Tricyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/349)
  • Patent number: 9035016
    Abstract: A polymer composition for solar cell and flexible electronics devices, where the polymer is a p-type conducting polymer. The p-type polymer comprises a benzothiadiazole acceptor and indeno-fluorene donor. Further, a solar cell and flexible electronic device article may be made from the polymer.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: May 19, 2015
    Assignee: Saudi Basic Industries Corporation
    Inventors: Dwight Seferos, Brandon Djukic, Ahmed I. Abdelrahman
  • Publication number: 20150051393
    Abstract: A pseudorotaxane, a rotaxane and a catenane are provided. The pseudorotaxane includes at least a macrocyclic host molecule, a guest molecule, and a metal ion. The host molecule contains at least a binding unit and an aromatic linking spacer. The guest molecule has at least a recognition unit. The metal ion is used to template the threading of the guest molecule through the macrocycle host molecule by coordinating to a binding pocket formed from the binding unit of the macrocycle and the recognition moiety of the guest molecule. Rotaxanes or catenanes can be synthesized from the pseudorotaxane complexes, with or without the metal template ion in their molecular structures.
    Type: Application
    Filed: October 28, 2014
    Publication date: February 19, 2015
    Inventors: Sheng-Hsien CHIU, You-Han LIN
  • Patent number: 8921412
    Abstract: Disclosed is a novel C-aryl ansa compound having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. Also provided are a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: December 30, 2014
    Assignee: Green Cross Corporation
    Inventors: Min Ju Kim, Suk Ho Lee, Soongyu Choi
  • Publication number: 20140350242
    Abstract: A pseudorotaxane, a rotaxane and a catenane are provided. The pseudorotaxane includes at least a macrocyclic host molecule, a guest molecule, and a metal ion. The host molecule contains at least a binding unit and an aromatic linking spacer. The guest molecule has at least a recognition unit. The metal ion is used to template the threading of the guest molecule through the macrocycle host molecule by coordinating to a binding pocket formed from the binding unit of the macrocycle and the recognition moiety of the guest molecule. Rotaxanes or catenanes can be synthesized from the pseudorotaxane complexes, with or without the metal template ion in their molecular structures.
    Type: Application
    Filed: May 24, 2013
    Publication date: November 27, 2014
    Inventors: Sheng-Hsien CHIU, You-Han LIN
  • Patent number: 8853263
    Abstract: The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: October 7, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Virginia L. Smith-Swintosky, David F. McComsey, Michael H. Parker, Allen B. Reitz, Bruce E. Maryanoff
  • Patent number: 8853348
    Abstract: A conjugated polymer containing dithienopyrrole-quinoxaline, the preparation method and uses thereof are provided. The structural formula of the polymer is general formula (I) as follows: wherein, x+y=1, 0<y?0.5, n is an integer and 1<n?100, R1 is selected from C1 to C20 alkyl group, and R2 and R3 are selected from —H, C1 to C20 alkyl group, C1 to C20 alkoxyl group, alkyl-containing phenyl group, alkyl-containing fluorenyl group, or alkyl-containing carbazyl group. The polymer can be used for polymer solar cells and the like.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: October 7, 2014
    Assignee: Ocean's King Lighting Science & Technology Co., Ltd.
    Inventors: Mingjie Zhou, Jie Huang, Erjian Xu
  • Patent number: 8846750
    Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: September 30, 2014
    Assignee: Korea Ocean Research and Development Institute
    Inventors: Joung Han Yim, Il Chan Kim, Doc Kyu Kim, Se Jong Han, Hyoung Seok Lee, Bhattarai Hari Datta, Jung Eun Kim, Tai Kyoung Kim, Hyun Cheol Oh, Dong-Gyu Jo, Cheolsoon Lee, Keun-Sik Kim, Pyung Cheon Lee, Mi Ra Park, Yu-Kyung Park, Sung Jin Kim, Pil-Sung Kang, Heeyong Park, Ha Ju Park
  • Patent number: 8809487
    Abstract: The present disclosure relates to a process for the synthesis of a conducting polymer comprising a benzothiadiazole acceptor and indeno-fluorene donor of formula [IV].
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: August 19, 2014
    Assignee: Saudi Basic Industries Corporation
    Inventors: Dwight Seferos, Brandon Djukic
  • Publication number: 20140221468
    Abstract: Store operated calcium channel modulating compounds, and methods for using the same, are provided. These compounds and methods find use in a variety of applications in which modulation of store operated calcium channels is desired.
    Type: Application
    Filed: December 9, 2011
    Publication date: August 7, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chan Young Park, Amir M. Sadaghiani, Ricardo Ei Dolmetsch
  • Publication number: 20140213642
    Abstract: Disclosed is a novel C-aryl ansa compound having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. Also provided are a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.
    Type: Application
    Filed: June 14, 2012
    Publication date: July 31, 2014
    Applicant: GREEN CROSS CORPORATION
    Inventors: Min Ju Kim, Suk Ho Lee, Soongyu Choi
  • Patent number: 8673890
    Abstract: The present invention is directed to novel 2,3-dihydro-1H-isoindol-1-imine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the thrombin PAR-1 receptor antagonists.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: March 18, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Kimberly White, Stephen C. Yabut, Hong Ye, Cailin Chen
  • Publication number: 20130261174
    Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.
    Type: Application
    Filed: July 1, 2011
    Publication date: October 3, 2013
    Applicant: KOREA OCEAN RESEARCH AND DEVELOPMENT INSTITUTE
    Inventors: Joung Han Yim, Il Chan Kim, Doc Kyu Kim, Se Jong Han, Hyoung Seok Lee, Bhattarai Hari Datta, Jung Eun Kim, Tai Kyoung Kim, Hyun Cheol Oh, Dong-Gyu Jo, Cheolsoon Lee, Keun-Sik Kim, Pyung Cheon Lee, Mi Ra Park, Yu-Kyung Park, Sung Jin Kim, Pil-Sung Kang, Heeyong Park, Ha Ju Park
  • Patent number: 8471064
    Abstract: The invention relates to novel copolymers comprising indenofluorene units and units of thiophene or its derivatives, to organic semiconductor (OSC) materials and organic electroluminescent materials comprising the copolymers, to the use of the copolymers and materials in electronic, electroluminescent or electrooptical devices, and to devices comprising the copolymers or materials.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: June 25, 2013
    Assignee: Merck Patent GmbH
    Inventors: Junyou Pan, Frank Meyer, Aurélie Ludemann, Arne Buesing
  • Patent number: 8343450
    Abstract: Methods and compositions to extract radionuclides such as various actinides and lanthanides from organic and/or aqueous solutions by utilizing extractant functionalized carbon nanotubes are disclosed. More particularly, phosphorous-containing (such as phosphine oxides, phosphoric acids or phosphates) organic extractants and other predesigned extractants (such as crown ethers, calncrown derivatives, malonamide and diglycolamide derivatives, polyethylene glycol derivatives, cobalt dicarbollide derivatives, and N-donating heterocyclic ligands) can be covalently and/or non-covalently employed on the surfaces and/or ends (tips) of carbon nanotubes for the purpose of removal radionuclides such as various actinides and lanthanides from organic and/or aqueous solutions. Extractant functionalized carbon nanotubes can be used for extracting radioactive nuclides from nuclear waste or spent nuclear fuel, which are produced and/or reprocessed from the nuclear power generation or other nuclear application.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: January 1, 2013
    Assignee: Chemnano Materials, Ltd.
    Inventor: Pingshan Wang
  • Publication number: 20120273725
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following formula: wherein: R1, R2 are independently aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; R3 and R4 are independently hydrogen, halogen, cyano, alkoxy, NHCOR7, NHSO2R7, COOR7, OCOR7, aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine with either R1 or R2 to form a carbocylic or heterocyclic ring; R5 and R6 are independently hydrogen, CH2, CH, alkyl or aryl either substituted or unsubstituted, COOR7, or combine with L to form a carbocyclic or heterocyclic ring; R7 is aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl or heterocyclic all either substituted or unsubstituted; L is the non-metallic elements required to form a carbocyclic or heterocyclic ring, or a single bond or a double bond; m is 1-3; n is 0-12.
    Type: Application
    Filed: April 26, 2012
    Publication date: November 1, 2012
    Applicants: Kent State University, Kent Displays Incorporated
    Inventors: Donald R. Diehl, Thomas Welter, Erica N. Montbach, J. William Doane, Nithya Venkataraman
  • Patent number: 8153827
    Abstract: The present disclosure provides isotopically substituted compounds of the formula (I): wherein T, U, V, W, X, Y, Z, R0, R3, R4, R5 and R6 are as defined in the detailed description. The method for detection and quantification using the same is also disclosed.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: April 10, 2012
    Assignee: Purdue Research Foundation
    Inventors: Vincent Jo Davisson, Shirshendu K. Deb, Giselle Marcelline Knudsen-Mooney, Meiguo Xin
  • Publication number: 20120021962
    Abstract: The present disclosure relates to the preparation of ketal compounds from glycerol and levulinic acid and esters, and uses thereof.
    Type: Application
    Filed: July 15, 2011
    Publication date: January 26, 2012
    Applicant: SEGETIS, INC.
    Inventor: Sergey SELIFONOV
  • Patent number: 8084490
    Abstract: The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: December 27, 2011
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: David F. McComsey, Michael H. Parker, Allen B. Reitz, Bruce E. Maryanoff
  • Patent number: 8048850
    Abstract: In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: November 1, 2011
    Assignee: University of Washington
    Inventors: Henry C. Lai, Tomikazu Sasaki, Narendra P. Singh
  • Publication number: 20110137025
    Abstract: The disclosure provides metal organic frameworks useful for sensing, gas sorption, microelectronics and switches.
    Type: Application
    Filed: June 5, 2009
    Publication date: June 9, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Omar M Yaghi, Qiaowei Li, Ognjen S Miljanic, Wenya Zhang, James Frasere Stoddart
  • Patent number: 7700596
    Abstract: 3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein Ra and Rb are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: April 20, 2010
    Assignee: Neurosearch A/S
    Inventors: Dan Peters, John Paul Redrobe, Elsebet Østergaard Nielsen
  • Patent number: 7692030
    Abstract: Compounds having an artemisinin-related endoperoxide moiety covalently coupled to a hydrazone moiety through a linker. Compositions and methods for treating cancer using the compounds.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: April 6, 2010
    Assignee: University of Washington
    Inventors: Tomikazu Sasaki, Henry Lai, Narendra P. Singh
  • Publication number: 20090093664
    Abstract: Methods and compositions to extract radionuclides such as various actinides and lanthanides from organic and/or aqueous solutions by utilizing extractant functionalized carbon nanotubes are disclosed. More particularly, phosphorous-containing (such as phosphine oxides, phosphoric acids or phosphates) organic extractants and other predesigned extractants (such as crown ethers, calncrown derivatives, malonamide and diglycolamide derivatives, polyethylene glycol derivatives, cobalt dicarbollite derivatives, and N-donating heterocyclic ligands) can be covalently and/or non-covalently employed on the surfaces and/or ends (tips) of carbon nanotubes for the purpose of removal radionuclides such as various actinides and lanthanides from organic and/or aqueous solutions. Extractant functionalized carbon nanotubes can be used for extracting radioactive nuclides from nuclear waste or spent nuclear fuel, which are produced and/or reprocessed from the nuclear power generation or other nuclear application.
    Type: Application
    Filed: October 8, 2008
    Publication date: April 9, 2009
    Applicant: CHEMNANO MATERIALS, LTD.
    Inventor: Pingshan Wang
  • Publication number: 20090030068
    Abstract: The invention relates to novel antitumor compounds of general formula as well as their corresponding pharmaceutically acceptable salts, derivatives, prodrugs and stereoisomers. These compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. These compounds have cytotoxic activity and can be used for the treatment of the cancer.
    Type: Application
    Filed: December 14, 2006
    Publication date: January 29, 2009
    Applicant: PHARMA MAR, S.A.
    Inventors: Ma Jesus Martin Lopez, Jose Fernando Reyes Benitez, Rogelio Fernandez Rodriguez, Andres Francesch Solloso, Maria del Carmen Cuevas Marchante, Laura Coello Molinero
  • Publication number: 20080300298
    Abstract: The present invention provides novel honokiol derivatives, as well as pharmaceutical compositions containing the honokiol derivatives. These compounds and pharmaceutical compositions can be used in the prevention and/or treatment of cancer. In particular, honokiol derivatives, pharmaceutical compositions comprising the derivatives, and methods for their use in the treatment of myeloma are provided.
    Type: Application
    Filed: February 23, 2006
    Publication date: December 4, 2008
    Inventors: Jack L. Arbiser, Frank Amblard
  • Publication number: 20080227851
    Abstract: Novel laulimalide analogs, methods for the treatment of proliferative disease and processes for the synthesis of laulimalide and novel laulimalide analogs are described.
    Type: Application
    Filed: March 12, 2008
    Publication date: September 18, 2008
    Inventor: PAUL A. WENDER
  • Publication number: 20080220285
    Abstract: The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer.
    Type: Application
    Filed: April 21, 2006
    Publication date: September 11, 2008
    Applicant: Merck Patent GmbH
    Inventors: Horst Vestweber, Holger Heil, Philipp Stoessel, Arne Buesing, Amir Hossain Parham, Rocco Fortte
  • Patent number: 7361727
    Abstract: A polymerization process to derive a thermal-stabilized poly(1,4-dioxan-2-one) and cyclic ester monomer copolymer using a coordination-insertion catalyst/initiator. 1,4-dioxan-2-one and cyclic ester monomer, each containing less than 100-ppm water and having an acid value less than 0.5 mg KOH/g, and preferably less than 0.2 mg KOH/g, are copolymerized. Preferably the cyclic ester monomer is ?-caprolactone and the reaction is in an extruder.
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: April 22, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Ramani Narayan, Jean-Marie Raquez, Sunder Balakrishnan, Philippe Dubois, Philippe Degee
  • Patent number: 7112685
    Abstract: This invention relates resiniferatoxin derivatives useful in a vanilloid receptor binding assay and methods for production thereof.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 26, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Mark E. McDonnell, Larry E. Weaner, Sui Po Zhang
  • Patent number: 7091338
    Abstract: A purification method is disclosed for a predetermined water-insoluble extractant present in a liquid phase composition that additionally contains one or more additional extractants, synthesis reaction starting materials, and reaction byproducts dissolved as solutes in an organic diluent. An ion-containing compound is admixed with the composition to form an extractant/ion complex in the organic diluent phase that has an affinity for a new phase that is greater than the affinity for the first-named phase. The predetermined extractant/ion complex is separated from the diluent by using the new phase affinity, and the extractant/ion complex is preferably although not necessarily recovered. The extractant/ion complex is separated into extractant and ion. The extractant is recovered. Exemplary extractants include polyethers, crown ethers, crown thioethers, calixarenes, polyamines, cryptands, porphyrins and the like.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: August 15, 2006
    Assignee: PG Research Foundation
    Inventors: Andrew H. Bond, Richard E. Barrans, Jr., E. Philip Horwitz
  • Patent number: 7022664
    Abstract: The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: April 4, 2006
    Assignee: Givaudan SA
    Inventor: Philip Kraft
  • Patent number: 6784292
    Abstract: The invention relates to a method for the preparation of compound of formula (1). The invention further relates to the previously unknown compounds of formulas (5 and 6) as intermediates in the production of benzodiazepines of formula (1).
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: August 31, 2004
    Assignee: Schering AG
    Inventors: Eric Winter, Matthias Schneider, Ulf Tilstam
  • Publication number: 20040106809
    Abstract: The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst, acylation of dihydroartemisinin in the presence of an acid catalyst, extraction of arteether from an aqueous reaction mixture using 1% ethyl acetate in n-hexane followed by workup and purification of the impure arteether to yield 80-86% (w/w) pure alpha, beta arteether.
    Type: Application
    Filed: December 2, 2002
    Publication date: June 3, 2004
    Inventors: Rajendra Singh Bhakuni, Amit Tewari, Tarun Singh, Suman P.S. Khanuja
  • Patent number: 6710074
    Abstract: An object of the present invention is to provide a novel compound having antimalarial acitivity and an antimalarial agent containing the novel compound as an active component. An antimalarial agent containing 12-hidroxy-2-(1-methoxy-carbonylethyl)-5-oxo-10,11,13-trioxatricyclo[7.2.0.01,6]tridecane represented by a following formula (II) as an active agent is prepared.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: March 23, 2004
    Assignee: Japan Science and Technology Corporation
    Inventors: Masataka Ihara, Kiyosei Takasu, Yusuke Wataya, Hye-Sook Kim
  • Patent number: 6677463
    Abstract: The present invention provides a single pot process for the preparation of artesunic acid from artemisinin involving reduction followed by esterification of the reduced product at room temperature.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: January 13, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Rajendra Singh Bhakuni, Atul Prakash Kahol, Tarun Singh, Suman Preet Singh Khanuja
  • Publication number: 20030181513
    Abstract: The present invention relates to an improved method for the preparation of Artemether. Artemether prepared from the process is useful for the treatment of uncomplicated, severe complicated and multi drug resistant malaria.
    Type: Application
    Filed: March 25, 2002
    Publication date: September 25, 2003
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Rajendra Singh Bhakuni, Tarun Singh, Atul Prakash Kahol, Amit Tewari, Sudeep Tandon, Suman Preet Singh Khanuja
  • Publication number: 20030181736
    Abstract: The invention relates to the preparation and use as catalysts of diphosphines of the formula (I) 1
    Type: Application
    Filed: April 7, 2003
    Publication date: September 25, 2003
    Inventors: Birgit Drieben-Holscher, Joachim Kralik, Inga Ritzkopf, Christian Steffens, Guido Giffels, Claus Dreisbach, Thomas Prinz
  • Publication number: 20030166581
    Abstract: The invention encompasses novel salts of topiramate, and pharmaceutically acceptable polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, or amorphous forms thereof, as well as pharmaceutical compositions and pharmaceutical unit dosage forms containing the same. In particular, the invention encompasses pharmaceutically acceptable salts of topiramate, including without limitation topiramate sodium, topiramate lithium, topiramate potassium, or polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, and amorphous forms thereof. The invention further encompasses novel co-crystals or complexes of topiramate, as well as pharmaceutical compositions comprising them. The invention also encompasses methods of treating or preventing a variety of diseases and conditions including, but not limited to, seizures, epileptic conditions, tremors, cerebral function disorders, obesity, neuropathic pain, affective disorders, tobacco cessation, migraines, and cluster headache.
    Type: Application
    Filed: November 18, 2002
    Publication date: September 4, 2003
    Inventors: Orn Almarsson, Julius Remenar, Matthew L. Peterson
  • Publication number: 20030096805
    Abstract: Methods and compositions of antidepressants and analogs thereof for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful for treating a localized pain.
    Type: Application
    Filed: April 4, 2002
    Publication date: May 22, 2003
    Inventors: Ging Kuo Wang, Peter Gerner, Donald K. Verrecchia
  • Publication number: 20030083365
    Abstract: The present invention of compounds of formula (I) 1
    Type: Application
    Filed: April 3, 2002
    Publication date: May 1, 2003
    Inventors: Piet Tom Bert Paul Wigerinck, Wim Gaston Verschueren, Marc Francis Josephine Schroven, Marcel Frans Leopold De Bruyn
  • Publication number: 20030078291
    Abstract: An object of the present invention is to provide a novel compound having antimalarial acitivity and an antimalarial agent containing the novel compound as an active component. An antimalarial agent containing 12-hidroxy-2-(1-methoxy-carbonylethyl)-5-oxo-10,11,13-trioxatricyclo[7.2.0.01,6]tridecane represented by a following formula (II) as an active agent is prepared.
    Type: Application
    Filed: August 30, 2002
    Publication date: April 24, 2003
    Inventors: Masataka Ihara, Kiyosei Takasu, Yusuke Wataya, Hye-Sook Kim
  • Publication number: 20030065021
    Abstract: The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient.
    Type: Application
    Filed: October 1, 2002
    Publication date: April 3, 2003
    Inventors: Shinya Yamashita, Jiro Takeo, Shuji Jinno, Yasuyo Kogure, Hiroyuki Onuki, Takaaki Okita, Junichiro Hata, Yasuhiro Fukuda, Naomi Ohtsuka
  • Patent number: 6521769
    Abstract: Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include chiral C1-C6 TunaPhos ligands. The ruthenium TunaPhos complex reduces ketones to the corresponding alcohols with 95-99.6% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation, hydride transfer, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, isomerization, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: February 18, 2003
    Assignee: The Penn State Research Foundation
    Inventor: Xumu Zhang
  • Publication number: 20020183513
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: April 22, 2002
    Publication date: December 5, 2002
    Inventors: Adelbert Grossmann, Wolfgang von der Saal, Tim Sattelkau, Ulrich Tibes
  • Patent number: 6403347
    Abstract: Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: June 11, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Russell B. Lingham, Ali Shafiee, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink, Fernando Pelaez, Ana M. Teran
  • Publication number: 20020055499
    Abstract: Compounds of the formula (I) are disclosed which are dual fibrinogen receptor and vitronectin receptor antagonists and are useful in the treatment of atherosclerosis, in the prevention of restenosis and in the prevention of tumor metastasis and tumor growth: 1
    Type: Application
    Filed: December 12, 2001
    Publication date: May 9, 2002
    Inventors: Dirk Heerding, James Martin Samanen
  • Publication number: 20020004522
    Abstract: Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits due to ischemia or hypoxia such as those that frequently occur as a consequence of cardiac surgery under cardiopulmonary bypass, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: April 2, 2001
    Publication date: January 10, 2002
    Applicant: NPS Pharmaceuticals, Inc.
    Inventors: Alan L. Mueller, Scott T. Moe
  • Patent number: 6025458
    Abstract: Disclosed are degradable materials including molded products, laminates, foams, nonwoven materials, adhesives, coatings and films, and particularly packaging films. The materials are made using polydioxaneone polymers comprising at least two different dioxaneone-based repeating units. Preferred polymers are polydioxanediones. First repeating units have less carbon atoms in constituent groups extending from the polymer backbone than second repeating units. Physical characteristics and degradation of the materials can be varied by varying the choice and/or relative proportions of first and second repeating units in the polydioxaneone polymers. Methods for preparing polydioxaneone polymers that can be used in the manufacture of the materials are also discussed, as are suitable monomers and methods for preparing such monomers.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: February 15, 2000
    Assignee: Chronopol, Inc.
    Inventors: Edward S. Lipinsky, Richard G. Sinclair, James D. Browning, Alex Cheung, Kevin H. Schilling, Dan W. Verser
  • Patent number: 5990321
    Abstract: Monoesters and macrocyclic diesters of 2,2,4-trimethyl-1,3-pentanediol and phthalic acid or a derivative thereof are described. Methods by which such monoesters and diesters may be prepared are also described. The mono- and diesters according to the invention are useful in the preparation of clear, hard thermoplastic polymers. The thermoplastic polymers are useful in coatings, inks, reinforced plastics and packaging materials.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: November 23, 1999
    Assignee: Eastman Chemical Company
    Inventor: Dale E. Van Sickle
  • Patent number: RE38117
    Abstract: Described herein are novel trioxane dimers of structure which possess antiproliferative and antitumor activities.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: May 6, 2003
    Assignees: Hauser, Inc., Johns Hopkins
    Inventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner