The Tricyclo Ring System Consists Of Three Six-membered Cyclos (e.g., Xanthene, Etc.) Patents (Class 549/388)
  • Patent number: 9023138
    Abstract: There is provided a compound represented by the following Formula (3): wherein in Formula (3), R201, R202 and R203 each independently represent a monovalent substituent, n201 and n202 each independently represent a number of 0 to 4, and n203 represents a number of 0 to 4, when n201, n202 and n203 each represent a number of 2 or more, a plurality of R201's, R202's and R203's may be the same or different, M represents a hydrogen atom or a counter cation, and M's may be the same or different, and a coloring composition containing the compound.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: May 5, 2015
    Assignee: FUJIFILM Corporation
    Inventors: Yoshihiko Fujie, Clive Edwin Foster, Keiichi Tateishi
  • Patent number: 9023139
    Abstract: There is provided a coloring composition including the compound represented by Formula (1) described in the specification and the compound selected from (A) to (C) described in the specification.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: May 5, 2015
    Assignee: FUJIFILM Corporation
    Inventors: Yoshihiko Fujie, Keiichi Tateishi, Clive Edwin Foster
  • Publication number: 20150087620
    Abstract: The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, which has a superior peripheral blood lymphocyte decreasing action, and is useful for the treatment or prophylaxis of autoimmune diseases; prophylaxis or suppression of resistance or acute rejection or chronic rejection of transplantation of organ or tissue; treatment or prophylaxis of graft-versus-host (GvH) disease due to bone marrow transplantation; or treatment or prophylaxis of allergic diseases.
    Type: Application
    Filed: April 23, 2013
    Publication date: March 26, 2015
    Applicant: MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Maiko Hamada, Kaoru Tashiro, Hiroshi Sakashita, Masatoshi Kiuchi, Shuzo Takeda, Kunitomo Adachi
  • Patent number: 8981126
    Abstract: Phosphenium compounds with the general formula I: in which R1, R2, R3 and R4 are identical or different and represent a linear or branched C1-C6-alkyl radical, which can optionally be substituted, or R1 and R2 and/or R3 and R4 are bonded to one another with the formation of a ring, R5 and R6 stand for a saturated or unsaturated and linear or branched alkyl group, alkenyl group or aryl group, which can have suitable substituents, even heteroatoms as substituents, or a heteroatom-comprising hydrocarbon group, which can have suitable substituents, and the R5 and R6 radicals can form a ring which can be 4- to 20-membered, saturated or unsaturated and alicyclic or heteroalicyclic and can exhibit suitable substituents, X? represents an anion, a process for the preparation thereof, and also the use of these compounds in metal complexes which can be used as catalysts in organic synthesis, are claimed.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: March 17, 2015
    Assignee: Studiengesellshaft Kohle mbH
    Inventors: Manuel Alcarazo, Hans Bruns, Jekaterina Petuskova
  • Patent number: 8932869
    Abstract: Certain embodiments of the present invention relate to the preparation of microbeads that exhibit a “turn on” fluorescence response within seconds of exposure to an analyte vapor (e.g., a chemical warfare agent or a reactive stimulant). This sensing approach is modeled after the mechanism for inhibition of acetylcholinesterase enzyme activity, and utilizes a specific and irreversible reaction between phosphonyl halides and a fluorescent indicator. The present invention also relates to a sensor and a method for sensing an analyte through detection of changes in the fluorescing properties of the inventive microbeads.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: January 13, 2015
    Assignee: Trustees of Tufts College
    Inventors: David R. Walt, Sandra Bencic-Nagale
  • Publication number: 20150005514
    Abstract: Disclosed herein is single step process for the synthesis of 4-aryl substituted chromanes of compound of formula 2 comprising subjecting 3-aryloxy-1-phenylpropan-1-ol of formula 1 to gold(III) chloride-catalyzed intramolecular Friedel-Crafts reaction to obtain 4-aryl substituted chromanes. The invention further discloses novel 4-substituted Chromane compounds.
    Type: Application
    Filed: December 17, 2012
    Publication date: January 1, 2015
    Inventors: Vilasrao Chouthaiwale Pandurang, Ambadas Devalankar Dattatray, Arumugam Sudalai
  • Publication number: 20140357503
    Abstract: Disclosed embodiments concern an array for use in identifying or identifying and quantifying analytes in a sample using a macrocyclic sensor comprising a macrocyclic compound and a detectable moiety. The disclosed array may be used to discriminate among various analytes based on different features, such as post-translational modifications, isomeric post-translational modifications, and the peptide sequence around post-translational modifications. Also disclosed is a method for identifying analytes comprising a post-translational modification, as well as an enzymatic assay using the disclosed macrocyclic sensor.
    Type: Application
    Filed: June 11, 2014
    Publication date: December 4, 2014
    Applicant: UVic Industry Partnerships Inc.
    Inventors: Fraser Hof, Samuel Minaker, Kevin Daze, Sara Tabet, Manuel Ma
  • Publication number: 20140319097
    Abstract: A phenolic monomer used in the lithographic process for semiconductor fabrication, a polymer for preparing a resist under-layer comprising the same, and a resist under-layer composition comprising the same, are disclosed.
    Type: Application
    Filed: November 1, 2012
    Publication date: October 30, 2014
    Inventors: Jeong-Sik Kim, Jae-Woo Lee, Jae-Hyun Kim
  • Patent number: 8871799
    Abstract: Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: October 28, 2014
    Assignee: Kineta, Inc.
    Inventors: Shawn P. Iadonato, Kristin Bedard
  • Publication number: 20140243404
    Abstract: This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed.
    Type: Application
    Filed: September 13, 2011
    Publication date: August 28, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Scott Alan Snyder, Daniel S. Treitler, Alexandria P. Brucks, Andreas Gollner, Maria I. Chiriac, Nathan E. Wright, Jason J. Pflueger, Steven P. Breazzano
  • Patent number: 8754244
    Abstract: The present invention relates to new rhodamine compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: June 17, 2014
    Assignee: Illumina Cambridge Limited
    Inventors: Nikolai Nikolaevich Romanov, Xiaohai Liu
  • Patent number: 8735444
    Abstract: The present invention relates to novel fluorinated 3,6-diaminoxanthene compounds derived from the basic structural formula (I) and to their uses as photostable fluorescent dyes, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional microscopy, stimulated emission depletion (STED) reversible saturable optically linear fluorescent transitions (RESOLFT) microscopy, and fluorescence correlation spectroscopy. The claimed compounds are also useful as molecular probes in various spectroscopic applications.
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: May 27, 2014
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Stefan W. Hell, Vladimir N. Belov, Gyuzel Mitronova, Mariano Bossi, Gael Moneron, Christian A. Wurm, Stefan Jakobs, Christian Eggeling, Jakob Bierwagen, Lars Meyer
  • Patent number: 8709743
    Abstract: The invention relates in part to compounds that act as highly nitric oxide (NO)-specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: April 29, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Lindsey E. McQuade, Evgeny A. Nudler
  • Patent number: 8686016
    Abstract: Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for the neurofibromatosis type 1 gene, the method comprising administering to a subject in need thereof an effective amount of a schweinfurthin or schweinfurthin analog or derivative, or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Also disclosed is a new schweinfurthin compound of the formula.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: April 1, 2014
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Iowa Research Foundation
    Inventors: Karlyne Reilly, Thomas Turbyville, John A. Beutler, David Wiemer
  • Publication number: 20140051870
    Abstract: Phosphenium compounds with the general formula I: in which R1, R2, R3 and R4 are identical or different and represent a linear or branched C1-C6-alkyl radical, which can optionally be substituted, or R1 and R2 and/or R3 and R4 are bonded to one another with the formation of a ring, R5 and R6 stand for a saturated or unsaturated and linear or branched alkyl group, alkenyl group or aryl group, which can have suitable substituents, even heteroatoms as substituents, or a heteroatom-comprising hydrocarbon group, which can have suitable substituents, and the R5 and R6 radicals can form a ring which can be 4- to 20-membered, saturated or unsaturated and alicyclic or heteroalicyclic and can exhibit suitable substituents, X? represents an anion, a process for the preparation thereof, and also the use of these compounds in metal complexes which can be used as catalysts in organic synthesis, are claimed.
    Type: Application
    Filed: February 23, 2012
    Publication date: February 20, 2014
    Inventors: Manuel Alcarazo, Hans Bruns, Jekaterina Petuskova
  • Patent number: 8637685
    Abstract: The invention provides fluorescent schweinfurthin analogs of formula (I) which are useful as probes and for the treatment of cancer and other diseases.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: January 28, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: David F. Wiemer, Jeffrey D. Neighbors, Raymond J. Hohl, Craig Kuder
  • Publication number: 20130323851
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Application
    Filed: August 8, 2013
    Publication date: December 5, 2013
    Applicant: ATTO-TEC GmbH
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Kemnitzer, Alexander Zilles
  • Patent number: 8530679
    Abstract: The present invention provides a process for handling ?9-THC, which comprises preparing a solution of ?9-THC in a solvent which exists as a gas at room temperature and atmospheric pressure. The invention also provides solutions of ?9-THC in the solvent and solid preparations of ?9-THC.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: September 10, 2013
    Assignee: Resolution Chemicals Limited
    Inventors: Parveen Bhatarah, Alan Kenneth Greenwood, Derek McHattie, Jerome Thomas Garfield Carr-Brion
  • Patent number: 8500807
    Abstract: The invention relates to an intraocular lens comprising at least one pharmaceutically-acceptable photochromic polymer that enables all or part of the intraocular lens to change colour reversibly when exposed to light.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: August 6, 2013
    Assignee: Carl Zeiss Meditec SAS
    Inventors: Pascal Bernard, Marc Dolatkhani, Anne Pagnoux, Christophe Hupin
  • Publication number: 20130137763
    Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
    Type: Application
    Filed: April 26, 2011
    Publication date: May 30, 2013
    Inventors: Floris Louis van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
  • Publication number: 20130108568
    Abstract: The invention relates to compound of generic formula (I) in which: R1 and R2 represent: OH, a hydrogen atom, a C1-C6 alkyl radical a C1-C6 alkoxy radical, a halogen, or OCOR3; R3 represents: a C1-C24 alkyl radical a C12-C24 alkenyl radical comprising at least one unsaturation; R4 represents: COR5, a glucide substituted or not by one or more acetyl radical(s); R5 represents: a C10-C24 alkyl radical or a C12-C24 alkenyl radical comprising at least one unsaturation; R6 and R7 represent:—simultaneously a hydrogen atom or a methyl radical, or—when R6 represents a hydrogen atom, R7 represents a C1-C6 alkyl radical or a phenyl substituted or not by one or more C1-C3 alkoxy radical(s) or one or more halogen(s) or—R6 and R7 are bonded together and form a C3-C6 cycloalkyl, and pharmaceutically or cosmetically acceptable salts.
    Type: Application
    Filed: July 8, 2011
    Publication date: May 2, 2013
    Applicant: PIERRE FABRE DERMO-COSMETIQUE
    Inventors: Stéphane Poigny, Françoise Belaubre
  • Patent number: 8389568
    Abstract: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: March 5, 2013
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, William P. Malachowski, Alexander J. Muller
  • Patent number: 8383841
    Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: February 26, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: Joe Y. L. Lam, Steven M. Menchen, Ruiming Zou, Scott C. Benson
  • Patent number: 8343269
    Abstract: The present invention is a colorant compound represented by the following general formula (1): wherein at least one of R2, R4, R7 and R9 is an acylamino group represented by the following general formula (2): wherein R11 denotes one of an alkyl group, a cycloalkyl group, an aryl group, an arylalkyl group, an alkenyl group and a heterocyclic group; and ‘*’ denotes a bonding site with an aromatic ring of the general formula (1).
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: January 1, 2013
    Assignee: Canon Kabushiki Kaisha
    Inventors: Kaoru Takahashi, Yasuaki Murai, Kei Inoue, Masashi Hirose, Takeshi Miyazaki, Ryosuke Nagao, Otome Mori, Minako Kawabe
  • Patent number: 8323750
    Abstract: The present invention relates to a UV irradiation assisted method of surface modification, which comprises: introducing a functional group L onto the surface of a polymer material P through the photochemical reaction of a photosensitive group X under UV irradiation, wherein the photosensitive group X comprises at least one xanthone unit.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: December 4, 2012
    Assignees: Beijing Wanhexinyuan BioTechnology Co., Ltd., Beijing University of Chemical Technology
    Inventors: Wantai Yang, Zhenhua Huang, Yanhe Tong, Lei Shao
  • Patent number: 8318699
    Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: November 27, 2012
    Assignees: The Trustees Of The University Of Pennsylvania, Cephalon, Inc.
    Inventors: Mark I Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiao
  • Patent number: 8308995
    Abstract: A chromene compound represented by the following formula (1): wherein R1, R2, R3, R4, R5, R6, m, and n are defined in the specification. The chromene compound is rarely deteriorated by exposure.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: November 13, 2012
    Assignee: Tokuyama Corporation
    Inventors: Soko Kasai, Shinobu Izumi
  • Patent number: 8303844
    Abstract: The present invention relates to benzo[f]chromene and pyrano[3,2-f]-chromene derivatives of the formula I in which L1, L2, R1, R2, A1, A2, Z1, Z2, m and n are as defined in claim 1, to the preparation thereof, to the use thereof as components in liquid-crystalline media, and to electro-optical display elements which contain the liquid-crystalline media according to the invention.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: November 6, 2012
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Axel Jansen, Melanie Klasen-Memmer
  • Publication number: 20120196295
    Abstract: Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted from the donor dye. One of the energy transfer dyes has a donor dye which is a member of a class of dyes having a coumarin or pyrene ring structure and an acceptor dye which is capable of absorbing energy emitted from the donor dye, wherein the donor dye has an absorption maxima between about 250 and 450 nm and the acceptor dye has an emission maxima at a wavelength greater than about 500 nm.
    Type: Application
    Filed: January 30, 2012
    Publication date: August 2, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventor: Linda G. Lee
  • Publication number: 20120164740
    Abstract: The present invention is a method to produce and to use a fluorogenic chemodosimeter for the detection of mercury ions in a sample at temperature ranges from about 0° C. to 100° C.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 28, 2012
    Inventors: Kazunori Koide, Shin Ando
  • Publication number: 20120138876
    Abstract: A chromene compound represented by the following formula (1): wherein R1, R2, R3, R4, R5, R6, m, and n are defined in the specification. The chromene compound is rarely deteriorated by exposure.
    Type: Application
    Filed: February 9, 2012
    Publication date: June 7, 2012
    Inventors: Soko KASAI, Shinobu Izumi
  • Patent number: 8178577
    Abstract: The present invention relates to certain tricyclic derivatives which are capable of inhibiting histone deacetylases. The compounds of this invention are therefore useful in treating diseases associated with abnormal histone deacetylase activities. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing these compounds are also disclosed.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: May 15, 2012
    Assignee: Shenzhen Chipscreen Biosciences Ltd.
    Inventors: Xian-Ping Lu, Zhi-Bin Li, Zhi-Qiang Ning
  • Publication number: 20120115723
    Abstract: A composition for treating waters, e.g. ballast water or injection water for oil recovery, to kill in-situ aquatic invasive species comprises at least one biocide capable of killing both animal and plant micro-organisms. The at least one biocide preferably comprises Brilliant Green, Gentian Violet, and/or erythrosine, and a wetting agent or detergent-like compound such as CTAB or CTAC. The invention also relates to a system for treating ballast water in situ comprising means for injecting a composition for treating ballast water; means for measuring the flow rate or amount of ballast water to be treated; means for controlling the dosing of the composition; and means for storing or receiving the composition. The invention also relates to a method of detecting viable aquatic organisms in ballast water in situ comprising detecting metabolism in viable micro-organisms in ballast water and, therefore, measuring the efficacy of any treatment.
    Type: Application
    Filed: January 29, 2010
    Publication date: May 10, 2012
    Applicant: UNIVERSITY OF STRATHCLYDE
    Inventors: William Stimson, Peilin Zhou, Dracos Vassalos, Atilla Incecik
  • Publication number: 20120095089
    Abstract: Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for the neurofibromatosis type 1 gene, the method comprising administering to a subject in need thereof an effective amount of a schweinfurthin or schweinfurthin analog or derivative, or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Also disclosed is a new schweinfurthin compound of the formula.
    Type: Application
    Filed: April 30, 2010
    Publication date: April 19, 2012
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Karlyne Reilly, Thomas Turbyville, John A. Beutler, David Wiemer
  • Patent number: 8158329
    Abstract: The present invention provides a compound represented by the formula (I): wherein P1, P2, P3, P4 and P5 each independently represents a hydrogen atom etc., and at least one selected from the group consisting of R1, R2, R3, R4, R5, R6, R7, R8 and R9 is the group represented by the formula (II): wherein X1 and X2 each independently represent a hydrogen atom etc., n represents an integer of 1 to 4, Z1 represents a C1-C6 alkyl group etc., and ring Y represents an alicyclic hydrocarbon group, and the others each independently represent a hydrogen atom, a C1-C6 alkyl group or a hydroxyl group, and a chemically amplified resist composition containing the same.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: April 17, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Ichiki Takemoto, Nobuo Ando
  • Patent number: 8143069
    Abstract: A compound represented by the following general formula (II): wherein R21 represents hydrogen atom or one to four monovalent substituents substituting on the benzene ring, and when R21 represents two or more substituents, the substituents may be the same or different; R22, R24, R25, and R27 independently represent hydrogen atom, or a monovalent substituent; R23 represents —OH or —N(R28)(R29) (wherein R28 and R29 independently represent an alkyl group which may be substituted); R26 represents —N(R30)(R31) (wherein R30 and R31 independently represent an alkyl group which may be substituted); n represents an integer of 1 to 3; and Y represents —S— or —O—, which is useful for selective measurement of hypochlorite ion.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: March 27, 2012
    Assignee: The University of Tokyo
    Inventors: Tetsuo Nagano, Yasuteru Urano, Suguru Kenmoku
  • Publication number: 20120009121
    Abstract: Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
    Type: Application
    Filed: March 19, 2010
    Publication date: January 12, 2012
    Applicant: The Johns Hopkins University
    Inventors: Martin Pomper, Ronnie Charles Mease, Ray Sangeeta, Ying Chen
  • Publication number: 20110319481
    Abstract: Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.
    Type: Application
    Filed: January 26, 2011
    Publication date: December 29, 2011
    Applicants: Government of the United States of America, National Institute of Health, University of Iowa Research Foundation
    Inventors: David F. Wiemer, Jeffrey D. Neighbors, John A. Beutler
  • Patent number: 8084627
    Abstract: Hydroxymethyl fluorescein derivatives are provided. The derivatives can be easily conjugated to other molecules, and are more permeable than other fluorescein derivatives. Methods of making the derivatives are also provided.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: December 27, 2011
    Assignee: University of Pittsburgh-of the Commonwealth System of Higher Education
    Inventors: Kazunori Koide, Amanda L. Garner, Fengling Song
  • Publication number: 20110270151
    Abstract: Disclosed are compositions and methods for targeted drug delivery using image-guided energy deposition to help localize active compounds to particular sites within the body of an animal. Also provided are compounds and formulations thereof for use in the targeted administration of therapeutically, prophylactically, and/or diagnostically effective amounts of such agents to a population of cells or tissues of a mammal in need thereof.
    Type: Application
    Filed: September 8, 2009
    Publication date: November 3, 2011
    Applicant: The Methodist Hospital Research Institute
    Inventor: King Chuen Li
  • Publication number: 20110229924
    Abstract: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.
    Type: Application
    Filed: March 2, 2011
    Publication date: September 22, 2011
    Inventors: Zhenjun Diwu, Jianjun He, Jinfang Liao
  • Publication number: 20110223677
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Application
    Filed: March 18, 2011
    Publication date: September 15, 2011
    Applicant: ATTO-TEC GmbH
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Këmnitzer, Alexander Zilles
  • Publication number: 20110213123
    Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
    Type: Application
    Filed: August 30, 2010
    Publication date: September 1, 2011
    Inventors: Carolyn R. Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin
  • Publication number: 20110201042
    Abstract: The invention relates in part to compounds that act as highly nitric oxide (NO)-specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS.
    Type: Application
    Filed: December 17, 2008
    Publication date: August 18, 2011
    Applicant: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Lindsey E. McQuade, Evgeny A. Nudler
  • Publication number: 20110165606
    Abstract: The present invention relates to methods and compositions for modifying, isolating, detecting, visualizing, and quantifying citrulline and/or homocitrulline-containing peptides, polypeptides, and proteins using mono- and disubstituted glyoxal derivatives. The invention also provides kits for modifying, isolating, detecting, visualizing, and quantifying the relative amounts of citrulline and/or homocitrulline-containing peptides, polypeptides, or proteins in solutions or samples.
    Type: Application
    Filed: June 12, 2008
    Publication date: July 7, 2011
    Inventors: Astrid E.V. Tutturen, Anders Holm, Burkhard Fleckenstein
  • Publication number: 20110117024
    Abstract: Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.
    Type: Application
    Filed: April 6, 2009
    Publication date: May 19, 2011
    Applicant: RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Hilliard Kutscher, Manjeet Deshmukh, Anupa Menjoge, Yashveer Singh, Simi Gunaseelan
  • Patent number: 7935822
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: May 3, 2011
    Assignee: ATTO-TEC GmbH
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Kemnitzer, Alexander Zilles
  • Publication number: 20110098441
    Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.
    Type: Application
    Filed: January 22, 2004
    Publication date: April 28, 2011
    Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.
    Inventors: Jannis G. Stavrianopoulos, Flazar Rabbani
  • Patent number: 7932014
    Abstract: A photosensitive compound has two or more structural units, in a molecule, represented by the following general formula (1): wherein R1 to R8 are selected from the group consisting of a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an acetoxy group, a phenyl group, a naphthyl group, and an alkyl group in which some or all of the hydrogen atoms are optionally replaced by fluorine atoms; R9 is a hydrogen atom or a hydroxyl group; X is a substituted or unsubstituted phenylene group or a substituted or unsubstituted naphthalene group; and Y is an oxygen atom or a single bond.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: April 26, 2011
    Assignee: Canon Kabushiki Kaisha
    Inventor: Toshiki Ito
  • Publication number: 20110067598
    Abstract: The present invention is a colorant compound represented by the following general formula (1): wherein at least one of R2, R4, R7 and R9 is an acylamino group represented by the following general formula (2): wherein R11 denotes one of an alkyl group, a cycloalkyl group, an aryl group, an arylalkyl group, an alkenyl group and a heterocyclic group; and ‘*’ denotes a bonding site with an aromatic ring of the general formula (1).
    Type: Application
    Filed: September 3, 2010
    Publication date: March 24, 2011
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Kaoru Takahashi, Yasuaki Murai, Kei Inoue, Masashi Hirose, Takeshi Miyazaki, Ryosuke Nagao, Otome Mori, Minako Kawabe