Polycyclo Ring System Having One Of The Two Hetero Rings Which Form The Spiro As One Of The Cyclos Patents (Class 549/344)
  • Patent number: 9181152
    Abstract: The specification relates to compounds and process for the preparation of a compound of formula 7, where LG is a leaving group and hal is a halide and is Cl, Br or I. The compound of formula 7 can be useful in the preparation of natural products, such as halichondrin and its derivatives.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: November 10, 2015
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E. S. Souza, Huzaifa Rangwala, Boris Gorin, Ming Pan
  • Patent number: 8962859
    Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A1, A3, A5, A6, A8, R2, R7, X, Y and Z of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits and impairments, schizophrenia and other central nervous system conditions and disorders. The invention further provides compounds of Formulas II and III, and of sub-formulas of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: February 24, 2015
    Assignee: Amgen Inc.
    Inventors: Oleg Epstein, Ryan White, Vinod F. Patel, Jason Brooks Human
  • Publication number: 20150045529
    Abstract: The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
    Type: Application
    Filed: February 28, 2013
    Publication date: February 12, 2015
    Applicant: Merck Patent GmbH
    Inventors: Philipp Stoessel, Elvira Montenegro, Arne Buesing, Teresa Mujica-Fernaud, Joachim Kaiser
  • Patent number: 8921414
    Abstract: The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: December 30, 2014
    Assignee: EcoBiotics Ltd
    Inventors: Paul Warren Reddell, Victoria Anne Gordon
  • Publication number: 20140378645
    Abstract: A problem of the present invention is to provide a liquid crystal aligning agent which never deteriorates even in a method where UV is irradiated such as a liquid crystal dropping method or the like, and is capable of forming a liquid crystal alignment film having high UV resistance.
    Type: Application
    Filed: January 7, 2013
    Publication date: December 25, 2014
    Inventors: Atsushi Kozaki, Michihiko Sato
  • Publication number: 20140371285
    Abstract: Salinomycin analogs and pharmaceutically acceptable compositions containing salinomycin analogs. Dosage forms and kits comprising salinomycin analogs and pharmaceutically acceptable compositions containing salinomycin analogs. Methods of using salinomycin analogs, pharmaceutically acceptable compositions, dosage forms, and kits for the treatment of proliferative diseases, e.g.
    Type: Application
    Filed: January 7, 2013
    Publication date: December 18, 2014
    Inventors: Kevin Sprott, Michael Lewis, Hyeongwook Choi, Frank Fang, Mingde Shan, Tsvetelina I. Lazarova, Lin Li, M. Arshad Siddiqui, Robin Larouche-Gauthier, Alexandre Lemire
  • Publication number: 20140323744
    Abstract: The specification relates to compounds and process for the preparation of a compound of formula 7, where LG is a leaving group and hal is a halide and is Cl, Br or I. The compound of formula 7 can be useful in the preparation of natural products, such as halichondrin and its derivatives.
    Type: Application
    Filed: November 29, 2012
    Publication date: October 30, 2014
    Inventors: Fabio E.S. Souza, Huzaifa Rangwala, Boris Gorin, Ming Pan
  • Publication number: 20140319097
    Abstract: A phenolic monomer used in the lithographic process for semiconductor fabrication, a polymer for preparing a resist under-layer comprising the same, and a resist under-layer composition comprising the same, are disclosed.
    Type: Application
    Filed: November 1, 2012
    Publication date: October 30, 2014
    Inventors: Jeong-Sik Kim, Jae-Woo Lee, Jae-Hyun Kim
  • Publication number: 20140274930
    Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Evelyne Dietrich, Carl Poisson, Michel Gallant, Stephanie Lessard, Bingcan Liu, Sanjoy Kumar Das, Yeeman Ramtohul, Thumkunta Jagadeeswar Reddy, Julien Martel, Frederic Vallee, Jean-Francois Lévesque
  • Patent number: 8680141
    Abstract: The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: March 25, 2014
    Assignee: EcoBiotics Ltd
    Inventors: Paul Warren Reddell, Victoria Anne Gordon
  • Publication number: 20140080136
    Abstract: Provided are compositions, kits, and methods for detecting a vesicle comprising a membrane permeable marker that is converted into a detectable marker inside the vesicle.
    Type: Application
    Filed: April 4, 2013
    Publication date: March 20, 2014
    Inventors: Hyun-ju KANG, Ye-ryoung YONG, Myo-yong LEE
  • Publication number: 20130338219
    Abstract: The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g.
    Type: Application
    Filed: December 8, 2011
    Publication date: December 19, 2013
    Applicant: Intermed Discovery GMBH
    Inventors: Torsten Grothe, Marc Stadler, Bärbel Köpcke, Ernst Roemer, Jens Bitzer, Philipp Wabnitz, Thomas Küper
  • Patent number: 8569520
    Abstract: The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: October 29, 2013
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masatoshi Murakata, Takuma Ikeda, Nobuaki Kimura, Akira Kawase, Masahiro Nagase, Keisuke Yamamoto
  • Publication number: 20130274212
    Abstract: The present invention relates to sesterterpene compounds, to the precursors thereof that are hydrolysable in a living body, or to the pharmaceutically acceptable salts thereof, and also relates to the prevention and treatment efficacy of the sesterterpene compounds with respect to non-insulin dependent diabetes mellitus, diabetic complications (renal failure and foot ulcers caused by diabetes), alcoholic, non-alcoholic, and viral fatty liver diseases, obesity, hyperlipidemia, atherosclerosis, cardiovascular diseases such as atherosclerotic stroke, and cerebropathies (Parkinsonism, schizophrenia and Alzheimer's disease). In addition, the present invention relates to compositions for functional foods, functional beverages, functional cosmetics, and functional feed.
    Type: Application
    Filed: September 7, 2011
    Publication date: October 17, 2013
    Applicant: SNU R&DB FOUNDATION
    Inventors: Heon Joong Kang, Dong Hwan Won, In Ho Yang, Eun Oh Kim, Jung Ah Kim, Awadut Gajendra Giri, Venkat Reddy Mallepally
  • Patent number: 8546590
    Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: October 1, 2013
    Assignee: Cepheid
    Inventor: Alexander A. Gall
  • Patent number: 8466194
    Abstract: The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: June 18, 2013
    Assignee: EcoBiotics, Ltd
    Inventors: Paul Warren Reddell, Victoria Anne Gordon
  • Patent number: 8461358
    Abstract: A compound represented by the formula (I) or a salt thereof (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hydrogen atom, or an alkyl group; X represents a C1-C3 alkylene group; and R10 represents an acyl group), which promptly causes a structural change from a non-fluorescent closed ring structure to a strongly fluorescent open ring structure by hydrolysis of an acyl group, and is useful as a fluorescent probe for measuring a protease showing superior suitability for quantification.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: June 11, 2013
    Assignee: The University of Tokyo
    Inventors: Tetsuo Nagano, Yasuteru Urano, Masayo Sakabe
  • Patent number: 8389569
    Abstract: Novel polyspirane compounds used in the treatment of diseases involving parasites that belong to the phylum of apicomplexae, and a method for preparing the same.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: March 5, 2013
    Assignee: Universite Joseph Fourier
    Inventors: Yung-Sing Wong, Marine Aimée Peuchmaur, Eric Marechal, Cyrille Botte, Henri Joseph Vial, Nadia Saidani
  • Publication number: 20130023675
    Abstract: An agent for diagnosing cancer comprising, as an active ingredient, a compound represented by the following formula (I) (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hydrogen atom, or an alkyl group; and X represents a C1-C3 alkylene group), which specifically emits fluorescence in a cancerous tissue within a short time when applied to a part in which presence of a cancerous tissue is suspected.
    Type: Application
    Filed: January 12, 2011
    Publication date: January 24, 2013
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Yasuteru Urano, Tetsuo Nagano, Masayo Sakabe
  • Publication number: 20130004993
    Abstract: Methods for producing and obtaining natural products from microbial amplification chambers are described. This approach utilizes the concept of green chemistry to synthesize and extract the marine and terrestrial natural products. The method describes techniques to colonize and grow the selected bacteria and to continuously harvest the pharmaceutical agent from the broth without using any commercial solvents.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 3, 2013
    Applicants: University System of Georgia, Valdosta State University
    Inventor: Thomas J. Manning
  • Publication number: 20120329085
    Abstract: The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.
    Type: Application
    Filed: June 11, 2012
    Publication date: December 27, 2012
    Applicant: The Regents of The University of California
    Inventors: Christopher J. CHANG, Alexander R. Lippert, Vivian S. Lin
  • Publication number: 20120052518
    Abstract: A compound represented by the formula (I) or a salt thereof (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hydrogen atom, or an alkyl group; X represents a C1-C3 alkylene group; and R10 represents an acyl group), which promptly causes a structural change from a non-fluorescent closed ring structure to a strongly fluorescent open ring structure by hydrolysis of an acyl group, and is useful as a fluorescent probe for measuring a protease showing superior suitability for quantification.
    Type: Application
    Filed: February 19, 2010
    Publication date: March 1, 2012
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Tetsuo Nagano, Yasuteru Urano, Masayo Sakabe
  • Publication number: 20110306778
    Abstract: The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.
    Type: Application
    Filed: June 19, 2009
    Publication date: December 15, 2011
    Inventors: Masatoshi Murakata, Takuma Ikeda, Nobuaki Kimura, Akira Kawase, Masahiro Nagase, Keisuke Yamamoto
  • Publication number: 20110275703
    Abstract: The present invention provides a compound represented by Formula (II): wherein R1 is a chlorine atom, a fluorine atom, a methyl group or an ethynyl group; Ar is a group represented by the following Formula (a), Formula (b), Formula (c) or Formula (d): wherein R2 is a C1-6 alkyl group which may be substituted with one or more halogen atoms, a C1-6 alkoxy group which may be substituted with one or more halogen atoms, a C1-3 alkylthio group, a halogen atom, a C1-3 alkylcarbonyl group or a C2-5 alkynyl group which may be substituted with —OR4; R3 is a hydrogen atom or a C1-3 alkyl group; R4 is a hydrogen atom or a C1-3 alkyl group; provided that Ar is a group represented by Formula (a) when R1 is a fluorine atom, methyl group or an ethynyl group, and that R2 is methoxy group, an ethoxy group, an isopropyl group, a propyl group, a trifluoromethyl group, a trifluoromethoxy group, 2-fluoroethyl group or 1-propynyl group when R1 is a methyl group or a pharmaceutically acceptable salt or a solvate thereof a
    Type: Application
    Filed: July 27, 2007
    Publication date: November 10, 2011
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tsutomu Sato, Kiyofumi Honda, Takahiro Kawai, Koo Hyeon Ahn
  • Patent number: 8048496
    Abstract: The purpose the invention is to provide a polymerizable liquid crystal compound which has an excellent solubility with other compounds, a high homeotropic property, and a spirobiindan-backbone, and a liquid crystal composition comprising this compound. The purpose is attained with a polymerizable liquid crystal compound represented by Formula (1). A polymer which is excellent in many characteristics can be obtained from this compound and a formed body having optical anisotropy, produced from this polymer can be obtained. In Formula (1), G is a single bond or oxygen; R is hydrogen, methyl (Me) or a group represented by Formula (a), wherein at least two of R are groups represented by Formula (a); P is a polymerizable group represented by any of Formula (P1) to Formula (P8). In Formula (a), a desirable A is 1,4-cyclohexylene or 1,4-phenylene; Z is a bonding group; m is an integer of 0 to 3; X0 is a single bond or alkylene; Z0 is a single bond, —O—, —OCO—, or —OCOO—; X is a single bond or alkylene.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: November 1, 2011
    Assignee: JNC Corporation
    Inventors: Maiko Itoh, Yoshiharu Hirai, Junichi Inagaki, Daisuke Ootsuki
  • Publication number: 20110218240
    Abstract: Provided are a novel compound with a spiro chiral carbon backbone, a stereoisomer thereof, an enantiomer thereof, an in vivo hydrolysable precursor thereof, or a pharmaceutically acceptable salt thereof. The novel compound with the spiro chiral carbon backbone has excellent osteoblast differentiation activity, mast cell inhibitory activity, and fatty acid synthesis inhibitory activity in the liver. Therefore, the novel compound can be expected to play an innovative role in treatment of osteoporosis, fatty liver, and obesity.
    Type: Application
    Filed: October 30, 2009
    Publication date: September 8, 2011
    Applicant: SNU R & DB FOUNDATION
    Inventors: Heon-Joong Kang, Jung-Rae Rho, Jeong-Ho Hong, Seung-Bum Park, Chan-Soo Shin, Jae-Hwan Lee, Jun-Young Hong, Eun-O Kim, Jeong-Ah Kim, Sang-Mi Oh
  • Patent number: 8013012
    Abstract: The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: September 6, 2011
    Assignee: EcoBiotics Ltd
    Inventors: Paul Warren Reddell, Victoria Anne Gordon
  • Patent number: 7994215
    Abstract: High purity phthalein derivatives are useful for medical applications and/or in the field of biotechnology. The phthalein derivatives are prepared by a method whereby a phthalic anhydride derivative is condensed with a naphthol or phenol derivative in an organic acid ester and the crystals of the resulting condensate are converted by action of a strong acid or one of its precursors in anhydrous medium.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: August 9, 2011
    Assignee: Patent-Pharma
    Inventors: Joanne Tran-Guyon, Francois Scherninski
  • Publication number: 20110080458
    Abstract: There are described novel rhodamine dye compounds and imaging members and imaging methods, including thermal imaging members and imaging methods, utilizing the compounds. The dye compounds exhibit a first color when in the crystalline form and a second color, different from the first color, when in the liquid, amorphous form.
    Type: Application
    Filed: March 30, 2010
    Publication date: April 7, 2011
    Inventors: Kap-Soo Cheon, Stephen J. Telfer, Michael P. Filosa, John L. Marshall, Fariza B. Hasan, David A. Skyler, John M. Hardin
  • Publication number: 20110077389
    Abstract: Novel CE-phosphoramidites and CPG reagents have been synthesized from a serinol backbone. These reagents are useful to introduce functional groups or directly label oligonucleotides. The versatile serinol scaffold allows for labeling at any position (5? or 3? termini, or any internal position) during automated DNA synthesis. Multiple labels or functional groups can be achieved by repetitive coupling cycles. Optimal spacer arms and protected label moieties have been specially designed. Further, the natural 3-carbon atom internucleotide phosphate distance is retained when inserted internally.
    Type: Application
    Filed: September 28, 2010
    Publication date: March 31, 2011
    Applicants: Nelson Biotechnologies, Inc., Glen Research Corporation
    Inventors: Paul S. Nelson, Hugh Mackie, Andrew Murphy
  • Publication number: 20110053155
    Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.
    Type: Application
    Filed: August 17, 2010
    Publication date: March 3, 2011
    Applicant: CEPHEID
    Inventor: Alexander A. Gall
  • Publication number: 20100317027
    Abstract: The present invention provides compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agent)s; L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.
    Type: Application
    Filed: August 23, 2010
    Publication date: December 16, 2010
    Inventors: Leslie B. Poole, S. Bruce King, Jacquelyn S. Fetrow
  • Publication number: 20100298422
    Abstract: Novel polyspirane compounds used in the treatment of diseases involving parasites that belong to the phylum of apicomplexae, and a method for preparing the same.
    Type: Application
    Filed: October 2, 2008
    Publication date: November 25, 2010
    Applicants: UNIVERSITE JOSEPH FOURIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Yung-Sing Wong, Marine Aimee Peuchmaur, Eric Marechal, Cyrille Botte, Henri Joseph Vial, Nadia Saidani
  • Publication number: 20100234609
    Abstract: Provided are a compound represented by Formula (I): wherein R1, R2, R3, and R4 are each independently selected from a hydrogen atom, a C1-6 alkyl group which may be substituted, a C7-14 aralkyl group which may be substituted and —C(?O)Rx; n denotes an integer selected from 1 and 2; and ring Ar is selected from the groups represented by the following Formula (a) to (f). or a prodrug thereof or a pharmaceutically acceptable salt thereof as well as a pharmaceutical agent and a pharmaceutical composition containing such a compound or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 27, 2007
    Publication date: September 16, 2010
    Inventors: Tsutomu Sato, Yoshihito Ohtake, Masahiro Nishimoto, Takashi Emura, Takamitsu Kobayashi, Marina Yamaguchi, Kyouko Takami
  • Patent number: 7714149
    Abstract: The present invention provides a chiral ligand, represented by a formula or its enantiomer: X and X? can be independently O, NH, NR, NCOR or S; each of Z1-Z7 and Z1?-Z7? can be independently H, alkyl, aryl, substituted alkyl, substituted aryl, alkoxyl, aryloxyl, nitro, amide, aryoxide, halide, hydroxyl, carboxylate, hetereoaryl, or a cyclic alkene, fused aryl, or cyclic ether group formed from any two adjacent Z groups or any two adjacent Z? groups; Y and Y? can be independently OH, OR, NH2, NHR, NR2, SH, PR2, OPR2, NHPR2, OP(OR)2, COOH, COOR, CONHR, or a linking group formed from Y and Y? groups together. Processes of preparing these ligands, catalysts that employ them and methods of using the catalysts are also provided.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: May 11, 2010
    Assignee: The Penn State Research Foundation
    Inventor: Xumu Zhang
  • Patent number: 7589218
    Abstract: The present invention provides a chiral ligand, represented by a formula or its enantiomer: X and X? can be independently O, NH, NR, NCOR or S; each of Z1-Z7 and Z1?-Z7? can be independently H, alkyl, aryl, substituted alkyl, substituted aryl, alkoxyl, aryloxyl, nitro, amide, aryloxide, halide, hydroxyl, carboxylate, heteroaryl, or a cyclic alkene, fused aryl, or cyclic ether group formed from any two adjacent Z groups or any two adjacent Z? groups; Y and Y? can be independently OH, OR, NH2, NHR, NR2, SH, PR2, OPR2, NHPR2, OP(OR)2, COOH, COOR, CONHR, or a linking group formed from Y and Y? groups together. Processes of preparing these ligands, catalysts that employ them and methods of using the catalysts are also provided.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: September 15, 2009
    Assignee: The Penn State Research Foundation
    Inventor: Xumu Zhang
  • Publication number: 20090169483
    Abstract: The present invention relates to a endothelin receptor antagonist conjugate of the formula (I) wherein R2 is an alkoxy group and one of R1 and R3 represents an alkoxy group and the other represents a group of the formula: (OCH2CH2)n—NH—X, wherein n is an integer of 1 to 100 and X represents a fluorescent dye and tautomers thereof. Furthermore, the present invention relates to a diagnostic composition comprising the compounds of the invention. The present invention also relates to the use of the compounds of the invention for the preparation of a diagnostic composition for the diagnosis of cancer, the evaluation of cancer biology and/or monitoring of anticancer therapy. In a further aspect, the present invention relates to kits comprising the compounds of the invention.
    Type: Application
    Filed: September 6, 2006
    Publication date: July 2, 2009
    Inventors: Christoph Bremer, Carsten Höltke, Klaus Kopka, Michael Schäfers
  • Publication number: 20090137389
    Abstract: There are described novel rhodamine color-forming compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form. Thermal imaging members containing these color-formers are also described.
    Type: Application
    Filed: December 23, 2008
    Publication date: May 28, 2009
    Inventors: Kap-Soo CHEON, Michael P. Filosa, Fariza Hasan, Xavier Herault, John L. Marshall
  • Publication number: 20090104711
    Abstract: Disclosed herein are fluorescent markers having a double bond ester group and a method for marking and detecting the same. More particularly, disclosed are a method for identifying oil products, which comprises marking the oil products with fluorescent markers having an unsaturated double bond ester group, adding a developing agent having a function of inducing specific fluorescence to the marked oil products, and detecting the fluorescent marker with a fluorescence spectrophotometer in the UV/VIS region, as well as said markers.
    Type: Application
    Filed: July 28, 2006
    Publication date: April 23, 2009
    Inventor: Hyun-Ho Sim
  • Patent number: 7521004
    Abstract: A chromene compound of this invention, as shown in the following formula: characterized by having an indeno(2,1-f)naphtho(1,2-b)pyran structure as a basic structure, and having a substituent which is a substituted or unsubstituted aryl group such as methoxyphenyl group, or a substituted or unsubsterituted heteroaryl group such as thienyl group bonding to a carbon atom at the seventh position of the indeno(2,1-f)naphtho(1,2-b)pyran structure. The photochromic compound exhibits a color tone of a neutral tint when it develops a color, features a high color-developing sensitivity and a high fading rate, and has a good photochromic resistance.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: April 21, 2009
    Assignee: Tokuyama Corporation
    Inventors: Junji Momoda, Yuichiro Kawabata, Nobuyuki Tanaka, Arihiro Iwata
  • Patent number: 7518002
    Abstract: The invention concerns high purity phthalcin derivatives enabling their use for medical applications or in the field of biotechnology, as well as their preparation method whereby a phthatic anhydride derivative is condensed with a naphthol or phenol derivative in an organic acid ester and the crystals of the resulting condensate are converted by action of a strong acid or one of its precursors in anhydrous medium.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: April 14, 2009
    Assignee: Patent-Pharma
    Inventors: Joanne Tran-Guyon, François Scherninski
  • Publication number: 20090082428
    Abstract: The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.
    Type: Application
    Filed: December 22, 2006
    Publication date: March 26, 2009
    Applicant: ECOBIOTICS LTD
    Inventors: Paul Warren Reddell, Victoria Anne Gordon
  • Patent number: 7491832
    Abstract: The present invention provides a sulfonate compound including a structure represented by a general formula (I) below. In the formula (I), an atomic group A-O is an atomic group that forms a fluorescent compound upon cleavage of a covalent bond with a sulfonyl group. There may be one or plural atomic groups B—SO3— bound to an atomic group A. B is a ring substituted by one or plural electron-withdrawing groups. The electron-withdrawing group includes at least one selected from the group consisting of halogens, a carboxyl group, a carbamoyl group, a straight or branched alkylcarbamoyl group, a straight or branched alkanoyl group, a straight or branched alkoxycarbonyl group, a straight or branched alkyl halide group, and —NR3+ group (the three Rs each denote a hydrogen atom or a straight or branched alkyl group and may be the same or different). When there are plural Bs, the Bs may be the same or different.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: February 17, 2009
    Assignee: Osaka Industrial Promotion Organization
    Inventors: Hatsuo Maeda, Kazumasa Hirata, Kazuhisa Miyamoto
  • Publication number: 20090030006
    Abstract: The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(?O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical co
    Type: Application
    Filed: January 27, 2006
    Publication date: January 29, 2009
    Inventors: Takamitsu Kobayashi, Tsutomu Sato, Masahiro Nishimoto
  • Patent number: 7470376
    Abstract: The present invention relates to a phototunable chiral dopant represented by the following structure: wherein: A, B, C and D are independent divalent groups; X and Z are any independently selected substituent; n is an integer and independently varies from 0 to 3; q is an integer and independently varies from 0 to 5; RNG1 and RNG2 independently represent any ring group; m represents an integer independently varying from 0 to 4; p represents an integer independently varying from 1 to 4; Q independently represents a carbon C—RC, or nitrogen, wherein RC is independently hydrogen or any substituent. The invention also relates to the use of the dopant in a liquid crystalline composition and a display containing the same, as well as a material composition comprising an enantiomeric excess of one enantiomer of the compound.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: December 30, 2008
    Assignee: Industrial Technology Research Institute
    Inventors: Thomas R. Welter, Krishnan Chari
  • Patent number: 7465814
    Abstract: The present invention provides a sulfonate compound, including a structure represented by a general formula (I) below, where, in the formula (I), an atomic group A-O is an atomic group that forms a fluorescent compound upon cleavage of a covalent bond between the atomic group A-O and a sulfonyl group, one or a plurality of atomic groups B—SO3— are bonded to an atomic group A, B is a ring that is substituted by one or a plurality of electron-withdrawing groups, the electron-withdrawing group is at least one selected from the group consisting of an alkyl halide group, a nitro group and a cyano group, and B may be the same or different in kind in the case where the plurality of B exist.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: December 16, 2008
    Assignee: Osaka Industrial Promotion Organization
    Inventors: Hatsuo Maeda, Norio Itoh
  • Publication number: 20080293953
    Abstract: The present invention provides a chiral ligand, represented by a formula or its enantiomer: X and X? can be independently O, NH, NR, NCOR or S; each of Z1-Z7 and Z1?-Z7? can be independently H, alkyl, aryl, substituted alkyl, substituted aryl, alkoxyl, aryloxyl, nitro, amide, aryloxide, halide, hydroxyl, carboxylate, heteroaryl, or a cyclic alkene, fused aryl, or cyclic ether group formed from any two adjacent Z groups or any two adjacent Z? groups; Y and Y? can be independently OH, OR, NH2, NHR, NR2, SH, PR2, OPR2, NHPR2, OP(OR)2, COOH, COOR, CONHR, or a linking group formed from Y and Y? groups together. Processes of preparing these ligands, catalysts that employ them and methods of using the catalysts are also provided.
    Type: Application
    Filed: July 15, 2008
    Publication date: November 27, 2008
    Applicant: The Penn State Research Foundation
    Inventor: Xumu Zhang
  • Publication number: 20080280974
    Abstract: Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of an inflammatory condition, in particular asthma. The compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof: wherein Y, Z and R1-R12 are defined herein.
    Type: Application
    Filed: May 9, 2008
    Publication date: November 13, 2008
    Inventors: M. David Weingarten, Liming Ni, Zhihong Ye, Charles Q. Meng, Raymond Ng, Jim A. Sikorski
  • Patent number: 7323577
    Abstract: A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula: wherein R1 and R2 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula: WH wherein W is wherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R3 is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R4 is a hydrogen atom, an opt
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: January 29, 2008
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Hiroyuki Tawada, Makoto Yamashita, Yujiro Ono
  • Patent number: 7196191
    Abstract: The invention provides a catalytic, chemospecific and stereospecific method of oxidizing a wide variety of substrates without unwanted side reactions. Essentially, the method of the instant invention, under relatively mild reaction conditions, catalytically, stereospecifically and chemospecifically inserts oxygen into a hydrocarbon C—H bond. Oxidation (oxygen insertion) at a tertiary C—H bond to form an alcohol (and in some cases a hemiacetal) at the tertiary carbon is favored. The stereochemistry of an oxidized tertiary carbon is preserved. Ketones are formed by oxidizing a secondary C—H bond and ring-cleaved diones are formed by oxidizing cis tertiary CH bonds.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: March 27, 2007
    Assignee: Purdue Research Foundation
    Inventors: Philip Fuchs, Seongmin Lee