The Chalcogen, X, Is In A -c(=x)- Group Patents (Class 549/375)
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Publication number: 20080124426Abstract: Ketomethionine ketals and hemiketals and derivatives thereof are useful as feed additives, in particular for the nutrition of ruminants.Type: ApplicationFiled: November 20, 2007Publication date: May 29, 2008Applicant: EVONIK DEGUSSA GmbHInventors: Christoph Kobler, Martin Hateley, Philipp Roth, Barbara Jaeger, Rainer Peter, Christoph Weckbecker, Klaus Huthmacher
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Patent number: 7354950Abstract: A composition includes at least one compound represented by the following Formula (1). In the Formula (1), R1 represents an alkyl group having 1 to 18 carbon atoms, R2 represents a hydrogen atom or a substituent, and R3 represents a substituent, m represents an integer of from 0 to 4, and n represents an integer of from 1 to 5.Type: GrantFiled: February 21, 2007Date of Patent: April 8, 2008Assignee: Fujifilm CorporationInventors: Koji Takaku, Akihide Osaku
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Publication number: 20080033036Abstract: The present invention provides a method and composition for promoting hair growth in a mammal which comprises a prostaglandin compound having two hetero atoms at the 15 position as an active ingredient thereof.Type: ApplicationFiled: August 12, 2004Publication date: February 7, 2008Inventors: Ryuji Ueno, Tsuyoshi Habe, Takashi Sekida
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Publication number: 20070194278Abstract: A composition includes at least one compound represented by the following Formula (1). In the Formula (1), R1 represents an alkyl group having 1 to 18 carbon atoms, R2 represents a hydrogen atom or a substituent, and R3 represents a substituent. m represents an integer of from 0 to 4, and n represents an integer of from 1 to 5.Type: ApplicationFiled: February 21, 2007Publication date: August 23, 2007Inventors: Koji Takaku, Akihide Osaku
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Patent number: 7205418Abstract: The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-?-hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in which said compound of formula (I) is useful for preparing the therapeutic agent for hyperlipidemia, such as Astrovastatin and Fluvastatin. Wherein R1 denotes a hydrogen atom, alkyl, aryl or alkylaryl, R2 and R3 which can be identical or different, are a lower alkyl or phenyl and are capable of forming a six-membered ring, R4 stands for hydroxy, amino, alkylamino, azido, cyano, halogeno, aryloxy, alkyloxy, arylalkyloxy, alkyl, alkenyl, aryl, or aminomethyl, etc.Type: GrantFiled: August 13, 2002Date of Patent: April 17, 2007Assignee: Choongwae Pharma CorporationInventors: Inhee Lee, Seungjoo Lee
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Patent number: 7176323Abstract: A process for the production of a ?-ketoacetal compound wherein the desired product is obtained by a simple procedure in a high yield as a high purity product. The reaction scheme for the process is as follows: wherein Ar is an aryl group; X is a halogen atom; Ra and Rb is an alkyl or alkoxy group; and W is an alkylene group.Type: GrantFiled: February 9, 2005Date of Patent: February 13, 2007Assignee: Sankyo Company, LimitedInventors: Rei Okazaki, Shunshi Kojima
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Patent number: 7161004Abstract: Intermediate compounds for preparing rosuvastatin are prepared by a process comprising oxidizing hydroxy groups to aldehyde groups, using sodium hypochlorite and 2,2,6,6-tetramethyl piperidinyl oxy free radical (TEMPO) as a catalyst.Type: GrantFiled: June 21, 2005Date of Patent: January 9, 2007Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.Inventors: Srinivasulu Gudipati, Srinivas Katkam, Rajeshwar Reddy Sagyam, Jaya Satyanaraya Kudavalli
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Patent number: 7045641Abstract: A process for preparing compounds of the formula I is described and entails converting a compound of the formula II by Wittig or Wittig-Horner reaction into a compound of the formula IV, where appropriate converting the compound of the formula IV by hydrolysis of the acetal function and Wittig or Wittig-Horner reaction into a compound of the formula VI and converting the compound of the formula IV or VI in two stages into the compound of the formula I. The radicals R1, R2 and R6 and k have the meaning indicated in the description. Novel intermediates are also described.Type: GrantFiled: January 6, 2003Date of Patent: May 16, 2006Assignee: BASF AktiengesellschaftInventors: Hansgeorg Ernst, Klaus Henrich
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Patent number: 6933385Abstract: The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.Type: GrantFiled: August 5, 2002Date of Patent: August 23, 2005Assignee: Schering AGInventors: Jurgen Westermann, Johannes Platzek, Orlin Petrov
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Patent number: 6903225Abstract: This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions. A process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprises reacting an acetic acid derivative at a temperature of not less than ?30° C.Type: GrantFiled: September 13, 2002Date of Patent: June 7, 2005Assignee: Kaneka CorporationInventors: Noriyuki Kizaki, Yukio Yamada, Yoshihiko Yasohara, Akira Nishiyama, Makoto Miyazaki, Masaru Mitsuda, Takeshi Kondo, Noboru Ueyama, Kenji Inoue
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Patent number: 6870059Abstract: The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula (1), where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon atoms from 4-hydroxy-6-X-substituted-methyl-tetrahydropyran-2-one compounds, where X is as defined above, with the aid of an acetalization agent, in the presence of an acid catalyst. The invention also relates to the novel compounds of formula (1) as well as salts and acids to be prepared from these, with the OR3 group in formula (1) being replaced by an OY group, where X, R1 and R2 have the meanings defined above and where Y stands for an alkaline (earth) metal or a substituted or unsubstituted ammonium group or stands for hydrogen, and to the novel compounds of formula (2). The products concerned are, after conversion into the t-butyl ester of 2-(6-hydroxymethyl-1,3-dioxane-4-yl)acetic acid, important as intermediary products in the preparation of statins.Type: GrantFiled: July 12, 2001Date of Patent: March 22, 2005Assignee: Astrazeneca UK Ltd.Inventors: Jacob Hermanus Mattheus Hero Kooistra, Hubertus Josephus Marie Zeegers, Daniel Mink, Joannes Maria Cornelis Antonius Mulders
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Patent number: 6803488Abstract: The present invention provides a process whereby fluorinated ketones of various structures can be produced by short process steps and which is useful as an industrial production process.Type: GrantFiled: February 26, 2003Date of Patent: October 12, 2004Assignee: Asahi Glass Company, LimitedInventors: Takashi Okazoe, Kunio Watanabe, Masahiro Ito, Daisuke Shirakawa, Shin Tatematsu, Hirokazu Takagi
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Patent number: 6610892Abstract: The invention relates to a process for preparing 2,7-dimethyl-2,4,6-octatrienal monoacetals of the general formula I which comprises a) condensing an ester phosphonium salt of the general formula II or an ester phosphonate of the general formula III with an aldehyde of the formula IV in a Wittig or Wittig-Horner reaction to give an acetal ester of the general formula V b) reducing the ester of the formula V to give an acetal alcohol of the general formula VI and c) oxidizing the alcohol to 2,7-dimethyl-2,4,6-octatrienal monoacetals of the general formula I, where the substituents have the meaning defined in the description.Type: GrantFiled: March 12, 2002Date of Patent: August 26, 2003Assignee: BASF AktiengesellschaftInventors: Hansgeorg Ernst, Klaus Henrich
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Patent number: 6610216Abstract: The present invention provides an optically active compound represented by the following general formula (1), a photoreactive chiral agent, a liquid crystal composition, a liquid crystal color filter, an optical film, and a recording medium which include the optically active compound. wherein, Ra and Rb each independently denotes a hydrogen atom, an alkyl group, an aryl group, a heterocyclic group, an alkenyl group, or an alkynyl group, Rc and Rd each independently denotes a hydrogen atom, an alkyl group, or an alkoxycarbonyl group, and L denotes a divalent group and a binaphtyl portion has an axial asymmetry of either (R) or (S).Type: GrantFiled: December 13, 2001Date of Patent: August 26, 2003Assignee: Fuji Photo Film Co., Ltd.Inventors: Masatoshi Yumoto, Keiichiro Hayashi, Mitsuyoshi Ichihashi
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Publication number: 20030158426Abstract: The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula (1), where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon atoms from 4-hydroxy-6-X-substituted-methyl-tetrahydropyran-2-one compounds, where X is as defined above, with the aid of an acetalization agent, in the presence of an acid catalyst. The invention also relates to the novel compounds of formula (1) as well as salts and acids to be prepared from these, with the OR3 group in formula (1) being replaced by an OY group, where X, R1 and R2 have the meanings defined above and where Y stands for an alkaline (earth) metal or a substituted or unsubstituted ammonium group or stands for hydrogen, and to the novel compounds of formula (2). The products concerned are, after conversion into the t-butyl ester of 2-(6-hydroxymethyl-1,3-dioxane-4-yl)acetic acid, important as intermediary products in the preparation of statins.Type: ApplicationFiled: January 17, 2003Publication date: August 21, 2003Inventors: Jacob Hermanus Mattheus Hero Kooistra, Hubertus Josephus Marie Zeegers, Daniel Mink, Joannes Maria Cornelis Antonius Mulders
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Publication number: 20030158427Abstract: A process for preparing compounds of the formula I 1Type: ApplicationFiled: January 6, 2003Publication date: August 21, 2003Inventors: Hansgeorg Ernst, Klaus Henrich
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Patent number: 6528538Abstract: The present invention relates to cyclic compounds which are of the class of compounds of formula I wherein X and Y represent an oxygen atom and to processes for preparing such compounds. The compounds are useful in the treatment of dyslipidemia, atherosclerosis, and diabetes.Type: GrantFiled: January 16, 2001Date of Patent: March 4, 2003Assignee: Merck PatentgesellschaftInventors: Jean-Jacques Zeiller, Jean-Jacques Berthelon, Eric Raspé, Daniel Guerrier
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Publication number: 20030040634Abstract: This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions.Type: ApplicationFiled: September 13, 2002Publication date: February 27, 2003Inventors: Noriyuki Kizaki, Yukio Yamada, Yoshihiko Yasohara, Akira Nishiyama, Makoto Miyazaki, Masaru Mitsuda, Takeshi Kondo, Noboru Ueyama, Kenji Inoue
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Patent number: 6515149Abstract: Acetal compounds in which a 5- or 6-membered ring acetal structure is connected to a norbornene structure through a linker represented by —(CH2)m— in which one hydrogen atom may be substituted with a hydroxyl or acetoxy group, and m is from 1 to 8 are novel. Using the acetal compounds as a monomer, polymers are obtained. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation and has excellent sensitivity, resolution, and etching resistance.Type: GrantFiled: August 7, 2001Date of Patent: February 4, 2003Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeru Watanabe, Takeshi Kinsho, Koji Hasegawa, Tsunehiro Nishi, Mutsuo Nakashima, Seiichiro Tachibana, Jun Hatakeyama
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Publication number: 20030018199Abstract: A process is provided for preparing chiral diol sulfones of the structure 1Type: ApplicationFiled: May 30, 2002Publication date: January 23, 2003Inventors: Paul R. Brodfuehrer, Thomas R. Sattelberg, Joydeep Kant, Xinhua Qian
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Patent number: 6472544Abstract: This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions. A process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprises reacting an acetic acid derivative at a temperature of not less than −30° C.Type: GrantFiled: August 16, 2000Date of Patent: October 29, 2002Assignee: Kaneka CorporationInventors: Noriyuki Kizaki, Yukio Yamada, Yoshihiko Yasohara, Akira Nishiyama, Makoto Miyazaki, Masaru Mitsuda, Takeshi Kondo, Noboru Ueyama, Kenji Inoue
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Publication number: 20020143130Abstract: Disclosed are a monomer, a polymer for a photoresist, a photoresist composition and a phosphor layer for a cathode ray tube.Type: ApplicationFiled: February 14, 2002Publication date: October 3, 2002Inventors: Beom-Wook Lee, Ik-Chul Lim, Seung-Joon Yoo
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Publication number: 20020052515Abstract: Provided are a novel ammonium (3R,5S)-3,5,6-trihydroxyhexanoate derivative represented by the following formula (I): 1Type: ApplicationFiled: August 16, 2001Publication date: May 2, 2002Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Kenzo Sumi, Toshiyuki Murayama, Yoshiharu Gonda, Hideki Nara, Takashi Moroi
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Publication number: 20020049342Abstract: Substituted alkylketo compounds of the formula 1Type: ApplicationFiled: May 3, 2001Publication date: April 25, 2002Inventors: Ronald L. Hanson, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, John J. Venit
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Publication number: 20020015804Abstract: There can be provided a liquid crystalline compound expressed by the general formula (1): 1Type: ApplicationFiled: July 22, 1999Publication date: February 7, 2002Inventors: YASUHIRO HASEBA, SHUICHI MATSUI, KAZUTOSHI MIYAZAWA, NORIHISA HACHIYA, ETSUO NAKAGAWA
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Patent number: 6344569Abstract: The present invention provides a process which can produce an important intermediate for the production of the HMG coenzyme A reductase inhibitor atrovastatin, 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives, with ease industrially and in good yields, wherein a 3,5-dihydroxy-6-halohexanoic acid derivative is used as the starting material, and which comprises cyanation by reaction with a cyanating agent for substitution of a cyano group for the halogen atom and an acetal formation reaction of the diol moiety with an acetal forming reagent in the presence of an acid catalyst.Type: GrantFiled: January 2, 2001Date of Patent: February 5, 2002Assignee: Kaneka CorporationInventors: Masaru Mitsuda, Makoto Miyazaki, Kenji Inoue
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Patent number: 6331641Abstract: This invention provides an easy and efficient process for producing a simvastatin of great use as an HMG-CoA reductase inhibitor, which comprises deacylation of lovastatin with an inorganic base and a secondary or tertiary alcohol and subjecting the resulting diol lactone to selective protection with a ketal or acetal protective group, acylation and deprotection-lactonization to give simvastatin.Type: GrantFiled: September 28, 2000Date of Patent: December 18, 2001Assignee: Kaneka CorporationInventors: Naoaki Taoka, Kenji Inoue
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Patent number: 6268488Abstract: The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.Type: GrantFiled: May 25, 1999Date of Patent: July 31, 2001Inventors: Carlos F. Barbas, III, Doron Shabat, Christoph Rader, Benjamin List, Richard A. Lerner
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Patent number: 6184376Abstract: Methods and novel intermediates of the formula: wherein R6 and R7 are lower alkyl or benzyl or R6 and R7 taken together are —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2CH2—, R8 is C1-C21 alkyl or a C2-C21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy C1-C6 alkyl, C1-C6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 6, 1998Date of Patent: February 6, 2001Assignee: Mediver ABInventors: M. Robert Leanna, Steven M. Hannick, Michael Rasmussen, Jien-Heh J. Tien, Lakshmi Bhagavatula, Pulla Reddy Singam, Bradley D. Gates, Lawrence Kolaczkowski, Ramesh R. Patel, Greg Wayne, Greg Lannoye, Weijiang Zhang, Zhenping Tian, Kirill A. Lukin, Bikshandarkoil A. Narayanan, David A. Riley, Howard Morton, Sou-Jen Chang, Cynthia B. Curty, Daniel Plata, John Bellettini, Bhadra Shelat, Tiffany Spitz, Cheng-Xi Yang
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Patent number: 6156905Abstract: The invention relates to a process for the production of epothilones and intermediate products within the process.Epothilones A and B are natural substances, which can be produced by microorganisms, and the taxols have similar properties and are thus of particular interest in pharmaceutical chemistry.Type: GrantFiled: January 6, 2000Date of Patent: December 5, 2000Assignee: Novartis AGInventors: Dieter Schinzer, Anja Limberg, Oliver M. Bohm, Armin Bauer, Martin Cordes
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Patent number: 6057458Abstract: The present invention provides a process for producing an optically active aldehyde which comprises hydroformylating a terminal olefin substrate represented by the formula:Q.sub.1 Q.sub.2 C.dbd.CH.sub.2wherein Q.sub.1 is an atom or group other than carbon or hydrogen and Q.sub.2 is an atom or group other than hydrogen, in the presence of CO, H.sub.2 and a catalyst, which catalyst comprises a transition metal based compound and a ligand.Type: GrantFiled: November 12, 1997Date of Patent: May 2, 2000Assignee: The Trustees of Columbia University in the City of New YorkInventors: James L. Leighton, Deidre N. O'Neil
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Patent number: 6022938Abstract: Isocyanato compounds with capped, isocyanate-reactive groups are those of the formula I ##STR1## where R.sup.1 and R.sup.2 are hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.6 -C.sub.10 -aryl or C.sub.7 -C.sub.10 -aralkyl or together form C.sub.3 -C.sub.10 -alkanediyl,X and Y are --O--, --S-- or ##STR2## where R.sup.4 is hydrogen, C.sub.1 -C.sub.20 -alkyl which is uninterrupted or interrupted by oxygen atoms in ether function, or is C.sub.6 -C.sub.10 -aryl or C.sub.7 -C.sub.10 -aralkyl,R.sup.3 is C.sub.1 -C.sub.10 -alkanediyl which together with --X--CR.sup.1 R.sup.2 --Y-- forms a 4-7-membered ring,in which either one hydrogen in R.sup.3 or the radical R.sup.4 in ##STR3## is replaced by an allophanate group R.sup.Ia ##STR4## in which R.sup.5 is a divalent aliphatic, alicyclic, araliphatic or aromatic C.sub.2 -C.sub.20 hydrocarbon unit,R.sup.6 is a single bond or a divalent aliphatic, alicyclic, araliphatic or aromatic C.sub.1 -C.sub.20 hydrocarbon unit or a mono- or poly(C.sub.2 -C.sub.Type: GrantFiled: June 18, 1998Date of Patent: February 8, 2000Assignee: Basf AktiengesellschaftInventors: Bernd Bruchmann, Hans Renz, Gunter Mohrhardt
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Patent number: 5877332Abstract: New adducts are produced from the reaction of vinyl dioxo compounds with anhydrides, epoxyesters, lactones, and lactams, and such adducts are useful for preparing curable coating compositions.Type: GrantFiled: October 18, 1996Date of Patent: March 2, 1999Assignee: E. I. du Pont de Nemours and CompanyInventors: Basil Volodymr Gregorovich, Isidor Hazan, Hisanori Omura
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Patent number: 5824484Abstract: The invention provides a method of screening a substance for the ability to effect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the presence of homodimer formation. Also provided is a method of screening a substance for an effect on a retinoid X receptor homodimer's ability to bind DNA comprising combining the substance with the homodimer and determining the effect of the compound on the homodimer's ability to bind DNA. A method of inhibiting an activity of a retinoid X receptor heterodimer comprising increasing the formation of a retinoid X receptor homodimer, thereby preventing the retinoid X receptor from forming a heterodimer and preventing the resulting heterodimer activity is also provided. A method of inhibiting an activity of a retinoid X receptor homodimer is also provided.Type: GrantFiled: January 22, 1996Date of Patent: October 20, 1998Assignee: La Jolla Cancer Research FoundationInventors: Magnus Pfahl, Xiao-kun Zhang, Jurgen M. Lehmann, Marcia I. Dawson, James F. Cameron, Peter D. Hobbs, Ling Jong
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Patent number: 5739374Abstract: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.Type: GrantFiled: February 14, 1997Date of Patent: April 14, 1998Assignee: BASF AktiengesellschaftInventors: Bernd Janssen, Hans-Heiner Wuest
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Patent number: 5677432Abstract: A compound useful for forming immunoconjugates used in the detection of organophosphate pesticides is provided. The compound has the formula ##STR1## wherein X is selected from the group consisting of R--O--, R--S-- and R--NH--, where R is an optionally substituted aromatic or heterocyclic group, or an optionally substituted alkyl or alkenyl group;Y is O or S;R.sup.1 is H or alkyl; andR.sup.2 is a group of the formula --(CH.sub.2).sub.n -- wherein n is an integer of from 1 to 10, or branched chain alkylene, or a group of the formula R.sup.3 --O--R.sup.4 wherein R.sup.3 and R.sup.4 are both or straight or branched chain alkylene;or a salt or ester thereof.Type: GrantFiled: August 19, 1994Date of Patent: October 14, 1997Assignee: The Horticulture and Food Research Institute of New Zealand LimitedInventors: William Thomas Jones, Hans Wynberg, Wolter Ten Hoeve
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Patent number: 5656619Abstract: Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.Type: GrantFiled: June 6, 1995Date of Patent: August 12, 1997Assignee: BASF AktiengesellschaftInventors: Bernd Janssen, Hans-Heiner Wuest
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Patent number: 5606079Abstract: A process for producing 1,4-butanedial monoacetal by reacting acrolein acetal with a synthesis gas containing carbon monoxide and hydrogen, in the presence of a rhodium catalyst and an accelerator of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each, independently, denote a hydrogen atom, a C.sub.1 -C.sub.20 alkyl group or a C.sub.6 -C.sub.20 aryl group, or R.sup.1 and R.sup.2 together form a --(CH.sub.2).sub.n -- group, n is an integer of from 2 to 7, R.sup.3 and R.sup.4 each, independently, denote halogen or a trifluoromethyl group, and p and q are each, independently, an integer of from 0 to 3, which process can also be extended to the hydroformylation of other compounds which contain an olefin group in a terminal position.Type: GrantFiled: May 30, 1995Date of Patent: February 25, 1997Assignee: Mitsubishi Chemical CorporationInventors: Shuji Ichikawa, Akiko Fujita, Naoko Sumitani, Yuji Ohgomori
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Patent number: 5594153Abstract: A novel, overall process for the preparation of a compound of the formula I: ##STR1## where R.sup.1 and R.sup.2 are each independently hydrogen, an alkyl group, a cycloalkyl group, an aryl group or, taken together with the carbon atom to which they are attached, form a cycloalkyl group; andR.sup.3 is hydrogen, an alkyl group, or an aryl group, or salts thereof, useful as intermediates in the preparation of HMG-CoA reductase inhibitors; novel methods within the overall process; and novel intermediates produced by those methods.Type: GrantFiled: July 5, 1995Date of Patent: January 14, 1997Assignee: E. R. Squibb & Sons, Inc.Inventors: John K. Thottathil, Yadagiri Pendri, Wen-Sen Li, David R. Kronenthal
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Patent number: 5576449Abstract: The preparation of 2-substituted but-2-ene-1,4-dial-4-acetals of the formula I ##STR1## in which the substituents R.sup.1 to R.sup.4 stand for hydrogen or C.sub.1 -C.sub.6 aliphatic radicals, and R.sup.2 and R.sup.3 or R.sup.1 and R.sup.2 are in each case common members of an aliphatic 4-membered to 7-membered ring, which can contain a hetero atom, and R.sup.Type: GrantFiled: September 29, 1994Date of Patent: November 19, 1996Assignee: BASF AktiengesellschaftInventors: J urgen Frank, Johann-Peter Melder, Franz Merger, Tom Witzel
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Patent number: 5565583Abstract: Hemiacetals of glyoxal monoacetals are useful as intermediates to prepare 2-substituted but-2-en-1,4-dial-4-acetals of the general formula I; ##STR1##Type: GrantFiled: June 5, 1995Date of Patent: October 15, 1996Assignee: BASF AktiengesellschaftInventors: J urgen Frank, Johann-Peter Melder, Franz Merger, Tom Witzel
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Patent number: 5527800Abstract: A novel compound of the formula: ##STR1## wherein Ar represents an optionally substituted tricyclic condensed benzene ring group which includes at least one heterocyclic ring as a component ring; n represents an integer from 2 to 10; R.sup.1 represents H or an optionally substituted hydrocarbon group, which may be different from one another in the repetition of n; and Y represents an optionally substituted 4-piperidinyl, 1-piperazinyl or 4-benzyl-1-piperidinyl group, or a salt thereof, inhibiting excellent cholinesterase inhibitory activity and monoamine reuptake inhibitory activity, thus being useful as therapeutic and/or prophylactic medicaments of senile dementia.Type: GrantFiled: January 18, 1994Date of Patent: June 18, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Giichi Goto, Yuji Ishihara, Keisuke Hirai
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Patent number: 5510488Abstract: An improved process for the preparation of trans-6- 2-(substituted-pyrrole-1-yl)alkyl!pyran-2-ones by a novel synthesis is described where .alpha.-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N, 4-diphenyl-1- 2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl!-1H-pyrrol e-3-carboxamide, as well as other valuable intermediates used in the processes and prodrugs which are bioconverted to hypolipidemic and hypocholesterolemic agents and pharmaceutical compositions of the same.Type: GrantFiled: May 15, 1995Date of Patent: April 23, 1996Assignee: Warner-Lambert CompanyInventors: Donald E. Butler, Tung Van Le, Thomas N. Nanninga
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Patent number: 5481009Abstract: Methods of producing carboxylic acid ester derivatives of formulae (I) and (II), which are useful, for instance, as intermediates for producing an anti-hypercholesterolemic agent having an inhibitory effect on HMG-CoA Reductase: ##STR1## wherein R.sup.1 and R.sup.2 are independently a protective group for hydroxyl group, or R.sup.1 and R.sup.2 integrally constitute a protective group for hydroxyl groups; R.sup.3 is an alkyl group, or an aryl group; and R.sup.4 is a substituted aryl group, a substituted heterocyclic group, a substituted vinyl group, or a substituted cycloalkenyl group; and ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are respectively the same as defined in the above formula (I), are disclosed. In addition, intermediates for use in these methods of producing the carboxylic acid ester derivatives are disclosed.Type: GrantFiled: August 9, 1994Date of Patent: January 2, 1996Assignee: Fujirebio Inc.Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Eiko Mori, Hisako Kobayashi, Hiroshi Ikawa
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Patent number: 5449793Abstract: A novel optically active erythro-1-alkanoyloxy-2,4-O-isopropylidene-2,4-dihydroxy-5-substituted pentane expressed by the formula ##STR1## wherein R.sup.1 represents a halogen atom or cyano group and R.sup.2 represents an alkyl group of 1 to 6 carbon atoms, and a process for producing the above compound are provided, the compound being preferably usable as an intermediate for preparing a HMG-CoA reductase inhibitor and the process being practiced under mild conditions and with a high yield.Type: GrantFiled: May 12, 1994Date of Patent: September 12, 1995Assignee: Chisso CorporationInventors: Kazutoshi Miyazawa, Teruyo Sugiura, Yasuyuki Koizumi, Naoyuki Yoshida
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Patent number: 5399722Abstract: A novel process is described for preparing tert-butyl (3R, 5S ) 6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate of the formula I ##STR1## which is a valuable structural element for preparing inhibitors of HMG-CoA reductase.Type: GrantFiled: June 30, 1993Date of Patent: March 21, 1995Assignee: Hoechst AktiengesellschaftInventors: Gerhard Beck, Joachim-Heiner Jendralla, Kurt Kesseler
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Patent number: 5329018Abstract: A novel optically active erythro-1-alkanoyloxy-2,4-O-isopropylidene-2,4-dihydroxy-5-substituted pentane expressed by the formula ##STR1## wherein R.sup.1 represents a halogen atom or cyano group and R.sup.2 represents an alkyl group of 1 to 6 carbon atoms, and a process for producing the above compound are provided, the compound being preferably usable as an intermediate for preparing a HMG-CoA reductase inhibitor and the process being practiced under mild conditions and with a high yield.Type: GrantFiled: June 4, 1993Date of Patent: July 12, 1994Assignee: Chisso CorporationInventors: Kazutoshi Miyazawa, Teruyo Sugiura, Yasuyuki Koizumi, Naoyuki Yoshida
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Patent number: 5298632Abstract: Herbicidal pyrimidine compound having the formula ##STR1## wherein the substitutents A, R.sup.1, R.sup.2, X, Y.sup.1, Y.sup.2, Y.sup.3 and Z are as herein below defined.Type: GrantFiled: October 30, 1992Date of Patent: March 29, 1994Assignee: Sumitomo Chemical Company, LimitedInventors: Mitsunori Hiratsuka, Naonori Hirata, Kazuo Saitoh, Hideyuki Shibata
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Patent number: 5275757Abstract: Novel anti-ferroelectric liquid crystal compounds represented by the following general formula (I) and a liquid crystal display element wherein such a compound is used. ##STR1## Ph represents a phenylene group, R represents a straight-chain alkyl group having 6 to 10 carbon atoms,X represents an oxygen atom or a single bond provided that when X is an oxygen atom, L is an integer of 5 to 8, m is 1 and n is an integer of 1 to 7, or L and m are zero (0) and n is an integer of 6 to 8, and when X is a single bond,L is an integer of 5 to 8, m is 1 and n is an integer of 1 to 7, andC* represents an asymmetric carbon atom.Type: GrantFiled: December 4, 1992Date of Patent: January 4, 1994Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Hiroshi Mineta, Tomoyuki Yui, Takahiro Matsumoto
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Patent number: 5258477Abstract: Various novel acetal- and aldehyde-containing monomers are prepared. They can be polymerized and copolymerized by conventional polymerization techniques. The polymers contain repeating units derived from one or more ethylenically or allylically unsaturated monomers containing an acetal group or aldehyde group and optionally one or more repeating units derived from ethylenically or allylically unsaturated monomers other than the acetal-containing or aldehyde-containing monomer such as ethylene, vinyl acetate, ethyl acrylate, butyl acrylate, 2-ethylhexyl acrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, methyl methacrylate or acrylic acid. Aqueous emulsions of polymers containing the acetal-containing monomers and a hydroxy-containing monomer are useful as binders for nonwoven fabrics.Type: GrantFiled: October 16, 1990Date of Patent: November 2, 1993Assignee: National Starch and Chemical Investment Holding CorporationInventors: John J. Tsai, Patrick G. Jobe, Robert L. Billmers, Rama S. Chandran, Paul R. Mudge, Michael T. Sarkis