Bicyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/396)
  • Patent number: 4337337
    Abstract: The present invention provides 2,5-inter-o-phenylene-3,4-dinor-6,9.alpha.-epoxy-6.beta.-6-iodo-PGF.sub.1 compounds. These compounds are intermediates for preparing 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs, which are useful for pharmacological purposes, e.g., as antithrombotic agents.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: June 29, 1982
    Assignee: The Upjohn Company
    Inventors: Udo F. Axen, John C. Sih
  • Patent number: 4328240
    Abstract: 2-oxa-bicyclic prostaglandins are provided, together with methods for their preparation and pharmaceutical and veterinary compositions containing same. The compounds have a wide range of pharmacological utilities, such as hypotensive agents, vasodilatory agents, and anti-aggregating agents.
    Type: Grant
    Filed: July 28, 1978
    Date of Patent: May 4, 1982
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Patent number: 4328156
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-7.alpha.-homo-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: May 4, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih