The Ring Oxygens Are In The 1,3-positions Of The Hetero Ring (e.g., 1,3 Dioxane, Etc.) Patents (Class 549/369)
  • Publication number: 20150129800
    Abstract: The instant invention relates to mesogenic media comprising one or more compounds of formula D wherein the parameters are as specified in the text, preferably to mesogenic media showing a blue phase, preferably stabilised by a polymer, and their use in electro-optical light modulation elements and their respective use in displays, as well as to such devices.
    Type: Application
    Filed: April 3, 2013
    Publication date: May 14, 2015
    Inventors: Michael Wittek, Malgorzata Rillich
  • Patent number: 9029576
    Abstract: The present invention is directed to 5-sec-butyl-2-(2,4-dimethyl-cyclohex-3-enyl)-5-methyl-[1,3]dioxane and a novel process for making the same.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: May 12, 2015
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Juan Adell Gavalda, Anubhav P. S. Narula, Ana Maria Collado Perez
  • Publication number: 20150069297
    Abstract: A liquid crystal compound having high stability to heat and light, etc., a high clearing point, a low minimum temperature of liquid crystal phase, a low viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant, and good compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound, and a LCD element using the composition are described. The compound is represented by formula (1): wherein, for example, R1 is C1-10 alkyl, ring A1, ring A2, ring A3, ring A4 and ring B1 are independently 1,4-cyclohexylene, 1,4-phenylene, 1,4-phenylene in which at least one hydrogen is substituted with halogen, 1,3-dioxane-2,5-diyl, or tetrahydropyran-2,5-diyl, Z1, Z2, Z3 and Z4 are single bonds, l, m, n and o are independently 0 or 1, and l+m+n+o?1.
    Type: Application
    Filed: February 7, 2013
    Publication date: March 12, 2015
    Inventor: Hiroyuki Tanaka
  • Patent number: 8969598
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction vessel at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a homogeneous acid catalyst to generate a liquid phase homogeneous reaction mixture containing the acid catalyst without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid phase homogeneous reaction mixture from the reaction vessel as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds and/or acid catalyst to the reaction vessel. The process produces cyclic acetal compounds in high yields. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Eastman Chemical Company
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Patent number: 8969405
    Abstract: In one aspect, the invention relates to compounds having anticancer activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended to be used as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: March 3, 2015
    Assignee: St. Jude Children's Research Hospital
    Inventors: Thomas R. Webb, Chandraiah Lagisetti
  • Patent number: 8956552
    Abstract: To provide a compound, when the compound has both a high clearing point and a low crystallization temperature, having a wide temperature range of a liquid crystal phase and also an excellent solubility in other liquid crystal compounds, and further having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a suitable optical anisotropy and a suitable dielectric anisotropy. A compound is represented by formula (1): wherein, for example, Ra and Rb are alkyl having 1 to 10 carbons; A1, A2, A3 and A4 are 1,4-phenylene; Z1, Z2, Z3 and Z4 are a single bond or alkylene having 1 to 4 carbons; and m, n, q and r are independently 0, 1, or 2, and a sum of m, n, q and r is 1, 2, 3 or 4.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: February 17, 2015
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventor: Yasuyuki Sasada
  • Patent number: 8956551
    Abstract: A liquid crystal compound having a high stability to heat, light and so forth, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant and an excellent solubility in other liquid crystal compounds, a liquid crystal composition containing the compound, and a liquid crystal display device including the composition. The compound is represented by formula (1): wherein, for example, R1 is fluorine or alkyl having 1 to 10 carbons; ring A1 and ring A2 are 1,4-phenylene, or 1,4-phenylene in which at least one of hydrogen is replaced by fluorine; Z1, Z2 and Z3 are a single bond; L1 and L2 are hydrogen or fluorine; X1 is fluorine or —CF3; and m is 1, and n is 0.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: February 17, 2015
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventors: Yasuyuki Gotoh, Keiji Kimura
  • Patent number: 8940185
    Abstract: To provide a novel liquid crystal compound having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large refractive index anisotropy, a large dielectric anisotropy and a small viscosity. The liquid crystal compound is provided as compound (1): wherein, for example, R1 is alkyl having 1 to 20 carbons; ring A1 and ring B1 are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond, —CH2CH2—, —CH?CH— or —C?C—; L1 is fluorine; L2, Y1 and Y2 are hydrogen, fluorine or chlorine; and X1 is halogen, —C?N or alkyl having 1 to 10 carbons, and in the alkyl, arbitrary —CH2— may be replaced by —O— or —S—, and m is 1 and n is 0.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: January 27, 2015
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventor: Hiroyuki Tanaka
  • Publication number: 20140378360
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 25, 2014
    Inventors: Hugo Robert Germain DENUTTE, Johan SMETS, An PINTENS, Koen VAN AKEN, Freek Annie Camiel VRIELYNCK
  • Publication number: 20140357875
    Abstract: Cyclic acetals can be produced in a reactive distillation apparatus by combining a polyhydroxyl compound and an aldehyde. High concentrations of cyclic acetals are removed as liquid products from the column while water is removed as an overhead vapor stream.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 4, 2014
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Damon Ray Billodeaux, Robert Scott Huss, Daniel Latham Terrill, Jerome Leonard Stavinoha, JR.
  • Publication number: 20140312275
    Abstract: This invention relates to liquid crystal compound of formula I containing benzene derivatives group that hydrogen substituted by deuterium. Liquid crystal compounds of formula I have not only large positive dielectric anisotropy, but also moderate optical anisotropy and driving voltage, thereby having great significance to formulate a liquid crystal mixture. A liquid crystal mixture containing such type of liquid crystal compounds can be applied in various display devices, which is particularly suitable for TN and STN display devices, and can also be used in IPS and VA display devices.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Inventors: Ze Feng HOU, Wen Hai LU, Xing ZHANG, Guo Liang YUN, Rui Mao HUA, Ming LI, Lei ZHAO
  • Patent number: 8834744
    Abstract: The invention relates to a liquid-crystalline medium comprising one or more compounds of the formula I in which R0, X0 and L1-6 have the meanings indicated in Claim 1, and to the use thereof in electro-optical liquid-crystal displays.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: September 16, 2014
    Assignee: Merck Patent GmbH
    Inventors: Michael Wittek, Brigitte Schuler, Reiffenrath Volker, Mark Goebel, Markus Czanta
  • Patent number: 8829207
    Abstract: Cyclic acetals can be produced in a reactive distillation apparatus by combining a polyhydroxyl compound and an aldehyde. High concentrations of cyclic acetals are removed as liquid products from the column while water is removed as an overhead vapor stream.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 9, 2014
    Assignee: Eastman Chemical Company
    Inventors: Damon Ray Billodeaux, Robert S. Huss, Daniel Latham Terrill, Jerome Leonard Stavinoha, Jr.
  • Publication number: 20140213620
    Abstract: In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.
    Type: Application
    Filed: July 17, 2013
    Publication date: July 31, 2014
    Inventors: James Elliot Bradner, Ralph Mazitschek
  • Publication number: 20140081034
    Abstract: The present invention is directed to 5-sec-butyl-2-(2,4-dimethyl-cyclohex-3-enyl)-5-methyl-[1,3]dioxane and a novel process for making the same.
    Type: Application
    Filed: September 3, 2013
    Publication date: March 20, 2014
    Applicant: International Flavors & Fragrances Inc.
    Inventors: Juan Adell Gavalda, Anubhav P.S. Narula, Ana Maria Collado Perez
  • Publication number: 20140021406
    Abstract: A liquid crystal compound having a high stability to heat, light and so forth, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant and an excellent solubility in other liquid crystal compounds, a liquid crystal composition containing the compound, and a liquid crystal display device including the composition. The compound is represented by formula (1): wherein, for example, R1 is fluorine or alkyl having 1 to 10 carbons; ring A1 and ring A2 are 1,4-phenylene, or 1,4-phenylene in which at least one of hydrogen is replaced by fluorine; Z1, Z2 and Z3 are a single bond; L1 and L2 are hydrogen or fluorine; X1 is fluorine or —CF3; and m is 1, and n is 0.
    Type: Application
    Filed: July 10, 2013
    Publication date: January 23, 2014
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Yasuyuki GOTOH, Keiji KIMURA
  • Patent number: 8574456
    Abstract: The invention relates to a liquid-crystalline medium comprising one or more compounds of the formula I in which R0, X0 and L1-6 have the meanings indicated in Claim 1, and to the use thereof in electro-optical liquid-crystal displays.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: November 5, 2013
    Assignee: Merck Patent GmbH
    Inventors: Michael Wittek, Brigitte Schuler, Volker Reiffenrath, Mark Goebel, Markus Czanta
  • Publication number: 20130277612
    Abstract: To provide a compound, when the compound has both a high clearing point and a low crystallization temperature, having a wide temperature range of a liquid crystal phase and also an excellent solubility in other liquid crystal compounds, and further having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a suitable optical anisotropy and a suitable dielectric anisotropy. A compound is represented by formula (1): wherein, for example, Ra and Rb are alkyl having 1 to 10 carbons; A1, A2, A3 and A4 are 1,4-phenylene; Z1, Z2, Z3 and Z4 are a single bond or alkylene having 1 to 4 carbons; and m, n, q and r are independently 0, 1, or 2, and a sum of m, n, q and r is 1, 2, 3 or 4.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 24, 2013
    Applicants: JNC CORPORATION
    Inventor: Yasuyuki SASADA
  • Publication number: 20130270480
    Abstract: To provide a compound, when the compound has both a high clearing point and a low crystallization temperature, having a wide temperature range of a liquid crystal phase and also an excellent solubility in other liquid crystal compounds, and further having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a suitable optical anisotropy and a suitable dielectric anisotropy. A compound is represented by formula (1): wherein, for example, Ra and Rb are alkyl having 1 to 10 carbons; A1, A2, A3 and A4 are 1,4-phenylene; Z1, Z2, Z3 and Z4 are a single bond or alkylene having 1 to 4 carbons; and m, n, q and r are independently 0, 1, or 2, and a sum of m, n, q and r is 1, 2, 3 or 4.
    Type: Application
    Filed: October 13, 2011
    Publication date: October 17, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventor: Yasuyuki Sasada
  • Publication number: 20130271719
    Abstract: To provide a liquid crystal compound having a large positive value of dielectric anisotropy and a small viscosity. The compound is represented by formula (1): wherein, in formula (1), R1 is alkyl having 1 to 20 carbons or the like; ring A1 is 1,4-cyclohexylene or the like; ring A2 is 1,4-phenylene, 2-fluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene or the like; ring A3 is 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene or the like; and X1 is halogen, alkyl having 1 to 10 carbons or the like, and in the alkyl, at least one of hydrogen may be replaced by halogen.
    Type: Application
    Filed: April 4, 2013
    Publication date: October 17, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Takahiro KUBO, Yasuyuki GOTOH
  • Patent number: 8536196
    Abstract: Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: September 17, 2013
    Assignee: Evolva SA
    Inventors: Alexandra Santana Sorensen, Jean-Philippe Meyer, Peteris Alberts, Prathama S. Mainkar, Melya Hughes Crameri, Thierry Bonnaud, Joanne Kelleher, David Pearson
  • Publication number: 20130208227
    Abstract: The present invention relates to a switch element, which is thermoresponsive and which switches between a less transmissive state for radiant energy and a more transmissive state for radiant energy, and which comprises a liquid-crystalline medium. The invention furthermore relates to the use of the switch element for the regulation of radiant energy flow between interior spaces and the environment and for the regulation of the temperature of interior spaces. The invention furthermore relates to a liquid-crystalline medium, characterised in that it comprises a compound of the formula (I), in particular for use in the switch elements according to the invention.
    Type: Application
    Filed: September 21, 2011
    Publication date: August 15, 2013
    Applicant: Merck Patent GmbH
    Inventor: Michael Junge
  • Publication number: 20130158219
    Abstract: The invention relates to compounds, in particular phosphinic ligands of metal complexes, as well as to metal complexes including said ligands and to supported catalysts including said metal complexes or said compounds. The invention also relates to methods for synthesizing said compounds, to complexes, and to supported catalysts, as well as to intermediate products used in said synthesis methods. The invention further relates to the uses of said compounds. The compounds of the invention are ferrocene compounds which have been functionalized so as to be capable of being heterogenized. The invention can be used in particular in the field of heterogeneous catalysis.
    Type: Application
    Filed: June 24, 2011
    Publication date: June 20, 2013
    Applicants: Universite de Bourgogne, Centre National De La Recherche Scientifique
    Inventors: Jean-Cyrille Hierso, Matthieu Beauperin, Philippe Meunier
  • Publication number: 20130119310
    Abstract: To provide a novel liquid crystal compound having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large refractive index anisotropy, a large dielectric anisotropy and a small viscosity. The liquid crystal compound is provided as compound (1): wherein, for example, R1 is alkyl having 1 to 20 carbons; ring A1 and ring B1 are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond, —CH2CH2—, —CH?CH— or —C?C—; L1 is fluorine; L2, Y1 and Y2 are hydrogen, fluorine or chlorine; and X1 is halogen, —C?N or alkyl having 1 to 10 carbons, and in the alkyl, arbitrary —CH2— may be replaced by —O— or —S—, and m is 1 and n is 0.
    Type: Application
    Filed: December 20, 2010
    Publication date: May 16, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventor: Hiroyuki Tanaka
  • Publication number: 20120329696
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: May 24, 2012
    Publication date: December 27, 2012
    Inventors: Hugo Robert Germain Denutte, Johan Smets, An Pintens, Jeanne Alfons Van Aken, Freek Annie Camiel Vrielynck
  • Publication number: 20120330033
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction vessel at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a homogeneous acid catalyst to generate a liquid phase homogeneous reaction mixture containing the acid catalyst without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid phase homogeneous reaction mixture from the reaction vessel as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds and/or acid catalyst to the reaction vessel. The process produces cyclic acetal compounds in high yields. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 27, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Publication number: 20120330034
    Abstract: Cyclic acetals can be produced in a reactive distillation apparatus by combining a polyhydroxyl compound and an aldehyde. High concentrations of cyclic acetals are removed as liquid products from the column while water is removed as an overhead vapor stream.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 27, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Damon Ray Billodeaux, Robert S. Huss, Daniel Latham Terrill, Jerome Leonard Stavinoha, JR.
  • Patent number: 8252389
    Abstract: The invention relates to novel mesogenic dimeric compounds which are especially suitable for use in birefringent films with negative optical dispersion, to novel liquid crystal (LC) formulations and polymer films comprising them, and to the use of the dimers, formulations and films in optical, electrooptical, electronic, semiconducting or luminescent components or devices.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: August 28, 2012
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Kevin Adlem, Owain Llyr Parri, Karl Skjonnemand, David Wilkes
  • Patent number: 8211513
    Abstract: The present invention relates to liquid-crystalline compounds having at least three fluorine-substituted benzene rings, a terminal trifluoromethyl group and at least one —CF2O— bridge. The invention also relates to liquid-crystalline media prepared therewith and to liquid-crystal display devices (LC displays) containing these media.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: July 3, 2012
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Axel Jansen, Helmut Haensel, Philipp Krattiger, Andreas Taugerbeck, Malgorzata Rillich
  • Patent number: 8197709
    Abstract: The present invention relates to chemical compounds containing five or more benzene rings arranged in a linear manner and two bridging units between these rings, where at least one of these units represents a —CF2O— bridge. The invention additionally relates to liquid-crystalline media and to high-frequency components comprising these media, in particular antennae, especially for the gigahertz range.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: June 12, 2012
    Assignee: Merck Patent Gesellschaft mit berschrankter Haftung
    Inventors: Lars Lietzau, Werner Binder, Atsutaka Manabe, Helmut Haensel
  • Patent number: 8188030
    Abstract: Disclosed herein is a fabric softener composition comprising a fabric softener active compound that comprises a quarternary ammonium salt and/or an imidazolinium salt, and a ketal adduct of formula (12) wherein R1 is C1-6 alkyl, R2 is hydrogen or C1-3 alkyl, each R3 and R4, is independently hydrogen or C1-6 alkyl, each R5 and R6 is independently hydrogen or C1-6 alkyl, or hydroxymethyl, R7 is hydrogen, C1-6 alkyl, C1-6 alkyl substituted with up to four OR8 groups wherein R8 is hydrogen, C1-6 alkyl, or acetyl, a is 0-3, and b is 0-1.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: May 29, 2012
    Assignee: Segetis, Inc.
    Inventors: Lee Richard Rieth, Dorie J. Yontz, Daniel Warren Gilbert
  • Patent number: 8178579
    Abstract: In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2, R3, n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: May 15, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Scott M. Sternson, Jason C. Wong, Christina M. Grozinger, Stephen J. Haggarty, Kathryn M. Koeller
  • Patent number: 8158564
    Abstract: A compound which satisfies requirements for the annealing property and the lubricating property simultaneously and a process for producing the compound are provided. The compound is an alkylacetal compound represented by the following general formula (1) or (2). In the general formulae, R1 and R2 represent hydrocarbon groups, R3 to R8 represent hydrogen atom or hydrocarbon groups, i and j represent integers satisfying the relation that the sum of the integers is 8 to 98, and k represents 0 or 1.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: April 17, 2012
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Haruhito Sato, Akihiro Shishikura
  • Patent number: 8114902
    Abstract: Disclosed is a 2-aminobutanol compound represented by the following formula (I) or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof, as well as a production method of the 2-aminobutanol compound of formula (I). The 2-aminobutanol compounds of formula (I) have few side effects including bradycardia and have superior peripheral blood lymphocyte-decreasing effects.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: February 14, 2012
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Masatoshi Kiuchi, Mitsuharu Nakamura, Maiko Hamada, Kunio Sugahara
  • Publication number: 20120010114
    Abstract: Acetal derivatives of 2,2,3,6-tetramethyl-1-cyclohexane/ene-carbaldehyde of formula (I): for use in the perfumery industry as well as the resulting compositions or articles containing one or more of these compounds. In formula (I), one dotted line indicates the presence of a carbon-carbon single or double bond and the other dotted line indicates the presence of a carbon-carbon single bond, R1 represents a hydrogen atom or a methyl or ethyl group; and each R, taken alone, simultaneously or independently, represents a C1-3 alkyl or alkenyl group, or the R groups, taken together, represent a C2-6 hydrocarbon group optionally including an oxygen atom.
    Type: Application
    Filed: April 14, 2010
    Publication date: January 12, 2012
    Inventors: Philippe Dupau, Murielle Haldimann Sanchez
  • Patent number: 8021571
    Abstract: The invention relates to chiral reactive mesogen (RM) mixtures, polymer films obtained thereof, and the use of the mixtures and polymer films in optical, electrooptical or electronic components or devices, in decorative, security or cosmetic applications, especially for use in broadband reflective polarizers.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: September 20, 2011
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Alison Linda May, Owain Llyr Parri
  • Patent number: 7951432
    Abstract: A liquid crystal compound represented by formula (1), a liquid crystal composition comprising the compound, and a liquid crystal display device comprising the composition: For example, R1 is alkyl having 1 to 20; ring A1, ring A2, ring A3, ring A4, ring A5, and ring A6 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2, Z3, Z4, Z5, and Z6 is a single bond; X1 is hydrogen or halogen; l, m, n, o, p, and q are 0 or 1, and l+m+n+o+p+q is 3.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: May 31, 2011
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventor: Hiroyuki Tanaka
  • Patent number: 7951433
    Abstract: The invention provides a five-ring liquid crystal compound having a CF2O bonding group as a new compound having a general physical properties necessary for compounds, stability to heat, light and so forth, a wide temperature range of liquid crystal phases, a high clearing point, a good compatibility with other compounds, a large dielectric anisotropy and refractive index anisotropy, and an especially high clearing point and an especially large refractive index anisotropy, and provides a liquid crystal composition and a liquid crystal display device.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: May 31, 2011
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventor: Hiroyuki Tanaka
  • Patent number: 7928252
    Abstract: Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: wherein R represents an aryl group such as p-methoxyphenyl. This compound can be reacted with a lower alkyl aluminum compound to open the dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required ?-side chain and then the required ?-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: April 19, 2011
    Assignee: Alphora Research Inc.
    Inventors: Dino Alberico, Joshua Clayton, Boris Ivanovich Gorin, Jan Oudenes
  • Publication number: 20110001089
    Abstract: The invention relates to a liquid-crystalline medium comprising one or more compounds of the formula I in which R0, X0 and L1-6 have the meanings indicated in Claim 1, and to the use thereof in electro-optical liquid-crystal displays.
    Type: Application
    Filed: February 18, 2009
    Publication date: January 6, 2011
    Applicant: Merck Patent Gesellschaft
    Inventors: Michael Wittek, Brigitte Schuler, Volker Reiffenrath, Mark Goebel, Markus Czanta
  • Publication number: 20100324001
    Abstract: Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.
    Type: Application
    Filed: June 30, 2010
    Publication date: December 23, 2010
    Applicant: Cortical Pty LTD
    Inventors: Eric Francis Morand, Magdy Naguib Iskander, Colin Edward Skene
  • Publication number: 20100309402
    Abstract: The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, and a suitable elastic constant K33, and further having a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds, and a liquid crystal composition having stability to heat, light and so forth, a low viscosity, a large optical anisotropy, a suitable and negative dielectric anisotropy, and a suitable elastic constant K33, a low threshold voltage, a high maximum temperature (phase-transition temperature on a nematic phase-isotropic phase) of a nematic phase, and a low minimum temperature of the nematic phase. The liquid crystal compound which has a specific structure having fluorine at a lateral position and also having phenylene in which hydrogen on the benzene ring is replaced by fluorine, and a liquid crystal composition containing the compound are prepared.
    Type: Application
    Filed: August 26, 2008
    Publication date: December 9, 2010
    Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATION
    Inventors: Masahide Kobayashi, Teru Shimada
  • Patent number: 7846514
    Abstract: The invention provides a liquid crystal compound which has stability to heat, light and so forth, shows liquid crystal phases in a wide temperature range, and has a small viscosity, an appropriate optical anisotropy, a large dielectric anisotropy, and an excellent compatibility with other liquid crystal compounds. The invention provides a liquid crystal composition which has an appropriate optical anisotropy, an appropriate dielectric anisotropy, a low threshold voltage, and a high maximum temperature and a low minimum temperature of a nematic phase. The invention provides a liquid crystal display device which has a short response time, a small power consumption, a small driving voltage, and a large contrast, and can be used in a wide temperature range. The liquid crystal compound is a halogeno-benzene derivative having a trifluoropropenyl group or trifluoropropynyl group at a side chain, such as, for example, trans-4?-[3,5-difluoro-4-(3,3,3-trifluoropropenyl)phenyl]-trans-4-propylbicyclohexyl.
    Type: Grant
    Filed: January 15, 2008
    Date of Patent: December 7, 2010
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventor: Teru Shimada
  • Patent number: 7846513
    Abstract: A compound represented by the following formula (1), a liquid crystal composition containing the compound and a liquid crystal display device containing the composition: all the symbols in the formula (1) are defined in the specification.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: December 7, 2010
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventor: Yasuyuki Sasada
  • Patent number: 7838692
    Abstract: A compound which satisfies requirements for the annealing property and the lubricating property simultaneously and a process for producing the compound are provided. The compound is an alkylacetal compound represented by the following general formula (1) or (2). In the general formulae, R1 and R2 represent hydrocarbon groups, R3 to R8 represent hydrogen atom or hydrocarbon groups, i and j represent integers satisfying the relation that the sum of the integers is 8 to 98, and k represents 0 or 1.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: November 23, 2010
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Haruhito Sato, Akihiro Shishikura
  • Patent number: 7785675
    Abstract: A compound represented by the following general formula (I). (In the formula, R1 is hydrogen or C1-8 alkyl; ring A is 1,4-phenylene, 1,4-trans-cyclohexylene, or 2,6-naphthylene; Z1 and Z2 each are —COO—, —OCO—, —CH2O—, —OCH2—, —CH2CH2—, —CH?CH—, —C?C—, or a single bond; m is 1 or 2; n is 0 or 1; X1 and X2 each are C1-3 alkyl or alkoxy or hydrogen, provided that when one of X1 and X2 is hydrogen, the other must not be hydrogen; Y1 and Y2 each are hydrogen, fluorine, or chlorine; Q is C1-8 saturated or unsaturated alkyl in which all or part of the hydrogen atoms are replaced by a halogen atom; and L is oxygen atom or a single bond.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: August 31, 2010
    Assignee: Adeka Corporation
    Inventors: Masatomi Irisawa, Tomohisa Miura, Hirokatsu Shinano
  • Patent number: 7767277
    Abstract: Disclosed are compounds of formula I processes for the preparation thereof, and liquid-crystalline media and electro-optical displays containing said compounds.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: August 3, 2010
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Lars Lietzau, Markus Czanta, Harald Hirschmann, Michael Wittek
  • Patent number: 7728069
    Abstract: Disclosed are reactive cyclic carbonates and ureas of formula (I) or (II), wherein R and X have the meaning indicated in the description. Said carbonates and ureas allow functional groups to be specifically introduced into biomolecules, polymers, and surfaces in mild conditions.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: June 1, 2010
    Assignee: Henkel AG & Co. KGaA
    Inventors: Helmut Keul, Martin Möller, Nicolas Pasquier, Luc Ubaghs
  • Patent number: 7691456
    Abstract: The invention relates to novel dioxane derivatives of the formula R1-(A1-Z1)m-G-(Z2-A2)n-R2, in which G denotes (I) or (II), and in which R1, R2, A1, A2, Z1, Z2, m and n have the meanings indicated in claim 1, to the use thereof as component(s) of liquid-crystalline media, and to liquid-crystal and electro-optical display elements which contain the liquid-crystalline media according to the invention.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: April 6, 2010
    Assignee: Merck Patent Gesellschaft
    Inventors: Lars Lietzau, Werner Binder, Melanie Klasen-Memmer, Eike Poetsch, Markus Czanta
  • Publication number: 20100056588
    Abstract: In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.
    Type: Application
    Filed: February 14, 2007
    Publication date: March 4, 2010
    Inventors: James Elliot Bradner, Ralph Mazitschek