Polycyclo Ring System Having The Lactone Ring As One Of The Cyclos Patents (Class 549/268)
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Patent number: 6919464Abstract: Macrolide compounds produced by synthetic modification of factors produced by NRRL 30141 have insecticidal and acaricidal activity and are useful intermediates for preparing additional insecticidal and acaricidal compoundsType: GrantFiled: March 21, 2002Date of Patent: July 19, 2005Assignee: Dow AgroSciences LLCInventors: Gary D. Crouse, Donald R. Hahn, Paul R. Graupner, Jeffrey R. Gilbert, Paul Lewer, Jesse L. Balcer
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Patent number: 6900339Abstract: Methods for obtaining bryostatins from the marine bryozoans of the Bugula neritina species complex are provided wherein the methods involve the extraction and purification of bryostatins from the larvae of Bugula neritina organisms. Further, the present invention relates to a novel bryostatin composition that can be extracted from Bugula neritina.Type: GrantFiled: April 30, 2003Date of Patent: May 31, 2005Assignee: The University of North Carolina at Chapel HillInventors: Niels Lindquist, Nicole Lopanik
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Publication number: 20040242858Abstract: The present invention relates to methods for producing novel spinosyn derivatives which are substituted with a 1-hydroxy-ethyl radical in the C-21 position and to novel spinosyn derivatives of this type per se and to their use for producing novel spinosyns.Type: ApplicationFiled: July 9, 2004Publication date: December 2, 2004Inventors: Peter Jeschke, Gunther Eberz, Rita Frode, Volker Mohrle, Robert Velten
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Patent number: 6818667Abstract: The present invention relates to novel compounds of the formula I in which R(1), R(2), R(3) and R(4) are, independently of each other, hydrogen or an alkyl radical. The compounds of the formula I are inhibitors of KDR kinase and, due to their antiangiogenic effect, are suitable for preventing and/or treating malignant diseases. The compounds of the formula I can be obtained by fermenting the microorganism Eurotium echinulatum Delacroix (DSM 13872) or by chemically derivatizing the compounds which are obtained after fermenting said microorganism. The invention consequently also relates to a process for preparing the compounds of the formula I, to the use of the compounds of the formula I for preparing a pharmaceutical for treating malignant diseases and diseases which can be treated by inhibiting KDR kinase, and also to pharmaceutical preparations which have a content of at least one compound of the formula I.Type: GrantFiled: June 26, 2002Date of Patent: November 16, 2004Assignee: Aventis Pharma Deutschland GmbHInventors: Claudia Eder, Herbert Kogler, Luigi Toti
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Patent number: 6815463Abstract: Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation.Type: GrantFiled: February 10, 2003Date of Patent: November 9, 2004Assignee: Kosan Biosciences, Inc.Inventors: Gary Ashley, Brian Metcalf
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Patent number: 6808724Abstract: The present invention relates to a novel compound isolated from Artemisia Sylvatica, expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to a novel compound isolated from Artemisia Sylvatica, a method of isolation, and its use in inhibiting farnesyl transferase activity, which is essential for activating Ras oncogene, and repressing cancer cell growth.Type: GrantFiled: January 28, 2003Date of Patent: October 26, 2004Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong-Choi Han, Jong-Han Kim, Hyun-Mi Kang, Sun Bok Jeon
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Publication number: 20040147766Abstract: The present invention relates to intermediates for preparing spinosyns, to a variety of processes for their preparation, and to the use of these intermediates for preparing spinosyn derivatives.Type: ApplicationFiled: March 3, 2004Publication date: July 29, 2004Inventors: Marc Stadler, Anke Mayer-Bartschmid, Stephan Seip, Robert Velten, Peter Jeschke, Karlheinz Weber
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Patent number: 6670389Abstract: Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation.Type: GrantFiled: February 8, 2002Date of Patent: December 30, 2003Assignee: Kosan Biosciences, Inc.Inventors: Gary Ashley, Brian Metcalf
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Patent number: 6670348Abstract: Compounds having an ansamycin anitibiotic, or other moiety which binds to hsp90, coupled to a targeting moiety which binds specifically to a protein, receptor or marker can provide effective targeted delivery of the ansamycin antibiotic leading to the degradation of proteins and death of the targeted cells. These compositions may have different specificity than the ansamycin alone, allowing for a more specific targeting of the therapy, and can be effective in instances where the ansamycin alone has no effect. Thus, these compounds provide an entirely new class of targeted chemotherapy agents with application, depending on the nature of the targeting moiety, to treatment of a variety of different forms of cancer. Such agents can further be used to promote selective degradation of proteins associated with the pathogenesis of others diseases, including antigens associated with autoimmune disorders and pathogenic proteins associated with Alzheimer's disease.Type: GrantFiled: October 20, 1999Date of Patent: December 30, 2003Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Neal Rosen, Samuel Danishefsky, Ouathek Ouerfelli, Scott D. Kuduk, Laura Sepp-Lorenzino
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Publication number: 20030203929Abstract: Laulimalide and epothilone derivatives useful as microtubule stabilizing agents, and in the treatment of cancers are disclosed. Methods of making the compounds and using the compounds as therapeutic agents in treating cancers also are disclosed.Type: ApplicationFiled: March 5, 2003Publication date: October 30, 2003Inventor: Arun K. Ghosh
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Patent number: 6617304Abstract: The invention discloses a method for the production of a macrocyclic lactone represented by a formula (2), which comprises subjecting a hydroxycarboxylic acid ester represented by a formula (1) to intramolecular esterification reaction. In the formulae (1) and (2), m is an integer of from 5 to 10, n is an integer wherein m+n becomes from 11 to 16, X represents —CH2—, —CH═CH—, —O—, —S— or —NH—, and R represents a hydrocarbon group having from (m+n+2) to 40 carbon atoms or a group represented by —(AO)pR1 wherein AO represents an alkyleneoxy group having from 2 to 4 carbon atoms, p is average addition mole number of alkylene oxide and R1 represents a hydrocarbon group having a specified number of carbon atoms so that the total number of carbon atoms of the —(AO)pR1 group becomes from (m+n+2) to 40.Type: GrantFiled: November 7, 2000Date of Patent: September 9, 2003Assignee: Kao CorporationInventors: Takashi Aoki, Shinji Kotachi, Junji Koshino
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Patent number: 6610736Abstract: The invention relates to novel epothilone derivatives of general formula (I), wherein R8 means a halogen atom, especially a fluorine or chlorine atom, and the remaining substituents have the meanings given in the description. The novel compounds are suitable for producing medicaments.Type: GrantFiled: December 7, 2001Date of Patent: August 26, 2003Assignee: Schering AGInventors: Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Michael Schirner
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Publication number: 20030148210Abstract: A polymeric compound for photoresist of the invention includes at least one monomer unit represented by following Formula (I): 1Type: ApplicationFiled: September 19, 2002Publication date: August 7, 2003Inventors: Yoshinori Funaki, Kiyoharu Tsutsumi, Keizo Inoue, Tomoko Adachi
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Publication number: 20030139460Abstract: The invention relates to novel epothilon derivatives which are characterized by an oxygen atom in position 9 of the epothilon skeleton. The novel compounds interact with tubulin, stabilizing formed microtubuli. They can influence cell division in a phase-specific manner and are suitable for use in the treatment of malignant tumors such as ovarian, stomach, colon, adeno, breast, lungs, head and neck carcinoma, malignant melanoma, acute lymphocytic and myelocytic leukaemia. They are also suitable for anti-angiogenesis thereapy and for use in the treatment of chronic inflamatory diseases (psoriasis, arthritis). In order to avoid uncontrolled proliferation of cells on and to improve the compatibility of medical implants, they can be placed on or in polymer materials. The inventive compounds can be used on their own or to obtain additive or synergistic effects in combination with other classes of substances and principles which can be used in tumoral therapy.Type: ApplicationFiled: October 18, 2002Publication date: July 24, 2003Inventors: Wolfgang Schwede, Ulrich Klar, Werner Skuballa, Bernd Buchmann, Jens Hoffmann, Rosemarie Lichtner
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Publication number: 20030125375Abstract: The present invention relates to novel compounds of the formula I 1Type: ApplicationFiled: June 26, 2002Publication date: July 3, 2003Inventors: Claudia Eder, Herbert Kogler, Luigi Toti
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Patent number: 6504035Abstract: The present invention relates to derivatives of 3-deoxy desmycosin of the formula I, wherein, starting from triply protected desmycosin, there are performed an oxidation at C-3 in the first step and then, optionally, a hydrogenation of double bonds and an epoxidation followed by a reductive opening of the oxirane ring. The present invention also relates to derivatives of 3-deoxy-desmycosin of the formula II, wherein in the first step triacetyl desmycosin is hydrogenated and then, via an intermediate mesylate, it is converted to a 2,3-didehydro derivative; or 2,3-didehydro-desmycosin is subjected to epoxidation reactions followed by a reductive opening of the oxirane ring.Type: GrantFiled: January 28, 2002Date of Patent: January 7, 2003Assignee: PLIVA, farmaceutska industrija, dionicko drustvoInventors: Amalija Narandja, Nevenka Lopotar, Marko Djerek, Dra{haeck over (z)}en Pavlović
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Publication number: 20020137789Abstract: Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or imroved recognition domains are disclosed, including methods of preparing and utilizing the same.Type: ApplicationFiled: November 30, 2000Publication date: September 26, 2002Inventors: Paul A. Wender, Blaise Lippa, Cheol-Min Park, Kevin W. Hinkle
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Patent number: 6369099Abstract: A method of modifying or altering the structure of a 1&agr;-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1&agr;-hydroxyl in the axial orientation. This is accomplished by either locking the A-ring chair conformation in a geometry having an axially orientated 1&agr;-hydroxyl, or by the addition of one or more substituents to the A-ring which interact with other substituents in the molecule or on the A-ring to provide a driving force to the A-ring to adopt a chair conformation which presents the 1&agr;-hydroxyl in the axial orientation.Type: GrantFiled: April 20, 2000Date of Patent: April 9, 2002Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Rafal R. Sicinski
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Publication number: 20020022598Abstract: Agents for inducing apoptosis comprising a tetrocarcin derivative represented by the following formula (I) or a salt thereof as an active ingredient (- - - - represents a single bond or a double bond; j and k represent 0 or 1; R1 to R3, R7 to R10 and R14 represent a hydrogen atom, a lower alkyl group and the like; R4, R11, R12, R13 and R15 to R18 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like; R5 and R6 represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a group represented by the following formula (B) (R32 represents a formyl group and the like, R33 to R35 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like); R19 represents a hydroxyl group, a lower alkoxyl group, a lower alkanoyloxy group and the like). The agents are useful as medicaments for preventive and/or therapeutic treatment of diseases resulting from increased expression of Bcl-2 family proteins, for example, cancers, AIDS and the like.Type: ApplicationFiled: February 27, 2001Publication date: February 21, 2002Applicant: KYOWA HAKKO KOGYO CO., LTDInventors: Mitsunobu Hara, Takayuki Nakashima, Yutaka Kanda, Masami Hamano, Shun-ichi Ikeda, Yuko Uosaki, Yoko Takata, Junji Kanazawa
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Publication number: 20010053858Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof which comprise subjecting one or more substituted or unsubstituted penten-1-ols to carbonylation in the presence of a carbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce said one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof. The substituted and unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., epsilon caprolactam. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof as principal product(s) of reaction.Type: ApplicationFiled: December 4, 2000Publication date: December 20, 2001Inventors: Erik Bruce Tjaden, John Robert Briggs, Anil Sakharam Guram, John Michael Maher
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Patent number: 6307065Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof which comprise subjecting one or more substituted or unsubstituted penten-1-ols to carbonylation in the presence of a carbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce said one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof. The substituted and unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., epsilon caprolactam. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof as principal product(s) of reaction.Type: GrantFiled: December 4, 2000Date of Patent: October 23, 2001Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: Erik Bruce Tjaden, John Robert Briggs, Anil Sakharam Guram, John Michael Maher
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Patent number: 6222048Abstract: The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).Type: GrantFiled: June 12, 1997Date of Patent: April 24, 2001Assignee: Merck Frosst Canada & Co.Inventors: Cameron Black, Erich Grimm, Serge Leger, Petpiboon Prasit, Zhaoyin Wang
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Patent number: 6184391Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof which comprise subjecting one or more substituted or unsubstituted penten-1-ols to carbonylation in the presence of a carbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce said one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof. The substituted and unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., epsilon caprolactam. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof as principal product(s) of reaction.Type: GrantFiled: April 15, 1997Date of Patent: February 6, 2001Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: Erik Bruce Tjaden, John Robert Briggs, Anil Sakharam Guram, John Michael Maher
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Patent number: 6100293Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.Type: GrantFiled: October 1, 1998Date of Patent: August 8, 2000Assignee: Merck & Co., Inc.Inventors: Robert K. Baker, Jianming Bao, Frank Kayser, Shouwu Miao, William H. Parsons, Kathleen M. Rupprecht
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Patent number: 6090952Abstract: The invention discloses a process for the preparation of a compound, having molecular formula C.sub.29 H.sub.50 O.sub.6 and isomeric structural formulae (2R, 3S, 22R, 23R) -2, 3, 22, 23 -tetrahydroxy-24- ethyl-.beta.-homo-7-oxa -5.alpha.- cholestan-6- one and (2R, 3S, 22S, 23S) -2, 3, 22-23-tetrahydroxy-24- ethyl-.beta.-homo-7-oxa-5.alpha.-cholestan -6- one in a ratio 69:31, both of which are members of a new class of steroidal phytohormones.Type: GrantFiled: March 30, 1998Date of Patent: July 18, 2000Assignee: Council of Scientific & Industrial ResearchInventors: Braja Gopal Hazra, Padmakar Laxman Joshi, Tirunahari Pavan Kumar
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Patent number: 6063731Abstract: Disclosed are compositions and methods for promoting plant growth. The compounds are cyclopropyl- and cyclobutyl-substituted brassinosteroids having high growth promoting ability. They may be used alone or in combination with other plant growth regulating agents.Type: GrantFiled: March 30, 1999Date of Patent: May 16, 2000Assignee: Agritope, Inc.Inventors: Thomas G. Back, Richard P. Pharis, Suanne K. Nakajima
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Patent number: 6011058Abstract: The present invention is directed to novel seco-cholestane derivatives, as well as to pharmaceutical compositions thereof, and methods of making the same. More particularly, the invention relates to C5- and C8-substituted seco-cholestane derivatives. The compounds of the invention can exhibit CDC25 phosphatase inhibition properties and anti-cancer activity.Type: GrantFiled: September 22, 1998Date of Patent: January 4, 2000Assignee: Georgia Tech Research CorporationInventors: Leon H. Zalkow, Hairuo Peng
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Patent number: 6008380Abstract: The present invention relates to a novel compound namely (2R,3S,24S)-2,3-diacetoxy-22,23-epoxy-24-ethyl-.beta.-homo-7-oxa-5.alpha.- cholestan-6-one and a process for the preparation thereof. The said compound is represented by the structural formula ##STR1## The said compound is a crucial intermediate in the synthesis of honobrassinolide having molecular formula C.sub.29 H.sub.50 O.sub.6.Type: GrantFiled: March 30, 1998Date of Patent: December 28, 1999Assignee: Council of Scientific & Industrial ResearchInventors: Braja Gopal Hazra, Padmakar Laxman Joshi, Tirunahari Pavan Kumar
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Patent number: 5998408Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.Type: GrantFiled: October 8, 1997Date of Patent: December 7, 1999Assignee: Merck & Co., Inc.Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, Andrew Kotliar, William H. Parsons, Kathleen M. Rupprecht
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Patent number: 5977165Abstract: The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.Type: GrantFiled: October 27, 1997Date of Patent: November 2, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsutomu Agatsuma, Yutaka Saitoh, Yoshinori Yamashita, Tamio Mizukami, Shiro Akinaga, Katsushige Gomi, Kazuhito Akasaka, Isami Takahashi
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Patent number: 5883119Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.Type: GrantFiled: October 16, 1996Date of Patent: March 16, 1999Assignee: Merck & Co., Inc.Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, William H. Parsons, Kathleen M. Rupprecht
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Patent number: 5786492Abstract: Halichondrin derivatives, isolatable from a marine sponge of the Lissodendoryx Sp., have cytotoxic preparations and are of the formula: ##STR1## wherein R.sup.1 and R.sup.Type: GrantFiled: July 29, 1997Date of Patent: July 28, 1998Assignee: Pharma Mar, S.A.Inventors: Dolores G. Gravalos, Robin J. Lake, John W. Blunt, Murray H. G. Munro, Marc S. P. Litaudon
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Patent number: 5763478Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.Type: GrantFiled: October 16, 1996Date of Patent: June 9, 1998Assignee: Merck & Co., Inc.Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, William H. Parsons, Kathleen M. Rupprecht
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Patent number: 5763366Abstract: Brassinosteroid derivatives expressed in formula (I) and formula (II) ##STR1## and a plant growth regulator containing one type or two types of these brassinosteroid derivatives as active ingredient.The invention thereby presents novel brassinosteroid analogous compounds expressed in formula (I) and formula (II) and a plant growth regulator containing these compounds showing a persisting plant growth regulating action.Type: GrantFiled: November 29, 1995Date of Patent: June 9, 1998Assignee: TAMA Biochemical Co. Ltd.Inventors: Suguru Takatsuto, Yasuo Kamuro, Tsuyoshi Watanabe, Hiroki Kuriyama
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Patent number: 5741814Abstract: Cyclooctadiene derivative of the following formula (1): ##STR1## wherein A.sup.1, A.sup.2, A.sup.3 and A.sup.4 each independently represent COOR.sup.5 (where R.sup.5 represents a hydrogen atom, a C.sub.1 -C.sub.10 alkyl group, a phenyl group, a C.sub.7 -C.sub.12 aralkyl group or CONR.sup.6 R.sup.7 (where R.sup.6 and R.sup.7 each independently represent a hydrogen atom, a C.sub.1 -C.sub.10 alkyl group or a phenyl group), or A.sup.1 and A.sup.2, and/or A.sup.3 and A.sup.4 may be combined together to represent group(s) of: ##STR2## in which X represents an oxygen atom or NR.sup.8 {where R.sup.8 represents a hydrogen atom, a C.sub.1 -C.sub.10 alkyl group or a phenyl group),R.sup.0, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a halogen atom, a hydroxyl group and an C.sub.1 -C.sub.10 alkyl group,the symbol ------ represents a single or double bond, and when it is a double bond, then R.sup.1 and R.sup.Type: GrantFiled: September 3, 1996Date of Patent: April 21, 1998Assignee: Nissan Chemical Industries, Ltd.Inventors: Yasuyuki Nakajima, Hisayuki Watanabe, Michiaki Adachi, Michito Tagawa, Mitsugu Futagawa, Takashi Furusato, Hiroshi Ohya, Masanori Nishioka
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Patent number: 5696156Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.Type: GrantFiled: October 16, 1996Date of Patent: December 9, 1997Assignee: Merck & Co. Inc.Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, William H. Parsons, Kathleen M. Rupprecht
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Patent number: 5679705Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.Type: GrantFiled: October 16, 1996Date of Patent: October 21, 1997Assignee: Merck & Co., Inc.Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, William H. Parsons, Kathleen M. Rupprecht
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Patent number: 5650430Abstract: Radicicol derivatives in which one or both hydroxy groups are acylated have valuable anti-tumor activity or may be used as chemical intermediates.Type: GrantFiled: June 7, 1995Date of Patent: July 22, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Kimio Iino, Yoshio Tsujita, Yoko Shimada, Tomowo Kobayashi, Takeshi Kagasaki
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Patent number: 5631282Abstract: Four triterpenes of Formula 1 (where "---" is either a single or double bond and R is H or acetate) are disclosed which are potent and selective immunosuppressive agents. These compounds have been isolated from Spachea correa root.Type: GrantFiled: June 7, 1995Date of Patent: May 20, 1997Assignee: Merck & Co., Inc.Inventor: Michael A. Goetz
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Patent number: 5597846Abstract: A compound of the formula ##STR1## in which: R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen atoms and groups of formula R.sup.3 --CO--, wherein R.sup.3 represents a group selected from the group consisting of unsubstituted alkyl groups having from 9 to 20 carbon atoms; substituted alkyl groups having from 10 to 20 carbon atoms; unsubstituted alkenyl groups having from 9 to 20 carbon atoms; substituted alkenyl group having from 10 to 20 carbon atoms; unsubstituted alkynyl groups having from 8 to 10 carbon atoms; and substituted alkynyl groups having from 8 to 10 carbon atoms wherein R.sup.1 and R.sup.2 are not both hydrogen atoms or acetyl groups. The compounds have antitumor activity.Type: GrantFiled: September 23, 1994Date of Patent: January 28, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Kimio Iino, Yoshio Tsujita, Yoko Shimada, Tomowo Kobayashi, Takeshi Kagasaki
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Patent number: 5508444Abstract: Novel substituted cis-1,2-dihydroxy-cyclohexadiene compounds, useful as intermediates in the production of compounds for use as intermediates in the production of agrochemicals and pharmaceuticals, and a microbial process for the preparation thereof.Type: GrantFiled: November 17, 1994Date of Patent: April 16, 1996Assignee: Zeneca LimitedInventors: Andrew J. Blacker, Martin Brown, Martin C. Bowden
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Patent number: 5494930Abstract: Compound (1), isolated from a marine dinoflagellate, is a novel macrolide which has potent in vitro cytotoxicity against human colon carcinoma cell line HCT116 (IC.sub.50 =1.6 nM) and a multiple drug resistant subline. In addition, this compound has good in vivo antitumor activity against a P388 mouse leukemia (150% T/C).Type: GrantFiled: June 2, 1994Date of Patent: February 27, 1996Inventors: Yuzuru Shimizu, Craig R. Fairchild
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Patent number: 5436238Abstract: Novel chemical compounds that can be used to synthesize halichondrin B and norhalichondrin B, and related derivatives. The total synthesis of halichondrin B and norhalichondrin B is also disclosed.Type: GrantFiled: March 12, 1993Date of Patent: July 25, 1995Assignee: President and Fellows of Harvard CollegeInventors: Yoshito Kishi, Francis G. Fang, Craig J. Forsyth, Paul M. Scola, Suk K. Yoon
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Patent number: 5350763Abstract: Unguinol is a well-known metabolite of the fungi Aspergillus unguis and Aspergillus nidulans. Unguinol has been found to be an active growth permittant and promotant in animals, in particular, monogastric animals such as chickens. In addition, the fermentation broth also produced the additional known unguinol derivatives of folipastatin and 2-chloro unguinol as well as the novel 4-methyl derivative. All of these compounds are active animal growth permittants. Compositions containing such unguinol derivatives for use as growth permittants and promotants are also disclosed.Type: GrantFiled: June 11, 1993Date of Patent: September 27, 1994Assignee: Merck & Co., Inc.Inventors: Scott D. Feighner, Gino M. Salituro, Jack L. Smith, Nancy N. Tsou
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Patent number: 5340807Abstract: Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, nitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR.sup.9 R.sup.10 CO.sub.2 R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 independently represents hydrogen or C1-6 alkyl) or CONR.sup.12 R.sup.13 (wherein each of R.sup.12 and R.sup.13 independently represents hydrogen or C1-6 alkyl); R.sup.5 represents hydrogen or C1-6 alkyl; each of R.sup.6, R.sup.7 and R.sup.8 independently represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y.sup.1 -Y.sup.2 represents CH.sub.2 --O, CH.sub.2 --(O).sub.n, (wherein n represents 0, 1, or 2), CH.sub.2 CH.sub.2, CH.dbd.CH or CON(R.sup.14) (wherein R.sup.Type: GrantFiled: December 11, 1992Date of Patent: August 23, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiaki Kumazawa, Masashi Yanase, Hiroyuki Harakawa, Hiroyuki Obase, Shoji Oda, Shiro Shirakura, Koji Yamada, Kazuhiro Kubo
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Patent number: 5298666Abstract: The invention provides a method for converting a lactone of a diamondoid compound to the hydroxyketone of the diamondoid compound wherein the hydroxyl group and the carbonyl group are separated by at least one bridgehead carbon comprising reacting an anhydride containing from about 2 to about 20 carbon atoms with the lactone of the diamondoid compound in the presence of acid.Type: GrantFiled: September 18, 1992Date of Patent: March 29, 1994Assignee: Mobil Oil CorporationInventor: Dong-Ming Shen
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Patent number: 5239064Abstract: A novel antibiotic complex, A59770, individual factors and derivatives thereof, are provided. The A59770 compounds are useful as pesticides, particularly as rodenticides. Further provided are methods for reducing a rodent population, rodenticidal compositions, and an A59770-producing Amycolatopsis orientalis culture.Type: GrantFiled: April 11, 1990Date of Patent: August 24, 1993Assignee: Eli Lilly and CompanyInventors: Marvin M. Hoehn, Karl H. Michel, Raymond C. Yao
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Patent number: 5225554Abstract: A process for synthesizing polyoxa tetracyclics which involves the ozonolysis of a single-ring-structure vinyl silane with resulting direct formation of the desired multiple ring material. The polyoxa tetracyclic compounds have the formula ##STR1## The vinyl silanes have the structure ##STR2## The vinyl silanes are new chemical compounds as are corresponding primary ozonide and dioxetane intermediates. In a preferred embodiment, this invention provides a total synthesis of the antimalarial artemisinin.Type: GrantFiled: July 18, 1990Date of Patent: July 6, 1993Assignee: SRI InternationalInventors: Mitchell A. Avery, Clive Jennings-White
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Patent number: 5055596Abstract: Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen or optionally protected hydroxy; R.sup.2 is alkoxy, optionally protected hydroxy, oxo or optionally O-substituted oximino; R.sup.3 is hydrogen, optionally protected hydroxy, or a group 4'-(.alpha.-L-oleandrosyl)-.alpha.-L-oleandrosyloxy or .alpha.-L-oleandrosyloxy wherein the terminal hydroxy group is optionally protected; one or R.sup.4 and R.sup.5 is hydrogen and the other is methyl; and one of R.sup.6 and R.sup.7 is hydrogen and the other is methyl; with the proviso that (a) when R.sup.1 is optionally protected hydroxy, R.sup.3 is hydrogen, and (b) when R.sup.2 is not methoxy or optionally protected hydroxy, R.sup.1 and R.sup.3 are both hydrogen, are new and useful as anthelmintic agents.Type: GrantFiled: July 30, 1990Date of Patent: October 8, 1991Assignee: Beecham Group p.l.c.Inventors: Geoffrey H. Baker, Roderick J. Dorgan, David O. Morgan, Rhona M. Banks, Simon E. Blanchflower, Mark E. Poulton, Peter R. Shelley
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Patent number: 5030650Abstract: There are provided certain 13-halo-23-imino-LL-F28249 compounds which are useful for controlling endo- and ectoparasites, insects, acarids and nematodes.Type: GrantFiled: September 11, 1989Date of Patent: July 9, 1991Assignee: American Cyanamid CompanyInventors: Brian L. Buckwalter, Shin-Shyong Tseng