Chalcogen Bonded Directly To The Carbocyclic Ring Of The Bicyclo Ring System (e.g., Tocopherols, Etc.) Patents (Class 549/408)
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Patent number: 8048913Abstract: A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.Type: GrantFiled: September 14, 2009Date of Patent: November 1, 2011Assignees: Australian Health & Nutrition Assoc. Ltd., Children's Hospital Medical CenterInventors: Kenneth David Reginald Setchell, Sidney John Cole
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Patent number: 8044097Abstract: The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondria) disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.Type: GrantFiled: February 26, 2009Date of Patent: October 25, 2011Assignee: Ampere Life Sciences, Inc.Inventors: Bing Wang, Jian Chen
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Publication number: 20110207749Abstract: The present disclosure is generally directed to compounds that can inhibit DAGL? and/or ? activity, compositions comprising such compounds, and methods for inhibiting DAGL? and/or ? activity.Type: ApplicationFiled: February 11, 2011Publication date: August 25, 2011Inventors: Louis S. Chupak, Xiaofan Zheng, Min Ding, Shuanghua Hu, Yazhong Huang, Robert G. Gentles
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Publication number: 20110201679Abstract: The present invention provides methods for elevating IKBKAP gene expression and the level of functional IKAP protein in cells, which are beneficial to human individual, such as an individual suffering from a neurodegenerative disease or disorder such as Familial Dysautonomia, by providing one or more tocotrienols alone or in combination with one or more tocopherols to the cells. The present invention also provides methods for treating neurodegenerative diseases or disorders by providing tocotrienols alone or in combination with one or more tocopherols to a patient having a neurodegenerative disease such as Alzheimer's disease, Huntington's disease, amylotrophic lateral sclerosis as well as age-related cognitive decline. Related therapeutic kits are also provided.Type: ApplicationFiled: January 14, 2011Publication date: August 18, 2011Inventors: Berish Y. Rubin, Sylvia L. Anderson
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Patent number: 7999004Abstract: The present invention provides compounds having estrogenic activity selected from the group consisting of RRR-?-tocopherol, hydro-Q9 chromene, coenzyme Q9, cycloartane, 1-Feruloyl glycerol, ?-tocopherol-9, and analogues thereof. The compounds of the present invention activate ER? and ER?, and express high estrogenic activity.Type: GrantFiled: February 9, 2007Date of Patent: August 16, 2011Assignee: National Taiwan UniversityInventors: Ching-jing Huang, Wei-Yi Cheng, Yueh-Hsiung Kuo, Yi-Ming Chiang
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Patent number: 7982036Abstract: The present invention provides compounds of formula I wherein Ring A, Ring B, m, Rx, Ry, W and R1 are as defined herein, pharmaceutically acceptable salts and compositions thereof, and methods of using the same.Type: GrantFiled: October 17, 2008Date of Patent: July 19, 2011Assignee: Avila Therapeutics, Inc.Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
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Publication number: 20110144358Abstract: The present invention is directed to a process for the manufacture of a 2,3,5-trimethylhydroquinone dialkanoate comprising reacting ketoisophorone with an acylating agent in the presence of an indium salt as the catalyst. Preferred are indium(III) salts such as indium trichloride or indium tris (trifluoromethanesulfonate). Further aspects of the present invention are a process for the manufacture of 2,3,5-trimethylhydroquinone using 2,3,5-trimethylhydroquinone dialkanoate as the starting material, especially a process for the manufacture of 2,3,5-trimethylhydroquinone by transesterification of 2,3,5-trimethylhydroquinone dialkanoate, as well as a process for the manufacture of a-tocopherol and its alkanoates, especially of (all-rac)-a-tocopherol and its acetate, comprising the reaction of ketoisophorone to 2,3,5-trimethylhydroquinone dialkanoate according to the present invention.Type: ApplicationFiled: February 18, 2011Publication date: June 16, 2011Applicant: DSM IP Assets B.V.Inventors: Werner Bonrath, Yann Foricher
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Patent number: 7960432Abstract: A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.Type: GrantFiled: July 3, 2008Date of Patent: June 14, 2011Assignees: Children's Hospital Medical Center, Australian Health & Nutrition Association LimitedInventors: Kenneth David Reginald Setchell, Sidney John Cole
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Publication number: 20110124832Abstract: Provided is a low-cost, environmentally friendly living radical polymerization catalyst having high activity. The catalyst is used for a living radical polymerization method, and contains a central element consisting of oxygen and at least one halogen atom bound to the central element. Furthermore, an alcohol compound can be used as a catalyst precursor. By polymerizing a monomer in the presence of the catalyst, a polymer having narrow molecular weight distribution can be obtained, and the cost of the living radical polymerization can be remarkably reduced. The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages of the catalyst such as low toxicity of the catalyst, low amount of the catalyst necessary, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor (which do not require a post-treatment for a molded article), and the like.Type: ApplicationFiled: February 6, 2009Publication date: May 26, 2011Applicant: KYOTO UNIVERSITYInventors: Atsushi Goto, Takeshi Fukuda, Yoshinobu Tsujii
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Publication number: 20110059898Abstract: This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In particular, the invention concerns pro-oxidant anti-cancer compounds, such as pro-oxidant forms of vitamin E, that selectively interact with complex II of the mitochondrial respiratory chain of cancerous cells, generate reactive oxygen species and induce apoptosis of those cells.Type: ApplicationFiled: September 17, 2007Publication date: March 10, 2011Inventors: Stephen John Ralph, Jiri Neuzil
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Publication number: 20110015412Abstract: The invention relates to a process of reacting a primary allylic alcohol with a compound containing a) a metal selected from the group consisting of Ag, Au, Ce, Mn, Ni, Ru, Re, Zn and Co preferably Ag and b) an oxidant like TEMPO (2,2?,6,6?-tetra-methylpiperidin-1-oxyl) or its derivates and c) a co-oxidants selected from the group of peroxodisulfates (PDS), H2505, H2O2, NaOCl, O2, KOCl, and air.Type: ApplicationFiled: February 15, 2008Publication date: January 20, 2011Applicant: DSM IP ASSETS B.V.Inventors: Werner Bonrath, Jean-Francois Eckhardt, Manfred L. Eggersdorfer, Ramona Hinze, Wolfgang F. Hölderich, Michael H. Valkenberg
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Publication number: 20100273871Abstract: Compounds of formula I: wherein X is selected from oxygen, nitrogen and sulfur; n is 0 or 1; R1 is selected from alkyl, carboxylic acid, carboxylate, carboxamide, ester and combinations thereof; R2 is selected from alkyl, substituted alkyl, carboxylic acid, carboxylate, carboxamide, sulfonyl, sulfonamide and combinations thereof; and derivatives and metabolites thereof. Further provided are methods of using a compound of formula I to prevent and/or treat a subject having a condition characterized by unwanted cell proliferation. Also provided are pharmaceutical compounds comprising one or more compounds of formula I, or derivatives or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: April 27, 2010Publication date: October 28, 2010Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Ching-Shih Chen, Dasheng Wang
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Publication number: 20100267673Abstract: Tocopheryl succinate derivatives according to formula I: are described. These compounds increase the activity of protein phosphatase 2A, can be included in pharmaceutical compositions, and can be used for the treatment of androgen receptor-dependent cancers such as prostate cancer.Type: ApplicationFiled: April 13, 2010Publication date: October 21, 2010Applicant: THE OHIO SATE UNIVERSITY RESEARCH FOUNDATIONInventors: Ching-Shih Chen, Dasheng Wang, Samuel K. Kulp
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Publication number: 20100267820Abstract: Vitamin E succinate derivatives according to formula I: are described. These compounds can be included in pharmaceutical compositions, and can be used for the treatment of cancers such as metastatic cancer and as antiadhesive agents.Type: ApplicationFiled: April 16, 2010Publication date: October 21, 2010Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Ching-Shih Chen, Dasheng Wang, Samuel K. Kulp
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Publication number: 20100152272Abstract: Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone moiety), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO—, where y is 2-4 or 6-24 and —(CH2CH2O)zCH2COO—, where z is 2-24; each Y is independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester moiety), —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety), —CO(CH2)mO—, where m is 2-4 or 6-24 and —COCH2O(CH2CH2O)n— where n is between 2-24; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.Type: ApplicationFiled: February 17, 2010Publication date: June 17, 2010Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S. Bezwada
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Patent number: 7718814Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R1 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: GrantFiled: October 30, 2007Date of Patent: May 18, 2010Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Publication number: 20100105930Abstract: The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.Type: ApplicationFiled: October 27, 2009Publication date: April 29, 2010Inventors: Kieron E. WESSON, Andrew W. Hinman, Orion D. Jankowski
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Publication number: 20100099786Abstract: The invention relates to a compound comprising (a) at least two polymerisable moieties, (b) at least one amino acid residue of an amino acid comprising at least two amine groups of which at least two amine groups have formed a carbamate, a thiocarbamate or a carbamide group, and (c) a biomolecular moiety linked directly or via a spacer to the carboxylic acid moiety of the diamino acid residue or a carboxylic acid to which such moiety can be linked. The invention further relates to a polymer obtainable from such compound.Type: ApplicationFiled: November 7, 2007Publication date: April 22, 2010Inventors: Aylvin Jorge Angelo Athanasius Dias, Bartholomeus Johannes Margretha Plum, Peter Jan Leonard Mario Quaedflieg, Roel Wim Wiertz
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Patent number: 7652155Abstract: The present invention relates to a compound represented by formula (1): (wherein, R1, R2, R3 and R4 respectively and independently represent a hydrogen atom or a C1-6 alkyl group, and n represents an integer of 1 or 2) and a production process thereof, as well as an antioxidant that contains the compound as its active ingredient, and a kidney disease treatment agent, cerebrovascular disorder treatment agent, retina oxidative disorder inhibitor and lipoxygenase inhibitor that contain the antioxidant.Type: GrantFiled: April 13, 2004Date of Patent: January 26, 2010Assignee: Nippon Soda Co., Ltd.Inventors: Nobuhiro Umeda, Nobuo Mochizuki, Seiichi Uchida, Seiichi Ikeyama
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Patent number: 7638648Abstract: Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.Type: GrantFiled: March 23, 2007Date of Patent: December 29, 2009Assignee: Allergan Inc.Inventors: Jayasree Vasudevan, Liming Wang, Xiaoxia Liu, Kwok Yin Tsang, Ling Li, Janet A. Takeuchi, Thong Vu, Richard Beard, Smita Bhat, Vidyasagar Vuligonda, Roshantha A. Chandraratna
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Patent number: 7626046Abstract: A process for the manufacture of (all-rac)-?-tocopherol comprises submitting isolated, purified phytyltrimethylhydroquinone to acid catalysis, thereby promoting ring closure to (all-rac)-?-t-tocopherol. The process can be conducted in the absence or presence of an added solvent, and when a solvent or solvent mixture is used the solvent or at least one solvent component of the solvent mixture is preferably one with a dipole moment greater than 9×10?30 C-m (or 2.7D). The nature of the catalyst is immaterial, but the catalyst is preferably sulphuric acid, phosphoric acid, a polyperfluoroalkylenesulphonic acid, a “NH-acid”, a heteropoly acid, zinc chloride, boron trifluoride, aluminium trichloride, or a mixture of any f the aforementioned Brönsted acids with any of the aforementioned Lewis acids. The product of the process is the most active an industrially most important member of the vitamin E group.Type: GrantFiled: October 23, 2002Date of Patent: December 1, 2009Assignee: DSM IP Assets B.V.Inventors: Werner Bonrath, David Carl Burdick, Frank Schager, Dominik Thomas, Thomas Netscher
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Patent number: 7615650Abstract: The invention provides a process for producing a chroman compound represented by formula (1), characterized in that the process includes allowing a phenol, an unsaturated compound, and a formaldehyde to react in the absence of catalyst and in the presence of water in an amount by mole 1 to 10 times that of the phenol. According to the present invention, a high-purity chroman compound can be produced in the absence of catalyst and under mild conditions. In addition, the invention provides an industrial means for producing the compound, without using a large amount of an acid or a base serving as a reaction promoter or a catalyst, which would otherwise cause side reactions, apparatus corrosion, etc.Type: GrantFiled: January 28, 2005Date of Patent: November 10, 2009Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Kazuo Tanaka, Youichi Kyuuko, Toshio Hidaka
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Publication number: 20090267026Abstract: A liquid crystal compound is to be obtained that has stability to heat, light and so forth, a high clearing point, a suitable optical anisotropy, a large negative dielectric anisotropy, and excellent compatibility with other liquid crystal compounds. A liquid crystal composition containing the compound is also to be obtained that has a low viscosity, a suitable optical anisotropy, a suitable negative dielectric anisotropy, a low threshold voltage, a high maximum temperature of a nematic phase (phase transition temperature from a nematic phase to an isotropic phase), and a low minimum temperature of a nematic phase. A compound having a hydrocoumarin skeleton is synthesized, and a liquid crystal composition containing the compound is produced.Type: ApplicationFiled: December 8, 2006Publication date: October 29, 2009Inventors: Mayumi Goto, Teruyo Sugiura, Norikatsu Hattori, Kouki Sagou
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Patent number: 7608638Abstract: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.Type: GrantFiled: October 22, 2007Date of Patent: October 27, 2009Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Daurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Patent number: 7585891Abstract: Certain novel (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula I: where R through R10, inclusively, x, A, B, y, D, E, G and M are fully described herein. Preferred compounds of the present invention are those wherein the benzofused ring moiety is attached to the remainder of the molecule at the positions designated as 1- or 2-. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.Type: GrantFiled: April 28, 2004Date of Patent: September 8, 2009Assignee: FMC CorporationInventors: George Theodoridis, Edward J. Barron, Dominic P. Suarez, Y. Larry Zhang, Ping Ding, John W. Lyga, Matthew P. Whiteside, Frank J. Zawacki
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Publication number: 20090214452Abstract: The invention is directed to a strategy for providing therapeutic or cosmetic benefit to skin by topically applying arginine chemically bound to a second (non-oligo arginine) compound in order to increase transepithelial delivery of arginine through a combination of increased solubility and flux across the skin. The arginine heteromers of the invention can add other complementary or beneficial properties for the skin beyond those that are arginine-related.Type: ApplicationFiled: December 28, 2006Publication date: August 27, 2009Inventor: Jacob M. Waugh
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Patent number: 7579014Abstract: The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have applications as drug-delivery vehicles.Type: GrantFiled: December 27, 2006Date of Patent: August 25, 2009Assignee: Board of Regents the University of Texas SystemInventors: Ying Ma, Kenneth J. Balkus, Jr.
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Publication number: 20090192179Abstract: The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondria) disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.Type: ApplicationFiled: February 26, 2009Publication date: July 30, 2009Inventors: Bing Wang, Jian Chen
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Patent number: 7547794Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: GrantFiled: March 25, 2004Date of Patent: June 16, 2009Assignee: Vertex Pharmaceuticals IncorporatedInventors: Jeremy Green, Alex Aronov, Albert C. Pierce
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Patent number: 7528267Abstract: A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained.Type: GrantFiled: August 1, 2005Date of Patent: May 5, 2009Assignees: Girindus America, Inc., Children's Hospital Medical CenterInventors: Kenneth David Reginald Setchell, Victor Dmitrievich Sorokin
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Publication number: 20090088467Abstract: The invention relates to a formulation for supplementation on immune response to a biological substance. More particularly, the formulation consists of one or more forms of Vitamin E which provides a supplementation on immune response to tetanus toxoid. In addition, the present invention also relates on the effect of different types of Vitamin E such as tocotrienol rich fraction, delta tocotrienol and alpha-tocopherol supplementation on immune response to tetanus toxoid vaccination.Type: ApplicationFiled: October 1, 2008Publication date: April 2, 2009Applicant: MALAYSIAN PALM OIL BOARD (MPOB)Inventor: Kalanithi NESARETNAM
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Publication number: 20080312458Abstract: The object of this invention was to probe the reactivity of lovastatin, simvastatin, pravastatin, and mevastatin in the solid-state without radical initiators in order to determine the antioxidant that provided the best stability for the statin. Phenolic antioxidants were evaluated.Type: ApplicationFiled: June 13, 2008Publication date: December 18, 2008Applicant: ABBOTT LABORATORIESInventor: Russell F. Lang
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Publication number: 20080293955Abstract: The present invention relates to a process for preparing adsorbates of at least one vitamin E compound in adsorbed form on a silica support, comprising, as the essential step, the mixing of the corresponding vitamin E compound with the silica support under reduced pressure. The invention further relates to adsorbates which are preparable by the process mentioned.Type: ApplicationFiled: December 11, 2006Publication date: November 27, 2008Applicant: BASF SEInventors: Robert Rühle, Dieter Feuerstein, Wolfram Strauch
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Patent number: 7429411Abstract: The compound (1) according to the invention has general solid-state properties necessary for a compound, stability against heat, light and the like, a suitable optical anisotropy, a suitable dielectric anisotropy, and excellent compatibility with other liquid crystalline compounds. The liquid crystal composition according to the invention contains at least one compound represented by formula (1). The liquid crystal display element according to the invention contains the composition. The compound (1) is represented by formula (1): wherein Ra, Rb, A1, A2, A3, A4, A5, A6, Z11, Z12, Z13, Z14, Z15, Z16, Y1, Y2, k, l, m, n, p and q are as defined in the specification.Type: GrantFiled: June 23, 2004Date of Patent: September 30, 2008Assignees: Chisso Petrochemical Corporation, Chisso CorporationInventors: Teruyo Sugiura, Makoto Ushioda
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Publication number: 20080193432Abstract: The present invention provides compounds having estrogenic activity selected from the group consisting of RRR-?-tocopherol, hydro-Q9 chromene, coenzyme Q9, cycloartane, 1-Feruloyl glycerol, ?-tocopherol-9, and analogues thereof. The compounds of the present invention activate ER? and ER?, and express high estrogenic activity.Type: ApplicationFiled: February 9, 2007Publication date: August 14, 2008Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Ching-jang Huang, Wei-Yi Cheng, Yueh-Hsiung Kuo, Yi-Ming Chiang
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Patent number: 7410998Abstract: Benzopyran-based inhibitors of NADH:ubiquinone oxidoreductase for inhibiting the growth of cancer cells.Type: GrantFiled: September 6, 2001Date of Patent: August 12, 2008Assignee: The Scripps Research InstituteInventors: Kyriacos C. Nicolaou, Jeffrey Pfefferkorn, Guo-Qiang Cao, Anthony Roecker
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Patent number: 7396855Abstract: A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.Type: GrantFiled: July 24, 2003Date of Patent: July 8, 2008Assignees: Children's Hospital Medical Center, Australian Health & Nutrition Assoc. Ltd.Inventors: Kenneth David Reginald Setchell, Sidney John Cole
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Publication number: 20080119514Abstract: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.Type: ApplicationFiled: October 22, 2007Publication date: May 22, 2008Inventors: Bob G. Sanders, Kimberly Kline, Daurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Publication number: 20080015354Abstract: The invention concerns a novel process for the preparation of 2H-chromenes of formula I and formula 5 and valuable intermediates of formulae 3 and 4 of this process.Type: ApplicationFiled: August 3, 2004Publication date: January 17, 2008Applicant: ARPIDA AGInventors: Jurgen Jaeger, Kaspar Burri, Soran Greiveldinger-Poenaru, Johannes Hoffner
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Patent number: 7312232Abstract: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound having said structural formula.Type: GrantFiled: August 20, 2003Date of Patent: December 25, 2007Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Laurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Patent number: 7309755Abstract: A method for making a polycarbonate article is described wherein the article is made by rotation molding a melt polycarbonate having a weight average molecular weight from 25,000 to about 36,000. The melt polycarbonate is produced by transesterifying a diaryl carbonate and a dihydroxy compound in the presence of a catalyst system to form an intermediate aromatic polycarbonate, wherein the catalyst system comprises a first catalyst selected from the group consisting of alkali metal salts and alkaline earth metal salts; and a second catalyst selected from the group consisting of quaternary ammonium compounds and quaternary phosphonium compounds; adding to said intermediate aromatic polycarbonate a catalyst quencher, and rotation molding the aromatic polycarbonate at a temperature from about 305° C. to about 360° C. Also disclosed are polycarbonate light diffusive articles produced by rotation molding.Type: GrantFiled: August 24, 2005Date of Patent: December 18, 2007Assignee: General Electric CompanyInventor: Johannes Martinus Dina Goossens
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Patent number: 7297715Abstract: A class of chromane and chromene compounds having the structure shown below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment and control of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, such as atherosclerosisType: GrantFiled: July 25, 2003Date of Patent: November 20, 2007Assignee: Merck & Co., Inc.Inventors: Ranjit C. Desai, Soumya Sahoo
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Patent number: 7247355Abstract: The present invention relates to a compound having a chroman ring, which has good thermal and optical stability, adequate optical anisotropy, adequate dielectric anisotropy and superior compatibility with other liquid crystal compounds, a liquid crystal composition comprising the compound, and a liquid crystal device comprising the composition.Type: GrantFiled: December 16, 2005Date of Patent: July 24, 2007Assignees: Chisso Corporation, Chisso Petrochemical CorporationInventors: Kouki Sagou, Atsuko Fujita
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Patent number: 7226644Abstract: The present invention relates to a liquid crystal compound which has negative dielectric anisotropy and a large absolute value thereof; and a liquid crystal display element which contains the compound as a constituent element and has a negative value of dielectric anisotropy in the vertical alignment mode, IPS, or the like. The liquid-crystal display element has a structure including a pair of substrates and a liquid crystal sandwiched therebetween, and includes at least an alignment control layer, a transparent electrode, and a polarizing plate, in which the liquid crystal includes at least one compound having a partial structure represented by general formula (A): (wherein W1 and W2 each independently represents fluorine, chlorine, —CF3, —CF2H, —OCF3, or —OCF2H) and has negative dielectric anistropy.Type: GrantFiled: June 25, 2004Date of Patent: June 5, 2007Assignee: Dainippon Ink and Chemicals, Inc.Inventors: Takashi Matsumoto, Tetsuo Kusumoto, Shotaro Kawakami
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Patent number: 7148240Abstract: The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular system.Type: GrantFiled: August 23, 2001Date of Patent: December 12, 2006Assignee: Sanofi-AventisInventors: Jean-Louis Assens, Claude Bernhart, Frédérique Cabanel-Haudricourt, Dino Nisato
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Patent number: 7138532Abstract: Processes for preparing color-stable, low-impurity tocopherol compositions are described, wherein the processes comprise: (a) providing a protecting group-substituted tocopherol compound, for example an acetate of a natural-source tocopherol compound; (b) purifying the protecting group-substituted tocopherol compound, for example through crystallization; and (c) solvolyzing the purified compound to form free tocopherol. Also described are the tocopherol compositions prepared thereby.Type: GrantFiled: July 24, 2003Date of Patent: November 21, 2006Assignee: Cognis CorporationInventor: Norman Milstein
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Patent number: 7115657Abstract: The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating ischemia-reperfusion injury, as well as a variety of disorders related to free radicals and/or arrhythmias. These bifunctional drugs should preferentially segregate in the membrane and produce their antiarrhytmic effects while, at the same time, help in protecting the membrane lipids by scavenging free radicals.Type: GrantFiled: July 4, 2001Date of Patent: October 3, 2006Assignee: Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.Inventors: Maria Koufaki, Theodora Calogeropoulou, Alexandros Makriyannis
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Patent number: 7105686Abstract: The present invention is concerned with a novel process for the manufacture of tocol, tocol derivatives and tocopherols, especially ?-tocopherol, by the reaction of a hydroquinone featuring 0 to 3 methyl groups, especially 2,3,5-trimethylhydroquinone, with isophytol, phytol or a(n) (iso)phytol derivative, most preferably with isophytol, in the presence of gadolinium trifluoromethanesulfonate, Gd(OSO2CF3)3, as the catalyst in a biphasic solvent system. This biphasic solvent system consists essentially of a polar organic solvent and a non-polar organic solvent. The polar organic solvent is preferably ethylene carbonate and/or propylene carbonate. The non-polar solvent is preferably at least a solvent selected from the group consisting of hexane, heptane, octane, cyclohexane and methylcyclohexane.Type: GrantFiled: August 11, 2004Date of Patent: September 12, 2006Assignee: DSM IP Assets B.V.Inventors: Lisa Giraudi, Werner Bonrath
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Patent number: 6987194Abstract: Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives of Formula I are disclosed. These compounds provide unexpected insecticidal activity across a spectrum of insect pests combined with desirable physical properties including improved photostability. wherein x and y are integers independently selected from 0 or 1; and B is a bridging group *—(CR16R17)q—(CR18R19)r—(CR20R21)s—Lt—(CR22R23)u—(CR24R25)v—(CR26R27)w—, where the asterisk denotes attachment at A; and q, r, s, u, v and w are integers independently selected from 0, 1 and 2; and t is an integer selected from 0 and 1. A, D, E, G, M, R through R11, and R16 through R27, inclusively, are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I and methods of controlling insects by applying said compositions to a locus where insects are present or are expected to be present are also disclosed.Type: GrantFiled: April 27, 2004Date of Patent: January 17, 2006Assignee: FMC CorporationInventors: George Theodoridis, Edward J. Barron, Dominic P. Suarez, Y. Larry Zhang, Ping Ding, David M. Roush, Stephen F. Donovan, Frank J. Zawacki, Walter H. Yeager, John W. Lyga, Daniel H. Cohen
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Patent number: 6872838Abstract: The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.Type: GrantFiled: July 29, 2002Date of Patent: March 29, 2005Assignee: University of KansasInventors: Valentino J. Stella, Jan J. Zygmunt, Ingrid Gunda Georg, Muhammad S. Safadi