Polycyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/31)
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Publication number: 20110117497Abstract: An acrylate derivative represented by the following general formula (1): (in the formula, R1 represents a hydrogen atom, a methyl group or a trifluoromethyl group; each of R2, R3, R5, R7, R8, R9 and R10 independently represents a hydrogen atom, an alkyl group, a cycloalkyl group or an alkoxy group; each of R4 and R6 independently represents a hydrogen atom, an alkyl group, a cycloalkyl group or an alkoxy group, or R4 and R6 are bonded to each other to represent an alkylene group, —O— or —S—; n represents 0, 1 or 2; and W represents an alkylene group or a cycloalkylene group); an intermediate thereof; a method for producing the same; a polymer compound which is obtainable from polymerization of a raw material containing the foregoing acrylate derivative and which is excellent in solubility in an organic solvent used for the preparation of a photoresist composition; and a photoresist composition containing the polymer compound, an organic solvent and a photo acid generator and having excellent adhesion to sType: ApplicationFiled: June 30, 2009Publication date: May 19, 2011Applicant: Kuraray Co., Ltd.Inventors: Junko Sato, Osamu Nakayama, Takashi Fukumoto
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Publication number: 20110053155Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.Type: ApplicationFiled: August 17, 2010Publication date: March 3, 2011Applicant: CEPHEIDInventor: Alexander A. Gall
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Patent number: 7816679Abstract: A field-effect transistor includes a channel-forming region composed of an organic compound crystal including ?-electron conjugated molecules each containing chalcogen atoms as a constituent, wherein the distance between chalcogen atoms of adjacent ?-electron conjugated molecules is short, and the organic compound crystal has a periodic structure in which ?-electron conjugated molecules are two-dimensionally or three-dimensionally linked together.Type: GrantFiled: July 30, 2008Date of Patent: October 19, 2010Assignee: Sony CorporationInventors: Akito Ugawa, Yousuke Ohta, Toshiyuki Kunikiyo, Masayuki Murakami
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Patent number: 7799931Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.Type: GrantFiled: February 17, 2009Date of Patent: September 21, 2010Assignee: Gruenenthal GmbHInventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
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Publication number: 20100210762Abstract: A compound represented by formula (I-1): wherein R21, R22, R23 and R24 each independently represent a hydrogen atom or a monovalent substituent, with the proviso that compounds, in which R21, R22, R23 and R24 each are an alkylthio group, are excluded; R21 and R22 and/or R23 and R24 each may bond to each other to form a ring, with the proviso that compounds, in which the formed ring is a dithiol ring or a dithiolane ring, are excluded; R25 and R26 each independently represent a hydrogen atom or a monovalent substituent; X21, X22, X23 and X24 each independently represent a hetero atom; compounds, wherein R21, R22, R23 and R24 each represent a cyan group; X21, X22, X23 and X24 each represent a sulfur atom; and R25 and R26 each represent a hydroxyl group or a hydrogen atom, are excluded; and compounds, wherein R21 and R23 each represent a hydrogen atom; R22 and R24 each represent an arylcarbonyl group; X21, X22, X23 and X24 each represent a sulfur atom; and R25 and R26 each represent a hydroxyl group, are eType: ApplicationFiled: August 15, 2008Publication date: August 19, 2010Applicant: FUJIFILM CORPORATIONInventors: Naoyuki Hanaki, Masuji Motoki, Toshihiko Yawata
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Publication number: 20100178609Abstract: A resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under action of an acid, and an acid generator component (B), wherein the base component (A) includes a polymeric compound (A0) containing a structural unit (a0) represented by the general formula (a0-1) shown below: (wherein, R1 represents a hydrogen atom, an alkyl group or a halogenated alkyl group; R2 represents a bivalent linking group containing at least one kind of polar groups selected from the group consisting of —O—, —C(?O)—, —C(?O)—O—, a carbonate linkage (—O—C(?O)—O—), —S—, —S(?O)2—, —S(?O)2—O—, —NH—, —NR04— (wherein, R04 represents an alkyl group or an acyl group), and —NH—C(?O)—; and R3 represents a cyclic group containing a sulfonyl group within the ring skeleton).Type: ApplicationFiled: January 11, 2010Publication date: July 15, 2010Applicant: TOKYO OHKA KOGYO CO., LTD.Inventors: Takahiro Dazai, Daiju Shiono, Tomoyuki Hirano, Tasuku Matsumiya, Daichi Takaki, Takayoshi Mori, Junichi Tsuchiya
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Patent number: 7745445Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.Type: GrantFiled: May 13, 2005Date of Patent: June 29, 2010Assignee: IRM LLCInventors: Robert Epple, Mihai Azimioara
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Patent number: 7736625Abstract: Photochemical demethylation reactions in solutions of thiazine dyes, in which the dye molecules act as both sensitizer and substrate, are reduced by quenching triple-state dye molecules, returning them to the unreactive ground state.Type: GrantFiled: December 8, 2008Date of Patent: June 15, 2010Assignee: Zila, Inc.Inventor: Douglas D. Burkett
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Patent number: 7732507Abstract: Spirotetrathiocarbamates (STOCs) or oxa substituted compounds (SOTOCs) of Formula I: Formula (I) or bisSTOC or bisSOTOC compounds of Formula II: Formula (II) wherein X1, X2, X3, X4, X5, X6, X7, and X8, are independently O or S; and preferably at least two and up to all four of X1, X2, X3 and X4, and at least two and up to all four of X5, X6, X7, and X8 are sulfur; Z is —CmR22m wherein m=1 to 4; —C(R2)2SC(R2)2—, C(R2)2SSC(R2)2—, or —C(R2)OC(R2)2; n is from 0 to 4; M is selected from CH2Cl, CH2SC(O)R1, CH2SC(S)R1, CH2S(CH2CH2S)qH wherein q is 0, 1 or 2; —CR2?CH2, —CH2OC(O)CR2?CH2, CH2N?C?S, CH2N?C?O, CH2NR2H, CH2OH, CH2SCH2CH2CR2?CH2, phenyl, C(R2)phenyl, furan, thiophene, halogen, C3-C6 cycloalkyl, C3-C6 heretocyclics, thiol, H, (III) or (IV) wherein A is S, O or phenyl; x is 0 or 1; R1 is C1-C22 alkyl; and R2 is H or C1-C22 alkyl have excellent optical properties. Methods for preparing these compositions and optical lenses prepared from the compounds are also provided.Type: GrantFiled: December 19, 2003Date of Patent: June 8, 2010Assignee: Essilor International Compagnie Generale d'OptiqueInventors: Aref Jallouli, Martin Rickwood, Kimberly Morgan, Sirisoma Wanigatunga
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Publication number: 20100136478Abstract: A resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the acid-generator component (B) including an acid generator (B1) containing a compound having a cation moiety represented by general formula (I) (in the formula, R5 represents an organic group having a carbonyl group, an ester bond or a sulfonyl group; and Q represents a divalent linking group).Type: ApplicationFiled: November 25, 2009Publication date: June 3, 2010Inventors: Akiya Kawaue, Yoshiyuki Utsumi, Hideo Hada, Takehiro Seshimo, Kensuke Matsuzawa, Keita Ishiduka, Kotaro Endo
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Publication number: 20100121077Abstract: A compound represented by general formula (I); and a compound represented by general formula (b1-1). wherein Q1 represents a divalent linkage group or a single bond; Y1 represents an alkylene group which may have a substituent or a fluorinated alkylene group which may have a substituent; X represents a cyclic group of 3 to 30 carbon atoms which may have a substituent, and has an —SO2— bond in the structure thereof; M? represents an alkali metal ion; and A+ represents an organic cation.Type: ApplicationFiled: January 22, 2010Publication date: May 13, 2010Applicant: TOKYO OHKA KOGYO CO., LTD.Inventors: Takehiro Seshimo, Yoshiyuki Utsumi, Akiya Kawaue, Hideo Hada, Hiroaki Shimizu, Tsuyoshi Nakamura
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Publication number: 20090240067Abstract: A method of producing a compound represented by formula (1), including: allowing 1,4-benzoquinone or 1,2-benzoquinone to react with a dithiocarbamate compound represented by formula (2) in a polar solvent: wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group, R1 and R2 may be the same or different and may be combined with each other to form a ring, X represents an ion necessary to neutralize the charge of the molecule, m represents an integer of 1 to 2, n represents an integer of 1 to 2, M represents a hydrogen atom, a metal atom or a conjugate acid of a base, p represents an integer of 1 to 4, and q represents an integer of 1 to 4.Type: ApplicationFiled: March 20, 2009Publication date: September 24, 2009Applicant: FUJIFILM CorporationInventors: Masuji Motoki, Toshihiko Yawata, Naoyuki Hanaki, Tomoaki Nakamura
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Publication number: 20090240014Abstract: Fluorinated compounds of the invention are represented by the following general formula (I). [In formula (I), Ar1 and Ar2 each independently represent a C10 or greater aromatic hydrocarbon or C4 or greater heterocyclic group, R1 represents hydrogen or a monovalent substituent, R2 and R3 each independently represent a monovalent substituent, and s1 and t1 each independently represent an integer of 0 or greater. When s1 is 2 or greater, the multiple R2 groups may be the same or different, and when t1 is 2 or greater the multiple R3 groups may be the same or different.Type: ApplicationFiled: February 22, 2007Publication date: September 24, 2009Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Yutaka Ie, Yoshio Aso, Masashi Nitani, Masato Ueda
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Publication number: 20090214432Abstract: The invention relates to new radicals, their use as paramagnetic agents in a method for the dynamic nuclear polarisation and a method for the dynamic nuclear polarisation of compounds comprising carboxyl groups.Type: ApplicationFiled: July 28, 2005Publication date: August 27, 2009Inventor: Mikkel Thaning
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Patent number: 7576224Abstract: Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives of Formula I are disclosed. These compounds provide unexpected insecticidal activity across a spectrum of insect pests combined with desirable physical properties including improved photostability. wherein x and y are integers independently selected from 0 or 1; and B is a bridging group *—(CR16R17)q—(CR18R19)r—(CR20R21)s-Lt-(CR22R23)u—(CR24R25)v—(CR26R27)w—, where the asterisk denotes attachment at A; and q, r, s, u, v and w are integers independently selected from 0, 1 and 2; and t is an integer selected from 0 and 1. A, D, E, G, M, R through R11, and R16 through R27, inclusively, are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I and methods of controlling insects by applying said compositions to a locus where insects are present or are expected to be present are also disclosed.Type: GrantFiled: December 1, 2005Date of Patent: August 18, 2009Assignee: FMC CorporationInventors: George Theodoridis, Edward J. Barron, Dominic P. Suarez, Y. Larry Zhang, Ping Ding, David M. Roush, Stephen F. Donovan, Frank J. Zawacki, Walter H. Yeager, John W. Lyga, Daniel H. Cohen
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Publication number: 20090130597Abstract: A compound represented by general formula (I); and a compound represented by general formula (b1-1). X-Q1-Y1—SO3?M+??[Chemical Formula 1] (I) X-Q1-Y1—SO3?A+ (b1-1) wherein Q1 represents a divalent linkage group or a single bond; Y1 represents an alkylene group which may have a substituent or a fluorinated alkylene group which may have a substituent; X represents a cyclic group of 3 to 30 carbon atoms which may have a substituent, and has an —SO2— bond in the structure thereof; M+ represents an alkali metal ion; and A+ represents an organic cation.Type: ApplicationFiled: November 5, 2008Publication date: May 21, 2009Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Takehiro Seshimo, Yoshiyuki Utsumi, Akiya Kawaue, Hideo Hada, Hiroaki Shimizu, Tsuyoshi Nakamura
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Patent number: 7528176Abstract: Carbonyl-functionalized oligo/polythiophene compounds, and related semiconductor components and related device structures.Type: GrantFiled: September 14, 2005Date of Patent: May 5, 2009Assignee: Northwestern UniversityInventors: Tobin J. Marks, Antonio Facchetti
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Patent number: 7425722Abstract: A field-effect transistor includes a channel-forming region composed of an organic compound crystal including ?-electron conjugated molecules each containing chalcogen atoms as a constituent, wherein the distance between chalcogen atoms of adjacent ?-electron conjugated molecules is short, and the organic compound crystal has a periodic structure in which ?-electron conjugated molecules are two-dimensionally or three-dimensionally linked together.Type: GrantFiled: June 14, 2005Date of Patent: September 16, 2008Assignee: Sony CorporationInventors: Akito Ugawa, Yousuke Ohta, Toshiyuki Kunikiyo, Masayuki Murakami
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Publication number: 20080125586Abstract: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods.Type: ApplicationFiled: December 10, 2007Publication date: May 29, 2008Applicant: INVITROGEN CORPORATIONInventors: Lewis R. Makings, Gregory Zlokarnik
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Patent number: 7268132Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.Type: GrantFiled: April 28, 2005Date of Patent: September 11, 2007Assignee: Cephalon, Inc.Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo
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Patent number: 7192982Abstract: Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length.Type: GrantFiled: May 30, 2002Date of Patent: March 20, 2007Assignees: Ligand Pharmaceuticals, Inc., Eli Lilly and CompanyInventors: Dawn Alisa Brooks, Alan M. Warshawsky, Chahrzad Montrose-Rafezadeh, Anne-Reifel Miller, Lourdes Prieto, Isabel Rojo, Jose Alfredo Martin, Maria Rosario Gonzales Garcia, Alicia Torrado, Rafael Ferritto Crespo, Carlos Lamas-Peteira, Robert J. Ardecky, Maria Martin-Ortega Finger
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Patent number: 7183311Abstract: The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-? phosphorylation of I?B. In yso doing these aminothiophene inhibitors block pathological activation of transcription factor NF-?B in which diseases excessive activation of NF-?B is implicated.Type: GrantFiled: April 11, 2003Date of Patent: February 27, 2007Assignee: SmithKline Beecham CorporationInventors: James F. Callahan, Yue H. Li
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Patent number: 6800380Abstract: An organometallic luminescent material comprising the compound of formula (I) of the present invention can emit pure blue light and have high thermal stability: wherein, M1 is a monovalent or tetravalent metal selected from the group consisting of Li, Na, K, Zr, Si, Ti, Sn, Cs, Fr, Rb, Hf, Pr, Pa, Ge, Pb, Tm and Md; R is hydrogen or C1-10 alkyl; B is O, S, Se or Te; D is O or S; and n is an integer ranging from 1 to 4.Type: GrantFiled: November 26, 2001Date of Patent: October 5, 2004Assignee: Nessdisplay Co., Ltd.Inventors: Youngkyoo Kim, Jae-Gyoung Lee
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Patent number: 6764777Abstract: The compound represented by the general formula (I): wherein each of R1 to R12 and RA1 to RA6 represents a hydrogen atom or a substituent group, and adjacent groups of R1 to R11 and RA1 to RA6 may be bonded to each other to form a ring. The light-emitting device of the present invention comprises a pair of electrodes and one or more organic layers disposed therebetween, at least one of the organic layers comprising the above compound.Type: GrantFiled: February 14, 2003Date of Patent: July 20, 2004Assignee: Fuji Photo Film Co., Ltd.Inventor: Toshihiro Ise
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Patent number: 6670358Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.Type: GrantFiled: October 26, 2001Date of Patent: December 30, 2003Assignee: Cephalon, Inc.Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
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Patent number: 6660764Abstract: The present application relates to new carboxylic acid amides of general formula wherein A, B and R1 to R3 are defined as in claim 1, processes for preparing them, pharmaceutical compositions containing these compounds and the use thereof and their preparation.Type: GrantFiled: December 19, 2001Date of Patent: December 9, 2003Assignee: Boehringer Ingelheim Pharma KGInventors: Norbert Hauel, Henning Priepke, Klaus Damm, Andreas Schnapp
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Patent number: 6566529Abstract: This invention pertains to DTT-based compounds having two-photon absorption property containing electron donors and/or electron acceptors and having cross section value &sgr; that is higher than compound AF-50.Type: GrantFiled: May 19, 2000Date of Patent: May 20, 2003Assignee: The United States of America as represented by the Secretary of the NavyInventors: Oh-Kil Kim, Han Young Woo, Kie-Soo Kim, Kwang-Sup Lee
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Publication number: 20030013041Abstract: Optical data carrier comprising a preferably transparent substrate which may, if desired, have previously been coated with one or more reflection layers and to whose surface a light-writeable information layer, if desired one or more reflection layers and if desired a protective layer or a further substrate or a covering layer have been applied, which can be written on or read by means of blue, red or infrared light, preferably laser light, where the information layer comprises a light-absorbent compound and, if desired, a binder, characterized in that at least one cationic aminoheterocyclic dye is used as light-absorbent compound.Type: ApplicationFiled: March 20, 2002Publication date: January 16, 2003Inventors: Horst Berneth, Friedrich-Karl Bruder, Wilfried Haese, Rainer Hagen, Karin Hassenruck, Serguei Kostromine, Peter Landenberger, Rafael Oser, Thomas Sommermann, Josef-Walter Stawitz, Thomas Bieringer
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Patent number: 6489489Abstract: Disclosed is a practical, organic, blue-emitting EL device having a long life and having high luminous efficiency and good thermal stability. The device comprises organic compound layers, of which at least one is an organic blue-emitting layer, as sandwiched between a pair of electrodes, and is characterized in that the organic blue-emitting layer comprises an organic host compound having a fluorescence quantum efficiency of not smaller than 0.3 in a solid state and a fluorescent substance, and the organic host compound and the fluorescent substance are selected such that the device retains a monomeric blue-emitting ability, and that all the organic compound layers have a glass transition temperature of not lower than 75° C., while the organic compound layers adjacent to the organic blue-emitting layer have a glass transition temperature of not lower than 105° C.Type: GrantFiled: February 8, 2001Date of Patent: December 3, 2002Assignee: Idemitsu Kosan Co., Ltd.Inventors: Toshio Sakai, Hisahiro Higashi, Hiroaki Nakamura, Hisayuki Kawamura, Chishio Hosokawa
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Patent number: 6472488Abstract: Polymerizable compositions from novel monomers that correspond to the formula: in which: Z represents H or CH3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms.Type: GrantFiled: September 20, 2001Date of Patent: October 29, 2002Assignee: Essilor International Compagnie Generale D'OptiqueInventors: Florence Caye, Michèle Sindt, Daniel Paquer, Dorothée Jury, Michel Schneider, Jean-Luc Mieloszynski
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Patent number: 6380235Abstract: The present invention provides compounds and pharmaceutical formulations useful as progesterone receptor agonists and antagonists and having the general formula: wherein: A is O, S, or NR4; B is a bond between A and C═Q, or the moiety CR5R6; R4, R5, R5 are independently selected from H or optionally substituted C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alknyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, or heterocyclic groups, or cyclic alkyl constructed by fusing R4 and R5 to from a 5 to 7 membered ring; R1 is selected from H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, substituted alknyl, —COH, or optionally substituted —CO(C1 to C3 alkyl), —CO(aryl), —CO(C1 to C3 alkoxy), or —CO(C1 to C3 aminoalkyl) groups; R2 is selected from H, halogen, CN, NO2, or optionally substituted C1 to C6 alkyl, C1 to C6 alkoxy, or C1 to C6 aminoalkyl groups; R3 is selected from a trisubstitutType: GrantFiled: April 19, 2000Date of Patent: April 30, 2002Assignees: American Home Products Corporation, Ligand Pharmaceuticals, Inc.Inventors: Puwen Zhang, Reinhold H. W. Bender, Jay E. Wrobel, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley
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Patent number: 6307062Abstract: The novel monomers correspond to the formula: in which: Z represents H or CH3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms.Type: GrantFiled: October 13, 1998Date of Patent: October 23, 2001Assignee: Essilor International Compagnie Generale d'OptiqueInventors: Florence Caye, Michèle Sindt, Daniel Paquer, Dorothée Jury, Michel Schneider, Jean-Luc Mieloszynski
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Patent number: 6294666Abstract: The invention relates to a method of preparing a compound of the following formula: wherein each of R1, R2, R3, and R4, independently, is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, alkoxy, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, or alkyloxyalkyl, provided that R1 and R2, optionally form a keto or, with the carbon atom to which they are attached, optionally form a cyclic moiety, and that R3 and R41, optionally form a keto or, with the carbon atom to which they are attached, optionally form a cyclic moiety.Type: GrantFiled: October 1, 1999Date of Patent: September 25, 2001Assignee: Academia SinicaInventor: Shang-Cheng Hung
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Patent number: 6211369Abstract: Spiro compounds of the formula (I), where X1, X2, X3, X4 are identical or different and are —S—, —O—, —NR5—, —CR5═N— or —CR5═CH—, with the proviso that at least one of the groups X1-4 is different from —CR5═CH—, are suitable as charge transport materials, in particular for photovoltaic cells, and as electroluminescence materials.Type: GrantFiled: January 3, 2000Date of Patent: April 3, 2001Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Josef Salbeck, Donald Lupo
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Patent number: 6093834Abstract: Preparation of perylene-3,4-dicarboxylic acid anhydrides of the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 can each be independently of one another hydrogen, halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.4 cycloalkyl, C.sub.1 -C.sub.20 alkoxy, phenyl, phenyloxy or phenylthio, where phenyl can in each case be mono- or polysubstituted by halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.14 cycloalkyl and/or C.sub.1 -C.sub.20 alkoxy; --NR.sup.5.sub.2 or --OR.sup.5, wherein R.sup.5 is hydrogen or C.sub.1 -C.sub.20 alkyl, or one of the pairs R.sup.1 /R.sup.2 and R.sup.3 /R.sup.4 each in 6,7- or 1,12-position is a bridge having the bridge atoms or bridge atom groups --O--, --S--, S.dbd.O, SO.sub.2 or --NR.sup.6, wherein R.sup.6 is hydrogen, C.sub.1 -C.sub.20 alkyl or C.sub.3 -C.sub.14 cycloalkyl, by treating a perylene-3,4-dicarboximide of formula II ##STR2## (a) in a first step with a base and, (b) in a second step, reacting the resultant anion with an alkylation agent R.sup.Type: GrantFiled: January 26, 1999Date of Patent: July 25, 2000Assignee: Ciba Specialty Chemicals CorporationInventor: Leonhard Feiler
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Patent number: 6063360Abstract: The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI contrast media.Type: GrantFiled: March 6, 1998Date of Patent: May 16, 2000Assignee: Nycomed Imaging A/SInventors: Sven Andersson, Finn Radner, Anna Rydbeck, Rolf Servin, Lars-Goran Wistrand, Mikkel Thaning
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Patent number: 6013810Abstract: Novel triarylmethyl free radicals, their use as image enhancing agents in MRI, in particular to their use in Overhauser enhanced MRI of a sample for determining oxygen concentration of said sample.Type: GrantFiled: June 25, 1997Date of Patent: January 11, 2000Assignee: Nycomed Imaging ASInventor: Mikkel Thaning
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Patent number: 5917056Abstract: The present invention relates to novel 10-deacetyl-14.beta.-hydroxybaccatine III derivatives. The novel derivatives, having cytotoxic and antitumour activity, are prepared from this synton after functionalization of the hydroxyls at 1-, 14- as thiocarbonate, iminocarbonate and sulfite and possible oxidation of the hydroxyl at C.sub.10. These derivatives are subjected to a subsequent esterification at position 13- with a variously substituted isoserine chain. The products of the invention can be administered by the injective or oral route, when suitably formulated.Type: GrantFiled: August 5, 1997Date of Patent: June 29, 1999Assignee: INDENA S.p.A.Inventor: Ezio Bombardelli
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Patent number: 5900490Abstract: Preparation of perylene-3,4-dicarboxylic acid anhydrides of the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 can each be independently of one another hydrogen, halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.14 cycloalkyl, C.sub.1 -C.sub.20 alkoxy, phenyl, phenyloxy or phenylthio, where phenyl can in each case be mono- or polysubstituted by halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.14 cycloalkyl and/or C.sub.1 -C.sub.20 alkoxy; --NR.sup.5.sub.2 or --OR.sup.5, wherein R.sup.5 is hydrogen or C.sub.1 -C.sub.20 alkyl, or one of the pairs R.sup.1 /R.sup.2 and R.sup.3 /R.sup.4 each in 6,7- or 1,12-position is a bridge having the bridge atoms or bridge atom groups --O--, --S--, S.dbd.O, SO.sub.2 or --NR.sup.6, wherein R.sup.6 is hydrogen, C.sub.1 -C.sub.20 alkyl or C.sub.3 -C.sub.14 cycloalkyl, by treating a perylene-3,4-dicarboximide of formula II ##STR2## (a) in a first step with a base and, (b) in a second step, reacting the resultant anion with an alkylation agent R.sup.Type: GrantFiled: January 14, 1998Date of Patent: May 4, 1999Assignee: Ciba Specialty Chemicals CorporationInventor: Leonhard Feiler
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Patent number: 5817639Abstract: The present invention provides a novel purine 4'-thioarabinonucleoside represented by the following formula ?1!: ##STR1## wherein B represents a purine base other than adenine. Also disclosed are a method for preparing the purine 4'-thioarabinonucleoside and pharmaceutical compositions containing the purine 4'-thioarabinonucleoside.Type: GrantFiled: July 12, 1996Date of Patent: October 6, 1998Assignee: Yamasa CorporationInventors: Mikari Watanabe, Yuichi Yoshimura, Shinji Sakata, Noriyuki Ashida, Haruhiko Machida
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Patent number: 5728370Abstract: The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI contrast media.Type: GrantFiled: June 6, 1995Date of Patent: March 17, 1998Assignee: Nycomed Imaging ASInventors: Sven Andersson, Finn Radner, Anna Rydbeck, Rolf Servin, Lars-Goran Wistrand
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Patent number: 5700448Abstract: The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based .pi.-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic resonance imaging (MRI), in particular electron spin resonance enhanced magnetic resonance imaging (ESREMRI). The invention also relates to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI and ESREMRI contrast media.Type: GrantFiled: April 3, 1995Date of Patent: December 23, 1997Assignee: Nycomed Imaging ASInventors: Klaes Golman, Sven Andersson, Frode Rise, Lars-Goran Wistrand, Hakan Wikstrom
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Patent number: 5693460Abstract: This invention provides a silver halide photographic element comprising a silver halide emulsion in reactive association with a dioxide compound represented by the following formula: ##STR1## wherein b is C(O), C(S), C(Se), CH2 or (CH2)2; and R.sup.1 and R.sup.2 are independently H, or aliphatic, aromatic or heterocyclic groups, or R.sup.1 and R.sup.2 together represent the atoms necessary to form a five or six-membered ring or a multiple ring system. This invention further provides a method of making silver halide emulsions containing the dioxide compounds.Type: GrantFiled: June 24, 1996Date of Patent: December 2, 1997Assignee: Eastman Kodak CompanyInventor: Roger Lok
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Patent number: 5591722Abstract: 2'-Deoxy-4'-thio-ribonucleosides, intermediates in their production, and their use as antiviral and anticancer agents are disclosed.Type: GrantFiled: December 12, 1994Date of Patent: January 7, 1997Assignee: Southern Research InstituteInventors: John A. Montgomery, John A. Secrist, III
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Patent number: 5530140Abstract: The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula ##STR1## (wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O).sub.n, (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or a S(O).sub.n group; R.sup.1 is a hydrogen atom or group of formula --M, --XM, --X--Ar.sup.2, or --Ar.sup.2 where M is a water solubilizing group, and Ar.sup.2 represents a 5-10 membered aromatic ring optionally substituted by a water solubilizing group M; and each of the groups R.sup.7, which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilizing group M, or two groups R.sup.Type: GrantFiled: March 31, 1994Date of Patent: June 25, 1996Assignee: Nycomed Imaging ASInventors: Sven Andersson, Finn Radner, Anna Rydbeek, Rolf Servin, Lars-Goran Wistrand
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Patent number: 5504217Abstract: Radical cation salts having the composition of formula I ##STR1## wherein x has a value from -0.1 to +0.2. These radical cation salts crystallize in needle form and are electric conductors. They can be incorporated in polymers to form conductive networks of crystal needles in a polymer matrix. The polymers can be used for making antistatically treated mouldings or electrodes.Type: GrantFiled: October 31, 1994Date of Patent: April 2, 1996Assignee: Ciba-Geigy CorporationInventors: Bruno Hilti, Ernst Minder, Carl W. Mayer, Bernd Klingert
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Patent number: 5498629Abstract: A compound of the general formula I: ##STR1## is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed.Type: GrantFiled: November 10, 1994Date of Patent: March 12, 1996Assignee: Ortho Pharmaceutical CorporationInventors: Michael J. Costenzo, Bruce E. Maryanoff, David F. McComsey, Samuel O. Nortey
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Patent number: 5446069Abstract: Disclosed are compounds of formula ##STR1## wherein F represents: ##STR2## or a pharmaceutically acceptable salt. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflamation.Type: GrantFiled: March 29, 1993Date of Patent: August 29, 1995Assignee: Schering CorporationInventors: Neng-Yang Shih, Pietro Mangiaracina, Michael J. Green, Ashit K. Ganguly
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Patent number: 5420299Type: GrantFiled: January 24, 1994Date of Patent: May 30, 1995Assignee: The University of SydneyInventors: Richard K. Haynes, Simone C. Vonwiller
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Patent number: 5384411Abstract: Disclosed are pH dyes containing a suitable compatible substituent which permits binding of the dye to a solid support. Also disclosed are methods for synthesizing such dyes prior to their coupling to the solid supports.Type: GrantFiled: June 20, 1991Date of Patent: January 24, 1995Assignee: Hewlett-Packard CompanyInventors: Karla M. Robotti, Carl A. Myerholtz