Lactones (i.e., -c(=x)o-, Wherein X Is Chalcogen, Is Part Of The Hetero Ring) Patents (Class 549/263)
  • Patent number: 10828371
    Abstract: A multifunctionalized polycaprolactone polymer, a process for forming a multifunctionalized polycaprolactone polymer, and an article of manufacture comprising a material containing a multifunctionalized polycaprolactone polymer are disclosed. The multifunctionalized polycaprolactone polymer includes at least two functional groups. The process of forming the multifunctionalized polycaprolactone polymer includes forming a caprolactone monomer having at least two functional groups, and polymerizing the caprolactone monomer. Further, the article of manufacture includes a polycaprolactone polymer having at least two functional groups.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: November 10, 2020
    Assignee: International Business Machines Corporation
    Inventors: Eric J. Campbell, Sarah K. Czaplewski-Campbell, Brandon M. Kobilka, Jason T. Wertz
  • Patent number: 9630953
    Abstract: The present invention provides a small compound targeting at TACC3. The present invention further provides a drug, particularly, an anticancer agent, comprising the small compound targeting at TACC3. A compound represented by the general formula (I) or a pharmaceutically acceptable salt, solvate, or ester derivative thereof binds to TACC3 and inhibits cell growth. Thus, these compounds can be used as drugs, particularly, anticancer agents.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: April 25, 2017
    Assignee: JAPANESE FOUNDATION FOR CANCER RESEARCH
    Inventors: Ryoji Yao, Hiroyuki Osada, Yasumitsu Kondoh
  • Patent number: 9512138
    Abstract: Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 6, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Márquez-Garbán, Gang Deng
  • Patent number: 9399210
    Abstract: The invention relates to a method of producing an ethylenically unsaturated carboxylic acid or ester, preferably an ?, ? ethylenically unsaturated carboxylic acid or ester. The method includes contacting formaldehyde or a suitable source thereof with a carboxylic acid or ester in the presence of a catalyst and optionally in the presence of an alcohol. The catalyst comprises a nitrided metal oxide having at least two types of metal cations, M1 and M2, wherein M1 is selected from the metals of group 2, 3, 4, 13 (called also IIIA) or 14 (called also IVA) of the periodic table and M2 is selected from the metals of groups 5 or 15 (called also VA) of the periodic table. The invention extends to a catalyst system.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: July 26, 2016
    Assignee: LUCITE INTERNATIONAL UK LIMITED
    Inventors: Ian Andrew York, Sabina Ziemian
  • Patent number: 9388378
    Abstract: A strain of Candida sake, CAT H430, is provided. The methods of using CAT H430 for producing dicarboxylic acids are also provided.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: July 12, 2016
    Assignees: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.
    Inventors: Charlie Liu, Jinxiu Liao, Jianglin Wang, Haibin Qin, Naiqiang Li
  • Patent number: 9096510
    Abstract: The methods of the present invention comprise the steps of: providing a feedstock stream comprising an epoxide and carbon monoxide; contacting the feedstock stream with a metal carbonyl in a first reaction zone to effect conversion of at least a portion of the provided epoxide to a beta lactone; directing the effluent from the first reaction zone to a second reaction zone where the beta lactone is subjected to conditions that convert it to a compound selected from the group consisting of: an alpha beta unsaturated acid, an alpha beta unsaturated ester, an alpha beta unsaturated amide, and an optionally substituted polypropiolactone polymer; and isolating a final product comprising the alpha-beta unsaturated carboxylic acid, the alpha-beta unsaturated ester, the alpha-beta unsaturated amide or the polypropiolactone.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: August 4, 2015
    Assignee: NOVOMER, INC.
    Inventors: Richard V. Porcelli, Jay J. Farmer, Robert E. Lapointe
  • Publication number: 20150099800
    Abstract: The invention provides for novel lipase inhibitors, and compositions and devices comprising the same. The invention further provides for methods for treatment of disorders comprising administration of novel diacylglycerol lipase inhibitors, and compositions and devices comprising said inhibitors. In some embodiments, the disorders are pancreatitis, obesity, shock or pancreatic necrosis. The invention further provides for novel ether lipid reporter compounds and methods of assaying enzymatic activity comprising contacting a compound with a novel ether lipid reporter compound.
    Type: Application
    Filed: May 24, 2013
    Publication date: April 9, 2015
    Inventor: Richard I. Duclos, JR.
  • Patent number: 8969410
    Abstract: A pharmaceutical composition for alleviating or treating gout and the applications thereof are provided. The pharmaceutical composition includes p-coumaryl diacetate as an active ingredient.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: March 3, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Ying-Chu Shih, Jenn-Line Sheu, Cheng-Yu Lee, Jir-Mehng Lo, Yi-Ching Lee, Ying-Fei Tsai, Yi-Cheng Cheng
  • Publication number: 20150057455
    Abstract: Methods and systems for producing high purity 3-hydroxypropionic acid (3-HP) from an aqueous medium, such as a fermentation broth, are described. Aqueous 3-HP solution can be purified by flash evaporation wherein the 3-HP is vaporized at an elevated temperature without conversion to acrylic acid. This process can be integrated with downstream processes for producing other chemical and consumer products.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 26, 2015
    Inventors: Cindy HOPPE, Sarah M. HOYT, Robert TENGLER, David DeCOSTER, Bradley HARKRADER, Patrick H. AU-YEUNG, Sanjib BISWAS, Pedro R. VARGAS, II, Raymond P. ROACH, Timothy Charles FRANK
  • Publication number: 20140186873
    Abstract: Disclosed herein are isotopically labeled antifungal antibiotics and related compounds. Also disclosed are methods for synthesizing these isotopically labeled molecules and using the same to study the distribution of these compounds in the biosphere as well as the products formed by the breakdown of these isotopically labeled compounds.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 3, 2014
    Inventors: Ronald Ross, Jr., Peter Lee Johnson, Kevin G. Meyer
  • Publication number: 20140174682
    Abstract: Latent dispersants were made by the hydrogenation of an alkyl ketene dimer, alkenyl ketene dimer, or ketene multimer. Adding the latent dispersant to paper or paperboard increased its resistance to water and water vapor while maintaining recyclability and repulpability. Additionally, provided is a method for increasing the repulpability of a wax coated paper or paperboard. Dispersants made by the hydrolysis of the alkyl ketene dimer, alkenyl ketene dimer, and ketene multimer are also described.
    Type: Application
    Filed: October 23, 2013
    Publication date: June 26, 2014
    Applicant: HERCULES INCORPORATED
    Inventor: Clement L. Brungardt
  • Patent number: 8754242
    Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: June 17, 2014
    Assignees: Syngenta Crop Protection LLC, Syngenta Limited
    Inventors: Melloney Tyte, Christopher John Matthews, Gavin John Hall, William Guy Whittingham, Jeffrey Steven Wailes, James Nicholas Scutt, Stephane André Marie Jeanmart, Russell Colin Viner
  • Patent number: 8669375
    Abstract: PROBLEM To provide an environmentally-friendly method for producing industrially an ester compound. SOLUTION The present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: March 11, 2014
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Shigeaki Imazeki, Ryohiko Kinoshita
  • Patent number: 8637700
    Abstract: The present invention relates to a high-yield method for preparing highly pure (3S,4S)-4-((R)-2-(benzyloxy)tridecyl)-3-hexyl-2-oxetanone using a metal salt of (2S,3S,5R)-2-hexyl-3,5-dihydroxyhexadecanoic acid as an intermediate.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: January 28, 2014
    Assignee: Hanmi Science Co., Ltd
    Inventors: Sang Min Yun, Dong Jin Hong, Weon Ki Yang, Jae Ho Yoo, Ji Sook Kim, Moon Sub Lee, Han Kyong Kim, Eun Jung Lim, Young Ho Moon, Young-Kil Chang, Gwan Sun Lee
  • Publication number: 20140011903
    Abstract: In various embodiments a urethane/molecular rebar formulation comprising a specific composition is disclosed. The composition comprises a urethane polymer or prepolymer/discrete carbon nanotube formulation. Utility of the urethane/molecular rebar composition includes improved foams and adhesives.
    Type: Application
    Filed: July 8, 2013
    Publication date: January 9, 2014
    Inventors: Clive P. Bosnyak, Kurt W. Swogger
  • Patent number: 8623912
    Abstract: Novel Fostriecin (or FST) derivatives represented by formula (I), the pharmaceutical compositions and preparation methods thereof. The pharmaceutical uses of these compounds, especially the use for the preparation of pharmaceutical compositions for treating tumor, inhibiting cell over growth, or lowering myocardial infarction and the injury to cells.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: January 7, 2014
    Assignees: Beijing Biostar Technologies, Ltd., Dalian University of Technology
    Inventors: Li Tang, Rongguo Qiu
  • Patent number: 8604112
    Abstract: The invention relates to a composition containing a particulate solid, a plastic material (such as a thermoplastic polymer) and a compound capable of having dispersant properties. The compound may be obtained/obtainable by reacting a fatty acid with either (i) a hydroxy-C4-5-alkylene carboxylic acid, or (ii) a lactone. The invention further relates to novel compounds, and the use of the compound as a dispersant.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: December 10, 2013
    Assignee: The Lubrizol Corporation
    Inventors: Patrick J. Sunderland, Dean Thetford, Thomas Forder
  • Patent number: 8569362
    Abstract: The present invention relates to a polyketide molecule of the following formula (I): or a pharmaceutically acceptable salt thereof, where R1 is a hydrogen atom or a (C1-C7) alkyl group, as well as the method of preparation and use thereof, in particular as an anticancer agent.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: October 29, 2013
    Assignees: Pierre Fabre Medicament, Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Development (IRD)
    Inventors: Isabelle Carletti, Georges Massiot, Cécile Debitus
  • Publication number: 20130281490
    Abstract: The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.
    Type: Application
    Filed: November 21, 2012
    Publication date: October 24, 2013
    Inventors: The Regents of the University of California, Fondazione Istituto Italiano Di Tecnologia, Universita Degli Studi Di Parma, Universita Degli Studi Di Urbino "Carlo Bo"
  • Patent number: 8541606
    Abstract: A polymer compound for a photoresist composition (a) having a high dissolution rate in a developing solution after exposure and (b) exhibiting little swelling during development. A tertiary alcohol derivative that is a raw material for the polymer compound. A tertiary alcohol that is an intermediate of the tertiary alcohol derivative. The tertiary alcohol is represented by formula (3): wherein R1 and R2 individually represent a linear, branched or cyclic alkylene group having 2 to 9 carbon atoms, which may contain an oxygen atom, and wherein R1 and R2 may together form a ring with a carbon atom to which R1 and R2 are bonded.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: September 24, 2013
    Assignee: Kuraray Co., Ltd.
    Inventors: Takashi Fukumoto, Ichihiro Aratani
  • Patent number: 8481242
    Abstract: A salt represented by the formula (X): wherein Q1 and Q2, L1 and L2, ring W1, R5, w, v, Z+ and W10 are defined in the specification.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: July 9, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Ichikawa, Mitsuyoshi Ochiai, Masako Sugihara
  • Patent number: 8466298
    Abstract: Provided are a kind of high selectivity polymeric adsorbents with amide functional groups based on the hydrogen bonding interaction, which is prepared by adequately swelling a DVB-co-MA copolymer of 6% crosslinking degree as the initial resin with dimethyl formamide, performing an amination reaction by adding a diamine, soaking the dried resultant yellow resin with an acylating agent that is a dianhydride, and performing an acylation reaction to obtain the polymeric adsorbent with amide functional groups of the invention. The polymeric adsorbent of the invention can be used to effectively isolate and purify the active ingredients, i.e., flavones and lactones, from the extract of ginkgo leaf.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: June 18, 2013
    Assignee: Nankai University
    Inventors: Zhi Yuan, Chunhong Wang, Rongfu Shi, Jing Zhang, Ping Ren, Yingchao Chen
  • Patent number: 8440608
    Abstract: The invention relates, in particular to a tetrahydropyran(on) compound which is substituted in position beta with respect to a cycle oxygen of formula (I), wherein a substituent R is a linear alkyl radical in C2:C10 including, (CH3)2CH— or C6H5—(CH2)m—, with m=0 or 1, or formula (II), wherein A is —CH2— or —CO—, in the form of an odorant and to a method for the synthesis thereof by reducing oxo-ester. The use of the inventive compound in composition such as perfumery compositions in the ordinary sense of the term i.e. topic, in particular cosmetic compositions and care products.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: May 14, 2013
    Assignee: V. Mane Fils
    Inventors: Jean Mane, Jean-Jacques Chanot, Martin Schroeder
  • Publication number: 20130115661
    Abstract: A method for utilizing cultivated plant biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from cultivated plant biomass for producing derivative products while minimizing waste products.
    Type: Application
    Filed: November 9, 2011
    Publication date: May 9, 2013
    Applicant: THESIS CHEMISTRY, LLC
    Inventors: John R. Peterson, Christopher M. Yost, Jian Wu
  • Patent number: 8430948
    Abstract: The present invention relates to a condensation and washing device with which in particular the process vapors which occur during the production of polylactide can be processed and cleaned. Furthermore, the present invention relates to a polymerization device for the production of polylactide and also to a method for processing process vapors which occur during the production of polylactide; possibilities for use of both the condensation and washing devices and of the method are likewise mentioned.
    Type: Grant
    Filed: August 5, 2008
    Date of Patent: April 30, 2013
    Assignee: Uhde Inventa-Fischer GmbH
    Inventors: Rainer Hagen, Udo Muhlbauer
  • Patent number: 8404743
    Abstract: Disclosed are compounds comprising a zinc oxide molecule chemically bound to one or more molecules having an acidic hydrogen, such as an organic acid. The invention also provides compositions comprising such compounds and methods of preparing such compounds. The compounds of the invention may be provided in, for example, topical skin formulations, pharmaceutical compositions, or delivery systems for active ingredients.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: March 26, 2013
    Assignee: Mary Kay Inc.
    Inventor: James Swanzy
  • Publication number: 20130066070
    Abstract: To provide an environmentally-friendly method for producing industrially an ester compound. SOLUTION The present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.
    Type: Application
    Filed: October 23, 2012
    Publication date: March 14, 2013
    Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.
    Inventor: Wako Pure Chemical Industries, Ltd.
  • Publication number: 20130045897
    Abstract: An amphiphilic nanoparticle comprises a nanoparticle having a hydrophilic region comprising a hydrophilic functional group bonded to a first portion of a surface of the nanoparticle, and a hydrophobic region of a surface of the nanoparticle. A downhole fluid comprises the amphiphilic nanoparticle, and a method of controlling an oil spill using the downhole fluid are also disclosed.
    Type: Application
    Filed: August 19, 2011
    Publication date: February 21, 2013
    Applicant: BAKER HUGHES INCORPORATED
    Inventors: Soma Chakraborty, Gaurav Agrawal
  • Patent number: 8247213
    Abstract: Provided is a method for massive culture of Dinophysis acuminata which is a marine dinoflagellate causing diarrhetic shellfish poisoning, and methods for extracting, isolating and purifying the shellfish toxin pectenotoxin-2 from the cultured Dinophysis acuminata. Particularly, Dinophysis acuminata is cultured massively in massive culture apparatus comprising polycarbonate water bath having the bottom sinking down toward the center of the bottom; acryl tube (E) containing fluorescent lamp laid long in the center of the water bath; air supplying device (B) supplying the air to the sinking center of the bottom of the water bath; and air purifying device containing one or more devices selected from the group consisting of UV lamp (C) and carbon cartridge filter (D) purifying the air supplied by the said air supplying device.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: August 21, 2012
    Assignee: Industry-Academic Cooperation Foundation, Kunsan National University
    Inventors: WonHo Yih, Jung-Rae Rho, Hyung-Seop Kim, HeonJoong Kang
  • Publication number: 20120196740
    Abstract: Bi-functional cobalt-containing catalysts useful for making stereo specific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure ?-lactones from aldehydes and ketene are described. Precursors, intermediates, compositions, and particular features of the use if the compositions, such as high enantiomeric selectivity, high yield and low mole percent of catalyst useful are provided.
    Type: Application
    Filed: June 7, 2010
    Publication date: August 2, 2012
    Applicant: UNIVERSITY OF TOLEDO
    Inventor: Yun-Ming Lin
  • Patent number: 8177896
    Abstract: A novel chemical genus of furan-2-one antifouling compound as non-toxic, environment friendly antifouling agent, a coating material for objects submerged under the water based on the furan-2-one compounds. The substituted furan-2-one antifouling compounds have a furan-2-one ring and an alkyl side chain thereto and are of the formula: where n=6-14, representing the number of carbon atoms in said side chain.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: May 15, 2012
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Peiyuan Qian, Ying Xu, Xiaojian Zhou, Hongping He, Nobuhiro Fusetani, Wei-Min Dai
  • Patent number: 8148423
    Abstract: Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also herein are methods that can be used to track, measure, detect, or screen biological species such as protein, DNA, enzyme, antibody, organelle, cell, tissue, drug, hormone, nucleotide, nucleic acid, polysaccharide or lipid in living organisms. Specifically, the methods include the steps of contacting any of the fluorophore compounds, rhodol compounds and rhodamine compounds disclosed herein with the biological species to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening biological species.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: April 3, 2012
    Assignees: Versitech Limited, Morningside Ventures Limited
    Inventors: Dan Yang, Tao Peng
  • Patent number: 8124794
    Abstract: The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: February 28, 2012
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Jeffrey W. Smith, Fumiko Axelrod, Steven J. Kridel, Daniel Romo, Vikram Purohit, Gil Ma
  • Patent number: 8105746
    Abstract: (1) A polymer compound for photoresist composition which is high in dissolution rate in a developing solution after exposure and small swelling at the development and (2) a compound which is a raw material for such a polymer compound are provided. Furthermore, (3) a photoresist composition containing the subject polymer compound is provided. In detail, a tertiary alcohol derivative represented by the following general formula (1) is provided. (In the formula, R1 and R2 are taken together to form a ring together with a carbon atom to which R1 and R2 are bonded, and R1 and R2 as taken represent a linear, branched or cyclic alkylene group having from 2 to 9 carbon atoms, which may contain an oxygen atom at an arbitrary position; R3 represents a hydrogen atom or a methyl group; W represents a linear, branched or cyclic alkylene group having from 1 to 10 carbon atoms; and n represents 0 or 1.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 31, 2012
    Assignee: Kuraray Co., Ltd.
    Inventors: Takashi Fukumoto, Ichihiro Aratani
  • Publication number: 20110232178
    Abstract: Compounds and methods that release 1-methylcyclopropene, 1-trifluoromethylcyclopropene, and other substituted cyclopropenes are disclosed. The compounds and methods overcome present limitations for storage, transportation, and application of the cyclopropene containing compounds by using light, including sunlight, and/or heat as the primary release trigger. Additional products released include innocuous gases and value added aryl-group compounds.
    Type: Application
    Filed: March 23, 2011
    Publication date: September 29, 2011
    Inventors: John Perrin Davis, Cheryl D. Stevenson
  • Patent number: 8022041
    Abstract: This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: September 20, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Marion W. Wannamaker, Robert J. Davies
  • Publication number: 20110218346
    Abstract: Provided are a kind of high selectivity polymeric adsorbents with amide functional groups based on the hydrogen bonding interaction, which is prepared by adequately swelling a DVB-co-MA copolymer of 6% crosslinking degree as the initial resin with dimethyl formamide, performing an amination reaction by adding a diamine, soaking the dried resultant yellow resin with an acylating agent that is a dianhydride, and performing an acylation reaction to obtain the polymeric adsorbent with amide functional groups of the invention. The polymeric adsorbent of the invention can be used to effectively isolate and purify the active ingredients, i.e., flavones and lactones, from the extract of ginkgo leaf.
    Type: Application
    Filed: February 12, 2009
    Publication date: September 8, 2011
    Applicant: NANKAI UNIVERSITY
    Inventors: Zhi Yuan, Chunhong Wang, Rongfu Shi, Jing Zhang, Ping Ren, Yingchao Chen
  • Publication number: 20110196027
    Abstract: The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.
    Type: Application
    Filed: February 4, 2009
    Publication date: August 11, 2011
    Inventors: Stephan A. Sieber, Thomas Böttcher
  • Publication number: 20110172413
    Abstract: The present invention relates to a method for separating and purifying a lactone compound with an unsaturated alkyl group from a lactone compound with a saturated alkyl group which is an analog thereof. More specifically, the present invention relates to a method for effectively separating a lactone compound with an unsaturated alkyl group such as FK506 at high purity by extraction with a silver ion (Ag+) solution without use of column chromatography.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 14, 2011
    Applicant: GENOTECH CO., LTD
    Inventors: Jae Jong Kim, Si Kyu Lim, Mi Ok Lee, Sang Myoun Lim, Bo-mi Lee, Dong Hwan Kim, Keum Soon Lee, Jeoung Hyun Ryu
  • Patent number: 7977375
    Abstract: The invention relates to a novel antibiotic from the macrolactin group and a microbial method for production of macrolactins and a novel isolated Bacillus subtilis, of application as the producing strain for the known Macrolactin A and the novel derivative.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: July 12, 2011
    Assignee: Helmholtz-Zentrum Für Infektionsforschung GmbH
    Inventors: Kenneth N. Timmis, Gabriella Molinari, Rolf Jansen, Magally Romero-Tabarez, Dwi Andreas Santosa
  • Publication number: 20110160370
    Abstract: The invention relates to a composition containing a particulate solid, a plastic material (such as a thermoplastic polymer) and a compound capable of having dispersant properties. The compound may be obtained/obtainable by reacting a fatty acid with either (i) a hydroxy-C4-5-alkylene carboxylic acid, or (ii) a lactone. The invention further relates to novel compounds, and the use of the compound as a dispersant.
    Type: Application
    Filed: August 13, 2009
    Publication date: June 30, 2011
    Applicant: LUBRIZOL ADVANCED MATERIALS, INC.
    Inventors: Patrick J. Sunderland, Dean Thetford, Thomas Forder
  • Patent number: 7964635
    Abstract: The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: June 21, 2011
    Assignee: Novartis AG
    Inventors: Noëlle Gauvry, Thomas Goebel, Pierre Ducray, François Pautrat, Ronald Kaminsky, Martin Jung
  • Patent number: 7842410
    Abstract: A solid acid including a carbon nanotube (CNT), a spacer group combined with the CNT and an ionically conductive functional group connected to the spacer group. A polymer electrolyte membrane may include the same composition, and may be used in a fuel cell. The polymer electrolyte membrane using the solid acid has excellent ionic conductivity and suppresses the cross-over of methanol. The polymer electrolyte membrane is used as an electrolyte membrane of a fuel cell, for example, a direct methanol fuel cell.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 30, 2010
    Assignee: Samsung SDI Co., Ltd.
    Inventors: Jin-gyu Lee, Sang-kook Mah, Myung-sup Jung, Young-gyoon Ryu, Jae-jun Lee, Do-yun Kim
  • Patent number: 7825265
    Abstract: Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: November 2, 2010
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Roger Olsson, Lene Hyldtoft, Fabrice Piu, Magnus Gustafsson, Vladimir Sherbukhin, Birgitte Winther Lund
  • Publication number: 20100247475
    Abstract: Provided are a novel ?-glucuronidase inhibitor including a compound selected from a macrocyclic ketone, a ketone, a macrocyclic lactone, a macrocyclic oxalactone, an ester, an aldehyde, an alcohol, and a terpene of specific kinds, and an environmental hygiene product and a sanitary product each containing the ?-glucuronidase inhibitor. Also provided are a composition for suppressing the generation of urine odor and a method of suppressing the generation of urine odor each using a ?-glucuronidase inhibitor.
    Type: Application
    Filed: September 19, 2008
    Publication date: September 30, 2010
    Applicant: KAO CORPORATION
    Inventors: Ichiro Mori, Shunichi Akiba
  • Patent number: 7786057
    Abstract: Linked aromatic compounds found to act as potent soot dispersants in lubricating oil compositions; lubricating, oil compositions containing such soot dispersants and precursor compounds from which the soot dispersants are derived.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: August 31, 2010
    Assignee: Infineum International Limited
    Inventors: Tushar K. Bera, Jacob Emert, Jun Hua
  • Patent number: 7772408
    Abstract: Compositions of matter comprising 5-phenylalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or veterinary patients, including autoimmune diseases such as multiple sclerosis. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: August 10, 2010
    Assignee: The Regents of the University of California
    Inventors: Julia Vennekamp, Heike Wulff, K. George Chandy, Stephan Grissmer, Wolfram Hansel
  • Patent number: 7759044
    Abstract: A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: July 20, 2010
    Assignee: International Business Machines Corporation
    Inventors: Robert David Allen, Phillip Joe Brock, Richard Anthony DiPietro, Ratnam Sooriyakumaran, Hoa D. Truong
  • Publication number: 20100173982
    Abstract: The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.
    Type: Application
    Filed: November 17, 2009
    Publication date: July 8, 2010
    Applicant: The Burnham Institute for Medical Research
    Inventors: Jeffrey W. Smith, Fumiko Axelrod, Steven J. Kridel, Daniel Romo, Vikram Purohit, Gil Ma
  • Patent number: 7749679
    Abstract: A photosensitive composition containing a compound having a specific structure, a pattern-forming method using the photosensitive composition, and a compound having a specific structure used in the photosensitive composition.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: July 6, 2010
    Assignee: FUJIFILM Corporation
    Inventors: Kenji Wada, Kunihiko Kodama