Acyclic Carbon Double Bonded Directly To A Ring Carbon Of A Four-membered Lactone Ring Patents (Class 549/327)
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Patent number: 8236136Abstract: Additives for paper making are disclosed herein. Specifically, the additives are wax-free alternatives to conventional coatings, including ASA, AKD and optionally an acrylic containing composition. Other additives may be included in the coating, such as cationic particles or compositions. The coatings may be used at a variety of points during the paper making process, including on the calender stack and in the wet end.Type: GrantFiled: February 25, 2010Date of Patent: August 7, 2012Assignee: Spectra-Kote CorporationInventors: Charles W. Propst, Jr., James C. Jones
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Patent number: 8124794Abstract: The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.Type: GrantFiled: November 17, 2009Date of Patent: February 28, 2012Assignee: Sanford-Burnham Medical Research InstituteInventors: Jeffrey W. Smith, Fumiko Axelrod, Steven J. Kridel, Daniel Romo, Vikram Purohit, Gil Ma
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Patent number: 7728153Abstract: The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.Type: GrantFiled: March 16, 2006Date of Patent: June 1, 2010Assignee: The Burnham Institute for Medical ResearchInventors: Jeffrey W. Smith, Fumiko Axelrod, Steven J. Kridel, Daniel Romo, Vikram Purohit, Gil Ma
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Patent number: 7232503Abstract: An internal size and a method for sizing board, such as liquid packaging board, with a hydrophobising internal size containing oxetanon derivative or 2-oxetanon. The main part of the hydrocarbon chains R? and R? of the oxetanon derivative or 2-oxetanon are derived from linear fatty acids, and ?20 w-%, typically 2 to 15 w-%, most typically 5 to 12 w-% of the hydrocarbon chains are derived from branched and mainly saturated fatty acids.Type: GrantFiled: April 10, 2002Date of Patent: June 19, 2007Assignee: Ciba Specialty Chemicals CorporationInventors: Markku Nurminen, Kenneth Sundberg, Claes Zetter
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Publication number: 20040149166Abstract: An internal size and a method for sizing board, such as liquid packaging board, with a hydrophobising internal size containing oxetanon derivative or 2-oxetanon. The main part of the hydrocarbon chains R′ and R″ of the oxetanon derivative or 2-oxetanon are derived from linear fatty acids, and ≦20 w-%, typically 2 to 15 w-%, most typically 5 to 12 w-% of the hydrocarbon chains are derived from branched and mainly saturated fatty acids.Type: ApplicationFiled: March 24, 2004Publication date: August 5, 2004Inventors: Markku Nurminen, Kenneth Sundberg, Claes Zetter
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Publication number: 20030166949Abstract: Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid.Type: ApplicationFiled: January 7, 2003Publication date: September 4, 2003Inventors: Leo E. Manzer, Keith W. Hutchenson
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Publication number: 20030158425Abstract: Alpha-methylenelactones are produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid in the presence of a catalyst and a phase transfer agent.Type: ApplicationFiled: January 7, 2003Publication date: August 21, 2003Inventors: Leo E. Manzer, Keith W. Hutchenson
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Publication number: 20020143195Abstract: This invention pertains to a process for making &agr;-methylenelactones and &agr;-substituted hydrocarbylidene lactones. More specifically, the present invention obtains high yields of &agr;-methylene-&ggr;-butyrolactone by heating &ggr;-butyrolactone and diethyl oxalate in the presence of a base. The second step comprises treatment of the &agr;-oxalyl enolate salt with formaldehyde to afford the &agr;-methylene-&ggr;-butyrolactone.Type: ApplicationFiled: December 21, 2001Publication date: October 3, 2002Inventors: Rutger D. Puts, Charles Brandenburg, Kenneth R. Tarburton
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Publication number: 20020038040Abstract: The present invention is directed towards a process for the preparation of enantiomerically enriched 4-hydroxymethyl-&ggr;-butyrolactone (I).Type: ApplicationFiled: August 24, 2001Publication date: March 28, 2002Inventors: Kai Rossen, Stefan Eils
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Patent number: 6342459Abstract: The present invention relates to photochromic 2H-naphtho[1,2-b]pyrans as well as their use in synthetic resins of all types, especially for ophthalmic purposes. In particular, the present invention relates to photochromic naphthopyran compounds, for which a further ring system is bonded to the f side of the naphthopyran. The inventive photochromic dyes generally have the general formula (I) wherein n, R1, R2, R3, X, B and B′ are defined as in claim 1. The inventive compounds are distinguished by good darkening and decolorizing properties and a very good service life.Type: GrantFiled: May 18, 2000Date of Patent: January 29, 2002Assignee: Optische Werke G. RodenstockInventors: Manfred Melzig, Claudia Mann, Udo Weigand
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Patent number: 6133184Abstract: A carrier containing silicon carbide, inorganic bonding component, and at least one oxide selected from the group consisting of a niobium oxide, an antimony oxide, and a tungsten oxide carries at least one oxide selected from the group consisting of a vanadium oxide and a molybdenum oxide as catalytically active component. An inexpensive catalyst for catalytic oxidation use can be thus offered that does not change its properties over a period of time, that boasts stable catalytic activity over a period of time, and that is suitable for, e.g., manufacture of an acid anhydride and a nitrile compound by conducting a catalytic gas-phase oxidation reaction (partial oxidation reaction) on a hydrocarbon.Type: GrantFiled: October 2, 1998Date of Patent: October 17, 2000Assignee: Nippon Shokubai Co., Ltd.Inventors: Yasushi Kiyooka, Masaaki Okuno
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Patent number: 5635382Abstract: A method is provided for enhancing transmembrane transport of exogenous molecules. The method comprises contacting a membrane of a living cell with a complex formed between said molecules and ligands selected from biotin, biotin analogs and other biotin receptor-binding ligands, and/or folic acid, folate analogs and other folate receptor-binding ligands to initiate receptor mediated transmembrane transport of the ligand complex. The method is used for the efficient delivery of peptides, proteins, nucleic acids and other compounds capable of modifying cell function into plant, animal, yeast, and bacterial cells.Type: GrantFiled: December 5, 1994Date of Patent: June 3, 1997Assignee: Purdue Research FoundationInventors: Philip S. Low, Mark A. Horn, Peter F. Heinstein
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Patent number: 4816477Abstract: The compounds of the following structural formula (I) ##STR1## ar 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.Type: GrantFiled: May 26, 1987Date of Patent: March 28, 1989Assignee: Merck & Co., Inc.Inventors: Narindar N. Girotra, Shu S. Yang, Donald W. Graham