triorganosilyl, halogen, aryl, or nitro;R.sub.3 is hydrogen, lower alkyl, monoorganosilyl, diorganosilyl, triorganosilyl, halogen, 9-fluorenylalkyl, cycloalkyl, aryl or aralkyl;R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl, or aryl or one of R.sub.4 and R.sub.5 is 9-fluorenyl;R.sub.6 is H or COZ wherein Z is an amino acid, a peptide residue or a leaving group; andwith the provisos that when n is 0 and R.sub.3 is hydrogen, R.sub.1 and R.sub.2 are not hydrogen, halogen or nitro; that when n is 0 and R.sub.3 is lower alkyl, R.sub.1 and R.sub.2 are not hydrogen; and that when X is O or CR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are H, that R.sub.1, R.sub.2, R.sub.
    Type: Grant
    Filed: December 5, 1989
    Date of Patent: March 31, 1992
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, An-Chuu Wu
  • Patent number: 5082905
    Abstract: Linear or multidimensional, crosslinking, solvent resistant oxazole, thiazole, or imidazole (i.e., heterocycle) oligomers and blends of the crosslinking oligomers and noncrosslinking comparable polymers are described. The oligomers are prepared by reacting tetraamines, diaminodiols, or diaminothiols (i.e. four-functional compounds) with poly-carboxylic acid halides, and crosslinking phenylimide end cap monomers in a suitable solvent under an inert atmosphere.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: January 21, 1992
    Assignee: The Boeing Company
    Inventors: Hyman R. Lubowitz, Clyde H. Sheppard
  • Patent number: 5079331
    Abstract: Heat-resistant epoxy resin composition obtained by incorporation of 2-(4-hydroxyphenyl)-2-(4-maleimidophenyl)propane in a resin composition consisting esssentially of epoxy resin and an epoxy hardener is disclosed.
    Type: Grant
    Filed: May 23, 1990
    Date of Patent: January 7, 1992
    Assignee: Mitsui Toatsu Chemical, Inc.
    Inventors: Mikio Kitahara, Koichi Machida, Takayuki Kubo, Motoyuki Torikai, Koutarou Asahina, Yoshimitsu Tanabe, Keizaburo Yamaguchi, Akihiro Yamaguchi
  • Patent number: 5075335
    Abstract: A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m --, m being an integer of 2 or 3, ##STR3## or a group of the formula:--ORin which R is a hydrogen atom or a lower alkyl group, and n represents an integer of 1 to 5.
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: December 24, 1991
    Assignee: Eisai Co., Ltd.
    Inventors: Shigeru Souda, Naoyuki Shimomura, Norihiro Ueda, Shuhei Miyazawa, Takashi Yamanaka, Kaname Miyamoto, Ieharu Hishinuma, Junichi Nagakawa, Naoko Nagaoka, Hidetoshi Kawashima, Tsutomu Kawata, Junsaku Nagaoka, Tsuneo Wakabayashi
  • Patent number: 5071941
    Abstract: The solvent resistance of polyethersulfone oligomers is enhanced by using difunctional imidophenol end-cap monomers to provide improved crosslinking. The imidophenol monomers include two unsaturated functionalities capable of cross-linking upon thermal or chemical activation. Blends, pregregs, and composites using the novel end caps are described for linear or multidimensional polyethersulfone oligomers.
    Type: Grant
    Filed: March 6, 1989
    Date of Patent: December 10, 1991
    Assignee: The Boeing Company
    Inventors: Hyman R. Lubowitz, Clyde H. Sheppard
  • Patent number: 5061291
    Abstract: A motor fuel composition which inhibits engine ORI and intake valve deposit formation comprises a mixture of hydrocarbons boiling in the range of 90.degree.-450.degree. F. and the reaction product of a hydrocarbyl-substituted dibasic acid anhydride and a polyoxyalkylene diamine; it may optionally additionally comprise a polymeric component which is a polyolefin polymer, copolymer, or the corresponding aminated or hydrogenated polymer or copolymer, or mixtures thereof, of a C.sub.2 -C.sub.10 hydrocarbon. Motor fuel compositions of the instant invention show improved ORI control in comparison with typical commercial fuel compositions. The instant invention is advantageous in that it may be produced and stored as a precipitation-resistant concentrate composition.
    Type: Grant
    Filed: December 28, 1989
    Date of Patent: October 29, 1991
    Assignee: Texaco Inc.
    Inventor: Rodney L. Sung
  • Patent number: 5039696
    Abstract: A maleimide derivative useful as an active agent for a fungicide for agriculture and horticulture, having the formula (I): ##STR1## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an aralkyloxy group or a trifluoromethyl group,Z represents a chlorine atom or bromine atom,and R represents a straight or branched alkyl group having 1 to 15 carbon atoms, an alkenyl group having 2 to 5 carbon atoms, an alkynyl group having 2 to 5 carbon atoms, an alkoxyalkyl group having 2 to 5 carbon atoms, an oxoalkyl group having 3 to 6 carbon atoms or a phenyl group or a phenyl alkyl group which may be substituted.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: August 13, 1991
    Assignee: Suntory Limited
    Inventors: Shinjiro Niwata, Harukazu Fukami, Masaki Hashimoto, Norio Ohtsuka, Fumio Fujita
  • Patent number: 5021487
    Abstract: The invention comprises a curable acrylic ester formulation which contains a maleimide thermal additive which is essentially miscible in conventional acrylic monomers. The formulation comprises a substantially solvent free adhesive formulation comprising:a) an acrylic functional maleimide compound of the formula: ##STR1## where the R.sub.1 groups are independently H or C.sub.1 -C.sub.3 alkyl, R.sup.2 is lower alkylene and R.sup.3 is defined as for R.sup.1 ;b) at least one acrylate or methacrylate monomer or prepolymer compound other than a compound as defined in a); and,c) an effective amount of an anaerobic or thermal free radical initiator.
    Type: Grant
    Filed: May 27, 1988
    Date of Patent: June 4, 1991
    Assignee: Loctite Corporation
    Inventor: Philip Klemarczyk
  • Patent number: 5011905
    Abstract: Polyimide oligomers include (1) linear, monofunctional crosslinking oligomers prepared by condensing a monoanhydride end cap with a diamine that includes alternating ether and "sulfone" (--SO.sub.2 --, --S--, --CO--, --(CF.sub.3).sub.2 C--, or --(CH.sub.3).sub.2 C--) linkages connecting alternating aromatic radicals and with a dianhydride (or dianhydride mixture), particularly the unsaturated, aliphatic dianhydride commonly known as MCTC; (2) linear, mono- or difunctional crosslinking oligomers prepared by condensing an amine end cap with a diamine and a dianhydride; and (3) multidimensional, crosslinking oligomers having an aromatic hub and at least three radiating arms connected to the hub, each arm including a crosslinking end cap at its distal end and at least one imide linkage.Blends, prepregs, and composites can be prepared from the oligomers.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: April 30, 1991
    Assignee: The Boeing Company
    Inventors: Hyman R. Lubowitz, Clyde H. Sheppard
  • Patent number: 4996330
    Abstract: Chiral substituted tartarimides, a process for their preparation and their use as doping agents in liquid-crystal mixtures.The new chiral N-substituted tartarimides which are esterified on both of the OH groups (pyrrolidinediones) are characterized by the general formula (I) ##STR1## in which the symbols have the following meaning: R.sup.2 denotes linear or branched (C.sub.1 -C.sub.16)-alkyl, it being possible for one or two non-adjacent CH.sub.2 groups to be replaced by O or S, or, if n1=1, also denotes F, Cl, Br or CN,A.sup.1 and A.sup.2 independently of one another denote 1,4-phenylene, diazine-2,5-diyl, diazine-3,6-diyl, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 1,3-dithiane-2,5-diyl or 1,4-bicyclo(2,2,2)octylene, it being also possible for these groups to be at least monosubstituted by F, Cl, Br, CN and/or (C.sub.1 -C.sub.12)-alkyl (if appropriate one or two non-adjacent CH.sub.2 groups are replaced by O atoms),denotes CO--O, O--CO, CH.sub.2 --CH.sub.2, OCH.sub.2, CH.sub.2 O, CH.dbd.N, N.dbd.CH or N.dbd.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: February 26, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunter Scherowsky, Peter Schreiber
  • Patent number: 4985561
    Abstract: A process is described for obtaining sulfophenyl quaternary ammonium or phosphonium substituted carbonic acid esters. These esters are prepared through sulfonation with sulfur trioxide of aromatic chloroformates followed by reaction of the sulfonated aromatic chloroformate with quaternary ammonium or phosphonium substituted alcohols. The resultant sulfophenyl esters are useful as bleach precursors in combination with peroxygen compounds such as sodium perborate or percarbonate.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: January 15, 1991
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventors: Stephen A. Madison, Leonora M. Ilardi, Hans Cerfontain
  • Patent number: 4981979
    Abstract: Method for producing an immunoconjugate comprising the steps of reacting a toxin or protein with a heterobifunctional reagent having the following general formula: ##STR1## where R.sub.1 is: ##STR2## where n=1 to 10; and where R.sub.2 is selected from the group consisting of o- and p-nitrophenyl, 2-chloro-4-nitrophenyl, cyanomethyl, 2-mercaptopyridyl, hydroxybenztriazole, N-hydroxysuccinimide, trichlorophenyl, tetrafluorophenyl, 2-fluorophenyl, 4-fluoropheyl, 2,4-difluorophenyl, o-nitro-p-sulfophenyl, N-hydroxyphthalimide, N,N-diethylamino, N-hydroxypyrrolidone, tetrafluorothiophenyl, and 2,3,5,6-tetrafluorophenyl, under reactive conditions, thereby forming a derivatized toxin or protein.
    Type: Grant
    Filed: September 10, 1987
    Date of Patent: January 1, 1991
    Assignee: NeoRx Corporation
    Inventor: Gowsala Sivam