Spiro Patents (Class 549/330)
  • Patent number: 9856508
    Abstract: Chemiluminescent compositions, methods, assays and kits for oxidative enzymes are described. Further disclosed are dioxetane compounds of the form: where R can independently be any branched alkyl or cycloalkyl group which provides stabilization for the dioxetane or where both R groups together form a cycloalkyl or polycycloalkyl moiety spiro bound to the dioxetane ring, wherein each R group or the spiro bound moiety can be unsubstituted or substituted with one or more electron-withdrawing groups or electron donating groups, or groups providing preferential oxidative isozyme substrate recognition, and wherein R1 is an aryl group, or an alkyl group of 1-20 carbon atoms, which can be optionally substituted with 1 or more halogen atoms, and wherein T is an aryl or heteroaryl ring capable of emitting light upon enzyme activated decomposition of the dioxetane I. Kits, methods and assays are also disclosed that comprise the dioxetane compounds.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: January 2, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Rouh-Rong Juo, Brooks Edwards, Melissa Gee, Zhixian Wang, Kathleen Skaare
  • Patent number: 9695186
    Abstract: An alicyclic diepoxy compound represented by the following general formula (1): (in the general formula (1), R1 and R2 each independently represent one selected from the group consisting of a hydrogen atom, alkyl groups having 1 to 10 carbon atoms, and a fluorine atom, and n represents an integer of 2 to 5).
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: July 4, 2017
    Assignee: JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Daisuke Watanabe, Takaya Matsumoto
  • Patent number: 9518285
    Abstract: Chemiluminescent compositions, methods, assays and kits for oxidative enzymes are described. Further disclosed are dioxetane compounds of the form: where R can independently be any branched alkyl or cycloalkyl group which provides stabilization for the dioxetane or where both R groups together form a cycloalkyl or polycycloalkyl moiety spiro bound to the dioxetane ring, wherein each R group or the spiro bound moiety can be unsubstituted or substituted with one or more electron-withdrawing groups or electron donating groups, or groups providing preferential oxidative isozyme substrate recognition, and wherein R1 is an aryl group, or an alkyl group of 1-20 carbon atoms, which can be optionally substituted with 1 or more halogen atoms, and wherein T is an aryl or heteroaryl ring capable of emitting light upon enzyme activated decomposition of the dioxetane I. Kits, methods and assays are also disclosed that comprise the dioxetane compounds.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: December 13, 2016
  • Patent number: 9212120
    Abstract: Disclosed is a method for the synthesis of spiro[2.5]octane-5,7-dione useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed are novel intermediates used in the synthesis of this compound.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: December 15, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Torsten Busch, Sven Anklam, Joerg Jung, Markus Ostermeier
  • Patent number: 9139552
    Abstract: The present invention relates to indeno-fused naphthopyrans, and in particular indeno[2?,3?:3,4]naphtho[1,2-b]pyrans having certain groups bonded to the 3, 6, 7, 11, and 13 positions thereof. The indeno-fused naphthopyrans of the present invention have an ethylenically unsaturated group selected from (C1-C6 alkyl)acrylate and (C1-C6 alkyl)acrylamide, that is linked to the 11 position or 13 position thereof. The present invention also relates to photochromic articles and photochromic compositions containing such indeno-fused naphthopyrans.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: September 22, 2015
    Assignee: Transitions Optical, Inc.
    Inventors: Wenjing Xiao, Barry Van Gemert
  • Patent number: 8987477
    Abstract: The present invention relates to photochromic double-indeno-fused naphthopyrans of the general formula (I) and the use thereof in plastics of all kinds, particularly for ophthalmic purposes. The photochromic compounds according to the invention are characterized by two distinct absorption bands of the open form in the visible wavelength range, i.e. two conventional photochromic dyes, each having only one discrete absorption band, can be replaced with dye molecules of this type. The compounds according to the invention, moreover, have a very good lifetime with a very high performance.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: March 24, 2015
    Assignee: Rodenstock GmbH
    Inventors: Udo Weigand, Herbert Zinner, Yven Rohlfing
  • Patent number: 8975415
    Abstract: The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by ?-secretase activity, hydrolysis of a ?-secretase site of a ?-amyloid precursor protein, and/or ?-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: March 10, 2015
    Assignee: CoMentis, Inc.
    Inventors: Ryosuke Munakata, Makoto Inoue, Hiroaki Tominaga, Shingo Yamasaki, Yasuhiro Shina, Kiyohiro Samizu, Hisao Hamaguchi, Lin Hong
  • Patent number: 8916071
    Abstract: A chromene compound which has a sulfur-containing substituent represented by the following formula (2) at the 6-position and/or 7-position carbon atom of an indeno(2,1-f)naphtho(1,2-b)pyran structure and is excellent in photochromic properties and stability at a high temperature. In the formula (2), ring X is an aromatic hydrocarbon ring or aromatic heterocyclic ring, R3 and R4 are each independently an alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, amino group, heterocyclic group containing a ring member nitrogen atom and bonded to the ring X bonded thereto via the nitrogen atom, halogen atom, aryloxy group or aryl group, and “a” is an integer of 0 to 4.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: December 23, 2014
    Assignee: Tokuyama Corporation
    Inventors: Yasutomo Shimizu, Shinobu Izumi, Junji Takenaka, Junji Momoda
  • Patent number: 8901038
    Abstract: The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, and CKE have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides and/or fungicides. Moreover, the invention relates to selectively herbicidal compositions comprising, firstly, the biphenyl-substituted cyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to the boosting of the action of crop protection compositions comprising in particular biphenyl-substituted cyclic ketoenols through the addition of ammonium or phosphium salts and optionally penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as insecticides and/or nematicides and/or acaricides and/or fungicides and/or for preventing unwanted plant growth.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: December 2, 2014
    Assignee: Bayer CropScience AG
    Inventors: Reiner Fischer, Stefan Lehr, Isolde Häuser-Hahn, Christopher Hugh Rosinger, Chieko Ueno, Arnd Voerste, Elmar Gatzweiler, Ines Heinemann, Ulrich Görgens
  • Publication number: 20140332787
    Abstract: Disclosed are a compound for an organic optoelectronic device, an organic light emitting diode including the same, and a display device including the organic light emitting diode. The compound for an organic optoelectronic device represented by a combination of the following Chemical Formula 1 and Chemical Formula 2 provides an organic light emitting diode having life-span characteristics due to excellent electrochemical and thermal stability, and high luminous efficiency at a low driving voltage.
    Type: Application
    Filed: December 18, 2012
    Publication date: November 13, 2014
    Inventors: Jin-Seok Hong, Young-Kyoung Jo, Dong-Wan Ryu, Nam-Heon Lee, Han-Ill Lee, Sung-Hyun Jung, Mi-Young Chae, Dal-Ho Huh
  • Publication number: 20140330028
    Abstract: The present invention relates to photochromic double-indeno-fused naphthopyrans of the general formula (I) and the use thereof in plastics of all kinds, particularly for ophthalmic purposes. The photochromic compounds according to the invention are characterized by two distinct absorption bands of the open form in the visible wavelength range, i.e. two conventional photochromic dyes, each having only one discrete absorption band, can be replaced with dye molecules of this type. The compounds according to the invention, moreover, have a very good lifetime with a very high performance.
    Type: Application
    Filed: December 7, 2012
    Publication date: November 6, 2014
    Inventors: Udo Weigand, Herbert Zinner, Yven Rohlfing
  • Publication number: 20140225040
    Abstract: The present invention relates to compounds for use in electronic devices, preferably organic electroluminescent devices. The invention furthermore relates to processes for the preparation of these compounds and to electronic devices comprising these compounds, preferably in a function as matrix materials and/or as electron-transport materials.
    Type: Application
    Filed: July 3, 2012
    Publication date: August 14, 2014
    Applicant: Merck Patent GmbH Patents & Scientific Information
    Inventors: Amir Hossain Parham, Christof Pflumm, Anja Jatsch
  • Publication number: 20140225050
    Abstract: A chromene compound which has a sulfur-containing substituent represented by the following formula (2) at the 6-position and/or 7-position carbon atom of an indeno (2,1-f)naphtho(1,2-b)pyran structure and is excellent in photochromic properties and stability at a high temperature. (In the above formula, ring X is an aromatic hydrocarbon ring or aromatic heterocyclic ring, R3 and R4 are each independently an alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, amino group, heterocyclic group containing a ring member nitrogen atom and bonded to the ring X bonded thereto via the nitrogen atom, halogen atom, aryloxy group or aryl group, and “a” is an integer of 0 to 4.
    Type: Application
    Filed: September 21, 2012
    Publication date: August 14, 2014
    Applicant: TOKUYAMA CORPORATION
    Inventors: Yasutomo Shimizu, Shinobu Izumi, Junji Takenaka, Junji Momoda
  • Patent number: 8786181
    Abstract: The present invention relates to a blend comprising; a) at least one polymer or copolymer or a mixture of a plurality of polymers and/or copolymers which contain a main chain and a side chain, where at least one side chain contains a structural unit of the following formula (I), the symbols and indices used here are as defined below; b) at least one host molecule which has electron- or hole-transporting functionality, and c) at least one emitter molecule.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: July 22, 2014
    Assignees: Merck Patent GmbH, Fraunhofer-Gesellschaft Forschung E.V.
    Inventors: Thomas Eberle, Rémi Manouk Anémian, Manuel Thesen, Hartmut Krueger, Armin Wedel, Beatrice Salert, Stefanie Kreissl
  • Publication number: 20140197392
    Abstract: An organic light emitting element which realizes a high efficiency and long-life light emission is provided. An organic compound represented by the general formula [1] described in Claim 1 is provided. In the general formula [1], R1 to R3 are each independently selected from a hydrogen atom, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group. However, at least one of R1 to R3 represents the aryl group or the heterocyclic group. The aryl group represents a phenyl group, a naphthyl group, a phenanthrenyl group, a fluorenyl group, a triphenylenyl group, or a chrysenyl group. The heterocyclic group represents a dibenzofuranyl group or a dibenzothienyl group.
    Type: Application
    Filed: May 30, 2012
    Publication date: July 17, 2014
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Takayuki Horiuchi, Jun Kamatani, Kenichi Ikari, Akihito Saitoh
  • Patent number: 8778236
    Abstract: A novel photochromic compound which develops a color of a neutral tint and has high color optical density, high fading speed and excellent durability. The present invention is a chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as the basic skeleton in which a hetero ring having two hetero atoms including at least one sulfur atom is directly bonded to the 6-position and the 7-position of the indeno(2,1-f)naphtho(1,2-b)pyran structure via the hetero atom like the compound represented by the following formula (18).
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: July 15, 2014
    Assignee: Tokuyama Corporation
    Inventors: Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Toshiaki Takahashi, Mitsuyoshi Sando, Shinobu Izumi
  • Patent number: 8754207
    Abstract: The invention relates to processes for the preparation of compound of CCI-779 having the Formula (I), which is useful as an antineoplastic agent. The invention further relates to certain novel intermediates useful in the preparation of compound of CCI-779 and processes for their preparation. The invention also relates to pharmaceutical compositions that include the compound of CCI-779, prepared according to the processes disclosed herein.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: June 17, 2014
    Assignee: Cadila Healthcare Limited
    Inventors: Mayank Ghanshyambhai Dave, Bipin Pandey
  • Publication number: 20140154527
    Abstract: A chromene compound having a short fading half period, especially, a short fading half period even at a low temperature in a general-purpose polymer solid matrix. The chromene compound is represented by the following formula (1). wherein R1 is a hydroxyl group or the like, R2 and R3 are each an aryl group or the like, C* is a spiro carbon atom, a spiro ring A represented by the following formula is a saturated hydrocarbon ring having 4 to 12 ring member carbon atoms or the like, and at least one ring member carbon atom constituting the ring A is a group represented by the following formula (4), and X is a divalent group such as arylene group, wherein R7 and R8 are each a cycloalkyl group or the like.
    Type: Application
    Filed: June 19, 2012
    Publication date: June 5, 2014
    Applicant: TOKUYAMA CORPORATION
    Inventors: Shinobu Izumi, Kazuhiro Teranishi, Yusuke Daikoku, Mitsuyoshi Sando
  • Patent number: 8709308
    Abstract: The chromene compound is represented by the following formula (I), wherein R3 at the 11-position is a sulfur-containing substituent selected from the group consisting of thiol group, alkylthio group, alkoxyalkylthio group, haloalkylthio group, cycloalkylthio group, arylthio group, heteroarylthio group, sulfonyl group and sulfinyl group, R1 and R2 at the 6-position and the 7-position are a combination of an aryl group or a heteroaryl group and an electron donating group having a Hammett constant ?p of ?0.1 or less, or R1 and/or R2 is sulfur-containing substituent selected from thiol group, alkylthio group, alkoxyalkylthio group, haloalkylthio group, cycloalkylthio group, arylthio group and heteroarylthio group.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 29, 2014
    Assignee: Tokuyama Corporation
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Mitsuyoshi Sando, Shinobu Izumi
  • Patent number: 8691120
    Abstract: A photochromic chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as its basic skeleton, an aryl group or a heteroaryl group at the 6-position carbon atom of the structure and an electron donor group having a Hammett constant ?p of not more than ?0.1 at the 7-position carbon atom.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: April 8, 2014
    Assignee: Tokuyama Corporation
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Mitsuyoshi Sando, Kazuhiro Teranishi
  • Publication number: 20140034884
    Abstract: A chromene compound which develops a color of a neutral tint and has little initial coloration, high double peak characteristic and high color development sensitivity, rarely experiences the reduction of color optical density though it has high fading speed, is excellent in the durability of photochromic properties and can dissolve in a monomer composition which will become a substrate for optical articles in a high concentration, and a photochromic curable composition comprising the chromene compound and polymerizable monomers. The chromene compound is represented by the following formula (1).
    Type: Application
    Filed: January 26, 2012
    Publication date: February 6, 2014
    Applicant: TOKUYAMA CORPORATION
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Mitsuyoshi Sando, Shinobu Izumi
  • Publication number: 20140030529
    Abstract: A chromene compound which develops a color of a neutral tint and has high color optical density, high fading speed and excellent durability and a photochromic curable composition comprising the chromene compound and polymerizable monomers. The chromene compound is represented by the following formula (1). (wherein R1 is an aryl group or heteroaryl group, and R2 is a sulfur-containing substituent selected from the group consisting of thiol group, alkylthio group, alkoxyalkylthio group, haloalkylthio group, cycloalkylthio group, arylthio group and heteroarylthio group.
    Type: Application
    Filed: January 25, 2012
    Publication date: January 30, 2014
    Applicant: TOKUYAMA CORPORATION
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Kazuhiro Teranishi, Shinobu Izumi
  • Publication number: 20140027757
    Abstract: The present invention provides a novel stable organic compound and also provides an organic light-emitting device having a high luminous efficiency and a low driving voltage. The present invention relates to a spiro compound represented by the following Formula [1]: wherein, R1 to R5 are each independently selected from hydrogen atoms and alkyl groups having 1 to 4 carbon atoms and may be the same or different; and X is any of a sulfur atom, an oxygen atom, and a carbon atom, and when X is a carbon atom, the carbon atom may have one or two alkyl groups having 1 to 4 carbon atoms, and when the carbon atom has two alkyl groups having 1 to 4 carbon atoms, the two alkyl groups may be the same or different.
    Type: Application
    Filed: April 5, 2012
    Publication date: January 30, 2014
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Naoki Yamada, Taiki Watanabe, Kengo Kishino, Jun Kamatani
  • Patent number: 8617436
    Abstract: Remote marker systems are disclosed for marking a target using optical markers, including systems that allow a target to be marked using a remote optical marking device, as well as photochromic solutions and methods of their preparation.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: December 31, 2013
    Assignee: Bloomfield Science Museum Jerusalem
    Inventors: Amir Ben Shalom, Jacob Rosenberg
  • Publication number: 20130327995
    Abstract: A compound represented by Formula (I) or (II). wherein A is a single bond or a divalent residue of biphenyl, triphenyl, in each of which one or more hydrogen atoms attached in the carbon atoms may be replaced by a substituent other than hydrogen, wherein Z is any one selected from N, O, S, and SiR, Y is N—R, O, S, Si(R)2 where R is C1-20 alkyl or aryl, R1 and R2 are independently selected from hydrogen or C1-20 alkyl; X1 to X4 are independently selected from substituents other than spirobifluorenyl, A, B1 or B2 l, p and q are integers of from 0 to 4; m is an integer of from 0 to 3, wherein B1 and B2 are independently selected from hydrogen and a heterocyclic group; r is an integer of from 0 to 3; and X1 to X4, m, p, and q are as defined in Formula (I), with the proviso that B1 and B2 are not hydrogen simultaneously. The use of such compounds in OLEDs is also claimed.
    Type: Application
    Filed: October 7, 2011
    Publication date: December 12, 2013
    Applicant: SOLVAY SOCIETE ANONYME
    Inventors: Jonathan Maunoury, Enrico Orselli, Dominique Bascour
  • Publication number: 20130324741
    Abstract: Novel substituted spirobifluorene compounds useful as intermediates for materials in organic electronics devices
    Type: Application
    Filed: October 7, 2011
    Publication date: December 5, 2013
    Inventors: Dominique Bascour, Jean-Pierre Catinat
  • Patent number: 8574607
    Abstract: Compounds of the formula (I) useful as pesticides are disclosed, wherein the substituents are as defined in claim 1.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: November 5, 2013
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Jürgen Harry Schaetzer, Thomas Pitterna, Long Lu, Yaming Wu, Peter Renold, Francesca Perruccio, Jérome Yves Cassayre, Michel Mueglebach
  • Patent number: 8563714
    Abstract: The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds as ALX receptor and/or FPRL2 agonists for the treatment of inflammatory and obstructive airways diseases.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: October 22, 2013
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Daniel Bur, Olivier Corminboeuf, Sylvaine Cren, Corinna Grisostomi, Xavier Leroy, Sylvia Richard-Bildstein
  • Publication number: 20130135574
    Abstract: A liquid crystal compound of Formula (I) is provided. In Formula (I), A is benzene, naphthalene, pyridine, furan, thiophene or a single bond, D is benzene, naphthalene, pyridine, furan, thiophene or a single bond, R1 and R2 are C1-10 alkyl, C1-10 alkoxy, fluoro or trifluoro methyl, E is benzene, naphthalene, pyridine, furan, thiophene or a single bond, W is —CO—O—, —O—CO—, —O—, —CH2—CH2—, —CH?CH—, —CH2—O— or a single bond, Z is benzene, naphthalene, pyridine, furan, thiophene or a single bond, Y is hydrogen, methyl, ethyl or propyl, m is 0, 1 or 2, p is 0, 1 or 2, r is 0, 1 or 2, q is 0, 1 or 2, and n is 0, 1, 2 or 3. The invention also provides a liquid crystal display and photochromic material including the compound.
    Type: Application
    Filed: December 29, 2011
    Publication date: May 30, 2013
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yi-Rong WANG, Chih-Lung CHIN, Wan-Chi CHEN, Kung-Lung CHENG, Shih-Hsien LIU
  • Publication number: 20130105786
    Abstract: A novel and stable spiro(anthracene-9,9-fluoren)-10-one compound represented by general formula [1] is provided.
    Type: Application
    Filed: July 8, 2011
    Publication date: May 2, 2013
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Taiki Watanabe, Masashi Hashimoto, Jun Kamatani, Akihito Saitoh
  • Patent number: 8362170
    Abstract: Provided is a polymerizable compound represented by the following general formula (ca-1) or (cb-1): wherein the variables in the formulae are defined in the specification.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: January 29, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Shuji Hirano, Kaoru Iwato, Hiroshi Saegusa, Yusuke Iizuka
  • Patent number: 8252877
    Abstract: Provided is a polymerizable compound represented by the following general formula (ca-1) or (cb-1): wherein the variables in the formulae are defined in the specification.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: August 28, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Shuji Hirano, Kaoru Iwato, Hiroshi Saegusa, Yusuke Iizuka
  • Publication number: 20120170098
    Abstract: A photochromic chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as its basic skeleton, an aryl group or a heteroaryl group at the 6-position carbon atom of the structure and an electron donor group having a Hammett constant ?p of not more than ?0.1 at the 7-position carbon atom.
    Type: Application
    Filed: September 15, 2010
    Publication date: July 5, 2012
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Mitsuyoshi Sando, Kazuhiro Teranishi
  • Publication number: 20120161089
    Abstract: A chromene compound having a skeleton represented by the following formula (1) and exhibiting double peak characteristic: wherein Z is a group represented by anyone of the following formulas: (R1 is an electron donor group having a Hammett constant ?p of less than ?0.20, with the proviso that when there are a plurality of R1's, R1's may be the same or different, and R2 is a group having a Hammett constant ?p of ?0.
    Type: Application
    Filed: August 26, 2010
    Publication date: June 28, 2012
    Inventors: Toshiaki Takahashi, Junji Takenaka
  • Publication number: 20120165556
    Abstract: Provided is a benzo[b]naphtho[1,2-d]furan compound having a wide band gap which gives excellent color purity of blue. Further provided are a light-emitting element, a light-emitting device, and an electronic device each of which uses the benzo[b]naphtho[1,2-d]furan compound and is highly reliable. A benzo[b]naphtho[1,2-d]furan compound represented by a general formula (G1) is provided. In the general formula (G1), An represents an anthryl group represented by a general formula (An-1) or (An-2) below, ?1 and ?2 separately represent a substituted or unsubstituted phenylene group represented by any one of general formulae (?-1) to (?-3) below, and R1 to R9 separately represent either hydrogen or an alkyl group having 1 to 4 carbon atoms. Further, in the general formula (G1), n and m separately represent 0 or 1.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 28, 2012
    Inventors: Hiroki Suzuki, Satsohi Seo, Sachiko Kawakami, Tsunenori Suzuki
  • Publication number: 20120145974
    Abstract: A chromene compound which contains a skeleton represented by the following formula (1) and has high color optical density at the time of exposure, double peak characteristic, little initial coloration, a practical fading speed and durability. (wherein R1 is an electron donor group having a Hammett constant of less than 0, the ring including X is a hetero ring formed together with the 7-position and 8-position carbon atoms, and X is an oxygen atom, sulfur atom or group represented by ?NR2 directly bonded to the 7-position carbon atom.
    Type: Application
    Filed: June 22, 2010
    Publication date: June 14, 2012
    Inventors: Toshiaki Takahashi, Junji Takenaka, Kazuhiro Teranishi
  • Publication number: 20120121934
    Abstract: A photochromic chromene compound which develops a color of a neutral tint, has high color optical density, a high fading speed and high durability, and has an indeno(2,1-f)naphtho(1,2-b)pyran structure represented by the following formula as the basic skeleton, wherein a sulfur-containing substituent selected from thiol group, alkylthio group, alkoxyalkylthio group, haloalkylthio group, cycloalkylthio group, arylthio group and heteroarylthio group is bonded to the 6-position and/or 7-position carbon atom(s).
    Type: Application
    Filed: August 4, 2010
    Publication date: May 17, 2012
    Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Kazuhiro Teranishi
  • Patent number: 8163766
    Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: April 24, 2012
    Assignee: Amgen Inc.
    Inventors: Wenge Zhong, Stephen A. Hitchcock, Vinod F. Patel, Yuan Cheng, Michael Croghan, Randall W. Hungate, Daniel La, Patricia Lopez, Matthew K. Kaller, Holger Monenschein, Thomas Nguyen, Thomas Nixey, Lewis Pennington, Matthew Weiss, Ted Judd, Russell Graceffa, Qiufen Xue, Charles Kreiman, Brian K. Albrecht, Denise Lyn Andersen, Michael Bartberger, James Brown, Ryan Brown, Stuart C. Chaffee, Scott Harried, Craig Masse, Bryant Yang
  • Patent number: 8106221
    Abstract: The present invention is directed to aspartic protease inhibitors. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: January 31, 2012
    Assignee: Vitae Pharmaceuticals, Inc.
    Inventors: John J. Baldwin, Salvacion Cacatian, David A. Claremon, Lawrence W. Dillard, Patrick T. Flaherty, Alexey V. Ishchenko, Lanqi Jia, Gerard McGeehan, Robert D. Simpson, Suresh B. Singh, Colin M. Tice, Zhenrong Xu, Jing Yuan, Wei Zhao, Linghang Zhuang
  • Patent number: 8053576
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: November 8, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Patent number: 8007938
    Abstract: A non-aqueous electrolyte solution is provided that realizes a large capacity, exhibits high storage characteristics and cycle characteristics, and is capable of inhibiting gas generation.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: August 30, 2011
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Minoru Kotato, Asao Kominato
  • Publication number: 20110021613
    Abstract: Compounds obtainable from plants, e.g. of the genus Eucalyptus, or from microorganisms are shown to be useful as CNS activity modulators useful e.g. in the treatment of depression, for lifting mood and/or for increasing behavioural initiative and the like. This use and related aspects form embodiments of the invention. Also compounds as such are presented. The compounds useful are acylphloroglucine derivatives of the formula I, wherein the substituents are as defined in the description.
    Type: Application
    Filed: December 11, 2007
    Publication date: January 27, 2011
    Applicant: INTERMED DISCOVERY GMBH
    Inventors: Ernst Roemer, Torsten Grothe
  • Publication number: 20100310657
    Abstract: Provided is a pharmaceutical composition for the treatment and prevention of kidney diseases, containing (a) a therapeutically effective amount of a compound represented by Formulae 1 or 2 or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and (b) a pharmaceutically acceptable carrier, diluent or excipient or any combination thereof.
    Type: Application
    Filed: December 18, 2008
    Publication date: December 9, 2010
    Applicants: MAZENCE INC., KT & G CORPORATION
    Inventors: Taehwan Kwak, Myung-Gyu Park, Kyoung Hoon Jung
  • Publication number: 20100243971
    Abstract: The present invention relates to photochromic benzopyrans and to the use thereof in plastics of all kinds, especially for ophthalmic purposes. The inventive compounds are photochromic benzopyran compounds in which a polycyclic aromatic is joined to the 5 and 6 positions of a benzopyran, where the bond in the 6 position is direct and the bond in the 5 position is via a mono- or diatomic bridge.
    Type: Application
    Filed: November 25, 2008
    Publication date: September 30, 2010
    Inventors: Manfred Melzig, Yven Rohlfing, Udo Weigand
  • Patent number: 7799931
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: September 21, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Patent number: 7759044
    Abstract: A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: July 20, 2010
    Assignee: International Business Machines Corporation
    Inventors: Robert David Allen, Phillip Joe Brock, Richard Anthony DiPietro, Ratnam Sooriyakumaran, Hoa D. Truong
  • Patent number: 7592414
    Abstract: The invention provides low molecular weight or polymeric organic materials in which at least one hydrogen atom is replaced by a group of the formula (A) where R is alkyl group, alkoxyalkyl group, alkoxy group, thioalkoxy group, aryl group or alkenyl group, in each of which one or more hydrogen atoms may be replaced and one or more nonadjacent carbon atoms may be replaced. Z is —O—, —S—, —CO—, —COO—, —O—CO— or a bivalent group —(CR1R2)n— in which R1 and R2 are hydrogen, alkyl, alkoxy, alkoxyalkyl or thioalkoxy group, aryl or alkenyl, in each of which one or more hydrogen atoms may be replaced and one or more nonadjacent carbon atoms may be replaced, and n is an integer from 1 to 20. X is a bivalent group —(CR1R2)n— and, with the proviso that the number of these A groups is limited by the maximum number of available substitutable hydrogen atoms.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: September 22, 2009
    Assignee: Merck Patent GmbH
    Inventors: Klaus Meerholz, Michael Bayerl, Florian Bielefeldt, Thomas Braig, Markus Gross, David Müller, Oskar Nuyken, Hubert Spreitzer
  • Publication number: 20090131673
    Abstract: Disclosed are electroluminescent devices that comprise organic layers that contain dibenzofuran compounds. The compounds are suitable components of, for example, blue-emitting, durable, organo-electroluminescent layers. The electroluminescent devices may be employed for full color display panels in, for example, mobile phones, televisions and personal computer screens.
    Type: Application
    Filed: May 22, 2006
    Publication date: May 21, 2009
    Inventors: Junichi Tanabe, Hidetaka Oka, Hiroshi Yamamoto
  • Patent number: 7329634
    Abstract: The invention relates to novel 3-phenyl-substituted, 3-substituted 4-ketolactams and -lactones of the formula (I) in which Q, W, X, Y, A, B and G are as defined in the disclosure, to processes and intermediates for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: February 12, 2008
    Assignee: Bayer CropScience AG
    Inventors: Reiner Fischer, Stefan Lehr, Thomas Bretschneider, Mark Wilhelm Drewes, Dieter Feucht, Jörg Konze, Olga Malsam, Karl-Heinz Kuck, Guido Bojack, Thomas Auler, Martin Hills, Heinz Kehne
  • Patent number: 7323577
    Abstract: A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula: wherein R1 and R2 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula: WH wherein W is wherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R3 is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R4 is a hydrogen atom, an opt
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: January 29, 2008
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Hiroyuki Tawada, Makoto Yamashita, Yujiro Ono