Chalcogen Or -c(=x), Wherein X Is Chalcogen, Bonded Directly To The Hetero Ring Patents (Class 549/372)
  • Patent number: 10196580
    Abstract: The disclosed technology relates to a lubricating composition additives that prevent or reduce seals degradation, especially in the presence of basic amine compounds which impart basicity (measured as total base number or TBN) to the lubricating composition. The lubricating composition contains (a) an oil of lubricating viscosity, (b) a basic amine compound, and (c) a 1,3-dioxane-4,6-dione compound.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: February 5, 2019
    Assignee: The Lubrizol Corporation
    Inventors: Yanshi Zhang, Jason J. Hanthorn, Ewan E. Delbridge
  • Publication number: 20150148543
    Abstract: The invention features methods and compositions for the synthesis of multimerizing agents.
    Type: Application
    Filed: January 28, 2015
    Publication date: May 28, 2015
    Inventors: Feng Li, Yihan Wang
  • Patent number: 9024044
    Abstract: Compounds represented by the following formula (I), are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: May 5, 2015
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takahiro Koshiba, Munetaka Tokumasu, Taisuke Ichimaru, Koji Ohsumi, Tadakiyo Nakagawa, Tatsuhiro Yamada, Kayo Matsumoto, Tamotsu Suzuki
  • Patent number: 9024028
    Abstract: The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: May 5, 2015
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Feng Li, Yihan Wang
  • Patent number: 8933251
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: January 13, 2015
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Satoshi Shinachi, Takeshi Kinsho, Koji Hasegawa, Yuji Harada, Jun Hatakeyama, Kazunori Maeda, Tomohiro Kobayashi
  • Patent number: 8901165
    Abstract: Described are alkoxylated glycerol acetals according to Formulas (Ia) and (Ib) wherein R1 represents a linear or branched, saturated or unsaturated and optionally substituted hydrocarbyl residue comprising 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, a benzyl or furfuryl radical, R2 is selected from hydrogen, an alkyl, alkenyl or hydroxyalkyl group having 6 to 22 carbon atoms or an acyl group having 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, AO represents an ethylene oxide, a propylene oxide, a butylene oxide unit, or their mixtures, and n is an integer of about 1 to about 100.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: December 2, 2014
    Assignee: Cognis IP Management GmbH
    Inventors: Ingo Fleute-Schlachter, Sandra Mack, Peter Kempers, Ulrich Schörken, Eckhard Paetzold, Udo Kragl
  • Publication number: 20140350269
    Abstract: It refers to a new group of acetal monoesters and diesters which have in its structure the ester function and cyclic ethers that give these products excellent properties as solvency, plasticity in polymers, solubility in polar and nonpolar means, spreadability, wetting, low volatility, non-toxicity and biodegradability. These properties make these products excellent candidates as solvents in formulations of pesticides, agricultural herbicides, for the paint and leather industry in domestic or industrial hygiene formulations; as plasticizers for polymers such as polyvinyl chloride, nitrocellulose, cellulose, acrylics, polyvinyl vinyl and its copolymers; as lubricants in industrial formulations, textile industry; as emollients agents which donate oiliness for the cosmetic industry; as wetting agents that are commonly used, and as biodiesel additives to reduce the freezing point and to improve its combustion.
    Type: Application
    Filed: April 28, 2014
    Publication date: November 27, 2014
    Applicant: GLYCEROSOLUTION QUÍMICA LTDA.
    Inventor: Marcelo EIJI BORGES SATO
  • Publication number: 20140308614
    Abstract: A negative pattern is formed by applying a resist composition onto a substrate, prebaking, exposing to high-energy radiation, PEB, and developing the exposed resist film in an organic solvent developer to dissolve the unexposed region of resist film. The resist composition is based on a polymer comprising recurring units (a1) of formula (1) wherein R1 is H or CH3, R2 and R3 are H, F or a monovalent hydrocarbon group, R4 is H or a monovalent hydrocarbon group, R5 and R6 are a monovalent hydrocarbon group, X1 is a divalent hydrocarbon group, and k1=0 or 1. A fine hole or trench pattern can be formed therefrom.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 16, 2014
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Koji Hasegawa, Masayoshi Sagehashi, Tomohiro Kobayashi, Kazuhiro Katayama
  • Publication number: 20140303241
    Abstract: The present invention provides a series of derivatives of stilbenoid which are useful as new inhibitory agents against head and neck squamous cell carcinoma (HNSCC) and hepatoma.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 9, 2014
    Applicant: AnnCare Bio-Tech Center Inc.
    Inventors: Sheng-Chu Kuo, Jai-Sing Yang, Min-Tsang Hsieh, Tian-Shung Wu, Kuo-Hsiung Lee, Huei-Wen Chen, Li-Jiau Huang, Hsin-Yi Hung, Tzong-Der Way, Ling-Chu Chang, Hui-Yi Lin, Yung-Yi Cheng, Chin-Yu Liu
  • Publication number: 20140235446
    Abstract: The compounds of the formula (I) in which L represents a radical of the formula and A1, B1 and A2 and B2 are as defined in Claim 1, are suitable as herbicides for the control of harmful plants or as plant growth regulators. The compounds can be prepared by the process of Claim 12.
    Type: Application
    Filed: July 11, 2012
    Publication date: August 21, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Marc Mosrin, Harald Jakobi, Alfred Angermann, Elmar Gatzweiler, Isolde Häuser-Hahn, Ines Heinemann, Christopher Hugh Rosinger, Stefan Lehr, Stefan Schnatterer
  • Publication number: 20140171649
    Abstract: The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.
    Type: Application
    Filed: January 26, 2012
    Publication date: June 19, 2014
    Applicant: ARIAD PHARMACEUTICALS, INC.
    Inventors: Feng Li, Yihan Wang
  • Patent number: 8742139
    Abstract: Phenyliodonium ylide derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are shown for use as precursors in aromatic nucleophilic substitution reactions. The iodonium ylide group is substituted by nucleophiles such as halide ions to provide the corresponding haloaryl derivatives. No-carrier-added [F-18]fluoride ion exclusively substitutes the iodonium ylide moiety in these derivatives and provides high specific activity F-18 labeled fluoro derivatives. Protected L-dopa-6-iodonium ylide derivative have been synthesized as a precursors for the preparation of no-carrier-added 6-[F-18]fluoro-L-dopa. The iodonium ylide group in this L-dopa.derivative is nucleophilically substituted by no-carrier-added [F-18]fluoride ion to provide a [F-18]fluoro intermediates which upon acid hydrolysis yielded 6-[F-18]fluoro-L-dopa.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: June 3, 2014
    Assignee: The Regents of The University of California
    Inventors: Nagichettiar Satyamurthy, Jorge R. Barrio
  • Publication number: 20140087978
    Abstract: A method of converting an inactive biocide into an active biocide comprises: contacting the inactive biocide with an activating agent, wherein the activating agent is capable of chemically reacting with the inactive biocide; and causing or allowing a chemical reaction to take place between the inactive biocide and the activating agent, wherein the chemical reaction produces the active biocide. The methods can also include deactivating the active biocide via a chemical reaction between the active biocide and a deactivating agent.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 27, 2014
    Applicant: HALLIBURTON ENERGY SERVICES, INC
    Inventor: Jay P. DEVILLE
  • Publication number: 20130309184
    Abstract: The invention relates to specific 1,3-dioxan-5-one compounds, to a process for the preparation thereof, and to the use thereof as dyes or as fluorescent emitters for organic electroluminescent devices (OLEDs) or for organic light-emitting electrochemical cells (OLECs), and to corresponding electronic devices.
    Type: Application
    Filed: January 16, 2012
    Publication date: November 21, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Thomas Rudolph, Philipp Buehle, Ralf Rosskopf
  • Publication number: 20130303466
    Abstract: Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
    Type: Application
    Filed: October 18, 2011
    Publication date: November 14, 2013
    Applicant: ELCELYX THERAPEUTICS, INC.
    Inventors: Martin R. Brown, Christopher R.G. Jones, Nigel R.A. Beeley, Alain D. Baron
  • Publication number: 20130231491
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Application
    Filed: March 20, 2013
    Publication date: September 5, 2013
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Shin-Etsu Chemical Co., Ltd.
  • Patent number: 8461290
    Abstract: This invention relates to the synthesis of polycarbonates prepared from carbonate monomers derived from the biomass in the presence of a system comprising an organometallic transfer agent and alcohol. It also relates to the polymers resulting from these cyclic compounds.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: June 11, 2013
    Assignees: Total Petrochemicals Research Feluy, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jean-François Carpentier, Sophie Guillaume, Marion Helou, Yann Sarazin, Olivier Miserque
  • Patent number: 8455668
    Abstract: A method for preparing hydroxymethylfurfural, which includes: a) mixing and dissolving triose or its derivatives and solvent 1 to obtain the first reaction mixture; b) reacting the obtained first reaction mixture with Alkaline Catalyst 1 to condense into hexose; c) mixing and dissolving the resulting hexose and solvent 2 to obtain the second reaction mixture; d) adding acid catalyst 2 to the second reaction mixture, then heating the second reaction mixture at 80˜280° C. to form the third reaction mixture including hydroxymethylfurfural; e) obtaining the hydroxymethylfurfural separating by separating from the third mixture. The method is a new synthetic way for preparing 4-hydroxymethylfurfural and 5-hydroxymethylfurfural.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: June 4, 2013
    Assignee: University of Science and Technology of China
    Inventors: Yao Fu, Jin Deng, Qingxiang Guo, Jing Zhao, Lei Liu
  • Publication number: 20120323005
    Abstract: The present invention relates to an improved process for the preparation of amide intermediates useful in the preparation of cholesterol reducing agents.
    Type: Application
    Filed: January 17, 2011
    Publication date: December 20, 2012
    Inventors: Manne Satyanarayana Reddy, Srinivasan Thirumalai Rajan, Maramreddy Sahadeva Reddy
  • Publication number: 20120232018
    Abstract: A cyclic carbonate monomer has the formula (2): wherein i) t and t? are integers independently having a value from 0 to 6 wherein t? and t cannot both be zero, ii) each Q1 is a monovalent radical independently selected from the group consisting of hydrogen, halides, alkyl groups comprising 1 to 30 carbons, and aryl groups comprising 6 to 30 carbon atoms, iii) L? is a divalent linking group comprising one or more carbons, and iv) S? is a steroidal group.
    Type: Application
    Filed: August 23, 2011
    Publication date: September 13, 2012
    Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James Lupton Hedrick, Ashlynn Lingzhi Lee, Shrinivas Venkataraman, Yi Yan Yang
  • Publication number: 20120184443
    Abstract: Described are alkoxylated glycerol acetals according to Formulas (Ia) and (Ib) wherein R1 represents a linear or branched, saturated or unsaturated and optionally substituted hydrocarbyl residue comprising 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, a benzyl or furfuryl radical, R2 is selected from hydrogen, an alkyl, alkenyl or hydroxyalkyl group having 6 to 22 carbon atoms or an acyl group having 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, AO represents an ethylene oxide, a propylene oxide, a butylene oxide unit, or their mixtures, and n is an integer of about 1 to about 100.
    Type: Application
    Filed: September 23, 2010
    Publication date: July 19, 2012
    Applicant: Cognis IP Management GmbH
    Inventors: Ingo Fleute-Schlachter, Sandra Heldt, Peter Kempers, Ulrich Schörken, Eckhard Paetzold, Udo Kragl
  • Patent number: 8114903
    Abstract: A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R1 and R2 together form a group —(CH2)n—CR4R5—(CH2)m— wherein n and m are independently selected integers 0, 1 or 2 and R4 and R5 are independently selected from H, C1-18 alkyl, C1-18alkoxy, C1-18n hydroxyalkyl, C2-18 alkenyl and C6-18aryl or aralykyl and R3 is the a fatty acyl group of an essential polyunsaturated fatty acid.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: February 14, 2012
    Assignee: BTG International Limited
    Inventors: Laurence S. Harbige, Michael J. Leach, Paul Barraclough, Anthony P Dolan
  • Publication number: 20110118330
    Abstract: Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described.
    Type: Application
    Filed: July 8, 2009
    Publication date: May 19, 2011
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: Arun K. Ghosh
  • Patent number: 7919523
    Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: April 5, 2011
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Michael R. Hale, Christopher T. Baker, Timothy A. Stammers, Ronald George Sherrill, Andrew Spaltenstein, Eric Steven Furfine, Francois Maltais, Clarence Webster Andrews, III, John Franklin Miller, Vicente Samano
  • Patent number: 7851639
    Abstract: A process for the synthesis of compounds of general formulas comprising the step of reacting in the presence of wherein: R=substituted or unsubstituted alkyl, aryl, heterocycles containing one or more O, N, S, P or B; R1 and R2 independently represent H, substituted or unsubstituted alkyl, aryl, heterocycles containing one or more O, N, S, P or B; R?=H, OH, OR or OSiX3, wherein X independently represent alkyl or aryl.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: December 14, 2010
    Assignee: Girindus AG
    Inventors: Nasir Hayat, Meinolf Lange, Fritz Link, Christiane Neuhaus, Bernhard Westermann
  • Publication number: 20100311795
    Abstract: The present invention relates to novel 1,3-dioxane carboxylic acids of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
    Type: Application
    Filed: February 19, 2007
    Publication date: December 9, 2010
    Inventors: Harikishore Pingali, Pankaj Maganlal Makadia, Braj Bhushan Lohray
  • Publication number: 20100309402
    Abstract: The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, and a suitable elastic constant K33, and further having a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds, and a liquid crystal composition having stability to heat, light and so forth, a low viscosity, a large optical anisotropy, a suitable and negative dielectric anisotropy, and a suitable elastic constant K33, a low threshold voltage, a high maximum temperature (phase-transition temperature on a nematic phase-isotropic phase) of a nematic phase, and a low minimum temperature of the nematic phase. The liquid crystal compound which has a specific structure having fluorine at a lateral position and also having phenylene in which hydrogen on the benzene ring is replaced by fluorine, and a liquid crystal composition containing the compound are prepared.
    Type: Application
    Filed: August 26, 2008
    Publication date: December 9, 2010
    Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATION
    Inventors: Masahide Kobayashi, Teru Shimada
  • Publication number: 20100297196
    Abstract: A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R1 and R2 together form a group —(CH2)n—CR4R5—(CH2)m— wherein n and m are independently selected integers 0, 1 or 2 and R4 and R5 are independently selected from H, C1-18 alkyl, C1-18alkoxy, C1-18hydroxyalkyl, C2-18 alkenyl and C6-18aryl or aralykyl and R3 is the a fatty acyl group of an essential polyunsaturated fatty acid.
    Type: Application
    Filed: July 2, 2010
    Publication date: November 25, 2010
    Applicant: BTG International Limited
    Inventors: Laurence S. Harbige, Michael J. Leach, Paul Barraclough, Anthony P. Dolan
  • Publication number: 20100184986
    Abstract: Organocatalysts, particularly proline sulfonamide organocatalysts, having a first general formula as follows are disclosed. Embodiments of a method for using these organocatalysts also are disclosed. The method comprises providing a disclosed organocatalyst, and performing a reaction, often an enantioselective or diastereoselective reaction, using the organocatalyst. Solely by way of example, disclosed catalysts can be used to perform aldol reactions, conjugate additions, Michael additions, Robinson annulations, Mannich reactions, ?-aminooxylations, ?-hydroxyaminations, ?-aminations and alkylation reactions. Certain of such reactions are intramolecular cyclizations used to form cyclic compounds, such as 5- or 6-membered rings, having one or more chiral centers. Disclosed organocatalysts generally are much more soluble in typical solvents used for organic synthesis than are known compounds.
    Type: Application
    Filed: March 17, 2010
    Publication date: July 22, 2010
    Inventors: Rich Garrett Carter, Hua Yang
  • Patent number: 7745648
    Abstract: A process for preparing 4-fluoro-1,3-dioxolan-2-one comprising adding 4-fluoro-1,3-dioxolan-2-one to ethylene carbonate in an amount of from 3 to 20% by weight relative to the ethylene carbonate as a solvent for the ethylene carbonate, and introducing fluorine or a mixture containing fluorine in an inert gas is introduced into the resulting solution at 15 to 45° C.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: June 29, 2010
    Assignee: Solvay Fluor GmbH
    Inventors: Olaf Boese, Dirk Seffer, Katja Peterkord
  • Publication number: 20100112482
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Inventors: Takeru WATANABE, Satoshi SHINACHI, Takeshi KINSHO, Koji HASEGAWA, Yuji HARADA, Jun HATAKEYAMA, Kazunori MAEDA, Tomohiro KOBAYASHI
  • Patent number: 7704988
    Abstract: This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: April 27, 2010
    Assignee: Merck & Co., Inc.
    Inventors: Robert J. DeVita, Gregori J. Morriello, Peter Lin
  • Publication number: 20100099894
    Abstract: A method for the synthesis of cyclic acetals comprises reacting at least one carbonyl-function compound selected from aldehydes, ketones, and/or linear acetals, on a polyol in a concentrated aqueous solution exceeding 20 wt % in a reactor containing an acidic catalyst. The carbonyl-function compound is selected so that the cyclic acetal obtained has a water solubility lower than 20000 mg/kg. During the catalytic reaction for the cyclic acetal synthesis, at least one portion of the organic phase containing the cyclic acetal is separated. The acidic catalysis is either homogeneous when using a water-soluble strong acid, or heterogeneous when using a solid acid such as a resin, a zeolite, or any appropriately acidified solid. The extractive reaction method can be used for obtaining high conversions and selectivity.
    Type: Application
    Filed: October 8, 2007
    Publication date: April 22, 2010
    Inventors: Jean-Luc Dubois, Sara Iborra Chornet, Alexandra I. Lucienne Velty, Avelino Corma Canos
  • Publication number: 20090311403
    Abstract: A method of using organic compounds and providing slow release flavoring in or for food products wherein flavor precursors are added to flavor compositions and/or food products and release flavor compounds upon consumption of the food products, and novel flavor precursor compounds. The flavor precursors can be prepared from monoglycerides and flavor compounds which comprise one or more carbonyl groups.
    Type: Application
    Filed: July 24, 2007
    Publication date: December 17, 2009
    Applicant: Givaudan SA
    Inventor: Willi Grab
  • Publication number: 20090227713
    Abstract: A phosphorus compound represented by the formula (I): wherein R1 and R2 are, the same or different, a hydrogen atom, a straight or branched-chain alkyl group having 1 to 6 carbon atoms or an aryl group having 6 to 12 carbon atoms which may be optionally substituted for an alkyl group having 1 to 4 carbon atoms, R3, R4, R5, R6 and R7 are, the same or different, a hydrogen atom or an aryl group having 6 to 12 carbon atoms which may be optionally substituted for an alkyl group having 1 to 4 carbon atoms, or R3 and R4, R4 and R5, R5 and R6 or R6 and R7 may form a 6 membered ring with carbon atoms wherein these groups bond a benzene ring provided that R3, R4, R5, R6 and R7 are not hydrogen atoms at the same time.
    Type: Application
    Filed: September 8, 2006
    Publication date: September 10, 2009
    Applicant: DAIHACHI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Makoto Kyoda, Yuki Masui
  • Publication number: 20090137660
    Abstract: A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R1 and R2 together form a group —(CH2)n—CR4R5—(CH2)m— wherein n and m are independently selected integers 0, 1 or 2 and R4 and R5 are independently selected from H, C1-18 alkyl, C1-18 alkoxy, C1-18n hydroxyalkyl, C2-18 alkenyl and C6-18 aryl or aralyalkyl and R3 is the fatty acyl group of an essential polyunsaturated fatty acid.
    Type: Application
    Filed: March 2, 2006
    Publication date: May 28, 2009
    Inventors: Laurence S. Harbige, Michael J. Leach, Paul Barraclough, Anthony P. Dolan
  • Publication number: 20090118357
    Abstract: Therefore the present invention relates specifically to the compounds of general formula (I), in which R1 and R2, which may be identical or different, are selected from the group comprising H, —CnH2n-1, a linear or branched alkyl group having from 1 to 6 carbon atoms, or together form an aromatic or aliphatic ring with 5 or 6 atoms; R3 is selected from —CO—CH3, —NHOH, —OH, —OR6 in which R6 is a linear or branched alkyl group having from 1 to 6 carbon atoms; R4 is selected from H, a linear or branched alkyl group having from 1 to 6 carbon atoms, phenyl, benzyl, —CF3 or —CF2CF3, vinyl or allyl; R5, R7, R8 are hydrogen atoms; or R3 and R4, R4 and R5, or R7 and R8 together form a ring, fused to the benzene, aromatic or aliphatic ring with 5 or 6 atoms comprising from 1 to 2 heteroatoms selected independently from the group comprising N, O, and use thereof in the medical field.
    Type: Application
    Filed: July 24, 2006
    Publication date: May 7, 2009
    Applicant: Giuliani International Limited
    Inventors: Giancarlo Naccari, Sergio Baroni
  • Patent number: 7074462
    Abstract: The invention relates to compounds of the formula I and to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the general formula I in which R, A1, A2, Z1, Y, Z, L1, L2 and m are as defined herein.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: July 11, 2006
    Assignee: Merck Patent GmbH
    Inventors: Matthias Bremer, Michael Heckmeier, Joachim Krause, Detlef Pauluth, Achim Götz, Brigitte Schuler
  • Patent number: 7060727
    Abstract: The present invention relates generally to prodrugs of fused GABA analogs, pharmaceutical compositions of prodrugs of fused GABA analogs, methods of making prodrugs of fused GABA analogs and methods of using prodrugs of fused GABA analogs and pharmaceutical compositions of prodrugs of fused GABA analogs to treat or prevent various diseases.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: June 13, 2006
    Assignee: XenoPort, Inc.
    Inventor: Mark A. Gallop
  • Patent number: 6916347
    Abstract: Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R1 and R2 are each individually selected from a hydrogen atom, a C1 to C3 alkyl group, a C1 to C5 mono or dihydroxyalkyl group, phenyl or benzyl optionally substituted with an alkoxy group, or R1 and R2 together with the nitrogen atom to which they are attached form a piperazine, piperidine, imidazole, or morpholine ring.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: July 12, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Mu-Ill Lim, Yuh-Guo Pan
  • Patent number: 6849747
    Abstract: Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain alkyl (or alkoxy) substituted fluoro-benzylidene sorbitol acetals and polymer compositions thereof which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive fluorinated and alkylated benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: February 1, 2005
    Assignee: Milliken & Company
    Inventors: John D. Anderson, Nathan A. Mehl
  • Patent number: 6838568
    Abstract: Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain alkyl (or alkoxy) substituted fluoro-benzylidene sorbitol acetals and polymer compositions thereof which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive fluorinated and alkylated benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: January 4, 2005
    Assignee: Milliken & Company
    Inventors: John D. Anderson, Nathan A. Mehl
  • Patent number: 6806375
    Abstract: Intermediates such as methyl 2,2-dimethyl-5-ethenyl-1,3-dioxane-5-carbonate useful to prepare antiviral compounds such as penciclovir and famciclovir are disclosed.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: October 19, 2004
    Assignee: Novartis International Pharmaceutical Ltd.
    Inventors: Richard Freer, Graham Richard Geen, Thomas Weir Ramsay, Andrew Colin Share, Neil Michael Smith
  • Patent number: 6803488
    Abstract: The present invention provides a process whereby fluorinated ketones of various structures can be produced by short process steps and which is useful as an industrial production process.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: October 12, 2004
    Assignee: Asahi Glass Company, Limited
    Inventors: Takashi Okazoe, Kunio Watanabe, Masahiro Ito, Daisuke Shirakawa, Shin Tatematsu, Hirokazu Takagi
  • Patent number: 6750355
    Abstract: Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R1 and R2 are each individually selected from a hydrogen atom, a C1 to C3 alkyl group, a C1 to C5 mono or dihydroxyalkyl group, phenyl or benzyl optionally substituted with an alkoxy group, or R1 and R2 together with the nitrogen atom to which they are attached form a piperazine, piperidine, imidazole, or morpholine ring.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: June 15, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Mu-Ill Lim, Yuh-Guo Pan
  • Patent number: 6673932
    Abstract: Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R is hydrogen, hydroxy, nitro, amino, halogen, C1 to C5 alkyl or haloalkyl, C1 to C5 alkoxy or cyclic alkoxy, C1 to C5 hydroxyalkyl and C1 to C5 hydroxyalkoxy; Ar is an aromatic group; and y=1 to 3.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: January 6, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Mu-Ill Lim, Yuh-Guo Pan
  • Patent number: 6646132
    Abstract: An information recording medium is disclosed, comprising a substrate having provided thereon a recording layer capable of recording information by a laser ray, wherein the recording layer contains a dye compound represented by formula (I-1): wherein R1, R2, R3 and R4 each independently represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group or a substituted or unsubstituted heterocyclic group, L1, L2 and L3 each independently represents a methine group which may have a substituent, m represents 0, 1, 2 or 3, Xk+ represents a cation and k represents an integer of from 1 to 10, provided that when m is 2 or 3, the plurality of L2 and L3 groups may be the same or different. Also disclosed is an information recording method using the above-described information recording medium.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: November 11, 2003
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Shin-ichi Morishima, Michihiro Shibata, Yoshihisa Usami
  • Patent number: 6617350
    Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: September 9, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael R. Hale, Christopher T. Baker, Timothy A. Stammers, Ronald George Sherrill, Andrew Spaltenstein, Eric Steven Furfine, François Maltais, Clarence Webster Andrews, III, John Franklin Miller, Vicente Samano
  • Patent number: 6613743
    Abstract: The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity. The sulfonamides of formula I have the structure: wherein A, B, D, D′, E, G and R7 are as defined above.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: September 2, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Robin Hale, Clarence Webster Andrews, III, Eric Steven Furfine, Ronald George Sherrill, Andrew Spaltenstein, Gregory Thomas Lowen
  • Publication number: 20030139612
    Abstract: Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain alkyl (or alkoxy) substituted fluoro-benzylidene sorbitol acetals and polymer compositions thereof which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive fluorinated and alkylated benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.
    Type: Application
    Filed: September 13, 2002
    Publication date: July 24, 2003
    Inventors: John D. Anderson, Nathan A. Mehl