Exactly Four Oxygens In The Hetero Ring Patents (Class 549/353)
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Patent number: 8822707Abstract: Sulfonate leaving groups include a cation chelating moiety, e.g. a polyether or crown ether. The chelating moiety stabilizes the sulfonate leaving group by forming a complex with a cation of a cation-nucleophile combination. The stabilized leaving group is more easily displaced under many conditions than are standard arylsulfonate leaving groups such as the toxyl group. The chelating moiety also favors certain cations depending on the identity of the moiety thereby enhancing the reaction rate with nucleophilic salts containing the preferred cation. Use of the inventive leaving groups results in improved yields, decreased reaction times and improved product purity.Type: GrantFiled: November 14, 2005Date of Patent: September 2, 2014Assignee: Florida Atlantic UniversityInventor: Salvatore Lepore
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Patent number: 8049026Abstract: Ionic compounds which are liquids at room temperature are formed by the method of mixing a neutral organic ligand with the salt of a metal cation and its conjugate anion. The liquids are hydrophobic, conductive and stable and have uses as solvents and in electrochemical devices.Type: GrantFiled: January 10, 2008Date of Patent: November 1, 2011Assignee: UT-Battelle, LLCInventors: Sheng Dai, Huimin Luo
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Publication number: 20110118330Abstract: Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described.Type: ApplicationFiled: July 8, 2009Publication date: May 19, 2011Applicant: PURDUE RESEARCH FOUNDATIONInventor: Arun K. Ghosh
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Publication number: 20110070657Abstract: The present inventions include methods and compositions for detecting the presence of ions and measuring the level or concentration of ions in a sample by nuclear magnetic resonance (NMR) using magnetic particles. In particular, the inventions include the preparation and use of magnetic particles having synthetic ion chelators covalently bound to their surfaces. In the presence of target ions, the surface-modified magnetic particles form clusters, which can be monitored by NMR relaxation measurements. The relaxation times can then be used to detect specific ions and determine their concentration. The described methods, compositions, and devices are useful for a variety of applications including biomedical applications in diagnostics and imaging.Type: ApplicationFiled: August 18, 2008Publication date: March 24, 2011Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Lee Josephson, Sonia Taktak
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Patent number: 7906659Abstract: The present invention relates to certain carbocyclic and oxacarbocyclic fumaric acid oligomers and the use thereof for preparing a pharmaceutical preparation as well of pharmaceutical preparations containing these compounds.Type: GrantFiled: August 23, 2010Date of Patent: March 15, 2011Assignee: Biogen IDEC International GmbHInventors: Rajendra Kumar Joshi, Hans-Peter Strebel
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Patent number: 7423164Abstract: Ionic compounds which are liquids at room temperature are formed by the method of mixing a neutral organic liqand with the salt of a metal cation and its conjugate anion. The liquids are hydrophobic, conductive and stable and have uses as solvents and in electrochemical devices.Type: GrantFiled: December 31, 2003Date of Patent: September 9, 2008Assignee: UT-Battelle, LLCInventors: Sheng Dai, Huimin Luo
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Patent number: 6743564Abstract: Amine compounds having a cyano group are useful in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist.Type: GrantFiled: December 6, 2001Date of Patent: June 1, 2004Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Jun Hatakeyama, Tomohiro Kobayashi, Takeru Watanabe
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Patent number: 6323163Abstract: The present invention is a fluorine-containing compound having i) a perfluoropolyoxyalkyl or -alkylene chain having an average molecular weight of 800 or more and ii) a cyclic or non-cyclic polyether atomic group. Its use as a low-scattering lubricant or surface modifier (water repellent) brings about an improvement in sliding durability of magnetic recording media.Type: GrantFiled: June 17, 1999Date of Patent: November 27, 2001Assignee: Hitachi, Ltd.Inventors: Hiroshi Sasaki, Mitsuyoshi Shouji, Takayuki Nakakawaji, Tomoe Takamura, Mina Ishida, Yutaka Ito, Hiroyuki Matsumoto
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Patent number: 6130096Abstract: Rotaxanes and pseudorotaxanes, methods of making them, intermediates in their formation and methods of using them in sensors are provided based upon changes in color absorption upon cation contact.Type: GrantFiled: March 20, 1998Date of Patent: October 10, 2000Assignee: British Nuclear Fuels PLCInventors: Nigel Dennis Tinker, James Fraser Stoddart, Sayeedha Iqbal, Owen Allen Matthews
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Patent number: 5969074Abstract: A reaction of perfluoroolefins with bis(silyl) ethers to produce novel partially fluorinated and perfluorinated copolymers and macrocyclic compounds is disclosed.Type: GrantFiled: May 21, 1993Date of Patent: October 19, 1999Assignee: E. I. du Pont de Nemours and CompanyInventors: William Brown Farnham, Mario Joseph Nappa
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Patent number: 5721305Abstract: Glycerol, 2,2-dimethyl-1,3-dioxolane-4-methanol (Solketal), glycidol or glycerol carbonate is polymerized into preponderantly linear oligomers at 150.degree. C. to 350.degree. C. in the presence of anionic clay material, preferably hydrotalcite, as a catalyst.Type: GrantFiled: June 12, 1996Date of Patent: February 24, 1998Assignee: Unichema Chemie B.V.Inventors: Johan Jan W. Eshuis, Johannes Arie M. Laan, Glyn Roberts
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Patent number: 5657156Abstract: The invention relates to a polymeric optical amplifier doped with lanthanide ions, which are present in the amplifier in the form of a complex.The invention also relates to novel electrically neutral lanthanide complexes which can be applied with advantage in the above-described polymeric optical amplifiers. These complexes comprise host molecules which readily complex with the lanthanide and fully encapsulate it.Type: GrantFiled: March 15, 1996Date of Patent: August 12, 1997Assignee: Akzo Nobel nvInventors: Franciscus Cornelis Jacobus Maria van Veggel, Gustaaf Ronald Mohlmann
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Patent number: 5608058Abstract: A process of preparing a purified crown compound is disclosed which comprises the steps of (a) dissolving a crown compound and a salt in an organic solvent to form a solution of a complex salt of a crown compound; (b) filtering the solution to obtain a filtrate; (c) adding water to the filtrate to produce a precipitate; and (d) filtering out the produced precipitate.Type: GrantFiled: February 1, 1994Date of Patent: March 4, 1997Assignee: Konica CorporationInventors: Shinri Tanaka, Yasuhiko Kawashima
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Patent number: 5581398Abstract: The invention relates to a polymeric optical amplifier doped with lanthanide ions, which are present in the amplifier in the form of a complex. The invention also relates to novel electrically neutral lanthanide complexes which can be applied with advantage in the above-described polymeric optical amplifiers. These complexes comprise host molecules which readily complex with the lanthanide and fully encapsulate it.Type: GrantFiled: August 19, 1994Date of Patent: December 3, 1996Assignee: Akzo Nobel NVInventors: Franciscus C. J. M. van Veggel, Gustaaf R. Mohlmann
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Patent number: 5489699Abstract: Novel unsaturated peroxide compositions of Structure A,R--Q--X--R.sub.1 A[Where the R--Q-- grouping contains a polymerizable carbon-carbon double bond, --X-- is a direct bond or a connecting diradical and --R.sub.1 is a peroxide containing radical all as defined in the Summary of the Invention Section.], polymeric-peroxide compositions derived from them and their uses are disclosed.Type: GrantFiled: May 25, 1995Date of Patent: February 6, 1996Assignee: Elfatochem North America, Inc.Inventors: Jose Sanchez, Leonard H. Palys, Daryl L. Stein, John S. Yormick
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Patent number: 5457215Abstract: A reaction of perfluoroolefins with bis(silyl) ethers to produce novel partially fluorinated and perfluorinated copolymers and macrocyclic compounds is disclosed.Type: GrantFiled: July 5, 1994Date of Patent: October 10, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventors: William B. Farnham, Mario J. Nappa
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Patent number: 5314878Abstract: A composition for removing or inactivating harmful components including virus from blood or other extracellular liquids comprises a crownether compound substituted on a polysaccharide, preferably dextrane. The composition may be soluble in water, preferably for intraveneous application, or insoluble for extracorporeal application.Type: GrantFiled: December 13, 1991Date of Patent: May 24, 1994Assignee: A/S af 18. juni 1990Inventors: Henry M. Christensen, Hans B. Andreasen
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Patent number: 5274129Abstract: Novel derivatives of hydroxamic acid chelating agents for the chelation of f-block elements, yttrium and scandium and methods for the extraction of such elements.Type: GrantFiled: June 12, 1991Date of Patent: December 28, 1993Assignee: Idaho Research Foundation, Inc.Inventors: Nicholas R. Natale, Chien M. Wai, Sadik Elshani
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Patent number: 5254699Abstract: Provided are novel cyclic perfluoroethers which are thermally and chemical stable fluids. They are prepared by photo decarbonylation of cyclic perfluoroketones.Type: GrantFiled: April 16, 1992Date of Patent: October 19, 1993Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Hiroshi Inomata, Yasuo Tarumi, Noriyuki Koike, Shuzi Suganuma
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Patent number: 5210216Abstract: Calixarene and oxacalixarene derivatives of the formula IV: ##STR1## wherein m'+m"=0-8n=0-8m'.gtoreq.1/2(m'+m")3.ltoreq.m'+m"+n.ltoreq.8if n=0, m'+m".gtoreq.4R.sup.3 is H, halogen, or hydrocarbyl, aryl, hydrocarbylaryl or a substituted derivative thereof and R.sup.3 may be the same or different on each aryl group;R.sup.15 is H or hydrocarbyl, aryl, hydrocarbylaryl or a substituted derivative thereof;X is selected from ##STR2## wherein R.sup.7 and R.sup.8 which may be the same or different are H or hydrocarbyl (including a cycloaliphatic ring formed by R.sup.7 and R.sup.8 together), aryl, hydrocarbylaryl or a substituted derivative thereof; R.sup.9 is --OH, --NH.sub.2, --NHC(O)NH.sub.2 or --NHAr, wherein Ar is aryl or a substituted derivative thereof,n' is 0 or 1.Use of the compounds for sequestration of metals is also described.Type: GrantFiled: December 10, 1990Date of Patent: May 11, 1993Assignee: Loctite (Ireland) LimitedInventors: Stephen J. Harris, John Guthrie, Maureen MacManus, Ciaran McArdle, Michael A. McKervey
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Patent number: 5210233Abstract: Novel hydroxy containing fluorovinyl ethers, polymers of hydroxy containing fluorovinyl ethers, novel cyclic ethers, copolymers of selected hydroxy containing fluorovinyl ethers, a process for reducing ester containing fluorovinyl compounds to the corresponding alcohol with borohydrides, and a process for polymerizing hydroxy containing fluorovinyl ethers are disclosed.Type: GrantFiled: April 2, 1992Date of Patent: May 11, 1993Assignee: E. I. Du Pont de Nemours and CompanyInventors: William B. Farnham, Ming-Hong Hung
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Patent number: 5177221Abstract: The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic hemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;m is 1 to about 3;n is 0 to about 3;A is an aliphatic or aromatic subunit, e.g.Type: GrantFiled: August 8, 1990Date of Patent: January 5, 1993Assignees: Miles Inc., The Regents of the University of CaliforniaInventors: Donald J. Cram, Eddy Chapoteau, Bronislaw P. Czech, Carl R. Gebauer, Roger C. Helgeson, Anand Kumar, Koon-Wah Leong
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Patent number: 5133934Abstract: Compositions and test articles comprisng ionophore of an optically active isomer of bis(12-crown-4-methyl)dialkyl malonate, wherein alkyl group is methyl and the second alkyl group has 4 to 20 carbon atoms, with a reporter substance incorporated in a hydrophobic carrier are disclosed.Type: GrantFiled: February 22, 1991Date of Patent: July 28, 1992Assignee: Miles Inc.Inventors: James B. Denton, Kin-Fai Yip
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Patent number: 5132436Abstract: Intermediate compounds for the preparation of useful 14-crown-4-ether derivatives are presented. The intermediates have the structure: ##STR1## wherein R represents CH.sub.3, n-C.sub.12 H.sub.25 and CH.sub.2 C.sub.6 H.sub.5 ; and R.sub.2 represents CH.sub.3, and n-C.sub.7 H.sub.15.Type: GrantFiled: May 28, 1991Date of Patent: July 21, 1992Assignee: Eastman Kodak CompanyInventors: Ronald H. Engebrecht, Thomas R. Welter
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Patent number: 5082955Abstract: A method for separating the isomers of a crown ether compound and making it possible to recover in particular the pure cis-syn-cis isomer from DCH 18C6 includes:a) dissolving in an organic solvent a mixture of the isomers of said crown compound including the cis-anti-cis isomer and the cis-syn-cis isomer,b) adding uranyl nitrate to the solution obtained in stage a) in sufficient quantities so that virtually all of the isomers, except the cis-syn-cis isomer, are precipitated in the form of complexes with the uranyl nitrate,c) separating the formed precipitate,d) recovering the cis-syn-cis isomer from the solution, ande) recovering the cis-anti-cis isomer from the precipitate.Type: GrantFiled: December 11, 1990Date of Patent: January 21, 1992Assignee: Cogema-Compagnie Generale Des Matieres NucleariresInventors: Marc Lemaire, Alain Guy, Jacques Foos, Vincent Guyon, Rodolphe Chomel
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Patent number: 5047563Abstract: The synthesis and use of optically active isomers of bis(12-crown-4-methyl) dialkylmalonates as sodium specific ionophores is described. The synthesis of optically active isomers of hydroxymethyl 12-crown-4 useful in synthesizing ionophores is also described.Type: GrantFiled: September 10, 1987Date of Patent: September 10, 1991Assignee: Miles Inc.Inventors: James B. Denton, Kin-Fai Yip
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Patent number: 4985546Abstract: A substituted colorant which may be copolymerized with a condensation polymer to provide a covalently bound, nonextractable coloring, having the formula ##STR1## wherein R and R.sub.1 are independently selected from hydrogen or lower alkyl; R.sub.4 is selected from hydrogen or lower alkyl; x is 0 or 1; N and M are each integers of from 1 to about 100 and the sum of N and M is from 3 to about 100. The hydroxyl groups are protected by formation of a ring structure during alkoxylation and amination of the substituent.Type: GrantFiled: June 19, 1989Date of Patent: January 15, 1991Assignee: Milliken Research CorporationInventors: John W. Miley, John W. Rekers
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Patent number: 4977281Abstract: Primary amino polyoxyalkylene 1,3-dioxane or 1,3-dioxolane compounds are provided of the formula: ##STR1## wherein R and R.sub.1 are independently selected from hydrogen or a lower alkyl group; R.sub.2 and R.sub.3 are independently selected from hydrogen, phenyl or lower alkyl groups; R.sub.4 is selected from hydrogen or a lower alkyl group; x is 0 or 1; N and M are each integers of from 1 to about 100 and the sum of N an M is from 2 to about 100; also disclosed are polyoxyalkylene amino alcohol compounds which may be derived from the compounds of Formula I above having the formula: ##STR2## wherein R, R.sub.1, R.sub.4, x, N and M all have the values given above. Also provided is a process for preparing a primary amino polyoxyalkylene 1,3-dioxane or 1,3-dioxolane.Type: GrantFiled: December 21, 1987Date of Patent: December 11, 1990Assignee: Milliken Research CorporationInventors: John W. Miley, John W. Rekers
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Patent number: 4900845Abstract: New C-substituted crown ethers such as ##STR1## are made by reacting a 1,2-diol (chain length m+4) with ClCH.sub.2 --(CH.sub.2 --O--CH.sub.2 --).sub.n+1 CH.sub.2 Cl.These compounds have a stronger affinity for secondary amines than for tertiary amines and therefore may be used to separate mixtures, especially when attached to polysiloxane backbones or substrates via their unsaturated bond.Type: GrantFiled: January 25, 1988Date of Patent: February 13, 1990Assignee: National Research Development CorporationInventors: Brian J. Brisdon, Richard England, Sera S. Abed-Ali
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Patent number: 4859747Abstract: The direct fluorination of ethers in the presence of hydrogen fluoride (HF) scavengers such as sodium fluoride and potassium fluoride is disclosed. Ethers (liquid or solid) are either mixed with the HF scavenger, coated onto the HF scavenger or placed separately with the HF scavenger into a fluorination reactor and fluorinated by exposure to elemental fluorine. The HF scavenger permits use of more severe fluorination conditions than would be possible in the absence of the scavenger, i.e. higher initial fluorine, less gradual increases in fluorine gas concentrations and greater fluorine gas flow rates.Type: GrantFiled: May 24, 1988Date of Patent: August 22, 1989Assignee: Exfluor Research CorporationInventors: Thomas R. Bierschenk, Timothy J. Juhlke, Richard J. Lagow
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Patent number: 4824863Abstract: New polyether antibiotic A80438, its acyl and alkyl ester, alkyl ether and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Method of making A80438 by culture of Streptomyces bobili NRRL 15971 and synergistic compositions comprising (1) and A80438 compound and (2) nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds or metichlorpindol are also provided.Type: GrantFiled: May 28, 1985Date of Patent: April 25, 1989Assignee: Eli Lilly and CompanyInventors: Robert L. Hamill, Walter M. Nakatsukasa, Raymond C. Yao
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Patent number: 4570004Abstract: This specification discloses novel perfluorinated crown ethers which are believed useful as oxygen carriers and in the construction of various biomedical products.Type: GrantFiled: April 6, 1984Date of Patent: February 11, 1986Assignee: The Board of Regents, University of Texas SystemInventors: Richard J. Lagow, Wen-Huey Lin
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Patent number: 4562272Abstract: The invention relates to a process for preparing cyclic polyethers from cyclic alkylene carbonates in the presence of a solvent, wherein the process is carried out in the presence of a solvent selected from the group containing a carbonyl moiety, nitrile moiety or mixture thereof. In addition, ionic catalysts may be employed to increase the selectivity to cyclic polyether.Type: GrantFiled: March 27, 1981Date of Patent: December 31, 1985Assignee: Union Carbide CorporationInventors: Arnold M. Harrison, Leonard Kaplan
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Patent number: 4504368Abstract: Ion-selective compositions which comprise an ionophore, a compound capable of solvating the ionophore and a supporting matrix are disclosed. The ionophores useful in these compositions are certain crown ethers. These ion-selective compositions are particularly useful in ion-selective membranes and electrodes which are capable of selectively transporting a first ion in preference to a second ion. Such compositions, membranes and electrodes are useful for potentiometric measurement of alkali metal ions, e.g. lithium, sodium and potassium, in aqueous solutions, e.g. biological fluids. Dry-operative electrodes using these ion-selective compositions as membranes are also disclosed.Type: GrantFiled: July 18, 1983Date of Patent: March 12, 1985Assignee: Eastman Kodak CompanyInventors: Mary H. Delton, Daniel S. Daniel
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Patent number: 4474963Abstract: This invention relates to novel crown ether compositions which have been given the cognomen "lariat ethers". They have been designed with one or more arms bearing neutral donor groups capable of interacting with a complexed metal ion and thereby affording enhanced cation binding compared to simple crown ethers. Evidence of enhanced cation binding has been obtained and the compounds have also shown utility as phase transfer catalysts.Type: GrantFiled: November 8, 1982Date of Patent: October 2, 1984Assignee: W. R. Grace & Co.Inventor: George W. Gokel
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Patent number: 4435582Abstract: This invention deals with a process for the preparation of macrocyclic polyethers of the general formula: ##STR1## wherein x is 1-9; k is 0 or 1 and each R, which may be the same or different, represents a hydrogen atom or a lower alkyl or aryl group, or two R bonded to two adjacent carbon atoms form together with these carbon atoms a cyclic hydrocarbyl configuration, by reacting a compound of the general formula: ##STR2## with a sulphonyl halide in the presence of a base and a halogen-containing solvent, preferably chlorobenzene. The process is of special interest for the manufacture of 18-crown-6.Type: GrantFiled: April 9, 1981Date of Patent: March 6, 1984Assignee: Shell Oil CompanyInventors: Wilhelmus J. Krijnen, Paulus A. M. Grotenhuis
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Patent number: 4423238Abstract: A method of purifying trioxane and other acetals by contacting them with an alkali metal and a phase transfer catalyst is described. Trioxane so purified is capable of being polymerized to high molecular weight.Type: GrantFiled: June 17, 1982Date of Patent: December 27, 1983Assignee: Conoco Inc.Inventor: Jeff T. Fenton
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Patent number: 4398912Abstract: Cyclical polyethers having amphiphile groups are derived from the tetramer of epichlorhydrin. These are useful in the solubiliization of various products.Type: GrantFiled: July 30, 1981Date of Patent: August 16, 1983Assignee: L'OrealInventors: Guy Vanlerberghe, Henry Sebag
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Patent number: 4392978Abstract: A method and reagent for the selective nitration of aromatic hydrocarbons which comprises contacting a complex of at least a catalytic amount of a polyether with a nitronium containing substance, e.g., NO.sub.2 BF.sub.4 with an aromatic hydrocarbon, e.g., toluene with at least one replaceable hydrogen. Nitration of toluene with these complexes at ambient temperature resulted in a reduction in meta substitution. In competitive studies, soluble crown ether complexes of NO.sub.2 BF.sub.4 in CH.sub.2 Cl.sub.2 nitrated toluene 45-59 times faster than they nitrated benzene.Type: GrantFiled: December 26, 1979Date of Patent: July 12, 1983Assignee: Allied CorporationInventors: Ronald L. Elsenbaumer, Edel Wasserman
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Patent number: 4374974Abstract: There are provided linear aromatic polyformal compositions and cyclic polyformals. A method is also provided for making linear aromatic polyformals having reduced aromatic cyclic polyformal content to provide transparent films having improved Notched Izod Impact. The cyclic aromatic polyformals can be used as intermediates for making solvent resistant organic wire coating formulations.Type: GrantFiled: November 6, 1978Date of Patent: February 22, 1983Assignee: General Electric CompanyInventor: Allan S. Hay
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Patent number: 4328168Abstract: This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yield. For the process an alkylating agent and activated methylene compound are reacted in the presence of a cyclic polyether compound and alkali metal compound. Water can also be present and/or the reaction may be carried out in an inert organic diluent.Type: GrantFiled: October 27, 1980Date of Patent: May 4, 1982Assignee: Emery Industries, Inc.Inventor: Richard G. Fayter, Jr.