Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/427)
  • Patent number: 11149054
    Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: October 19, 2021
    Assignee: SAGE THERAPEUTICS, INC.
    Inventors: Francesco G. Salituro, Albert Jean Robichaud, Gabriel Martinez Botella, Boyd L. Harrison, Andrew Griffin
  • Patent number: 10174254
    Abstract: The present invention relates to a liquid crystal composition, which is a liquid crystal composition containing a compound represented by General Formula (II-1) as an anti-oxidizing agent for a liquid crystal composition containing the compound represented by General Formula (II-1) and also as a first component, and a compound represented by General Formula (K) as a second component. The compound represented by General Formula (II-1) enables obtainment of a working effect of the anti-oxidizing agent, and therefore it allows provision of a liquid crystal composition containing the anti-oxidizing agent which has improved reliability like low temperature stability, while the high dielectric anisotropy is maintained.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 8, 2019
    Assignee: DIC CORPORATION
    Inventors: Go Sudo, Yasuo Umezu
  • Patent number: 9617235
    Abstract: The invention relates to a process for transformation of lignocellulosic biomass or cellulose using in a simultaneous manner an original combination of at least two homogeneous catalysts and one or more heterogeneous catalyst(s). The use of these catalysts makes it possible to obtain mono-oxidized or poly-oxidized upgradable products directly and to limit the formation of non-upgradable products. Non-upgradable products are defined as soluble and non-soluble humins, i.e., products of high molecular weight obtained from undesirable condensation reactions of sugars and their derivatives.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: April 11, 2017
    Assignee: IFP ENERGIES NOUVELLES
    Inventors: Damien Delcroix, Christophe Vallee, Amandine Cabiac, Emmanuelle Guillon
  • Publication number: 20150141667
    Abstract: The present invention provides catalysts, methods, and reactor systems for converting oxygenated hydrocarbons to oxygenated compounds. The invention includes methods for producing cyclic ethers, monooxygenates, dioxygenates, ketones, aldehydes, carboxylic acids, and alcohols from oxygenated hydrocarbons, such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like, using catalysts containing palladium, molybdenum, tin, and tungsten. The oxygenated compounds produced are useful in the production of liquid fuels, chemicals, and other products.
    Type: Application
    Filed: December 30, 2014
    Publication date: May 21, 2015
    Inventors: Brian Blank, Randy Cortright, Taylor Beck, Elizabeth Woods, Mike Jehring
  • Patent number: 9006468
    Abstract: The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the following structure is disclosed.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: April 14, 2015
    Assignee: Dow AgroSciences, LLC.
    Inventors: Gary D. Crouse, Thomas C. Sparks, CaSandra L. McLeod, David A. Demeter, Kristy Bryan, Annette V. Brown, William H. Dent, III, Denise P. Cudworth, Jaime S. Nugent, Ricky Hunter, Jack G. Samaritoni
  • Publication number: 20150087847
    Abstract: There is provided a compound having a good miscibility with another liquid crystal compound and having a combination of a low viscosity (?), high storage stability, and high T?i even after being used to produce a liquid crystal composition. In particular, it is a compound having a 2-fluorophenyloxymethane structure is provided. Since the compound having a 2-fluorophenyloxymethane structure is highly miscible with another liquid crystal compound, using the compound having a 2-fluorophenyloxymethane structure as a component of a liquid crystal composition enables a production of a liquid crystal composition which exhibits a liquid crystal phase at low viscosity and in a wide temperature range and which has a high storage stability and enables production of a liquid crystal display device which responds fast and which has excellent display characteristics.
    Type: Application
    Filed: March 24, 2013
    Publication date: March 26, 2015
    Applicant: DIC CORPORATION
    Inventors: Kenta Tojo, Tetsuo Kusumoto, Masashi Osawa, Masakazu Kaneoya, Kiyofumi Takeuchi
  • Patent number: 8981130
    Abstract: Disclosed are processes for preparing 1,2-cyclohexanediol, and mixtures of 1,2-cyclohexanediol and 1,6-hexanediol, by hydrogenating 1,2,6-hexanetriol.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: March 17, 2015
    Assignee: E I Du Pont de Nemours and Company
    Inventors: Wathudura Indika Namal de Silva, Ekaterini Korovessi, Carl Andrew Menning, Joseph E Murphy, Joachim C Ritter, Sourav Kumar Sengupta
  • Publication number: 20150060732
    Abstract: An object is to provide a liquid crystal compound satisfying at least one of physical properties such as a high stability to heat and light, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant and an excellent compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound, and a liquid crystal display device including the composition. A solution is a compound represented by formula (1). In formula 1, R1 is alkyl having 1 to 10 carbons, for example; ring A1 and ring A2 are independently 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are independently a single bond or —CF2O—; L1 and L2 are halogen; and a is 1 or 2.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 5, 2015
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Yasuyuki GOTOH, Masakazu YANO
  • Publication number: 20150065733
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 5, 2015
    Inventors: Fabio E.S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Teng Ko Ngooi, Jason A. Bexrud, Ricardo Orprecio, Huzaifa Rangwala
  • Publication number: 20150060730
    Abstract: The invention relates to liquid-crystalline compounds of the formula (I) having a —CF20- bridge. The invention also relates to liquid-crystalline media prepared therewith and to liquid-crystal display devices (LC displays) containing these media. This kind of compounds has the excellent characteristics including a large dielectric anisotropy, fast response time and high clearing point, and good miscibility at low temperature in the same time which has important significance in new TFT LC mixture.
    Type: Application
    Filed: August 30, 2013
    Publication date: March 5, 2015
    Applicant: Shijiazhuang Chengzhi Yonghua Display Materials Co., Ltd.
    Inventors: Kai Xu, Jing-yi Feng, Zi-qian Shi, Qing Cui, Xi-zhe Yan, Kui Wang, Jia-lin Chen
  • Publication number: 20150038566
    Abstract: The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.
    Type: Application
    Filed: October 20, 2014
    Publication date: February 5, 2015
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventor: Richard Taylor
  • Publication number: 20150021520
    Abstract: Disclosed is a liquid crystal compound. The compound has a general structural formula as shown by formula I. Such a compound has good thermal and UV stability, large positive dielectric anisotropy ??, and can achieve a low threshold voltage when used in optics, thereby having great significance to the fast response of display devices, and therefore being very suitable for formulating a liquid crystal mixture. A liquid crystal mixture containing such a liquid crystal unit can be applied to various display devices, and is especially suitable for TN-TFT and STN display devices, but can also be used in IPS (in-plane switching) and VA (vertically aligned) display devices.
    Type: Application
    Filed: November 21, 2012
    Publication date: January 22, 2015
    Applicant: Shijiazhuang Chengzhi Yonghua Display Materials Co., Ltd.
    Inventors: Guoliang Yun, Gang Wen, Zhian Liang, Ruimao Hua, Kui Wang, Xing Zhang, Zhiguo Xia, Yaohua Han
  • Publication number: 20140323303
    Abstract: The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is methyl or chlorine; R2 is hydrogen, methyl, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, fluorine, chlorine, bromine, methoxy, ethoxy or fluoromethoxy; and G, R3, R4, R5 and R6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.
    Type: Application
    Filed: November 30, 2012
    Publication date: October 30, 2014
    Applicants: Syngenta Participations AG, Syngenta Limited
    Inventors: Alaric James Avery, Mangala Mahadev Phadte, James Nicholas Scutt, John Benjamin Taylor, Russell Colin Viner, Jeffrey Steven Wailes
  • Publication number: 20140312276
    Abstract: This invention relates to liquid crystal compound of formula I containing a difluoromethyleneoxy linking group that hydrogen substituted by deuterium and therefore being very suitable for formulating a liquid crystal mixture. A liquid crystal mixture containing such type of liquid crystal compounds can be applied in various display devices.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Inventors: Wen Hai LU, Ze Feng HOU, Xing ZHANG, Guo Liang YUN, Rui Mao HUA, Jin WANG, Ya Jie DUAN
  • Patent number: 8846985
    Abstract: Disclosed herein are processes for preparing an ?,?-Cn-diol, wherein n is 5 or greater, from a feedstock comprising a Cn oxygenate. In one embodiment, the process comprises contacting the feedstock with hydrogen gas in the presence of a catalyst comprising a first metal component comprising Ni, Ir, Pt, Rh, Ru, Pd, Fe, Ag, or Au; a heteropoly acid component comprising H3[P(W3O10)4], H4[Si(W3O10)4], H4[P(Mo3O10)4], H4[Si(Mo3O10)4], Cs2.5H0.5[P(W3O10)4]Cs2.5H0.5[Si(W3O10)4], or mixtures thereof; optionally a second metal component comprising Cr, a Cr oxide, Ni, a Ni oxide, Fe, a Fe oxide, Co, a Co oxide, Mn, a Mn oxide, Mo, a Mo oxide, W, a W oxide, Re, a Re oxide, Zn, a Zn oxide, SiO2, or Al2O3; optionally at least one promoter comprising Na, K, Mg, Rb, Cs, Ca, Sr, Ba, Ce, or mixtures thereof; and optionally a support.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: September 30, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Alan Martin Allgeier, Wathudura Indika Namal De Silva, Carl Andrew Menning, Joachim C Ritter, Sourav Kumar Sengupta
  • Patent number: 8846984
    Abstract: Disclosed herein are processes for preparing an ?,?-Cn-diol, wherein n is 5 or greater, from a feedstock comprising a Cn oxygenate. In one embodiment, the process comprises contacting the feedstock with hydrogen gas in the presence of a catalyst comprising Cu, a Cu oxide, or mixtures thereof; a heteropoly acid component comprising H3[P(W3O10)4], H4[Si(W3O10)4], H4[P(Mo3O10)4], H4[Si(Mo3O10)4], Cs2.5H0.5[P(W3O10)4], Cs2.5H0.5[Si(W3O10)4], or mixtures thereof; optionally a second metal component comprising Cr, a Cr oxide, Ni, a Ni oxide, Mn, a Mn oxide, Fe, an Fe oxide, Co, a Co oxide, Mo, a Mo oxide, W, a W oxide, Re, a Re oxide, Zn, or a Zn oxide, Ag, a Ag oxide, SiO2, or Al2O3; optionally at least one promoter comprising Na, K, Mg, Rb, Cs, Ca, Sr, Ba, Ce, or mixtures thereof; and optionally a support.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: September 30, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Alan Martin Allgeier, Wathudura Indika Namal De Silva, Carl Menning, Joseph E Murphy, Joachim C Ritter, Sourav Kumar Sengupta
  • Publication number: 20140275577
    Abstract: The present invention relates to a compound having a 2-fluorophenyloxymethane structure and useful for organic electronic materials and medical and agricultural chemicals, particularly materials for liquid crystal display elements. A problem to be solved by the invention is to provide a compound having relatively large ??, relatively high T?i, low viscosity (?), and high miscibility with other liquid crystal compounds, and also provide a liquid crystal composition containing the compound as a constituent component. The present invention provides a compound having a 2-fluorophenyloxymethane structure and also provides a liquid crystal composition containing the compound and a liquid crystal display device using the liquid crystal composition.
    Type: Application
    Filed: May 22, 2012
    Publication date: September 18, 2014
    Applicant: DIC CORPORATION
    Inventors: Kenta Tojo, Kiyofumi Takeuchi, Masashi Osawa, Masakazu Kaneoya, Tetsuo Kusumoto
  • Publication number: 20140221330
    Abstract: An objective of the present invention is to provide a novel NDM (New Delhi metallo-?-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of ?-lactam antibiotics that have been inactivated as a result of decomposition by NDM.
    Type: Application
    Filed: July 26, 2012
    Publication date: August 7, 2014
    Inventors: Akihiro Morinaka, Kazunori Maebashi, Takashi Ida, Muneo Hikida, Mototsugu Yamada, Takao Abe
  • Publication number: 20140145113
    Abstract: A liquid crystal compound having high stability to heat, light and so forth, a high clearing point, a low minimum temperature of a liquid crystal phase, small viscosity, suitable optical anisotropy, large dielectric anisotropy, a suitable elastic constant and excellent compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound, and a liquid crystal display device including the composition. The compound is represented by formula (1-1): wherein, for example, R1 is hydrogen, halogen or alkyl having 1 to 20 carbons; ring A1, ring A2, ring A3, ring A4 and ring A5 are independently 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2, Z3 and Z4 are independently a single bond, —(CH2)2—, —CH?CH— or —CF?CF—: and a, b, c and d are independently 0 or 1, and a sum of a, b, c and d is one or more.
    Type: Application
    Filed: November 26, 2013
    Publication date: May 29, 2014
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Tomohiro YANO, Junichi YAMASHITA
  • Patent number: 8735322
    Abstract: Cyclohexanedione compounds, which are suitable for use as herbicides.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: May 27, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, John Martin Clough, Kevin Beautement, Melloney Tyte, Louisa Robinson, Stephane AndréMarie Jeanmart
  • Publication number: 20140097383
    Abstract: A liquid crystal composition and an AM liquid crystal display device are described. The liquid crystal composition contains a specific compound having a small viscosity as a first component, may further contain a specific compound having a large negative dielectric anisotropy as a second component and a specific compound having a small viscosity as a third component, and has a negative dielectric anisotropy and a ratio of rotational viscosity to an elastic constant in the range of 4.2 GPa·s/N or lower. The liquid crystal display device includes the composition.
    Type: Application
    Filed: February 8, 2013
    Publication date: April 10, 2014
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Yoshimasa Furusato, Masayuki Saito
  • Patent number: 8680339
    Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: March 25, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20140051872
    Abstract: The present invention provides catalysts, methods, and reactor systems for converting oxygenated hydrocarbons to oxygenated compounds. The invention includes methods for producing cyclic ethers, monooxygenates, dioxygenates, ketones, aldehydes, carboxylic acids, and alcohols from oxygenated hydrocarbons, such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like, using catalysts containing palladium, molybdenum, tin, and tungsten. The oxygenated compounds produced are useful in the production of liquid fuels, chemicals, and other products.
    Type: Application
    Filed: August 15, 2012
    Publication date: February 20, 2014
    Applicant: Virent, Inc.
    Inventors: Brian Blank, Randy Cortright, Taylor Beck, Elizabeth Woods, Mike Jehring
  • Publication number: 20140028964
    Abstract: The invention relates to a liquid-crystalline medium which comprises at least one compound of the formula I, in which R1, R1*, rings A and B, Z1, L1, L2, a and b have the meanings indicated in Claim 1, and to the use thereof for an active-matrix display, in particular based on the VA, PSA, PS-VA, PALC, FFS, PS-FFS, IPS or PS-IPS effect.
    Type: Application
    Filed: March 8, 2012
    Publication date: January 30, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Melanie Klasen-Memmer, Achim Goetz, Georg Bernatz
  • Publication number: 20140027671
    Abstract: To provide a liquid crystal composition satisfying at least one characteristic such as high maximum temperature of nematic phase, low minimum temperature thereof, small viscosity, suitable optical anisotropy, large negative dielectric anisotropy and specific resistance, high stability to ultraviolet light and heat; a liquid crystal composition having a suitable balance regarding at least two thereof; and an AM device including the composition.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 30, 2014
    Inventors: YASUYUKI GOTOH, TEIZI SATOU, MAIKO MATSUKUMA, CHIKAHIDE KANADANI, YOSHIMASA FURUSATO
  • Publication number: 20140021406
    Abstract: A liquid crystal compound having a high stability to heat, light and so forth, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant and an excellent solubility in other liquid crystal compounds, a liquid crystal composition containing the compound, and a liquid crystal display device including the composition. The compound is represented by formula (1): wherein, for example, R1 is fluorine or alkyl having 1 to 10 carbons; ring A1 and ring A2 are 1,4-phenylene, or 1,4-phenylene in which at least one of hydrogen is replaced by fluorine; Z1, Z2 and Z3 are a single bond; L1 and L2 are hydrogen or fluorine; X1 is fluorine or —CF3; and m is 1, and n is 0.
    Type: Application
    Filed: July 10, 2013
    Publication date: January 23, 2014
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Yasuyuki GOTOH, Keiji KIMURA
  • Patent number: 8633182
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: January 21, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Dieter Hamprecht, Sara Frattini, Iain Lingard, Stefan Peters
  • Publication number: 20130306908
    Abstract: The present invention relates to liquid-crystalline compounds containing an O-heterocyclic ring, three partially fluorinated benzene rings and a —CF2O— bridge between the rings. In addition, the invention relates to liquid-crystalline media prepared therewith and to liquid-crystal display devices (LC displays) containing these media.
    Type: Application
    Filed: December 30, 2011
    Publication date: November 21, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Axel Jansen, Matthias Bremer, Michael Wittek, Helmut Haensel, Malgorzata Rillich, Julia Sprang
  • Patent number: 8585922
    Abstract: The invention relates to a liquid-crystalline medium comprising one or more compounds of the formula I in which R0, ring A and L1-4 have the meanings indicated in Claim 1, and to the use thereof in electro-optical liquid-crystal displays.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: November 19, 2013
    Assignee: MERCK PATENT GmbH
    Inventors: Michael Wittek, Brigitte Schuler, Harald Hirschmann, Volker Reiffenrath, Markus Czanta, Christian Schoenefeld
  • Patent number: 8580142
    Abstract: The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, a suitable elastic constant K33, a suitable and negative dielectric anisotropy, and an excellent compatibility with other liquid crystal compounds. The invention provides a liquid crystal composition containing the compound described above and having stability to heat, light and so forth, a small viscosity, a suitable optical anisotropy, a suitable and negative dielectric anisotropy, a suitable elastic constant K33, a low threshold voltage, a high maximum temperature of a nematic phase, and a low minimum temperature of the nematic phase. The invention also provides a liquid crystal display device having a short response time, a small power consumption, a low driving voltage, and a large contrast, and containing the composition described above which can be used in a large temperature range.
    Type: Grant
    Filed: September 1, 2008
    Date of Patent: November 12, 2013
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventors: Teru Shimada, Masahide Kobayashi
  • Publication number: 20130281580
    Abstract: The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g.
    Type: Application
    Filed: October 19, 2011
    Publication date: October 24, 2013
    Applicant: BIOFORMIX INC.
    Inventors: Bernard M. Malofsky, Adam G. Malofsky, Tanmoy Dey, Jeffrey M. Sullivan, Yangbin Chen, Stanley C. Wojciak, Michael C. Cockrem
  • Publication number: 20130277610
    Abstract: To provide a liquid crystal compound having a large negative value of dielectric anisotropy (As). A compound is represented by formula (1): wherein, in formula (1), one of Y1 and Y2 is fluorine, and the other is CF2H or CF3; G is a ring represented by formula (pr-1) or formula (pr-2): wherein A1 to A3 are independently 1,4-cyclohexylene or 1,4-phenylene; Ra and Rb are independently hydrogen, alkyl having 1 to 20 carbons, or the like; Z0, and Z1 to Z3 are independently a single bond, —(CH2)2—, —CH?CH—, —CF2O—, —OCF2—, —CH2O—, —OCH2—, —COO— or —OCO—; j, m and n are an integer from 0 to 2, and a sum of j, m and n is 0, 1 or 2, however, when m is 0, Y1 is CF2H or CF3, Y2 is fluorine, and Z0 is a single bond, G is a ring represented by formula (pr-1).
    Type: Application
    Filed: April 18, 2013
    Publication date: October 24, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Mayumi GOTO, Sayaka FUJIMORI
  • Publication number: 20130240784
    Abstract: To provide a liquid crystal compound having a large negative dielectric anisotropy (??), and having at least one of characteristics such as a high stability to heat, light and so forth, a high clearing point, a suitable refractive index anisotropy (?n) and an excellent compatibility with other liquid crystal compounds, and an intermediate thereof. A solution is a compound represented by formula (1): wherein, for example, R1 and R2 are alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; ring A1, ring A2 and ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or —(CH2)2—; X is —CF2— or —CHF—; and l, m and n are 0 or 1.
    Type: Application
    Filed: December 9, 2011
    Publication date: September 19, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Kenji Hirata, Hiroki Ookawa
  • Patent number: 8513162
    Abstract: There is provided a halogen-containing organosulfur compound having a controlling effect on arthropod pests represented by the formula (I): wherein m represents 0, 1 or 2; n represents 0, 1 or 2; A represents an optionally substituted 3- to 8-membered saturated heterocyclic group; Q represents a fluorine atom or a C1-C5 haloalkyl group having at least one fluorine atom; R1, R1a and R3 independently represent an optionally halogenated C1-C4 chain hydrocarbon group, etc.; R2, R2a and R4 independently represent an optionally halogenated C1-C4 chain hydrocarbon group, etc.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: August 20, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiromasa Mitsudera
  • Publication number: 20130197229
    Abstract: Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substituted compounds.
    Type: Application
    Filed: October 13, 2011
    Publication date: August 1, 2013
    Inventors: Christopher Matthews, Colin O'Bryan, David Paul Provencal
  • Publication number: 20130172580
    Abstract: Disclosed are processes comprising contacting an aqueous reaction mixture having an initial pH between about 3 and about 6 and comprising levoglucosenone with a catalyst, and heating the reaction mixture to form a product mixture comprising 5-hydroxymethyl-2-furfural. The processes may further comprise heating the product mixture comprising 5-hydroxymethyl-2-furfural in the presence of hydrogen and a hydrogenation catalyst to form a second product mixture comprising one or more of 2,5-furandimethanol, tetrahydrofuran 2,5-dimethanol, 1,2,6-hexanetriol, 2-hydroxymethyltetrahydropyran, and 1,6-hexanediol.
    Type: Application
    Filed: December 28, 2012
    Publication date: July 4, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: E I DU PONT DE NEMOURS AND COMPANY
  • Publication number: 20130172579
    Abstract: Disclosed are processes for preparing 1,2-cyclohexanediol, and mixtures of 1,2-cyclohexanediol and 1,6-hexanediol, by hydrogenating 1,2,6-hexanetriol.
    Type: Application
    Filed: December 28, 2012
    Publication date: July 4, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: E I DU PONT DE NEMOURS AND COMPANY
  • Patent number: 8389073
    Abstract: The invention provides a liquid crystal compound that has a large negative dielectric anisotropy (??) and also has at least one of characteristics such as the stability to heat, light or the like, a high clearing point, a suitable refractive index anisotropy (?n), a large negative dielectric anisotropy (??) and an excellent compatibility with other liquid crystal compounds. An excellent effect in which especially the value of the dielectric anisotropy (??) is increased negatively is achieved by use of the compound having two moieties of 1) a tetrahydropyran ring and and thus the effect is utilized.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: March 5, 2013
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventors: Kenji Hirata, Tokifumi Masukawa, Junichi Yamashita, Maiko Ito
  • Publication number: 20130053385
    Abstract: The use of a compound of formula I wherein the substituents are as defined in claim 1, or compositions containing them in controlling insects, acarines, nematodes or molluscs.
    Type: Application
    Filed: December 7, 2010
    Publication date: February 28, 2013
    Applicants: SYNGENTA LIMITED, SYNGENTA CROP PROTECTION LLC
    Inventors: Stephane Andre Marie Jeanmart, Russell Viner, John Benjamin Taylor, William Guy Whittingham, Jeffrey Steven Wailes, Sarah Margaret Targett, Christopher John Mathews, Michel Muehlebach
  • Patent number: 8372879
    Abstract: 4-(heterocycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below: Also described, are compositions including the same, processes for preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: February 12, 2013
    Assignee: Galderma Research & Development
    Inventors: Jean-Guy Boiteau, Jean-Claude Pascal
  • Patent number: 8372306
    Abstract: A liquid crystal compound is provided that has excellent characteristics, such as a negatively large dielectric anisotropy. A liquid crystal composition containing the compound, and a liquid crystal display device containing the composition are also provided. A compound having the three factors, i.e., (1) a tetrahydropyran ring, (2) terminal alkenyl chain and (3) exhibits excellent characteristics including a negatively large dielectric anisotropy (??). The use of the compound having the characteristics provides an excellent liquid crystal composition and an excellent liquid crystal display device.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: February 12, 2013
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventor: Tokifumi Masukawa
  • Patent number: 8372975
    Abstract: The invention provides a liquid crystal compound having general physical properties necessary for the compound, namely stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large optical anisotropy and a large dielectric anisotropy; a compound represented by formula (1): wherein, for example, R1 is alkyl having 1 to 20 carbons; ring A1 and ring A4 each are 1,4-cyclohexylene, 1,4-phenylene, or 1,4-phenylene in which arbitrary hydrogen is replaced by halogen; Z1 and Z4 each are a single bond; L1, L2, L3 and L4 each are hydrogen or fluorine; and X1 is fluorine, chlorine, —CF3 or —OCF3.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: February 12, 2013
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventor: Hiroyuki Tanaka
  • Publication number: 20120145958
    Abstract: A compound represented by formula (1-1) or (1-2) is provided. For example, R1 and R2 are independently hydrogen, alkyl having 1 to 10 carbons or alkoxy having 1 to 9 carbons; the ring A1, the ring A2, the ring A3, the ring A4, the ring A5 and the ring A6 are independently 1,4-cyclohexylene or 1,4-phenylene; a, b, c, d, e and f are independently 0 or 1, and the sum of a, b, c, d, e and f is 2; and g, h, i, j, k and l are independently 0 or 1, and the sum of g, h, i, j, k and l is 2.
    Type: Application
    Filed: August 10, 2010
    Publication date: June 14, 2012
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Tokifumi Masukawa, Kenji Hirata, Junichi Yamashita
  • Patent number: 8187494
    Abstract: The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, and a suitable elastic constant K33, and further having a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds, and a liquid crystal composition having stability to heat, light and so forth, a low viscosity, a large optical anisotropy, a suitable and negative dielectric anisotropy, and a suitable elastic constant K33, a low threshold voltage, a high maximum temperature (phase-transition temperature on a nematic phase-isotropic phase) of a nematic phase, and a low minimum temperature of the nematic phase. The liquid crystal compound which has a specific structure having fluorine at a lateral position and also having phenylene in which hydrogen on the benzene ring is replaced by fluorine, and a liquid crystal composition containing the compound are prepared.
    Type: Grant
    Filed: August 26, 2008
    Date of Patent: May 29, 2012
    Assignees: JNC Corporation, Chisso Petrochemical Corporation
    Inventors: Masahide Kobayashi, Teru Shimada
  • Publication number: 20120129894
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: May 19, 2011
    Publication date: May 24, 2012
    Applicant: Acucela Inc.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas Little, Anna Gall, Feng Hong
  • Publication number: 20120071457
    Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.
    Type: Application
    Filed: November 29, 2011
    Publication date: March 22, 2012
    Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
  • Publication number: 20120041213
    Abstract: 4-(heterocycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below: Also described, are compositions including the same, processes for preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders.
    Type: Application
    Filed: December 2, 2009
    Publication date: February 16, 2012
    Applicant: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Jean-Guy Boiteau, Jean-Claude Pascal
  • Patent number: 8115019
    Abstract: Disclosed are cis-2,6-disubstituted tetrahydropyran derivatives represented by Chemical Formula 1 and a preparation method thereof. The tetrahydropyran derivatives can be prepared by Prins-reacting tetrahydropyran derivatives with homopargylicalcohol derivatives in the presence of trimethylsilyltriflate. The tetrahydropyran derivatives with cis-substituents at both C2 and C6 positions of the tetrahydropyran ring are useful as intermediates for use in the synthesis and development of therapeutically effective, naturally occurring compounds. (wherein, R1, R2 and R3 are as defined in the specification.).
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: February 14, 2012
    Assignee: Korea Institute of Science and Technology
    Inventors: Yong Seo Cho, You Seung Kim, Jae Kyun Lee, Hyunah Choo, Ae Nim Pae
  • Publication number: 20120035053
    Abstract: Cyclohexanedione compounds, which are suitable for use as herbicides.
    Type: Application
    Filed: September 23, 2009
    Publication date: February 9, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, John Martin Clough, Kevin Beautement, Melloney Tyte, Louisa Robinson, Stephane André Marie Jeanmart
  • Publication number: 20120028800
    Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: January 25, 2010
    Publication date: February 2, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney