Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/427)
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Publication number: 20120035053Abstract: Cyclohexanedione compounds, which are suitable for use as herbicides.Type: ApplicationFiled: September 23, 2009Publication date: February 9, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Christopher John Mathews, John Martin Clough, Kevin Beautement, Melloney Tyte, Louisa Robinson, Stephane André Marie Jeanmart
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Publication number: 20120029194Abstract: The invention provides a liquid crystal compound having general physical properties necessary for the compound, namely stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large optical anisotropy and a large dielectric anisotropy; a compound represented by formula (1): wherein, for example, R1 is alkyl having 1 to 20 carbons; ring A1 and ring A4 each are 1,4-cyclohexylene, 1,4-phenylene, or 1,4-phenylene in which arbitrary hydrogen is replaced by halogen; Z1 and Z4 each are a single bond; L1, L2, L3 and L4 each are hydrogen or fluorine; and X1 is fluorine, chlorine, —CF3 or —OCF3.Type: ApplicationFiled: March 15, 2010Publication date: February 2, 2012Applicants: CHISSO PETROCHEMICAL CORPORATION, JNC CORPORATIONInventor: Hiroyuki Tanaka
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Publication number: 20120028800Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: January 25, 2010Publication date: February 2, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
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Publication number: 20120018672Abstract: The invention provides a liquid crystal compound having a high stability to heat, light or the like, a wide temperature range of a nematic phase, a small viscosity, a large optical anisotropy and a suitable elastic constant K33, and further having a suitable negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds. The invention also provides a liquid crystal composition including this liquid crystal compound and a liquid crystal display device containing this liquid crystal composition. A liquid crystal compound represented by formula (a): For example, Ra and Rb are alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkoxy having 1 to 9 carbons; the ring A1 and the ring A2 are 1,4-phenylene or trans-1,4-cyclohexylene; L1, L2, L3 and L4 are hydrogen or fluorine, and at least three of them are fluorine; and Z1 and Z2 are a single bond, —(CH2)2—, —CH?CH—, —CH2O— or —OCH2—.Type: ApplicationFiled: January 12, 2010Publication date: January 26, 2012Applicants: CHISSO PETROCHEMICAL CORPORATION, JNC CORPORATIONInventor: Masahide Kobayashi
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Publication number: 20110297881Abstract: The invention provides a liquid crystal compound that has a large negative dielectric anisotropy (??) and also has at least one of characteristics such as the stability to heat, light or the like, a high clearing point, a suitable refractive index anisotropy (?n), a large negative dielectric anisotropy (??) and an excellent compatibility with other liquid crystal compounds. An excellent effect in which especially the value of the dielectric anisotropy (??) is increased negatively is achieved by use of the compound having two moieties of 1) a tetrahydropyran ring and and thus the effect is utilized.Type: ApplicationFiled: February 1, 2010Publication date: December 8, 2011Applicants: CHISSO PETROCHEMICAL CORPORATION, JNC CORPORATIONInventors: Kenji Hirata, Tokifumi Masukawa, Junichi Yamashita, Maiko Ito
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Publication number: 20110291047Abstract: A liquid crystal compound having general physical properties necessary for a liquid crystal compound, a high stability to heat, light or the like, a small viscosity, a suitable refractive index anisotropy, a suitable dielectric anisotropy and steep electro-optic characteristics, a wide temperature range of a nematic phase and an excellent compatibility with other liquid crystal compounds, and a liquid crystal compound especially having a wide temperature range of a nematic phase. A compound represented by formula (1). with, for example, R1 and R2 are alkyl having 1 to 10 carbons; A1 is 1,4-cyclohexylene; A2 is 2,3-difluoro-1,4-phenylene; X is fluorine or chlorine; Z1 and Z2 are a single bond; and p and q is 0 or 1.Type: ApplicationFiled: May 24, 2011Publication date: December 1, 2011Applicants: CHISSO PETROCHEMICAL CORPORATION, JNC CORPORATIONInventor: Tomohiro YANO
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Publication number: 20110275515Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: January 18, 2010Publication date: November 10, 2011Applicant: SYNGENTA CROP PROTECTION, LLCInventors: William Guy Whittingham, Christopher John Mathews, Jeffrey Steven Wailes, Stephane André Marie Jeansmart, Louisa Robinson
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Publication number: 20110269713Abstract: Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.Type: ApplicationFiled: October 14, 2010Publication date: November 3, 2011Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Gary E. Keck, Matthew B. Kraft, Anh P. Truong, Carina C. Sanchez, Wei Li, Jonathan A. Covel, Dennie Welch, Yam Poudel
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Publication number: 20110263428Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: July 1, 2009Publication date: October 27, 2011Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Stephane Andre Marie Jeanmart, Russell Colin Viner, John Benjamin Taylor, William Guy Whittingham, Jeffrey Steven Wailes, Sarah Margaret Targett, Christopher John Mathews, Mangala Govenkar, Matthew Robert Cordingley, Claire Janet Russell, Melloney Tyte
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Publication number: 20110253934Abstract: The invention relates to mesogenic tetrahydropyran compounds having at least four rings, of the formula I in which R1, A1, A2, X1, L1, L2, m and n have the meanings indicated in Claim 1, and to a process for the preparation thereof, to the use thereof in liquid-crystalline media, to liquid-crystalline media comprising at least one compound of the formula I, and to electro-optical displays containing a liquid-crystalline medium of this type.Type: ApplicationFiled: July 17, 2007Publication date: October 20, 2011Inventors: Lars Lietzau, Markus Czanta, Atsutaka Manabe
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Publication number: 20110233466Abstract: The present invention relates to liquid-crystalline compounds having at least three fluorine-substituted benzene rings, a terminal trifluoromethyl group and at least one —CF2O— bridge. The invention also relates to liquid-crystalline media prepared therewith and to liquid-crystal display devices (LC displays) containing these media.Type: ApplicationFiled: March 22, 2011Publication date: September 29, 2011Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Axel JANSEN, Helmut Haensel, Philipp Krattiger, Andreas Taugerbeck, Malgorzata Rillich
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Patent number: 7977344Abstract: The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.Type: GrantFiled: February 15, 2008Date of Patent: July 12, 2011Assignee: GlaxoSmithKline LLCInventors: Linos Lazarides, Stephen Allan Smith, Richard Stocker, Colin Jack Theobald
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Patent number: 7968003Abstract: The present invention relates to a pyran derivative which manifests appropriate refractive anisotropy (optical anisotropy) and liquid crystal transition temperature and excellent dielectric anisotropy, and has excellent compatibility with various liquid crystal compounds, and thus, can be preferably used for the formation of a liquid crystal layer of a liquid crystal display device, its preparation method, a liquid crystal composition and liquid crystal display device comprising the same.Type: GrantFiled: September 9, 2009Date of Patent: June 28, 2011Assignee: LG Chem, Ltd.Inventors: Bum-Gyu Choi, Min-Jin Ko, Myung-Sun Moon, Jae-Ho Cheong, Dae-Ho Kang, Ki-Youl Lee, Yun-Bong Kim
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Patent number: 7914862Abstract: A liquid crystal compound is provided that has excellent characteristics, such as a negatively large dielectric anisotropy. A liquid crystal composition containing the compound, and a liquid crystal display device containing the composition are also provided. A compound having the three factors, i.e., (1) a tetrahydropyran ring, (2) —CH2O— or —OCH2— and (3) exhibits excellent characteristics including a negatively large dielectric anisotropy. The use of the compound having the characteristics provides an excellent liquid crystal composition and an excellent liquid crystal display device.Type: GrantFiled: May 4, 2009Date of Patent: March 29, 2011Assignees: Chisso Corporation, Chisso Petrochemical CorporationInventor: Tokifumi Masukawa
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Publication number: 20110037024Abstract: The invention provides a liquid crystal compound represented by the following formula having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a large optical anisotropy and a suitable elastic constant K33 (K33: bend elastic constant), and further having a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds, and provides a liquid crystal composition including the compound, wherein R1 and R2 are hydrogen, alkyl or the like, ring A1 is trans-1,4-cyclohexylene, 1,4-phenylene or the like, L1 to L4 are hydrogen or fluorine, and at least three of them are fluorine; when the ring A1 is trans-1,4-cyclohexylene or the like, Z1 is a single bond, —(CH2)2— or the like, when ring A1 is 1,4-phenylene, Z1 is —(CH2)2— or the like.Type: ApplicationFiled: March 25, 2009Publication date: February 17, 2011Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATIONInventor: Masahide Kobayashi
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Patent number: 7888519Abstract: The invention relates to pyran derivatives of the formula I and to a process and intermediates for their preparation and derivatisation, and to the use thereof in liquid-crystalline media.Type: GrantFiled: May 27, 2004Date of Patent: February 15, 2011Assignee: Merck Patent GesellschaftInventors: Eike Poetsch, Werner Binder, Volker Meyer, Michael Heckmeier, Georg Luessem
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Publication number: 20110021794Abstract: Disclosed is a process for the manufacture of a compound of formula (I) wherein Hal represents fluoro or chloro, and R1 and R2 represent, independently from one another, hydrogen or Hal; in which process a compound of formula (II) is converted to a corresponding alkyl, fluoroalkyl or aryl sulfonic acid ester, which is then reacted with an alkali metal nitrite in the presence of a suitable crown ether in a polar non-nucleophilic solvent at a temperature of ?10 to 50° C. to give the compound of formula (I).Type: ApplicationFiled: August 31, 2010Publication date: January 27, 2011Inventors: Marc Muller, Lin Xu
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Publication number: 20110001090Abstract: The invention relates to a liquid-crystalline medium comprising one or more compounds of the formula I in which R0, ring A and L1-4 have the meanings indicated in claim 1, and to the use thereof in electro-optical liquid-crystal displays.Type: ApplicationFiled: February 19, 2009Publication date: January 6, 2011Inventors: Michael Wittek, Brigitte Schuler, Harald Hirschmann, Volker Reiffenrath, Markus Czanta, Christian Schoenefeld
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Publication number: 20100328600Abstract: The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, a suitable elastic constant K33, a suitable and negative dielectric anisotropy, and an excellent compatibility with other liquid crystal compounds. The invention provides a liquid crystal composition containing the compound described above and having stability to heat, light and so forth, a small viscosity, a suitable optical anisotropy, a suitable and negative dielectric anisotropy, a suitable elastic constant K33, a low threshold voltage, a high maximum temperature of a nematic phase, and a low minimum temperature of the nematic phase. The invention also provides a liquid crystal display device having a short response time, a small power consumption, a low driving voltage, and a large contrast, and containing the composition described above which can be used in a large temperature range.Type: ApplicationFiled: September 1, 2008Publication date: December 30, 2010Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATIONInventors: Teru Shimada, Masahide Kobayashi
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Publication number: 20100314582Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising one or more compounds of the formula I in which the parameters have the meaning indicated in the specification, and optionally one or more compounds selected from the group of the compounds of the formulae II and III in which the parameters have the meaning indicated in the specification, and optionally one or more compounds of the formula IV in which the parameters have the meaning indicated in the specification, and to liquid-crystal displays containing these media, especially to active-matrix displays and in particular to TN, IPS and FFS displays.Type: ApplicationFiled: January 23, 2009Publication date: December 16, 2010Inventors: Michael Wittek, Markus Czanta, Atsutaka Manabe, Lars Lietzau, Marcus Reuter, Brigitte Schuler, Elisabeth Meyer
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Publication number: 20100309402Abstract: The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, and a suitable elastic constant K33, and further having a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds, and a liquid crystal composition having stability to heat, light and so forth, a low viscosity, a large optical anisotropy, a suitable and negative dielectric anisotropy, and a suitable elastic constant K33, a low threshold voltage, a high maximum temperature (phase-transition temperature on a nematic phase-isotropic phase) of a nematic phase, and a low minimum temperature of the nematic phase. The liquid crystal compound which has a specific structure having fluorine at a lateral position and also having phenylene in which hydrogen on the benzene ring is replaced by fluorine, and a liquid crystal composition containing the compound are prepared.Type: ApplicationFiled: August 26, 2008Publication date: December 9, 2010Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATIONInventors: Masahide Kobayashi, Teru Shimada
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Patent number: 7842357Abstract: A compound represented by the following formula (1): wherein R1 and R2 are, for example alkyl; T1, T2 and T3 are independently tetrahydropyran-2,5-diyl or tetrahydropyran-3,6-diyl; A1 and A2 are, for example 1,4-cyclohexylene; Z1, Z2, Z3 and Z4 are, for example, a single bond; i, j, k, m and n are, for example 0 or 1; and i+j+k+m+n is, for example 2 or 3.Type: GrantFiled: October 4, 2005Date of Patent: November 30, 2010Assignees: Chisso Corporation, Chisso Petrochemical CorporationInventors: Tokifumi Masukawa, Atsuko Fujita
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Publication number: 20100261772Abstract: The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation.Type: ApplicationFiled: May 24, 2010Publication date: October 14, 2010Inventors: Jing Fang, Dennis Heyer, Subba Reddy Katamreddy, Kenneth William Batchelor, Richard Dana Caldwell
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Publication number: 20100237285Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, V, a, b and c have the meanings indicated in Claim 1, and to liquid-crystalline media comprising at least one compound of the formula I, and to electro-optical displays containing a liquid-crystalline medium of this type.Type: ApplicationFiled: July 18, 2007Publication date: September 23, 2010Inventors: Lars Lietzau, Markus Czanta, Atsutaka Manabe, Kai Jaehrling
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Publication number: 20100228015Abstract: This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and Rb is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.Type: ApplicationFiled: April 23, 2010Publication date: September 9, 2010Inventors: Mitchell A. deLong, Jill M. McFadden, Susan M. Royalty, Eric J. Toone, Jeffrey D. Yingling
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Patent number: 7767277Abstract: Disclosed are compounds of formula I processes for the preparation thereof, and liquid-crystalline media and electro-optical displays containing said compounds.Type: GrantFiled: September 12, 2007Date of Patent: August 3, 2010Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Lars Lietzau, Markus Czanta, Harald Hirschmann, Michael Wittek
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Publication number: 20100127211Abstract: The invention provides a five-ring liquid crystal compound having a CF2O bonding group as a new compound having a general physical properties necessary for compounds, stability to heat, light and so forth, a wide temperature range of liquid crystal phases, a high clearing point, a good compatibility with other compounds, a large dielectric anisotropy and refractive index anisotropy, and an especially high clearing point and an especially large refractive index anisotropy, and provides a liquid crystal composition and a liquid crystal display device.Type: ApplicationFiled: February 20, 2008Publication date: May 27, 2010Applicants: Chisso Corporation, Chisso Petrochemical CorporationInventor: Hiroyuki Tanaka
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Publication number: 20100113763Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having <Chemistry Formula 11> and <Chemistry Formula 12>, respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.Type: ApplicationFiled: October 26, 2009Publication date: May 6, 2010Applicants: FUTURECHEM CO., LTD., THE ASAN FOUNDATIONInventors: Dae Hyuk MOON, Dae Yoon CHI, Dong Wook KIM, Seung Jun OH, Jin-sook RYU
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Patent number: 7651742Abstract: The present invention relates to a liquid-crystalline medium comprising 1,2-difluoroethene compounds of the general formula I, in which R1, ring A, Z1, Z2, m, X and L1-6 are as defined in claim 1. The invention also relates to the use of the medium for electro-optical purposes and to displays containing this medium. Novel 1,2-difluoroethene compounds having 3 or more rings are disclosed.Type: GrantFiled: May 18, 2006Date of Patent: January 26, 2010Assignee: Merck Patent GmbHInventors: Michael Wittek, Markus Czanta, Harald Hirschmann, Volker Reiffenrath
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Patent number: 7638641Abstract: The invention relates to tetrahydropyran derivatives of the general formula I and to processes for the preparation thereof.Type: GrantFiled: November 17, 2003Date of Patent: December 29, 2009Assignee: Merck Patent GmbHInventors: Peer Kirsch, Alexander Hahn, Eike Poetsch, Werner Binder, Volker Meyer
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Patent number: 7638256Abstract: Silicon compounds having fluorinated hemiacetal structure are provided. Silicone resins having the same structure have an appropriate acidity to enable formation of a finer pattern by minimizing the pattern collapse by swelling, exhibit improved resistance to the etching used in the pattern transfer to an organic film, and are thus suited for use in resist compositions for the bilayer process.Type: GrantFiled: July 6, 2006Date of Patent: December 29, 2009Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeshi Kinsho, Takeru Watanabe, Mutsuo Nakashima, Yoshitaka Hamada
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Publication number: 20090278088Abstract: A liquid crystal compound is provided that has excellent characteristics, such as a negatively large dielectric anisotropy. A liquid crystal composition containing the compound, and a liquid crystal display device containing the composition are also provided. A compound having the three factors, i.e., (1) a tetrahydropyran ring, (2) —CH2O— or —OCH2— and (3) exhibits excellent characteristics including a negatively large dielectric anisotropy. The use of the compound having the characteristics provides an excellent liquid crystal composition and an excellent liquid crystal display device.Type: ApplicationFiled: May 4, 2009Publication date: November 12, 2009Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATIONInventor: TOKIFUMI MASUKAWA
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Publication number: 20090270494Abstract: A compound of general formula (I): wherein Xi is H or COR1 and X2 is H or COR2 but X1 and X2 are not both H; R1 and R2 are the same or different and are each C1-4 alkyl substituted with R3, or a four to seven-membered ring which can be optionally substituted with R8 and can contain one or more additional heteroatoms selected from O, S(O)n and NR9; R3 is F, CF3, OR4, NR5R6 or S(O)nR7; R4, R5 and R6 are the same or different and are each H or C1-4 alkyl optionally substituted with R3, or NR5R6 is a C4-6 heterocycloalkyl ring containing one or more heteroatoms selected from O, NR8 and S(O)n; each n is 0-2; R7 is C1-4 alkyl; R8 is as defined for R3 or C1-4 alkyl optionally substituted with R3 or halogen; R9 is H or C1-4 alkyl; Y is NR9R10R11; and R10 and R11, are the same or different and are each H or C1-6 alkyl optionally substituted with R3 or halogen, or NR10R11, is a four to seven membered ring which can be optionally substituted with R8 or COR1, and can contain one or more additional heteroatoms selected frType: ApplicationFiled: November 9, 2007Publication date: October 29, 2009Inventor: Andrea Walmsley
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Publication number: 20090221824Abstract: A process for the production of compounds comprising the enantioselective hydrogenation of 2-substituted acrylic acid derivatives.Type: ApplicationFiled: August 12, 2005Publication date: September 3, 2009Inventors: Paul Howard Briner, Matthew Colin Thor Fyfe, John Paul Madeley, Peter John Murray, Martin James Procter, Felix Spindler
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Publication number: 20090209770Abstract: Disclosed are cis-2,6-disubstituted tetrahydropyran derivatives represented by Chemical Formula 1 and a preparation method thereof. The tetrahydropyran derivatives can be prepared by Prins-reacting tetrahydropyran derivatives with homopargylicalcohol derivatives in the presence of trimethylsilyltriflate. The tetrahydropyran derivatives with cis-substituents at both C2 and C6 positions of the tetrahydropyran ring are useful as intermediates for use in the synthesis and development of therapeutically effective, naturally occurring compounds. (wherein, R1, R2 and R3 are as defined in the specification.Type: ApplicationFiled: October 1, 2008Publication date: August 20, 2009Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Yong Seo CHO, You Seung KIM, Jae Kyun LEE, Hyunah CHOO, Ae Nim PAE
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Patent number: 7538127Abstract: A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is 4 to 10; R4 and R5 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R4 and R5 not more than 4; R6 and R7 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R6 and R7 is not more than 4, and Ar1 is a group selected from (a), (b), (c) and (d).Type: GrantFiled: February 12, 2004Date of Patent: May 26, 2009Assignee: Glaxo Group LimitedInventors: Keith Biggadike, Philip Charles Box, Diane Mary Coe, Duncan Stuart Holmes, Brian Edgar Looker, Panayiotis Alexandrou Procopiou
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Publication number: 20090069580Abstract: A reductive cross coupling reaction process for functionalization of a nucleophilic alkene can be achieved. The nucleophilic alkene and a nucleophilic cross coupling partner compound can be reacted in the presence of an oxidizable alcohol and a suitable catalyst to form a reductive coupling product. Various additives can also be useful to refine the process such as by mitigating certain undesirable intermediates, facilitating specific site selectivity for various substitutions or reaction sites, etc. Chiral additives can be optionally used which act to provide asymmetric catalysis, e.g. allow for regioselective and stereoselective production of reductive coupling products. A reductive cross coupling pathway can include oxidizing the oxidizable alcohol to form a catalyst hydride. The nucleophilic alkene can be inserted into the catalyst hydride to form a catalyst-alkyl intermediate.Type: ApplicationFiled: June 25, 2008Publication date: March 12, 2009Inventors: Matthew S. Sigman, Keith M. Gligorich
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Publication number: 20080260971Abstract: The present invention relates to a liquid-crystalline medium comprising 1,2-difluoroethene compounds of the general formula I, in which R1, ring A, Z1, Z2, m, X and L1-6 are as defined in claim 1. The invention also relates to the use of the medium for electro-optical purposes and to displays containing this medium. Novel 1,2-difluoroethene compounds having 3 or more rings are disclosed.Type: ApplicationFiled: May 18, 2006Publication date: October 23, 2008Inventors: Michael Wittek, Markus Czanta, Harald Hirschmann, Volker Reiffenrath
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Patent number: 7417059Abstract: The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of diseases such as, cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, and septic shock.Type: GrantFiled: March 31, 2005Date of Patent: August 26, 2008Assignee: Takeda Pharmacetical Company LimitedInventors: Norikazu Tamura, Takashi Ichikawa, Masayuki Ii
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Publication number: 20080188548Abstract: Novel cyclic ether vitamin D3 compounds having a cyclic ether side chain are disclosed. These compounds were first identified as metabolites of 3-epi vitamin D3 produced via a tissue-specific metabolic pathway which catalyzes the formation of a cyclic ether structure. Also disclosed are 1?(OH) 3-epi vitamin D3 compounds, which are produced via the epimerization of a 3-?-hydroxyl group of 1?(OH) vitamin D3 precursor in vivo. The vitamin D3 compounds of the present invention can be used as substitutes for natural and synthetic vitamin D3 compounds.Type: ApplicationFiled: December 30, 2003Publication date: August 7, 2008Inventor: Satyanarayana G. Reddy
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Publication number: 20080132716Abstract: Disclosed are compounds of formula I processes for the preparation thereof, and liquid-crystalline media and electro-optical displays containing said compounds.Type: ApplicationFiled: September 12, 2007Publication date: June 5, 2008Inventors: Lars Lietzau, Markus Czanta, Harald Hirschmann, Michael Wittek
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Publication number: 20080108826Abstract: Processes for the preparation of 4-alkoxytetrahydropyrane derivatives used in the preparation of 4-alkoxy-7-(tetrahydropyran-4-yl)-benzothiazol-2-ylamine and derivatives.Type: ApplicationFiled: October 29, 2007Publication date: May 8, 2008Inventor: Paul Spurr
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Patent number: 7361388Abstract: The invention relates to liquid-crystalline compounds of formula (I), wherein R11, X11, Z11, Z12, Z13, L11, L12, L13, L14, L15 and L16 have the meanings as cited in Claim 1, and to a method for the production thereof, their use in liquid-crystalline media, liquid-crystalline media containing at least one compound of formula (I), and to electro-optical displays containing a liquid-crystalline medium of this typeType: GrantFiled: May 24, 2004Date of Patent: April 22, 2008Assignee: Merck Patent GmbHInventors: Peer Kirsch, Eike Poetsch, Atsutaka Manabe
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Publication number: 20080027096Abstract: The invention provides compounds of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, for use in the treatment or prophylaxis of condition mediated by an androgen receptor.Type: ApplicationFiled: March 4, 2005Publication date: January 31, 2008Inventors: Neeraj Garg, Eva Kristina Kock, Henrik Per Hakan Jernstedt, Mikael Johan Gillner
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Patent number: 7314943Abstract: The invention relates to pyran derivatives of formula I and processes and intermediates for their preparation and derivatisation, and the use thereof in liquid-crystalline media.Type: GrantFiled: May 25, 2004Date of Patent: January 1, 2008Assignee: Merck Patent GmbHInventors: Eike Poetsch, Volker Meyer, Werner Binder, Michael Heckmeier, Georg Luessem, Stephan Guertler
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Patent number: 7291367Abstract: The invention relates to liquid-crystalline compounds of the formula (I) in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, a, b and c have the meanings indicated in Claim 1, and to liquid-crystalline media comprising at least one compound of the (I) and to electro-optical displays containing a liquid-crystalline medium of this type.Type: GrantFiled: November 17, 2003Date of Patent: November 6, 2007Assignee: Merck Patent GmbHInventors: Peer Kirsch, Alexander Hahn, Eike Poetsch, Volker Meyer, Michael Heckmeier, Melanie Klasen-Memmer, Georg Luessem, Christian Hock
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Patent number: 7253194Abstract: The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral ?-carbon of D-?-amino acids and their use in methods of therapy, including the treatment of inflammatory diseases, and to compositions and enantiomeric mixtures containing them.Type: GrantFiled: July 24, 2001Date of Patent: August 7, 2007Assignee: The University of QueenslandInventors: Robert C Reid, Christopher I Clark, Karl Hansford, Martin J Stoermer, Ross P McGeary, David P Fairlie, Karl Schafer
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Patent number: 7214681Abstract: Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.Type: GrantFiled: February 10, 2004Date of Patent: May 8, 2007Assignee: Prosidion LimitedInventors: Matthew Colin Thor Fyfe, Lisa Sarah Gardner, Maseo Nawano, Martin James Procter, Chrystelle Marie Rasamison, Karen Lesley Schofield, Vilasben Kanji Shah, Kosuke Yasuda
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Patent number: 7157589Abstract: The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R4, R5 and R6 are as described in the specification.Type: GrantFiled: March 1, 2004Date of Patent: January 2, 2007Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Joachim Ernst Berkner, Scott Duncan, John Mills
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Patent number: 7148363Abstract: An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or (3): In formulae (1) through (4), R1 and R2 are H or F, R3 is H, F, or an alkyl, alkenyl, fluoroalkyl or fluoroalkenyl group, R4 and R5 are H, halogen, or an alkyl, alkenyl, halogenated alkyl or halogenated alkenyl group; and X and Y are an unsubstituted or substituted hydrocarbon group, and dashed line - - - means that X and Y may be bonded together to form a cyclic structure.Type: GrantFiled: November 15, 2004Date of Patent: December 12, 2006Assignee: Tosoh CorporationInventors: Shinichi Ishikawa, Hisao Eguchi